Motif ID: ESR1.p2

Z-value: 1.511


Transcription factors associated with ESR1.p2:

Gene SymbolEntrez IDGene Name
ESR1 2099 estrogen receptor 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ESR1chr6_+_1521284530.101.3e-01Click!


Activity profile for motif ESR1.p2.

activity profile for motif ESR1.p2


Sorted Z-values histogram for motif ESR1.p2

Sorted Z-values for motif ESR1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ESR1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_-_122618098 18.228 ANXA5
annexin A5
chr5_+_150400132 17.435 GPX3
glutathione peroxidase 3 (plasma)
chr4_-_122618129 17.346 ANXA5
annexin A5
chr4_-_122618140 16.964 NM_001154
ANXA5
annexin A5
chr13_+_110959592 16.813 NM_001846
COL4A2
collagen, type IV, alpha 2
chr4_-_57976550 16.598 NM_001253835
NM_001553
IGFBP7

insulin-like growth factor binding protein 7

chr11_+_832965 14.888 CD151
CD151 molecule (Raph blood group)
chr17_-_3571905 13.636 NM_001204698
NM_014604
TAX1BP3

Tax1 (human T-cell leukemia virus type I) binding protein 3

chr5_+_150399980 12.952 NM_002084
GPX3
glutathione peroxidase 3 (plasma)
chr12_-_56122124 12.747 CD63
CD63 molecule
chr6_+_7541837 12.692 DSP
desmoplakin
chr11_+_129939792 11.672 APLP2
amyloid beta (A4) precursor-like protein 2
chr5_+_178286913 11.602 NM_058230
ZNF354B
zinc finger protein 354B
chr17_-_74707000 11.556 NM_001008528
NM_001008529
NM_198530
MXRA7


matrix-remodelling associated 7


chr7_-_47621635 11.450 TNS3
tensin 3
chr7_-_47621741 11.346 NM_022748
TNS3
tensin 3
chr17_-_3571819 11.339 TAX1BP3
Tax1 (human T-cell leukemia virus type I) binding protein 3
chr14_+_105941061 11.068 NM_001312
CRIP2
cysteine-rich protein 2
chr1_-_201476248 10.863 NM_001193570
NM_004078
CSRP1

cysteine and glycine-rich protein 1

chr1_-_201476241 10.847 CSRP1
cysteine and glycine-rich protein 1
chr6_+_7541863 10.794 NM_001008844
NM_004415
DSP

desmoplakin

chr6_+_7541892 10.782 DSP
desmoplakin
chr11_+_129939787 10.744 APLP2
amyloid beta (A4) precursor-like protein 2
chr1_-_201476218 10.650 CSRP1
cysteine and glycine-rich protein 1
chr11_+_129939807 10.527 APLP2
amyloid beta (A4) precursor-like protein 2
chr13_-_110959441 10.490 NM_001845
COL4A1
collagen, type IV, alpha 1
chr6_+_148663953 10.394 SASH1
SAM and SH3 domain containing 1
chr1_-_201475966 10.331 NM_001193571
CSRP1
cysteine and glycine-rich protein 1
chr11_-_63381940 10.315 NM_001128203
PLA2G16
phospholipase A2, group XVI
chr16_+_56659584 10.246 NM_175617
MT1E
metallothionein 1E
chr11_-_63381840 10.031 PLA2G16
phospholipase A2, group XVI
chr1_+_19923457 9.915 NM_001204088
NM_001204089
NM_001032363
NM_001204082
NM_001204083
C1orf151-NBL1

MINOS1


C1orf151-NBL1 readthrough

mitochondrial inner membrane organizing system 1


chr9_+_123963728 9.892 GSN
gelsolin
chr11_-_63381485 9.862 PLA2G16
phospholipase A2, group XVI
chr8_+_98881277 9.783 NM_002380
NM_030583
MATN2

matrilin 2

chr11_-_63381907 9.747 NM_007069
PLA2G16
phospholipase A2, group XVI
chr11_+_129939667 9.602 NM_001142276
NM_001142277
NM_001142278
NM_001642
APLP2



amyloid beta (A4) precursor-like protein 2



chr11_-_1785190 9.479 NM_001909
CTSD
cathepsin D
chr6_+_148663728 9.477 NM_015278
SASH1
SAM and SH3 domain containing 1
chr17_-_48264039 9.232 COL1A1
collagen, type I, alpha 1
chr18_+_55711890 9.099 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr11_-_33757872 8.966 NM_000611
NM_203329
NM_203330
NM_203331
CD59



CD59 molecule, complement regulatory protein



chr7_+_75931829 8.926 NM_001540
HSPB1
heat shock 27kDa protein 1
chr7_+_75931991 8.923 HSPB1
heat shock 27kDa protein 1
chr16_+_55515468 8.510 NM_001127891
MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
chr6_+_31783280 8.465 NM_005345
HSPA1A
heat shock 70kDa protein 1A
chr9_+_97488943 8.459 NM_001193331
NM_032823
C9orf3

chromosome 9 open reading frame 3

chr9_+_97488993 8.444 C9orf3
chromosome 9 open reading frame 3
chr5_-_122372413 8.384 NM_000943
PPIC
peptidylprolyl isomerase C (cyclophilin C)
chr11_+_832909 8.318 NM_001039490
NM_004357
NM_139029
NM_139030
CD151



CD151 molecule (Raph blood group)



chr8_+_38854431 7.942 NM_003816
ADAM9
ADAM metallopeptidase domain 9
chr11_+_833007 7.923 CD151
CD151 molecule (Raph blood group)
chr20_-_62130390 7.867 NM_001958
EEF1A2
eukaryotic translation elongation factor 1 alpha 2
chr4_-_17513676 7.797 NM_000320
QDPR
quinoid dihydropteridine reductase
chr22_+_33197678 7.776 TIMP3
TIMP metallopeptidase inhibitor 3
chr8_+_38854524 7.662 ADAM9
ADAM metallopeptidase domain 9
chrX_+_134166318 7.644 NM_001078171
FAM127A
family with sequence similarity 127, member A
chr2_-_85641153 7.622 CAPG
capping protein (actin filament), gelsolin-like
chr6_+_31783314 7.622 HSPA1A
HSPA1B
heat shock 70kDa protein 1A
heat shock 70kDa protein 1B
chr11_-_1785104 7.494 CTSD
cathepsin D
chr21_+_42540054 7.232 BACE2
beta-site APP-cleaving enzyme 2
chr3_-_133748828 7.192 NM_005630
SLCO2A1
solute carrier organic anion transporter family, member 2A1
chr2_-_20425166 7.186 NM_001006946
SDC1
syndecan 1
chr22_+_38142316 6.973 TRIOBP
TRIO and F-actin binding protein
chr11_+_129939847 6.896 APLP2
amyloid beta (A4) precursor-like protein 2
chr21_+_42540092 6.878 BACE2
beta-site APP-cleaving enzyme 2
chr1_-_94702916 6.824 ARHGAP29
Rho GTPase activating protein 29
chr3_+_171757413 6.730 NM_022763
FNDC3B
fibronectin type III domain containing 3B
chr22_+_33197744 6.673 TIMP3
TIMP metallopeptidase inhibitor 3
chr17_-_74707066 6.614 MXRA7
matrix-remodelling associated 7
chr21_-_45196200 6.550 NM_000100
CSTB
cystatin B (stefin B)
chr21_-_45196149 6.505 CSTB
cystatin B (stefin B)
chr9_-_138987096 6.464 NM_144653
NACC2
NACC family member 2, BEN and BTB (POZ) domain containing
chr6_+_148664124 6.415 SASH1
SAM and SH3 domain containing 1
chr3_-_133748727 6.386 SLCO2A1
solute carrier organic anion transporter family, member 2A1
chr5_+_179248089 6.385 SQSTM1
sequestosome 1
chr22_+_38142255 6.332 TRIOBP
TRIO and F-actin binding protein
chr2_-_85641128 6.323 CAPG
capping protein (actin filament), gelsolin-like
chr1_-_167522979 6.307 CREG1
cellular repressor of E1A-stimulated genes 1
chr7_+_75932865 6.260 HSPB1
heat shock 27kDa protein 1
chr1_-_68299047 6.223 NM_018841
GNG12
guanine nucleotide binding protein (G protein), gamma 12
chr20_+_48807365 6.168 CEBPB
CCAAT/enhancer binding protein (C/EBP), beta
chr5_+_179247911 6.140 SQSTM1
sequestosome 1
chr9_+_114393543 6.136 NM_001015882
NM_004125
DNAJC25
DNAJC25-GNG10
DnaJ (Hsp40) homolog, subfamily C , member 25
DNAJC25-GNG10 readthrough
chr1_-_167523016 6.111 NM_003851
CREG1
cellular repressor of E1A-stimulated genes 1
chr15_+_22892699 6.072 CYFIP1
cytoplasmic FMR1 interacting protein 1
chr6_+_30294224 5.846


chr15_+_101420004 5.801 NM_000693
ALDH1A3
aldehyde dehydrogenase 1 family, member A3
chr19_-_4400470 5.797 NM_001199943
NM_003025
SH3GL1

SH3-domain GRB2-like 1

chr15_+_41136622 5.778 NM_001032367
SPINT1
serine peptidase inhibitor, Kunitz type 1
chr1_-_94703252 5.762 NM_004815
ARHGAP29
Rho GTPase activating protein 29
chr11_-_1785087 5.659 CTSD
cathepsin D
chr11_-_1785126 5.617 CTSD
cathepsin D
chr1_-_59042827 5.604 TACSTD2
tumor-associated calcium signal transducer 2
chr1_-_27816542 5.515 WASF2
WAS protein family, member 2
chr15_+_22892683 5.466 NM_014608
CYFIP1
cytoplasmic FMR1 interacting protein 1
chr15_+_101420032 5.433 ALDH1A3
aldehyde dehydrogenase 1 family, member A3
chr15_+_41136178 5.431 NM_003710
NM_181642
SPINT1

serine peptidase inhibitor, Kunitz type 1

chr3_-_46505077 5.380 NM_001199149
LTF
lactotransferrin
chr1_+_151512760 5.373 NM_001126337
NM_020127
TUFT1

tuftelin 1

chr20_-_23618382 5.366 NM_000099
CST3
cystatin C
chr16_-_3074225 5.358 NM_001002017
NM_001002018
NM_017885
HCFC1R1


host cell factor C1 regulator 1 (XPO1 dependent)


chr14_+_65007163 5.353 NM_021979
HSPA2
heat shock 70kDa protein 2
chr5_+_179247903 5.324 SQSTM1
sequestosome 1
chr1_+_223900061 5.286 NM_001748
CAPN2
calpain 2, (m/II) large subunit
chr2_-_216300770 5.174 NM_002026
NM_054034
NM_212474
NM_212476
NM_212478
NM_212482
FN1





fibronectin 1





chr16_+_56659679 5.169 MT1E
metallothionein 1E
chr19_+_45349560 5.146 PVRL2
poliovirus receptor-related 2 (herpesvirus entry mediator B)
chr22_+_19929310 5.108 COMT
catechol-O-methyltransferase
chr22_-_19166276 5.005 SLC25A1
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
chr3_-_81810816 4.961 GBE1
glucan (1,4-alpha-), branching enzyme 1
chr2_-_110371669 4.953 NM_144710
NM_178584
SEPT10

septin 10

chr2_-_47168902 4.942 NM_001171508
NM_001171511
MCFD2

multiple coagulation factor deficiency 2

chr14_-_21493858 4.934 NDRG2
NDRG family member 2
chr14_-_21493910 4.930 NM_016250
NM_201535
NM_201536
NM_201537
NDRG2



NDRG family member 2



chr15_+_22892723 4.883 CYFIP1
cytoplasmic FMR1 interacting protein 1
chr12_-_123756164 4.802 NM_004642
CDK2AP1
cyclin-dependent kinase 2 associated protein 1
chr2_+_182756468 4.799 NM_001130445
NM_006751
SSFA2

sperm specific antigen 2

chr7_+_143079354 4.795 ZYX
zyxin
chr22_-_19166133 4.763 SLC25A1
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
chr1_+_223900212 4.746 CAPN2
calpain 2, (m/II) large subunit
chr14_-_69445772 4.700 ACTN1
actinin, alpha 1
chr14_+_65007418 4.660 HSPA2
heat shock 70kDa protein 2
chr17_+_57785011 4.656 VMP1
vacuole membrane protein 1
chr17_-_1303402 4.643 YWHAE
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
chr19_-_4400357 4.641 NM_001199944
SH3GL1
SH3-domain GRB2-like 1
chr12_+_66218879 4.627 HMGA2
high mobility group AT-hook 2
chr8_+_82192717 4.626 NM_001444
FABP5
fatty acid binding protein 5 (psoriasis-associated)
chr12_+_19282402 4.602 NM_001143821
NM_001190860
NM_019012
PLEKHA5


pleckstrin homology domain containing, family A member 5


chr15_-_72523713 4.597 NM_001206796
NM_001206797
NM_001206798
NM_002654
NM_182470
NM_182471
PKM2





pyruvate kinase, muscle





chr11_+_842821 4.584 NM_001025238
NM_001025239
NM_003271
NM_001025235
NM_001025236
TSPAN4




tetraspanin 4




chr15_-_79237320 4.564 CTSH
cathepsin H
chr2_-_1748317 4.548 PXDN
peroxidasin homolog (Drosophila)
chr11_-_82611358 4.536 NM_005040
NM_199418
PRCP

prolylcarboxypeptidase (angiotensinase C)

chr11_-_62314291 4.484 NM_001620
NM_024060
AHNAK

AHNAK nucleoprotein

chr10_-_97050671 4.480 NM_020992
PDLIM1
PDZ and LIM domain 1
chr18_+_29078026 4.438 NM_001943
DSG2
desmoglein 2
chr19_+_15218141 4.434 NM_033025
SYDE1
synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
chr6_+_17393610 4.430 NM_006366
CAP2
CAP, adenylate cyclase-associated protein, 2 (yeast)
chr1_+_223900226 4.430 CAPN2
calpain 2, (m/II) large subunit
chr22_-_19166296 4.402 NM_005984
SLC25A1
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
chr2_+_119981389 4.394 STEAP3
STEAP family member 3, metalloreductase
chr16_+_66400524 4.365 NM_001795
CDH5
cadherin 5, type 2 (vascular endothelium)
chr6_-_47277354 4.344 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr10_-_79686279 4.343 NM_004747
DLG5
discs, large homolog 5 (Drosophila)
chr9_+_112810877 4.329 NM_001004065
NM_001198656
AKAP2

A kinase (PRKA) anchor protein 2

chr9_+_137533643 4.288 NM_000093
COL5A1
collagen, type V, alpha 1
chr5_-_10761341 4.286 DAP
death-associated protein
chr1_-_150241210 4.279 APH1A
anterior pharynx defective 1 homolog A (C. elegans)
chr17_+_35849997 4.270 DUSP14
dual specificity phosphatase 14
chr17_+_35849950 4.252 NM_007026
DUSP14
dual specificity phosphatase 14
chrX_+_135229536 4.242 NM_001159702
NM_001159703
NM_001449
FHL1


four and a half LIM domains 1


chr5_+_131593388 4.226 PDLIM4
PDZ and LIM domain 4
chr9_-_99382073 4.219 NM_003671
NM_033331
CDC14B

CDC14 cell division cycle 14 homolog B (S. cerevisiae)

chr18_-_21977785 4.211 NM_080597
OSBPL1A
oxysterol binding protein-like 1A
chr7_+_44143945 4.196 NM_001129
AEBP1
AE binding protein 1
chr12_-_50677238 4.183 NM_001113546
NM_016357
LIMA1

LIM domain and actin binding 1

chr14_-_103988829 4.157 CKB
creatine kinase, brain
chr19_+_676346 4.156 NM_005860
FSTL3
follistatin-like 3 (secreted glycoprotein)
chr11_+_394238 4.155 PKP3
plakophilin 3
chr2_+_85360373 4.109 NM_031283
TCF7L1
transcription factor 7-like 1 (T-cell specific, HMG-box)
chr9_+_706744 4.099 NM_153186
KANK1
KN motif and ankyrin repeat domains 1
chr14_-_93214873 4.095 NM_001008530
NM_005606
LGMN

legumain

chr20_+_55204307 4.080 NM_003222
TFAP2C
transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
chr15_-_79237353 4.079 NM_004390
CTSH
cathepsin H
chr6_+_29894105 4.064


chr11_+_120206903 4.056 ARHGEF12
Rho guanine nucleotide exchange factor (GEF) 12
chr9_+_19049424 4.004 RRAGA
Ras-related GTP binding A
chr16_+_66968319 3.991 NM_003869
NM_198061
CES2

carboxylesterase 2

chr21_-_43373938 3.976 NM_015500
C2CD2
C2 calcium-dependent domain containing 2
chr6_-_47277246 3.963 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr22_+_38302296 3.935 MICALL1
MICAL-like 1
chr20_-_23030141 3.897 NM_000361
THBD
thrombomodulin
chr17_-_1303548 3.886 NM_006761
YWHAE
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
chr5_-_151138139 3.877 NM_004045
ATOX1
ATX1 antioxidant protein 1 homolog (yeast)
chr7_+_44144002 3.851 AEBP1
AE binding protein 1
chr1_-_95392501 3.845 NM_001839
CNN3
calponin 3, acidic
chr16_+_66968360 3.834 CES2
carboxylesterase 2
chr9_+_133589267 3.833 NM_007313
ABL1
c-abl oncogene 1, non-receptor tyrosine kinase
chr22_-_19165872 3.826 SLC25A1
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
chr15_+_90808833 3.792 NM_001033088
NGRN
neugrin, neurite outgrowth associated
chr21_+_34775740 3.771 IFNGR2
interferon gamma receptor 2 (interferon gamma transducer 1)
chr5_-_10761344 3.757 NM_004394
DAP
death-associated protein
chr16_+_66968390 3.739 CES2
carboxylesterase 2
chr2_-_175869910 3.704 NM_001822
NM_001025201
CHN1

chimerin (chimaerin) 1

chr1_-_23857711 3.678 NM_004091
E2F2
E2F transcription factor 2
chr5_-_10761179 3.669 DAP
death-associated protein
chr12_-_56709831 3.668 NM_001190991
NM_014255
CNPY2

canopy 2 homolog (zebrafish)

chr11_+_64001974 3.663 NM_001243733
NM_003377
VEGFB

vascular endothelial growth factor B

chr19_+_40872709 3.661 PLD3
phospholipase D family, member 3
chr1_-_21978287 3.645 NM_001145658
RAP1GAP
RAP1 GTPase activating protein
chr19_-_17356022 3.603 NM_005234
NR2F6
nuclear receptor subfamily 2, group F, member 6
chr3_+_52529370 3.581 STAB1
stabilin 1
chr9_-_89562103 3.574 NM_002048
GAS1
growth arrest-specific 1
chr10_-_126849556 3.556 NM_001083914
CTBP2
C-terminal binding protein 2
chr19_+_35607218 3.533 FXYD3
FXYD domain containing ion transport regulator 3
chr10_+_75670861 3.532 NM_001145031
NM_002658
PLAU

plasminogen activator, urokinase

chr20_+_62372436 3.530 SLC2A4RG
SLC2A4 regulator
chr16_+_15068832 3.530 NM_015027
PDXDC1
pyridoxal-dependent decarboxylase domain containing 1
chr2_-_224903933 3.527 NM_001136528
NM_006216
SERPINE2

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.17 6.61e-13 GO:0009987 cellular process
1.22 5.00e-08 GO:0065007 biological regulation
1.23 2.49e-07 GO:0050794 regulation of cellular process
1.50 3.19e-07 GO:0042221 response to chemical stimulus
1.36 6.13e-07 GO:0023052 signaling
1.50 8.74e-07 GO:0065008 regulation of biological quality
1.37 3.46e-06 GO:0007165 signal transduction
1.21 4.73e-06 GO:0050789 regulation of biological process
1.32 5.11e-06 GO:0051716 cellular response to stimulus
1.59 1.55e-05 GO:0009966 regulation of signal transduction
1.36 2.49e-05 GO:0048856 anatomical structure development
1.59 3.13e-05 GO:0035556 intracellular signal transduction
1.22 4.94e-05 GO:0050896 response to stimulus
1.52 9.09e-05 GO:0023051 regulation of signaling
1.31 1.15e-04 GO:0032502 developmental process
1.19 1.50e-04 GO:0008152 metabolic process
1.40 2.61e-04 GO:0048519 negative regulation of biological process
1.36 2.97e-04 GO:0048731 system development
1.38 4.25e-04 GO:0048522 positive regulation of cellular process
1.65 4.81e-04 GO:0032879 regulation of localization
2.26 5.71e-04 GO:0030029 actin filament-based process
1.50 7.48e-04 GO:0009653 anatomical structure morphogenesis
1.61 8.28e-04 GO:0010646 regulation of cell communication
1.40 1.02e-03 GO:0048523 negative regulation of cellular process
2.23 1.20e-03 GO:0001944 vasculature development
1.54 1.40e-03 GO:0010033 response to organic substance
1.92 1.79e-03 GO:0072358 cardiovascular system development
1.92 1.79e-03 GO:0072359 circulatory system development
1.43 2.18e-03 GO:0044281 small molecule metabolic process
2.24 2.72e-03 GO:0001568 blood vessel development
1.33 3.32e-03 GO:0048518 positive regulation of biological process
2.24 3.32e-03 GO:0030334 regulation of cell migration
2.17 3.38e-03 GO:0051270 regulation of cellular component movement
1.29 3.38e-03 GO:0007275 multicellular organismal development
2.22 4.58e-03 GO:2000145 regulation of cell motility
1.40 5.31e-03 GO:0048583 regulation of response to stimulus
1.59 7.61e-03 GO:0070887 cellular response to chemical stimulus
2.21 8.48e-03 GO:0030036 actin cytoskeleton organization
1.27 1.20e-02 GO:0016043 cellular component organization
1.45 1.26e-02 GO:0007399 nervous system development
1.81 1.26e-02 GO:0044283 small molecule biosynthetic process
1.18 1.38e-02 GO:0044237 cellular metabolic process
1.61 1.54e-02 GO:0051128 regulation of cellular component organization
1.95 1.58e-02 GO:0090066 regulation of anatomical structure size
2.08 1.82e-02 GO:0040012 regulation of locomotion
1.58 1.84e-02 GO:0051704 multi-organism process
2.00 1.91e-02 GO:0032535 regulation of cellular component size
1.57 1.95e-02 GO:0050793 regulation of developmental process
1.55 2.08e-02 GO:0042127 regulation of cell proliferation
1.17 2.54e-02 GO:0044238 primary metabolic process
1.67 3.74e-02 GO:0007167 enzyme linked receptor protein signaling pathway
1.70 3.79e-02 GO:0042060 wound healing
1.25 4.43e-02 GO:0071840 cellular component organization or biogenesis

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.29 4.78e-20 GO:0005737 cytoplasm
1.33 3.31e-14 GO:0044444 cytoplasmic part
1.15 3.90e-12 GO:0005622 intracellular
1.16 4.35e-12 GO:0044424 intracellular part
2.28 2.74e-05 GO:0015629 actin cytoskeleton
1.70 7.13e-05 GO:0005624 membrane fraction
1.68 9.15e-05 GO:0005626 insoluble fraction
1.06 1.71e-04 GO:0044464 cell part
1.57 1.72e-04 GO:0000267 cell fraction
1.06 1.76e-04 GO:0005623 cell
1.12 2.34e-04 GO:0043229 intracellular organelle
1.12 2.45e-04 GO:0043226 organelle
1.45 4.54e-04 GO:0005856 cytoskeleton
2.55 5.02e-04 GO:0070161 anchoring junction
1.36 1.63e-03 GO:0005829 cytosol
1.72 1.68e-03 GO:0030054 cell junction
1.35 2.00e-03 GO:0044459 plasma membrane part
1.18 4.17e-03 GO:0044446 intracellular organelle part
2.46 4.81e-03 GO:0005912 adherens junction
1.18 5.19e-03 GO:0044422 organelle part
1.91 5.21e-03 GO:0048471 perinuclear region of cytoplasm
2.22 7.36e-03 GO:0005911 cell-cell junction
1.48 7.79e-03 GO:0005783 endoplasmic reticulum
1.50 1.05e-02 GO:0005794 Golgi apparatus
1.12 1.08e-02 GO:0043231 intracellular membrane-bounded organelle
1.12 1.28e-02 GO:0043227 membrane-bounded organelle
2.75 3.09e-02 GO:0042470 melanosome
2.75 3.09e-02 GO:0048770 pigment granule
1.39 3.68e-02 GO:0005739 mitochondrion
4.11 3.70e-02 GO:0042641 actomyosin
2.61 4.16e-02 GO:0005925 focal adhesion
1.19 4.42e-02 GO:0071944 cell periphery

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.35 4.76e-23 GO:0005515 protein binding
1.14 1.16e-11 GO:0005488 binding
1.90 7.09e-05 GO:0008092 cytoskeletal protein binding
1.75 8.30e-05 GO:0019899 enzyme binding
3.35 8.17e-04 GO:0019199 transmembrane receptor protein kinase activity
1.99 4.12e-03 GO:0003779 actin binding
1.62 4.73e-03 GO:0042802 identical protein binding
3.06 1.11e-02 GO:0005201 extracellular matrix structural constituent
2.67 2.10e-02 GO:0019838 growth factor binding
1.60 3.00e-02 GO:0046983 protein dimerization activity