Motif ID: ESRRA.p2

Z-value: 2.666


Transcription factors associated with ESRRA.p2:

Gene SymbolEntrez IDGene Name
ESRRA 2101 estrogen-related receptor alpha

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ESRRAchr11_+_640730400.274.3e-05Click!


Activity profile for motif ESRRA.p2.

activity profile for motif ESRRA.p2


Sorted Z-values histogram for motif ESRRA.p2

Sorted Z-values for motif ESRRA.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ESRRA.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_+_145149985 82.272 CYC1
cytochrome c-1
chr2_-_176046120 81.835 NM_001002258
NM_001190329
NM_001689
ATP5G3


ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)


chr10_+_81107259 80.838 PPIF
peptidylprolyl isomerase F
chr10_+_81107242 80.779 PPIF
peptidylprolyl isomerase F
chr5_+_218428 50.854 SDHA
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
chrX_+_118602391 47.372 SLC25A5
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
chr5_+_218441 45.038 SDHA
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
chr8_+_145149936 42.879 NM_001916
CYC1
cytochrome c-1
chr3_-_131221649 42.847 NM_007208
MRPL3
mitochondrial ribosomal protein L3
chr8_+_145149978 41.774 CYC1
cytochrome c-1
chr10_+_81107219 40.200 NM_005729
PPIF
peptidylprolyl isomerase F
chr10_+_81107228 40.019 PPIF
peptidylprolyl isomerase F
chr12_-_21810720 37.995 NM_001174097
LDHB
lactate dehydrogenase B
chr2_-_44223131 37.915 NM_133259
LRPPRC
leucine-rich PPR-motif containing
chr12_-_21810779 37.865 NM_002300
LDHB
lactate dehydrogenase B
chr12_-_21810733 37.493 LDHB
lactate dehydrogenase B
chr12_-_21810754 37.309 LDHB
lactate dehydrogenase B
chr19_-_13044459 36.909 FARSA
phenylalanyl-tRNA synthetase, alpha subunit
chr16_+_21964700 36.800 UQCRC2
ubiquinol-cytochrome c reductase core protein II
chr20_+_3776905 36.716 CDC25B
cell division cycle 25 homolog B (S. pombe)
chr12_-_21810769 36.692 LDHB
lactate dehydrogenase B
chr16_+_21964677 36.637 UQCRC2
ubiquinol-cytochrome c reductase core protein II
chr20_+_3776385 36.278 NM_004358
NM_021872
NM_021873
CDC25B


cell division cycle 25 homolog B (S. pombe)


chr10_-_120938276 35.594 PRDX3
peroxiredoxin 3
chr16_+_21964608 35.355 NM_003366
UQCRC2
ubiquinol-cytochrome c reductase core protein II
chr7_-_30029904 35.022 NM_001145514
SCRN1
secernin 1
chr12_+_6976694 35.021 TPI1
triosephosphate isomerase 1
chr18_-_43678233 34.996 ATP5A1
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
chr12_+_6976583 33.863 NM_001159287
NM_000365
TPI1

triosephosphate isomerase 1

chr1_+_46769336 33.770 NM_006004
UQCRH
ubiquinol-cytochrome c reductase hinge protein
chr2_-_44223112 32.950 LRPPRC
leucine-rich PPR-motif containing
chr15_+_40453263 32.041 BUB1B
budding uninhibited by benzimidazoles 1 homolog beta (yeast)
chr14_-_104387837 32.023 C14orf2
chromosome 14 open reading frame 2
chr10_+_99185977 31.991 PGAM1
phosphoglycerate mutase 1 (brain)
chr5_+_218355 31.846 NM_004168
SDHA
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
chr8_+_110346549 31.746 NM_001193557
NM_020189
ENY2

enhancer of yellow 2 homolog (Drosophila)

chr11_+_65769886 30.606 BANF1
barrier to autointegration factor 1
chr8_-_131028674 30.477 FAM49B
family with sequence similarity 49, member B
chr10_-_120938337 30.397 NM_006793
NM_014098
PRDX3

peroxiredoxin 3

chr11_+_65769956 30.276 BANF1
barrier to autointegration factor 1
chr5_+_218447 30.134 SDHA
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
chr9_-_130889993 29.914 PTGES2
prostaglandin E synthase 2
chrX_-_134156488 29.859 NM_001078173
FAM127C
family with sequence similarity 127, member C
chr2_+_198365012 29.809 HSPE1
heat shock 10kDa protein 1 (chaperonin 10)
chr16_-_81040439 29.718 NM_020188
C16orf61
chromosome 16 open reading frame 61
chr3_+_179322572 29.661 NM_001199957
NM_001199958
NM_002492
NDUFB5


NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa


chr12_+_120875891 29.309 NM_004373
COX6A1
cytochrome c oxidase subunit VIa polypeptide 1
chr3_-_42845911 29.290 NM_001099668
HIGD1A
HIG1 hypoxia inducible domain family, member 1A
chr2_-_44223039 29.226 LRPPRC
leucine-rich PPR-motif containing
chr7_-_30029284 29.106 NM_001145515
NM_014766
NM_001145513
SCRN1


secernin 1


chr22_+_20105145 28.847 RANBP1
RAN binding protein 1
chr8_-_100905910 28.618 COX6C
cytochrome c oxidase subunit VIc
chr11_-_57298180 28.593 NM_012456
TIMM10
translocase of inner mitochondrial membrane 10 homolog (yeast)
chr4_-_74088773 28.442 ANKRD17
ankyrin repeat domain 17
chr12_-_54070108 28.403 NM_005176
ATP5G2
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
chr5_-_140027167 27.829 NDUFA2
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa
chr3_-_48647085 27.795 NM_003365
UQCRC1
ubiquinol-cytochrome c reductase core protein I
chr1_-_17380486 27.456 NM_003000
SDHB
succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
chr3_-_42845946 27.231 NM_001099669
NM_014056
HIGD1A

HIG1 hypoxia inducible domain family, member 1A

chr1_-_205719340 27.108 NM_022731
NUCKS1
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr18_-_43678195 26.987 ATP5A1
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
chr19_-_39826676 26.946 NM_004877
GMFG
glia maturation factor, gamma
chr3_-_48647052 26.869 UQCRC1
ubiquinol-cytochrome c reductase core protein I
chr16_+_4674829 26.796 MGRN1
mahogunin, ring finger 1
chr16_+_4674819 26.749 NM_001142289
NM_001142290
NM_001142291
NM_015246
MGRN1



mahogunin, ring finger 1



chr1_+_161172174 26.725 NDUFS2
NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)
chr1_+_161172163 26.704 NDUFS2
NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)
chr2_+_198365113 26.638 HSPE1
heat shock 10kDa protein 1 (chaperonin 10)
chr10_+_99186012 26.408 PGAM1
phosphoglycerate mutase 1 (brain)
chr15_+_78441733 26.235 IDH3A
isocitrate dehydrogenase 3 (NAD+) alpha
chr10_-_75012241 26.186 NM_016065
MRPS16
mitochondrial ribosomal protein S16
chr18_-_43678230 25.722 ATP5A1
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
chr19_-_2328566 25.716 NM_016199
LSM7
LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr1_+_47799447 25.648 NM_001136140
NM_016308
CMPK1

cytidine monophosphate (UMP-CMP) kinase 1, cytosolic

chr11_+_34938112 25.506 PDHX
pyruvate dehydrogenase complex, component X
chr9_+_130965666 25.254 DNM1
dynamin 1
chr18_-_43678251 24.860 ATP5A1
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
chr1_-_246580710 24.827 NM_022743
SMYD3
SET and MYND domain containing 3
chr16_-_85832900 24.775 NM_001142288
NM_006067
COX4NB

COX4 neighbor

chr6_+_34206567 24.754 NM_145905
HMGA1
high mobility group AT-hook 1
chr20_-_2641476 24.565 IDH3B
isocitrate dehydrogenase 3 (NAD+) beta
chr1_+_236558715 24.300 NM_080738
EDARADD
EDAR-associated death domain
chr2_+_109237679 24.300 NM_001193484
LIMS1
LIM and senescent cell antigen-like domains 1
chr8_-_131028833 24.299 FAM49B
family with sequence similarity 49, member B
chr8_-_100905865 24.265 COX6C
cytochrome c oxidase subunit VIc
chr12_-_102512277 24.113 NM_024057
NUP37
nucleoporin 37kDa
chr22_+_20105095 24.032 RANBP1
RAN binding protein 1
chr2_-_198364522 24.021 HSPD1
heat shock 60kDa protein 1 (chaperonin)
chr19_-_3062911 24.000 NM_198969
AES
amino-terminal enhancer of split
chr5_-_137911039 23.987 HSPA9
heat shock 70kDa protein 9 (mortalin)
chr12_-_57039785 23.982 NM_001686
ATP5B
ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
chr22_+_20105076 23.815 RANBP1
RAN binding protein 1
chrX_+_47053192 23.739 NM_003334
UBA1
ubiquitin-like modifier activating enzyme 1
chr12_+_98987674 23.642 SLC25A3
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3
chrX_-_129299680 23.488 AIFM1
apoptosis-inducing factor, mitochondrion-associated, 1
chr7_+_44836273 23.357 PPIA
peptidylprolyl isomerase A (cyclophilin A)
chr22_-_24316602 23.245 NM_001084392
DDT
D-dopachrome tautomerase
chr22_+_24309025 23.219 NM_001084393
DDTL
D-dopachrome tautomerase-like
chr4_-_7069755 23.188 NM_025196
GRPEL1
GrpE-like 1, mitochondrial (E. coli)
chr10_+_99186040 23.184 PGAM1
phosphoglycerate mutase 1 (brain)
chr10_+_99186042 23.049 PGAM1
phosphoglycerate mutase 1 (brain)
chr20_-_62130390 22.940 NM_001958
EEF1A2
eukaryotic translation elongation factor 1 alpha 2
chr5_-_137911005 22.750 HSPA9
heat shock 70kDa protein 9 (mortalin)
chr19_+_1383898 22.605 NDUFS7
NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase)
chrX_+_47053227 22.487 UBA1
ubiquitin-like modifier activating enzyme 1
chr2_-_198364560 22.275 HSPD1
heat shock 60kDa protein 1 (chaperonin)
chr6_-_2840683 22.056 SERPINB1
serpin peptidase inhibitor, clade B (ovalbumin), member 1
chr16_-_2723374 22.053 ERVK13-1
endogenous retrovirus group K13, member 1
chrX_+_47053213 22.019 UBA1
ubiquitin-like modifier activating enzyme 1
chr12_-_54069856 21.951 ATP5G2
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
chr19_+_1383904 21.899 NDUFS7
NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase)
chrX_-_129299629 21.831 AIFM1
apoptosis-inducing factor, mitochondrion-associated, 1
chr1_+_47799488 21.791 CMPK1
cytidine monophosphate (UMP-CMP) kinase 1, cytosolic
chr15_-_41694619 21.619 NM_016013
NDUFAF1
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 1
chrX_+_47053271 21.452 UBA1
ubiquitin-like modifier activating enzyme 1
chr2_-_198364623 21.390 NM_002156
HSPD1
heat shock 60kDa protein 1 (chaperonin)
chr9_+_17578952 21.147 NM_003026
SH3GL2
SH3-domain GRB2-like 2
chr1_+_201924618 20.904 NM_006335
TIMM17A
translocase of inner mitochondrial membrane 17 homolog A (yeast)
chr1_-_33502470 20.855 AK2
adenylate kinase 2
chr12_-_57039736 20.575 ATP5B
ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
chr3_+_195384941 20.534 SDHAP2
succinate dehydrogenase complex, subunit A, flavoprotein pseudogene 2
chrX_-_129299803 20.486 NM_001130847
NM_004208
NM_145812
NM_145813
AIFM1



apoptosis-inducing factor, mitochondrion-associated, 1



chr1_-_33502452 20.453 AK2
adenylate kinase 2
chr10_+_99186017 20.399 NM_002629
PGAM1
phosphoglycerate mutase 1 (brain)
chrX_+_47053302 20.369 UBA1
ubiquitin-like modifier activating enzyme 1
chr7_+_56032065 20.327 NM_001202469
NM_001483
GBAS

glioblastoma amplified sequence

chr19_+_1383877 20.322 NM_024407
NDUFS7
NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase)
chrX_+_47053234 20.277 UBA1
ubiquitin-like modifier activating enzyme 1
chr19_-_13044528 20.260 NM_004461
FARSA
phenylalanyl-tRNA synthetase, alpha subunit
chr16_-_47177902 20.209 NM_001201477
NM_018092
NETO2

neuropilin (NRP) and tolloid (TLL)-like 2

chr15_+_66694216 20.114 MAP2K1
mitogen-activated protein kinase kinase 1
chr16_+_81040515 20.018 CENPN
centromere protein N
chr9_-_130889965 20.001 PTGES2
prostaglandin E synthase 2
chr11_+_67798077 19.935 NM_002496
NDUFS8
NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase)
chrX_+_153657119 19.656 ATP6AP1
ATPase, H+ transporting, lysosomal accessory protein 1
chr19_-_3062191 19.424 NM_001130
NM_198970
AES

amino-terminal enhancer of split

chr16_-_47177832 19.388 NETO2
neuropilin (NRP) and tolloid (TLL)-like 2
chr1_+_155179005 19.373 MTX1
metaxin 1
chr22_-_43036606 19.279 NM_001165877
ATP5L2
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit G2
chr1_-_33502464 19.187 AK2
adenylate kinase 2
chr17_+_30469567 19.031 RHOT1
ras homolog gene family, member T1
chr3_-_113465101 18.927 NM_025146
NAA50
N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr8_+_86376130 18.788 NM_000067
CA2
carbonic anhydrase II
chr17_+_30469541 18.750 RHOT1
ras homolog gene family, member T1
chr3_+_184038050 18.709 NM_004953
EIF4G1
eukaryotic translation initiation factor 4 gamma, 1
chr8_-_131028646 18.520 FAM49B
family with sequence similarity 49, member B
chr1_-_67896098 18.476 NM_001018067
NM_001018068
NM_001018069
NM_015640
SERBP1



SERPINE1 mRNA binding protein 1



chr10_+_99186004 18.318 PGAM1
phosphoglycerate mutase 1 (brain)
chr1_+_161172125 18.302 NDUFS2
NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)
chr15_+_43885251 18.167 NM_020990
CKMT1B
CKMT1A
creatine kinase, mitochondrial 1B
creatine kinase, mitochondrial 1A
chr16_-_28222700 17.961 XPO6
exportin 6
chr1_-_33502428 17.960 AK2
adenylate kinase 2
chr13_-_24007822 17.906 NM_014363
SACS
spastic ataxia of Charlevoix-Saguenay (sacsin)
chr11_+_73498913 17.802 NM_016055
MRPL48
mitochondrial ribosomal protein L48
chr22_-_47134130 17.769 NM_022766
CERK
ceramide kinase
chr22_-_36681757 17.744 MYH9
myosin, heavy chain 9, non-muscle
chr10_+_62538088 17.712 NM_001170406
NM_001170407
NM_001786
NM_033379
CDK1



cyclin-dependent kinase 1



chr20_+_57466248 17.661 NM_000516
NM_001077488
NM_001077489
NM_080426
GNAS



GNAS complex locus



chr20_-_31989303 17.631 CDK5RAP1
CDK5 regulatory subunit associated protein 1
chr6_-_97345760 17.503 NM_014165
NDUFAF4
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 4
chr7_+_99686609 17.431 COPS6
COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis)
chr14_+_57735605 17.320 NM_018229
MUDENG
MU-2/AP1M2 domain containing, death-inducing
chr17_+_79670495 17.207 MRPL12
mitochondrial ribosomal protein L12
chr19_-_39826625 17.115 GMFG
glia maturation factor, gamma
chr3_-_10028512 16.972 NM_018447
TMEM111
transmembrane protein 111
chr1_+_228270802 16.946 NM_001024227
NM_001024228
ARF1

ADP-ribosylation factor 1

chr15_+_78441678 16.895 NM_005530
IDH3A
isocitrate dehydrogenase 3 (NAD+) alpha
chr22_-_50524357 16.831 NM_015166
MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr1_+_32757711 16.735 HDAC1
histone deacetylase 1
chr3_-_195808934 16.598 TFRC
transferrin receptor (p90, CD71)
chr10_-_126107493 16.539 NM_000274
NM_001171814
OAT

ornithine aminotransferase

chr3_-_195808958 16.534 NM_003234
TFRC
transferrin receptor (p90, CD71)
chr15_-_83735892 16.527 BTBD1
BTB (POZ) domain containing 1
chr17_+_79670396 16.359 NM_002949
MRPL12
mitochondrial ribosomal protein L12
chr1_+_32757702 16.162 HDAC1
histone deacetylase 1
chr14_-_105261850 16.152 AKT1
v-akt murine thymoma viral oncogene homolog 1
chr9_-_130890026 16.096 PTGES2
prostaglandin E synthase 2
chr2_+_26467615 15.991 NM_000183
HADHB
hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit
chr18_-_43678273 15.968 NM_004046
ATP5A1
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
chr17_+_46970128 15.963 NM_001002027
NM_005175
ATP5G1

ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)

chr19_+_54606141 15.896 NM_004542
NDUFA3
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa
chr9_-_130890007 15.838 PTGES2
prostaglandin E synthase 2
chrY_-_1460901 15.767 NM_001636
SLC25A6
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
chr5_+_85913762 15.563 NM_001867
COX7C
cytochrome c oxidase subunit VIIc
chr10_-_118765087 15.495 NM_001127211
NM_018330
KIAA1598

KIAA1598

chr14_+_100150596 15.486 NM_006668
CYP46A1
cytochrome P450, family 46, subfamily A, polypeptide 1
chrX_-_109683457 15.474 NM_001171689
AMMECR1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr6_-_97345747 15.350 NDUFAF4
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 4
chr20_-_31989330 15.283 NM_016082
NM_016408
CDK5RAP1

CDK5 regulatory subunit associated protein 1

chr1_+_32757707 15.247 NM_004964
HDAC1
histone deacetylase 1
chr1_+_165600433 15.183 MGST3
microsomal glutathione S-transferase 3
chr3_-_10028344 15.137 TMEM111
transmembrane protein 111
chr9_+_130965668 15.069 DNM1
dynamin 1
chr1_-_27732069 15.006 WASF2
WAS protein family, member 2
chr22_+_44351260 14.991 NM_015380
SAMM50
sorting and assembly machinery component 50 homolog (S. cerevisiae)
chr1_+_6094342 14.942 NM_001199860
KCNAB2
potassium voltage-gated channel, shaker-related subfamily, beta member 2
chr22_-_42486740 14.850 NDUFA6
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6, 14kDa
chr1_-_67896081 14.691 SERBP1
SERPINE1 mRNA binding protein 1
chr19_+_8509802 14.676 NM_005968
NM_031203
HNRNPM

heterogeneous nuclear ribonucleoprotein M

chr11_+_67033889 14.636 NM_001619
ADRBK1
adrenergic, beta, receptor kinase 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
8.89 4.14e-24 GO:0045333 cellular respiration
10.31 2.19e-23 GO:0022904 respiratory electron transport chain
7.41 6.83e-18 GO:0022900 electron transport chain
4.98 8.16e-17 GO:0015980 energy derivation by oxidation of organic compounds
4.10 6.19e-16 GO:0006091 generation of precursor metabolites and energy
1.26 6.04e-15 GO:0009987 cellular process
1.48 4.63e-14 GO:0044237 cellular metabolic process
10.51 5.56e-12 GO:0006119 oxidative phosphorylation
11.09 9.70e-12 GO:0042773 ATP synthesis coupled electron transport
11.09 9.70e-12 GO:0042775 mitochondrial ATP synthesis coupled electron transport
2.55 5.81e-11 GO:0055114 oxidation-reduction process
1.38 6.64e-11 GO:0008152 metabolic process
1.74 7.10e-11 GO:0006810 transport
1.72 2.74e-10 GO:0051234 establishment of localization
1.62 1.41e-09 GO:0051179 localization
7.04 6.10e-09 GO:0006839 mitochondrial transport
10.54 2.42e-08 GO:0006120 mitochondrial electron transport, NADH to ubiquinone
10.68 1.08e-07 GO:0009060 aerobic respiration
2.32 1.44e-06 GO:0046907 intracellular transport
9.86 1.79e-06 GO:0070585 protein localization in mitochondrion
2.06 2.79e-06 GO:0051649 establishment of localization in cell
1.97 3.49e-06 GO:0051641 cellular localization
13.55 7.67e-06 GO:0015985 energy coupled proton transport, down electrochemical gradient
13.55 7.67e-06 GO:0015986 ATP synthesis coupled proton transport
9.62 1.22e-05 GO:0006626 protein targeting to mitochondrion
9.32 1.80e-05 GO:0072655 establishment of protein localization in mitochondrion
1.85 2.56e-05 GO:0009056 catabolic process
4.31 2.83e-05 GO:0007005 mitochondrion organization
3.71 1.08e-04 GO:0006732 coenzyme metabolic process
10.17 1.69e-04 GO:0006099 tricarboxylic acid cycle
1.69 2.01e-04 GO:0044281 small molecule metabolic process
9.76 2.55e-04 GO:0046356 acetyl-CoA catabolic process
1.87 3.68e-04 GO:0044248 cellular catabolic process
1.29 4.03e-04 GO:0044238 primary metabolic process
2.30 6.97e-04 GO:0055086 nucleobase, nucleoside and nucleotide metabolic process
2.35 9.48e-04 GO:0006753 nucleoside phosphate metabolic process
2.35 9.48e-04 GO:0009117 nucleotide metabolic process
8.41 1.10e-03 GO:0009109 coenzyme catabolic process
3.84 1.74e-03 GO:0046034 ATP metabolic process
5.61 1.93e-03 GO:0015992 proton transport
11.16 2.23e-03 GO:0072384 organelle transport along microtubule
3.01 2.82e-03 GO:0051186 cofactor metabolic process
5.42 2.82e-03 GO:0006818 hydrogen transport
27.11 3.20e-03 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c
2.08 4.55e-03 GO:0046483 heterocycle metabolic process
7.18 4.86e-03 GO:0006084 acetyl-CoA metabolic process
2.26 5.09e-03 GO:0044283 small molecule biosynthetic process
12.51 5.95e-03 GO:0042776 mitochondrial ATP synthesis coupled proton transport
6.97 6.33e-03 GO:0051187 cofactor catabolic process
2.55 7.20e-03 GO:0009259 ribonucleotide metabolic process
3.95 9.79e-03 GO:0009260 ribonucleotide biosynthetic process
2.56 1.03e-02 GO:0009150 purine ribonucleotide metabolic process
5.65 1.42e-02 GO:0006733 oxidoreduction coenzyme metabolic process
4.04 1.53e-02 GO:0009152 purine ribonucleotide biosynthetic process
2.28 1.77e-02 GO:0072521 purine-containing compound metabolic process
2.57 1.96e-02 GO:0009205 purine ribonucleoside triphosphate metabolic process
2.13 2.02e-02 GO:0044282 small molecule catabolic process
2.56 2.09e-02 GO:0009199 ribonucleoside triphosphate metabolic process
2.55 2.37e-02 GO:0009144 purine nucleoside triphosphate metabolic process
1.87 2.44e-02 GO:0055085 transmembrane transport
4.40 2.76e-02 GO:0009206 purine ribonucleoside triphosphate biosynthetic process
1.46 3.03e-02 GO:0044249 cellular biosynthetic process
5.81 3.17e-02 GO:0043648 dicarboxylic acid metabolic process
4.34 3.18e-02 GO:0009145 purine nucleoside triphosphate biosynthetic process
4.34 3.18e-02 GO:0009201 ribonucleoside triphosphate biosynthetic process
1.44 3.27e-02 GO:0009058 biosynthetic process
2.48 3.68e-02 GO:0009141 nucleoside triphosphate metabolic process
4.59 4.10e-02 GO:0006754 ATP biosynthetic process
4.23 4.18e-02 GO:0009142 nucleoside triphosphate biosynthetic process
7.59 4.26e-02 GO:0007006 mitochondrial membrane organization
18.07 4.53e-02 GO:0034643 establishment of mitochondrion localization, microtubule-mediated
18.07 4.53e-02 GO:0047497 mitochondrion transport along microtubule
18.07 4.53e-02 GO:0051654 establishment of mitochondrion localization

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
4.43 1.44e-36 GO:0044429 mitochondrial part
3.19 2.44e-35 GO:0005739 mitochondrion
6.19 3.12e-32 GO:0005743 mitochondrial inner membrane
5.15 3.20e-32 GO:0031966 mitochondrial membrane
4.93 8.43e-31 GO:0005740 mitochondrial envelope
5.76 1.25e-30 GO:0019866 organelle inner membrane
1.50 7.24e-30 GO:0005737 cytoplasm
9.94 7.35e-30 GO:0044455 mitochondrial membrane part
3.71 3.91e-26 GO:0031975 envelope
3.73 4.67e-26 GO:0031967 organelle envelope
1.62 3.81e-24 GO:0044444 cytoplasmic part
11.09 2.65e-19 GO:0070469 respiratory chain
11.11 8.33e-18 GO:0005746 mitochondrial respiratory chain
1.26 6.26e-17 GO:0044424 intracellular part
1.23 3.42e-15 GO:0005622 intracellular
1.49 4.67e-13 GO:0044422 organelle part
1.48 1.71e-12 GO:0044446 intracellular organelle part
1.27 1.46e-11 GO:0043229 intracellular organelle
1.27 2.10e-11 GO:0043226 organelle
1.87 6.16e-11 GO:0031090 organelle membrane
1.29 2.94e-10 GO:0043231 intracellular membrane-bounded organelle
1.29 3.57e-10 GO:0043227 membrane-bounded organelle
3.80 3.87e-09 GO:0005759 mitochondrial matrix
1.56 9.72e-09 GO:0032991 macromolecular complex
9.73 1.64e-08 GO:0005747 mitochondrial respiratory chain complex I
9.73 1.64e-08 GO:0030964 NADH dehydrogenase complex
9.73 1.64e-08 GO:0045271 respiratory chain complex I
1.77 2.50e-08 GO:0005829 cytosol
1.57 5.17e-07 GO:0043234 protein complex
14.35 7.49e-07 GO:0005753 mitochondrial proton-transporting ATP synthase complex
12.84 2.66e-06 GO:0045259 proton-transporting ATP synthase complex
6.94 1.04e-04 GO:0016469 proton-transporting two-sector ATPase complex
14.79 3.22e-04 GO:0005744 mitochondrial inner membrane presequence translocase complex
1.07 4.25e-04 GO:0044464 cell part
1.07 4.34e-04 GO:0005623 cell
27.11 6.05e-04 GO:0005749 mitochondrial respiratory chain complex II
27.11 6.05e-04 GO:0045257 succinate dehydrogenase complex (ubiquinone)
27.11 6.05e-04 GO:0045273 respiratory chain complex II
27.11 6.05e-04 GO:0045281 succinate dehydrogenase complex
27.11 6.05e-04 GO:0045283 fumarate reductase complex
13.55 6.25e-04 GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o)
7.18 9.18e-04 GO:0042645 mitochondrial nucleoid
6.97 1.20e-03 GO:0009295 nucleoid
1.50 1.23e-03 GO:0031974 membrane-enclosed lumen
3.62 2.91e-03 GO:0031968 organelle outer membrane
3.50 4.45e-03 GO:0019867 outer membrane
1.47 4.61e-03 GO:0070013 intracellular organelle lumen
3.80 5.99e-03 GO:0005741 mitochondrial outer membrane
1.46 6.91e-03 GO:0043233 organelle lumen
2.30 9.99e-03 GO:0048471 perinuclear region of cytoplasm
1.38 2.53e-02 GO:0043228 non-membrane-bounded organelle
1.38 2.53e-02 GO:0043232 intracellular non-membrane-bounded organelle
7.75 2.76e-02 GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.38 2.20e-12 GO:0005515 protein binding
6.43 3.06e-10 GO:0015078 hydrogen ion transmembrane transporter activity
2.55 3.71e-09 GO:0016491 oxidoreductase activity
8.83 1.02e-07 GO:0016655 oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor
9.53 1.52e-07 GO:0003954 NADH dehydrogenase activity
9.53 1.52e-07 GO:0008137 NADH dehydrogenase (ubiquinone) activity
9.53 1.52e-07 GO:0050136 NADH dehydrogenase (quinone) activity
1.38 3.54e-07 GO:0003824 catalytic activity
5.69 2.34e-06 GO:0016651 oxidoreductase activity, acting on NADH or NADPH
3.38 4.92e-06 GO:0022890 inorganic cation transmembrane transporter activity
3.72 7.01e-06 GO:0015077 monovalent inorganic cation transmembrane transporter activity
27.11 8.31e-04 GO:0000104 succinate dehydrogenase activity
1.13 8.52e-04 GO:0005488 binding
3.19 2.24e-03 GO:0009055 electron carrier activity
2.69 5.26e-03 GO:0048037 cofactor binding
7.91 8.22e-03 GO:0004129 cytochrome-c oxidase activity
7.91 8.22e-03 GO:0015002 heme-copper terminal oxidase activity
7.91 8.22e-03 GO:0016675 oxidoreductase activity, acting on a heme group of donors
7.91 8.22e-03 GO:0016676 oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
27.11 2.25e-02 GO:0004449 isocitrate dehydrogenase (NAD+) activity
15.49 2.66e-02 GO:0008121 ubiquinol-cytochrome-c reductase activity
15.49 2.66e-02 GO:0016679 oxidoreductase activity, acting on diphenols and related substances as donors
15.49 2.66e-02 GO:0016681 oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor
9.68 4.63e-02 GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism