Motif ID: FOXA2.p3

Z-value: 1.816


Transcription factors associated with FOXA2.p3:

Gene SymbolEntrez IDGene Name
FOXA2 3170 forkhead box A2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
FOXA2chr20_-_225650500.486.7e-14Click!


Activity profile for motif FOXA2.p3.

activity profile for motif FOXA2.p3


Sorted Z-values histogram for motif FOXA2.p3

Sorted Z-values for motif FOXA2.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of FOXA2.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_-_15038724 43.435 NM_000900
NM_001190839
MGP

matrix Gla protein

chr17_-_26697224 36.676 VTN
vitronectin
chr17_-_26697310 32.739 VTN
vitronectin
chr12_-_91572328 29.142 NM_133504
NM_133505
NM_133506
NM_133507
DCN



decorin



chr4_-_69886112 27.907 NM_001075
NM_001144767
UGT2B10

UDP glucuronosyltransferase 2 family, polypeptide B10

chr17_-_26697293 26.487 VTN
vitronectin
chr12_-_9268440 25.651 A2M
alpha-2-macroglobulin
chr12_-_9268513 24.014 A2M
alpha-2-macroglobulin
chr4_-_70080448 23.824 NM_001073
UGT2B11
UGT2B10
UDP glucuronosyltransferase 2 family, polypeptide B11
UDP glucuronosyltransferase 2 family, polypeptide B10
chr12_-_9268475 21.833 A2M
alpha-2-macroglobulin
chrX_-_101112548 21.446 NM_032946
NXF5
nuclear RNA export factor 5
chr10_+_51549552 20.995 NM_002443
NM_138634
MSMB

microseminoprotein, beta-

chr4_+_70861647 19.551 NM_001009181
NM_003154
STATH

statherin

chr12_-_9268522 19.326 NM_000014
A2M
alpha-2-macroglobulin
chr12_-_71551564 18.973 TSPAN8
tetraspanin 8
chr17_-_10452939 17.804 NM_001100112
NM_017534
MYH2

myosin, heavy chain 2, skeletal muscle, adult

chr4_-_72671236 17.655 NM_001204306
GC
group-specific component (vitamin D binding protein)
chr2_-_21225640 17.640 APOB
apolipoprotein B (including Ag(x) antigen)
chr17_-_64225496 17.585 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr15_+_66874506 16.862


chr3_+_186330859 16.592 AHSG
alpha-2-HS-glycoprotein
chr17_-_26697358 16.250 NM_000638
VTN
vitronectin
chr22_+_21128378 15.566 NM_000185
SERPIND1
serpin peptidase inhibitor, clade D (heparin cofactor), member 1
chr3_+_186330844 15.212 NM_001622
AHSG
alpha-2-HS-glycoprotein
chr11_-_6462129 14.773 NM_000613
HPX
hemopexin
chr12_-_71551778 14.753 NM_004616
TSPAN8
tetraspanin 8
chr4_+_6695565 14.624 NM_005980
S100P
S100 calcium binding protein P
chr5_-_42811959 14.402 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr3_+_52811601 14.136 NM_002215
ITIH1
inter-alpha-trypsin inhibitor heavy chain 1
chr4_+_70146216 14.127 NM_001207004
NM_053039
UGT2B28

UDP glucuronosyltransferase 2 family, polypeptide B28

chr2_-_21266809 13.703 APOB
apolipoprotein B (including Ag(x) antigen)
chr1_-_20306908 13.265 NM_000300
NM_001161727
NM_001161728
PLA2G2A


phospholipase A2, group IIA (platelets, synovial fluid)


chr12_-_53343607 13.038 KRT8
keratin 8
chr10_+_124320180 12.900 NM_004406
NM_007329
NM_017579
DMBT1


deleted in malignant brain tumors 1


chr9_-_110251754 12.886 KLF4
Kruppel-like factor 4 (gut)
chr10_+_7745229 12.780 NM_002216
ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr1_-_203320249 12.619


chr10_+_7745284 12.357 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr10_+_7745341 12.198 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr1_-_203320185 12.163 FMOD
fibromodulin
chr1_-_57431620 12.052 NM_000066
C8B
complement component 8, beta polypeptide
chr4_-_72669757 11.680 NM_001204307
GC
group-specific component (vitamin D binding protein)
chr7_+_80267922 11.523 CD36
CD36 molecule (thrombospondin receptor)
chr10_+_7745325 11.238 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr11_-_63933204 11.151 MACROD1
MACRO domain containing 1
chr3_+_186330711 11.121 AHSG
alpha-2-HS-glycoprotein
chr2_-_216259197 11.088 FN1
fibronectin 1
chr9_-_110252045 11.057 NM_004235
KLF4
Kruppel-like factor 4 (gut)
chr11_+_62186506 10.968 NM_003357
SCGB1A1
secretoglobin, family 1A, member 1 (uteroglobin)
chr17_-_29641068 10.842 EVI2B
ecotropic viral integration site 2B
chr10_+_7745354 10.582 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr11_+_1151578 10.501 MUC5AC
mucin 5AC, oligomeric mucus/gel-forming
chr9_-_34710062 10.428 NM_002989
CCL21
chemokine (C-C motif) ligand 21
chr17_+_72427535 10.371 NM_022036
GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr1_-_203320287 10.334 NM_002023
FMOD
fibromodulin
chr1_-_161193375 10.307 NM_001643
APOA2
apolipoprotein A-II
chr9_-_95244634 10.173 ASPN
asporin
chr18_+_61254533 9.987 NM_012397
SERPINB13
serpin peptidase inhibitor, clade B (ovalbumin), member 13
chr2_-_21266915 9.956 NM_000384
APOB
apolipoprotein B (including Ag(x) antigen)
chr11_-_10590078 9.906 NM_006691
LYVE1
lymphatic vessel endothelial hyaluronan receptor 1
chr6_+_31895201 9.811 NM_000063
NM_001145903
C2

complement component 2

chr1_-_169555624 9.730 F5
coagulation factor V (proaccelerin, labile factor)
chr11_-_63933493 9.386 NM_014067
MACROD1
MACRO domain containing 1
chr4_+_69681709 9.381 NM_001075
NM_001144767
UGT2B10

UDP glucuronosyltransferase 2 family, polypeptide B10

chr1_+_207277577 9.278 NM_000715
C4BPA
complement component 4 binding protein, alpha
chr1_+_104198301 9.126 NM_004038
NM_001008218
NM_001008219
AMY1A
AMY1B
AMY1C
amylase, alpha 1A (salivary)
amylase, alpha 1B (salivary)
amylase, alpha 1C (salivary)
chr4_-_186456580 9.126 NM_001114107
NM_014476
PDLIM3

PDZ and LIM domain 3

chr10_-_81320141 9.113 NM_001098668
SFTPA1
SFTPA2
surfactant protein A1
surfactant protein A2
chr9_+_124048869 9.085 GSN
gelsolin
chr1_-_104238785 9.020 NM_004038
NM_001008218
NM_001008219
AMY1A
AMY1B
AMY1C
amylase, alpha 1A (salivary)
amylase, alpha 1B (salivary)
amylase, alpha 1C (salivary)
chr1_-_169555710 9.016 NM_000130
F5
coagulation factor V (proaccelerin, labile factor)
chr21_-_43735462 8.996 TFF3
trefoil factor 3 (intestinal)
chr9_-_75568232 8.977 NM_000689
ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr18_+_72922725 8.874 NM_005786
TSHZ1
teashirt zinc finger homeobox 1
chr4_-_70361578 8.857 NM_021139
UGT2B4
UDP glucuronosyltransferase 2 family, polypeptide B4
chr14_-_70263871 8.731 NM_003049
SLC10A1
solute carrier family 10 (sodium/bile acid cotransporter family), member 1
chr7_+_80267782 8.683 NM_000072
NM_001001548
CD36

CD36 molecule (thrombospondin receptor)

chr7_+_28452143 8.657 NM_182898
CREB5
cAMP responsive element binding protein 5
chr1_+_104292439 8.640 NM_004038
NM_001008218
NM_001008219
AMY1A
AMY1B
AMY1C
amylase, alpha 1A (salivary)
amylase, alpha 1B (salivary)
amylase, alpha 1C (salivary)
chr17_+_28268622 8.615 NM_198529
EFCAB5
EF-hand calcium binding domain 5
chr1_-_151345156 8.609 NM_003944
SELENBP1
selenium binding protein 1
chr9_-_116840673 8.553 NM_001633
AMBP
alpha-1-microglobulin/bikunin precursor
chr4_+_74281884 8.553 ALB
albumin
chr18_+_29171729 8.483 NM_000371
TTR
transthyretin
chr7_+_80231503 8.456 NM_001001547
CD36
CD36 molecule (thrombospondin receptor)
chr20_-_43883183 8.421 NM_003064
SLPI
secretory leukocyte peptidase inhibitor
chr4_+_71248794 8.301 NM_006685
SMR3B
submaxillary gland androgen regulated protein 3B
chr11_-_107582733 8.229 NM_003063
SLN
sarcolipin
chr1_-_115238091 8.011 NM_000036
NM_001172626
AMPD1

adenosine monophosphate deaminase 1

chr11_-_108464344 7.914 NM_015065
EXPH5
exophilin 5
chr9_-_112191105 7.863 NM_001145371
NM_001145372
PTPN3

protein tyrosine phosphatase, non-receptor type 3

chr12_-_102591547 7.592 NM_002674
PMCH
pro-melanin-concentrating hormone
chr7_-_50628744 7.500 NM_000790
NM_001242886
NM_001242887
NM_001242888
NM_001242889
NM_001242890
DDC





dopa decarboxylase (aromatic L-amino acid decarboxylase)





chr3_-_148939784 7.414 NM_000096
CP
ceruloplasmin (ferroxidase)
chrX_+_24167728 7.361 NM_001178086
NM_001178095
NM_001178084
NM_001178085
NM_003410
ZFX




zinc finger protein, X-linked




chr4_+_71062241 7.357 NM_017855
ODAM
odontogenic, ameloblast asssociated
chr20_+_31823801 7.309 NM_001243193
NM_016583
NM_130852
BPIFA1


BPI fold containing family A, member 1


chr4_-_71532341 7.167 NM_144646
IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr6_-_41715078 7.158 NM_001166424
NM_002630
PGC

progastricsin (pepsinogen C)

chrX_+_99839789 7.157 NM_022144
TNMD
tenomodulin
chr7_+_28338939 7.134 NM_182899
CREB5
cAMP responsive element binding protein 5
chr6_-_49712055 7.089 NM_001190986
NM_006061
CRISP3

cysteine-rich secretory protein 3

chr6_+_101846668 7.058 GRIK2
glutamate receptor, ionotropic, kainate 2
chr2_+_211421322 6.875 NM_001875
CPS1
carbamoyl-phosphate synthase 1, mitochondrial
chr21_-_47743753 6.847 NM_058180
C21orf58
chromosome 21 open reading frame 58
chr10_+_115310589 6.805 NM_001177660
HABP2
hyaluronan binding protein 2
chr21_-_43786602 6.794 NM_003225
TFF1
trefoil factor 1
chr22_-_36019363 6.649 NM_203377
MB
myoglobin
chr3_+_69985750 6.635 NM_000248
NM_001184968
NM_198158
NM_198178
MITF



microphthalmia-associated transcription factor



chr6_-_46922533 6.468 NM_015234
GPR116
G protein-coupled receptor 116
chr4_+_156824846 6.461 NM_005651
TDO2
tryptophan 2,3-dioxygenase
chr10_-_54531394 6.406 NM_000242
MBL2
mannose-binding lectin (protein C) 2, soluble
chr9_-_3525973 6.399 NM_002919
NM_134428
RFX3

regulatory factor X, 3 (influences HLA class II expression)

chr7_+_80275967 6.358 CD36
CD36 molecule (thrombospondin receptor)
chr14_-_94789641 6.337 NM_001756
SERPINA6
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
chr21_-_43735705 6.318 NM_003226
TFF3
trefoil factor 3 (intestinal)
chr15_+_96869156 6.279 NM_001145155
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr14_-_38064176 6.267 FOXA1
forkhead box A1
chr21_-_31588242 6.249 NM_199328
CLDN8
claudin 8
chr6_-_25930838 6.181 NM_005835
SLC17A2
solute carrier family 17 (sodium phosphate), member 2
chrX_-_65259839 6.176 NM_001100431
NM_001184830
NM_001184831
NM_007268
VSIG4



V-set and immunoglobulin domain containing 4



chr6_-_31845446 6.162 NM_001178045
SLC44A4
solute carrier family 44, member 4
chr17_-_7017971 6.157 ASGR2
asialoglycoprotein receptor 2
chr7_+_134576150 6.136 NM_033139
NM_033140
CALD1

caldesmon 1

chr13_-_48987017 6.133 LPAR6
lysophosphatidic acid receptor 6
chr4_+_187148624 6.094 NM_000892
KLKB1
kallikrein B, plasma (Fletcher factor) 1
chr14_-_36988902 5.995 NM_003317
NKX2-1
NK2 homeobox 1
chr17_-_19290471 5.965 NM_001198695
NM_002404
MFAP4

microfibrillar-associated protein 4

chr3_+_148545587 5.943 NM_001871
CPB1
carboxypeptidase B1 (tissue)
chrX_+_24167861 5.938 ZFX
zinc finger protein, X-linked
chr4_+_55095263 5.937 NM_006206
PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr19_+_41430123 5.936 CYP2B7P1
cytochrome P450, family 2, subfamily B, polypeptide 7 pseudogene 1
chr3_+_189349215 5.927 NM_001114978
NM_001114979
NM_003722
TP63


tumor protein p63


chrX_+_57618268 5.914 NM_007157
ZXDB
zinc finger, X-linked, duplicated B
chr1_+_54359859 5.901 NM_000792
NM_001039715
NM_001039716
NM_213593
DIO1



deiodinase, iodothyronine, type I



chr6_-_90024936 5.720 NM_002043
GABRR2
gamma-aminobutyric acid (GABA) receptor, rho 2
chr9_-_116840604 5.711 AMBP
alpha-1-microglobulin/bikunin precursor
chr4_+_88720701 5.687 NM_004967
IBSP
integrin-binding sialoprotein
chr2_+_234545099 5.686 NM_019075
UGT1A10
UDP glucuronosyltransferase 1 family, polypeptide A10
chr4_-_186732208 5.661 NM_001145671
SORBS2
sorbin and SH3 domain containing 2
chr19_-_45909566 5.594 NM_001142502
PPP1R13L
protein phosphatase 1, regulatory subunit 13 like
chr3_-_120401401 5.590 NM_000187
HGD
homogentisate 1,2-dioxygenase
chr4_-_71532206 5.552 IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr6_+_55039070 5.547 NM_001526
HCRTR2
hypocretin (orexin) receptor 2
chr1_+_226016428 5.542 EPHX1
epoxide hydrolase 1, microsomal (xenobiotic)
chr10_-_45474210 5.537 NM_007021
C10orf10
chromosome 10 open reading frame 10
chr17_-_46035109 5.536 NM_024320
PRR15L
proline rich 15-like
chrX_-_15288172 5.534 NM_001031739
NM_001168530
NM_024087
ASB9


ankyrin repeat and SOCS box containing 9


chr7_+_129906702 5.529 NM_001869
CPA2
carboxypeptidase A2 (pancreatic)
chrX_+_15518899 5.490 NM_203281
BMX
BMX non-receptor tyrosine kinase
chr1_+_104159953 5.475 NM_000699
AMY2A
amylase, alpha 2A (pancreatic)
chr10_+_95848811 5.437 NM_001165979
PLCE1
phospholipase C, epsilon 1
chr9_-_95244750 5.417 NM_001193335
NM_017680
ASPN

asporin

chr7_-_115670774 5.406 TFEC
transcription factor EC
chr2_+_113875469 5.383 NM_000577
NM_173841
NM_173843
IL1RN


interleukin 1 receptor antagonist


chr4_+_72102249 5.379 SLC4A4
solute carrier family 4, sodium bicarbonate cotransporter, member 4
chr3_-_120400957 5.378 HGD
homogentisate 1,2-dioxygenase
chr11_+_844445 5.345 NM_001025237
TSPAN4
tetraspanin 4
chr12_-_120765555 5.232 NM_000928
PLA2G1B
phospholipase A2, group IB (pancreas)
chr17_+_41006094 5.211 AOC3
amine oxidase, copper containing 3 (vascular adhesion protein 1)
chr1_+_13911966 5.182 NM_001006624
NM_001006625
PDPN

podoplanin

chr11_-_102401430 5.154 NM_002423
MMP7
matrix metallopeptidase 7 (matrilysin, uterine)
chr18_-_3874688 5.142 NM_001242762
NM_001242763
DLGAP1

discs, large (Drosophila) homolog-associated protein 1

chr2_-_21266893 5.136 APOB
apolipoprotein B (including Ag(x) antigen)
chr6_+_161123224 5.136 NM_000301
NM_001168338
PLG

plasminogen

chr4_+_140586921 5.108 NM_001204366
NM_001204367
NM_001204368
NM_002413
MGST2



microsomal glutathione S-transferase 2



chr6_-_112575880 5.064 LAMA4
laminin, alpha 4
chr6_-_112575766 5.024 NM_001105206
NM_001105207
NM_001105208
NM_001105209
NM_002290
LAMA4




laminin, alpha 4




chr5_-_41213513 4.975 NM_000065
C6
complement component 6
chr1_+_227127993 4.960 ADCK3
aarF domain containing kinase 3
chr13_-_48987247 4.954 LPAR6
lysophosphatidic acid receptor 6
chr11_+_88911039 4.952 NM_000372
TYR
tyrosinase (oculocutaneous albinism IA)
chr4_-_100242487 4.948 NM_000668
ADH1A
ADH1B
alcohol dehydrogenase 1A (class I), alpha polypeptide
alcohol dehydrogenase 1B (class I), beta polypeptide
chr6_+_135502521 4.943 MYB
v-myb myeloblastosis viral oncogene homolog (avian)
chr3_-_168864066 4.923 NM_001105077
NM_001163999
NM_005241
MECOM


MDS1 and EVI1 complex locus


chr4_-_123542165 4.910 NM_001207006
NM_021803
IL21

interleukin 21

chr14_+_37131064 4.891 PAX9
paired box 9
chr6_-_108145507 4.890 NM_198081
SCML4
sex comb on midleg-like 4 (Drosophila)
chr4_+_55095433 4.855 PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr9_+_129724503 4.844 NM_001190728
RALGPS1
Ral GEF with PH domain and SH3 binding motif 1
chr4_+_175839508 4.825 NM_001130703
NM_001130704
NM_001130705
NM_014269
ADAM29



ADAM metallopeptidase domain 29



chr2_-_211018294 4.825 C2orf67
chromosome 2 open reading frame 67
chr2_+_74120092 4.807 NM_001199893
NM_001615
ACTG2

actin, gamma 2, smooth muscle, enteric

chr7_+_134576187 4.806 CALD1
caldesmon 1
chr4_+_88529680 4.806 NM_014208
DSPP
dentin sialophosphoprotein
chr3_+_178276487 4.768 NM_005832
KCNMB2
potassium large conductance calcium-activated channel, subfamily M, beta member 2
chr13_+_78109808 4.757 NM_001160706
NM_003843
NM_144777
SCEL


sciellin


chr2_+_113885137 4.743 NM_173842
IL1RN
interleukin 1 receptor antagonist
chr14_+_21359542 4.740 NM_002935
RNASE3
ribonuclease, RNase A family, 3
chr4_-_100356290 4.734 NM_001166504
ADH7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr9_-_21368005 4.718 NM_006900
IFNA1
IFNA13
interferon, alpha 1
interferon, alpha 13
chr9_-_14722669 4.718 NM_005454
CER1
cerberus 1, cysteine knot superfamily, homolog (Xenopus laevis)
chr7_-_107443631 4.709 NM_000111
SLC26A3
solute carrier family 26, member 3
chr4_+_155484131 4.661 NM_001184741
NM_005141
FGB

fibrinogen beta chain

chrX_+_91089658 4.646 NM_014522
NM_032968
NM_032969
PCDH11X


protocadherin 11 X-linked


chr7_-_27135524 4.629 NM_005522
NM_153620
HOXA1

homeobox A1

chr12_+_121416548 4.623 NM_000545
HNF1A
HNF1 homeobox A
chr7_+_100199881 4.576 NM_002593
PCOLCE
procollagen C-endopeptidase enhancer
chr10_+_71561687 4.547 COL13A1
collagen, type XIII, alpha 1
chr19_+_18496966 4.541 NM_004864
GDF15
growth differentiation factor 15

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.38 3.82e-12 GO:0050896 response to stimulus
1.43 1.92e-11 GO:0032501 multicellular organismal process
1.52 1.62e-10 GO:0023052 signaling
1.48 2.06e-07 GO:0007165 signal transduction
1.41 4.37e-07 GO:0051716 cellular response to stimulus
1.65 6.37e-06 GO:0007166 cell surface receptor linked signaling pathway
1.23 6.80e-06 GO:0065007 biological regulation
1.56 7.50e-06 GO:0042221 response to chemical stimulus
1.94 1.90e-05 GO:0009611 response to wounding
1.56 1.92e-05 GO:0065008 regulation of biological quality
1.14 6.42e-05 GO:0009987 cellular process
1.95 7.24e-05 GO:0006952 defense response
4.20 8.93e-05 GO:0007586 digestion
6.26 1.45e-04 GO:0031214 biomineral tissue development
3.41 5.04e-04 GO:0006805 xenobiotic metabolic process
3.41 5.04e-04 GO:0071466 cellular response to xenobiotic stimulus
3.39 5.79e-04 GO:0009410 response to xenobiotic stimulus
2.10 6.42e-04 GO:0007186 G-protein coupled receptor protein signaling pathway
9.87 8.74e-04 GO:0015721 bile acid and bile salt transport
5.34 1.14e-03 GO:0045807 positive regulation of endocytosis
2.03 1.83e-03 GO:0050878 regulation of body fluid levels
1.20 1.97e-03 GO:0050789 regulation of biological process
2.10 2.37e-03 GO:0007599 hemostasis
2.16 2.40e-03 GO:0050776 regulation of immune response
1.99 2.48e-03 GO:0042060 wound healing
1.65 2.58e-03 GO:0002376 immune system process
5.87 3.13e-03 GO:0008206 bile acid metabolic process
4.53 3.74e-03 GO:0072376 protein activation cascade
1.84 3.91e-03 GO:0007267 cell-cell signaling
1.42 4.43e-03 GO:0006950 response to stress
2.07 4.59e-03 GO:0007596 blood coagulation
2.07 4.59e-03 GO:0050817 coagulation
1.83 6.24e-03 GO:0006955 immune response
2.04 6.62e-03 GO:0001775 cell activation
2.37 1.19e-02 GO:0006954 inflammatory response
1.49 1.41e-02 GO:0003008 system process
10.76 1.43e-02 GO:0006067 ethanol metabolic process
10.76 1.43e-02 GO:0006069 ethanol oxidation
10.76 1.43e-02 GO:0034308 primary alcohol metabolic process
2.52 1.45e-02 GO:0008202 steroid metabolic process
1.69 1.54e-02 GO:0042127 regulation of cell proliferation
2.47 1.55e-02 GO:0051241 negative regulation of multicellular organismal process
2.02 1.85e-02 GO:0072358 cardiovascular system development
2.02 1.85e-02 GO:0072359 circulatory system development
4.14 2.54e-02 GO:0015718 monocarboxylic acid transport
1.65 2.60e-02 GO:0007154 cell communication
2.66 2.66e-02 GO:0006725 cellular aromatic compound metabolic process
1.29 3.44e-02 GO:0032502 developmental process
12.33 3.78e-02 GO:0070168 negative regulation of biomineral tissue development
2.03 3.79e-02 GO:0008285 negative regulation of cell proliferation
1.78 3.79e-02 GO:0002682 regulation of immune system process
1.30 4.90e-02 GO:0007275 multicellular organismal development
2.95 4.93e-02 GO:0001503 ossification

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.61 7.68e-22 GO:0044421 extracellular region part
2.02 2.00e-20 GO:0005576 extracellular region
2.65 5.02e-17 GO:0005615 extracellular space
1.73 1.04e-11 GO:0044459 plasma membrane part
1.99 8.62e-11 GO:0005887 integral to plasma membrane
1.96 3.09e-10 GO:0031226 intrinsic to plasma membrane
2.90 7.75e-10 GO:0031012 extracellular matrix
2.84 1.15e-07 GO:0005578 proteinaceous extracellular matrix
1.35 4.68e-06 GO:0005886 plasma membrane
1.79 6.70e-06 GO:0000267 cell fraction
1.34 1.20e-05 GO:0071944 cell periphery
1.90 1.51e-05 GO:0005626 insoluble fraction
1.91 1.83e-05 GO:0005624 membrane fraction
2.45 2.45e-03 GO:0005792 microsome
4.55 2.60e-03 GO:0031983 vesicle lumen
2.37 4.69e-03 GO:0042598 vesicular fraction
4.34 9.96e-03 GO:0060205 cytoplasmic membrane-bounded vesicle lumen
4.20 3.07e-02 GO:0031093 platelet alpha granule lumen
3.81 3.56e-02 GO:0031091 platelet alpha granule
4.11 3.70e-02 GO:0034774 secretory granule lumen

Gene overrepresentation in function category:

enrichment   p-value GO term description
4.19 2.25e-04 GO:0005201 extracellular matrix structural constituent
13.15 6.76e-04 GO:0004022 alcohol dehydrogenase (NAD) activity
4.93 4.82e-03 GO:0043498 cell surface binding
1.63 5.60e-03 GO:0005102 receptor binding
4.31 8.55e-03 GO:0042562 hormone binding
12.33 8.98e-03 GO:0005132 interferon-alpha/beta receptor binding
2.82 9.08e-03 GO:0005539 glycosaminoglycan binding
3.10 2.87e-02 GO:0004222 metalloendopeptidase activity
2.61 2.99e-02 GO:0001871 pattern binding
2.61 2.99e-02 GO:0030247 polysaccharide binding
3.82 3.04e-02 GO:0005319 lipid transporter activity