Motif ID: FOXD3.p2

Z-value: 2.035


Transcription factors associated with FOXD3.p2:

Gene SymbolEntrez IDGene Name
FOXD3 27022 forkhead box D3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
FOXD3chr1_+_63788729-0.551.7e-18Click!


Activity profile for motif FOXD3.p2.

activity profile for motif FOXD3.p2


Sorted Z-values histogram for motif FOXD3.p2

Sorted Z-values for motif FOXD3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOXD3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_+_123234462 98.392 STAG2
stromal antigen 2
chr5_+_159436143 91.677 TTC1
tetratricopeptide repeat domain 1
chr11_-_16996559 86.757 RPL36A
ribosomal protein L36a
chr11_-_67450536 80.088 RPL37
ribosomal protein L37
chr12_+_27175482 61.870 NM_004264
MED21
mediator complex subunit 21
chr6_+_74171610 60.147 MTO1
mitochondrial translation optimization 1 homolog (S. cerevisiae)
chr2_+_216176808 59.672 ATIC
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
chr7_-_87849341 58.258 SRI
sorcin
chr4_+_146031528 56.972 ABCE1
ATP-binding cassette, sub-family E (OABP), member 1
chr2_-_47134945 56.556 MCFD2
multiple coagulation factor deficiency 2
chr14_+_102276125 53.752 NM_002719
NM_178586
NM_178587
PPP2R5C


protein phosphatase 2, regulatory subunit B', gamma


chr3_+_172472246 52.583 NM_018098
ECT2
epithelial cell transforming sequence 2 oncogene
chr2_+_216176678 52.046 NM_004044
ATIC
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
chr5_+_159436155 49.728 NM_003314
TTC1
tetratricopeptide repeat domain 1
chr2_+_216176818 49.619 ATIC
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
chr6_-_150057659 49.419 NUP43
nucleoporin 43kDa
chr22_-_43036606 47.743 NM_001165877
ATP5L2
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit G2
chr3_-_25683825 47.395 TOP2B
topoisomerase (DNA) II beta 180kDa
chr16_+_30064410 46.386 NM_000034
ALDOA
aldolase A, fructose-bisphosphate
chr20_+_19870209 45.230 NM_018993
RIN2
Ras and Rab interactor 2
chr14_+_67831484 44.787 EIF2S1
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
chr1_-_108786663 44.300 NM_001143989
NBPF4
NBPF6
neuroblastoma breakpoint family, member 4
neuroblastoma breakpoint family, member 6
chr16_+_30064470 43.790 ALDOA
aldolase A, fructose-bisphosphate
chr7_+_6617035 43.781 NM_001134387
NM_001134388
NM_001134389
NM_018106
ZDHHC4



zinc finger, DHHC-type containing 4



chr2_+_109204904 43.150 NM_001193488
LIMS1
LIM and senescent cell antigen-like domains 1
chrX_+_118714297 42.686 NM_181777
UBE2A
ubiquitin-conjugating enzyme E2A
chr1_+_40735749 42.664 ZMPSTE24
zinc metallopeptidase (STE24 homolog, S. cerevisiae)
chr4_-_83347222 42.075 HNRPDL
heterogeneous nuclear ribonucleoprotein D-like
chr9_+_75766777 40.190 NM_000700
ANXA1
annexin A1
chr11_-_17191287 40.082 NM_002645
PIK3C2A
phosphoinositide-3-kinase, class 2, alpha polypeptide
chr12_-_102512277 39.273 NM_024057
NUP37
nucleoporin 37kDa
chr13_-_37679800 38.788 NM_145203
CSNK1A1L
casein kinase 1, alpha 1-like
chr15_-_66648991 38.485 NM_017858
TIPIN
TIMELESS interacting protein
chr20_+_19915716 37.646 RIN2
Ras and Rab interactor 2
chr8_+_132991171 37.608 EFR3A
EFR3 homolog A (S. cerevisiae)
chr2_+_109204745 37.532 NM_004987
LIMS1
LIM and senescent cell antigen-like domains 1
chr15_-_72501017 37.106 PKM2
pyruvate kinase, muscle
chr5_+_132406080 36.971 HSPA4
heat shock 70kDa protein 4
chr9_+_75766794 36.245 ANXA1
annexin A1
chr6_+_74171453 35.548 NM_001123226
NM_012123
NM_133645
MTO1


mitochondrial translation optimization 1 homolog (S. cerevisiae)


chr2_+_109204777 35.501 LIMS1
LIM and senescent cell antigen-like domains 1
chr12_-_46633551 34.577 SLC38A1
solute carrier family 38, member 1
chrX_-_102942968 34.559 NM_001142419
NM_001142420
NM_001142421
NM_001142422
NM_001142427
NM_001142428
NM_001142431
NM_001142432
MORF4L2







mortality factor 4 like 2







chrX_-_129272014 34.074 NM_001130846
AIFM1
apoptosis-inducing factor, mitochondrion-associated, 1
chr6_-_38670829 34.018 GLO1
glyoxalase I
chr2_-_85637486 33.674 NM_001747
CAPG
capping protein (actin filament), gelsolin-like
chr19_+_13134782 33.405 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr6_-_38670882 32.874 GLO1
glyoxalase I
chr10_-_931694 31.658 NM_015155
LARP4B
La ribonucleoprotein domain family, member 4B
chr14_+_102276279 31.477 PPP2R5C
protein phosphatase 2, regulatory subunit B', gamma
chr12_+_64803741 31.330 XPOT
exportin, tRNA (nuclear export receptor for tRNAs)
chr2_-_20527120 31.172 NM_015317
PUM2
pumilio homolog 2 (Drosophila)
chr6_-_75965845 30.814 TMEM30A
transmembrane protein 30A
chr16_-_28437663 30.795 NM_001199142
EIF3C
eukaryotic translation initiation factor 3, subunit C
chr11_+_18415917 30.692 NM_001135239
NM_001165415
NM_001165416
NM_005566
LDHA



lactate dehydrogenase A



chr20_+_48552928 29.731 RNF114
ring finger protein 114
chr20_+_48552902 29.539 NM_018683
RNF114
ring finger protein 114
chr20_-_5107185 29.050 NM_002592
PCNA
proliferating cell nuclear antigen
chr16_+_28699878 28.988 NM_001199142
EIF3C
eukaryotic translation initiation factor 3, subunit C
chr14_-_75600111 28.800 TMED10
transmembrane emp24-like trafficking protein 10 (yeast)
chr14_+_56078735 28.679 KTN1
kinectin 1 (kinesin receptor)
chr21_-_27512668 28.613 NM_001136016
APP
amyloid beta (A4) precursor protein
chr11_-_88070901 28.204 CTSC
cathepsin C
chr12_+_32832209 28.013 DNM1L
dynamin 1-like
chr12_+_32832128 27.993 NM_005690
NM_012062
NM_012063
DNM1L


dynamin 1-like


chr1_-_150669499 27.947 NM_018178
GOLPH3L
golgi phosphoprotein 3-like
chr1_+_74701070 27.641 NM_015978
TNNI3K
TNNI3 interacting kinase
chr5_+_34687663 27.108 NM_001145523
RAI14
retinoic acid induced 14
chr1_-_77685076 26.959 NM_005482
PIGK
phosphatidylinositol glycan anchor biosynthesis, class K
chr15_+_80390757 26.844 NM_001242919
ZFAND6
zinc finger, AN1-type domain 6
chr12_+_32832272 26.682 DNM1L
dynamin 1-like
chr11_-_88070840 26.608 CTSC
cathepsin C
chr6_-_38670904 26.581 GLO1
glyoxalase I
chr19_+_11200037 26.519 NM_000527
NM_001195798
NM_001195799
NM_001195800
NM_001195802
NM_001195803
LDLR





low density lipoprotein receptor





chr5_+_132432880 26.403 HSPA4
heat shock 70kDa protein 4
chr3_-_149086884 26.236 TM4SF1
transmembrane 4 L six family member 1
chr12_+_13043955 26.123 NM_003979
GPRC5A
G protein-coupled receptor, family C, group 5, member A
chr6_-_38670871 25.963 GLO1
glyoxalase I
chr18_+_33234532 25.903 NM_020474
GALNT1
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1)
chr16_-_47005339 25.599 DNAJA2
DnaJ (Hsp40) homolog, subfamily A, member 2
chr10_-_98336445 25.565 TM9SF3
transmembrane 9 superfamily member 3
chr10_+_112344076 25.386 SMC3
structural maintenance of chromosomes 3
chr11_+_125495030 25.336 NM_001114121
NM_001114122
NM_001244846
CHEK1


checkpoint kinase 1


chr8_+_66582107 25.183 NM_001145838
MTFR1
mitochondrial fission regulator 1
chr5_+_147795459 25.048 FBXO38
F-box protein 38
chr12_+_27175501 24.935 MED21
mediator complex subunit 21
chr6_-_42185599 24.785 MRPS10
mitochondrial ribosomal protein S10
chr1_+_24018268 24.669 NM_000975
NM_001199802
RPL11

ribosomal protein L11

chr3_+_9476506 24.563


chr19_+_10362598 24.369 NM_015956
NM_146387
NM_146388
MRPL4


mitochondrial ribosomal protein L4


chr6_-_38670915 24.327 GLO1
glyoxalase I
chr13_-_41593405 24.086 ELF1
E74-like factor 1 (ets domain transcription factor)
chr13_+_52598678 23.873 NM_021645
ALG11
UTP14C
asparagine-linked glycosylation 11, alpha-1,2-mannosyltransferase homolog (yeast)
UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast)
chr20_+_48552935 23.758 RNF114
ring finger protein 114
chr13_+_53035227 23.677 CKAP2
cytoskeleton associated protein 2
chr13_-_41593491 23.573 NM_172373
ELF1
E74-like factor 1 (ets domain transcription factor)
chr5_-_111091947 23.538 NM_001142483
C5orf13
chromosome 5 open reading frame 13
chr6_-_42185586 23.438 MRPS10
mitochondrial ribosomal protein S10
chr17_+_65714038 23.096 NM_015462
NOL11
nucleolar protein 11
chr10_-_98325100 23.095 TM9SF3
transmembrane 9 superfamily member 3
chr6_+_64356430 23.045 NM_015153
PHF3
PHD finger protein 3
chr17_+_26646120 22.974 NM_014573
TMEM97
transmembrane protein 97
chr7_-_96339074 22.670 SHFM1
split hand/foot malformation (ectrodactyly) type 1
chr2_-_86948244 22.493 NM_001198954
RNF103-CHMP3
RNF103-CHMP3 readthrough
chr10_-_27057776 22.437 ABI1
abl-interactor 1
chr8_-_80993009 22.379 NM_001025252
TPD52
tumor protein D52
chr11_-_88070905 22.105 NM_001114173
NM_001814
NM_148170
CTSC


cathepsin C


chr9_+_79968344 22.082 VPS13A
vacuolar protein sorting 13 homolog A (S. cerevisiae)
chr21_+_30400229 21.751 USP16
ubiquitin specific peptidase 16
chr5_+_96212167 21.649 ERAP2
endoplasmic reticulum aminopeptidase 2
chr6_-_159240367 21.647 EZR
ezrin
chr4_-_84035888 21.596 PLAC8
placenta-specific 8
chr2_-_225370687 21.575 CUL3
cullin 3
chr3_+_142375738 21.256 NM_001172312
PLS1
plastin 1
chr15_-_55562483 20.958 NM_183234
NM_004580
RAB27A

RAB27A, member RAS oncogene family

chr9_-_130700762 20.853 NM_003863
DPM2
dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit
chr1_+_24018293 20.654 RPL11
ribosomal protein L11
chrX_+_70765479 20.630 OGT
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
chr6_-_159240433 20.630 NM_001111077
EZR
ezrin
chr11_-_64578765 20.576 NM_130803
NM_130804
MEN1

multiple endocrine neoplasia I

chr6_-_38670922 20.566 NM_006708
GLO1
glyoxalase I
chr9_+_110047049 20.480 NM_001244713
RAD23B
RAD23 homolog B (S. cerevisiae)
chr9_-_88715024 20.462 NM_177937
GOLM1
golgi membrane protein 1
chr1_-_154578775 20.287 NM_001193495
ADAR
adenosine deaminase, RNA-specific
chr3_+_133502876 20.116 NM_021203
SRPRB
signal recognition particle receptor, B subunit
chr3_-_105421044 20.084 CBLB
Cas-Br-M (murine) ecotropic retroviral transforming sequence b
chr2_+_109384601 20.056 RANBP2
RAN binding protein 2
chr2_-_151344145 20.053 NM_005168
RND3
Rho family GTPase 3
chr2_-_170430312 20.048 NM_024622
FASTKD1
FAST kinase domains 1
chr17_-_42144986 20.019 NM_152344
LSM12
LSM12 homolog (S. cerevisiae)
chr15_+_80364902 19.870 NM_001242915
NM_001242916
ZFAND6

zinc finger, AN1-type domain 6

chr8_-_30585442 19.849 NM_000637
NM_001195102
NM_001195103
NM_001195104
GSR



glutathione reductase



chr1_+_46016454 19.800 NM_001202413
NM_001202414
NM_006066
NM_153326
AKR1A1



aldo-keto reductase family 1, member A1 (aldehyde reductase)



chr10_-_126849010 19.766 CTBP2
C-terminal binding protein 2
chr5_+_70944968 19.764 MCCC2
methylcrotonoyl-CoA carboxylase 2 (beta)
chr9_+_118916069 19.678 NM_002581
PAPPA
pregnancy-associated plasma protein A, pappalysin 1
chr7_+_28475233 19.677 NM_004904
CREB5
cAMP responsive element binding protein 5
chr15_+_64680002 19.436 NM_016213
TRIP4
thyroid hormone receptor interactor 4
chr12_+_2904289 19.304 FKBP4
FK506 binding protein 4, 59kDa
chr4_-_84035908 19.274 NM_001130715
NM_016619
PLAC8

placenta-specific 8

chrX_+_119737905 19.144 MCTS1
malignant T cell amplified sequence 1
chr5_+_159848835 19.016 NM_004219
PTTG1
pituitary tumor-transforming 1
chr3_+_172468469 19.011 ECT2
epithelial cell transforming sequence 2 oncogene
chr20_-_31989303 19.006 CDK5RAP1
CDK5 regulatory subunit associated protein 1
chr6_-_42185603 19.003 NM_018141
MRPS10
mitochondrial ribosomal protein S10
chr2_+_172821874 18.768 HAT1
histone acetyltransferase 1
chr2_+_201170603 18.357 NM_015535
SPATS2L
spermatogenesis associated, serine-rich 2-like
chr15_+_57511616 18.302 NM_207040
TCF12
transcription factor 12
chr4_+_41614725 18.288 LIMCH1
LIM and calponin homology domains 1
chr7_+_77469446 18.241 NM_001127357
NM_001127359
NM_020432
PHTF2


putative homeodomain transcription factor 2


chr4_-_139163222 18.229 NM_014331
SLC7A11
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
chr15_-_60690115 18.188 NM_001002857
NM_001002858
NM_001136015
NM_004039
ANXA2



annexin A2



chr6_-_159240398 18.160 EZR
ezrin
chr11_+_87032428 18.055 TMEM135
transmembrane protein 135
chr1_+_44064509 17.969 PTPRF
protein tyrosine phosphatase, receptor type, F
chr14_+_39649711 17.955 PNN
pinin, desmosome associated protein
chrX_-_23855456 17.860 RPL9
ribosomal protein L9
chr17_-_48945338 17.818 NM_001243877
TOB1
transducer of ERBB2, 1
chr18_-_47814691 17.725 NM_001101654
NM_014593
CXXC1

CXXC finger protein 1

chr15_-_42749710 17.351 NM_022473
ZFP106
zinc finger protein 106 homolog (mouse)
chr14_+_67656109 17.330 NM_173526
FAM71D
family with sequence similarity 71, member D
chr6_-_31830551 17.062 NEU1
sialidase 1 (lysosomal sialidase)
chr2_+_201170795 17.038 NM_001100422
NM_001100424
NM_001100423
SPATS2L


spermatogenesis associated, serine-rich 2-like


chr12_+_56915587 16.849 NM_002898
RBMS2
RNA binding motif, single stranded interacting protein 2
chr3_+_130569368 16.666 NM_001199180
NM_001199181
NM_001199182
ATP2C1


ATPase, Ca++ transporting, type 2C, member 1


chr4_-_76878558 16.385 SDAD1
SDA1 domain containing 1
chr17_-_7578810 16.325 NM_001126115
NM_001126116
NM_001126117
TP53


tumor protein p53


chr20_-_31989330 16.208 NM_016082
NM_016408
CDK5RAP1

CDK5 regulatory subunit associated protein 1

chr22_-_43355886 16.171 NM_001184971
PACSIN2
protein kinase C and casein kinase substrate in neurons 2
chr19_+_1026271 16.143 NM_004368
NM_201277
CNN2

calponin 2

chr11_+_69467210 16.142 CCND1
cyclin D1
chr16_-_23607603 16.023 NM_005003
NDUFAB1
NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa
chr7_+_28725597 16.020 NM_001011666
CREB5
cAMP responsive element binding protein 5
chr18_+_9102618 15.976 NM_021074
NDUFV2
NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa
chr1_-_161147757 15.905 NM_001199873
NM_001199874
NM_003779
B4GALT3


UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3


chr17_-_30228715 15.769 NM_018428
UTP6
UTP6, small subunit (SSU) processome component, homolog (yeast)
chr9_+_127962850 15.684 NM_005833
RABEPK
Rab9 effector protein with kelch motifs
chr5_-_68665839 15.638 NM_001015891
NM_001015892
TAF9

TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa

chr2_-_152146373 15.632 NM_004688
NMI
N-myc (and STAT) interactor
chr6_-_159240399 15.574 EZR
ezrin
chr8_-_6420454 15.546 NM_001118887
NM_001118888
NM_001147
ANGPT2


angiopoietin 2


chr3_-_189838673 15.503 LEPREL1
leprecan-like 1
chr19_-_39826676 15.332 NM_004877
GMFG
glia maturation factor, gamma
chr3_-_15839674 15.298 NM_001195098
ANKRD28
ankyrin repeat domain 28
chr6_-_127664511 15.275 ECHDC1
enoyl CoA hydratase domain containing 1
chr2_-_74382352 15.265


chrX_+_119737743 15.258 NM_014060
MCTS1
malignant T cell amplified sequence 1
chr2_+_183582667 15.210 DNAJC10
DnaJ (Hsp40) homolog, subfamily C, member 10
chr6_-_144416633 15.095 SF3B5
splicing factor 3b, subunit 5, 10kDa
chr12_-_80307690 15.093 NM_001143886
PPP1R12A
protein phosphatase 1, regulatory subunit 12A
chr2_-_10952855 15.093 NM_005742
PDIA6
protein disulfide isomerase family A, member 6
chr2_-_100046262 15.045 REV1
REV1 homolog (S. cerevisiae)
chr4_-_170679027 14.999 NM_017867
C4orf27
chromosome 4 open reading frame 27
chr11_+_57529233 14.941 NM_001085458
NM_001085459
NM_001085460
NM_001085461
NM_001085462
NM_001085463
NM_001085464
NM_001085465
NM_001085466
NM_001085467
NM_001085468
NM_001085469
NM_001206883
NM_001206884
NM_001206885
NM_001206886
NM_001206887
NM_001206888
NM_001206889
NM_001206890
NM_001206891
NM_001331
CTNND1





















catenin (cadherin-associated protein), delta 1





















chr19_-_10613767 14.896 NM_203500
KEAP1
kelch-like ECH-associated protein 1
chr9_-_14086901 14.880 NFIB
nuclear factor I/B
chr10_-_58121011 14.876 ZWINT
ZW10 interactor
chr15_-_25650647 14.843 NM_130838
UBE3A
ubiquitin protein ligase E3A
chr14_-_55658205 14.791 NM_001146015
NM_014750
DLGAP5

discs, large (Drosophila) homolog-associated protein 5

chr13_-_37573474 14.756 NM_001142364
NM_013338
ALG5

asparagine-linked glycosylation 5, dolichyl-phosphate beta-glucosyltransferase homolog (S. cerevisiae)


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.40 6.28e-29 GO:0044237 cellular metabolic process
1.35 1.26e-26 GO:0008152 metabolic process
1.49 1.09e-24 GO:0044260 cellular macromolecule metabolic process
1.45 2.22e-24 GO:0043170 macromolecule metabolic process
1.36 6.00e-24 GO:0044238 primary metabolic process
1.19 2.08e-22 GO:0009987 cellular process
1.52 4.10e-18 GO:0006807 nitrogen compound metabolic process
1.58 8.58e-18 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.52 3.15e-17 GO:0034641 cellular nitrogen compound metabolic process
1.63 4.79e-16 GO:0090304 nucleic acid metabolic process
1.61 7.42e-11 GO:0016070 RNA metabolic process
1.58 1.17e-10 GO:0010467 gene expression
1.61 1.73e-10 GO:0009059 macromolecule biosynthetic process
1.61 3.05e-10 GO:0034645 cellular macromolecule biosynthetic process
1.47 3.14e-09 GO:0048519 negative regulation of biological process
1.43 2.47e-08 GO:0044267 cellular protein metabolic process
1.46 9.21e-08 GO:0048523 negative regulation of cellular process
1.37 1.04e-07 GO:0019538 protein metabolic process
1.42 1.41e-07 GO:0044249 cellular biosynthetic process
1.41 2.69e-07 GO:0009058 biosynthetic process
1.33 4.31e-07 GO:0071840 cellular component organization or biogenesis
3.01 5.04e-07 GO:0000082 G1/S transition of mitotic cell cycle
1.38 7.82e-07 GO:0071841 cellular component organization or biogenesis at cellular level
1.86 1.12e-06 GO:0006396 RNA processing
1.65 3.28e-06 GO:0007049 cell cycle
1.92 5.01e-06 GO:0016071 mRNA metabolic process
1.31 6.61e-06 GO:0016043 cellular component organization
1.86 1.00e-05 GO:0000278 mitotic cell cycle
1.35 2.33e-05 GO:0071842 cellular component organization at cellular level
1.80 2.41e-05 GO:0051726 regulation of cell cycle
1.80 2.63e-05 GO:0009057 macromolecule catabolic process
2.10 2.86e-05 GO:0010564 regulation of cell cycle process
2.42 3.00e-05 GO:0000075 cell cycle checkpoint
2.18 3.39e-05 GO:0051329 interphase of mitotic cell cycle
2.14 6.54e-05 GO:0051325 interphase
1.85 6.78e-05 GO:0044265 cellular macromolecule catabolic process
1.66 9.56e-05 GO:0022402 cell cycle process
1.85 9.69e-05 GO:0006974 response to DNA damage stimulus
2.33 1.05e-04 GO:0071156 regulation of cell cycle arrest
1.71 1.53e-04 GO:0022403 cell cycle phase
1.63 2.42e-04 GO:0033554 cellular response to stress
1.16 3.01e-04 GO:0050794 regulation of cellular process
1.31 3.98e-04 GO:0048518 positive regulation of biological process
1.15 4.03e-04 GO:0050789 regulation of biological process
1.51 4.97e-04 GO:0010604 positive regulation of macromolecule metabolic process
1.14 6.30e-04 GO:0065007 biological regulation
1.92 6.52e-04 GO:0006397 mRNA processing
1.72 8.84e-04 GO:0006259 DNA metabolic process
1.49 9.90e-04 GO:0044248 cellular catabolic process
1.32 1.27e-03 GO:0048522 positive regulation of cellular process
1.43 1.39e-03 GO:0009056 catabolic process
2.29 1.39e-03 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
2.29 1.39e-03 GO:0000398 nuclear mRNA splicing, via spliceosome
1.53 1.70e-03 GO:0032774 RNA biosynthetic process
2.01 1.81e-03 GO:0008380 RNA splicing
2.60 2.22e-03 GO:0007093 mitotic cell cycle checkpoint
1.45 2.73e-03 GO:0009893 positive regulation of metabolic process
1.95 2.80e-03 GO:0043632 modification-dependent macromolecule catabolic process
2.23 2.84e-03 GO:0000375 RNA splicing, via transesterification reactions
1.25 3.16e-03 GO:0060255 regulation of macromolecule metabolic process
1.30 3.52e-03 GO:0006950 response to stress
1.48 3.62e-03 GO:0051246 regulation of protein metabolic process
2.04 3.73e-03 GO:0007346 regulation of mitotic cell cycle
1.44 4.14e-03 GO:0051641 cellular localization
2.18 4.91e-03 GO:0071843 cellular component biogenesis at cellular level
1.66 4.95e-03 GO:0051276 chromosome organization
1.95 5.81e-03 GO:0006412 translation
1.85 8.40e-03 GO:0030163 protein catabolic process
2.64 9.07e-03 GO:0000077 DNA damage checkpoint
1.37 9.32e-03 GO:0006996 organelle organization
1.89 1.12e-02 GO:0019941 modification-dependent protein catabolic process
1.78 1.15e-02 GO:0016032 viral reproduction
1.88 1.15e-02 GO:0051603 proteolysis involved in cellular protein catabolic process
1.97 1.23e-02 GO:0015980 energy derivation by oxidation of organic compounds
2.59 1.31e-02 GO:0000084 S phase of mitotic cell cycle
1.45 1.33e-02 GO:0051649 establishment of localization in cell
1.70 1.61e-02 GO:0034621 cellular macromolecular complex subunit organization
2.54 1.88e-02 GO:0051320 S phase
1.84 2.06e-02 GO:0044257 cellular protein catabolic process
1.42 2.07e-02 GO:0044085 cellular component biogenesis
2.13 2.22e-02 GO:0022613 ribonucleoprotein complex biogenesis
1.52 2.76e-02 GO:0046907 intracellular transport
1.42 2.79e-02 GO:0031325 positive regulation of cellular metabolic process
1.86 2.89e-02 GO:0006511 ubiquitin-dependent protein catabolic process
2.47 3.17e-02 GO:0031570 DNA integrity checkpoint
1.45 3.24e-02 GO:0032268 regulation of cellular protein metabolic process
1.31 3.25e-02 GO:0043412 macromolecule modification
1.83 3.27e-02 GO:0043434 response to peptide hormone stimulus
1.71 3.37e-02 GO:0044262 cellular carbohydrate metabolic process
1.74 4.65e-02 GO:0006091 generation of precursor metabolites and energy

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.19 5.02e-27 GO:0044424 intracellular part
1.18 6.90e-26 GO:0005622 intracellular
1.25 8.06e-24 GO:0043227 membrane-bounded organelle
1.25 8.93e-24 GO:0043231 intracellular membrane-bounded organelle
1.26 1.23e-21 GO:0005737 cytoplasm
1.37 7.64e-21 GO:0044446 intracellular organelle part
1.21 1.30e-20 GO:0043229 intracellular organelle
1.21 1.65e-20 GO:0043226 organelle
1.36 3.06e-20 GO:0044422 organelle part
1.48 1.75e-18 GO:0032991 macromolecular complex
1.64 1.46e-17 GO:0044428 nuclear part
1.59 3.48e-16 GO:0031974 membrane-enclosed lumen
1.58 1.25e-15 GO:0043233 organelle lumen
1.57 9.29e-15 GO:0070013 intracellular organelle lumen
1.64 1.76e-14 GO:0031981 nuclear lumen
1.31 1.87e-14 GO:0005634 nucleus
1.27 1.33e-12 GO:0044444 cytoplasmic part
1.70 1.16e-11 GO:0005654 nucleoplasm
1.40 5.25e-10 GO:0043234 protein complex
2.04 5.68e-09 GO:0030529 ribonucleoprotein complex
1.44 8.47e-08 GO:0005829 cytosol
1.73 3.10e-06 GO:0044451 nucleoplasm part
1.04 5.25e-04 GO:0044464 cell part
1.04 5.43e-04 GO:0005623 cell
2.49 6.45e-04 GO:0005681 spliceosomal complex
1.27 6.60e-04 GO:0043228 non-membrane-bounded organelle
1.27 6.60e-04 GO:0043232 intracellular non-membrane-bounded organelle
1.29 5.46e-03 GO:0031090 organelle membrane
1.64 6.46e-03 GO:0005730 nucleolus
1.64 1.47e-02 GO:0044427 chromosomal part
1.56 2.62e-02 GO:0005694 chromosome
10.74 3.43e-02 GO:0070552 BRISC complex

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.35 3.36e-31 GO:0005515 protein binding
1.14 7.12e-17 GO:0005488 binding
1.75 1.05e-07 GO:0003723 RNA binding
4.07 1.96e-03 GO:0043130 ubiquitin binding
3.86 4.05e-03 GO:0032182 small conjugating protein binding
1.21 2.01e-02 GO:0003676 nucleic acid binding
2.19 2.16e-02 GO:0003735 structural constituent of ribosome
2.06 3.29e-02 GO:0016758 transferase activity, transferring hexosyl groups
1.14 3.70e-02 GO:0003824 catalytic activity