Motif ID: FOXO1,3,4.p2

Z-value: 1.208


Transcription factors associated with FOXO1,3,4.p2:

Gene SymbolEntrez IDGene Name
FOXO1 2308 forkhead box O1
FOXO3 2309 forkhead box O3
FOXO4 4303 forkhead box O4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
FOXO4chrX_+_703156370.504.7e-15Click!
FOXO3chr6_+_1088821040.357.9e-08Click!
FOXO1chr13_-_412406070.221.2e-03Click!


Activity profile for motif FOXO1,3,4.p2.

activity profile for motif FOXO1,3,4.p2


Sorted Z-values histogram for motif FOXO1,3,4.p2

Sorted Z-values for motif FOXO1,3,4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOXO1,3,4.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_57044980 36.892 PPAP2B
phosphatidic acid phosphatase type 2B
chr1_-_57045235 31.880 NM_003713
PPAP2B
phosphatidic acid phosphatase type 2B
chr12_-_9268440 29.691 A2M
alpha-2-macroglobulin
chr12_-_9268522 28.439 NM_000014
A2M
alpha-2-macroglobulin
chr12_-_9268513 28.231 A2M
alpha-2-macroglobulin
chr5_-_42811959 26.021 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr1_-_57045129 25.401 PPAP2B
phosphatidic acid phosphatase type 2B
chr12_-_9268475 21.227 A2M
alpha-2-macroglobulin
chr4_-_88450601 19.344 NM_001128310
NM_004684
SPARCL1

SPARC-like 1 (hevin)

chr8_-_110655418 17.946 NM_001099756
SYBU
syntabulin (syntaxin-interacting)
chr1_-_57045214 17.602 PPAP2B
phosphatidic acid phosphatase type 2B
chr1_-_182360889 17.550 GLUL
glutamate-ammonia ligase
chr4_-_88450243 17.308 SPARCL1
SPARC-like 1 (hevin)
chr17_+_1665306 15.753 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr17_+_1665233 15.180 NM_002615
SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr22_+_33196801 14.903 NM_000362
TIMP3
TIMP metallopeptidase inhibitor 3
chr1_-_182360181 14.515 GLUL
glutamate-ammonia ligase
chr14_-_21271002 13.881 NM_002933
NM_198234
NM_198235
RNASE1


ribonuclease, RNase A family, 1 (pancreatic)


chr14_+_94577078 12.817 NM_001130080
NM_005532
IFI27

interferon, alpha-inducible protein 27

chr1_-_182360400 12.587 NM_001033056
GLUL
glutamate-ammonia ligase
chr11_+_113931228 12.571 NM_001018011
ZBTB16
zinc finger and BTB domain containing 16
chr4_+_41614911 12.491 NM_001112719
NM_001112720
LIMCH1

LIM and calponin homology domains 1

chr10_-_52645384 12.296 A1CF
APOBEC1 complementation factor
chr14_-_60097314 12.113 RTN1
reticulon 1
chr16_+_55512801 11.963 NM_004530
MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
chr1_+_226016428 11.758 EPHX1
epoxide hydrolase 1, microsomal (xenobiotic)
chr18_-_21852189 11.757 NM_018030
OSBPL1A
oxysterol binding protein-like 1A
chr6_+_121756744 11.557 NM_000165
GJA1
gap junction protein, alpha 1, 43kDa
chr17_+_1665281 11.000 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr2_-_217540722 10.997 IGFBP5
insulin-like growth factor binding protein 5
chr17_+_1665342 10.997 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr10_-_90750955 10.731 NM_001141945
ACTA2
actin, alpha 2, smooth muscle, aorta
chr1_+_204913353 10.601 NM_001160331
NFASC
neurofascin
chr14_+_74551655 10.562 NM_001024674
LIN52
lin-52 homolog (C. elegans)
chr7_-_124405029 10.537 GPR37
G protein-coupled receptor 37 (endothelin receptor type B-like)
chr20_+_44035203 10.434 NM_001048223
NM_001048224
DBNDD2

dysbindin (dystrobrevin binding protein 1) domain containing 2

chr14_-_60097223 10.334 RTN1
reticulon 1
chr5_-_149466173 10.293 CSF1R
colony stimulating factor 1 receptor
chr19_-_37019169 10.160 NM_001012756
NM_001166036
NM_001166037
NM_001166038
ZNF260



zinc finger protein 260



chr19_-_14939275 10.139 NM_017506
OR7A5
olfactory receptor, family 7, subfamily A, member 5
chr5_+_173472692 9.999 NM_015980
HMP19
HMP19 protein
chr16_+_58497628 9.984 NDRG4
NDRG family member 4
chr4_+_88896801 9.886 NM_000582
NM_001040058
NM_001040060
NM_001251829
NM_001251830
SPP1




secreted phosphoprotein 1




chr13_-_45048436 9.835 NM_001243798
TSC22D1
TSC22 domain family, member 1
chr9_+_27109138 9.751 NM_000459
TEK
TEK tyrosine kinase, endothelial
chr11_-_114466397 9.688 FAM55D
family with sequence similarity 55, member D
chr7_+_134832765 9.646 NM_018295
TMEM140
transmembrane protein 140
chr19_+_30863318 9.568 NM_014717
ZNF536
zinc finger protein 536
chr7_+_37723378 9.500


chr5_-_151066445 9.242 SPARC
secreted protein, acidic, cysteine-rich (osteonectin)
chr4_-_186697065 9.132 NM_001145673
SORBS2
sorbin and SH3 domain containing 2
chr15_+_32933869 9.078 NM_001144757
NM_003020
SCG5

secretogranin V (7B2 protein)

chr4_+_88896868 9.002 SPP1
secreted phosphoprotein 1
chr5_+_36608430 8.973 NM_001166695
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr6_-_46889620 8.946 NM_001098518
GPR116
G protein-coupled receptor 116
chr8_-_134309448 8.913 NM_001135242
NM_006096
NDRG1

N-myc downstream regulated 1

chr4_+_88896899 8.878 SPP1
secreted phosphoprotein 1
chr1_-_201465700 8.877 NM_001193572
CSRP1
cysteine and glycine-rich protein 1
chr22_-_19512859 8.856 NM_001130861
NM_003277
CLDN5

claudin 5

chr17_+_3377346 8.794 NM_001128085
ASPA
aspartoacylase
chr14_-_81687265 8.736 NM_015859
GTF2A1
general transcription factor IIA, 1, 19/37kDa
chr16_-_11375094 8.671 NM_002761
PRM1
protamine 1
chr17_-_40021616 8.610 NM_018143
KLHL11
kelch-like 11 (Drosophila)
chr6_-_152623213 8.604 SYNE1
spectrin repeat containing, nuclear envelope 1
chr4_+_88896838 8.596 SPP1
secreted phosphoprotein 1
chr14_-_74551073 8.524 ALDH6A1
aldehyde dehydrogenase 6 family, member A1
chr4_+_113739203 8.346 NM_001127493
ANK2
ankyrin 2, neuronal
chr1_-_163172863 8.228 NM_003617
RGS5
regulator of G-protein signaling 5
chr8_-_27941387 8.153 NM_001010906
C8orf80
chromosome 8 open reading frame 80
chr11_-_62476976 8.015 BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr14_-_74551159 7.978 NM_005589
ALDH6A1
aldehyde dehydrogenase 6 family, member A1
chr5_+_161275897 7.926 NM_001127646
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr1_+_162039469 7.925 NM_001164757
NM_014697
NOS1AP

nitric oxide synthase 1 (neuronal) adaptor protein

chr2_-_224467095 7.903 SCG2
secretogranin II
chr12_+_79439432 7.885 NM_001135806
SYT1
synaptotagmin I
chr6_-_31514620 7.881 NM_001204078
NM_130463
NM_138282
ATP6V1G2


ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2


chr18_-_74728963 7.686 MBP
myelin basic protein
chr16_+_77233348 7.665 NM_001129979
SYCE1L
synaptonemal complex central element protein 1-like
chr16_+_58497548 7.636 NM_020465
NDRG4
NDRG family member 4
chr2_-_71454200 7.541 NM_020459
PAIP2B
poly(A) binding protein interacting protein 2B
chrX_-_100914816 7.494 NM_014782
NM_177949
ARMCX2

armadillo repeat containing, X-linked 2

chr16_-_4322695 7.451 TFAP4
transcription factor AP-4 (activating enhancer binding protein 4)
chr10_+_123754141 7.266 TACC2
transforming, acidic coiled-coil containing protein 2
chr2_+_233498206 7.257 NM_025202
EFHD1
EF-hand domain family, member D1
chr5_-_149466126 7.257 CSF1R
colony stimulating factor 1 receptor
chr19_-_36523540 7.231 NM_001199570
CLIP3
CAP-GLY domain containing linker protein 3
chr21_+_41239346 7.152 NM_006198
PCP4
Purkinje cell protein 4
chr2_-_224467049 7.119 SCG2
secretogranin II
chr9_+_706744 6.874 NM_153186
KANK1
KN motif and ankyrin repeat domains 1
chr4_+_154074269 6.851 NM_001130067
TRIM2
tripartite motif containing 2
chr11_-_5526833 6.804 NM_001005567
OR51B5
HBE1
olfactory receptor, family 51, subfamily B, member 5
hemoglobin, epsilon 1
chr19_+_859673 6.787 CFD
complement factor D (adipsin)
chr12_+_51318515 6.778 NM_014033
METTL7A
methyltransferase like 7A
chr12_+_51318743 6.777 METTL7A
methyltransferase like 7A
chr15_+_43985083 6.732 NM_001015001
CKMT1A
creatine kinase, mitochondrial 1A
chr2_-_224467142 6.673 NM_003469
SCG2
secretogranin II
chr12_+_53491417 6.586 NM_002178
IGFBP6
insulin-like growth factor binding protein 6
chr9_+_124043719 6.559 GSN
gelsolin
chr3_+_133495925 6.535 TF
transferrin
chr3_+_186560462 6.512 NM_001177800
NM_004797
ADIPOQ

adiponectin, C1Q and collagen domain containing

chr11_-_114466471 6.509 NM_001077639
NM_017678
FAM55D

family with sequence similarity 55, member D

chr11_+_73661363 6.501 NM_153614
DNAJB13
DnaJ (Hsp40) homolog, subfamily B, member 13
chr4_+_55095263 6.478 NM_006206
PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr3_-_28390506 6.472 NM_001134432
NM_001134433
NM_022461
AZI2


5-azacytidine induced 2


chr18_-_74729049 6.435 NM_001025081
NM_001025090
NM_001025092
NM_002385
MBP



myelin basic protein



chr11_-_66675334 6.399 NM_022172
PC
pyruvate carboxylase
chr12_-_10251520 6.359 NM_016511
CLEC1A
C-type lectin domain family 1, member A
chr1_-_27998658 6.323 IFI6
interferon, alpha-inducible protein 6
chr1_-_27998719 6.260 NM_002038
NM_022872
NM_022873
IFI6


interferon, alpha-inducible protein 6


chr10_-_118680978 6.217 KIAA1598
KIAA1598
chr16_+_58534045 6.208 NM_001242833
NM_001242834
NM_001242835
NM_001242836
NDRG4



NDRG family member 4



chr1_+_43855599 6.207 SZT2
seizure threshold 2 homolog (mouse)
chr7_-_143059696 6.197 NM_001031690
FAM131B
family with sequence similarity 131, member B
chr18_-_500583 6.138 NM_130386
COLEC12
collectin sub-family member 12
chr11_-_46638708 6.111 NM_173811
HARBI1
harbinger transposase derived 1
chr11_-_8739398 6.096 ST5
suppression of tumorigenicity 5
chr4_-_174320616 6.083 NM_007281
SCRG1
stimulator of chondrogenesis 1
chr12_+_53491448 6.079 IGFBP6
insulin-like growth factor binding protein 6
chr14_+_70918873 6.052 NM_003813
ADAM21
ADAM metallopeptidase domain 21
chr2_-_217560247 6.023 NM_000599
IGFBP5
insulin-like growth factor binding protein 5
chr3_+_38347426 5.995 NM_004803
SLC22A14
solute carrier family 22, member 14
chr5_-_149535138 5.975 PDGFRB
platelet-derived growth factor receptor, beta polypeptide
chr1_+_163041694 5.970 NM_001113380
RGS4
regulator of G-protein signaling 4
chr11_+_112831968 5.970 NM_000615
NM_001076682
NM_001242607
NM_001242608
NM_181351
NCAM1




neural cell adhesion molecule 1




chr3_-_185826748 5.939 NM_004454
ETV5
ets variant 5
chr17_+_3379295 5.910 NM_000049
ASPA
aspartoacylase
chr1_+_92632608 5.897 NM_015237
KIAA1107
KIAA1107
chr19_+_859658 5.883 NM_001928
CFD
complement factor D (adipsin)
chr17_+_77751929 5.842 NM_005189
NM_032647
CBX2

chromobox homolog 2

chr15_+_43885251 5.814 NM_020990
CKMT1B
CKMT1A
creatine kinase, mitochondrial 1B
creatine kinase, mitochondrial 1A
chr7_+_20655244 5.774 NM_001163941
ABCB5
ATP-binding cassette, sub-family B (MDR/TAP), member 5
chr4_-_70826712 5.744 NM_001891
CSN2
casein beta
chr19_+_15160194 5.725 NM_012114
CASP14
caspase 14, apoptosis-related cysteine peptidase
chr2_-_238322840 5.663 NM_004369
NM_057164
NM_057165
NM_057166
NM_057167
COL6A3




collagen, type VI, alpha 3




chr22_-_25777543 5.659 NM_001135772
LRP5L
low density lipoprotein receptor-related protein 5-like
chr5_-_149466094 5.657 CSF1R
colony stimulating factor 1 receptor
chr10_+_111985628 5.632 NM_005962
MXI1
MAX interactor 1
chr4_+_88754120 5.588 NM_001184695
NM_001184696
NM_001184697
NM_020203
MEPE



matrix extracellular phosphoglycoprotein



chr1_-_203154304 5.555 CHI3L1
chitinase 3-like 1 (cartilage glycoprotein-39)
chr8_+_133879202 5.549 NM_003235
TG
thyroglobulin
chr1_-_170038055 5.509 NM_001204517
KIFAP3
kinesin-associated protein 3
chr2_-_183731279 5.500 NM_001463
FRZB
frizzled-related protein
chr7_-_83270746 5.499 NM_001178129
SEMA3E
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
chr4_+_124320664 5.468 NM_005841
SPRY1
sprouty homolog 1, antagonist of FGF signaling (Drosophila)
chr5_+_140771482 5.457 NM_014004
NM_032088
PCDHGA8

protocadherin gamma subfamily A, 8

chr19_-_40732563 5.450 NM_024877
CNTD2
cyclin N-terminal domain containing 2
chr14_-_21493858 5.418 NDRG2
NDRG family member 2
chr8_-_56685869 5.399 NM_152417
TMEM68
transmembrane protein 68
chr2_+_189839113 5.393 COL3A1
collagen, type III, alpha 1
chrX_+_18709044 5.337 NM_006240
NM_152224
NM_152226
PPEF1


protein phosphatase, EF-hand calcium binding domain 1


chr1_-_27998700 5.327 IFI6
interferon, alpha-inducible protein 6
chr6_-_41715078 5.285 NM_001166424
NM_002630
PGC

progastricsin (pepsinogen C)

chr19_+_50031232 5.276 RCN3
reticulocalbin 3, EF-hand calcium binding domain
chr15_+_42696957 5.275 NM_173089
NM_173090
CAPN3

calpain 3, (p94)

chr19_-_36523770 5.266 NM_015526
CLIP3
CAP-GLY domain containing linker protein 3
chrX_+_70315637 5.236 NM_001170931
NM_005938
FOXO4

forkhead box O4

chr7_-_95225802 5.232 NM_002612
PDK4
pyruvate dehydrogenase kinase, isozyme 4
chr19_-_51531283 5.153 NM_001167605
NM_006853
KLK11

kallikrein-related peptidase 11

chr7_+_106505876 5.139 NM_002649
PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr1_-_54518790 5.133 TMEM59
transmembrane protein 59
chr6_+_101846860 5.118 NM_001166247
NM_021956
NM_175768
GRIK2


glutamate receptor, ionotropic, kainate 2


chr11_+_57365026 5.114 NM_000062
SERPING1
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
chr3_+_138066489 5.021 NM_001252091
NM_012219
MRAS

muscle RAS oncogene homolog

chr1_-_54518886 5.019 TMEM59
transmembrane protein 59
chr1_+_43855549 4.990 NM_015284
SZT2
seizure threshold 2 homolog (mouse)
chr15_+_44580870 4.984 NM_138423
NM_177974
CASC4

cancer susceptibility candidate 4

chrX_+_83116153 4.983 NM_021118
CYLC1
cylicin, basic protein of sperm head cytoskeleton 1
chr16_+_56225301 4.980 GNAO1
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
chr2_+_175260455 4.918 NM_001193528
NM_024583
SCRN3

secernin 3

chr2_+_207406815 4.916 ADAM23
ADAM metallopeptidase domain 23
chr14_+_35514112 4.854 NM_001079519
FAM177A1
family with sequence similarity 177, member A1
chr18_-_40695483 4.852 NM_002930
RIT2
Ras-like without CAAX 2
chr10_-_75335415 4.839 NM_152586
USP54
ubiquitin specific peptidase 54
chr7_-_31380507 4.838 NM_022728
NEUROD6
neurogenic differentiation 6
chr1_-_57431620 4.831 NM_000066
C8B
complement component 8, beta polypeptide
chr3_+_50712671 4.817 NM_004947
DOCK3
dedicator of cytokinesis 3
chr14_-_76447445 4.802 TGFB3
transforming growth factor, beta 3
chr5_-_149535420 4.796 NM_002609
PDGFRB
platelet-derived growth factor receptor, beta polypeptide
chr20_-_43150686 4.772 NM_006811
NM_198941
SERINC3

serine incorporator 3

chr11_+_46638783 4.770 NM_001142673
NM_001205119
NM_001205120
NM_001205121
NM_001205122
NM_014741
ATG13





ATG13 autophagy related 13 homolog (S. cerevisiae)





chr1_-_7973286 4.765 UTS2
urotensin 2
chr2_+_189839078 4.763 NM_000090
COL3A1
collagen, type III, alpha 1
chr2_+_220042986 4.760 FAM134A
family with sequence similarity 134, member A
chr4_-_155312448 4.758 NM_017639
DCHS2
dachsous 2 (Drosophila)
chr5_-_141338626 4.738 NM_016580
PCDH12
protocadherin 12
chr2_+_32502971 4.729 YIPF4
Yip1 domain family, member 4
chr4_-_48014960 4.727 NM_000087
CNGA1
cyclic nucleotide gated channel alpha 1
chr5_+_79703792 4.721 NM_001105251
NM_014733
ZFYVE16

zinc finger, FYVE domain containing 16

chr3_+_39509069 4.691 NM_182935
MOBP
myelin-associated oligodendrocyte basic protein
chr6_-_111136616 4.667 CDK19
cyclin-dependent kinase 19
chr1_-_168106535 4.656 GPR161
G protein-coupled receptor 161
chr5_-_10307873 4.655 CMBL
carboxymethylenebutenolidase homolog (Pseudomonas)
chr18_+_72922725 4.605 NM_005786
TSHZ1
teashirt zinc finger homeobox 1
chr3_+_186560478 4.589 ADIPOQ
adiponectin, C1Q and collagen domain containing
chr12_+_21679190 4.575 NM_030572
C12orf39
chromosome 12 open reading frame 39
chr20_-_43150673 4.567 SERINC3
serine incorporator 3
chr2_+_202047803 4.563 CASP10
caspase 10, apoptosis-related cysteine peptidase
chr2_-_211018294 4.559 C2orf67
chromosome 2 open reading frame 67
chr1_-_54518915 4.555 TMEM59
transmembrane protein 59
chr16_+_55515468 4.510 NM_001127891
MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.29 8.25e-07 GO:0032501 multicellular organismal process
1.13 2.32e-06 GO:0009987 cellular process
1.35 3.94e-06 GO:0023052 signaling
1.42 2.44e-04 GO:0042221 response to chemical stimulus
1.31 1.01e-03 GO:0007165 signal transduction
1.40 1.80e-03 GO:0048869 cellular developmental process
1.19 4.21e-03 GO:0050896 response to stimulus
1.30 6.17e-03 GO:0048856 anatomical structure development
1.26 7.25e-03 GO:0032502 developmental process
1.58 9.57e-03 GO:0009605 response to external stimulus
1.38 9.59e-03 GO:0030154 cell differentiation
3.85 1.12e-02 GO:0045444 fat cell differentiation
1.45 1.39e-02 GO:0009653 anatomical structure morphogenesis
1.24 1.51e-02 GO:0051716 cellular response to stimulus
1.61 1.56e-02 GO:0040011 locomotion
1.26 2.62e-02 GO:0007275 multicellular organismal development
1.14 3.10e-02 GO:0065007 biological regulation
2.45 3.14e-02 GO:0006936 muscle contraction
1.29 3.37e-02 GO:0048731 system development
1.37 3.48e-02 GO:0048583 regulation of response to stimulus

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.47 1.33e-06 GO:0044459 plasma membrane part
1.56 8.70e-05 GO:0005887 integral to plasma membrane
1.55 1.41e-04 GO:0031226 intrinsic to plasma membrane
1.39 4.20e-04 GO:0005576 extracellular region
1.56 1.10e-03 GO:0044421 extracellular region part
1.60 4.68e-03 GO:0005615 extracellular space
2.08 4.99e-02 GO:0030141 stored secretory granule

Nothing significant found in function category.