Motif ID: HES1.p2

Z-value: 2.018


Transcription factors associated with HES1.p2:

Gene SymbolEntrez IDGene Name
HES1 3280 hairy and enhancer of split 1, (Drosophila)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HES1chr3_+_193853937-0.195.9e-03Click!


Activity profile for motif HES1.p2.

activity profile for motif HES1.p2


Sorted Z-values histogram for motif HES1.p2

Sorted Z-values for motif HES1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HES1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_10588451 33.060 NM_002539
ODC1
ornithine decarboxylase 1
chr9_+_91926109 32.218 NM_001827
CKS2
CDC28 protein kinase regulatory subunit 2
chr1_-_94374986 30.923 NM_002061
GCLM
glutamate-cysteine ligase, modifier subunit
chr9_+_131451519 29.113 SET
SET nuclear oncogene
chr1_+_165797060 28.561 UCK2
uridine-cytidine kinase 2
chr1_-_94375028 27.267 GCLM
glutamate-cysteine ligase, modifier subunit
chr1_+_165796652 25.749 NM_012474
UCK2
uridine-cytidine kinase 2
chr6_-_13814546 25.679 NM_001031713
CCDC90A
coiled-coil domain containing 90A
chr1_-_94374949 24.873 GCLM
glutamate-cysteine ligase, modifier subunit
chr12_+_131356640 24.866 RAN
RAN, member RAS oncogene family
chr12_-_123380608 24.776


chr16_+_29817810 24.685 NM_001042539
NM_002383
MAZ

MYC-associated zinc finger protein (purine-binding transcription factor)

chr5_-_133340823 23.187 NM_003374
VDAC1
voltage-dependent anion channel 1
chr1_-_11120081 23.164 NM_003132
SRM
spermidine synthase
chrX_+_21958714 22.525 NM_004595
SMS
spermine synthase
chr2_+_113403433 20.918 NM_005415
SLC20A1
solute carrier family 20 (phosphate transporter), member 1
chr7_+_155089614 20.917 INSIG1
insulin induced gene 1
chr17_+_73257992 20.695 MRPS7
mitochondrial ribosomal protein S7
chr3_+_184081178 20.326 NM_006232
POLR2H
polymerase (RNA) II (DNA directed) polypeptide H
chr17_+_73257944 20.207 MRPS7
mitochondrial ribosomal protein S7
chr22_+_20105076 19.340 RANBP1
RAN binding protein 1
chr17_+_73257745 19.127 NM_015971
MRPS7
mitochondrial ribosomal protein S7
chr14_+_105886146 19.098 NM_001203258
NM_004689
MTA1

metastasis associated 1

chr1_+_220267491 19.035 IARS2
isoleucyl-tRNA synthetase 2, mitochondrial
chr2_-_136633934 18.987 MCM6
minichromosome maintenance complex component 6
chr18_+_12948010 18.895 SEH1L
SEH1-like (S. cerevisiae)
chr9_+_131451470 18.743 NM_003011
SET
SET nuclear oncogene
chr7_+_155089483 18.646 NM_005542
NM_198336
NM_198337
INSIG1


insulin induced gene 1


chr2_+_216176808 18.549 ATIC
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
chr4_-_24586015 18.336 DHX15
DEAH (Asp-Glu-Ala-His) box polypeptide 15
chr20_+_35234210 18.312 C20orf24
chromosome 20 open reading frame 24
chr2_-_136634002 18.184 NM_005915
MCM6
minichromosome maintenance complex component 6
chr17_+_45727274 18.014 NM_002265
KPNB1
karyopherin (importin) beta 1
chr1_-_156721501 17.921 NM_004494
HDGF
hepatoma-derived growth factor
chr19_+_33072087 17.805 NM_004708
PDCD5
programmed cell death 5
chr2_+_181845605 17.233 UBE2E3
ubiquitin-conjugating enzyme E2E 3
chr11_-_14665162 16.931 NM_148976
PSMA1
proteasome (prosome, macropain) subunit, alpha type, 1
chr9_+_131451847 16.196 SET
SET nuclear oncogene
chr13_-_99229037 16.070 STK24
serine/threonine kinase 24
chr13_+_27998614 15.925 NM_002097
GTF3A
general transcription factor IIIA
chr19_-_55918980 15.779 UBE2S
ubiquitin-conjugating enzyme E2S
chrX_-_16887974 15.534 NM_001198719
RBBP7
retinoblastoma binding protein 7
chr2_+_181845088 15.439 NM_182678
NM_006357
UBE2E3

ubiquitin-conjugating enzyme E2E 3

chr12_+_69979447 15.164 NM_001198842
CCT2
chaperonin containing TCP1, subunit 2 (beta)
chr17_-_73150493 14.953 HN1
hematological and neurological expressed 1
chrX_-_16888442 14.671 RBBP7
retinoblastoma binding protein 7
chr3_+_23847349 14.652 NM_003341
NM_182666
UBE2E1

ubiquitin-conjugating enzyme E2E 1

chr22_+_20105145 14.524 RANBP1
RAN binding protein 1
chr16_-_47007567 14.433 NM_005880
DNAJA2
DnaJ (Hsp40) homolog, subfamily A, member 2
chr8_+_145149978 14.303 CYC1
cytochrome c-1
chr11_+_747428 14.249 NM_006755
TALDO1
transaldolase 1
chr22_+_20105095 14.200 RANBP1
RAN binding protein 1
chr17_+_35849950 14.183 NM_007026
DUSP14
dual specificity phosphatase 14
chr6_+_34204928 14.143 HMGA1
high mobility group AT-hook 1
chr19_-_13068033 13.935 NM_052850
GADD45GIP1
growth arrest and DNA-damage-inducible, gamma interacting protein 1
chr16_-_85832900 13.899 NM_001142288
NM_006067
COX4NB

COX4 neighbor

chr1_+_220267418 13.873 NM_018060
IARS2
isoleucyl-tRNA synthetase 2, mitochondrial
chr19_-_13068008 13.869 GADD45GIP1
growth arrest and DNA-damage-inducible, gamma interacting protein 1
chr8_+_145149936 13.823 NM_001916
CYC1
cytochrome c-1
chr8_+_26149004 13.716 NM_002717
PPP2R2A
protein phosphatase 2, regulatory subunit B, alpha
chr2_+_181845803 13.629 UBE2E3
ubiquitin-conjugating enzyme E2E 3
chr1_+_23345928 13.600 NM_001009999
NM_015013
KDM1A

lysine (K)-specific demethylase 1A

chr1_-_53793743 13.569 NM_001018054
NM_004631
NM_017522
NM_033300
LRP8



low density lipoprotein receptor-related protein 8, apolipoprotein e receptor



chr6_+_34204690 13.503 HMGA1
high mobility group AT-hook 1
chr1_-_11120047 13.487 SRM
spermidine synthase
chr20_+_35234152 13.383 C20orf24
chromosome 20 open reading frame 24
chrX_-_16888462 13.347 NM_002893
RBBP7
retinoblastoma binding protein 7
chr11_+_747424 13.333 TALDO1
transaldolase 1
chr13_-_99229226 13.311 NM_001032296
STK24
serine/threonine kinase 24
chr20_+_57556322 13.240 TH1L
TH1-like (Drosophila)
chr6_+_57037333 13.209 BAG2
BCL2-associated athanogene 2
chr8_+_97274106 13.200 PTDSS1
phosphatidylserine synthase 1
chr6_+_10747991 13.187 NM_001127711
NM_030969
TMEM14B

transmembrane protein 14B

chr1_+_23345985 13.073 KDM1A
lysine (K)-specific demethylase 1A
chr17_+_45608738 12.900 NPEPPS
aminopeptidase puromycin sensitive
chr22_+_39898365 12.570 SMCR7L
Smith-Magenis syndrome chromosome region, candidate 7-like
chr8_-_97273795 12.545 NM_015942
MTERFD1
MTERF domain containing 1
chr1_+_29063443 12.543 NM_001172828
YTHDF2
YTH domain family, member 2
chr19_+_984316 12.526 NM_024100
WDR18
WD repeat domain 18
chr11_-_93474507 12.509 NM_024116
TAF1D
TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
chr20_+_35234077 12.345 NM_001199534
NM_018840
NM_199483
C20orf24


chromosome 20 open reading frame 24


chr7_+_98923495 12.295 NM_001190996
NM_006409
ARPC1A

actin related protein 2/3 complex, subunit 1A, 41kDa

chr1_+_29063132 12.261 NM_001173128
NM_016258
YTHDF2

YTH domain family, member 2

chr17_+_66031885 12.258 KPNA2
karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
chr4_+_57302268 12.247 NM_001079524
NM_001079525
PAICS

phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase

chr4_-_24586145 12.203 DHX15
DEAH (Asp-Glu-Ala-His) box polypeptide 15
chr20_+_31407696 12.162 NM_012325
MAPRE1
microtubule-associated protein, RP/EB family, member 1
chrX_-_109561314 12.122 NM_001025580
NM_015365
AMMECR1

Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1

chr11_+_1968586 12.084 MRPL23
mitochondrial ribosomal protein L23
chr7_-_91763775 12.067 CYP51A1
cytochrome P450, family 51, subfamily A, polypeptide 1
chr2_-_10588273 12.031 ODC1
ornithine decarboxylase 1
chr12_+_131356617 12.005 RAN
RAN, member RAS oncogene family
chr7_-_87849341 12.000 SRI
sorcin
chr19_-_1652327 11.940 NM_003200
TCF3
transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)
chr5_-_133340380 11.935 VDAC1
voltage-dependent anion channel 1
chr2_-_198364522 11.922 HSPD1
heat shock 60kDa protein 1 (chaperonin)
chr5_-_133340358 11.915 VDAC1
voltage-dependent anion channel 1
chr8_+_26149043 11.845 PPP2R2A
protein phosphatase 2, regulatory subunit B, alpha
chr1_-_32801606 11.538 NM_023009
MARCKSL1
MARCKS-like 1
chr7_-_148581379 11.530 EZH2
enhancer of zeste homolog 2 (Drosophila)
chr3_-_33481877 11.519 NM_001128161
UBP1
upstream binding protein 1 (LBP-1a)
chr1_+_154947166 11.480 CKS1B
CDC28 protein kinase regulatory subunit 1B
chr5_-_133340389 11.415 VDAC1
voltage-dependent anion channel 1
chr3_-_33481862 11.321 NM_001128160
NM_014517
UBP1

upstream binding protein 1 (LBP-1a)

chr22_+_20105068 11.317 RANBP1
RAN binding protein 1
chr13_-_99229117 11.274 STK24
serine/threonine kinase 24
chr20_+_11871364 11.244 NM_181443
BTBD3
BTB (POZ) domain containing 3
chr21_+_33031932 11.220 NM_000454
SOD1
superoxide dismutase 1, soluble
chr2_+_187351032 11.195 ZC3H15
zinc finger CCCH-type containing 15
chr19_-_18433847 11.179 LSM4
LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr7_-_148581403 11.178 NM_001203247
NM_001203248
NM_004456
NM_152998
EZH2



enhancer of zeste homolog 2 (Drosophila)



chr16_-_87903028 11.153 NM_003486
SLC7A5
solute carrier family 7 (amino acid transporter light chain, L system), member 5
chr1_+_43148359 11.048 YBX1
Y box binding protein 1
chr7_-_148581297 11.037 EZH2
enhancer of zeste homolog 2 (Drosophila)
chr7_-_148581377 11.035 EZH2
enhancer of zeste homolog 2 (Drosophila)
chr4_-_71705188 10.990 NM_001098477
GRSF1
G-rich RNA sequence binding factor 1
chr7_-_102985068 10.903 NM_001129887
NM_014377
DNAJC2

DnaJ (Hsp40) homolog, subfamily C, member 2

chr1_+_154947147 10.902 CKS1B
CDC28 protein kinase regulatory subunit 1B
chr12_-_46766019 10.899 SLC38A2
solute carrier family 38, member 2
chr12_-_46662779 10.854 SLC38A1
solute carrier family 38, member 1
chr2_-_198364560 10.848 HSPD1
heat shock 60kDa protein 1 (chaperonin)
chr9_+_116037913 10.798 NM_001244926
NM_004697
PRPF4

PRP4 pre-mRNA processing factor 4 homolog (yeast)

chr1_+_94883929 10.770 NM_001122674
NM_002858
ABCD3

ATP-binding cassette, sub-family D (ALD), member 3

chr1_-_156722023 10.577 NM_001126051
NM_001126050
HDGF

hepatoma-derived growth factor

chr21_-_40720938 10.571 HMGN1
high mobility group nucleosome binding domain 1
chr7_-_10979752 10.570 NM_002489
NDUFA4
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9kDa
chr5_-_31532164 10.553 NM_001100412
NM_013235
DROSHA

drosha, ribonuclease type III

chr2_+_187350870 10.547 NM_018471
ZC3H15
zinc finger CCCH-type containing 15
chr21_-_18985104 10.506 BTG3
BTG family, member 3
chr11_+_1968499 10.492 NM_021134
MRPL23
mitochondrial ribosomal protein L23
chr17_+_34842472 10.481 NM_004773
ZNHIT3
zinc finger, HIT-type containing 3
chr12_-_46662709 10.476 SLC38A1
solute carrier family 38, member 1
chr19_-_18433933 10.415 NM_001252129
NM_012321
LSM4

LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)

chr16_+_81040515 10.376 CENPN
centromere protein N
chr2_+_181845368 10.360 UBE2E3
ubiquitin-conjugating enzyme E2E 3
chr19_-_14530155 10.301 NM_005804
DDX39A
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
chr21_-_18985224 10.279 NM_001130914
NM_006806
BTG3

BTG family, member 3

chr14_-_89883306 10.223 NM_005197
FOXN3
forkhead box N3
chr21_-_18985189 10.218 BTG3
BTG family, member 3
chr19_-_10613767 10.187 NM_203500
KEAP1
kelch-like ECH-associated protein 1
chr1_+_154947116 10.135 NM_001826
CKS1B
CDC28 protein kinase regulatory subunit 1B
chr6_+_34204647 10.107 NM_145901
NM_145902
HMGA1

high mobility group AT-hook 1

chr22_+_32340592 10.070 YWHAH
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide
chr2_-_152684689 10.020 ARL5A
ADP-ribosylation factor-like 5A
chr12_-_46663207 9.973 NM_001077484
NM_030674
SLC38A1

solute carrier family 38, member 1

chr4_-_24586178 9.966 NM_001358
DHX15
DEAH (Asp-Glu-Ala-His) box polypeptide 15
chr12_-_49525271 9.962 NM_006082
TUBA1B
tubulin, alpha 1b
chr17_+_35849997 9.952 DUSP14
dual specificity phosphatase 14
chr5_+_170814707 9.937 NM_001037738
NM_002520
NM_199185
NPM1


nucleophosmin (nucleolar phosphoprotein B23, numatrin)


chr19_+_8509869 9.919 HNRNPM
heterogeneous nuclear ribonucleoprotein M
chr20_+_47662782 9.896 NM_001316
CSE1L
CSE1 chromosome segregation 1-like (yeast)
chr7_+_87505543 9.888 NM_006716
DBF4
DBF4 homolog (S. cerevisiae)
chr7_-_99698278 9.851 NM_182776
MCM7
minichromosome maintenance complex component 7
chr4_+_57301898 9.844 NM_006452
PAICS
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
chr7_-_10979683 9.831 NDUFA4
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9kDa
chr21_-_40721010 9.824 NM_004965
HMGN1
high mobility group nucleosome binding domain 1
chr17_+_26646120 9.766 NM_014573
TMEM97
transmembrane protein 97
chr1_+_214454276 9.733 NM_020197
SMYD2
SET and MYND domain containing 2
chrX_-_16888175 9.729 RBBP7
retinoblastoma binding protein 7
chr8_+_87526646 9.727 NM_003909
CPNE3
copine III
chr21_-_30445949 9.722 CCT8
chaperonin containing TCP1, subunit 8 (theta)
chr19_+_10982369 9.721 CARM1
coactivator-associated arginine methyltransferase 1
chr1_+_43824598 9.664 NM_001255
CDC20
cell division cycle 20 homolog (S. cerevisiae)
chr12_+_104609501 9.664 NM_001093771
TXNRD1
thioredoxin reductase 1
chr16_+_57481336 9.599 NM_020312
COQ9
coenzyme Q9 homolog (S. cerevisiae)
chr12_+_131356557 9.574 NM_006325
RAN
RAN, member RAS oncogene family
chr21_-_30445913 9.547 CCT8
chaperonin containing TCP1, subunit 8 (theta)
chr1_+_41445402 9.541 CTPS
CTP synthase
chr12_-_122712019 9.539 NM_019887
NM_138929
DIABLO

diablo, IAP-binding mitochondrial protein

chr6_-_17706617 9.528 NM_005124
NUP153
nucleoporin 153kDa
chr17_+_7476023 9.509 NM_001204510
NM_001416
EIF4A1

eukaryotic translation initiation factor 4A1

chr21_-_40555342 9.501 NM_003720
NM_203433
PSMG1

proteasome (prosome, macropain) assembly chaperone 1

chr17_-_57184034 9.490 TRIM37
tripartite motif containing 37
chr7_+_75677356 9.403 NM_005918
MDH2
malate dehydrogenase 2, NAD (mitochondrial)
chr5_-_79950783 9.376 NM_000791
DHFR
dihydrofolate reductase
chr16_-_47007483 9.275 DNAJA2
DnaJ (Hsp40) homolog, subfamily A, member 2
chr19_+_10982244 9.163 NM_199141
CARM1
coactivator-associated arginine methyltransferase 1
chr11_-_2950593 9.152 NM_003311
PHLDA2
pleckstrin homology-like domain, family A, member 2
chr7_+_100303673 9.136 NM_005837
POP7
processing of precursor 7, ribonuclease P/MRP subunit (S. cerevisiae)
chr13_+_76123885 9.126 NM_006002
UCHL3
ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
chr17_-_57184174 9.121 NM_001005207
NM_015294
TRIM37

tripartite motif containing 37

chr5_-_68665316 9.097 NM_003187
NM_016283
TAF9

TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa

chr22_+_32340435 8.995 NM_003405
YWHAH
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide
chrX_-_109561298 8.953 AMMECR1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr12_+_3068442 8.936 NM_003213
NM_201441
NM_201443
TEAD4


TEA domain family member 4


chr8_-_102217519 8.936 ZNF706
zinc finger protein 706
chr4_-_185655215 8.915 NM_024629
MLF1IP
MLF1 interacting protein
chr2_-_240964717 8.905 NDUFA10
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa
chr15_-_77363451 8.899 TSPAN3
tetraspanin 3
chr7_+_56119377 8.881 NM_001009186
NM_001762
CCT6A

chaperonin containing TCP1, subunit 6A (zeta 1)

chr5_+_170814952 8.832 NPM1
nucleophosmin (nucleolar phosphoprotein B23, numatrin)
chrX_+_23685613 8.810 PRDX4
peroxiredoxin 4
chr11_-_47447457 8.785 PSMC3
proteasome (prosome, macropain) 26S subunit, ATPase, 3
chr3_-_186524483 8.754 NM_181573
RFC4
replication factor C (activator 1) 4, 37kDa
chr2_+_85766291 8.716 MAT2A
methionine adenosyltransferase II, alpha
chr17_-_40075153 8.683 ACLY
ATP citrate lyase
chr4_-_84205897 8.621 COQ2
coenzyme Q2 homolog, prenyltransferase (yeast)
chr12_+_49658862 8.606 NM_032704
TUBA1C
tubulin, alpha 1c
chr7_+_16685757 8.604 NM_001159767
NM_014038
BZW2

basic leucine zipper and W2 domains 2

chr3_-_47823386 8.567 NM_003074
SMARCC1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.55 1.75e-60 GO:0044237 cellular metabolic process
1.45 1.21e-51 GO:0008152 metabolic process
1.49 1.09e-49 GO:0044238 primary metabolic process
1.25 1.23e-45 GO:0009987 cellular process
1.74 7.10e-42 GO:0006807 nitrogen compound metabolic process
1.60 1.09e-41 GO:0044260 cellular macromolecule metabolic process
1.74 1.04e-40 GO:0034641 cellular nitrogen compound metabolic process
1.80 4.11e-39 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.51 2.19e-36 GO:0043170 macromolecule metabolic process
1.78 6.57e-28 GO:0090304 nucleic acid metabolic process
1.71 8.15e-26 GO:0044249 cellular biosynthetic process
1.68 2.93e-25 GO:0009058 biosynthetic process
1.60 1.32e-19 GO:0044267 cellular protein metabolic process
1.70 3.69e-18 GO:0010467 gene expression
1.72 8.65e-18 GO:0016070 RNA metabolic process
1.49 5.67e-16 GO:0019538 protein metabolic process
1.51 1.57e-15 GO:0071841 cellular component organization or biogenesis at cellular level
1.68 1.79e-15 GO:0009059 macromolecule biosynthetic process
1.44 1.84e-15 GO:0071840 cellular component organization or biogenesis
1.91 3.09e-15 GO:0007049 cell cycle
2.17 6.52e-15 GO:0006396 RNA processing
1.67 1.04e-14 GO:0034645 cellular macromolecule biosynthetic process
2.20 5.28e-14 GO:0000278 mitotic cell cycle
1.42 2.00e-13 GO:0016043 cellular component organization
1.65 4.04e-13 GO:0006996 organelle organization
1.48 5.00e-13 GO:0071842 cellular component organization at cellular level
2.05 7.42e-13 GO:0022403 cell cycle phase
1.93 2.67e-12 GO:0022402 cell cycle process
2.09 1.09e-11 GO:0006259 DNA metabolic process
1.92 1.65e-11 GO:0046907 intracellular transport
1.56 4.80e-11 GO:0044281 small molecule metabolic process
2.49 1.35e-10 GO:0051325 interphase
2.50 1.58e-10 GO:0051329 interphase of mitotic cell cycle
1.67 1.72e-10 GO:0051641 cellular localization
1.64 5.49e-10 GO:0033036 macromolecule localization
1.97 7.12e-10 GO:0051726 regulation of cell cycle
2.06 7.28e-10 GO:0016071 mRNA metabolic process
1.82 1.54e-09 GO:0033554 cellular response to stress
1.69 2.42e-09 GO:0051649 establishment of localization in cell
1.68 9.71e-09 GO:0008104 protein localization
1.92 1.50e-08 GO:0051276 chromosome organization
1.99 3.54e-08 GO:0006974 response to DNA damage stimulus
1.49 3.57e-08 GO:0006464 protein modification process
1.74 4.87e-08 GO:0045184 establishment of protein localization
1.75 5.05e-08 GO:0015031 protein transport
2.15 6.04e-08 GO:0006397 mRNA processing
1.46 6.63e-08 GO:0043412 macromolecule modification
1.43 1.10e-07 GO:0048523 negative regulation of cellular process
1.39 2.37e-07 GO:0048522 positive regulation of cellular process
2.55 2.60e-07 GO:0071843 cellular component biogenesis at cellular level
2.25 3.02e-07 GO:0006412 translation
2.56 3.69e-07 GO:0000375 RNA splicing, via transesterification reactions
1.39 4.14e-07 GO:0048519 negative regulation of biological process
2.19 4.40e-07 GO:0009259 ribonucleotide metabolic process
2.24 5.06e-07 GO:0008380 RNA splicing
1.52 7.01e-07 GO:0009056 catabolic process
1.94 7.98e-07 GO:0034621 cellular macromolecular complex subunit organization
1.58 8.57e-07 GO:0044085 cellular component biogenesis
2.54 1.12e-06 GO:0022613 ribonucleoprotein complex biogenesis
2.27 1.30e-06 GO:0010608 posttranscriptional regulation of gene expression
1.62 1.36e-06 GO:0032268 regulation of cellular protein metabolic process
2.52 1.37e-06 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
2.52 1.37e-06 GO:0000398 nuclear mRNA splicing, via spliceosome
2.10 1.44e-06 GO:0044419 interspecies interaction between organisms
2.09 1.66e-06 GO:0016568 chromatin modification
1.59 2.09e-06 GO:0051246 regulation of protein metabolic process
2.09 2.87e-06 GO:0051301 cell division
1.35 2.91e-06 GO:0048518 positive regulation of biological process
2.55 3.20e-06 GO:0006260 DNA replication
1.77 3.57e-06 GO:0046483 heterocycle metabolic process
2.14 3.81e-06 GO:0009150 purine ribonucleotide metabolic process
2.23 5.08e-06 GO:0034660 ncRNA metabolic process
1.56 5.47e-06 GO:0044248 cellular catabolic process
2.14 9.34e-06 GO:0009141 nucleoside triphosphate metabolic process
1.90 9.39e-06 GO:0006325 chromatin organization
2.06 1.23e-05 GO:0006281 DNA repair
1.63 1.48e-05 GO:0008219 cell death
1.64 1.85e-05 GO:0043933 macromolecular complex subunit organization
1.63 2.05e-05 GO:0016265 death
2.12 2.17e-05 GO:0009144 purine nucleoside triphosphate metabolic process
2.00 2.70e-05 GO:0034622 cellular macromolecular complex assembly
1.79 2.74e-05 GO:0055086 nucleobase, nucleoside and nucleotide metabolic process
1.68 3.90e-05 GO:0006915 apoptosis
2.10 4.10e-05 GO:0009199 ribonucleoside triphosphate metabolic process
1.15 4.39e-05 GO:0065007 biological regulation
1.83 4.62e-05 GO:0044283 small molecule biosynthetic process
1.67 4.95e-05 GO:0012501 programmed cell death
2.46 5.27e-05 GO:0043687 post-translational protein modification
2.74 5.48e-05 GO:0042254 ribosome biogenesis
1.28 5.52e-05 GO:0060255 regulation of macromolecule metabolic process
2.00 5.73e-05 GO:0010564 regulation of cell cycle process
1.93 6.46e-05 GO:0006091 generation of precursor metabolites and energy
1.16 6.82e-05 GO:0050789 regulation of biological process
2.14 6.83e-05 GO:0007346 regulation of mitotic cell cycle
1.16 6.85e-05 GO:0050794 regulation of cellular process
1.58 8.48e-05 GO:0010605 negative regulation of macromolecule metabolic process
1.90 8.64e-05 GO:0016032 viral reproduction
2.08 8.86e-05 GO:0009205 purine ribonucleoside triphosphate metabolic process
2.86 1.29e-04 GO:0009260 ribonucleotide biosynthetic process
1.71 1.34e-04 GO:0009057 macromolecule catabolic process
1.66 1.44e-04 GO:0042180 cellular ketone metabolic process
1.79 1.46e-04 GO:0006753 nucleoside phosphate metabolic process
1.79 1.46e-04 GO:0009117 nucleotide metabolic process
1.86 1.56e-04 GO:0072521 purine-containing compound metabolic process
1.77 1.59e-04 GO:0044265 cellular macromolecule catabolic process
1.54 2.15e-04 GO:0009892 negative regulation of metabolic process
1.77 2.18e-04 GO:0070727 cellular macromolecule localization
1.24 2.42e-04 GO:0019222 regulation of metabolic process
1.65 2.78e-04 GO:0065003 macromolecular complex assembly
2.19 2.84e-04 GO:0071156 regulation of cell cycle arrest
1.76 3.27e-04 GO:0034613 cellular protein localization
1.86 5.47e-04 GO:0006886 intracellular protein transport
2.19 5.71e-04 GO:0000075 cell cycle checkpoint
1.81 7.03e-04 GO:0000279 M phase
1.88 7.32e-04 GO:0044271 cellular nitrogen compound biosynthetic process
2.11 7.73e-04 GO:0018130 heterocycle biosynthetic process
1.85 8.42e-04 GO:0006163 purine nucleotide metabolic process
2.24 8.97e-04 GO:0034470 ncRNA processing
2.34 9.51e-04 GO:0006417 regulation of translation
1.62 9.73e-04 GO:0019752 carboxylic acid metabolic process
1.62 9.73e-04 GO:0043436 oxoacid metabolic process
2.57 1.13e-03 GO:0050657 nucleic acid transport
2.57 1.13e-03 GO:0050658 RNA transport
2.57 1.13e-03 GO:0051236 establishment of RNA localization
1.45 1.25e-03 GO:0031325 positive regulation of cellular metabolic process
2.11 1.34e-03 GO:0051186 cofactor metabolic process
1.89 1.48e-03 GO:0006520 cellular amino acid metabolic process
1.26 1.59e-03 GO:0006810 transport
1.49 1.67e-03 GO:0042981 regulation of apoptosis
1.26 1.96e-03 GO:0051234 establishment of localization
2.39 2.29e-03 GO:0000082 G1/S transition of mitotic cell cycle
2.49 2.56e-03 GO:0006403 RNA localization
1.23 2.58e-03 GO:0031323 regulation of cellular metabolic process
1.23 2.60e-03 GO:0051179 localization
2.73 2.66e-03 GO:0009152 purine ribonucleotide biosynthetic process
1.47 2.77e-03 GO:0043067 regulation of programmed cell death
1.64 3.02e-03 GO:0071822 protein complex subunit organization
1.58 3.14e-03 GO:0006082 organic acid metabolic process
1.70 3.42e-03 GO:0009308 amine metabolic process
1.51 3.52e-03 GO:0031324 negative regulation of cellular metabolic process
1.74 3.88e-03 GO:0044262 cellular carbohydrate metabolic process
1.46 4.29e-03 GO:0010941 regulation of cell death
2.36 4.68e-03 GO:0015931 nucleobase, nucleoside, nucleotide and nucleic acid transport
1.46 4.81e-03 GO:0022607 cellular component assembly
1.61 4.82e-03 GO:0005975 carbohydrate metabolic process
1.76 4.94e-03 GO:0044106 cellular amine metabolic process
2.20 5.04e-03 GO:0016570 histone modification
1.20 5.18e-03 GO:0051716 cellular response to stimulus
1.43 5.63e-03 GO:0010604 positive regulation of macromolecule metabolic process
1.83 6.20e-03 GO:0018193 peptidyl-amino acid modification
1.22 6.30e-03 GO:0080090 regulation of primary metabolic process
3.51 6.38e-03 GO:0006458 'de novo' protein folding
1.89 6.39e-03 GO:0000087 M phase of mitotic cell cycle
2.18 6.89e-03 GO:0006913 nucleocytoplasmic transport
1.41 7.34e-03 GO:0009893 positive regulation of metabolic process
2.50 7.38e-03 GO:0051320 S phase
2.16 8.03e-03 GO:0016569 covalent chromatin modification
2.83 8.12e-03 GO:0009142 nucleoside triphosphate biosynthetic process
2.15 9.34e-03 GO:0051169 nuclear transport
1.52 9.83e-03 GO:0031399 regulation of protein modification process
1.46 1.05e-02 GO:0032774 RNA biosynthetic process
2.22 1.05e-02 GO:0022415 viral reproductive process
2.11 1.19e-02 GO:0022411 cellular component disassembly
2.11 1.19e-02 GO:0071845 cellular component disassembly at cellular level
1.53 1.22e-02 GO:0071844 cellular component assembly at cellular level
4.11 1.29e-02 GO:0050773 regulation of dendrite development
2.44 1.32e-02 GO:0031570 DNA integrity checkpoint
1.83 1.42e-02 GO:0006511 ubiquitin-dependent protein catabolic process
2.46 1.56e-02 GO:0000084 S phase of mitotic cell cycle
2.04 1.60e-02 GO:0006605 protein targeting
2.30 1.61e-02 GO:0019058 viral infectious cycle
2.15 1.61e-02 GO:0009165 nucleotide biosynthetic process
2.65 1.85e-02 GO:0018196 peptidyl-asparagine modification
2.65 1.85e-02 GO:0018279 protein N-linked glycosylation via asparagine
2.32 1.93e-02 GO:0046034 ATP metabolic process
2.06 2.10e-02 GO:0034404 nucleobase, nucleoside and nucleotide biosynthetic process
2.06 2.10e-02 GO:0034654 nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process
1.56 2.51e-02 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.55 2.55e-02 GO:0007167 enzyme linked receptor protein signaling pathway
1.63 2.61e-02 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
2.25 2.66e-02 GO:0006310 DNA recombination
1.80 2.67e-02 GO:0019941 modification-dependent protein catabolic process
2.23 3.13e-02 GO:0006006 glucose metabolic process
1.54 3.16e-02 GO:0010558 negative regulation of macromolecule biosynthetic process
1.97 3.26e-02 GO:0009146 purine nucleoside triphosphate catabolic process
1.79 3.28e-02 GO:0043632 modification-dependent macromolecule catabolic process
2.37 3.30e-02 GO:0051188 cofactor biosynthetic process
2.09 3.36e-02 GO:0006732 coenzyme metabolic process
2.37 4.71e-02 GO:0051028 mRNA transport
1.94 4.74e-02 GO:0009143 nucleoside triphosphate catabolic process
1.94 4.74e-02 GO:0009154 purine ribonucleotide catabolic process
2.16 4.83e-02 GO:0016051 carbohydrate biosynthetic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.31 8.44e-83 GO:0044424 intracellular part
1.29 1.70e-78 GO:0005622 intracellular
1.41 6.39e-62 GO:0005737 cytoplasm
1.58 1.62e-59 GO:0044446 intracellular organelle part
1.33 3.42e-58 GO:0043229 intracellular organelle
1.33 5.58e-58 GO:0043226 organelle
1.57 9.83e-58 GO:0044422 organelle part
1.37 2.07e-57 GO:0043227 membrane-bounded organelle
1.37 2.22e-57 GO:0043231 intracellular membrane-bounded organelle
1.49 1.60e-48 GO:0044444 cytoplasmic part
1.96 9.03e-44 GO:0044428 nuclear part
1.90 3.87e-42 GO:0031974 membrane-enclosed lumen
1.89 2.60e-39 GO:0070013 intracellular organelle lumen
1.93 3.86e-39 GO:0005829 cytosol
1.87 5.59e-39 GO:0043233 organelle lumen
1.94 2.43e-34 GO:0031981 nuclear lumen
1.42 5.44e-31 GO:0005634 nucleus
1.96 1.37e-24 GO:0005654 nucleoplasm
1.51 9.63e-24 GO:0032991 macromolecular complex
2.13 3.68e-17 GO:0031967 organelle envelope
1.08 7.48e-17 GO:0044464 cell part
1.08 7.97e-17 GO:0005623 cell
2.09 2.14e-16 GO:0031975 envelope
1.77 3.68e-16 GO:0005739 mitochondrion
2.30 1.51e-15 GO:0005730 nucleolus
1.47 2.33e-14 GO:0043228 non-membrane-bounded organelle
1.47 2.33e-14 GO:0043232 intracellular non-membrane-bounded organelle
2.21 7.24e-14 GO:0030529 ribonucleoprotein complex
1.44 9.19e-14 GO:0043234 protein complex
1.53 1.56e-13 GO:0031090 organelle membrane
1.98 2.25e-12 GO:0044429 mitochondrial part
2.11 2.10e-10 GO:0005740 mitochondrial envelope
2.07 3.47e-09 GO:0031966 mitochondrial membrane
2.13 1.45e-07 GO:0019866 organelle inner membrane
1.46 6.84e-07 GO:0012505 endomembrane system
2.10 1.91e-06 GO:0005743 mitochondrial inner membrane
1.67 7.08e-06 GO:0044451 nucleoplasm part
3.09 2.68e-05 GO:0046930 pore complex
2.14 3.47e-05 GO:0005635 nuclear envelope
1.72 4.50e-05 GO:0005694 chromosome
3.16 1.58e-04 GO:0005643 nuclear pore
1.60 3.38e-04 GO:0015630 microtubule cytoskeleton
2.17 6.80e-04 GO:0005819 spindle
1.94 1.52e-03 GO:0005759 mitochondrial matrix
1.55 1.57e-03 GO:0042175 nuclear membrane-endoplasmic reticulum network
5.27 1.76e-03 GO:0030530 heterogeneous nuclear ribonucleoprotein complex
1.99 2.03e-03 GO:0005813 centrosome
1.66 2.72e-03 GO:0044427 chromosomal part
1.54 2.75e-03 GO:0005789 endoplasmic reticulum membrane
1.49 5.23e-03 GO:0044432 endoplasmic reticulum part
1.40 6.66e-03 GO:0005783 endoplasmic reticulum
2.29 7.96e-03 GO:0044455 mitochondrial membrane part
2.50 9.04e-03 GO:0016585 chromatin remodeling complex
1.70 2.12e-02 GO:0005815 microtubule organizing center
1.96 2.50e-02 GO:0031252 cell leading edge
4.49 2.93e-02 GO:0031519 PcG protein complex
2.09 2.98e-02 GO:0031965 nuclear membrane
1.93 3.62e-02 GO:0005840 ribosome
3.09 4.40e-02 GO:0016469 proton-transporting two-sector ATPase complex

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.46 1.02e-58 GO:0005515 protein binding
1.20 6.07e-38 GO:0005488 binding
2.08 1.52e-18 GO:0003723 RNA binding
1.55 4.68e-16 GO:0000166 nucleotide binding
1.30 2.42e-14 GO:0003824 catalytic activity
1.46 1.48e-08 GO:0035639 purine ribonucleoside triphosphate binding
1.46 2.04e-08 GO:0032553 ribonucleotide binding
1.46 2.04e-08 GO:0032555 purine ribonucleotide binding
1.45 2.30e-08 GO:0017076 purine nucleotide binding
1.31 1.17e-07 GO:0003676 nucleic acid binding
1.49 1.24e-07 GO:0032559 adenyl ribonucleotide binding
1.49 1.25e-07 GO:0030554 adenyl nucleotide binding
1.50 1.37e-07 GO:0005524 ATP binding
1.72 4.57e-07 GO:0019899 enzyme binding
1.40 2.52e-05 GO:0016740 transferase activity
1.79 8.20e-05 GO:0016874 ligase activity
2.24 1.70e-04 GO:0003682 chromatin binding
2.36 6.21e-04 GO:0008022 protein C-terminus binding
1.73 1.02e-03 GO:0019904 protein domain specific binding
1.75 3.35e-03 GO:0003712 transcription cofactor activity
1.74 3.68e-03 GO:0000988 protein binding transcription factor activity
1.74 3.68e-03 GO:0000989 transcription factor binding transcription factor activity
2.82 3.91e-03 GO:0042393 histone binding
1.46 4.22e-03 GO:0016772 transferase activity, transferring phosphorus-containing groups
2.57 1.35e-02 GO:0008565 protein transporter activity
2.35 1.52e-02 GO:0016779 nucleotidyltransferase activity
2.58 1.93e-02 GO:0008135 translation factor activity, nucleic acid binding
2.51 2.04e-02 GO:0035257 nuclear hormone receptor binding
2.59 2.74e-02 GO:0003729 mRNA binding
1.44 3.21e-02 GO:0016462 pyrophosphatase activity
1.44 3.82e-02 GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
1.73 4.03e-02 GO:0016879 ligase activity, forming carbon-nitrogen bonds
1.44 4.22e-02 GO:0017111 nucleoside-triphosphatase activity
1.43 4.53e-02 GO:0016817 hydrolase activity, acting on acid anhydrides