Motif ID: HIC1.p2

Z-value: 3.263


Transcription factors associated with HIC1.p2:

Gene SymbolEntrez IDGene Name
HIC1 3090 hypermethylated in cancer 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HIC1chr17_+_1958354,
chr17_+_1959512
0.451.7e-12Click!


Activity profile for motif HIC1.p2.

activity profile for motif HIC1.p2


Sorted Z-values histogram for motif HIC1.p2

Sorted Z-values for motif HIC1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HIC1.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr16_+_222845 76.681 NM_000517
HBA1
HBA2
hemoglobin, alpha 1
hemoglobin, alpha 2
chr12_+_121078421 72.117 NM_001033677
CABP1
calcium binding protein 1
chr1_+_6845381 56.867 NM_001195563
NM_001242701
NM_015215
CAMTA1


calmodulin binding transcription activator 1


chr16_+_226678 50.724 NM_000558
HBA1
HBA2
hemoglobin, alpha 1
hemoglobin, alpha 2
chr19_+_708766 49.337 NM_001040134
NM_002579
PALM

paralemmin

chr14_+_103243832 49.255 TRAF3
TNF receptor-associated factor 3
chr10_+_126150340 48.916 NM_001167880
NM_022126
LHPP

phospholysine phosphohistidine inorganic pyrophosphate phosphatase

chr11_-_12030838 47.757 DKK3
dickkopf 3 homolog (Xenopus laevis)
chr15_+_68871285 47.562 NM_006091
CORO2B
coronin, actin binding protein, 2B
chr11_-_12030882 45.209 NM_013253
DKK3
dickkopf 3 homolog (Xenopus laevis)
chr8_+_26435339 43.383 NM_001386
DPYSL2
dihydropyrimidinase-like 2
chr16_+_58497628 43.019 NDRG4
NDRG family member 4
chr9_+_137979513 42.323 OLFM1
olfactomedin 1
chr9_+_130965666 41.660 DNM1
dynamin 1
chr3_+_49027281 41.456 NM_177938
NM_177939
P4HTM

prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)

chr13_+_27131799 41.161 NM_006646
WASF3
WAS protein family, member 3
chr5_-_11904127 40.892 CTNND2
catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)
chr1_+_10270680 40.471 NM_015074
NM_183416
KIF1B

kinesin family member 1B

chr5_-_11903964 40.439 NM_001332
CTNND2
catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)
chr15_-_29862926 40.228 NM_015307
FAM189A1
family with sequence similarity 189, member A1
chr9_+_130965668 39.788 DNM1
dynamin 1
chr9_+_130965608 39.705 NM_001005336
NM_004408
DNM1

dynamin 1

chr12_+_66218879 38.160 HMGA2
high mobility group AT-hook 2
chr19_-_19006868 38.136 NM_021267
NM_198207
NM_001492
CERS1

GDF1
ceramide synthase 1

growth differentiation factor 1
chr11_-_12030539 38.079 DKK3
dickkopf 3 homolog (Xenopus laevis)
chr3_+_49027770 38.005 P4HTM
prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
chr6_-_84419018 37.562 SNAP91
synaptosomal-associated protein, 91kDa homolog (mouse)
chr16_+_58497548 37.326 NM_020465
NDRG4
NDRG family member 4
chr11_-_12030622 37.138 NM_015881
DKK3
dickkopf 3 homolog (Xenopus laevis)
chr11_-_66335958 36.933 NM_003793
CTSF
cathepsin F
chr1_-_11714396 36.028 FBXO2
F-box protein 2
chr2_+_236403290 36.013 AGAP1
ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
chr6_+_7108864 34.127 RREB1
ras responsive element binding protein 1
chr8_-_27472188 34.032 CLU
clusterin
chr7_+_45614179 33.672 ADCY1
adenylate cyclase 1 (brain)
chr2_-_224903933 33.536 NM_001136528
NM_006216
SERPINE2

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2

chrX_+_135229536 33.416 NM_001159702
NM_001159703
NM_001449
FHL1


four and a half LIM domains 1


chr6_-_112194430 33.109 FYN
FYN oncogene related to SRC, FGR, YES
chr3_+_53528586 32.411 CACNA1D
calcium channel, voltage-dependent, L type, alpha 1D subunit
chr17_+_30813928 32.393 NM_003885
CDK5R1
cyclin-dependent kinase 5, regulatory subunit 1 (p35)
chr19_+_33685489 32.286 NM_002333
LRP3
low density lipoprotein receptor-related protein 3
chr4_-_5894695 32.090 NM_001014809
CRMP1
collapsin response mediator protein 1
chr7_+_1200097 31.833


chr7_+_156742402 31.227 NM_138400
NOM1
nucleolar protein with MIF4G domain 1
chr9_+_17578952 31.124 NM_003026
SH3GL2
SH3-domain GRB2-like 2
chr6_+_107811272 30.629 NM_018013
SOBP
sine oculis binding protein homolog (Drosophila)
chr21_+_47878764 30.357 NM_001146114
NM_001146115
NM_001146116
NM_015151
NM_206889
NM_206890
NM_206891
DIP2A






DIP2 disco-interacting protein 2 homolog A (Drosophila)






chr7_-_44365019 29.951 NM_001220
NM_172078
NM_172079
NM_172080
NM_172081
NM_172082
NM_172083
NM_172084
CAMK2B







calcium/calmodulin-dependent protein kinase II beta







chr10_-_81205091 29.902 NM_153367
ZCCHC24
zinc finger, CCHC domain containing 24
chr2_+_9614636 29.642 NM_001039613
IAH1
isoamyl acetate-hydrolyzing esterase 1 homolog (S. cerevisiae)
chr2_+_241938254 29.459 NM_001080437
SNED1
sushi, nidogen and EGF-like domains 1
chr9_-_139922705 29.281 NM_001606
ABCA2
ATP-binding cassette, sub-family A (ABC1), member 2
chr19_+_33685140 29.115 LRP3
low density lipoprotein receptor-related protein 3
chr8_-_27472298 29.110 NM_001831
CLU
clusterin
chr18_-_5630629 29.071 EPB41L3
erythrocyte membrane protein band 4.1-like 3
chr19_-_460995 29.004 NM_012435
SHC2
SHC (Src homology 2 domain containing) transforming protein 2
chr15_-_43029123 28.989 CDAN1
congenital dyserythropoietic anemia, type I
chr9_-_13279562 28.925 MPDZ
multiple PDZ domain protein
chr5_+_76506705 28.479 NM_001029851
NM_001029852
NM_001029853
NM_001029854
NM_003719
PDE8B




phosphodiesterase 8B




chr17_-_31386 28.399 NM_003585
DOC2B
double C2-like domains, beta
chr11_+_120382420 28.222 GRIK4
glutamate receptor, ionotropic, kainate 4
chr7_-_994259 28.149 NM_006869
ADAP1
ArfGAP with dual PH domains 1
chr18_+_77439798 28.122 NM_004715
NM_048368
CTDP1

CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1

chr9_+_130374466 27.893 NM_001032221
NM_003165
STXBP1

syntaxin binding protein 1

chr1_-_62785067 27.890 NM_181712
KANK4
KN motif and ankyrin repeat domains 4
chr15_-_23086290 27.880 NM_144599
NIPA1
non imprinted in Prader-Willi/Angelman syndrome 1
chr19_-_56632644 27.730 NM_001002836
ZNF787
zinc finger protein 787
chr7_-_158622184 27.570 ESYT2
extended synaptotagmin-like protein 2
chr12_-_124457099 27.526 NM_025140
CCDC92
coiled-coil domain containing 92
chr2_-_99552677 27.502 NM_207362
C2orf55
chromosome 2 open reading frame 55
chr9_-_101470836 27.443 NM_005458
GABBR2
gamma-aminobutyric acid (GABA) B receptor, 2
chr14_+_100438095 27.237 EVL
Enah/Vasp-like
chr16_+_84002099 26.754 NM_019065
NECAB2
N-terminal EF-hand calcium binding protein 2
chr22_-_21213069 26.497 PI4KA
phosphatidylinositol 4-kinase, catalytic, alpha
chr22_-_21213012 26.425 PI4KA
phosphatidylinositol 4-kinase, catalytic, alpha
chr7_-_108096693 26.389 NM_001193582
NM_001193583
NM_001193584
NM_005010
NRCAM



neuronal cell adhesion molecule



chr1_-_20812727 26.290 NM_018584
CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr14_+_92789536 25.701 NM_153647
SLC24A4
solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
chr20_+_44034632 25.612 NM_001197139
NM_001048221
NM_001048222
NM_001197140
NM_018478
DBNDD2




dysbindin (dystrobrevin binding protein 1) domain containing 2




chr9_+_123963728 25.588 GSN
gelsolin
chr2_-_127864505 25.475 NM_004305
NM_139343
NM_139344
NM_139345
NM_139346
NM_139347
NM_139348
NM_139349
NM_139350
NM_139351
BIN1









bridging integrator 1









chr6_-_84419108 25.447 NM_001242793
NM_001242794
NM_014841
SNAP91


synaptosomal-associated protein, 91kDa homolog (mouse)


chr13_+_27131879 25.434 WASF3
WAS protein family, member 3
chr1_-_57044980 25.397 PPAP2B
phosphatidic acid phosphatase type 2B
chr10_-_15413054 25.312 NM_001010924
FAM171A1
family with sequence similarity 171, member A1
chr19_-_5340700 25.245 NM_002850
NM_130853
NM_130854
NM_130855
PTPRS



protein tyrosine phosphatase, receptor type, S



chr18_+_77439843 25.192 CTDP1
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
chr6_-_84418705 25.054 NM_001242792
SNAP91
synaptosomal-associated protein, 91kDa homolog (mouse)
chr11_+_121322848 24.951 NM_003105
SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr21_-_46359685 24.902 C21orf67
chromosome 21 open reading frame 67
chr8_+_104152876 24.708 NM_001024372
NM_024812
BAALC

brain and acute leukemia, cytoplasmic

chr10_+_124220990 24.476 NM_002775
HTRA1
HtrA serine peptidase 1
chr3_+_71803200 24.410 NM_018971
GPR27
G protein-coupled receptor 27
chr22_+_33197678 23.964 TIMP3
TIMP metallopeptidase inhibitor 3
chr7_-_158622202 23.906 NM_020728
ESYT2
extended synaptotagmin-like protein 2
chr5_+_7396030 23.853 NM_020546
ADCY2
adenylate cyclase 2 (brain)
chr17_+_18128868 23.784 NM_004140
LLGL1
lethal giant larvae homolog 1 (Drosophila)
chr19_+_35521591 23.755 NM_001037
NM_199037
SCN1B

sodium channel, voltage-gated, type I, beta

chrX_+_38420690 23.706 NM_004615
TSPAN7
tetraspanin 7
chr16_+_58497993 23.361 NM_001130487
NDRG4
NDRG family member 4
chr5_-_58334936 23.235 NM_001197221
NM_001197222
PDE4D

phosphodiesterase 4D, cAMP-specific

chr11_+_1411089 23.202 NM_003957
BRSK2
BR serine/threonine kinase 2
chr22_-_19511777 22.986 CLDN5
claudin 5
chr6_+_39760148 22.962 NM_001201427
DAAM2
dishevelled associated activator of morphogenesis 2
chr11_-_33890931 22.705 LMO2
LIM domain only 2 (rhombotin-like 1)
chr3_+_53529030 22.613 NM_000720
NM_001128839
NM_001128840
CACNA1D


calcium channel, voltage-dependent, L type, alpha 1D subunit


chr14_+_96505566 22.570 NM_001252507
C14orf132
chromosome 14 open reading frame 132
chr3_+_11034436 22.489 SLC6A1
solute carrier family 6 (neurotransmitter transporter, GABA), member 1
chr3_+_32148136 22.455 GPD1L
glycerol-3-phosphate dehydrogenase 1-like
chr4_-_185747051 22.373 ACSL1
acyl-CoA synthetase long-chain family member 1
chr4_+_4388717 22.187 D4S234E
DNA segment on chromosome 4 (unique) 234 expressed sequence
chr19_-_3700387 22.131 PIP5K1C
phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
chr14_+_105155724 22.099 NM_001031714
NM_022489
NM_032714
INF2


inverted formin, FH2 and WH2 domain containing


chr15_+_41851153 21.990 NM_006293
TYRO3
TYRO3 protein tyrosine kinase
chr15_+_80696569 21.910 NM_014862
ARNT2
aryl-hydrocarbon receptor nuclear translocator 2
chr2_-_224903324 21.839 NM_001136530
SERPINE2
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr9_+_124030413 21.700 GSN
gelsolin
chr9_-_135996287 21.410 NM_006266
RALGDS
ral guanine nucleotide dissociation stimulator
chr13_-_40177304 21.309 LHFP
lipoma HMGIC fusion partner
chr4_+_95679075 21.304 NM_001203
BMPR1B
bone morphogenetic protein receptor, type IB
chr11_-_33891258 21.284 LMO2
LIM domain only 2 (rhombotin-like 1)
chr17_-_10101854 21.223 NM_201433
GAS7
growth arrest-specific 7
chr14_+_92790151 21.163 NM_153646
SLC24A4
solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
chr3_-_45267804 21.045 NM_015444
TMEM158
transmembrane protein 158 (gene/pseudogene)
chr14_+_105780903 21.019 PACS2
phosphofurin acidic cluster sorting protein 2
chr9_-_139922595 21.002 ABCA2
ATP-binding cassette, sub-family A (ABC1), member 2
chr1_+_244998592 20.941 NM_198076
FAM36A
family with sequence similarity 36, member A
chr10_-_118501981 20.882 NM_025015
HSPA12A
heat shock 70kDa protein 12A
chr8_+_26435466 20.788 DPYSL2
dihydropyrimidinase-like 2
chrX_+_153237990 20.664 NM_003492
TMEM187
transmembrane protein 187
chr12_-_93323006 20.629 EEA1
early endosome antigen 1
chr6_+_147829784 20.558 NM_001030060
SAMD5
sterile alpha motif domain containing 5
chr9_+_124030370 20.415 NM_001127662
NM_001127663
NM_001127664
NM_001127665
NM_001127666
NM_001127667
NM_198252
GSN






gelsolin






chr9_+_103235634 20.382 TMEFF1
transmembrane protein with EGF-like and two follistatin-like domains 1
chr18_-_21977711 20.310 OSBPL1A
oxysterol binding protein-like 1A
chr19_-_6279927 20.296 NM_005934
MLLT1
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1
chr11_-_62554790 20.191


chr10_+_121485593 20.176 INPP5F
inositol polyphosphate-5-phosphatase F
chr2_-_27718098 20.146 NM_022823
FNDC4
fibronectin type III domain containing 4
chr11_-_113746205 20.075 NM_020886
USP28
ubiquitin specific peptidase 28
chr17_-_8066254 20.063 NM_014232
VAMP2
vesicle-associated membrane protein 2 (synaptobrevin 2)
chr3_-_127541975 19.938 NM_001003794
MGLL
monoglyceride lipase
chr5_+_134240820 19.929 PCBD2
pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2
chr10_+_124134206 19.879 PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr1_+_201476283 19.715


chr19_-_3700466 19.703 NM_001195733
NM_012398
PIP5K1C

phosphatidylinositol-4-phosphate 5-kinase, type I, gamma

chr9_+_124030455 19.701 GSN
gelsolin
chr22_-_21213099 19.700 NM_058004
PI4KA
phosphatidylinositol 4-kinase, catalytic, alpha
chr12_+_4918341 19.649 NM_002235
KCNA6
potassium voltage-gated channel, shaker-related subfamily, member 6
chr12_-_93323088 19.573 NM_003566
EEA1
early endosome antigen 1
chr7_+_45614081 19.567 NM_021116
ADCY1
adenylate cyclase 1 (brain)
chr15_+_100106214 19.550 MEF2A
myocyte enhancer factor 2A
chr12_-_93322911 19.535 EEA1
early endosome antigen 1
chr17_+_64298731 19.458 PRKCA
protein kinase C, alpha
chr2_-_69870705 19.420 AAK1
AP2 associated kinase 1
chr19_+_54926721 19.333 TTYH1
tweety homolog 1 (Drosophila)
chr4_-_185747183 19.311 NM_001995
ACSL1
acyl-CoA synthetase long-chain family member 1
chr10_+_121485638 19.274 INPP5F
inositol polyphosphate-5-phosphatase F
chr2_+_46524448 19.173 NM_001430
EPAS1
endothelial PAS domain protein 1
chr20_+_44035203 19.147 NM_001048223
NM_001048224
DBNDD2

dysbindin (dystrobrevin binding protein 1) domain containing 2

chr4_-_8873453 19.132 NM_018942
HMX1
H6 family homeobox 1
chr2_-_69870837 19.053 AAK1
AP2 associated kinase 1
chr19_-_11373117 19.014 NM_020812
DOCK6
dedicator of cytokinesis 6
chr5_+_92920592 18.915 NR2F1
NR2F2
nuclear receptor subfamily 2, group F, member 1
nuclear receptor subfamily 2, group F, member 2
chr18_+_74534458 18.815 ZNF236
zinc finger protein 236
chr1_-_32229635 18.808 NM_001703
BAI2
brain-specific angiogenesis inhibitor 2
chr5_+_134240752 18.710 NM_032151
PCBD2
pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2
chr22_-_18923654 18.708 PRODH
proline dehydrogenase (oxidase) 1
chr7_-_140624280 18.702 NM_004333
BRAF
v-raf murine sarcoma viral oncogene homolog B1
chr21_+_47878969 18.671 DIP2A
DIP2 disco-interacting protein 2 homolog A (Drosophila)
chr13_+_42031690 18.656 C13orf15
chromosome 13 open reading frame 15
chr3_+_32148000 18.652 NM_015141
GPD1L
glycerol-3-phosphate dehydrogenase 1-like
chr22_-_19512001 18.649 CLDN5
claudin 5
chr22_+_33197744 18.624 TIMP3
TIMP metallopeptidase inhibitor 3
chr17_-_74449220 18.622 UBE2O
ubiquitin-conjugating enzyme E2O
chr11_-_134281725 18.583 NM_018644
NM_054025
B3GAT1

beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)

chr7_-_51384458 18.577 NM_015198
COBL
cordon-bleu homolog (mouse)
chr22_-_39151979 18.561 SUN2
Sad1 and UNC84 domain containing 2
chr13_+_98795710 18.533 FARP1
FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
chr16_+_11762235 18.511 NM_003498
SNN
stannin
chr13_-_44361032 18.498 NM_001242863
NM_017993
ENOX1

ecto-NOX disulfide-thiol exchanger 1

chr4_+_3768295 18.498 NM_000683
ADRA2C
adrenergic, alpha-2C-, receptor
chr15_+_92397027 18.454 SLCO3A1
solute carrier organic anion transporter family, member 3A1
chr7_-_150038689 18.282 NM_002889
RARRES2
retinoic acid receptor responder (tazarotene induced) 2
chr12_-_53574690 18.258 NM_001244705
CSAD
cysteine sulfinic acid decarboxylase
chr1_+_236305831 18.229 NM_003272
GPR137B
G protein-coupled receptor 137B
chr17_-_74236272 18.223 NM_052916
RNF157
ring finger protein 157
chr14_-_105886075 18.191 LOC100507437
uncharacterized LOC100507437
chr4_-_16228071 18.159 TAPT1
transmembrane anterior posterior transformation 1
chr10_+_116853118 18.155 NM_207303
ATRNL1
attractin-like 1
chr17_+_7554711 18.077 ATP1B2
ATPase, Na+/K+ transporting, beta 2 polypeptide
chr8_+_1922030 18.054 NM_014867
KBTBD11
kelch repeat and BTB (POZ) domain containing 11
chr10_+_121485487 18.034 NM_001243195
NM_014937
INPP5F

inositol polyphosphate-5-phosphatase F

chr1_-_2322996 17.968 MORN1
MORN repeat containing 1
chr3_-_14988976 17.942 LOC100505641
uncharacterized LOC100505641
chr9_+_103235489 17.867 NM_003692
TMEFF1
transmembrane protein with EGF-like and two follistatin-like domains 1
chr1_+_19970674 17.861 NM_005380
NBL1
neuroblastoma, suppression of tumorigenicity 1
chr7_+_98246595 17.768 NM_002523
NPTX2
neuronal pentraxin II
chr10_+_49514652 17.765 MAPK8
mitogen-activated protein kinase 8
chr19_-_18717631 17.748 NM_004750
CRLF1
cytokine receptor-like factor 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.43 7.32e-46 GO:0032502 developmental process
1.45 4.73e-44 GO:0007275 multicellular organismal development
1.27 1.05e-43 GO:0050794 regulation of cellular process
1.72 1.84e-40 GO:0007399 nervous system development
1.24 1.88e-40 GO:0065007 biological regulation
1.15 5.87e-40 GO:0009987 cellular process
1.25 8.53e-40 GO:0050789 regulation of biological process
1.45 1.36e-39 GO:0048856 anatomical structure development
1.48 1.96e-39 GO:0048731 system development
1.55 3.35e-35 GO:0048869 cellular developmental process
1.55 1.12e-34 GO:0030154 cell differentiation
1.38 2.59e-33 GO:0023052 signaling
1.60 1.31e-31 GO:0023051 regulation of signaling
1.62 1.04e-29 GO:0009653 anatomical structure morphogenesis
1.77 4.55e-27 GO:0022008 neurogenesis
1.79 1.77e-26 GO:0048699 generation of neurons
1.36 3.93e-26 GO:0007165 signal transduction
1.58 7.90e-25 GO:0009966 regulation of signal transduction
1.74 9.09e-25 GO:0048468 cell development
2.02 1.18e-24 GO:0000904 cell morphogenesis involved in differentiation
1.85 2.58e-24 GO:0030182 neuron differentiation
1.92 4.48e-24 GO:0000902 cell morphogenesis
1.93 7.56e-24 GO:0048666 neuron development
1.25 8.71e-24 GO:0032501 multicellular organismal process
1.99 3.04e-23 GO:0048858 cell projection morphogenesis
2.05 4.13e-23 GO:0048812 neuron projection morphogenesis
2.05 8.41e-23 GO:0048667 cell morphogenesis involved in neuron differentiation
1.97 1.23e-22 GO:0032990 cell part morphogenesis
1.86 2.99e-22 GO:0032989 cellular component morphogenesis
1.97 1.06e-21 GO:0031175 neuron projection development
2.05 1.07e-21 GO:0007409 axonogenesis
1.84 1.26e-21 GO:0030030 cell projection organization
1.28 6.87e-20 GO:0051716 cellular response to stimulus
1.45 2.17e-19 GO:0007166 cell surface receptor linked signaling pathway
1.78 4.34e-19 GO:0007167 enzyme linked receptor protein signaling pathway
1.43 1.12e-18 GO:0048583 regulation of response to stimulus
1.59 1.51e-18 GO:0010646 regulation of cell communication
1.38 2.41e-18 GO:0048519 negative regulation of biological process
1.51 4.48e-18 GO:0035556 intracellular signal transduction
1.39 1.70e-17 GO:0048523 negative regulation of cellular process
1.84 6.15e-17 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.84 6.77e-17 GO:0007417 central nervous system development
1.41 1.26e-16 GO:0048513 organ development
1.28 2.14e-16 GO:0031323 regulation of cellular metabolic process
1.26 3.36e-16 GO:0019222 regulation of metabolic process
2.01 1.37e-15 GO:0007411 axon guidance
1.27 2.41e-15 GO:0080090 regulation of primary metabolic process
1.35 1.07e-14 GO:0042221 response to chemical stimulus
1.78 8.50e-14 GO:0019226 transmission of nerve impulse
1.78 8.50e-14 GO:0035637 multicellular organismal signaling
1.53 2.39e-13 GO:0032879 regulation of localization
1.55 4.46e-13 GO:0050793 regulation of developmental process
1.45 5.90e-13 GO:0051239 regulation of multicellular organismal process
1.80 9.52e-13 GO:0007268 synaptic transmission
1.29 1.13e-12 GO:0048518 positive regulation of biological process
1.31 1.54e-12 GO:0048522 positive regulation of cellular process
1.25 2.29e-12 GO:0051179 localization
1.54 6.72e-12 GO:0040011 locomotion
1.66 7.22e-12 GO:0009887 organ morphogenesis
1.36 7.35e-12 GO:0006464 protein modification process
1.74 1.13e-11 GO:0072358 cardiovascular system development
1.74 1.13e-11 GO:0072359 circulatory system development
1.61 1.39e-11 GO:0045595 regulation of cell differentiation
1.49 1.91e-11 GO:0006793 phosphorus metabolic process
1.49 1.91e-11 GO:0006796 phosphate metabolic process
1.25 1.93e-11 GO:0016043 cellular component organization
1.58 2.19e-11 GO:0006468 protein phosphorylation
1.24 1.16e-10 GO:0060255 regulation of macromolecule metabolic process
1.81 1.46e-10 GO:0007420 brain development
1.31 1.98e-10 GO:0065008 regulation of biological quality
1.27 4.35e-10 GO:0031326 regulation of cellular biosynthetic process
1.26 5.94e-10 GO:0009889 regulation of biosynthetic process
1.32 7.08e-10 GO:0043412 macromolecule modification
1.53 1.21e-09 GO:2000026 regulation of multicellular organismal development
1.27 1.39e-09 GO:0071842 cellular component organization at cellular level
1.53 1.43e-09 GO:0007267 cell-cell signaling
1.26 1.93e-09 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.45 3.16e-09 GO:0007154 cell communication
1.68 3.98e-09 GO:0051094 positive regulation of developmental process
1.22 5.87e-09 GO:0071840 cellular component organization or biogenesis
1.85 6.42e-09 GO:0001944 vasculature development
1.48 7.09e-09 GO:0016310 phosphorylation
1.47 9.18e-09 GO:0006351 transcription, DNA-dependent
1.25 9.32e-09 GO:0051171 regulation of nitrogen compound metabolic process
1.36 9.93e-09 GO:0065009 regulation of molecular function
1.78 1.06e-08 GO:0045597 positive regulation of cell differentiation
1.26 1.30e-08 GO:0010468 regulation of gene expression
1.54 1.34e-08 GO:0009719 response to endogenous stimulus
1.56 1.35e-08 GO:0001932 regulation of protein phosphorylation
1.14 2.93e-08 GO:0044237 cellular metabolic process
1.23 3.67e-08 GO:0051234 establishment of localization
1.52 6.65e-08 GO:0042325 regulation of phosphorylation
1.51 6.98e-08 GO:0019220 regulation of phosphate metabolic process
1.51 6.98e-08 GO:0051174 regulation of phosphorus metabolic process
1.55 7.03e-08 GO:0009725 response to hormone stimulus
1.22 1.91e-07 GO:0006810 transport
1.54 2.09e-07 GO:0010629 negative regulation of gene expression
1.69 2.16e-07 GO:0051056 regulation of small GTPase mediated signal transduction
1.89 2.24e-07 GO:0048011 nerve growth factor receptor signaling pathway
1.58 3.14e-07 GO:0006935 chemotaxis
1.58 3.14e-07 GO:0042330 taxis
1.41 3.23e-07 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.23 3.33e-07 GO:0071841 cellular component organization or biogenesis at cellular level
1.62 4.00e-07 GO:0023057 negative regulation of signaling
1.50 4.05e-07 GO:0010628 positive regulation of gene expression
1.48 4.09e-07 GO:0051049 regulation of transport
1.62 4.92e-07 GO:0010648 negative regulation of cell communication
1.80 5.87e-07 GO:0001568 blood vessel development
1.76 7.03e-07 GO:0051270 regulation of cellular component movement
1.26 7.29e-07 GO:0006355 regulation of transcription, DNA-dependent
1.44 9.78e-07 GO:0051128 regulation of cellular component organization
1.24 1.02e-06 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.55 1.30e-06 GO:0045892 negative regulation of transcription, DNA-dependent
1.69 1.45e-06 GO:0071495 cellular response to endogenous stimulus
1.76 1.52e-06 GO:0051960 regulation of nervous system development
1.13 1.63e-06 GO:0050896 response to stimulus
1.23 1.71e-06 GO:0010556 regulation of macromolecule biosynthetic process
1.58 1.77e-06 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.48 1.91e-06 GO:0031327 negative regulation of cellular biosynthetic process
1.39 2.20e-06 GO:0009892 negative regulation of metabolic process
1.62 2.32e-06 GO:0009968 negative regulation of signal transduction
1.71 2.42e-06 GO:0032870 cellular response to hormone stimulus
1.42 2.52e-06 GO:0009888 tissue development
1.70 2.66e-06 GO:0060284 regulation of cell development
1.47 2.69e-06 GO:0009890 negative regulation of biosynthetic process
1.85 3.02e-06 GO:0048514 blood vessel morphogenesis
1.24 3.09e-06 GO:0051252 regulation of RNA metabolic process
1.48 3.45e-06 GO:0010558 negative regulation of macromolecule biosynthetic process
1.74 3.50e-06 GO:0035295 tube development
1.67 3.96e-06 GO:0044057 regulation of system process
1.52 4.13e-06 GO:0051253 negative regulation of RNA metabolic process
1.48 5.28e-06 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
2.07 6.34e-06 GO:0001503 ossification
1.39 6.50e-06 GO:0010605 negative regulation of macromolecule metabolic process
1.48 6.81e-06 GO:0045893 positive regulation of transcription, DNA-dependent
1.56 7.15e-06 GO:0048646 anatomical structure formation involved in morphogenesis
1.12 7.37e-06 GO:0044238 primary metabolic process
1.42 7.84e-06 GO:0031399 regulation of protein modification process
1.48 9.01e-06 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.38 9.35e-06 GO:0032774 RNA biosynthetic process
1.37 1.06e-05 GO:0009605 response to external stimulus
1.76 1.43e-05 GO:0046578 regulation of Ras protein signal transduction
1.47 1.55e-05 GO:0051172 negative regulation of nitrogen compound metabolic process
1.62 1.73e-05 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
1.32 2.12e-05 GO:0009893 positive regulation of metabolic process
1.11 2.75e-05 GO:0008152 metabolic process
1.32 2.96e-05 GO:0010033 response to organic substance
1.65 3.28e-05 GO:0001501 skeletal system development
1.55 3.37e-05 GO:0032583 regulation of gene-specific transcription
1.58 3.84e-05 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.67 4.21e-05 GO:0019932 second-messenger-mediated signaling
1.36 4.32e-05 GO:0042127 regulation of cell proliferation
1.73 4.51e-05 GO:0050767 regulation of neurogenesis
1.64 6.45e-05 GO:0007610 behavior
1.66 6.58e-05 GO:0048729 tissue morphogenesis
1.67 6.66e-05 GO:0040012 regulation of locomotion
1.62 6.84e-05 GO:0043434 response to peptide hormone stimulus
1.35 6.88e-05 GO:0032268 regulation of cellular protein metabolic process
1.50 6.93e-05 GO:0051338 regulation of transferase activity
1.50 7.05e-05 GO:0048585 negative regulation of response to stimulus
1.70 7.09e-05 GO:2000145 regulation of cell motility
1.43 7.32e-05 GO:0051254 positive regulation of RNA metabolic process
1.42 7.38e-05 GO:0009790 embryo development
1.15 7.46e-05 GO:0044260 cellular macromolecule metabolic process
1.70 7.62e-05 GO:0030334 regulation of cell migration
1.33 7.77e-05 GO:0051246 regulation of protein metabolic process
1.52 8.85e-05 GO:0045859 regulation of protein kinase activity
1.32 8.97e-05 GO:0031325 positive regulation of cellular metabolic process
1.37 9.01e-05 GO:0031324 negative regulation of cellular metabolic process
1.54 9.14e-05 GO:0060341 regulation of cellular localization
1.50 9.30e-05 GO:0043549 regulation of kinase activity
1.55 1.09e-04 GO:0016477 cell migration
2.04 1.13e-04 GO:0007265 Ras protein signal transduction
1.96 1.13e-04 GO:0007187 G-protein signaling, coupled to cyclic nucleotide second messenger
2.19 1.17e-04 GO:0001505 regulation of neurotransmitter levels
1.86 1.23e-04 GO:0030155 regulation of cell adhesion
1.87 1.27e-04 GO:0001525 angiogenesis
1.82 1.38e-04 GO:0014070 response to organic cyclic compound
1.63 1.44e-04 GO:0022603 regulation of anatomical structure morphogenesis
1.90 1.45e-04 GO:0019935 cyclic-nucleotide-mediated signaling
1.56 1.70e-04 GO:0007264 small GTPase mediated signal transduction
1.49 1.76e-04 GO:0009967 positive regulation of signal transduction
1.40 1.78e-04 GO:0010557 positive regulation of macromolecule biosynthetic process
1.57 1.82e-04 GO:0048598 embryonic morphogenesis
1.47 1.91e-04 GO:0010647 positive regulation of cell communication
1.83 2.12e-04 GO:0030900 forebrain development
1.98 2.33e-04 GO:0010769 regulation of cell morphogenesis involved in differentiation
1.30 2.62e-04 GO:0050790 regulation of catalytic activity
1.38 2.71e-04 GO:0051173 positive regulation of nitrogen compound metabolic process
1.46 3.04e-04 GO:0023056 positive regulation of signaling
1.96 3.28e-04 GO:0022604 regulation of cell morphogenesis
2.03 3.30e-04 GO:0019933 cAMP-mediated signaling
1.72 3.43e-04 GO:0071375 cellular response to peptide hormone stimulus
1.68 3.57e-04 GO:0000165 MAPKKK cascade
1.36 3.63e-04 GO:0031328 positive regulation of cellular biosynthetic process
1.55 4.21e-04 GO:0090066 regulation of anatomical structure size
1.75 4.27e-04 GO:0045664 regulation of neuron differentiation
1.60 4.43e-04 GO:0006140 regulation of nucleotide metabolic process
1.36 4.45e-04 GO:0009891 positive regulation of biosynthetic process
1.30 4.71e-04 GO:0010604 positive regulation of macromolecule metabolic process
2.29 5.38e-04 GO:0050770 regulation of axonogenesis
1.70 5.56e-04 GO:0002009 morphogenesis of an epithelium
1.91 6.09e-04 GO:0008286 insulin receptor signaling pathway
1.93 6.39e-04 GO:0048705 skeletal system morphogenesis
2.06 6.54e-04 GO:0007188 G-protein signaling, coupled to cAMP nucleotide second messenger
2.04 6.65e-04 GO:0010720 positive regulation of cell development
1.13 7.70e-04 GO:0043170 macromolecule metabolic process
1.36 8.17e-04 GO:0048584 positive regulation of response to stimulus
1.62 8.69e-04 GO:0007423 sensory organ development
1.91 8.83e-04 GO:0030111 regulation of Wnt receptor signaling pathway
1.92 9.04e-04 GO:0030799 regulation of cyclic nucleotide metabolic process
1.94 9.23e-04 GO:0030802 regulation of cyclic nucleotide biosynthetic process
1.94 9.23e-04 GO:0030808 regulation of nucleotide biosynthetic process
2.04 9.51e-04 GO:0010863 positive regulation of phospholipase C activity
1.58 1.09e-03 GO:0051046 regulation of secretion
1.43 1.18e-03 GO:0006928 cellular component movement
1.37 1.28e-03 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
2.07 1.31e-03 GO:0051216 cartilage development
1.96 1.35e-03 GO:0030814 regulation of cAMP metabolic process
2.00 1.38e-03 GO:0010518 positive regulation of phospholipase activity
1.59 1.39e-03 GO:0051130 positive regulation of cellular component organization
1.85 1.42e-03 GO:0001655 urogenital system development
2.14 1.68e-03 GO:0060485 mesenchyme development
1.47 1.82e-03 GO:0048870 cell motility
1.47 1.82e-03 GO:0051674 localization of cell
1.97 1.94e-03 GO:0007611 learning or memory
2.01 1.96e-03 GO:0007202 activation of phospholipase C activity
2.01 1.96e-03 GO:0031279 regulation of cyclase activity
1.49 2.08e-03 GO:0007243 intracellular protein kinase cascade
1.49 2.08e-03 GO:0023014 signal transduction via phosphorylation event
1.54 2.14e-03 GO:0007389 pattern specification process
1.48 2.54e-03 GO:0006873 cellular ion homeostasis
1.91 2.56e-03 GO:0050890 cognition
1.62 2.57e-03 GO:0008361 regulation of cell size
2.09 2.62e-03 GO:0060828 regulation of canonical Wnt receptor signaling pathway
1.94 2.68e-03 GO:0030817 regulation of cAMP biosynthetic process
1.95 2.73e-03 GO:0010517 regulation of phospholipase activity
1.98 2.79e-03 GO:0006836 neurotransmitter transport
2.01 2.80e-03 GO:0045761 regulation of adenylate cyclase activity
1.61 2.90e-03 GO:0045596 negative regulation of cell differentiation
2.19 3.07e-03 GO:0048638 regulation of developmental growth
1.38 3.15e-03 GO:0071310 cellular response to organic substance
1.87 3.28e-03 GO:0051969 regulation of transmission of nerve impulse
1.51 3.53e-03 GO:0043009 chordate embryonic development
1.82 3.71e-03 GO:0031644 regulation of neurological system process
1.92 3.71e-03 GO:0050804 regulation of synaptic transmission
1.50 3.81e-03 GO:0009792 embryo development ending in birth or egg hatching
1.97 3.97e-03 GO:0051339 regulation of lyase activity
1.46 4.18e-03 GO:0055082 cellular chemical homeostasis
1.63 4.22e-03 GO:0007507 heart development
1.47 4.30e-03 GO:0040008 regulation of growth
1.53 4.36e-03 GO:0003006 developmental process involved in reproduction
1.53 4.38e-03 GO:0032535 regulation of cellular component size
1.80 4.42e-03 GO:0031344 regulation of cell projection organization
1.63 4.58e-03 GO:0030168 platelet activation
1.47 4.59e-03 GO:0008285 negative regulation of cell proliferation
1.44 4.78e-03 GO:0050801 ion homeostasis
1.91 5.25e-03 GO:0060193 positive regulation of lipase activity
1.83 5.70e-03 GO:0060191 regulation of lipase activity
1.90 7.20e-03 GO:0060541 respiratory system development
1.28 7.28e-03 GO:0010941 regulation of cell death
2.08 7.74e-03 GO:0030178 negative regulation of Wnt receptor signaling pathway
1.93 7.78e-03 GO:0001822 kidney development
1.98 8.11e-03 GO:0007626 locomotory behavior
1.67 8.13e-03 GO:0044087 regulation of cellular component biogenesis
2.00 8.14e-03 GO:0021537 telencephalon development
1.38 8.41e-03 GO:0042060 wound healing
2.98 9.38e-03 GO:0051588 regulation of neurotransmitter transport
1.68 9.48e-03 GO:0032582 negative regulation of gene-specific transcription
1.70 1.01e-02 GO:0032869 cellular response to insulin stimulus
2.10 1.08e-02 GO:0007173 epidermal growth factor receptor signaling pathway
1.68 1.10e-02 GO:0048608 reproductive structure development
1.69 1.19e-02 GO:0035239 tube morphogenesis
1.84 1.22e-02 GO:0010959 regulation of metal ion transport
1.31 1.25e-02 GO:0016265 death
1.38 1.28e-02 GO:0050878 regulation of body fluid levels
1.67 1.29e-02 GO:0043408 regulation of MAPKKK cascade
1.67 1.29e-02 GO:0048732 gland development
1.41 1.49e-02 GO:0007010 cytoskeleton organization
1.28 1.58e-02 GO:0043067 regulation of programmed cell death
2.82 1.59e-02 GO:0021954 central nervous system neuron development
2.05 1.63e-02 GO:0021953 central nervous system neuron differentiation
1.36 1.63e-02 GO:0048878 chemical homeostasis
2.03 1.65e-02 GO:0055123 digestive system development
1.30 1.78e-02 GO:0006811 ion transport
1.30 1.82e-02 GO:0008219 cell death
1.87 1.95e-02 GO:0050796 regulation of insulin secretion
1.64 2.13e-02 GO:0007548 sex differentiation
1.92 2.22e-02 GO:0030323 respiratory tube development
1.93 2.27e-02 GO:0030324 lung development
2.02 2.36e-02 GO:0050769 positive regulation of neurogenesis
1.71 2.52e-02 GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter
1.40 2.66e-02 GO:0001775 cell activation
1.86 2.74e-02 GO:0072001 renal system development
1.75 2.76e-02 GO:0045926 negative regulation of growth
2.92 2.81e-02 GO:0032231 regulation of actin filament bundle assembly
1.27 3.13e-02 GO:0042981 regulation of apoptosis
1.81 3.19e-02 GO:0002791 regulation of peptide secretion
1.81 3.19e-02 GO:0090087 regulation of peptide transport
1.70 3.20e-02 GO:0051272 positive regulation of cellular component movement
1.49 3.20e-02 GO:0051093 negative regulation of developmental process
1.62 3.27e-02 GO:0043405 regulation of MAP kinase activity
2.07 3.29e-02 GO:0031346 positive regulation of cell projection organization
1.38 3.38e-02 GO:0019725 cellular homeostasis
2.00 3.39e-02 GO:0048706 embryonic skeletal system development
1.70 3.44e-02 GO:0006813 potassium ion transport
1.28 3.91e-02 GO:0070887 cellular response to chemical stimulus
1.37 3.96e-02 GO:0007186 G-protein coupled receptor protein signaling pathway
1.79 3.99e-02 GO:0010975 regulation of neuron projection development
2.34 4.20e-02 GO:0048863 stem cell differentiation
1.67 4.37e-02 GO:0045137 development of primary sexual characteristics
1.81 4.45e-02 GO:0090276 regulation of peptide hormone secretion
1.69 4.70e-02 GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter
1.69 4.70e-02 GO:0040017 positive regulation of locomotion
2.04 4.80e-02 GO:0010721 negative regulation of cell development
1.97 4.81e-02 GO:0008016 regulation of heart contraction
1.16 4.90e-02 GO:0044267 cellular protein metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.37 5.59e-18 GO:0044459 plasma membrane part
1.09 1.13e-15 GO:0005622 intracellular
1.09 2.62e-14 GO:0044424 intracellular part
1.12 6.27e-12 GO:0005737 cytoplasm
1.74 5.27e-11 GO:0043005 neuron projection
1.46 1.05e-09 GO:0042995 cell projection
1.38 1.14e-09 GO:0031226 intrinsic to plasma membrane
1.37 5.01e-09 GO:0005887 integral to plasma membrane
1.66 8.90e-09 GO:0045202 synapse
1.44 1.92e-08 GO:0005626 insoluble fraction
1.39 7.52e-08 GO:0005794 Golgi apparatus
1.04 8.19e-08 GO:0044464 cell part
1.04 8.84e-08 GO:0005623 cell
1.42 2.91e-07 GO:0005624 membrane fraction
1.34 1.70e-06 GO:0000267 cell fraction
1.08 9.93e-06 GO:0043226 organelle
1.82 1.73e-05 GO:0030424 axon
1.15 2.00e-05 GO:0005886 plasma membrane
1.07 2.01e-05 GO:0043229 intracellular organelle
1.14 2.81e-05 GO:0071944 cell periphery
2.17 3.41e-05 GO:0008076 voltage-gated potassium channel complex
2.17 3.41e-05 GO:0034705 potassium channel complex
1.43 3.71e-05 GO:0044431 Golgi apparatus part
1.92 4.02e-05 GO:0034703 cation channel complex
1.85 6.52e-05 GO:0005912 adherens junction
1.81 6.86e-05 GO:0070161 anchoring junction
1.21 8.02e-05 GO:0005829 cytosol
1.41 1.35e-04 GO:0030054 cell junction
2.13 4.58e-04 GO:0033267 axon part
1.71 4.86e-04 GO:0031252 cell leading edge
1.55 5.26e-04 GO:0044456 synapse part
1.10 5.99e-04 GO:0044444 cytoplasmic part
1.46 8.24e-04 GO:0044463 cell projection part
1.61 9.57e-04 GO:0016323 basolateral plasma membrane
1.83 1.05e-03 GO:0031253 cell projection membrane
1.33 1.17e-03 GO:0031988 membrane-bounded vesicle
2.19 1.21e-03 GO:0031256 leading edge membrane
1.31 1.89e-03 GO:0031982 vesicle
1.91 2.01e-03 GO:0019898 extrinsic to membrane
1.90 2.84e-03 GO:0019717 synaptosome
1.32 3.39e-03 GO:0016023 cytoplasmic membrane-bounded vesicle
1.60 3.47e-03 GO:0034702 ion channel complex
1.07 4.71e-03 GO:0043231 intracellular membrane-bounded organelle
1.07 4.76e-03 GO:0043227 membrane-bounded organelle
1.39 4.98e-03 GO:0000139 Golgi membrane
1.65 6.16e-03 GO:0043025 neuronal cell body
1.63 8.75e-03 GO:0044297 cell body
1.29 1.17e-02 GO:0031410 cytoplasmic vesicle
3.09 2.42e-02 GO:0032589 neuron projection membrane
1.56 3.00e-02 GO:0030425 dendrite
1.09 3.77e-02 GO:0005634 nucleus

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.10 2.95e-22 GO:0005488 binding
1.18 4.92e-22 GO:0005515 protein binding
1.52 4.80e-14 GO:0001071 nucleic acid binding transcription factor activity
1.52 4.80e-14 GO:0003700 sequence-specific DNA binding transcription factor activity
1.63 2.22e-09 GO:0060589 nucleoside-triphosphatase regulator activity
1.64 3.09e-09 GO:0030695 GTPase regulator activity
1.51 7.54e-09 GO:0043565 sequence-specific DNA binding
1.54 9.84e-09 GO:0004672 protein kinase activity
1.40 6.51e-08 GO:0030528 transcription regulator activity
1.46 1.46e-07 GO:0019899 enzyme binding
1.18 2.49e-07 GO:0046872 metal ion binding
1.45 3.00e-07 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.59 3.82e-07 GO:0019904 protein domain specific binding
1.72 3.96e-07 GO:0005083 small GTPase regulator activity
1.17 7.31e-07 GO:0043169 cation binding
1.17 1.31e-06 GO:0043167 ion binding
1.42 1.43e-06 GO:0016301 kinase activity
1.56 2.51e-06 GO:0004674 protein serine/threonine kinase activity
1.62 1.61e-05 GO:0016563 transcription activator activity
1.87 2.42e-05 GO:0005085 guanyl-nucleotide exchange factor activity
2.10 3.89e-05 GO:0005057 receptor signaling protein activity
1.88 1.05e-04 GO:0022843 voltage-gated cation channel activity
1.34 1.10e-04 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.43 2.50e-04 GO:0008092 cytoskeletal protein binding
1.36 3.03e-04 GO:0042802 identical protein binding
1.49 5.16e-04 GO:0008047 enzyme activator activity
1.60 8.72e-04 GO:0005096 GTPase activator activity
2.02 1.06e-03 GO:0005088 Ras guanyl-nucleotide exchange factor activity
1.67 1.48e-03 GO:0010843 promoter binding
1.18 1.64e-03 GO:0003677 DNA binding
1.61 1.78e-03 GO:0019900 kinase binding
1.65 1.98e-03 GO:0000975 regulatory region DNA binding
1.65 1.98e-03 GO:0001067 regulatory region nucleic acid binding
1.65 1.98e-03 GO:0044212 transcription regulatory region DNA binding
2.06 2.11e-03 GO:0019199 transmembrane receptor protein kinase activity
1.64 6.17e-03 GO:0005244 voltage-gated ion channel activity
1.64 6.17e-03 GO:0022832 voltage-gated channel activity
1.83 6.39e-03 GO:0051020 GTPase binding
1.28 6.90e-03 GO:0030234 enzyme regulator activity
1.17 7.38e-03 GO:0046914 transition metal ion binding
1.27 7.43e-03 GO:0022892 substrate-specific transporter activity
1.18 7.77e-03 GO:0008270 zinc ion binding
1.49 8.54e-03 GO:0016564 transcription repressor activity
1.36 1.00e-02 GO:0008324 cation transmembrane transporter activity
1.74 1.02e-02 GO:0004713 protein tyrosine kinase activity
1.46 1.05e-02 GO:0042578 phosphoric ester hydrolase activity
1.19 1.06e-02 GO:0017076 purine nucleotide binding
1.51 1.42e-02 GO:0005261 cation channel activity
1.47 1.43e-02 GO:0003779 actin binding
1.59 1.48e-02 GO:0019901 protein kinase binding
1.18 1.57e-02 GO:0032553 ribonucleotide binding
1.18 1.57e-02 GO:0032555 purine ribonucleotide binding
2.09 1.77e-02 GO:0004714 transmembrane receptor protein tyrosine kinase activity
2.24 2.03e-02 GO:0004702 receptor signaling protein serine/threonine kinase activity
2.03 2.63e-02 GO:0030165 PDZ domain binding
1.47 2.81e-02 GO:0008134 transcription factor binding
1.83 2.84e-02 GO:0005249 voltage-gated potassium channel activity
1.46 3.09e-02 GO:0022836 gated channel activity
1.27 3.39e-02 GO:0022891 substrate-specific transmembrane transporter activity
1.85 4.36e-02 GO:0003704 specific RNA polymerase II transcription factor activity
1.50 4.46e-02 GO:0003702 RNA polymerase II transcription factor activity
1.70 4.96e-02 GO:0005267 potassium channel activity