Motif ID: HNF1A.p2

Z-value: 2.762


Transcription factors associated with HNF1A.p2:

Gene SymbolEntrez IDGene Name
HNF1A 6927 HNF1 homeobox A

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HNF1Achr12_+_1214165480.551.0e-18Click!


Activity profile for motif HNF1A.p2.

activity profile for motif HNF1A.p2


Sorted Z-values histogram for motif HNF1A.p2

Sorted Z-values for motif HNF1A.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HNF1A.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_-_72649734 82.669 NM_000583
GC
group-specific component (vitamin D binding protein)
chr4_+_74269971 81.924 NM_000477
ALB
albumin
chr14_-_94854910 78.232 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr14_-_94855120 75.221 NM_000295
SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr17_-_64225496 66.494 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr4_-_155511838 59.559 NM_000508
NM_021871
FGA

fibrinogen alpha chain

chr19_-_36303724 56.780 PRODH2
proline dehydrogenase (oxidase) 2
chr19_-_36303766 54.561 PRODH2
proline dehydrogenase (oxidase) 2
chr6_+_161123224 54.341 NM_000301
NM_001168338
PLG

plasminogen

chr4_+_74347461 53.178 NM_001133
AFM
afamin
chr11_+_46740769 49.387 F2
coagulation factor II (thrombin)
chr14_+_95027760 48.345 NM_006215
SERPINA4
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4
chr11_+_46740736 45.480 NM_000506
F2
coagulation factor II (thrombin)
chr15_+_58724174 44.425 NM_000236
LIPC
lipase, hepatic
chr8_-_17752847 43.477 NM_147203
NM_201553
NM_004467
NM_201552
FGL1



fibrinogen-like 1



chr17_+_41052813 40.357 NM_000151
G6PC
glucose-6-phosphatase, catalytic subunit
chr6_+_31623688 38.462 APOM
apolipoprotein M
chr1_+_159557615 38.331 NM_001639
APCS
amyloid P component, serum
chr10_+_115312777 37.513 NM_004132
HABP2
hyaluronan binding protein 2
chr3_+_149192367 35.989 NM_004617
TM4SF4
transmembrane 4 L six family member 4
chr6_+_31623668 35.629 NM_019101
APOM
apolipoprotein M
chr9_-_123812535 34.772 NM_001735
C5
complement component 5
chr5_-_135290521 33.789 NM_002302
LECT2
leukocyte cell-derived chemotaxin 2
chr2_+_234601511 33.716 NM_001072
UGT1A6
UDP glucuronosyltransferase 1 family, polypeptide A6
chr15_-_90349819 33.620 ANPEP
alanyl (membrane) aminopeptidase
chr17_+_1646129 33.265 NM_000934
NM_001165921
SERPINF2

serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2

chr2_+_234668914 32.553 NM_000463
UGT1A1
UDP glucuronosyltransferase 1 family, polypeptide A1
chr10_-_52645384 31.708 A1CF
APOBEC1 complementation factor
chr14_+_21156922 31.563 NM_001097577
NM_194431
ANG
RNASE4
angiogenin, ribonuclease, RNase A family, 5
ribonuclease, RNase A family, 4
chr10_+_5136613 30.949 AKR1C3
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr1_+_207277577 30.293 NM_000715
C4BPA
complement component 4 binding protein, alpha
chr19_+_41509825 30.130 CYP2B6
cytochrome P450, family 2, subfamily B, polypeptide 6
chr18_+_29171729 30.053 NM_000371
TTR
transthyretin
chr5_-_147211235 30.021 NM_003122
SPINK1
serine peptidase inhibitor, Kazal type 1
chr5_-_147211141 29.959 SPINK1
serine peptidase inhibitor, Kazal type 1
chr1_+_119911395 29.326 NM_001005783
NM_016527
HAO2

hydroxyacid oxidase 2 (long chain)

chr7_-_50633042 29.177 NM_001082971
DDC
dopa decarboxylase (aromatic L-amino acid decarboxylase)
chr11_-_117695408 29.123 NM_001680
FXYD2
FXYD domain containing ion transport regulator 2
chr20_+_42187705 28.968 SGK2
serum/glucocorticoid regulated kinase 2
chr10_+_5136589 28.634 AKR1C3
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr3_+_149192479 28.313 TM4SF4
transmembrane 4 L six family member 4
chr4_+_74301932 28.210 NM_001134
AFP
alpha-fetoprotein
chr2_+_234627423 27.927 NM_007120
UGT1A4
UDP glucuronosyltransferase 1 family, polypeptide A4
chr20_+_42187634 27.870 NM_170693
SGK2
serum/glucocorticoid regulated kinase 2
chr7_+_45927958 27.848 NM_000596
IGFBP1
insulin-like growth factor binding protein 1
chr14_-_94789641 27.756 NM_001756
SERPINA6
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
chr10_+_5136556 27.048 NM_003739
AKR1C3
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr10_+_135340865 26.769 NM_000773
CYP2E1
cytochrome P450, family 2, subfamily E, polypeptide 1
chr14_-_94759360 25.833 NM_016186
SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr4_-_110723127 25.019 CFI
complement factor I
chr16_+_89696674 24.981 DPEP1
dipeptidase 1 (renal)
chr4_+_69962191 24.947 NM_001074
UGT2B7
UDP glucuronosyltransferase 2 family, polypeptide B7
chr19_-_36304200 24.600 NM_021232
PRODH2
proline dehydrogenase (oxidase) 2
chr2_-_88427535 24.581 NM_001443
FABP1
fatty acid binding protein 1, liver
chr6_-_32497925 24.477 NM_002125
HLA-DRB5
major histocompatibility complex, class II, DR beta 5
chr4_+_155484131 23.902 NM_001184741
NM_005141
FGB

fibrinogen beta chain

chr19_+_11350282 23.629 NM_018687
C19orf80
chromosome 19 open reading frame 80
chrX_+_70435048 23.466 NM_001097642
GJB1
gap junction protein, beta 1, 32kDa
chr4_-_100212085 23.349 NM_000667
ADH1A
alcohol dehydrogenase 1A (class I), alpha polypeptide
chr6_+_126070724 23.244 NM_012259
HEY2
hairy/enhancer-of-split related with YRPW motif 2
chr10_-_52645430 23.067 NM_001198818
NM_001198819
NM_001198820
NM_014576
NM_138932
NM_138933
A1CF





APOBEC1 complementation factor





chrX_+_70435087 22.438 GJB1
gap junction protein, beta 1, 32kDa
chr14_-_94759594 22.195 NM_001100607
SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr3_+_186383770 22.004 NM_000412
HRG
histidine-rich glycoprotein
chr11_-_62783281 21.895 NM_001184732
NM_001184733
NM_001184736
NM_004254
SLC22A8



solute carrier family 22 (organic anion transporter), member 8



chr14_-_94759556 20.200 SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr12_-_102874299 20.189 IGF1
insulin-like growth factor 1 (somatomedin C)
chr11_+_64323089 19.467 NM_018484
SLC22A11
solute carrier family 22 (organic anion/urate transporter), member 11
chr17_+_1646290 19.016 NM_001165920
SERPINF2
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
chr16_-_66952729 18.896 NM_001204744
NM_001204745
NM_001204746
NM_004062
CDH16



cadherin 16, KSP-cadherin



chr16_-_20364029 18.873 NM_001008389
NM_003361
UMOD

uromodulin

chr16_+_89696775 18.604 DPEP1
dipeptidase 1 (renal)
chr12_-_102874158 17.927 IGF1
insulin-like growth factor 1 (somatomedin C)
chr13_+_53602829 17.897 NM_006418
OLFM4
olfactomedin 4
chr4_-_110723334 17.465 NM_000204
CFI
complement factor I
chr1_+_15764934 17.431 NM_007272
CTRC
chymotrypsin C (caldecrin)
chr12_+_21284127 17.269 NM_006446
SLCO1B1
solute carrier organic anion transporter family, member 1B1
chr2_+_234637772 17.035 NM_019093
UGT1A3
UDP glucuronosyltransferase 1 family, polypeptide A3
chr19_+_45417576 16.942 APOC1
apolipoprotein C-I
chr6_+_126070813 16.768 HEY2
hairy/enhancer-of-split related with YRPW motif 2
chr2_+_234526290 16.594 NM_019076
UGT1A8
UDP glucuronosyltransferase 1 family, polypeptide A8
chr7_-_44580857 16.345 NM_001101648
NM_013389
NPC1L1

NPC1 (Niemann-Pick disease, type C1, gene)-like 1

chr22_+_22697538 16.082


chr20_+_42984338 16.022 NM_001030003
NM_001030004
NM_175914
HNF4A


hepatocyte nuclear factor 4, alpha


chr4_+_3443659 15.883 HGFAC
HGF activator
chr1_+_17906941 15.413 NM_001011722
ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr4_-_186733372 15.338 NM_003603
NM_001145670
SORBS2

sorbin and SH3 domain containing 2

chr14_-_57960432 14.964 NM_018168
C14orf105
chromosome 14 open reading frame 105
chr4_+_3443691 14.723 NM_001528
HGFAC
HGF activator
chr4_-_70080448 14.287 NM_001073
UGT2B11
UGT2B10
UDP glucuronosyltransferase 2 family, polypeptide B11
UDP glucuronosyltransferase 2 family, polypeptide B10
chr12_-_102874321 14.159 IGF1
insulin-like growth factor 1 (somatomedin C)
chr1_-_20141593 13.777 NM_019062
RNF186
ring finger protein 186
chr15_+_58430394 13.733 NM_020980
AQP9
aquaporin 9
chr8_-_95220769 13.732 NM_004063
CDH17
cadherin 17, LI cadherin (liver-intestine)
chr2_+_234621637 13.699 NM_019078
UGT1A5
UDP glucuronosyltransferase 1 family, polypeptide A5
chr6_-_52628272 13.667 NM_000846
GSTA2
glutathione S-transferase alpha 2
chr12_-_102874373 13.548 NM_000618
NM_001111283
NM_001111285
IGF1


insulin-like growth factor 1 (somatomedin C)


chr20_-_7921068 13.536 NM_017545
HAO1
hydroxyacid oxidase (glycolate oxidase) 1
chr8_+_21911062 13.505 NM_001114137
EPB49
erythrocyte membrane protein band 4.9 (dematin)
chr12_-_102874340 13.500 IGF1
insulin-like growth factor 1 (somatomedin C)
chr6_-_32557431 13.478 NM_001243965
NM_002124
HLA-DRB1

HLA-DRB4
HLA-DRB5
major histocompatibility complex, class II, DR beta 1

major histocompatibility complex, class II, DR beta 4
major histocompatibility complex, class II, DR beta 5
chr19_-_48389571 13.442 NM_003167
SULT2A1
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chr6_+_131894343 13.430 NM_000045
NM_001244438
ARG1

arginase, liver

chr2_+_234580504 13.293 NM_021027
UGT1A9
UDP glucuronosyltransferase 1 family, polypeptide A9
chr4_-_100273831 12.982 NM_000669
ADH1C
alcohol dehydrogenase 1C (class I), gamma polypeptide
chr2_+_88047603 12.764 NM_002665
NM_001032392
PLGLB2
PLGLB1
plasminogen-like B2
plasminogen-like B1
chr4_+_74270832 12.690 ALB
albumin
chr20_+_43030005 12.407 HNF4A
hepatocyte nuclear factor 4, alpha
chr11_+_71900958 12.108 NM_000802
FOLR1
folate receptor 1 (adult)
chr5_+_175976342 11.628 NM_017675
CDHR2
cadherin-related family member 2
chr6_-_25930838 11.478 NM_005835
SLC17A2
solute carrier family 17 (sodium phosphate), member 2
chr6_-_108145507 11.141 NM_198081
SCML4
sex comb on midleg-like 4 (Drosophila)
chr6_+_25754926 10.636 NM_005495
SLC17A4
solute carrier family 17 (sodium phosphate), member 4
chr12_-_113841654 10.396 NM_006843
SDS
serine dehydratase
chr3_-_167191808 10.358 NM_006217
SERPINI2
serpin peptidase inhibitor, clade I (pancpin), member 2
chr5_+_73109342 10.305 NM_001244364
RGNEF
190 kDa guanine nucleotide exchange factor
chr6_-_29012951 10.255 NM_030903
OR2W1
olfactory receptor, family 2, subfamily W, member 1
chr11_+_114167168 10.211 NNMT
nicotinamide N-methyltransferase
chr3_-_137893745 10.134 NM_016216
DBR1
debranching enzyme homolog 1 (S. cerevisiae)
chr19_-_42133427 10.024 NM_001817
CEACAM4
carcinoembryonic antigen-related cell adhesion molecule 4
chr4_+_25658085 9.925 NM_001177999
SLC34A2
solute carrier family 34 (sodium phosphate), member 2
chr19_-_33360641 9.923 NM_001126335
NM_001243036
NM_014270
SLC7A9


solute carrier family 7 (glycoprotein-associated amino acid transporter light chain, bo,+ system), member 9


chr22_+_32439211 9.400 SLC5A1
solute carrier family 5 (sodium/glucose cotransporter), member 1
chr13_+_96085852 9.237 NM_001160100
NM_182848
CLDN10

claudin 10

chr22_-_22337131 9.140 NM_003935
TOP3B
topoisomerase (DNA) III beta
chr1_-_47407142 8.999 NM_000778
CYP4A11
cytochrome P450, family 4, subfamily A, polypeptide 11
chr15_+_48498497 8.956 NM_000338
NM_001184832
SLC12A1

solute carrier family 12 (sodium/potassium/chloride transporters), member 1

chr4_-_69434215 8.924 NM_001077
UGT2B15
UGT2B17
UDP glucuronosyltransferase 2 family, polypeptide B15
UDP glucuronosyltransferase 2 family, polypeptide B17
chr10_+_101542460 8.900 NM_000392
ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr7_-_27166638 8.733 NM_153631
HOXA3
homeobox A3
chr14_+_39703119 8.537 NM_054024
MIA2
melanoma inhibitory activity 2
chr19_-_48389514 8.489 SULT2A1
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chr21_+_39628663 8.354 NM_002243
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr11_+_71900601 8.274 NM_016724
NM_016725
FOLR1

folate receptor 1 (adult)

chr1_-_47407094 8.199 CYP4A11
cytochrome P450, family 4, subfamily A, polypeptide 11
chr16_-_87970107 8.133 NM_001739
CA5A
carbonic anhydrase VA, mitochondrial
chr20_+_56136136 8.023 NM_002591
PCK1
phosphoenolpyruvate carboxykinase 1 (soluble)
chr17_-_202557 8.021 RPH3AL
rabphilin 3A-like (without C2 domains)
chr17_+_59477473 7.980 TBX2
T-box 2
chr9_-_94712079 7.949 NM_004560
ROR2
receptor tyrosine kinase-like orphan receptor 2
chr22_+_32439250 7.903 SLC5A1
solute carrier family 5 (sodium/glucose cotransporter), member 1
chr10_+_101542554 7.863 ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr1_+_47603083 7.500 NM_001010969
CYP4A22
cytochrome P450, family 4, subfamily A, polypeptide 22
chr1_-_230849847 7.348 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr6_+_31707724 7.270 NM_002441
NM_025259
NM_172165
NM_172166
MSH5-C6orf26
MSH5



MSH5-C6orf26 readthrough (non-protein coding)
mutS homolog 5 (E. coli)



chr4_-_122854192 7.244 NM_003305
TRPC3
transient receptor potential cation channel, subfamily C, member 3
chr20_+_43029973 7.138 HNF4A
hepatocyte nuclear factor 4, alpha
chr4_-_70826712 6.992 NM_001891
CSN2
casein beta
chr2_-_87248942 6.965 NM_002665
NM_001032392
PLGLB2
PLGLB1
plasminogen-like B2
plasminogen-like B1
chr7_+_139528951 6.884 NM_001061
NM_001166253
NM_030984
TBXAS1


thromboxane A synthase 1 (platelet)


chr7_-_107443631 6.819 NM_000111
SLC26A3
solute carrier family 26, member 3
chr6_-_52668599 6.809 NM_145740
GSTA1
glutathione S-transferase alpha 1
chr2_-_162931051 6.635 NM_001935
DPP4
dipeptidyl-peptidase 4
chr12_-_8693391 6.513 NM_014358
CLEC4E
C-type lectin domain family 4, member E
chr15_+_59903980 6.469 NM_004751
GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr12_-_12291374 6.384 LRP6
low density lipoprotein receptor-related protein 6
chr1_-_197036350 6.303 NM_001994
F13B
coagulation factor XIII, B polypeptide
chr22_+_45098046 6.175 NM_181333
PRR5
proline rich 5 (renal)
chr8_-_124749573 6.162 NM_001003954
NM_004306
ANXA13

annexin A13

chr4_-_101439071 6.097 NM_001159694
NM_016242
EMCN

endomucin

chr1_-_67266930 6.053 NM_005478
INSL5
insulin-like 5
chr22_+_45098091 6.032 NM_181334
PRR5-ARHGAP8
PRR5
PRR5-ARHGAP8 readthrough
proline rich 5 (renal)
chr8_-_6735438 6.010 NM_005218
DEFB1
defensin, beta 1
chr7_-_83270746 5.902 NM_001178129
SEMA3E
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
chr1_+_104159953 5.781 NM_000699
AMY2A
amylase, alpha 2A (pancreatic)
chr13_-_103719195 5.744 NM_000452
SLC10A2
solute carrier family 10 (sodium/bile acid cotransporter family), member 2
chr6_-_25874439 5.607 NM_001098486
NM_006632
SLC17A3

solute carrier family 17 (sodium phosphate), member 3

chr4_-_165118862 5.545 NM_012403
ANP32C
acidic (leucine-rich) nuclear phosphoprotein 32 family, member C
chr7_+_141695678 5.530 NM_004668
MGAM
maltase-glucoamylase (alpha-glucosidase)
chr1_-_230849863 5.366 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr3_+_119499330 5.292 NM_003889
NM_033013
NR1I2

nuclear receptor subfamily 1, group I, member 2

chr21_+_39628869 5.290 NM_170736
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr19_+_50016500 5.254 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr19_-_43098980 5.157 NM_001816
CEACAM8
carcinoembryonic antigen-related cell adhesion molecule 8
chr11_+_114167197 5.156 NNMT
nicotinamide N-methyltransferase
chr17_-_202617 5.090 NM_001190411
NM_001190412
NM_001190413
NM_006987
RPH3AL



rabphilin 3A-like (without C2 domains)



chr3_-_169587598 5.060 NM_024727
LRRC31
leucine rich repeat containing 31
chr6_-_116381765 4.996 NM_002031
FRK
fyn-related kinase
chr20_-_17641122 4.855 RRBP1
ribosome binding protein 1 homolog 180kDa (dog)
chr11_-_118900078 4.748 NM_001164280
SLC37A4
solute carrier family 37 (glucose-6-phosphate transporter), member 4
chr1_-_42630386 4.745 NM_033553
GUCA2A
guanylate cyclase activator 2A (guanylin)
chr3_-_50340979 4.700 NM_007312
NM_033159
NM_153282
NM_153283
NM_153285
HYAL1




hyaluronoglucosaminidase 1




chr6_+_167704802 4.633 NM_001143947
NM_018974
UNC93A

unc-93 homolog A (C. elegans)

chr7_+_129015483 4.551 NM_001130722
AHCYL2
adenosylhomocysteinase-like 2
chr12_-_71551564 4.525 TSPAN8
tetraspanin 8
chr18_-_40695483 4.479 NM_002930
RIT2
Ras-like without CAAX 2
chrX_+_11311532 4.376 NM_001142
NM_182680
NM_182681
AMELX


amelogenin, X-linked


chr17_+_77020229 4.332 NM_030968
NM_198594
C1QTNF1

C1q and tumor necrosis factor related protein 1

chr1_+_54359859 4.301 NM_000792
NM_001039715
NM_001039716
NM_213593
DIO1



deiodinase, iodothyronine, type I



chr3_-_52294427 4.271 WDR82
WD repeat domain 82
chr1_-_114429996 4.233 BCL2L15
BCL2-like 15
chr4_-_69536314 4.200 NM_001076
UGT2B15
UDP glucuronosyltransferase 2 family, polypeptide B15
chr22_-_36019363 4.185 NM_203377
MB
myoglobin
chr19_-_43690558 4.158 NM_001130014
NM_002781
PSG5

pregnancy specific beta-1-glycoprotein 5

chrX_+_2958274 4.084 NM_001201538
ARSF
arylsulfatase F
chr3_-_57234279 4.084 NM_003865
HESX1
HESX homeobox 1
chr12_+_20724797 4.044 NM_001244683
PDE3A
phosphodiesterase 3A, cGMP-inhibited
chr19_+_9296269 4.041 NM_175883
OR7D2
olfactory receptor, family 7, subfamily D, member 2
chr12_+_9980076 4.037 NM_016523
KLRF1
killer cell lectin-like receptor subfamily F, member 1
chr19_-_42192095 4.019 NM_006890
CEACAM7
carcinoembryonic antigen-related cell adhesion molecule 7

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
10.55 5.76e-15 GO:0006805 xenobiotic metabolic process
10.55 5.76e-15 GO:0071466 cellular response to xenobiotic stimulus
10.47 6.91e-15 GO:0009410 response to xenobiotic stimulus
6.14 4.58e-09 GO:0008202 steroid metabolic process
2.21 9.27e-09 GO:0042221 response to chemical stimulus
3.37 1.14e-07 GO:0006082 organic acid metabolic process
2.92 2.85e-07 GO:0006629 lipid metabolic process
3.19 1.61e-06 GO:0042180 cellular ketone metabolic process
3.17 3.37e-06 GO:0019752 carboxylic acid metabolic process
3.17 3.37e-06 GO:0043436 oxoacid metabolic process
3.86 5.37e-06 GO:0071702 organic substance transport
4.38 9.10e-06 GO:0032787 monocarboxylic acid metabolic process
2.00 2.93e-05 GO:0065008 regulation of biological quality
1.47 4.45e-05 GO:0050896 response to stimulus
17.05 1.30e-04 GO:0017144 drug metabolic process
2.56 1.83e-04 GO:0070887 cellular response to chemical stimulus
11.99 3.13e-04 GO:0030193 regulation of blood coagulation
2.02 3.22e-04 GO:0044281 small molecule metabolic process
14.61 4.20e-04 GO:0030195 negative regulation of blood coagulation
14.11 5.46e-04 GO:0050819 negative regulation of coagulation
11.13 5.75e-04 GO:0050818 regulation of coagulation
8.62 1.07e-03 GO:0010951 negative regulation of endopeptidase activity
24.35 1.23e-03 GO:0051917 regulation of fibrinolysis
38.96 1.48e-03 GO:0034391 regulation of smooth muscle cell apoptosis
9.74 1.68e-03 GO:0061041 regulation of wound healing
4.38 5.14e-03 GO:0010817 regulation of hormone levels
2.64 5.69e-03 GO:0044255 cellular lipid metabolic process
58.44 6.00e-03 GO:0034392 negative regulation of smooth muscle cell apoptosis
9.98 6.60e-03 GO:0006721 terpenoid metabolic process
4.91 7.85e-03 GO:0042445 hormone metabolic process
5.19 1.12e-02 GO:0030162 regulation of proteolysis
25.97 1.20e-02 GO:0009812 flavonoid metabolic process
25.97 1.20e-02 GO:0051918 negative regulation of fibrinolysis
5.06 1.41e-02 GO:0051346 negative regulation of hydrolase activity
2.41 2.08e-02 GO:0006955 immune response
4.80 2.35e-02 GO:0006820 anion transport
43.83 2.37e-02 GO:0015712 hexose phosphate transport
43.83 2.37e-02 GO:0015760 glucose-6-phosphate transport
21.25 3.05e-02 GO:0009698 phenylpropanoid metabolic process
21.25 3.05e-02 GO:0010660 regulation of muscle cell apoptosis
5.72 3.37e-02 GO:0010466 negative regulation of peptidase activity
5.60 4.01e-02 GO:0007586 digestion
9.48 4.29e-02 GO:0008206 bile acid metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
3.38 3.87e-10 GO:0005615 extracellular space
2.27 1.15e-09 GO:0005576 extracellular region
3.18 2.65e-09 GO:0005626 insoluble fraction
3.21 3.59e-09 GO:0005624 membrane fraction
2.82 3.94e-09 GO:0000267 cell fraction
2.84 1.37e-08 GO:0044421 extracellular region part
5.25 1.12e-07 GO:0005792 microsome
2.07 1.76e-07 GO:0044459 plasma membrane part
5.07 2.06e-07 GO:0042598 vesicular fraction
5.27 7.06e-07 GO:0045177 apical part of cell
5.92 8.14e-07 GO:0016324 apical plasma membrane
2.86 2.67e-05 GO:0005789 endoplasmic reticulum membrane
10.12 3.73e-05 GO:0031983 vesicle lumen
2.79 4.45e-05 GO:0042175 nuclear membrane-endoplasmic reticulum network
1.57 6.96e-05 GO:0005886 plasma membrane
1.56 7.49e-05 GO:0071944 cell periphery
2.63 1.12e-04 GO:0044432 endoplasmic reticulum part
10.39 1.45e-04 GO:0005903 brush border
9.95 2.05e-04 GO:0031093 platelet alpha granule lumen
9.74 2.42e-04 GO:0034774 secretory granule lumen
9.35 3.34e-04 GO:0060205 cytoplasmic membrane-bounded vesicle lumen
2.12 5.23e-04 GO:0005887 integral to plasma membrane
2.08 8.37e-04 GO:0031226 intrinsic to plasma membrane
2.18 8.64e-04 GO:0005783 endoplasmic reticulum
8.20 9.28e-04 GO:0031091 platelet alpha granule
1.33 7.21e-03 GO:0044425 membrane part
1.26 1.85e-02 GO:0016020 membrane
10.08 2.09e-02 GO:0031526 brush border membrane
25.05 2.87e-02 GO:0005577 fibrinogen complex
1.32 4.80e-02 GO:0031224 intrinsic to membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
22.96 1.63e-10 GO:0015020 glucuronosyltransferase activity
6.44 3.71e-05 GO:0008194 UDP-glycosyltransferase activity
4.76 5.11e-04 GO:0016758 transferase activity, transferring hexosyl groups
19.48 1.19e-03 GO:0008514 organic anion transmembrane transporter activity
8.35 1.50e-03 GO:0033293 monocarboxylic acid binding
3.66 1.53e-03 GO:0004857 enzyme inhibitor activity
3.27 2.15e-03 GO:0022804 active transmembrane transporter activity
4.16 2.50e-03 GO:0015291 secondary active transmembrane transporter activity
5.23 2.77e-03 GO:0020037 heme binding
9.30 2.87e-03 GO:0043498 cell surface binding
9.09 3.35e-03 GO:0019825 oxygen binding
7.20 4.66e-03 GO:0005496 steroid binding
4.91 5.05e-03 GO:0046906 tetrapyrrole binding
6.05 5.71e-03 GO:0004867 serine-type endopeptidase inhibitor activity
21.25 8.12e-03 GO:0001972 retinoic acid binding
4.41 1.39e-02 GO:0004866 endopeptidase inhibitor activity
4.32 1.67e-02 GO:0031406 carboxylic acid binding
4.23 2.01e-02 GO:0061135 endopeptidase regulator activity
5.85 2.14e-02 GO:0004497 monooxygenase activity
4.18 2.26e-02 GO:0030414 peptidase inhibitor activity
3.36 2.68e-02 GO:0016757 transferase activity, transferring glycosyl groups
7.79 3.57e-02 GO:0015103 inorganic anion transmembrane transporter activity
5.44 3.59e-02 GO:0015294 solute:cation symporter activity
14.61 4.19e-02 GO:0015149 hexose transmembrane transporter activity