Motif ID: HOXA9_MEIS1.p2

Z-value: 0.751


Transcription factors associated with HOXA9_MEIS1.p2:

Gene SymbolEntrez IDGene Name
HOXA9 3205 homeobox A9
MEIS1 4211 Meis homeobox 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HOXA9chr7_-_27205148-0.111.2e-01Click!
MEIS1chr2_+_66662516,
chr2_+_66662692
0.054.6e-01Click!


Activity profile for motif HOXA9_MEIS1.p2.

activity profile for motif HOXA9_MEIS1.p2


Sorted Z-values histogram for motif HOXA9_MEIS1.p2

Sorted Z-values for motif HOXA9_MEIS1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HOXA9_MEIS1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_198608216 23.259 PTPRC
protein tyrosine phosphatase, receptor type, C
chr6_-_24936177 14.569 FAM65B
family with sequence similarity 65, member B
chr2_+_68592317 14.092 NM_002664
PLEK
pleckstrin
chr1_+_198608244 13.150 PTPRC
protein tyrosine phosphatase, receptor type, C
chr17_-_29641068 12.792 EVI2B
ecotropic viral integration site 2B
chr19_+_10828763 12.669 DNM2
dynamin 2
chr12_-_10562744 12.257 NM_001199805
KLRC4-KLRK1
KLRC4-KLRK1 readthrough
chr19_+_10828813 12.009 DNM2
dynamin 2
chr19_+_10828725 11.471 NM_001005360
NM_001005361
NM_001005362
NM_001190716
NM_004945
DNM2




dynamin 2




chr19_+_10828772 10.841 DNM2
dynamin 2
chr14_-_94856926 10.672 NM_001002235
NM_001002236
NM_001127700
NM_001127701
NM_001127702
NM_001127703
NM_001127704
NM_001127705
NM_001127706
NM_001127707
SERPINA1









serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1









chr1_+_198608136 10.390 NM_002838
NM_080921
NM_080923
PTPRC


protein tyrosine phosphatase, receptor type, C


chr12_-_109027654 10.005 NM_003006
SELPLG
selectin P ligand
chr12_-_9268513 9.067 A2M
alpha-2-macroglobulin
chr17_-_29641094 7.957 NM_006495
EVI2B
ecotropic viral integration site 2B
chr12_-_109027615 7.261 SELPLG
selectin P ligand
chr4_-_166034003 7.148 NM_001100389
TMEM192
transmembrane protein 192
chr10_+_70847817 7.142 NM_002727
SRGN
serglycin
chr18_+_2655885 6.508 NM_015295
SMCHD1
structural maintenance of chromosomes flexible hinge domain containing 1
chr2_+_68592432 6.053 PLEK
pleckstrin
chr4_-_166033924 5.918 TMEM192
transmembrane protein 192
chr17_-_29641087 5.689 EVI2B
ecotropic viral integration site 2B
chr12_-_109027565 5.616 SELPLG
selectin P ligand
chr3_-_149470230 4.702 COMMD2
COMM domain containing 2
chr12_-_9268522 4.357 NM_000014
A2M
alpha-2-macroglobulin
chr3_-_149470254 4.206 NM_016094
COMMD2
COMM domain containing 2
chr12_-_9268475 4.096 A2M
alpha-2-macroglobulin
chr3_+_111261039 4.076 CD96
CD96 molecule
chr1_-_150587879 4.049


chr2_+_219724545 3.951 NM_006522
WNT6
wingless-type MMTV integration site family, member 6
chr2_-_145277879 3.894 NM_001171653
NM_014795
ZEB2

zinc finger E-box binding homeobox 2

chr4_+_123091757 3.769 NM_015312
KIAA1109
KIAA1109
chr12_-_9268440 3.723 A2M
alpha-2-macroglobulin
chr20_-_45142192 3.607 NM_018102
NM_199441
ZNF334

zinc finger protein 334

chr18_-_47806361 3.442 NM_001204151
MBD1
methyl-CpG binding domain protein 1
chr1_+_33004771 3.300 NM_001040441
ZBTB8A
zinc finger and BTB domain containing 8A
chr11_-_111782447 3.271 NM_001885
CRYAB
crystallin, alpha B
chr12_-_16758312 3.243 NM_001243611
LMO3
LIM domain only 3 (rhombotin-like 2)
chr10_-_75401492 3.127 NM_021245
MYOZ1
myozenin 1
chr7_+_80267972 3.123 CD36
CD36 molecule (thrombospondin receptor)
chr19_-_3772208 3.060 NM_032753
RAX2
retina and anterior neural fold homeobox 2
chr21_-_48024985 2.936 NM_006272
S100B
S100 calcium binding protein B
chr12_-_46384317 2.922 SCAF11
SR-related CTD-associated factor 11
chr12_+_10457044 2.904 NM_001114396
KLRD1
killer cell lectin-like receptor subfamily D, member 1
chr7_+_115863004 2.824 NM_152829
TES
testis derived transcript (3 LIM domains)
chr10_+_70847857 2.757 SRGN
serglycin
chr1_-_178007057 2.725 LOC730102
quinone oxidoreductase-like protein 2 pseudogene
chr9_+_93589704 2.652 NM_001174167
SYK
spleen tyrosine kinase
chr3_+_111260925 2.588 NM_005816
NM_198196
CD96

CD96 molecule

chr1_-_202130677 2.548 NM_001199797
NM_002832
PTPN7

protein tyrosine phosphatase, non-receptor type 7

chr2_+_169923531 2.537 NM_199204
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr17_+_17608163 2.528


chr16_+_4838397 2.504 NM_001253790
NM_001253791
LOC440335

uncharacterized LOC440335

chr1_-_169555624 2.380 F5
coagulation factor V (proaccelerin, labile factor)
chr19_-_14910947 2.329 NM_198944
OR7C1
olfactory receptor, family 7, subfamily C, member 1
chr1_+_14031349 2.231 NM_012231
NM_015866
PRDM2

PR domain containing 2, with ZNF domain

chr3_-_52719514 2.185 NM_018313
PBRM1
polybromo 1
chr6_+_73076431 2.112 NM_001168411
RIMS1
regulating synaptic membrane exocytosis 1
chr1_-_115238091 2.082 NM_000036
NM_001172626
AMPD1

adenosine monophosphate deaminase 1

chr17_-_46608271 2.046 NM_002144
HOXB1
homeobox B1
chr17_+_16120465 2.039 NM_004278
PIGL
phosphatidylinositol glycan anchor biosynthesis, class L
chr18_-_52969714 2.028 NM_001243236
TCF4
transcription factor 4
chrX_+_135278912 2.018 NM_001159701
NM_001159699
FHL1

four and a half LIM domains 1

chr11_-_62389376 2.016 B3GAT3
beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)
chr5_+_140800536 2.006 NM_018914
NM_032091
NM_032092
PCDHGA11


protocadherin gamma subfamily A, 11


chr7_+_128578246 1.936 NM_032643
IRF5
interferon regulatory factor 5
chr1_-_169555710 1.842 NM_000130
F5
coagulation factor V (proaccelerin, labile factor)
chr7_+_143657019 1.826 NM_012369
OR2F1
olfactory receptor, family 2, subfamily F, member 1
chr22_+_23063107 1.770 IGLJ3
immunoglobulin lambda joining 3
chrX_+_64708614 1.724 NM_001010888
ZC3H12B
zinc finger CCCH-type containing 12B
chr14_-_106746056 1.723


chr11_+_71846755 1.708 NM_000804
FOLR3
folate receptor 3 (gamma)
chr13_+_52436116 1.701 NM_031290
CCDC70
coiled-coil domain containing 70
chr12_-_16757944 1.695 LMO3
LIM domain only 3 (rhombotin-like 2)
chr18_-_60986968 1.687 BCL2
B-cell CLL/lymphoma 2
chr12_-_87232635 1.644 NM_013244
MGAT4C
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr12_-_53045947 1.632 NM_000423
KRT2
keratin 2
chr1_-_159046555 1.617 NM_004833
AIM2
absent in melanoma 2
chr5_+_128300786 1.616 SLC27A6
solute carrier family 27 (fatty acid transporter), member 6
chr7_-_38313232 1.588 NM_001003799
NM_001003806
TARP

TRGV9
TCR gamma alternate reading frame protein

T cell receptor gamma variable 9
chr11_+_27062508 1.551 NM_003986
BBOX1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr6_+_27925018 1.520 NM_012367
OR2B6
olfactory receptor, family 2, subfamily B, member 6
chr6_-_138539626 1.453 NM_021635
PBOV1
prostate and breast cancer overexpressed 1
chr18_+_21572736 1.397 NM_153211
TTC39C
tetratricopeptide repeat domain 39C
chr2_+_237478379 1.391 NM_020311
CXCR7
chemokine (C-X-C motif) receptor 7
chr12_-_121342050 1.358 NM_139015
SPPL3
signal peptide peptidase-like 3
chr5_-_41261539 1.358 NM_001115131
C6
complement component 6
chr8_+_133787556 1.349 NM_016018
NM_032205
NM_198513
PHF20L1


PHD finger protein 20-like 1


chr3_-_12941547 1.346 IQSEC1
IQ motif and Sec7 domain 1
chrX_-_15333726 1.339 NM_001201583
NM_080873
ASB11

ankyrin repeat and SOCS box containing 11

chr1_+_174844655 1.332 NM_001035230
RABGAP1L
RAB GTPase activating protein 1-like
chr6_-_137540435 1.328 IFNGR1
interferon gamma receptor 1
chr6_-_28220001 1.328 NM_019110
ZKSCAN4
zinc finger with KRAB and SCAN domains 4
chr1_-_7913094 1.307 NM_006786
UTS2
urotensin 2
chr1_+_212475147 1.287 NM_001199756
PPP2R5A
protein phosphatase 2, regulatory subunit B', alpha
chr1_-_13611532 1.277 NM_001012276
PRAMEF8
PRAMEF7
PRAME family member 8
PRAME family member 7
chr18_+_72342918 1.260 NM_001146189
NM_001146190
NM_017757
ZNF407


zinc finger protein 407


chr13_-_78493902 1.260 NM_001201397
EDNRB
endothelin receptor type B
chr1_-_7913490 1.254 NM_021995
UTS2
urotensin 2
chr6_-_137540504 1.253 IFNGR1
interferon gamma receptor 1
chr3_-_56809594 1.252 NM_001128616
ARHGEF3
Rho guanine nucleotide exchange factor (GEF) 3
chr1_-_247171302 1.248 ZNF695
zinc finger protein 695
chr1_-_84326673 1.243


chr8_+_123793988 1.203 ZHX2
zinc fingers and homeoboxes 2
chr15_-_58306185 1.199 NM_170697
ALDH1A2
aldehyde dehydrogenase 1 family, member A2
chr1_+_2005424 1.198 NM_001242874
PRKCZ
protein kinase C, zeta
chr1_+_12976449 1.194 NM_001012276
PRAMEF8
PRAMEF7
PRAME family member 8
PRAME family member 7
chr3_+_42530790 1.127 NM_001251882
VIPR1
vasoactive intestinal peptide receptor 1
chr3_-_135913276 1.110 NM_001145417
MSL2
male-specific lethal 2 homolog (Drosophila)
chr1_-_13390747 1.108 NM_001012276
PRAMEF8
PRAMEF7
PRAME family member 8
PRAME family member 7
chr20_-_1638359 1.074 NM_001039508
NM_018556
NM_080816
SIRPG


signal-regulatory protein gamma


chr4_+_69313166 1.060 NM_014058
TMPRSS11E
transmembrane protease, serine 11E
chr9_+_103947316 1.056 NM_017753
LPPR1
lipid phosphate phosphatase-related protein type 1
chr5_-_137071703 1.050 NM_017415
KLHL3
kelch-like 3 (Drosophila)
chr3_+_121796695 1.047 NM_006889
NM_176892
CD86

CD86 molecule

chr7_+_80267782 1.028 NM_000072
NM_001001548
CD36

CD36 molecule (thrombospondin receptor)

chr1_-_104238785 1.017 NM_004038
NM_001008218
NM_001008219
AMY1A
AMY1B
AMY1C
amylase, alpha 1A (salivary)
amylase, alpha 1B (salivary)
amylase, alpha 1C (salivary)
chr9_-_104198045 0.986 NM_000035
ALDOB
aldolase B, fructose-bisphosphate
chr6_+_54173202 0.958 NM_014464
TINAG
tubulointerstitial nephritis antigen
chr9_+_4792974 0.948 RCL1
RNA terminal phosphate cyclase-like 1
chr5_+_68800003 0.932 NM_001205255
OCLN
occludin
chr12_+_8975149 0.929 NM_144670
A2ML1
alpha-2-macroglobulin-like 1
chr8_-_42698447 0.909 NM_018105
NM_199003
THAP1

THAP domain containing, apoptosis associated protein 1

chr8_+_123794043 0.885 ZHX2
zinc fingers and homeoboxes 2
chr1_-_169599349 0.867 NM_003005
SELP
selectin P (granule membrane protein 140kDa, antigen CD62)
chr16_-_24942662 0.865 ARHGAP17
Rho GTPase activating protein 17
chr3_+_35722428 0.858 NM_198399
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr12_-_10562142 0.857 NM_013431
KLRC4-KLRK1
KLRC4
KLRC4-KLRK1 readthrough
killer cell lectin-like receptor subfamily C, member 4
chr3_+_155838336 0.853 NM_172160
KCNAB1
potassium voltage-gated channel, shaker-related subfamily, beta member 1
chr5_-_22853435 0.849 CDH12
cadherin 12, type 2 (N-cadherin 2)
chr1_+_104292439 0.841 NM_004038
NM_001008218
NM_001008219
AMY1A
AMY1B
AMY1C
amylase, alpha 1A (salivary)
amylase, alpha 1B (salivary)
amylase, alpha 1C (salivary)
chr6_-_166796363 0.830 BRP44L
brain protein 44-like
chr1_+_104198301 0.822 NM_004038
NM_001008218
NM_001008219
AMY1A
AMY1B
AMY1C
amylase, alpha 1A (salivary)
amylase, alpha 1B (salivary)
amylase, alpha 1C (salivary)
chr21_-_37838724 0.802 NM_012130
CLDN14
claudin 14
chr1_+_158979681 0.780 NM_001206567
NM_005531
IFI16

interferon, gamma-inducible protein 16

chr3_-_56502364 0.769 NM_015576
ERC2
ELKS/RAB6-interacting/CAST family member 2
chr18_-_3011944 0.761 NM_014646
LPIN2
lipin 2
chr18_+_72166568 0.754 CNDP2
CNDP dipeptidase 2 (metallopeptidase M20 family)
chr17_-_10452939 0.742 NM_001100112
NM_017534
MYH2

myosin, heavy chain 2, skeletal muscle, adult

chr11_-_107582733 0.742 NM_003063
SLN
sarcolipin
chr6_-_29343063 0.739 NM_030959
OR12D3
olfactory receptor, family 12, subfamily D, member 3
chr6_-_117747017 0.722 NM_002944
ROS1
c-ros oncogene 1 , receptor tyrosine kinase
chr3_+_148545587 0.711 NM_001871
CPB1
carboxypeptidase B1 (tissue)
chr3_-_150966901 0.697 NM_001081455
P2RY14
purinergic receptor P2Y, G-protein coupled, 14
chr7_-_137028275 0.695 PTN
pleiotrophin
chr19_-_52490050 0.686 NM_021632
ZNF350
zinc finger protein 350
chr19_-_14224979 0.683 NM_207518
PRKACA
protein kinase, cAMP-dependent, catalytic, alpha
chr2_-_1926501 0.677 MYT1L
myelin transcription factor 1-like
chr4_+_72102249 0.670 SLC4A4
solute carrier family 4, sodium bicarbonate cotransporter, member 4
chr6_-_46889620 0.639 NM_001098518
GPR116
G protein-coupled receptor 116
chr12_-_120765555 0.631 NM_000928
PLA2G1B
phospholipase A2, group IB (pancreas)
chr7_-_107443631 0.631 NM_000111
SLC26A3
solute carrier family 26, member 3
chr1_+_153232178 0.627 NM_000427
LOR
loricrin
chr4_-_87028805 0.626 NM_138981
MAPK10
mitogen-activated protein kinase 10
chr21_+_40823779 0.622 NM_007341
SH3BGR
SH3 domain binding glutamic acid-rich protein
chr7_+_44646120 0.608 NM_001003941
NM_001165036
NM_002541
OGDH


oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)


chr10_-_46619935 0.596 NM_001042357
NM_001042389
PTPN20B
PTPN20A
protein tyrosine phosphatase, non-receptor type 20B
protein tyrosine phosphatase, non-receptor type 20A
chr12_-_99548471 0.575 NM_001204068
NM_001204069
NM_001204070
NM_020140
NM_181670
NM_001204066
ANKS1B





ankyrin repeat and sterile alpha motif domain containing 1B





chrX_-_101112548 0.571 NM_032946
NXF5
nuclear RNA export factor 5
chr20_-_45313122 0.569 NM_001011554
NM_001193340
SLC13A3

solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3

chr2_+_233897381 0.559 NM_005383
NEU2
sialidase 2 (cytosolic sialidase)
chr5_-_176739291 0.558 NM_001142935
NM_031300
MXD3

MAX dimerization protein 3

chr4_-_48136245 0.557 NM_003328
TXK
TXK tyrosine kinase
chr2_+_204732509 0.554 NM_001037631
NM_005214
CTLA4

cytotoxic T-lymphocyte-associated protein 4

chr3_+_111717585 0.554 NM_001008272
NM_013259
TAGLN3

transgelin 3

chr15_+_42651697 0.546 NM_000070
NM_024344
NM_173087
CAPN3


calpain 3, (p94)


chr11_+_99426872 0.545 NM_175566
CNTN5
contactin 5
chr20_+_16728997 0.539 NM_020157
OTOR
otoraplin
chr10_+_18549583 0.536 NM_000724
CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chr6_-_22297729 0.526 NM_000948
PRL
prolactin
chr6_-_26235160 0.524 NM_005320
HIST1H1D
histone cluster 1, H1d
chr12_+_109577201 0.523 NM_001093
ACACB
acetyl-CoA carboxylase beta
chr6_-_39902140 0.520 NM_001075098
MOCS1
molybdenum cofactor synthesis 1
chr18_+_72166822 0.519 NM_001168499
CNDP2
CNDP dipeptidase 2 (metallopeptidase M20 family)
chr5_-_35118223 0.513 NM_001204314
NM_001204315
NM_001204316
NM_001204317
NM_001204318
PRLR




prolactin receptor




chr15_+_48498497 0.508 NM_000338
NM_001184832
SLC12A1

solute carrier family 12 (sodium/potassium/chloride transporters), member 1

chr19_-_15235748 0.500 ILVBL
ilvB (bacterial acetolactate synthase)-like
chr10_-_99052358 0.487 ARHGAP19
Rho GTPase activating protein 19
chr7_+_154720154 0.487 LOC100132707
uncharacterized LOC100132707
chr19_+_51358170 0.480 NM_001030047
NM_001030048
NM_001030050
NM_001648
KLK3



kallikrein-related peptidase 3



chr11_-_73720281 0.466 NM_003356
NM_022803
UCP3

uncoupling protein 3 (mitochondrial, proton carrier)

chr16_+_69958900 0.459 NM_199424
WWP2
WW domain containing E3 ubiquitin protein ligase 2
chr5_-_160112266 0.453 ATP10B
ATPase, class V, type 10B
chr9_-_21385258 0.445 NM_000605
IFNA2
interferon, alpha 2
chr2_-_2334887 0.445 NM_015025
MYT1L
myelin transcription factor 1-like
chr7_-_92747269 0.434 SAMD9
sterile alpha motif domain containing 9
chr1_-_8003224 0.425 NM_001561
TNFRSF9
tumor necrosis factor receptor superfamily, member 9
chr2_-_153032141 0.425 NM_005843
STAM2
signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
chr19_+_42212612 0.424 CEACAM5
carcinoembryonic antigen-related cell adhesion molecule 5
chr18_-_52625278 0.418 NM_001143829
CCDC68
coiled-coil domain containing 68
chr19_-_47164289 0.409 NM_145056
DACT3
dapper, antagonist of beta-catenin, homolog 3 (Xenopus laevis)
chr21_-_36252872 0.409 RUNX1
runt-related transcription factor 1
chr9_-_21207141 0.402 NM_002171
IFNA10
interferon, alpha 10
chrX_-_77582979 0.400 NM_006639
CYSLTR1
cysteinyl leukotriene receptor 1
chr7_-_84751246 0.399 NM_152754
SEMA3D
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D
chr3_-_52864687 0.398 NM_001166449
NM_002218
ITIH4

inter-alpha-trypsin inhibitor heavy chain family, member 4

chr6_+_153071931 0.385 NM_003381
NM_194435
VIP

vasoactive intestinal peptide

chr9_+_135937364 0.385 NM_001807
CEL
carboxyl ester lipase (bile salt-stimulated lipase)
chr4_-_83347778 0.368 HNRPDL
heterogeneous nuclear ribonucleoprotein D-like
chr7_+_90339146 0.366 CDK14
cyclin-dependent kinase 14

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
3.78 2.67e-04 GO:0050776 regulation of immune response
2.45 4.45e-04 GO:0002376 immune system process
2.96 1.40e-03 GO:0002682 regulation of immune system process
2.64 6.64e-03 GO:0006952 defense response
2.63 1.63e-02 GO:0006955 immune response

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.54 1.57e-03 GO:0005886 plasma membrane
1.52 2.69e-03 GO:0071944 cell periphery
1.76 7.52e-03 GO:0044459 plasma membrane part
2.37 8.55e-03 GO:0005626 insoluble fraction
33.36 9.54e-03 GO:0005579 membrane attack complex
1.95 4.25e-02 GO:0005887 integral to plasma membrane

Nothing significant found in function category.