Motif ID: HSF1,2.p2

Z-value: 1.281


Transcription factors associated with HSF1,2.p2:

Gene SymbolEntrez IDGene Name
HSF1 3297 heat shock transcription factor 1
HSF2 3298 heat shock transcription factor 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HSF1chr8_+_145515244,
chr8_+_145515279
-0.202.9e-03Click!
HSF2chr6_+_1227206850.143.7e-02Click!


Activity profile for motif HSF1,2.p2.

activity profile for motif HSF1,2.p2


Sorted Z-values histogram for motif HSF1,2.p2

Sorted Z-values for motif HSF1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HSF1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_-_111782447 21.064 NM_001885
CRYAB
crystallin, alpha B
chr2_-_224903324 17.865 NM_001136530
SERPINE2
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr6_+_31783280 17.535 NM_005345
HSPA1A
heat shock 70kDa protein 1A
chr3_-_123411185 15.659 MYLK
myosin light chain kinase
chr6_+_31783314 14.919 HSPA1A
HSPA1B
heat shock 70kDa protein 1A
heat shock 70kDa protein 1B
chr18_+_29171729 14.036 NM_000371
TTR
transthyretin
chr4_+_41258895 11.757 NM_004181
UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr6_+_151646634 11.154 NM_144497
AKAP12
A kinase (PRKA) anchor protein 12
chr4_+_41258909 11.119 UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr4_+_41258941 11.023 UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr9_-_88715024 10.747 NM_177937
GOLM1
golgi membrane protein 1
chr7_+_75931829 10.149 NM_001540
HSPB1
heat shock 27kDa protein 1
chr7_+_75931991 10.062 HSPB1
heat shock 27kDa protein 1
chr7_+_134464417 9.919 CALD1
caldesmon 1
chr14_-_60097531 9.685 NM_206852
RTN1
reticulon 1
chr12_+_119616594 9.653 NM_014365
HSPB8
heat shock 22kDa protein 8
chr8_-_110620220 9.390 SYBU
syntabulin (syntaxin-interacting)
chr7_+_134464161 9.032 NM_004342
NM_033138
NM_033157
CALD1


caldesmon 1


chr3_+_158787040 8.948 NM_001197113
NM_001197114
NM_001042705
NM_001042706
NM_001197100
IQCJ-SCHIP1

IQCJ


IQCJ-SCHIP1 readthrough

IQ motif containing J


chr17_-_42992852 8.579 NM_001131019
NM_001242376
NM_002055
GFAP


glial fibrillary acidic protein


chr3_+_45067750 8.563 NM_003278
CLEC3B
C-type lectin domain family 3, member B
chr11_-_119294242 8.325 NM_006288
THY1
Thy-1 cell surface antigen
chr6_+_31795395 7.813 NM_005346
HSPA1A
HSPA1B
heat shock 70kDa protein 1A
heat shock 70kDa protein 1B
chr14_-_52535737 7.692 NID2
nidogen 2 (osteonidogen)
chr14_-_60337350 7.423 NM_021136
RTN1
reticulon 1
chr20_+_19870209 7.180 NM_018993
RIN2
Ras and Rab interactor 2
chr8_-_82359620 7.077 NM_002677
PMP2
peripheral myelin protein 2
chrX_+_135230736 6.629 NM_001159700
FHL1
four and a half LIM domains 1
chrX_+_135278912 6.532 NM_001159701
NM_001159699
FHL1

four and a half LIM domains 1

chr14_-_60097223 6.242 RTN1
reticulon 1
chr3_-_42917191 6.191 CYP8B1
cytochrome P450, family 8, subfamily B, polypeptide 1
chr3_+_133495925 6.137 TF
transferrin
chr12_-_45269340 6.094 NM_001145109
NELL2
NEL-like 2 (chicken)
chr16_+_3115638 6.052 NM_001012634
IL32
interleukin 32
chr17_+_74553845 5.882 LOC100507246
uncharacterized LOC100507246
chr16_+_3115611 5.838 NM_001012635
IL32
interleukin 32
chr6_+_31783530 5.835 HSPA1A
HSPA1B
heat shock 70kDa protein 1A
heat shock 70kDa protein 1B
chr8_-_27472188 5.831 CLU
clusterin
chr7_-_150038689 5.808 NM_002889
RARRES2
retinoic acid receptor responder (tazarotene induced) 2
chr1_-_149889362 5.662 NM_014849
SV2A
synaptic vesicle glycoprotein 2A
chr16_+_3115312 5.607 NM_001012631
NM_001012633
NM_001012718
NM_004221
IL32



interleukin 32



chr16_+_226678 5.604 NM_000558
HBA1
HBA2
hemoglobin, alpha 1
hemoglobin, alpha 2
chr8_-_12973752 5.509 NM_001164271
DLC1
deleted in liver cancer 1
chr2_+_113816684 5.439 NM_012275
IL36RN
interleukin 36 receptor antagonist
chr12_-_45270071 5.361 NELL2
NEL-like 2 (chicken)
chr10_+_95848811 5.342 NM_001165979
PLCE1
phospholipase C, epsilon 1
chr16_+_222845 5.307 NM_000517
HBA1
HBA2
hemoglobin, alpha 1
hemoglobin, alpha 2
chr7_+_130126035 5.227 NM_177524
MEST
mesoderm specific transcript homolog (mouse)
chr5_+_17217781 5.223 BASP1
brain abundant, membrane attached signal protein 1
chr16_+_3115641 5.179 NM_001012632
NM_001012636
IL32

interleukin 32

chr13_+_111134933 5.147 COL4A2
collagen, type IV, alpha 2
chr4_+_71263598 5.122 NM_021225
PROL1
proline rich, lacrimal 1
chr6_-_84419018 5.045 SNAP91
synaptosomal-associated protein, 91kDa homolog (mouse)
chr8_-_26371387 4.994 NM_007257
PNMA2
paraneoplastic antigen MA2
chr16_+_56659679 4.940 MT1E
metallothionein 1E
chr4_-_57547845 4.913 NM_001145460
NM_032495
NM_139212
HOPX


HOP homeobox


chr14_-_52535945 4.905 NM_007361
NID2
nidogen 2 (osteonidogen)
chr6_-_84419108 4.850 NM_001242793
NM_001242794
NM_014841
SNAP91


synaptosomal-associated protein, 91kDa homolog (mouse)


chr7_+_30960914 4.841 NM_001185060
NM_001185061
NM_001185062
AQP1


aquaporin 1 (Colton blood group)


chr16_+_3115639 4.767 IL32
interleukin 32
chr3_-_42917632 4.765 NM_004391
CYP8B1
cytochrome P450, family 8, subfamily B, polypeptide 1
chr5_+_87564840 4.765 LOC100505894
uncharacterized LOC100505894
chr5_+_36608430 4.759 NM_001166695
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr9_-_88714395 4.700 GOLM1
golgi membrane protein 1
chr1_+_12834983 4.666 NM_001080830
PRAMEF12
PRAME family member 12
chrX_+_135251795 4.455 NM_001167819
FHL1
four and a half LIM domains 1
chr12_+_51318743 4.409 METTL7A
methyltransferase like 7A
chr14_-_52535711 4.408 NID2
nidogen 2 (osteonidogen)
chr5_-_146833150 4.391 NM_001387
DPYSL3
dihydropyrimidinase-like 3
chr17_+_44068828 4.365 MAPT
microtubule-associated protein tau
chr11_+_69467210 4.309 CCND1
cyclin D1
chr19_-_2085227 4.305 MOB3A
MOB kinase activator 3A
chr3_-_13057130 4.297


chrX_-_102941582 4.281 NM_001142418
NM_001142423
NM_001142424
NM_001142425
NM_001142426
NM_001142429
NM_001142430
NM_012286
MORF4L2







mortality factor 4 like 2







chr16_+_71392637 4.262 CALB2
calbindin 2
chr14_-_52535765 4.204 NID2
nidogen 2 (osteonidogen)
chr20_+_4666796 4.198 NM_000311
NM_001080121
NM_001080122
NM_183079
NM_001080123
PRNP




prion protein




chr12_-_9268440 4.191 A2M
alpha-2-macroglobulin
chr6_+_31913708 4.178 NM_001710
CFB
complement factor B
chr14_-_60097314 4.136 RTN1
reticulon 1
chr21_-_27512668 4.124 NM_001136016
APP
amyloid beta (A4) precursor protein
chr16_+_71392615 4.106 NM_001740
NM_007088
CALB2

calbindin 2

chr12_-_45269953 4.101 NELL2
NEL-like 2 (chicken)
chr9_-_88714460 4.097 GOLM1
golgi membrane protein 1
chr9_-_75567915 4.093 ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr12_+_51318515 4.079 NM_014033
METTL7A
methyltransferase like 7A
chr19_+_15218141 4.069 NM_033025
SYDE1
synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
chr20_+_36149606 4.063 NM_005386
NM_181689
NNAT

neuronatin

chr9_-_75568232 4.036 NM_000689
ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr15_+_68924326 4.021 NM_001190457
CORO2B
coronin, actin binding protein, 2B
chr6_-_84140854 4.019 NM_002395
ME1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr20_+_30193083 4.016 NM_002165
NM_181353
ID1

inhibitor of DNA binding 1, dominant negative helix-loop-helix protein

chr8_-_27472298 4.000 NM_001831
CLU
clusterin
chr6_+_31913763 3.998 CFB
complement factor B
chr6_+_29364331 3.994 NM_013936
OR12D2
olfactory receptor, family 12, subfamily D, member 2
chr3_+_159557745 3.944 SCHIP1
schwannomin interacting protein 1
chrX_-_107225588 3.940 NM_031273
TEX13B
testis expressed 13B
chr10_+_124220990 3.938 NM_002775
HTRA1
HtrA serine peptidase 1
chrX_+_135251454 3.904 NM_001159704
FHL1
four and a half LIM domains 1
chr2_-_188419185 3.890 NM_001032281
NM_006287
TFPI

tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)

chr8_-_7274353 3.879 NM_001205266
DEFB4B
defensin, beta 4B
chr19_+_41509825 3.876 CYP2B6
cytochrome P450, family 2, subfamily B, polypeptide 6
chr19_-_56348127 3.865 NM_145007
NLRP11
NLR family, pyrin domain containing 11
chr9_-_91793375 3.796 SHC3
SHC (Src homology 2 domain containing) transforming protein 3
chr3_-_123339423 3.782 NM_053031
NM_053032
MYLK

myosin light chain kinase

chr7_+_94024201 3.739 COL1A2
collagen, type I, alpha 2
chr10_-_53459309 3.729 NM_015235
CSTF2T
cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant
chr7_+_97361270 3.712 NM_003182
NM_013996
NM_013997
NM_013998
TAC1



tachykinin, precursor 1



chr14_+_29236882 3.704 FOXG1
forkhead box G1
chr8_-_110657745 3.682 NM_001099751
NM_001099752
SYBU

syntabulin (syntaxin-interacting)

chr7_-_80548322 3.620 SEMA3C
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr11_+_67007484 3.617 LOC100131150
uncharacterized LOC100131150
chr9_-_95298251 3.613 NM_001197295
NM_001197296
NM_001393
ECM2


extracellular matrix protein 2, female organ and adipocyte specific


chr18_-_64271215 3.602 NM_021153
CDH19
cadherin 19, type 2
chr1_-_161193375 3.560 NM_001643
APOA2
apolipoprotein A-II
chr3_-_14988976 3.558 LOC100505641
uncharacterized LOC100505641
chr2_-_190044330 3.534 NM_000393
COL5A2
collagen, type V, alpha 2
chr2_-_217560247 3.524 NM_000599
IGFBP5
insulin-like growth factor binding protein 5
chr7_-_80548666 3.514 NM_006379
SEMA3C
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr6_-_39895317 3.498 NM_005943
MOCS1
molybdenum cofactor synthesis 1
chr3_+_101443436 3.473 NM_024548
CEP97
centrosomal protein 97kDa
chr12_+_58138663 3.426 NM_005981
TSPAN31
tetraspanin 31
chr19_-_6720585 3.421 NM_000064
C3
complement component 3
chr13_-_31736031 3.398 NM_006644
HSPH1
heat shock 105kDa/110kDa protein 1
chrX_-_102319096 3.397 NM_018476
BEX1
brain expressed, X-linked 1
chr9_-_34710062 3.396 NM_002989
CCL21
chemokine (C-C motif) ligand 21
chr14_-_22005035 3.384 NM_005407
SALL2
sal-like 2 (Drosophila)
chr2_+_113816214 3.350 NM_173170
IL36RN
interleukin 36 receptor antagonist
chr10_+_7745284 3.349 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr7_+_134464372 3.345 CALD1
caldesmon 1
chr11_-_63381907 3.326 NM_007069
PLA2G16
phospholipase A2, group XVI
chr9_-_88714486 3.325 NM_016548
GOLM1
golgi membrane protein 1
chr10_+_7745229 3.309 NM_002216
ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr18_-_812268 3.296 NM_005433
YES1
v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1
chr5_+_140864626 3.291 NM_018928
NM_032406
PCDHGC4

protocadherin gamma subfamily C, 4

chr2_-_152830448 3.286 NM_001005747
CACNB4
calcium channel, voltage-dependent, beta 4 subunit
chrX_-_51239426 3.270 NM_018159
NUDT11
nudix (nucleoside diphosphate linked moiety X)-type motif 11
chr9_-_98079856 3.264 NM_000136
NM_001243744
FANCC

Fanconi anemia, complementation group C

chr3_+_159557649 3.259 NM_001197109
SCHIP1
schwannomin interacting protein 1
chr11_-_63381840 3.258 PLA2G16
phospholipase A2, group XVI
chr3_-_14988939 3.257 LOC100505641
uncharacterized LOC100505641
chr11_-_114466397 3.255 FAM55D
family with sequence similarity 55, member D
chr7_-_120498128 3.255 NM_012338
TSPAN12
tetraspanin 12
chr4_-_155533882 3.251 NM_000509
NM_021870
FGG

fibrinogen gamma chain

chr5_+_82373316 3.237 NM_003401
NM_022406
NM_022550
XRCC4


X-ray repair complementing defective repair in Chinese hamster cells 4


chr2_+_28616346 3.233 FOSL2
FOS-like antigen 2
chr2_+_66662692 3.231 MEIS1
Meis homeobox 1
chr1_-_184006828 3.227 NM_015101
GLT25D2
glycosyltransferase 25 domain containing 2
chrX_-_31526414 3.210 NM_004014
DMD
dystrophin
chr11_-_71791734 3.205 NUMA1
nuclear mitotic apparatus protein 1
chr2_+_26915390 3.199 NM_002246
KCNK3
potassium channel, subfamily K, member 3
chr6_+_129204285 3.193 NM_000426
NM_001079823
LAMA2

laminin, alpha 2

chr9_+_139921915 3.192 NM_207511
C9orf139
chromosome 9 open reading frame 139
chr20_-_44540685 3.172 PLTP
phospholipid transfer protein
chr11_+_45868668 3.165 NM_001127457
CRY2
cryptochrome 2 (photolyase-like)
chr3_-_183273407 3.149 NM_130446
KLHL6
kelch-like 6 (Drosophila)
chr10_+_7745341 3.137 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr16_+_56716378 3.136 NM_005952
MT1X
metallothionein 1X
chr10_-_28571014 3.136 NM_173496
MPP7
membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)
chr17_+_21308447 3.130 NM_001194958
KCNJ18
potassium inwardly-rectifying channel, subfamily J, member 18
chr11_-_63381485 3.129 PLA2G16
phospholipase A2, group XVI
chr19_-_52900966 3.113 LOC284373
uncharacterized LOC284373
chr11_+_64323089 3.113 NM_018484
SLC22A11
solute carrier family 22 (organic anion/urate transporter), member 11
chr2_+_219824346 3.106 NM_003936
CDK5R2
cyclin-dependent kinase 5, regulatory subunit 2 (p39)
chr2_-_97405799 3.096 NM_001142292
NM_030805
LMAN2L

lectin, mannose-binding 2-like

chr4_-_155533757 3.081 FGG
fibrinogen gamma chain
chr6_+_31913852 3.072 CFB
complement factor B
chr11_-_86383653 3.061 NM_001161586
ME3
malic enzyme 3, NADP(+)-dependent, mitochondrial
chr19_-_14629235 3.060


chr12_-_13103317 3.056 NM_018654
GPRC5D
G protein-coupled receptor, family C, group 5, member D
chr1_+_101185195 3.015 NM_001078
NM_001199834
NM_080682
VCAM1


vascular cell adhesion molecule 1


chr19_+_9296269 3.014 NM_175883
OR7D2
olfactory receptor, family 7, subfamily D, member 2
chr3_+_133464883 3.012 NM_001063
TF
transferrin
chr6_+_42531767 3.008 UBR2
ubiquitin protein ligase E3 component n-recognin 2
chr6_-_22297729 3.006 NM_000948
PRL
prolactin
chr2_-_188419049 3.004 TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr2_+_211458078 3.003 NM_001122634
CPS1
carbamoyl-phosphate synthase 1, mitochondrial
chr11_+_73359734 3.002 NM_001130036
PLEKHB1
pleckstrin homology domain containing, family B (evectins) member 1
chr1_-_161193190 3.001 APOA2
apolipoprotein A-II
chrX_-_8700170 2.971 NM_000216
KAL1
Kallmann syndrome 1 sequence
chr10_+_121485638 2.968 INPP5F
inositol polyphosphate-5-phosphatase F
chrX_-_51239295 2.966 NUDT11
nudix (nucleoside diphosphate linked moiety X)-type motif 11
chr1_+_155829259 2.959 NM_152280
SYT11
synaptotagmin XI
chr2_+_28615695 2.946 FOSL2
FOS-like antigen 2
chr11_+_64851691 2.943 NM_006782
ZFPL1
zinc finger protein-like 1
chr2_+_198365113 2.932 HSPE1
heat shock 10kDa protein 1 (chaperonin 10)
chr2_-_97405775 2.928 LMAN2L
lectin, mannose-binding 2-like
chr1_+_233749749 2.928 NM_002245
KCNK1
potassium channel, subfamily K, member 1
chrX_-_32430370 2.912 NM_004011
NM_004012
DMD

dystrophin

chrX_+_114795176 2.910 NM_005032
PLS3
plastin 3
chr11_-_114466471 2.897 NM_001077639
NM_017678
FAM55D

family with sequence similarity 55, member D

chr8_+_80523048 2.890 NM_001199214
NM_007029
STMN2

stathmin-like 2

chr2_-_224467095 2.871 SCG2
secretogranin II
chr4_-_155533850 2.869 FGG
fibrinogen gamma chain
chr12_+_21679190 2.857 NM_030572
C12orf39
chromosome 12 open reading frame 39
chr10_+_101088794 2.857 NM_020348
CNNM1
cyclin M1
chr6_+_54173202 2.852 NM_014464
TINAG
tubulointerstitial nephritis antigen
chr7_+_130131921 2.852 NM_002402
MEST
mesoderm specific transcript homolog (mouse)
chr4_+_74281884 2.829 ALB
albumin
chr6_-_46459710 2.828 NM_001251973
RCAN2
regulator of calcineurin 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.37 6.64e-18 GO:0032501 multicellular organismal process
1.53 3.55e-15 GO:0048731 system development
1.43 5.09e-15 GO:0032502 developmental process
1.46 6.50e-15 GO:0007275 multicellular organismal development
1.49 8.95e-15 GO:0048856 anatomical structure development
1.74 2.40e-11 GO:0051239 regulation of multicellular organismal process
1.51 1.48e-10 GO:0042221 response to chemical stimulus
1.13 5.47e-10 GO:0009987 cellular process
1.63 1.99e-09 GO:0009653 anatomical structure morphogenesis
1.20 2.12e-09 GO:0065007 biological regulation
1.50 3.48e-09 GO:0048869 cellular developmental process
1.51 4.12e-09 GO:0030154 cell differentiation
1.91 6.14e-09 GO:2000026 regulation of multicellular organismal development
1.49 9.01e-09 GO:0065008 regulation of biological quality
1.23 3.16e-08 GO:0050896 response to stimulus
1.58 5.59e-08 GO:0007399 nervous system development
1.79 7.99e-08 GO:0040011 locomotion
1.74 2.38e-07 GO:0050793 regulation of developmental process
2.28 2.50e-07 GO:0051240 positive regulation of multicellular organismal process
1.32 3.89e-07 GO:0023052 signaling
1.97 3.91e-07 GO:0006928 cellular component movement
1.19 7.86e-07 GO:0050789 regulation of biological process
2.02 1.49e-06 GO:0072358 cardiovascular system development
2.02 1.49e-06 GO:0072359 circulatory system development
1.46 1.86e-06 GO:0048513 organ development
1.37 3.22e-06 GO:0048518 positive regulation of biological process
10.76 1.67e-05 GO:0060678 dichotomous subdivision of terminal units involved in ureteric bud branching
1.65 2.65e-05 GO:0009611 response to wounding
1.72 3.36e-05 GO:0007155 cell adhesion
1.72 3.36e-05 GO:0022610 biological adhesion
1.95 4.58e-05 GO:0051094 positive regulation of developmental process
1.93 5.28e-05 GO:0048870 cell motility
1.93 5.28e-05 GO:0051674 localization of cell
8.81 7.12e-05 GO:0060600 dichotomous subdivision of an epithelial terminal unit
1.25 7.90e-05 GO:0051716 cellular response to stimulus
1.17 1.28e-04 GO:0050794 regulation of cellular process
9.57 1.38e-04 GO:0048880 sensory system development
9.57 1.38e-04 GO:0048892 lateral line nerve development
9.57 1.38e-04 GO:0048895 lateral line nerve glial cell differentiation
9.57 1.38e-04 GO:0048925 lateral line system development
9.57 1.38e-04 GO:0048937 lateral line nerve glial cell development
9.57 1.38e-04 GO:0050935 iridophore differentiation
2.27 1.99e-04 GO:0007507 heart development
1.62 2.43e-04 GO:0009888 tissue development
8.07 2.61e-04 GO:0048846 axon extension involved in axon guidance
1.93 2.73e-04 GO:0016477 cell migration
7.18 2.75e-04 GO:0030513 positive regulation of BMP signaling pathway
7.18 2.75e-04 GO:0048484 enteric nervous system development
1.34 2.80e-04 GO:0048522 positive regulation of cellular process
1.64 2.96e-04 GO:0048584 positive regulation of response to stimulus
1.55 5.65e-04 GO:0007154 cell communication
1.53 6.15e-04 GO:0010646 regulation of cell communication
5.62 6.16e-04 GO:0048588 developmental cell growth
1.27 6.70e-04 GO:0007165 signal transduction
1.63 9.42e-04 GO:0007267 cell-cell signaling
5.00 1.09e-03 GO:0021545 cranial nerve development
1.71 1.64e-03 GO:0042060 wound healing
3.23 2.50e-03 GO:0016049 cell growth
1.55 2.57e-03 GO:0022008 neurogenesis
1.37 3.74e-03 GO:0007166 cell surface receptor linked signaling pathway
1.73 5.06e-03 GO:0006935 chemotaxis
1.73 5.06e-03 GO:0042330 taxis
4.19 5.44e-03 GO:0021675 nerve development
4.78 5.56e-03 GO:0048483 autonomic nervous system development
7.18 5.86e-03 GO:0090184 positive regulation of kidney development
1.54 6.10e-03 GO:0048699 generation of neurons
1.52 6.71e-03 GO:0048468 cell development
1.30 6.87e-03 GO:0048519 negative regulation of biological process
1.71 6.89e-03 GO:0010647 positive regulation of cell communication
1.73 7.94e-03 GO:0019226 transmission of nerve impulse
1.73 7.94e-03 GO:0035637 multicellular organismal signaling
1.34 8.39e-03 GO:0048583 regulation of response to stimulus
1.70 8.75e-03 GO:0023056 positive regulation of signaling
1.65 1.00e-02 GO:0009887 organ morphogenesis
1.29 1.06e-02 GO:0006950 response to stress
1.83 1.07e-02 GO:0060429 epithelium development
3.97 1.16e-02 GO:0014033 neural crest cell differentiation
1.74 1.26e-02 GO:0048646 anatomical structure formation involved in morphogenesis
3.52 1.49e-02 GO:0090100 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
1.75 1.53e-02 GO:0007268 synaptic transmission
4.12 1.59e-02 GO:0014032 neural crest cell development
3.86 1.66e-02 GO:0001667 ameboidal cell migration
4.74 1.71e-02 GO:0001755 neural crest cell migration
1.48 1.84e-02 GO:0032879 regulation of localization
1.22 1.89e-02 GO:0051179 localization
1.36 2.04e-02 GO:0023051 regulation of signaling
10.76 2.11e-02 GO:0032569 gene-specific transcription from RNA polymerase II promoter
1.41 2.75e-02 GO:0009893 positive regulation of metabolic process
1.79 2.89e-02 GO:0090066 regulation of anatomical structure size
1.57 3.05e-02 GO:0010628 positive regulation of gene expression
1.67 3.11e-02 GO:0009967 positive regulation of signal transduction
1.59 3.45e-02 GO:0032989 cellular component morphogenesis
1.71 3.50e-02 GO:0055082 cellular chemical homeostasis
2.92 4.19e-02 GO:0048762 mesenchymal cell differentiation
1.72 4.23e-02 GO:0006873 cellular ion homeostasis
1.89 4.50e-02 GO:0001944 vasculature development
1.60 4.87e-02 GO:0000902 cell morphogenesis

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.90 1.26e-14 GO:0044421 extracellular region part
1.54 1.37e-12 GO:0044459 plasma membrane part
1.89 1.27e-10 GO:0005615 extracellular space
1.67 4.59e-10 GO:0005887 integral to plasma membrane
1.65 1.30e-09 GO:0031226 intrinsic to plasma membrane
1.47 6.43e-09 GO:0005576 extracellular region
1.30 7.36e-09 GO:0071944 cell periphery
1.29 1.87e-08 GO:0005886 plasma membrane
1.95 3.92e-05 GO:0009986 cell surface
1.94 5.77e-05 GO:0031012 extracellular matrix
1.58 1.48e-04 GO:0005626 insoluble fraction
1.57 1.70e-04 GO:0042995 cell projection
1.55 8.33e-04 GO:0005624 membrane fraction
1.80 1.06e-03 GO:0043005 neuron projection
3.44 5.60e-03 GO:0031093 platelet alpha granule lumen
1.41 7.40e-03 GO:0000267 cell fraction
3.36 7.45e-03 GO:0034774 secretory granule lumen
1.79 1.16e-02 GO:0005578 proteinaceous extracellular matrix
3.23 1.28e-02 GO:0060205 cytoplasmic membrane-bounded vesicle lumen
1.99 1.52e-02 GO:0030141 stored secretory granule
3.02 1.75e-02 GO:0031091 platelet alpha granule
3.11 2.14e-02 GO:0031983 vesicle lumen
1.11 3.33e-02 GO:0016020 membrane
2.15 4.33e-02 GO:0034703 cation channel complex

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.17 9.01e-07 GO:0005515 protein binding
1.09 8.28e-06 GO:0005488 binding
1.59 8.44e-06 GO:0005102 receptor binding
2.52 8.70e-03 GO:0019838 growth factor binding
2.31 2.12e-02 GO:0005267 potassium channel activity
2.55 2.33e-02 GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
2.20 2.81e-02 GO:0022843 voltage-gated cation channel activity
2.02 3.29e-02 GO:0005244 voltage-gated ion channel activity
2.02 3.29e-02 GO:0022832 voltage-gated channel activity