Motif ID: IKZF2.p2

Z-value: 1.389


Transcription factors associated with IKZF2.p2:

Gene SymbolEntrez IDGene Name
IKZF2 22807 IKAROS family zinc finger 2 (Helios)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
IKZF2chr2_-_2140163320.261.1e-04Click!


Activity profile for motif IKZF2.p2.

activity profile for motif IKZF2.p2


Sorted Z-values histogram for motif IKZF2.p2

Sorted Z-values for motif IKZF2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of IKZF2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_+_80523376 34.000 STMN2
stathmin-like 2
chr11_-_62472901 25.514


chr1_+_155853546 24.916 SYT11
synaptotagmin XI
chr3_-_195310985 24.246 NM_001647
APOD
apolipoprotein D
chr18_-_74728963 22.298 MBP
myelin basic protein
chr18_-_74729049 22.076 NM_001025081
NM_001025090
NM_001025092
NM_002385
MBP



myelin basic protein



chr4_-_176734181 21.662 NM_201591
GPM6A
glycoprotein M6A
chr7_+_86273219 21.458 NM_000840
GRM3
glutamate receptor, metabotropic 3
chr5_-_42811959 21.057 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chrX_+_103031433 20.696 NM_001128834
PLP1
proteolipid protein 1
chrX_+_103031797 20.470 PLP1
proteolipid protein 1
chr1_-_93399531 20.233


chr3_-_195310770 20.078 APOD
apolipoprotein D
chr3_-_58563070 19.754 FAM107A
family with sequence similarity 107, member A
chrX_+_103031753 19.683 NM_000533
NM_199478
PLP1

proteolipid protein 1

chr4_-_153303663 19.424 NM_001013415
FBXW7
F-box and WD repeat domain containing 7
chrX_+_73164162 18.497 JPX
JPX transcript, XIST activator (non-protein coding)
chr7_-_64023444 17.920


chr5_-_146460991 17.574 NM_181677
NM_181678
PPP2R2B

protein phosphatase 2, regulatory subunit B, beta

chr7_-_137028275 17.511 PTN
pleiotrophin
chr9_-_93405066 17.216 NM_017594
DIRAS2
DIRAS family, GTP-binding RAS-like 2
chr3_-_58563490 16.601 NM_001076778
NM_007177
FAM107A

family with sequence similarity 107, member A

chr4_-_176923572 16.300 NM_005277
NM_201592
GPM6A

glycoprotein M6A

chr7_-_137028433 16.224 PTN
pleiotrophin
chr17_-_29624249 16.211 NM_002544
OMG
oligodendrocyte myelin glycoprotein
chr7_-_137028533 15.955 NM_002825
PTN
pleiotrophin
chr11_+_62475165 15.697 GNG3
guanine nucleotide binding protein (G protein), gamma 3
chr2_-_175712276 14.899 NM_001206602
CHN1
chimerin (chimaerin) 1
chr22_-_38380538 14.144 NM_006941
SOX10
SRY (sex determining region Y)-box 10
chr7_-_137028370 14.093 PTN
pleiotrophin
chr15_+_32933869 13.861 NM_001144757
NM_003020
SCG5

secretogranin V (7B2 protein)

chr6_+_158733691 13.704 NM_001007466
NM_020245
TULP4

tubby like protein 4

chr1_-_57045235 13.489 NM_003713
PPAP2B
phosphatidic acid phosphatase type 2B
chr7_+_64498643 13.418 CCT6P3
chaperonin containing TCP1, subunit 6 (zeta) pseudogene 3
chr4_+_88896868 13.186 SPP1
secreted phosphoprotein 1
chr4_-_153273683 13.117 NM_018315
FBXW7
F-box and WD repeat domain containing 7
chr17_-_66951381 12.656 NM_007168
ABCA8
ATP-binding cassette, sub-family A (ABC1), member 8
chr8_+_24771276 12.500 NEFM
neurofilament, medium polypeptide
chr18_-_53089722 12.492 NM_001243233
TCF4
transcription factor 4
chr18_-_53071225 12.436 NM_001243232
TCF4
transcription factor 4
chr15_+_25101697 12.187 NM_022805
SNRPN
small nuclear ribonucleoprotein polypeptide N
chr1_-_57045214 11.812 PPAP2B
phosphatidic acid phosphatase type 2B
chr5_+_161274196 11.540 NM_000806
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr1_-_163113938 11.484 RGS5
regulator of G-protein signaling 5
chr4_+_154125589 11.462 NM_015271
TRIM2
tripartite motif containing 2
chr8_-_18541441 11.337 PSD3
pleckstrin and Sec7 domain containing 3
chrX_+_135251454 11.200 NM_001159704
FHL1
four and a half LIM domains 1
chr4_+_88896838 10.902 SPP1
secreted phosphoprotein 1
chr7_+_153584383 10.851 NM_001039350
DPP6
dipeptidyl-peptidase 6
chr11_+_62475113 10.830 NM_012202
GNG3
guanine nucleotide binding protein (G protein), gamma 3
chr7_-_99680358 10.820 ZNF3
zinc finger protein 3
chr4_+_113739203 10.790 NM_001127493
ANK2
ankyrin 2, neuronal
chr5_+_173472692 10.754 NM_015980
HMP19
HMP19 protein
chr15_+_43885251 10.751 NM_020990
CKMT1B
CKMT1A
creatine kinase, mitochondrial 1B
creatine kinase, mitochondrial 1A
chr8_+_85095702 10.697 RALYL
RALY RNA binding protein-like
chr8_+_24771268 10.461 NM_005382
NEFM
neurofilament, medium polypeptide
chr8_+_80523351 10.368 STMN2
stathmin-like 2
chr4_+_88896899 10.261 SPP1
secreted phosphoprotein 1
chr3_-_42305438 10.078 NM_001174138
CCK
cholecystokinin
chr3_+_112051914 10.045 NM_001004196
NM_005944
CD200

CD200 molecule

chr10_+_105036783 9.747 NM_032727
INA
internexin neuronal intermediate filament protein, alpha
chr1_-_170038055 9.684 NM_001204517
KIFAP3
kinesin-associated protein 3
chr8_+_80523048 9.669 NM_001199214
NM_007029
STMN2

stathmin-like 2

chr4_-_87281177 9.613 MAPK10
mitogen-activated protein kinase 10
chr20_+_5891973 9.547 NM_001819
CHGB
chromogranin B (secretogranin 1)
chr22_-_38379868 9.404 SOX10
SRY (sex determining region Y)-box 10
chr11_-_65382701 9.266 MAP3K11
mitogen-activated protein kinase kinase kinase 11
chr16_+_81272293 9.229 NM_017429
BCMO1
beta-carotene 15,15'-monooxygenase 1
chr1_+_163038934 9.073 NM_001113381
RGS4
regulator of G-protein signaling 4
chr5_-_151066445 9.070 SPARC
secreted protein, acidic, cysteine-rich (osteonectin)
chr1_+_163038564 9.046 NM_005613
RGS4
regulator of G-protein signaling 4
chr12_-_16759733 9.035 NM_001243610
LMO3
LIM domain only 3 (rhombotin-like 2)
chr8_+_80523339 8.986 STMN2
stathmin-like 2
chr19_+_54926721 8.923 TTYH1
tweety homolog 1 (Drosophila)
chr14_-_21270537 8.890 NM_198232
RNASE1
ribonuclease, RNase A family, 1 (pancreatic)
chr6_+_123100645 8.817 NM_001446
FABP7
fatty acid binding protein 7, brain
chr1_+_159175048 8.816 NM_001122951
DARC
Duffy blood group, chemokine receptor
chr5_-_138211054 8.732 NM_015564
LRRTM2
leucine rich repeat transmembrane neuronal 2
chr8_+_121457642 8.556 NM_022045
MTBP
Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) binding protein, 104kDa
chr4_-_87281374 8.498 NM_138980
NM_138982
MAPK10

mitogen-activated protein kinase 10

chr3_+_238274 8.458 NM_001253387
NM_006614
CHL1

cell adhesion molecule with homology to L1CAM (close homolog of L1)

chr8_+_26435920 8.452 NM_001244604
DPYSL2
dihydropyrimidinase-like 2
chr8_-_82359620 8.425 NM_002677
PMP2
peripheral myelin protein 2
chr12_-_16760935 8.412 NM_001001395
NM_001243609
LMO3

LIM domain only 3 (rhombotin-like 2)

chr11_+_126152979 8.340 NM_001039661
NM_148910
TIRAP

toll-interleukin 1 receptor (TIR) domain containing adaptor protein

chr2_-_127963342 8.318 NM_001001665
CYP27C1
cytochrome P450, family 27, subfamily C, polypeptide 1
chr8_-_22089517 8.210 PHYHIP
phytanoyl-CoA 2-hydroxylase interacting protein
chr8_-_110655418 8.163 NM_001099756
SYBU
syntabulin (syntaxin-interacting)
chr1_+_50569581 8.147 NM_001144776
ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr14_+_100531764 8.126 EVL
Enah/Vasp-like
chr3_-_18480203 8.078 NM_001131010
SATB1
SATB homeobox 1
chrX_+_100333835 8.072 NM_021637
TMEM35
transmembrane protein 35
chr12_-_91573264 8.065 NM_133503
DCN
decorin
chr8_-_27101240 8.063 STMN4
stathmin-like 4
chr18_-_21852189 8.050 NM_018030
OSBPL1A
oxysterol binding protein-like 1A
chr4_+_88896801 8.008 NM_000582
NM_001040058
NM_001040060
NM_001251829
NM_001251830
SPP1




secreted phosphoprotein 1




chr3_+_361365 7.995 NM_001253388
CHL1
cell adhesion molecule with homology to L1CAM (close homolog of L1)
chr14_+_100531745 7.915 NM_016337
EVL
Enah/Vasp-like
chr5_-_43412417 7.870 NM_148672
CCL28
chemokine (C-C motif) ligand 28
chrX_+_102632108 7.818 NM_014380
NGFRAP1
nerve growth factor receptor (TNFRSF16) associated protein 1
chr12_-_16759430 7.810 LMO3
LIM domain only 3 (rhombotin-like 2)
chr3_+_115342302 7.784 GAP43
growth associated protein 43
chr2_+_189839113 7.782 COL3A1
collagen, type III, alpha 1
chr5_-_88179278 7.774 NM_001193350
NM_002397
MEF2C

myocyte enhancer factor 2C

chr18_-_21017816 7.771 NM_032933
TMEM241
transmembrane protein 241
chrX_+_134866213 7.763 NM_001017436
NM_152582
CT45A3
CT45A4
CT45A2
cancer/testis antigen family 45, member A3
cancer/testis antigen family 45, member A4
cancer/testis antigen family 45, member A2
chr2_-_175869910 7.762 NM_001822
NM_001025201
CHN1

chimerin (chimaerin) 1

chr1_+_84647342 7.738 NM_001242862
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr3_+_115342150 7.727 NM_001130064
NM_002045
GAP43

growth associated protein 43

chr2_+_17935124 7.494 NM_182625
GEN1
Gen endonuclease homolog 1 (Drosophila)
chr2_+_189839132 7.442 COL3A1
collagen, type III, alpha 1
chr19_+_54926604 7.395 NM_001005367
NM_001201461
NM_020659
TTYH1


tweety homolog 1 (Drosophila)


chr18_-_53068755 7.333 TCF4
transcription factor 4
chr1_-_230850335 7.318 NM_000029
AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr12_+_101988746 7.251 NM_002465
NM_206819
NM_206820
NM_206821
MYBPC1



myosin binding protein C, slow type



chr1_+_152850797 7.081 NM_030663
SMCP
sperm mitochondria-associated cysteine-rich protein
chr8_+_1952875 7.079 KBTBD11
kelch repeat and BTB (POZ) domain containing 11
chr8_-_37727937 6.992 RAB11FIP1
RAB11 family interacting protein 1 (class I)
chrX_+_110366304 6.919 NM_001128168
NM_001128172
NM_001128173
PAK3


p21 protein (Cdc42/Rac)-activated kinase 3


chr9_-_79520878 6.917 NM_015225
PRUNE2
prune homolog 2 (Drosophila)
chr5_+_140247767 6.910 NM_018902
NM_031861
PCDHA11

protocadherin alpha 11

chr2_+_189839078 6.877 NM_000090
COL3A1
collagen, type III, alpha 1
chr18_-_40695483 6.823 NM_002930
RIT2
Ras-like without CAAX 2
chr15_+_43985083 6.808 NM_001015001
CKMT1A
creatine kinase, mitochondrial 1A
chr10_+_111765725 6.772 NM_019903
ADD3
adducin 3 (gamma)
chr20_-_23402038 6.728 NM_022080
NAPB
N-ethylmaleimide-sensitive factor attachment protein, beta
chr5_+_173472737 6.709 HMP19
HMP19 protein
chr9_-_91793375 6.648 SHC3
SHC (Src homology 2 domain containing) transforming protein 3
chr18_-_52988916 6.643 NM_001243234
NM_001243235
TCF4

transcription factor 4

chr8_+_11141983 6.636 NM_015458
MTMR9
myotubularin related protein 9
chr6_+_27107060 6.586 NM_003495
HIST2H4B
HIST1H4I
histone cluster 2, H4b
histone cluster 1, H4i
chr12_-_16759531 6.545 NM_018640
LMO3
LIM domain only 3 (rhombotin-like 2)
chr16_+_7382750 6.538 NM_145891
NM_145892
NM_145893
RBFOX1


RNA binding protein, fox-1 homolog (C. elegans) 1


chr4_+_71587674 6.538 NM_001037442
NM_014961
RUFY3

RUN and FYVE domain containing 3

chr13_+_97794050 6.482 MBNL2
muscleblind-like 2 (Drosophila)
chr7_+_94024201 6.472 COL1A2
collagen, type I, alpha 2
chr2_+_207406815 6.469 ADAM23
ADAM metallopeptidase domain 23
chr12_-_16759939 6.448 NM_001243613
LMO3
LIM domain only 3 (rhombotin-like 2)
chr5_-_108745569 6.427 NM_014819
PJA2
praja ring finger 2
chr13_+_58205943 6.399 PCDH17
protocadherin 17
chrX_+_135251795 6.378 NM_001167819
FHL1
four and a half LIM domains 1
chr1_-_57045129 6.369 PPAP2B
phosphatidic acid phosphatase type 2B
chr5_-_146435589 6.313 NM_181674
NM_181676
PPP2R2B

protein phosphatase 2, regulatory subunit B, beta

chr18_-_53303129 6.231 NM_001243226
TCF4
transcription factor 4
chr10_-_79789290 6.199 NM_007055
POLR3A
polymerase (RNA) III (DNA directed) polypeptide A, 155kDa
chrX_-_6145887 6.179 NM_020742
NLGN4X
neuroligin 4, X-linked
chr13_+_42846255 6.172 NM_016248
AKAP11
A kinase (PRKA) anchor protein 11
chr7_+_138482696 6.152 NM_001085429
TMEM213
transmembrane protein 213
chr4_+_113970784 6.133 NM_001148
NM_020977
ANK2

ankyrin 2, neuronal

chr8_+_80523304 6.133 STMN2
stathmin-like 2
chr3_+_10068123 6.131 FANCD2
Fanconi anemia, complementation group D2
chr19_+_38893828 6.131 FAM98C
family with sequence similarity 98, member C
chr2_-_2334887 6.106 NM_015025
MYT1L
myelin transcription factor 1-like
chr12_+_175872 6.096 NM_001170738
IQSEC3
IQ motif and Sec7 domain 3
chr12_-_91576579 6.072 DCN
decorin
chr6_-_46825942 6.072 GPR116
G protein-coupled receptor 116
chr6_+_121756744 6.069 NM_000165
GJA1
gap junction protein, alpha 1, 43kDa
chr11_-_62475060 6.051 NM_001122955
BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr5_+_140771482 6.039 NM_014004
NM_032088
PCDHGA8

protocadherin gamma subfamily A, 8

chr3_+_112052020 6.021 CD200
CD200 molecule
chrX_+_135230736 6.018 NM_001159700
FHL1
four and a half LIM domains 1
chr19_-_12662191 5.989 NM_144976
ZNF564
zinc finger protein 564
chrX_-_63005212 5.986 NM_001173479
ARHGEF9
Cdc42 guanine nucleotide exchange factor (GEF) 9
chrX_+_100805415 5.976 NM_016608
ARMCX1
armadillo repeat containing, X-linked 1
chr18_-_21891469 5.925 NM_001242508
OSBPL1A
oxysterol binding protein-like 1A
chr7_+_142560512 5.923 EPHB6
EPH receptor B6
chr11_-_33890931 5.922 LMO2
LIM domain only 2 (rhombotin-like 1)
chr12_-_133532847 5.912 NM_183238
NM_001164715
ZNF605

zinc finger protein 605

chr12_-_15038724 5.892 NM_000900
NM_001190839
MGP

matrix Gla protein

chr3_+_101546833 5.861 NM_001005474
NFKBIZ
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
chr7_+_123565908 5.858 NM_001174045
NM_001174046
SPAM1

sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)

chr1_-_57044980 5.825 PPAP2B
phosphatidic acid phosphatase type 2B
chr12_+_79439432 5.793 NM_001135806
SYT1
synaptotagmin I
chr3_+_10068097 5.688 NM_001018115
NM_033084
FANCD2

Fanconi anemia, complementation group D2

chr16_+_10522724 5.688 NM_024997
ATF7IP2
activating transcription factor 7 interacting protein 2
chr7_-_14880954 5.677 NM_004080
NM_145695
DGKB

diacylglycerol kinase, beta 90kDa

chr1_+_50571963 5.670 NM_001144775
ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr11_-_111782447 5.641 NM_001885
CRYAB
crystallin, alpha B
chr5_-_88199868 5.614 NM_001131005
NM_001193347
MEF2C

myocyte enhancer factor 2C

chr4_+_176987148 5.600 WDR17
WD repeat domain 17
chrX_+_133507299 5.575 NM_001015877
NM_032335
NM_032458
PHF6


PHD finger protein 6


chr14_+_23299083 5.558 NM_178336
NM_180982
NM_181304
NM_181305
NM_181306
NM_181307
MRPL52





mitochondrial ribosomal protein L52





chr4_+_106631966 5.453 NM_001031720
GSTCD
glutathione S-transferase, C-terminal domain containing
chr13_-_73356070 5.445 NM_001128226
NM_014953
DIS3

DIS3 mitotic control homolog (S. cerevisiae)

chrX_-_102941582 5.430 NM_001142418
NM_001142423
NM_001142424
NM_001142425
NM_001142426
NM_001142429
NM_001142430
NM_012286
MORF4L2







mortality factor 4 like 2







chr8_-_102803438 5.348 NM_032041
NCALD
neurocalcin delta
chr1_+_168148215 5.341 TIPRL
TIP41, TOR signaling pathway regulator-like (S. cerevisiae)
chr4_-_174320616 5.337 NM_007281
SCRG1
stimulator of chondrogenesis 1
chr8_+_39442086 5.326 NM_001190956
NM_014237
ADAM18

ADAM metallopeptidase domain 18

chr19_+_41509825 5.259 CYP2B6
cytochrome P450, family 2, subfamily B, polypeptide 6
chrX_+_135278912 5.225 NM_001159701
NM_001159699
FHL1

four and a half LIM domains 1

chr2_-_238322815 5.219 COL6A3
collagen, type VI, alpha 3
chr1_-_203320249 5.218


chr12_-_45269340 5.217 NM_001145109
NELL2
NEL-like 2 (chicken)
chr1_+_84630014 5.200 NM_001242857
NM_001242858
NM_001242859
PRKACB


protein kinase, cAMP-dependent, catalytic, beta


chrX_+_38420690 5.194 NM_004615
TSPAN7
tetraspanin 7
chr9_+_102677457 5.165 STX17
syntaxin 17
chr2_-_238322770 5.150 COL6A3
collagen, type VI, alpha 3
chr3_-_9290592 5.149 SRGAP3
SLIT-ROBO Rho GTPase activating protein 3
chr19_+_21264952 5.139 NM_182515
ZNF714
zinc finger protein 714

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.88 5.34e-09 GO:0007155 cell adhesion
1.88 5.34e-09 GO:0022610 biological adhesion
1.31 3.76e-07 GO:0023052 signaling
1.72 8.88e-07 GO:0040011 locomotion
1.17 1.09e-06 GO:0065007 biological regulation
1.18 2.30e-06 GO:0050789 regulation of biological process
1.18 2.42e-06 GO:0050794 regulation of cellular process
1.20 3.45e-06 GO:0050896 response to stimulus
1.27 3.76e-06 GO:0051716 cellular response to stimulus
1.30 6.27e-06 GO:0007165 signal transduction
1.44 8.68e-06 GO:0007166 cell surface receptor linked signaling pathway
1.65 1.05e-05 GO:0009611 response to wounding
1.22 1.49e-05 GO:0032501 multicellular organismal process
1.10 2.42e-05 GO:0009987 cellular process
1.53 2.59e-05 GO:0002376 immune system process
1.89 3.29e-04 GO:0016477 cell migration
1.29 8.72e-04 GO:0048731 system development
1.35 1.16e-03 GO:0030154 cell differentiation
1.31 1.17e-03 GO:0006950 response to stress
1.79 1.55e-03 GO:0048870 cell motility
1.79 1.55e-03 GO:0051674 localization of cell
1.80 1.80e-03 GO:0050776 regulation of immune response
1.33 2.21e-03 GO:0048869 cellular developmental process
1.70 2.76e-03 GO:0006928 cellular component movement
1.61 3.04e-03 GO:0002682 regulation of immune system process
1.40 4.30e-03 GO:0007399 nervous system development
1.65 5.79e-03 GO:0042060 wound healing
1.55 1.01e-02 GO:0006955 immune response
1.33 1.01e-02 GO:0048583 regulation of response to stimulus
1.69 1.20e-02 GO:0007596 blood coagulation
1.69 1.20e-02 GO:0050817 coagulation
2.29 1.28e-02 GO:0050900 leukocyte migration
1.67 1.44e-02 GO:0006935 chemotaxis
1.67 1.44e-02 GO:0042330 taxis
1.49 1.49e-02 GO:0022008 neurogenesis
1.68 1.54e-02 GO:0007599 hemostasis
1.24 1.58e-02 GO:0048856 anatomical structure development
2.35 1.96e-02 GO:0007156 homophilic cell adhesion
1.71 2.00e-02 GO:0002684 positive regulation of immune system process
1.50 2.84e-02 GO:0006952 defense response
1.28 3.78e-02 GO:0042221 response to chemical stimulus
1.65 3.95e-02 GO:0019226 transmission of nerve impulse
1.65 3.95e-02 GO:0035637 multicellular organismal signaling
1.84 4.56e-02 GO:0016337 cell-cell adhesion

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.40 4.77e-07 GO:0044459 plasma membrane part
1.51 5.63e-06 GO:0031226 intrinsic to plasma membrane
1.51 6.94e-06 GO:0005887 integral to plasma membrane
1.52 7.15e-05 GO:0044421 extracellular region part
1.56 4.08e-04 GO:0005615 extracellular space
1.32 4.28e-04 GO:0005576 extracellular region
1.21 5.73e-04 GO:0005886 plasma membrane
1.20 9.64e-04 GO:0071944 cell periphery
1.71 3.79e-02 GO:0005578 proteinaceous extracellular matrix

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.12 8.17e-03 GO:0005515 protein binding
7.70 1.45e-02 GO:0005132 interferon-alpha/beta receptor binding
1.06 2.11e-02 GO:0005488 binding
5.14 3.64e-02 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity