Motif ID: KLF12.p2

Z-value: 3.542


Transcription factors associated with KLF12.p2:

Gene SymbolEntrez IDGene Name
KLF12 11278 Kruppel-like factor 12

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
KLF12chr13_-_747083610.624.1e-24Click!


Activity profile for motif KLF12.p2.

activity profile for motif KLF12.p2


Sorted Z-values histogram for motif KLF12.p2

Sorted Z-values for motif KLF12.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of KLF12.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_+_139871954 89.293 NM_000954
PTGDS
prostaglandin D2 synthase 21kDa (brain)
chr12_+_79258517 82.728 SYT1
synaptotagmin I
chr12_+_79258588 74.338 SYT1
synaptotagmin I
chr12_+_79258448 68.987 NM_005639
SYT1
synaptotagmin I
chr2_+_203499819 67.296 NM_173511
FAM117B
family with sequence similarity 117, member B
chr7_+_64498643 58.727 CCT6P3
chaperonin containing TCP1, subunit 6 (zeta) pseudogene 3
chr1_+_6845381 52.896 NM_001195563
NM_001242701
NM_015215
CAMTA1


calmodulin binding transcription activator 1


chr21_-_48024985 50.461 NM_006272
S100B
S100 calcium binding protein B
chr9_+_139872014 50.002 PTGDS
prostaglandin D2 synthase 21kDa (brain)
chr10_-_32636134 49.588 EPC1
enhancer of polycomb homolog 1 (Drosophila)
chr5_+_175792444 48.829 NM_173664
ARL10
ADP-ribosylation factor-like 10
chr17_+_1665342 48.635 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr17_+_1665281 47.628 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr17_+_1665306 47.019 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr9_-_133454818 44.648 LOC100272217
uncharacterized LOC100272217
chr5_+_137801166 43.910 EGR1
early growth response 1
chr11_+_62475165 43.431 GNG3
guanine nucleotide binding protein (G protein), gamma 3
chr17_+_38119225 43.062 NM_178171
GSDMA
gasdermin A
chr8_-_27115935 42.977 STMN4
stathmin-like 4
chr5_+_137801178 42.681 NM_001964
EGR1
early growth response 1
chr15_+_84115979 41.014 NM_003027
SH3GL3
SH3-domain GRB2-like 3
chr16_+_67198678 39.057 HSF4
heat shock transcription factor 4
chr8_+_80523339 39.033 STMN2
stathmin-like 2
chr8_+_80523376 39.011 STMN2
stathmin-like 2
chr8_+_80523351 38.747 STMN2
stathmin-like 2
chr16_-_31085073 37.451 ZNF668
zinc finger protein 668
chr1_+_159175048 37.211 NM_001122951
DARC
Duffy blood group, chemokine receptor
chr8_+_80523304 37.191 STMN2
stathmin-like 2
chr18_-_74691951 35.827 MBP
myelin basic protein
chr17_+_1665233 35.026 NM_002615
SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr14_-_23821423 34.097 NM_020372
SLC22A17
solute carrier family 22, member 17
chr20_+_34742656 32.056 NM_012156
EPB41L1
erythrocyte membrane protein band 4.1-like 1
chr1_+_151254740 31.850 NM_020832
ZNF687
zinc finger protein 687
chr11_+_62475113 31.517 NM_012202
GNG3
guanine nucleotide binding protein (G protein), gamma 3
chr17_-_7197811 30.890 YBX2
Y box binding protein 2
chr10_+_124220990 30.604 NM_002775
HTRA1
HtrA serine peptidase 1
chr1_-_38512446 30.493 NM_002699
POU3F1
POU class 3 homeobox 1
chr10_-_118501981 29.955 NM_025015
HSPA12A
heat shock 70kDa protein 12A
chr12_+_79258794 29.748 SYT1
synaptotagmin I
chr16_+_67198637 29.525 HSF4
heat shock transcription factor 4
chr7_+_100136845 29.219 AGFG2
ArfGAP with FG repeats 2
chr6_+_99872769 29.090


chr11_-_125366048 29.055 NM_005103
NM_022549
FEZ1

fasciculation and elongation protein zeta 1 (zygin I)

chr3_-_9439122 28.825 LOC440944
uncharacterized LOC440944
chr1_-_182360400 28.534 NM_001033056
GLUL
glutamate-ammonia ligase
chr16_+_222845 27.945 NM_000517
HBA1
HBA2
hemoglobin, alpha 1
hemoglobin, alpha 2
chr11_+_117070039 27.767 NM_001001522
NM_003186
TAGLN

transgelin

chr7_-_75368216 26.844 HIP1
huntingtin interacting protein 1
chr4_-_176733413 26.613 GPM6A
glycoprotein M6A
chr8_-_82359620 26.507 NM_002677
PMP2
peripheral myelin protein 2
chr17_-_7197866 26.228 NM_015982
YBX2
Y box binding protein 2
chr1_-_46598250 26.185 NM_003629
NM_001114172
PIK3R3

phosphoinositide-3-kinase, regulatory subunit 3 (gamma)

chr2_-_74709965 25.825 CCDC142
coiled-coil domain containing 142
chr1_+_2005083 25.611 NM_001033581
PRKCZ
protein kinase C, zeta
chr14_-_103988829 25.520 CKB
creatine kinase, brain
chr1_+_171810611 25.303 NM_001136127
NM_015569
DNM3

dynamin 3

chr1_-_182360181 25.197 GLUL
glutamate-ammonia ligase
chr20_-_3154169 25.187 ProSAPiP1
ProSAPiP1 protein
chrX_-_70288155 25.014 NM_013346
SNX12
sorting nexin 12
chr6_-_46459710 24.937 NM_001251973
RCAN2
regulator of calcineurin 2
chr16_-_2264776 24.724 NM_001042371
PGP
phosphoglycolate phosphatase
chr19_+_35630391 24.689 NM_005031
FXYD1
FXYD domain containing ion transport regulator 1
chr16_-_31085503 24.454 NM_024706
ZNF668
zinc finger protein 668
chr4_-_57522469 24.040 NM_001145459
NM_139211
HOPX

HOP homeobox

chr11_+_61197574 24.008 NM_017841
SDHAF2
succinate dehydrogenase complex assembly factor 2
chr3_+_15469052 23.889 NM_033083
EAF1
ELL associated factor 1
chr6_-_111136616 23.882 CDK19
cyclin-dependent kinase 19
chrX_-_13835313 23.869 NM_001001995
NM_001001996
NM_005278
GPM6B


glycoprotein M6B


chr14_-_106610338 23.854 IGHV4-31
IGHG1
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant gamma 1 (G1m marker)
chr8_-_80679897 23.819 NM_001040708
NM_012258
HEY1

hairy/enhancer-of-split related with YRPW motif 1

chr11_+_124609841 23.576 NRGN
neurogranin (protein kinase C substrate, RC3)
chr8_-_24814028 23.540 NM_006158
NEFL
neurofilament, light polypeptide
chr13_+_58207858 23.535 PCDH17
protocadherin 17
chr7_+_142552547 23.335 NM_004445
EPHB6
EPH receptor B6
chr5_-_149535138 23.323 PDGFRB
platelet-derived growth factor receptor, beta polypeptide
chrX_+_68048792 23.176 NM_004429
EFNB1
ephrin-B1
chr17_+_26699093 23.106 SARM1
sterile alpha and TIR motif containing 1
chr3_+_115342150 23.042 NM_001130064
NM_002045
GAP43

growth associated protein 43

chr16_-_3930713 22.744 CREBBP
CREB binding protein
chr1_-_203055088 22.591 MYOG
myogenin (myogenic factor 4)
chr14_-_23834417 22.537 EFS
embryonal Fyn-associated substrate
chr4_-_176733901 22.497 GPM6A
glycoprotein M6A
chr17_-_7197896 22.324 YBX2
Y box binding protein 2
chr8_-_27115897 22.273 NM_030795
STMN4
stathmin-like 4
chr3_+_50306305 22.165 SEMA3B
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
chr5_-_42811959 22.077 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr3_+_238535 21.885 CHL1
cell adhesion molecule with homology to L1CAM (close homolog of L1)
chr19_-_55866063 21.654 NM_144613
COX6B2
cytochrome c oxidase subunit VIb polypeptide 2 (testis)
chr15_-_83349134 21.545 AP3B2
adaptor-related protein complex 3, beta 2 subunit
chr16_-_49315682 21.544 NM_004352
CBLN1
cerebellin 1 precursor
chr12_+_79439432 21.257 NM_001135806
SYT1
synaptotagmin I
chr12_-_3982394 21.154 NM_020367
PARP11
poly (ADP-ribose) polymerase family, member 11
chr16_-_30934437 21.111 FBXL19-AS1
FBXL19 antisense RNA 1 (non-protein coding)
chr10_-_119301750 20.939 EMX2OS
EMX2 opposite strand/antisense RNA (non-protein coding)
chr17_-_74449272 20.936 NM_022066
UBE2O
ubiquitin-conjugating enzyme E2O
chr17_+_48172508 20.824 NM_001199900
NM_002611
NM_001199899
PDK2


pyruvate dehydrogenase kinase, isozyme 2


chr15_-_76030958 20.815 DNM1P35
DNM1 pseudogene 35
chr17_-_74449220 20.732 UBE2O
ubiquitin-conjugating enzyme E2O
chr17_+_17942584 20.595 NM_024052
C17orf39
chromosome 17 open reading frame 39
chrX_-_13835012 20.420 GPM6B
glycoprotein M6B
chr1_-_223537400 20.349 NM_001037175
NM_017982
SUSD4

sushi domain containing 4

chr1_+_22963097 20.337 NM_015991
C1QA
complement component 1, q subcomponent, A chain
chr15_-_65360297 20.223 NM_016563
RASL12
RAS-like, family 12
chr22_+_22735207 20.123 IGLJ3
immunoglobulin lambda joining 3
chr11_+_113930296 20.109 ZBTB16
zinc finger and BTB domain containing 16
chr5_+_31639424 20.062 PDZD2
PDZ domain containing 2
chr17_+_7554239 19.856 NM_001678
ATP1B2
ATPase, Na+/K+ transporting, beta 2 polypeptide
chr6_+_7108864 19.694 RREB1
ras responsive element binding protein 1
chr11_-_66725790 19.564 NM_000920
NM_001040716
PC

pyruvate carboxylase

chr16_+_15528324 19.500 NM_033201
C16orf45
chromosome 16 open reading frame 45
chr7_+_65338161 19.467 NM_173517
VKORC1L1
vitamin K epoxide reductase complex, subunit 1-like 1
chr1_-_114354906 19.429 NM_018364
RSBN1
round spermatid basic protein 1
chr12_+_53817638 19.348 NM_001164690
NM_001164691
NM_020547
AMHR2


anti-Mullerian hormone receptor, type II


chr19_+_50270263 19.337 AP2A1
adaptor-related protein complex 2, alpha 1 subunit
chr19_-_58427934 19.333 NM_152475
ZNF417
zinc finger protein 417
chr11_+_113930430 19.253 NM_006006
ZBTB16
zinc finger and BTB domain containing 16
chr17_+_28256873 19.226 NM_001145053
EFCAB5
EF-hand calcium binding domain 5
chr19_+_42829760 19.163 NM_001410
MEGF8
multiple EGF-like-domains 8
chr5_+_140810326 19.085 PCDHGA12
protocadherin gamma subfamily A, 12
chr3_+_115342302 19.016 GAP43
growth associated protein 43
chr5_+_140810181 18.937 PCDHGA12
protocadherin gamma subfamily A, 12
chr2_-_172864747 18.908


chr17_-_1548992 18.844 NM_003693
NM_145350
NM_145352
SCARF1


scavenger receptor class F, member 1


chr20_-_3149070 18.771 NM_014731
ProSAPiP1
ProSAPiP1 protein
chrX_-_47479229 18.733 NM_006950
NM_133499
SYN1

synapsin I

chr17_-_17942326 18.568 NM_145691
ATPAF2
ATP synthase mitochondrial F1 complex assembly factor 2
chr5_-_142065991 18.482 NM_033136
FGF1
fibroblast growth factor 1 (acidic)
chr3_-_10749715 18.365 ATP2B2
ATPase, Ca++ transporting, plasma membrane 2
chr9_+_35538628 18.260 NM_001135999
RUSC2
RUN and SH3 domain containing 2
chr3_-_13008959 18.227 NM_014869
IQSEC1
IQ motif and Sec7 domain 1
chr7_+_98246595 18.195 NM_002523
NPTX2
neuronal pentraxin II
chr7_+_100136784 18.180 NM_006076
AGFG2
ArfGAP with FG repeats 2
chr4_+_72102249 18.173 SLC4A4
solute carrier family 4, sodium bicarbonate cotransporter, member 4
chr11_-_133402227 18.131 NM_001012393
OPCML
opioid binding protein/cell adhesion molecule-like
chr9_-_139907614 18.128 ABCA2
ATP-binding cassette, sub-family A (ABC1), member 2
chr1_-_203055376 18.107 NM_002479
MYOG
myogenin (myogenic factor 4)
chr14_+_45431333 17.983 NM_015091
FAM179B
family with sequence similarity 179, member B
chr13_-_67804432 17.974 NM_020403
NM_203487
PCDH9

protocadherin 9

chr18_-_74729049 17.973 NM_001025081
NM_001025090
NM_001025092
NM_002385
MBP



myelin basic protein



chr6_+_31126114 17.921 NM_001077511
NM_007109
TCF19

transcription factor 19

chr16_-_70713927 17.911 MTSS1L
metastasis suppressor 1-like
chr17_+_29421956 17.835 NF1
neurofibromin 1
chr7_+_86273951 17.801 GRM3
glutamate receptor, metabotropic 3
chr2_+_24272627 17.775 FKBP1B
FK506 binding protein 1B, 12.6 kDa
chr11_+_121461070 17.718 SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr12_+_122064448 17.693 NM_032790
ORAI1
ORAI calcium release-activated calcium modulator 1
chr5_+_149737296 17.570 TCOF1
Treacher Collins-Franceschetti syndrome 1
chr10_+_64133915 17.550 NM_014951
NM_199450
NM_199451
ZNF365


zinc finger protein 365


chr22_-_19512859 17.541 NM_001130861
NM_003277
CLDN5

claudin 5

chr2_+_220042986 17.427 FAM134A
family with sequence similarity 134, member A
chr7_-_143059696 17.421 NM_001031690
FAM131B
family with sequence similarity 131, member B
chr3_+_23987514 17.377 NM_001145425
NR1D2
nuclear receptor subfamily 1, group D, member 2
chr15_-_90347173 17.370 ANPEP
alanyl (membrane) aminopeptidase
chr17_-_78450247 17.362 NM_002522
NPTX1
neuronal pentraxin I
chr5_-_149792370 17.355 NM_001025158
NM_001025159
NM_004355
CD74


CD74 molecule, major histocompatibility complex, class II invariant chain


chr19_-_47164289 17.304 NM_145056
DACT3
dapper, antagonist of beta-catenin, homolog 3 (Xenopus laevis)
chr7_-_31380507 17.277 NM_022728
NEUROD6
neurogenic differentiation 6
chr10_+_75532252 17.243 FUT11
fucosyltransferase 11 (alpha (1,3) fucosyltransferase)
chr16_-_31084822 17.240 NM_001172668
ZNF668
zinc finger protein 668
chr15_+_64443909 17.177 NM_024798
SNX22
sorting nexin 22
chr18_-_74728963 17.127 MBP
myelin basic protein
chr5_-_95297424 17.104 ELL2
elongation factor, RNA polymerase II, 2
chr3_-_169899372 17.099 PHC3
polyhomeotic homolog 3 (Drosophila)
chr19_+_50380681 17.034 NM_001168222
NM_024682
TBC1D17

TBC1 domain family, member 17

chr11_-_132812870 16.985 NM_002545
OPCML
opioid binding protein/cell adhesion molecule-like
chr8_+_141521365 16.962 NM_017444
CHRAC1
chromatin accessibility complex 1
chr4_+_166299942 16.871 NM_001873
CPE
carboxypeptidase E
chr3_+_50306578 16.704 SEMA3B
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
chr16_+_28834407 16.691 NM_007245
NM_145714
NM_148414
NM_148415
NM_148416
ATXN2L




ataxin 2-like




chr11_-_62476976 16.689 BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr6_+_36238236 16.569 NM_001145717
PNPLA1
patatin-like phospholipase domain containing 1
chr6_+_31554475 16.548 NM_205837
LST1
leukocyte specific transcript 1
chr14_-_23834841 16.519 NM_005864
NM_032459
EFS

embryonal Fyn-associated substrate

chr8_+_22462532 16.492 NM_021174
KIAA1967
KIAA1967
chr19_+_50353942 16.479 PTOV1
prostate tumor overexpressed 1
chr10_+_75545363 16.459 NM_001242487
NM_001242488
NM_015037
KIAA0913


KIAA0913


chr15_+_84116172 16.381 SH3GL3
SH3-domain GRB2-like 3
chr2_+_24272583 16.355 NM_004116
NM_054033
FKBP1B

FK506 binding protein 1B, 12.6 kDa

chrX_-_107979606 16.344 NM_003604
IRS4
insulin receptor substrate 4
chr16_+_28834565 16.304 ATXN2L
ataxin 2-like
chr6_-_166796363 16.272 BRP44L
brain protein 44-like
chr19_+_45409003 16.266 NM_000041
APOE
apolipoprotein E
chr9_-_96717544 16.261 NM_021570
BARX1
BARX homeobox 1
chr8_-_132052834 16.238 NM_001115
ADCY8
adenylate cyclase 8 (brain)
chr2_-_220173693 16.203 NM_001199764
PTPRN
protein tyrosine phosphatase, receptor type, N
chr2_-_224467049 16.160 SCG2
secretogranin II
chr2_-_73520448 16.122 NM_001965
EGR4
early growth response 4
chr9_-_91793375 16.116 SHC3
SHC (Src homology 2 domain containing) transforming protein 3
chr2_+_128643535 16.114


chr15_-_75165595 16.089 NM_005697
SCAMP2
secretory carrier membrane protein 2
chr14_-_51562421 16.065 NM_015163
NM_052978
TRIM9

tripartite motif containing 9

chr3_-_15468981 16.061 NM_152396
METTL6
methyltransferase like 6
chr2_-_73053030 16.046 NM_015189
EXOC6B
exocyst complex component 6B
chr2_-_175712276 16.043 NM_001206602
CHN1
chimerin (chimaerin) 1
chr16_+_28834360 16.040 ATXN2L
ataxin 2-like
chr8_+_1952875 15.948 KBTBD11
kelch repeat and BTB (POZ) domain containing 11
chr17_+_7554711 15.861 ATP1B2
ATPase, Na+/K+ transporting, beta 2 polypeptide
chr5_-_149792276 15.849 CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chr6_+_19837599 15.789 NM_001546
ID4
inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
chr6_-_31763415 15.780 VARS
valyl-tRNA synthetase

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.38 1.24e-31 GO:0023052 signaling
1.22 5.89e-31 GO:0065007 biological regulation
1.13 3.02e-27 GO:0009987 cellular process
1.38 5.55e-27 GO:0007275 multicellular organismal development
1.42 1.12e-26 GO:0048731 system development
1.21 1.77e-26 GO:0050789 regulation of biological process
1.35 6.15e-26 GO:0032502 developmental process
1.27 1.72e-25 GO:0032501 multicellular organismal process
1.22 1.90e-25 GO:0050794 regulation of cellular process
1.38 9.42e-25 GO:0048856 anatomical structure development
1.34 3.61e-21 GO:0007165 signal transduction
1.55 1.54e-20 GO:0007399 nervous system development
1.75 2.51e-18 GO:0007267 cell-cell signaling
1.63 1.05e-17 GO:0007154 cell communication
1.42 4.46e-15 GO:0007166 cell surface receptor linked signaling pathway
1.25 2.14e-14 GO:0051716 cellular response to stimulus
1.37 6.72e-14 GO:0048869 cellular developmental process
1.45 6.85e-14 GO:0009653 anatomical structure morphogenesis
1.37 2.51e-13 GO:0030154 cell differentiation
1.81 3.64e-13 GO:0019226 transmission of nerve impulse
1.81 3.64e-13 GO:0035637 multicellular organismal signaling
1.48 4.73e-13 GO:0051239 regulation of multicellular organismal process
1.38 9.41e-13 GO:0048513 organ development
1.35 1.41e-12 GO:0065008 regulation of biological quality
1.57 1.81e-12 GO:0022008 neurogenesis
1.30 3.65e-12 GO:0048518 positive regulation of biological process
1.64 1.38e-11 GO:0030182 neuron differentiation
1.56 2.89e-11 GO:0040011 locomotion
1.35 1.38e-10 GO:0048583 regulation of response to stimulus
1.54 1.40e-10 GO:0048699 generation of neurons
1.16 3.17e-10 GO:0050896 response to stimulus
1.72 3.28e-10 GO:0048858 cell projection morphogenesis
1.77 3.62e-10 GO:0007268 synaptic transmission
1.37 4.09e-10 GO:0023051 regulation of signaling
1.70 7.26e-10 GO:0006935 chemotaxis
1.70 7.26e-10 GO:0042330 taxis
1.70 7.71e-10 GO:0032990 cell part morphogenesis
1.77 8.72e-10 GO:0007409 axonogenesis
1.65 1.68e-09 GO:0048666 neuron development
1.74 1.78e-09 GO:0048812 neuron projection morphogenesis
1.75 1.85e-09 GO:0048667 cell morphogenesis involved in neuron differentiation
1.59 3.30e-09 GO:0010628 positive regulation of gene expression
1.69 3.76e-09 GO:0000904 cell morphogenesis involved in differentiation
1.60 3.98e-09 GO:0030030 cell projection organization
1.62 4.43e-09 GO:0000902 cell morphogenesis
1.47 5.33e-09 GO:0009605 response to external stimulus
1.68 6.06e-09 GO:0031175 neuron projection development
1.60 7.21e-09 GO:0032989 cellular component morphogenesis
1.83 9.77e-09 GO:0007411 axon guidance
1.50 1.03e-08 GO:0006351 transcription, DNA-dependent
1.29 1.17e-08 GO:0042221 response to chemical stimulus
1.28 1.22e-08 GO:0048522 positive regulation of cellular process
1.48 1.49e-08 GO:0048468 cell development
1.47 2.98e-08 GO:0050793 regulation of developmental process
1.67 3.53e-08 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.59 5.82e-08 GO:0009887 organ morphogenesis
1.27 6.14e-08 GO:0048519 negative regulation of biological process
1.43 6.80e-08 GO:0010646 regulation of cell communication
1.44 1.56e-07 GO:0032879 regulation of localization
1.50 1.84e-07 GO:0007155 cell adhesion
1.50 1.84e-07 GO:0022610 biological adhesion
1.25 2.11e-07 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.50 2.41e-07 GO:2000026 regulation of multicellular organismal development
1.61 3.17e-07 GO:0007417 central nervous system development
1.28 3.72e-07 GO:0048523 negative regulation of cellular process
1.43 3.88e-07 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.21 4.03e-07 GO:0051179 localization
1.52 5.28e-07 GO:0045595 regulation of cell differentiation
1.35 6.49e-07 GO:0009966 regulation of signal transduction
1.48 7.04e-07 GO:0051173 positive regulation of nitrogen compound metabolic process
1.43 8.48e-07 GO:0042127 regulation of cell proliferation
1.54 8.69e-07 GO:0045893 positive regulation of transcription, DNA-dependent
1.48 1.03e-06 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.20 2.31e-06 GO:0080090 regulation of primary metabolic process
1.23 2.69e-06 GO:0051171 regulation of nitrogen compound metabolic process
1.44 3.27e-06 GO:0031328 positive regulation of cellular biosynthetic process
1.44 3.72e-06 GO:0009891 positive regulation of biosynthetic process
1.50 3.98e-06 GO:0051254 positive regulation of RNA metabolic process
1.71 5.04e-06 GO:0044057 regulation of system process
1.47 5.32e-06 GO:0010557 positive regulation of macromolecule biosynthetic process
1.23 5.84e-06 GO:0031326 regulation of cellular biosynthetic process
1.22 6.09e-06 GO:0009889 regulation of biosynthetic process
1.18 6.62e-06 GO:0019222 regulation of metabolic process
1.19 9.25e-06 GO:0031323 regulation of cellular metabolic process
1.44 1.06e-05 GO:0048584 positive regulation of response to stimulus
1.83 1.10e-05 GO:0030168 platelet activation
1.53 1.52e-05 GO:0007186 G-protein coupled receptor protein signaling pathway
2.11 1.97e-05 GO:0048705 skeletal system morphogenesis
1.65 1.98e-05 GO:0007420 brain development
1.55 2.15e-05 GO:0001775 cell activation
1.32 2.40e-05 GO:0035556 intracellular signal transduction
1.45 2.63e-05 GO:0051049 regulation of transport
1.58 4.20e-05 GO:0032583 regulation of gene-specific transcription
1.33 4.92e-05 GO:0009893 positive regulation of metabolic process
1.38 5.10e-05 GO:0032774 RNA biosynthetic process
1.20 8.13e-05 GO:0006810 transport
1.47 1.05e-04 GO:0048878 chemical homeostasis
1.46 1.09e-04 GO:0007167 enzyme linked receptor protein signaling pathway
1.23 1.20e-04 GO:0006355 regulation of transcription, DNA-dependent
1.21 1.23e-04 GO:0010468 regulation of gene expression
1.33 1.55e-04 GO:0010604 positive regulation of macromolecule metabolic process
1.68 1.83e-04 GO:0001944 vasculature development
1.19 1.87e-04 GO:0051234 establishment of localization
1.53 2.18e-04 GO:0072358 cardiovascular system development
1.53 2.18e-04 GO:0072359 circulatory system development
1.22 2.49e-04 GO:0051252 regulation of RNA metabolic process
1.18 2.59e-04 GO:0060255 regulation of macromolecule metabolic process
1.63 3.01e-04 GO:0051093 negative regulation of developmental process
1.37 3.02e-04 GO:0009611 response to wounding
1.45 3.52e-04 GO:0051172 negative regulation of nitrogen compound metabolic process
1.53 4.79e-04 GO:0051094 positive regulation of developmental process
1.47 4.85e-04 GO:0051253 negative regulation of RNA metabolic process
1.42 5.15e-04 GO:0031327 negative regulation of cellular biosynthetic process
1.41 5.76e-04 GO:0009890 negative regulation of biosynthetic process
1.54 6.39e-04 GO:0016477 cell migration
2.11 6.73e-04 GO:0051924 regulation of calcium ion transport
1.68 7.04e-04 GO:0001568 blood vessel development
1.81 1.06e-03 GO:0003012 muscle system process
1.47 1.09e-03 GO:0045892 negative regulation of transcription, DNA-dependent
1.43 1.13e-03 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.20 1.21e-03 GO:0010556 regulation of macromolecule biosynthetic process
1.64 1.26e-03 GO:0007423 sensory organ development
1.48 1.35e-03 GO:0048585 negative regulation of response to stimulus
1.58 1.39e-03 GO:0007389 pattern specification process
1.98 1.64e-03 GO:0010959 regulation of metal ion transport
1.60 1.86e-03 GO:0001501 skeletal system development
1.51 2.22e-03 GO:0008285 negative regulation of cell proliferation
1.40 2.26e-03 GO:0009719 response to endogenous stimulus
1.60 2.34e-03 GO:0022603 regulation of anatomical structure morphogenesis
1.57 2.48e-03 GO:0045597 positive regulation of cell differentiation
1.29 2.53e-03 GO:0031325 positive regulation of cellular metabolic process
1.87 2.69e-03 GO:0034330 cell junction organization
1.87 2.69e-03 GO:0043269 regulation of ion transport
1.35 2.75e-03 GO:0009888 tissue development
1.49 2.77e-03 GO:0055082 cellular chemical homeostasis
1.54 3.07e-03 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
1.48 3.27e-03 GO:0048870 cell motility
1.48 3.27e-03 GO:0051674 localization of cell
1.50 3.52e-03 GO:0006873 cellular ion homeostasis
1.44 3.61e-03 GO:0006928 cellular component movement
3.43 3.99e-03 GO:0071396 cellular response to lipid
1.47 4.41e-03 GO:0050801 ion homeostasis
1.19 4.72e-03 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.69 5.22e-03 GO:0048514 blood vessel morphogenesis
1.39 5.36e-03 GO:0010558 negative regulation of macromolecule biosynthetic process
1.63 5.75e-03 GO:0045596 negative regulation of cell differentiation
1.28 5.90e-03 GO:0002376 immune system process
1.89 6.24e-03 GO:0034329 cell junction assembly
1.59 6.32e-03 GO:0040012 regulation of locomotion
1.57 6.42e-03 GO:0006140 regulation of nucleotide metabolic process
1.44 6.85e-03 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.47 7.28e-03 GO:0010648 negative regulation of cell communication
1.82 7.59e-03 GO:0019935 cyclic-nucleotide-mediated signaling
2.50 7.61e-03 GO:0033993 response to lipid
2.45 8.05e-03 GO:0060348 bone development
1.40 8.19e-03 GO:0009725 response to hormone stimulus
2.36 8.51e-03 GO:0034339 regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor
1.86 9.50e-03 GO:0007187 G-protein signaling, coupled to cyclic nucleotide second messenger
1.64 1.01e-02 GO:0003002 regionalization
1.40 1.07e-02 GO:0042060 wound healing
1.55 1.09e-02 GO:0060284 regulation of cell development
1.47 1.10e-02 GO:0023057 negative regulation of signaling
1.39 1.14e-02 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.26 1.21e-02 GO:0010033 response to organic substance
1.22 1.22e-02 GO:0003008 system process
2.74 1.26e-02 GO:0003014 renal system process
1.55 1.29e-02 GO:0051046 regulation of secretion
1.76 1.36e-02 GO:0006936 muscle contraction
1.47 1.41e-02 GO:0060341 regulation of cellular localization
1.57 1.45e-02 GO:0051270 regulation of cellular component movement
2.65 1.48e-02 GO:0060349 bone morphogenesis
2.16 1.73e-02 GO:0010721 negative regulation of cell development
1.40 2.01e-02 GO:0050878 regulation of body fluid levels
1.79 2.03e-02 GO:0032844 regulation of homeostatic process
1.38 2.13e-02 GO:0010629 negative regulation of gene expression
1.31 2.40e-02 GO:0042592 homeostatic process
1.44 2.47e-02 GO:0048646 anatomical structure formation involved in morphogenesis
1.46 2.70e-02 GO:0009968 negative regulation of signal transduction
1.93 2.94e-02 GO:0001822 kidney development
1.83 2.95e-02 GO:0030111 regulation of Wnt receptor signaling pathway
1.44 3.18e-02 GO:0046903 secretion
1.55 3.23e-02 GO:0030029 actin filament-based process
1.56 3.49e-02 GO:0035295 tube development
1.95 3.63e-02 GO:0045761 regulation of adenylate cyclase activity
1.53 3.98e-02 GO:0016337 cell-cell adhesion
1.57 4.29e-02 GO:2000145 regulation of cell motility
1.23 4.35e-02 GO:0065009 regulation of molecular function
1.52 4.86e-02 GO:0007610 behavior
1.39 4.91e-02 GO:0010647 positive regulation of cell communication
1.57 4.92e-02 GO:0030334 regulation of cell migration
1.30 4.94e-02 GO:0006811 ion transport

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.44 3.14e-23 GO:0044459 plasma membrane part
1.53 6.44e-17 GO:0005887 integral to plasma membrane
1.52 9.49e-17 GO:0031226 intrinsic to plasma membrane
1.21 8.18e-12 GO:0071944 cell periphery
1.21 2.65e-11 GO:0005886 plasma membrane
1.47 1.35e-08 GO:0005626 insoluble fraction
1.68 4.17e-08 GO:0043005 neuron projection
1.66 1.13e-07 GO:0045202 synapse
1.38 1.18e-07 GO:0000267 cell fraction
1.44 2.98e-07 GO:0005624 membrane fraction
1.91 4.40e-06 GO:0030424 axon
1.65 3.44e-05 GO:0044456 synapse part
2.27 1.30e-04 GO:0033267 axon part
1.35 1.51e-04 GO:0042995 cell projection
1.76 2.25e-04 GO:0030425 dendrite
1.40 8.52e-04 GO:0030054 cell junction
2.11 1.28e-03 GO:0030139 endocytic vesicle
2.64 1.30e-03 GO:0043679 axon terminus
1.70 3.29e-03 GO:0044297 cell body
2.52 3.81e-03 GO:0044306 neuron projection terminus
1.44 6.31e-03 GO:0044463 cell projection part
1.48 1.10e-02 GO:0044433 cytoplasmic vesicle part
1.67 1.12e-02 GO:0043025 neuronal cell body
1.59 1.30e-02 GO:0034702 ion channel complex
1.51 1.68e-02 GO:0012506 vesicle membrane
1.29 1.83e-02 GO:0031982 vesicle
1.29 2.98e-02 GO:0031410 cytoplasmic vesicle
2.65 3.08e-02 GO:0034704 calcium channel complex
1.71 3.25e-02 GO:0034703 cation channel complex
1.49 4.47e-02 GO:0030659 cytoplasmic vesicle membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.09 1.77e-16 GO:0005488 binding
1.56 1.96e-14 GO:0001071 nucleic acid binding transcription factor activity
1.56 1.96e-14 GO:0003700 sequence-specific DNA binding transcription factor activity
1.15 5.92e-14 GO:0005515 protein binding
1.62 7.31e-12 GO:0043565 sequence-specific DNA binding
1.34 8.96e-05 GO:0030528 transcription regulator activity
1.41 2.18e-04 GO:0046983 protein dimerization activity
1.52 2.89e-04 GO:0015267 channel activity
1.51 3.36e-04 GO:0022803 passive transmembrane transporter activity
2.25 3.75e-04 GO:0005262 calcium channel activity
1.64 3.96e-04 GO:0005261 cation channel activity
2.54 4.95e-04 GO:0003707 steroid hormone receptor activity
2.49 5.34e-04 GO:0004879 ligand-dependent nuclear receptor activity
1.58 7.11e-04 GO:0022836 gated channel activity
1.87 1.02e-03 GO:0005516 calmodulin binding
1.30 1.20e-03 GO:0005102 receptor binding
1.49 2.05e-03 GO:0005216 ion channel activity
1.48 2.75e-03 GO:0022838 substrate-specific channel activity
1.45 4.31e-03 GO:0042803 protein homodimerization activity
1.79 5.26e-03 GO:0022843 voltage-gated cation channel activity
1.33 7.36e-03 GO:0042802 identical protein binding
1.31 2.23e-02 GO:0019899 enzyme binding
1.39 2.39e-02 GO:0060589 nucleoside-triphosphatase regulator activity
1.40 2.44e-02 GO:0030695 GTPase regulator activity
1.18 2.49e-02 GO:0004871 signal transducer activity
1.18 2.49e-02 GO:0060089 molecular transducer activity
1.62 3.27e-02 GO:0005244 voltage-gated ion channel activity
1.62 3.27e-02 GO:0022832 voltage-gated channel activity
2.03 4.17e-02 GO:0005200 structural constituent of cytoskeleton
1.96 4.25e-02 GO:0019199 transmembrane receptor protein kinase activity