Motif ID: KLF4.p3

Z-value: 2.485


Transcription factors associated with KLF4.p3:

Gene SymbolEntrez IDGene Name
KLF4 9314 Kruppel-like factor 4 (gut)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
KLF4chr9_-_1102520450.186.5e-03Click!


Activity profile for motif KLF4.p3.

activity profile for motif KLF4.p3


Sorted Z-values histogram for motif KLF4.p3

Sorted Z-values for motif KLF4.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of KLF4.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_-_50143350 54.215 NM_006270
RRAS
related RAS viral (r-ras) oncogene homolog
chr12_-_109125275 54.109 CORO1C
coronin, actin binding protein, 1C
chr11_-_64014140 49.023 PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr12_-_109125289 48.163 NM_014325
CORO1C
coronin, actin binding protein, 1C
chr6_-_4135701 47.450 NM_001166010
NM_006117
NM_206836
ECI2


enoyl-CoA delta isomerase 2


chr4_-_71705545 45.598 GRSF1
G-rich RNA sequence binding factor 1
chrX_-_153599581 45.028 FLNA
filamin A, alpha
chr22_-_36784001 42.900 MYH9
myosin, heavy chain 9, non-muscle
chr12_-_109125254 41.934 CORO1C
coronin, actin binding protein, 1C
chrX_-_152989822 40.426 NM_005745
BCAP31
B-cell receptor-associated protein 31
chr8_+_26149080 37.354 PPP2R2A
protein phosphatase 2, regulatory subunit B, alpha
chr19_+_54695103 37.290 NM_001077446
TSEN34
tRNA splicing endonuclease 34 homolog (S. cerevisiae)
chrX_-_152989851 36.965 BCAP31
B-cell receptor-associated protein 31
chr22_-_36783851 36.581 MYH9
myosin, heavy chain 9, non-muscle
chr11_-_64014264 36.175 PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr19_+_54694118 35.504 NM_024075
TSEN34
tRNA splicing endonuclease 34 homolog (S. cerevisiae)
chr11_-_64014407 34.763 NM_138689
PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr20_+_56884839 33.258 RAB22A
RAB22A, member RAS oncogene family
chr22_-_36783977 32.144 MYH9
myosin, heavy chain 9, non-muscle
chr11_+_65686908 31.868 DRAP1
DR1-associated protein 1 (negative cofactor 2 alpha)
chr11_-_64014381 31.775 PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chrX_-_153599719 31.374 FLNA
filamin A, alpha
chr20_+_56885027 31.297 RAB22A
RAB22A, member RAS oncogene family
chrX_-_152989522 31.266 NM_001139457
NM_001139441
BCAP31

B-cell receptor-associated protein 31

chr20_+_56884749 30.136 NM_020673
RAB22A
RAB22A, member RAS oncogene family
chr15_+_90931470 29.924 NM_003870
IQGAP1
IQ motif containing GTPase activating protein 1
chr9_+_110045516 29.864 NM_002874
RAD23B
RAD23 homolog B (S. cerevisiae)
chr5_+_95998170 29.789 CAST
calpastatin
chr19_+_48828820 27.636 EMP3
epithelial membrane protein 3
chr8_+_26149004 26.953 NM_002717
PPP2R2A
protein phosphatase 2, regulatory subunit B, alpha
chr22_+_43547526 26.558 NM_000714
NM_007311
TSPO

translocator protein (18kDa)

chr15_-_90777191 26.384 NM_006384
CIB1
calcium and integrin binding 1 (calmyrin)
chr6_-_31704093 26.375 CLIC1
chloride intracellular channel 1
chr4_-_103748966 26.368 NM_003340
NM_181886
NM_181888
NM_181889
UBE2D3



ubiquitin-conjugating enzyme E2D 3



chrX_+_49028183 26.264 NM_002668
PLP2
proteolipid protein 2 (colonic epithelium-enriched)
chr4_-_103748254 25.915 NM_181892
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr12_+_69004684 25.880 RAP1B
RAP1B, member of RAS oncogene family
chr2_+_85132999 25.836 TMSB10
thymosin beta 10
chr1_+_40506254 25.580 NM_001105530
NM_006367
CAP1

CAP, adenylate cyclase-associated protein 1 (yeast)

chr22_-_36784055 25.395 NM_002473
MYH9
myosin, heavy chain 9, non-muscle
chr11_-_2950593 25.265 NM_003311
PHLDA2
pleckstrin homology-like domain, family A, member 2
chr12_+_69004710 25.250 RAP1B
RAP1B, member of RAS oncogene family
chr11_+_65686727 24.796 NM_006442
DRAP1
DR1-associated protein 1 (negative cofactor 2 alpha)
chr12_+_69004614 24.765 NM_001010942
NM_001251917
NM_001251918
NM_001251921
NM_001251922
NM_015646
RAP1B





RAP1B, member of RAS oncogene family





chr6_-_31704287 24.445 CLIC1
chloride intracellular channel 1
chr20_+_62371109 24.291 NM_020062
SLC2A4RG
SLC2A4 regulator
chrX_-_152989807 24.274


chr14_-_74960035 24.182 NM_006432
NPC2
Niemann-Pick disease, type C2
chr6_-_31704281 24.008 CLIC1
chloride intracellular channel 1
chr8_+_26149043 23.830 PPP2R2A
protein phosphatase 2, regulatory subunit B, alpha
chr1_+_65886130 23.710 NM_001198683
NM_017526
LEPROT

leptin receptor overlapping transcript

chr1_+_26606443 23.583 SH3BGRL3
SH3 domain binding glutamic acid-rich protein like 3
chr8_-_101962767 23.582 NM_001135702
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr19_+_50180492 23.355 PRMT1
protein arginine methyltransferase 1
chr1_-_33815411 23.262 PHC2
polyhomeotic homolog 2 (Drosophila)
chr12_+_120933911 23.047 DYNLL1
dynein, light chain, LC8-type 1
chr18_+_11981552 23.025 IMPA2
inositol(myo)-1(or 4)-monophosphatase 2
chr9_+_110045551 23.003 RAD23B
RAD23 homolog B (S. cerevisiae)
chr16_+_2564000 22.847 ATP6V0C
ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
chr17_-_4851688 22.334 PFN1
profilin 1
chr1_+_40506449 22.069 CAP1
CAP, adenylate cyclase-associated protein 1 (yeast)
chr10_-_3214979 21.983 NM_001242307
NM_001242309
NM_014889
PITRM1


pitrilysin metallopeptidase 1


chrX_-_153775064 21.903 NM_000402
G6PD
glucose-6-phosphate dehydrogenase
chr2_+_235860616 21.733 NM_014521
SH3BP4
SH3-domain binding protein 4
chr1_-_152009467 21.668 S100A11
S100 calcium binding protein A11
chr18_+_11981421 21.570 NM_014214
IMPA2
inositol(myo)-1(or 4)-monophosphatase 2
chr19_+_48828627 21.403 NM_001425
EMP3
epithelial membrane protein 3
chr4_-_103748649 21.365 NM_181887
NM_181891
UBE2D3

ubiquitin-conjugating enzyme E2D 3

chr6_-_86352982 21.283 NM_001159677
NM_006372
SYNCRIP

synaptotagmin binding, cytoplasmic RNA interacting protein

chr6_-_31704070 21.138 CLIC1
chloride intracellular channel 1
chr9_+_110045565 21.016 RAD23B
RAD23 homolog B (S. cerevisiae)
chr20_+_388717 20.917 RBCK1
RanBP-type and C3HC4-type zinc finger containing 1
chr20_+_388941 20.825 RBCK1
RanBP-type and C3HC4-type zinc finger containing 1
chr2_-_215674292 20.683 NM_000465
BARD1
BRCA1 associated RING domain 1
chr18_+_29671925 20.616 RNF138
ring finger protein 138
chr2_+_114647699 20.546 ACTR3
ARP3 actin-related protein 3 homolog (yeast)
chr10_+_120863558 20.487 FAM45A
family with sequence similarity 45, member A
chrX_-_153775427 20.352 G6PD
glucose-6-phosphate dehydrogenase
chr13_+_28196029 20.310 POLR1D
polymerase (RNA) I polypeptide D, 16kDa
chr1_+_40506423 20.212 CAP1
CAP, adenylate cyclase-associated protein 1 (yeast)
chr10_-_3214963 20.173 PITRM1
pitrilysin metallopeptidase 1
chr20_+_43514340 20.085 NM_003404
NM_139323
YWHAB

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide

chr12_+_120933832 19.940 NM_001037495
NM_003746
DYNLL1

dynein, light chain, LC8-type 1

chr15_-_90777144 19.802 CIB1
calcium and integrin binding 1 (calmyrin)
chr17_+_45727274 19.792 NM_002265
KPNB1
karyopherin (importin) beta 1
chr20_+_62371218 19.581 SLC2A4RG
SLC2A4 regulator
chr1_+_182992329 19.571 NM_002293
LAMC1
laminin, gamma 1 (formerly LAMB2)
chr1_+_40506436 19.315 CAP1
CAP, adenylate cyclase-associated protein 1 (yeast)
chr3_+_38207247 19.162 OXSR1
oxidative-stress responsive 1
chrX_+_118708540 19.111 UBE2A
ubiquitin-conjugating enzyme E2A
chr8_-_101965194 19.109 NM_001135699
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr1_+_40506384 18.988 CAP1
CAP, adenylate cyclase-associated protein 1 (yeast)
chr3_+_38206968 18.945 NM_005109
OXSR1
oxidative-stress responsive 1
chr22_+_43547558 18.943 TSPO
translocator protein (18kDa)
chr7_+_116166346 18.888 NM_001172896
NM_001172897
CAV1

caveolin 1, caveolae protein, 22kDa

chr10_-_126849556 18.767 NM_001083914
CTBP2
C-terminal binding protein 2
chr2_+_242255365 18.692 SEPT2
septin 2
chr1_-_205719157 18.571 NUCKS1
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr3_+_50273745 18.554 GNAI2
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
chr1_+_40506406 18.519 CAP1
CAP, adenylate cyclase-associated protein 1 (yeast)
chr14_+_105941061 18.367 NM_001312
CRIP2
cysteine-rich protein 2
chr15_-_60690115 18.268 NM_001002857
NM_001002858
NM_001136015
NM_004039
ANXA2



annexin A2



chr10_+_82213892 18.160 NM_001128309
NM_030927
TSPAN14

tetraspanin 14

chr1_+_87170515 17.944 SH3GLB1
SH3-domain GRB2-like endophilin B1
chr2_+_238600878 17.905 LRRFIP1
leucine rich repeat (in FLII) interacting protein 1
chr12_+_53342842 17.800 NM_000224
KRT18
keratin 18
chr3_-_33481862 17.631 NM_001128160
NM_014517
UBP1

upstream binding protein 1 (LBP-1a)

chr10_-_3214907 17.573 PITRM1
pitrilysin metallopeptidase 1
chr1_-_151966303 17.468 S100A10
S100 calcium binding protein A10
chr17_-_62658175 17.455 SMURF2
SMAD specific E3 ubiquitin protein ligase 2
chr6_-_7313352 17.453 NM_003144
SSR1
signal sequence receptor, alpha
chr20_+_43514350 17.417 YWHAB
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
chr14_-_35099296 17.208 NM_021249
NM_152233
SNX6

sorting nexin 6

chr3_+_49711751 17.206 APEH
N-acylaminoacyl-peptide hydrolase
chr6_-_159065739 17.168 NM_006519
DYNLT1
dynein, light chain, Tctex-type 1
chr19_-_50432952 17.161 NM_016553
NUP62
nucleoporin 62kDa
chr9_-_113018711 17.097 TXN
thioredoxin
chr1_-_151966713 17.086 NM_002966
S100A10
S100 calcium binding protein A10
chr18_+_3449972 17.074 NM_173209
NM_173208
NM_003244
TGIF1


TGFB-induced factor homeobox 1


chr11_-_67188614 17.064 PPP1CA
protein phosphatase 1, catalytic subunit, alpha isozyme
chr19_-_33166057 16.989 NM_032139
ANKRD27
ankyrin repeat domain 27 (VPS9 domain)
chr19_+_50180408 16.949 NM_001207042
NM_001536
NM_198318
PRMT1


protein arginine methyltransferase 1


chr22_+_24951617 16.935 NM_004175
SNRPD3
small nuclear ribonucleoprotein D3 polypeptide 18kDa
chr2_-_37899227 16.811 NM_006449
CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chr14_-_74960003 16.707 NPC2
Niemann-Pick disease, type C2
chrX_+_64887510 16.602 NM_002444
MSN
moesin
chr5_+_95998678 16.491 CAST
calpastatin
chr1_-_113249677 16.447 NM_001042679
RHOC
ras homolog gene family, member C
chr4_-_71705613 16.405 NM_002092
GRSF1
G-rich RNA sequence binding factor 1
chr11_-_66234176 16.362 MRPL11
mitochondrial ribosomal protein L11
chr9_-_113018802 16.325 TXN
thioredoxin
chr19_-_42806460 16.280 NM_002573
PAFAH1B3
platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
chr18_-_51750934 16.257 MBD2
methyl-CpG binding domain protein 2
chr1_+_26606621 16.253 SH3BGRL3
SH3 domain binding glutamic acid-rich protein like 3
chr14_-_74959976 16.213 NPC2
Niemann-Pick disease, type C2
chr15_+_90931449 16.206 IQGAP1
IQ motif containing GTPase activating protein 1
chr22_-_19166133 16.070 SLC25A1
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
chr1_-_33815340 16.042 PHC2
polyhomeotic homolog 2 (Drosophila)
chr13_+_32420828 16.041 EEF1DP3
eukaryotic translation elongation factor 1 delta pseudogene 3
chr4_-_39529099 16.011 NM_001184700
NM_001184701
NM_003359
UGDH


UDP-glucose 6-dehydrogenase


chr8_-_124428589 16.005 ATAD2
ATPase family, AAA domain containing 2
chr11_+_64009587 15.963 NM_057092
FKBP2
FK506 binding protein 2, 13kDa
chr6_+_31633656 15.921 NM_001320
CSNK2B
casein kinase 2, beta polypeptide
chr1_-_1822501 15.879 GNB1
guanine nucleotide binding protein (G protein), beta polypeptide 1
chr1_-_222885653 15.820 NM_022831
AIDA
axin interactor, dorsalization associated
chr11_-_64645925 15.719 EHD1
EH-domain containing 1
chr1_-_205719340 15.684 NM_022731
NUCKS1
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr5_+_10353980 15.595


chr8_+_98656428 15.534 MTDH
metadherin
chr19_+_6739697 15.518 NM_004240
TRIP10
thyroid hormone receptor interactor 10
chr12_+_6875686 15.441 PTMS
parathymosin
chr18_-_9614555 15.234 NM_001042388
NM_005134
PPP4R1

protein phosphatase 4, regulatory subunit 1

chr12_+_6875468 15.169 NM_002824
PTMS
parathymosin
chr2_-_32235603 15.097 NM_001137602
NM_015955
MEMO1

mediator of cell motility 1

chr10_+_75757847 15.085 NM_003373
NM_014000
VCL

vinculin

chr17_-_62658311 15.014 NM_022739
SMURF2
SMAD specific E3 ubiquitin protein ligase 2
chr2_+_85198431 15.011 KCMF1
potassium channel modulatory factor 1
chr12_+_53342899 14.947 KRT18
keratin 18
chr3_+_50273645 14.921 NM_002070
GNAI2
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
chr18_-_9614454 14.906 PPP4R1
protein phosphatase 4, regulatory subunit 1
chr4_-_39528921 14.861 UGDH
UDP-glucose 6-dehydrogenase
chr7_+_26241372 14.861 CBX3
chromobox homolog 3
chr22_+_41347328 14.777 NM_014248
RBX1
ring-box 1, E3 ubiquitin protein ligase
chr3_+_52719935 14.720 NM_014366
NM_206825
NM_206826
GNL3


guanine nucleotide binding protein-like 3 (nucleolar)


chr17_-_66453561 14.692 NM_017983
WIPI1
WD repeat domain, phosphoinositide interacting 1
chr10_+_120863626 14.666 FAM45A
FAM45B
family with sequence similarity 45, member A
family with sequence similarity 45, member A pseudogene
chr22_+_39898365 14.658 SMCR7L
Smith-Magenis syndrome chromosome region, candidate 7-like
chr10_+_70883856 14.648 NM_001035260
NM_004896
VPS26A

vacuolar protein sorting 26 homolog A (S. pombe)

chr20_+_32581725 14.591 RALY
RNA binding protein, autoantigenic (hnRNP-associated with lethal yellow homolog (mouse))
chr2_-_10588451 14.578 NM_002539
ODC1
ornithine decarboxylase 1
chr2_-_37898768 14.556 CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chrX_+_64887534 14.555 MSN
moesin
chr2_-_220252627 14.547 NM_012100
DNPEP
aspartyl aminopeptidase
chr7_+_116139619 14.523 NM_001206747
NM_001233
NM_198212
CAV2


caveolin 2


chr6_+_30689414 14.517 TUBB
tubulin, beta class I
chr17_+_76164624 14.511 NM_004710
SYNGR2
synaptogyrin 2
chr15_+_75074714 14.444 CSK
c-src tyrosine kinase
chr10_+_70883930 14.432 VPS26A
vacuolar protein sorting 26 homolog A (S. pombe)
chr4_-_2935851 14.423 NM_001120
MFSD10
major facilitator superfamily domain containing 10
chr1_+_193028598 14.412 TROVE2
TROVE domain family, member 2
chr2_-_10588273 14.391 ODC1
ornithine decarboxylase 1
chr12_+_120933916 14.357 DYNLL1
dynein, light chain, LC8-type 1
chr7_-_94285372 14.316 SGCE
sarcoglycan, epsilon
chr1_-_153508463 14.302 S100A6
S100 calcium binding protein A6
chr7_-_94285426 14.283 SGCE
sarcoglycan, epsilon
chr12_-_56122800 14.241 CD63
CD63 molecule
chr1_-_151966276 14.227 S100A10
S100 calcium binding protein A10
chr5_+_137673953 14.197 FAM53C
family with sequence similarity 53, member C
chr1_-_54411245 14.189 NM_016126
HSPB11
heat shock protein family B (small), member 11
chr21_-_45196149 14.181 CSTB
cystatin B (stefin B)
chr1_-_183604793 14.127 ARPC5
actin related protein 2/3 complex, subunit 5, 16kDa
chr17_+_75277491 14.121 NM_001113491
SEPT9
septin 9
chr16_-_75529278 14.098


chr19_+_14544216 14.092 PKN1
protein kinase N1
chr7_-_105925329 14.058 NAMPT
nicotinamide phosphoribosyltransferase
chr2_+_27651483 13.896 NRBP1
nuclear receptor binding protein 1
chr19_-_48894615 13.894 KDELR1
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1
chr9_-_111775721 13.872 NM_003798
CTNNAL1
catenin (cadherin-associated protein), alpha-like 1
chrX_+_106871739 13.859 PRPS1
phosphoribosyl pyrophosphate synthetase 1
chr18_+_29672568 13.839 NM_001191324
NM_198128
RNF138

ring finger protein 138


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.17 3.44e-83 GO:0009987 cellular process
1.27 3.88e-57 GO:0044237 cellular metabolic process
1.22 2.33e-50 GO:0008152 metabolic process
1.24 6.17e-46 GO:0044238 primary metabolic process
1.29 2.26e-39 GO:0044260 cellular macromolecule metabolic process
1.18 5.60e-38 GO:0065007 biological regulation
1.25 7.25e-36 GO:0043170 macromolecule metabolic process
1.18 5.22e-33 GO:0050789 regulation of biological process
1.31 3.18e-31 GO:0006807 nitrogen compound metabolic process
1.18 8.11e-30 GO:0050794 regulation of cellular process
1.30 8.07e-29 GO:0034641 cellular nitrogen compound metabolic process
1.32 2.19e-27 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.27 6.46e-24 GO:0016043 cellular component organization
1.26 7.42e-23 GO:0071840 cellular component organization or biogenesis
1.30 1.82e-22 GO:0048518 positive regulation of biological process
1.31 3.53e-21 GO:0048522 positive regulation of cellular process
1.33 1.29e-20 GO:0048523 negative regulation of cellular process
1.22 1.12e-19 GO:0051716 cellular response to stimulus
1.30 2.05e-19 GO:0048519 negative regulation of biological process
1.29 8.35e-18 GO:0044249 cellular biosynthetic process
1.28 1.16e-17 GO:0044267 cellular protein metabolic process
1.27 2.35e-17 GO:0071842 cellular component organization at cellular level
1.28 3.07e-17 GO:0009058 biosynthetic process
1.45 3.76e-17 GO:0042981 regulation of apoptosis
1.30 5.68e-17 GO:0090304 nucleic acid metabolic process
1.45 7.39e-17 GO:0043067 regulation of programmed cell death
1.44 2.17e-16 GO:0010941 regulation of cell death
1.26 3.22e-16 GO:0071841 cellular component organization or biogenesis at cellular level
1.34 1.05e-15 GO:0006996 organelle organization
1.22 1.67e-15 GO:0007165 signal transduction
1.20 2.36e-15 GO:0019222 regulation of metabolic process
1.30 2.47e-15 GO:0043412 macromolecule modification
1.31 2.59e-15 GO:0006464 protein modification process
1.40 3.59e-15 GO:0010604 positive regulation of macromolecule metabolic process
1.20 3.66e-15 GO:0023052 signaling
1.38 8.96e-15 GO:0009893 positive regulation of metabolic process
1.23 2.37e-14 GO:0019538 protein metabolic process
1.31 2.48e-14 GO:0044281 small molecule metabolic process
1.46 2.57e-14 GO:0008219 cell death
1.45 6.90e-14 GO:0016265 death
1.20 1.05e-13 GO:0031323 regulation of cellular metabolic process
1.27 2.08e-13 GO:0065008 regulation of biological quality
1.20 3.06e-13 GO:0080090 regulation of primary metabolic process
1.37 6.19e-13 GO:0031325 positive regulation of cellular metabolic process
1.30 6.98e-13 GO:0009059 macromolecule biosynthetic process
1.26 1.18e-12 GO:0042221 response to chemical stimulus
1.30 1.43e-12 GO:0034645 cellular macromolecule biosynthetic process
1.24 2.17e-12 GO:0006950 response to stress
1.32 4.98e-12 GO:0009056 catabolic process
1.28 5.58e-12 GO:0010467 gene expression
1.20 6.62e-12 GO:0060255 regulation of macromolecule metabolic process
1.18 7.51e-12 GO:0032502 developmental process
1.29 7.71e-12 GO:0016070 RNA metabolic process
1.34 8.74e-12 GO:0051641 cellular localization
1.36 9.18e-12 GO:0044248 cellular catabolic process
1.13 1.81e-11 GO:0050896 response to stimulus
1.43 3.80e-11 GO:0046907 intracellular transport
1.45 5.00e-11 GO:0012501 programmed cell death
1.45 1.05e-10 GO:0006915 apoptosis
1.37 2.07e-10 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.32 2.23e-10 GO:0033036 macromolecule localization
1.18 3.54e-10 GO:0007275 multicellular organismal development
1.19 9.02e-10 GO:0048856 anatomical structure development
1.18 1.20e-09 GO:0051179 localization
1.50 3.31e-09 GO:0043065 positive regulation of apoptosis
1.50 3.73e-09 GO:0043068 positive regulation of programmed cell death
1.38 6.71e-09 GO:0051128 regulation of cellular component organization
1.43 8.48e-09 GO:0046483 heterocycle metabolic process
1.53 9.51e-09 GO:0072521 purine-containing compound metabolic process
1.32 1.41e-08 GO:0051649 establishment of localization in cell
1.30 1.50e-08 GO:0010033 response to organic substance
1.48 1.56e-08 GO:0010942 positive regulation of cell death
1.32 1.62e-08 GO:0051246 regulation of protein metabolic process
1.19 2.12e-08 GO:0051171 regulation of nitrogen compound metabolic process
1.34 2.93e-08 GO:0009892 negative regulation of metabolic process
1.34 3.44e-08 GO:0042127 regulation of cell proliferation
1.35 3.80e-08 GO:0031324 negative regulation of cellular metabolic process
1.33 4.06e-08 GO:0032268 regulation of cellular protein metabolic process
1.45 4.10e-08 GO:0055086 nucleobase, nucleoside and nucleotide metabolic process
1.53 4.39e-08 GO:0051247 positive regulation of protein metabolic process
1.33 5.76e-08 GO:0007049 cell cycle
1.51 5.93e-08 GO:0043069 negative regulation of programmed cell death
1.41 7.67e-08 GO:0007167 enzyme linked receptor protein signaling pathway
1.34 7.93e-08 GO:0070887 cellular response to chemical stimulus
1.51 8.04e-08 GO:0043066 negative regulation of apoptosis
1.37 8.26e-08 GO:0051173 positive regulation of nitrogen compound metabolic process
1.49 9.59e-08 GO:0060548 negative regulation of cell death
1.34 1.21e-07 GO:0010605 negative regulation of macromolecule metabolic process
1.46 1.42e-07 GO:0006753 nucleoside phosphate metabolic process
1.46 1.42e-07 GO:0009117 nucleotide metabolic process
1.31 1.43e-07 GO:0008104 protein localization
1.35 1.67e-07 GO:0006351 transcription, DNA-dependent
1.36 1.70e-07 GO:0033554 cellular response to stress
1.52 1.70e-07 GO:0006163 purine nucleotide metabolic process
1.18 2.65e-07 GO:0048731 system development
1.37 2.69e-07 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.54 3.30e-07 GO:0016568 chromatin modification
1.49 4.48e-07 GO:0008285 negative regulation of cell proliferation
1.39 4.88e-07 GO:0010628 positive regulation of gene expression
1.40 5.69e-07 GO:0051726 regulation of cell cycle
1.17 7.94e-07 GO:0051234 establishment of localization
1.40 8.67e-07 GO:0009725 response to hormone stimulus
1.18 9.10e-07 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.51 9.60e-07 GO:0032270 positive regulation of cellular protein metabolic process
1.63 1.07e-06 GO:0072523 purine-containing compound catabolic process
1.38 1.28e-06 GO:0051254 positive regulation of RNA metabolic process
1.40 1.42e-06 GO:0051276 chromosome organization
1.45 1.52e-06 GO:0006325 chromatin organization
1.17 1.62e-06 GO:0006810 transport
1.63 1.69e-06 GO:0006195 purine nucleotide catabolic process
1.23 1.96e-06 GO:0023051 regulation of signaling
1.32 2.17e-06 GO:0050793 regulation of developmental process
1.18 2.21e-06 GO:0031326 regulation of cellular biosynthetic process
1.18 2.48e-06 GO:0010468 regulation of gene expression
1.29 2.73e-06 GO:0022607 cellular component assembly
1.53 2.79e-06 GO:0009259 ribonucleotide metabolic process
1.38 2.98e-06 GO:0071310 cellular response to organic substance
1.30 3.25e-06 GO:0032774 RNA biosynthetic process
1.34 3.25e-06 GO:0031399 regulation of protein modification process
1.27 3.30e-06 GO:0002376 immune system process
1.55 3.38e-06 GO:0031401 positive regulation of protein modification process
1.42 3.42e-06 GO:0044282 small molecule catabolic process
1.30 3.61e-06 GO:0006793 phosphorus metabolic process
1.30 3.61e-06 GO:0006796 phosphate metabolic process
1.19 3.79e-06 GO:0051252 regulation of RNA metabolic process
1.42 3.81e-06 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.40 4.39e-06 GO:0000278 mitotic cell cycle
1.25 4.42e-06 GO:0035556 intracellular signal transduction
1.43 4.58e-06 GO:0007599 hemostasis
1.40 5.05e-06 GO:0050878 regulation of body fluid levels
1.17 7.24e-06 GO:0009889 regulation of biosynthetic process
1.50 8.20e-06 GO:0018193 peptidyl-amino acid modification
1.36 9.09e-06 GO:0045595 regulation of cell differentiation
1.74 9.35e-06 GO:0031400 negative regulation of protein modification process
1.23 9.59e-06 GO:0009653 anatomical structure morphogenesis
1.37 9.65e-06 GO:0045893 positive regulation of transcription, DNA-dependent
1.24 1.05e-05 GO:0065009 regulation of molecular function
1.32 1.06e-05 GO:0031328 positive regulation of cellular biosynthetic process
1.20 1.14e-05 GO:0030154 cell differentiation
1.26 1.22e-05 GO:0044085 cellular component biogenesis
1.18 1.26e-05 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.36 1.36e-05 GO:0009719 response to endogenous stimulus
1.42 1.39e-05 GO:0007596 blood coagulation
1.42 1.39e-05 GO:0050817 coagulation
1.33 1.41e-05 GO:2000026 regulation of multicellular organismal development
1.19 1.80e-05 GO:0048869 cellular developmental process
1.51 1.89e-05 GO:0009150 purine ribonucleotide metabolic process
1.40 2.05e-05 GO:0070727 cellular macromolecule localization
1.24 2.14e-05 GO:0009966 regulation of signal transduction
1.20 2.27e-05 GO:0048583 regulation of response to stimulus
1.31 2.32e-05 GO:0009891 positive regulation of biosynthetic process
1.49 2.39e-05 GO:0012502 induction of programmed cell death
1.30 2.47e-05 GO:0045184 establishment of protein localization
1.27 3.09e-05 GO:0010646 regulation of cell communication
1.48 3.60e-05 GO:0006917 induction of apoptosis
1.60 4.27e-05 GO:0009261 ribonucleotide catabolic process
1.53 4.44e-05 GO:0034655 nucleobase, nucleoside, nucleotide and nucleic acid catabolic process
1.53 4.44e-05 GO:0034656 nucleobase, nucleoside and nucleotide catabolic process
1.25 4.51e-05 GO:0050790 regulation of catalytic activity
1.60 4.98e-05 GO:0009154 purine ribonucleotide catabolic process
1.36 5.30e-05 GO:0051172 negative regulation of nitrogen compound metabolic process
1.39 5.85e-05 GO:0034613 cellular protein localization
1.56 6.20e-05 GO:0051248 negative regulation of protein metabolic process
1.31 6.44e-05 GO:0022402 cell cycle process
1.36 7.84e-05 GO:0042060 wound healing
1.47 8.08e-05 GO:0010564 regulation of cell cycle process
1.50 8.09e-05 GO:0032870 cellular response to hormone stimulus
1.17 8.23e-05 GO:0010556 regulation of macromolecule biosynthetic process
1.54 8.34e-05 GO:0009166 nucleotide catabolic process
1.32 8.57e-05 GO:0010557 positive regulation of macromolecule biosynthetic process
1.35 8.79e-05 GO:0009057 macromolecule catabolic process
1.30 9.08e-05 GO:0015031 protein transport
1.22 9.23e-05 GO:0007399 nervous system development
1.80 9.77e-05 GO:0007265 Ras protein signal transduction
2.03 1.04e-04 GO:0031346 positive regulation of cell projection organization
1.49 1.06e-04 GO:0044270 cellular nitrogen compound catabolic process
1.35 1.09e-04 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.39 1.10e-04 GO:0070271 protein complex biogenesis
1.53 1.27e-04 GO:0007346 regulation of mitotic cell cycle
1.41 1.33e-04 GO:0044262 cellular carbohydrate metabolic process
1.28 1.42e-04 GO:0009611 response to wounding
1.49 1.43e-04 GO:0046700 heterocycle catabolic process
1.50 1.48e-04 GO:0051130 positive regulation of cellular component organization
1.43 1.49e-04 GO:0006886 intracellular protein transport
1.58 1.51e-04 GO:0009203 ribonucleoside triphosphate catabolic process
1.58 1.51e-04 GO:0009207 purine ribonucleoside triphosphate catabolic process
1.30 1.73e-04 GO:0044093 positive regulation of molecular function
1.39 1.78e-04 GO:0006461 protein complex assembly
1.17 1.82e-04 GO:0006355 regulation of transcription, DNA-dependent
1.57 2.08e-04 GO:0009146 purine nucleoside triphosphate catabolic process
1.45 2.27e-04 GO:0044419 interspecies interaction between organisms
1.40 2.54e-04 GO:0061024 membrane organization
1.32 2.69e-04 GO:0022403 cell cycle phase
1.54 2.82e-04 GO:0032269 negative regulation of cellular protein metabolic process
1.40 2.92e-04 GO:0016044 cellular membrane organization
1.46 3.38e-04 GO:0045597 positive regulation of cell differentiation
1.48 3.94e-04 GO:0006366 transcription from RNA polymerase II promoter
1.36 4.09e-04 GO:0051253 negative regulation of RNA metabolic process
1.50 4.50e-04 GO:0048545 response to steroid hormone stimulus
1.55 5.26e-04 GO:0009143 nucleoside triphosphate catabolic process
1.31 6.21e-04 GO:0031327 negative regulation of cellular biosynthetic process
1.38 6.22e-04 GO:0006066 alcohol metabolic process
1.57 8.24e-04 GO:0044087 regulation of cellular component biogenesis
1.46 9.00e-04 GO:0051325 interphase
1.32 9.15e-04 GO:0005975 carbohydrate metabolic process
1.46 9.43e-04 GO:0051329 interphase of mitotic cell cycle
1.54 9.63e-04 GO:0005996 monosaccharide metabolic process
1.79 1.16e-03 GO:0010720 positive regulation of cell development
1.44 1.19e-03 GO:0071495 cellular response to endogenous stimulus
1.35 1.21e-03 GO:0006974 response to DNA damage stimulus
1.18 1.30e-03 GO:0007166 cell surface receptor linked signaling pathway
1.33 1.33e-03 GO:0071822 protein complex subunit organization
1.30 1.42e-03 GO:0065003 macromolecular complex assembly
1.46 1.47e-03 GO:0009199 ribonucleoside triphosphate metabolic process
1.22 1.50e-03 GO:0051239 regulation of multicellular organismal process
1.32 1.79e-03 GO:0006259 DNA metabolic process
1.30 2.05e-03 GO:0009890 negative regulation of biosynthetic process
1.57 2.06e-03 GO:0019318 hexose metabolic process
1.74 2.13e-03 GO:0042770 signal transduction in response to DNA damage
1.27 2.15e-03 GO:0043933 macromolecular complex subunit organization
1.46 2.17e-03 GO:0009205 purine ribonucleoside triphosphate metabolic process
1.45 2.40e-03 GO:0009144 purine nucleoside triphosphate metabolic process
1.34 2.43e-03 GO:0044265 cellular macromolecule catabolic process
1.87 3.04e-03 GO:0008629 induction of apoptosis by intracellular signals
1.29 3.04e-03 GO:0009790 embryo development
1.31 3.22e-03 GO:0010629 negative regulation of gene expression
1.33 3.46e-03 GO:0045892 negative regulation of transcription, DNA-dependent
1.36 3.54e-03 GO:0051094 positive regulation of developmental process
1.39 3.57e-03 GO:0007264 small GTPase mediated signal transduction
1.33 3.62e-03 GO:0016071 mRNA metabolic process
1.44 3.66e-03 GO:0009141 nucleoside triphosphate metabolic process
1.25 3.72e-03 GO:0051704 multi-organism process
1.30 3.81e-03 GO:0006396 RNA processing
1.51 4.04e-03 GO:0071156 regulation of cell cycle arrest
1.25 4.06e-03 GO:0022008 neurogenesis
1.24 4.23e-03 GO:0032879 regulation of localization
1.25 4.53e-03 GO:0055114 oxidation-reduction process
1.28 4.69e-03 GO:0006468 protein phosphorylation
1.28 5.10e-03 GO:0043085 positive regulation of catalytic activity
1.27 5.11e-03 GO:0071844 cellular component assembly at cellular level
1.42 5.94e-03 GO:0060284 regulation of cell development
1.26 6.01e-03 GO:0016310 phosphorylation
1.41 6.05e-03 GO:0033043 regulation of organelle organization
1.50 6.17e-03 GO:0048011 nerve growth factor receptor signaling pathway
1.25 6.89e-03 GO:0048699 generation of neurons
1.25 8.01e-03 GO:0042592 homeostatic process
1.27 8.04e-03 GO:0016192 vesicle-mediated transport
1.82 8.25e-03 GO:0048872 homeostasis of number of cells
1.29 8.52e-03 GO:0010558 negative regulation of macromolecule biosynthetic process
1.59 9.28e-03 GO:0046039 GTP metabolic process
1.28 9.44e-03 GO:0019220 regulation of phosphate metabolic process
1.28 9.44e-03 GO:0051174 regulation of phosphorus metabolic process
1.29 1.13e-02 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.66 1.18e-02 GO:0043254 regulation of protein complex assembly
1.28 1.19e-02 GO:0042325 regulation of phosphorylation
1.42 1.21e-02 GO:0008380 RNA splicing
1.61 1.23e-02 GO:0006184 GTP catabolic process
1.49 1.27e-02 GO:0045786 negative regulation of cell cycle
1.40 1.44e-02 GO:0032535 regulation of cellular component size
1.52 1.45e-02 GO:0006979 response to oxidative stress
1.49 1.47e-02 GO:0000075 cell cycle checkpoint
1.32 1.52e-02 GO:0007010 cytoskeleton organization
1.47 1.52e-02 GO:0051129 negative regulation of cellular component organization
1.50 1.57e-02 GO:0001701 in utero embryonic development
1.77 1.58e-02 GO:0030099 myeloid cell differentiation
1.59 1.72e-02 GO:0016311 dephosphorylation
1.37 1.83e-02 GO:0090066 regulation of anatomical structure size
1.71 2.08e-02 GO:0043523 regulation of neuron apoptosis
1.53 2.34e-02 GO:0006913 nucleocytoplasmic transport
1.31 2.41e-02 GO:0009308 amine metabolic process
1.40 2.49e-02 GO:0048285 organelle fission
1.36 2.70e-02 GO:0044271 cellular nitrogen compound biosynthetic process
1.44 2.75e-02 GO:0009100 glycoprotein metabolic process
1.79 2.77e-02 GO:0050769 positive regulation of neurogenesis
1.35 2.80e-02 GO:0009968 negative regulation of signal transduction
1.27 2.93e-02 GO:0030030 cell projection organization
1.35 2.95e-02 GO:0006397 mRNA processing
1.35 2.95e-02 GO:0010627 regulation of intracellular protein kinase cascade
1.35 3.28e-02 GO:0006091 generation of precursor metabolites and energy
1.27 3.69e-02 GO:0001932 regulation of protein phosphorylation
1.47 3.88e-02 GO:0006916 anti-apoptosis
1.51 4.11e-02 GO:0051169 nuclear transport
1.31 4.16e-02 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.86 4.36e-02 GO:0030518 steroid hormone receptor signaling pathway
1.21 4.39e-02 GO:0009605 response to external stimulus
1.32 4.51e-02 GO:0010648 negative regulation of cell communication

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.15 1.44e-68 GO:0044424 intracellular part
1.22 1.63e-67 GO:0005737 cytoplasm
1.14 3.03e-63 GO:0005622 intracellular
1.17 3.09e-46 GO:0043227 membrane-bounded organelle
1.15 4.14e-46 GO:0043226 organelle
1.17 1.45e-45 GO:0043231 intracellular membrane-bounded organelle
1.24 1.94e-45 GO:0044444 cytoplasmic part
1.15 5.01e-45 GO:0043229 intracellular organelle
1.42 1.11e-35 GO:0005829 cytosol
1.22 6.32e-35 GO:0044446 intracellular organelle part
1.22 6.59e-35 GO:0044422 organelle part
1.35 5.32e-26 GO:0044428 nuclear part
1.19 3.96e-25 GO:0005634 nucleus
1.33 2.48e-23 GO:0070013 intracellular organelle lumen
1.32 5.63e-23 GO:0031974 membrane-enclosed lumen
1.32 1.18e-22 GO:0043233 organelle lumen
1.42 4.08e-21 GO:0005654 nucleoplasm
1.34 2.49e-19 GO:0031981 nuclear lumen
1.21 1.30e-15 GO:0032991 macromolecular complex
1.22 5.34e-14 GO:0043234 protein complex
1.28 9.78e-11 GO:0012505 endomembrane system
1.32 8.08e-10 GO:0000267 cell fraction
1.35 8.74e-09 GO:0005626 insoluble fraction
1.38 1.17e-08 GO:0044451 nucleoplasm part
1.03 1.67e-08 GO:0044464 cell part
1.03 1.84e-08 GO:0005623 cell
1.21 2.00e-08 GO:0031090 organelle membrane
1.31 4.21e-08 GO:0005794 Golgi apparatus
1.33 4.25e-07 GO:0005624 membrane fraction
1.25 1.88e-05 GO:0005783 endoplasmic reticulum
1.44 2.68e-05 GO:0048471 perinuclear region of cytoplasm
1.48 3.50e-05 GO:0015629 actin cytoskeleton
1.15 4.35e-05 GO:0043228 non-membrane-bounded organelle
1.15 4.35e-05 GO:0043232 intracellular non-membrane-bounded organelle
1.61 1.49e-04 GO:0070161 anchoring junction
1.64 2.16e-04 GO:0005912 adherens junction
2.81 5.78e-04 GO:0030530 heterogeneous nuclear ribonucleoprotein complex
1.30 1.36e-03 GO:0005694 chromosome
1.25 1.38e-03 GO:0031982 vesicle
1.26 1.71e-03 GO:0044432 endoplasmic reticulum part
1.19 1.75e-03 GO:0005739 mitochondrion
1.47 1.90e-03 GO:0016604 nuclear body
1.45 2.12e-03 GO:0005635 nuclear envelope
1.25 2.44e-03 GO:0031410 cytoplasmic vesicle
1.26 2.57e-03 GO:0031967 organelle envelope
1.86 2.59e-03 GO:0034399 nuclear periphery
1.74 2.65e-03 GO:0016585 chromatin remodeling complex
1.26 2.83e-03 GO:0031975 envelope
1.17 3.06e-03 GO:0005856 cytoskeleton
1.32 3.64e-03 GO:0044427 chromosomal part
1.44 4.20e-03 GO:0000785 chromatin
1.32 5.09e-03 GO:0005768 endosome
1.24 5.96e-03 GO:0031988 membrane-bounded vesicle
1.66 9.70e-03 GO:0005925 focal adhesion
1.24 9.99e-03 GO:0016023 cytoplasmic membrane-bounded vesicle
1.27 1.00e-02 GO:0044431 Golgi apparatus part
1.84 1.18e-02 GO:0016363 nuclear matrix
1.61 1.79e-02 GO:0030055 cell-substrate junction
2.01 2.15e-02 GO:0008287 protein serine/threonine phosphatase complex
2.03 2.34e-02 GO:0000118 histone deacetylase complex
1.24 2.37e-02 GO:0005789 endoplasmic reticulum membrane
1.61 2.44e-02 GO:0005924 cell-substrate adherens junction
1.23 3.04e-02 GO:0015630 microtubule cytoskeleton
1.94 3.55e-02 GO:0017053 transcriptional repressor complex
1.23 3.69e-02 GO:0042175 nuclear membrane-endoplasmic reticulum network

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.29 1.46e-90 GO:0005515 protein binding
1.14 1.31e-65 GO:0005488 binding
1.52 4.57e-17 GO:0019899 enzyme binding
1.25 1.01e-13 GO:0000166 nucleotide binding
1.46 2.85e-11 GO:0046983 protein dimerization activity
1.13 3.94e-11 GO:0003824 catalytic activity
1.25 2.12e-10 GO:0017076 purine nucleotide binding
1.25 3.59e-10 GO:0035639 purine ribonucleoside triphosphate binding
1.24 5.56e-10 GO:0032553 ribonucleotide binding
1.24 5.56e-10 GO:0032555 purine ribonucleotide binding
1.34 1.39e-06 GO:0042802 identical protein binding
1.47 1.98e-06 GO:0000988 protein binding transcription factor activity
1.47 1.98e-06 GO:0000989 transcription factor binding transcription factor activity
1.44 2.36e-06 GO:0019904 protein domain specific binding
1.47 2.96e-06 GO:0003712 transcription cofactor activity
1.31 3.57e-06 GO:0003723 RNA binding
1.22 3.66e-06 GO:0030554 adenyl nucleotide binding
1.22 8.85e-06 GO:0005524 ATP binding
1.22 1.09e-05 GO:0032559 adenyl ribonucleotide binding
1.39 1.46e-04 GO:0042803 protein homodimerization activity
1.54 4.34e-04 GO:0003924 GTPase activity
1.50 6.19e-04 GO:0046982 protein heterodimerization activity
1.24 1.34e-03 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.84 1.45e-03 GO:0031625 ubiquitin protein ligase binding
1.25 2.58e-03 GO:0016301 kinase activity
1.25 7.88e-03 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.16 9.42e-03 GO:0016740 transferase activity
1.35 1.05e-02 GO:0005525 GTP binding
1.34 1.76e-02 GO:0019001 guanyl nucleotide binding
1.34 1.76e-02 GO:0032561 guanyl ribonucleotide binding
1.28 2.07e-02 GO:0008092 cytoskeletal protein binding
1.23 2.16e-02 GO:0017111 nucleoside-triphosphatase activity
1.20 2.74e-02 GO:0005102 receptor binding
1.43 2.92e-02 GO:0003713 transcription coactivator activity
1.53 3.15e-02 GO:0003714 transcription corepressor activity
1.45 3.32e-02 GO:0010843 promoter binding
1.50 3.42e-02 GO:0004721 phosphoprotein phosphatase activity
1.44 3.46e-02 GO:0000975 regulatory region DNA binding
1.44 3.46e-02 GO:0001067 regulatory region nucleic acid binding
1.44 3.46e-02 GO:0044212 transcription regulatory region DNA binding
1.40 4.37e-02 GO:0019900 kinase binding