Motif ID: LHX3,4.p2

Z-value: 1.022


Transcription factors associated with LHX3,4.p2:

Gene SymbolEntrez IDGene Name
LHX3 8022 LIM homeobox 3
LHX4 89884 LIM homeobox 4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
LHX3chr9_-_1390948860.171.4e-02Click!


Activity profile for motif LHX3,4.p2.

activity profile for motif LHX3,4.p2


Sorted Z-values histogram for motif LHX3,4.p2

Sorted Z-values for motif LHX3,4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of LHX3,4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_-_13835012 27.834 GPM6B
glycoprotein M6B
chr14_+_92788924 17.284 NM_153648
SLC24A4
solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
chr1_+_155853546 16.849 SYT11
synaptotagmin XI
chr1_+_198608216 15.828 PTPRC
protein tyrosine phosphatase, receptor type, C
chr19_+_9296269 14.001 NM_175883
OR7D2
olfactory receptor, family 7, subfamily D, member 2
chrX_-_13835187 13.802 GPM6B
glycoprotein M6B
chr12_+_75784878 13.204 NM_152436
GLIPR1L2
GLI pathogenesis-related 1 like 2
chr3_-_195310985 13.046 NM_001647
APOD
apolipoprotein D
chr2_+_103089761 12.095 NM_001011552
SLC9A4
solute carrier family 9 (sodium/hydrogen exchanger), member 4
chrX_-_13835313 11.671 NM_001001995
NM_001001996
NM_005278
GPM6B


glycoprotein M6B


chr3_-_195310770 10.760 APOD
apolipoprotein D
chr12_+_8332789 10.509 FAM66C
family with sequence similarity 66, member C
chr12_-_10021932 9.974 CLEC2B
C-type lectin domain family 2, member B
chr3_+_101546833 9.744 NM_001005474
NFKBIZ
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
chr4_-_120243257 8.973 NM_000134
FABP2
fatty acid binding protein 2, intestinal
chr2_-_175462428 8.848 WIPF1
WAS/WASL interacting protein family, member 1
chr12_-_10282680 8.745 NM_022570
NM_197947
NM_197948
NM_197949
NM_197950
NM_197954
CLEC7A





C-type lectin domain family 7, member A





chr10_+_17270257 8.434 NM_003380
VIM
vimentin
chr3_-_69171536 8.392 NM_198271
LMOD3
leiomodin 3 (fetal)
chr5_+_67586466 8.075 NM_181504
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr16_+_2653350 7.951 LOC652276
potassium channel tetramerisation domain containing 5 pseudogene
chr4_+_88896868 7.775 SPP1
secreted phosphoprotein 1
chr1_-_59147727 7.404


chr17_+_28268622 7.360 NM_198529
EFCAB5
EF-hand calcium binding domain 5
chr4_+_88896838 7.305 SPP1
secreted phosphoprotein 1
chr8_-_7212868 7.267 FAM66B
family with sequence similarity 66, member B
chrX_-_15332680 7.181 NM_001012428
ASB11
ankyrin repeat and SOCS box containing 11
chr3_-_18480203 7.025 NM_001131010
SATB1
SATB homeobox 1
chr7_+_23286420 6.812 GPNMB
glycoprotein (transmembrane) nmb
chr5_+_156696351 6.480 NM_014376
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr1_+_198608244 6.441 PTPRC
protein tyrosine phosphatase, receptor type, C
chr4_-_176733901 6.401 GPM6A
glycoprotein M6A
chr7_-_37024664 6.305 NM_001039459
ELMO1
engulfment and cell motility 1
chr4_+_88896899 6.249 SPP1
secreted phosphoprotein 1
chr12_-_9760481 6.092 NM_002258
KLRB1
killer cell lectin-like receptor subfamily B, member 1
chr10_+_102222797 5.971 NM_003393
WNT8B
wingless-type MMTV integration site family, member 8B
chr7_+_23286384 5.918 GPNMB
glycoprotein (transmembrane) nmb
chrX_+_107288199 5.910 NM_001170553
NM_182607
VSIG1

V-set and immunoglobulin domain containing 1

chr16_+_10522724 5.885 NM_024997
ATF7IP2
activating transcription factor 7 interacting protein 2
chr7_+_23286386 5.883 GPNMB
glycoprotein (transmembrane) nmb
chr10_+_17270469 5.879 VIM
vimentin
chr7_-_36764000 5.875 NM_001177506
NM_001177507
NM_001637
AOAH


acyloxyacyl hydrolase (neutrophil)


chr4_-_176733413 5.727 GPM6A
glycoprotein M6A
chr2_+_162272892 5.646 TBR1
T-box, brain, 1
chr5_+_71502700 5.537 MAP1B
microtubule-associated protein 1B
chr11_-_117748200 5.514 NM_001164831
FXYD6
FXYD domain containing ion transport regulator 6
chr19_+_21264952 5.456 NM_182515
ZNF714
zinc finger protein 714
chr6_-_24877453 5.378 NM_015864
FAM65B
family with sequence similarity 65, member B
chr1_-_150738255 5.371 CTSS
cathepsin S
chr5_-_88119604 5.358 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr1_+_198608136 5.303 NM_002838
NM_080921
NM_080923
PTPRC


protein tyrosine phosphatase, receptor type, C


chr4_-_57547845 5.263 NM_001145460
NM_032495
NM_139212
HOPX


HOP homeobox


chr7_+_23286390 5.240 GPNMB
glycoprotein (transmembrane) nmb
chr5_+_67588395 5.192 NM_001242466
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr3_+_122296432 5.086 NM_001113523
PARP15
poly (ADP-ribose) polymerase family, member 15
chr8_-_132052834 5.072 NM_001115
ADCY8
adenylate cyclase 8 (brain)
chr6_+_26440699 5.033 NM_001242803
NM_006994
NM_197974
BTN3A3


butyrophilin, subfamily 3, member A3


chr2_+_90211704 5.027


chr2_-_158300517 4.993 NM_004288
CYTIP
cytohesin 1 interacting protein
chr1_-_150738232 4.922 CTSS
cathepsin S
chr15_+_74421986 4.836 NM_001130137
ISLR2
immunoglobulin superfamily containing leucine-rich repeat 2
chr7_-_38313232 4.811 NM_001003799
NM_001003806
TARP

TRGV9
TCR gamma alternate reading frame protein

T cell receptor gamma variable 9
chr6_+_12717036 4.798 NM_001242648
NM_030948
PHACTR1

phosphatase and actin regulator 1

chr12_-_16760935 4.673 NM_001001395
NM_001243609
LMO3

LIM domain only 3 (rhombotin-like 2)

chr5_-_1882764 4.618 NM_016358
IRX4
iroquois homeobox 4
chr5_+_36606456 4.504 NM_001166696
NM_004172
SLC1A3

solute carrier family 1 (glial high affinity glutamate transporter), member 3

chr8_-_110693233 4.433 NM_001099745
NM_001099746
SYBU

syntabulin (syntaxin-interacting)

chrX_-_13835213 4.373 GPM6B
glycoprotein M6B
chr19_-_51920841 4.343 NM_001171156
NM_001171157
NM_001171158
NM_001171159
NM_001171160
NM_001171161
NM_033130
SIGLEC10






sialic acid binding Ig-like lectin 10






chr4_-_46911223 4.263 NM_130902
COX7B2
cytochrome c oxidase subunit VIIb2
chr12_+_9980076 4.237 NM_016523
KLRF1
killer cell lectin-like receptor subfamily F, member 1
chr4_+_88896801 4.221 NM_000582
NM_001040058
NM_001040060
NM_001251829
NM_001251830
SPP1




secreted phosphoprotein 1




chr1_-_151414641 4.204 NM_207171
POGZ
pogo transposable element with ZNF domain
chr8_-_110661007 4.172 NM_001099747
NM_001099748
NM_001099749
NM_001099750
NM_017786
SYBU




syntabulin (syntaxin-interacting)




chr2_-_175712276 4.157 NM_001206602
CHN1
chimerin (chimaerin) 1
chr12_-_53601051 4.120 ITGB7
integrin, beta 7
chr6_-_33041266 4.074 NM_033554
HLA-DPA1
major histocompatibility complex, class II, DP alpha 1
chr5_+_36606667 4.055 SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr2_+_68961912 4.034 NM_001007231
NM_001166277
ARHGAP25

Rho GTPase activating protein 25

chr12_-_53600999 3.986 NM_000889
ITGB7
integrin, beta 7
chr8_-_102803196 3.968 NCALD
neurocalcin delta
chr1_-_92952429 3.939 NM_005263
GFI1
growth factor independent 1 transcription repressor
chr3_-_105421044 3.901 CBLB
Cas-Br-M (murine) ecotropic retroviral transforming sequence b
chr4_+_78432905 3.880 NM_006419
CXCL13
chemokine (C-X-C motif) ligand 13
chr14_-_106926393 3.805 IGHA1
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr14_+_29241989 3.672 C14orf23
chromosome 14 open reading frame 23
chr14_+_101295409 3.626 MEG3
maternally expressed 3 (non-protein coding)
chr14_-_101036130 3.567 NM_020836
BEGAIN
brain-enriched guanylate kinase-associated homolog (rat)
chr6_+_26402464 3.516 NM_001145008
NM_001145009
NM_007048
NM_194441
BTN3A1



butyrophilin, subfamily 3, member A1



chr4_+_71587674 3.484 NM_001037442
NM_014961
RUFY3

RUN and FYVE domain containing 3

chr5_+_36608430 3.471 NM_001166695
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr5_-_88199868 3.443 NM_001131005
NM_001193347
MEF2C

myocyte enhancer factor 2C

chr3_+_238274 3.434 NM_001253387
NM_006614
CHL1

cell adhesion molecule with homology to L1CAM (close homolog of L1)

chr3_-_114478117 3.432 NM_001164344
NM_001164345
ZBTB20

zinc finger and BTB domain containing 20

chr15_+_25068793 3.380 NM_022806
NM_022807
NM_022808
SNRPN


small nuclear ribonucleoprotein polypeptide N


chr2_+_162272619 3.360 NM_006593
TBR1
T-box, brain, 1
chr8_-_102803178 3.338 NCALD
neurocalcin delta
chr7_-_87342569 3.287 NM_000927
ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr3_-_12941547 3.286 IQSEC1
IQ motif and Sec7 domain 1
chr1_+_177140062 3.270 FAM5B
family with sequence similarity 5, member B
chr13_-_99910548 3.258 NM_001098200
NM_005292
GPR18

G protein-coupled receptor 18

chr8_+_66933790 3.213 NM_033105
DNAJC5B
DnaJ (Hsp40) homolog, subfamily C, member 5 beta
chr15_-_33360084 3.168 NM_001103184
FMN1
formin 1
chr1_+_180601121 3.092 NM_001135669
NM_004736
XPR1

xenotropic and polytropic retrovirus receptor 1

chr1_-_150738292 3.074 NM_001199739
NM_004079
CTSS

cathepsin S

chr19_-_44008984 3.016 NM_198850
PHLDB3
pleckstrin homology-like domain, family B, member 3
chrX_-_72434623 3.004 NAP1L2
nucleosome assembly protein 1-like 2
chrX_-_72434656 3.003 NAP1L2
nucleosome assembly protein 1-like 2
chr1_+_50574589 2.962 NM_001144774
NM_021952
ELAVL4

ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)

chr1_+_50574601 2.934 ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chrX_+_37639246 2.925 NM_000397
CYBB
cytochrome b-245, beta polypeptide
chr7_-_27166638 2.918 NM_153631
HOXA3
homeobox A3
chr3_-_114102488 2.914 NM_001164342
ZBTB20
zinc finger and BTB domain containing 20
chrX_-_72434667 2.909 NM_021963
NAP1L2
nucleosome assembly protein 1-like 2
chr7_+_37723378 2.886


chr11_-_58343308 2.866 NM_004811
LPXN
leupaxin
chr7_+_23286277 2.859 NM_001005340
NM_002510
GPNMB

glycoprotein (transmembrane) nmb

chr2_+_162272800 2.826 TBR1
T-box, brain, 1
chr5_-_160112266 2.811 ATP10B
ATPase, class V, type 10B
chr7_-_14025826 2.750 NM_001163150
NM_001163151
NM_001163152
ETV1


ets variant 1


chr1_+_159259503 2.742 NM_002001
FCER1A
Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
chr12_+_14538232 2.738 ATF7IP
activating transcription factor 7 interacting protein
chr9_-_215892 2.725 NM_152569
C9orf66
chromosome 9 open reading frame 66
chr1_+_168250277 2.695 NM_005149
TBX19
T-box 19
chr12_-_10605928 2.674 NM_002259
NM_007328
KLRC1

killer cell lectin-like receptor subfamily C, member 1

chr20_+_16728997 2.645 NM_020157
OTOR
otoraplin
chr3_+_73110809 2.577 NM_018029
EBLN2
endogenous Bornavirus-like nucleoprotein 2
chr15_+_81489218 2.576 NM_001172128
IL16
interleukin 16
chr10_+_18549583 2.512 NM_000724
CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chr7_-_139763520 2.501 NM_022750
PARP12
poly (ADP-ribose) polymerase family, member 12
chr4_+_39063851 2.490 NM_015990
NM_199039
KLHL5

kelch-like 5 (Drosophila)

chr5_-_22853435 2.490 CDH12
cadherin 12, type 2 (N-cadherin 2)
chr14_-_106733392 2.487 IGHG1
IGHG3
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
chr1_-_89664510 2.482 NM_052941
GBP4
guanylate binding protein 4
chr2_+_169926084 2.457 DHRS9
dehydrogenase/reductase (SDR family) member 9
chr19_-_3557566 2.441 NM_001042680
NM_021731
NM_174983
MFSD12


major facilitator superfamily domain containing 12


chr1_-_217113007 2.440 NM_001243512
NM_001243513
NM_001243510
NM_001243511
ESRRG



estrogen-related receptor gamma



chr17_-_40833840 2.438 NM_016602
CCR10
chemokine (C-C motif) receptor 10
chr7_+_23286401 2.433 GPNMB
glycoprotein (transmembrane) nmb
chr15_+_34261088 2.413 NM_012125
CHRM5
cholinergic receptor, muscarinic 5
chr8_-_27101240 2.399 STMN4
stathmin-like 4
chr2_+_226265601 2.398 NM_020864
NYAP2
neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2
chr1_+_168545710 2.398 NM_002995
XCL1
chemokine (C motif) ligand 1
chr2_-_25391558 2.387 NM_000939
NM_001035256
POMC

proopiomelanocortin

chr6_+_158733691 2.385 NM_001007466
NM_020245
TULP4

tubby like protein 4

chr4_+_62362838 2.383 NM_015236
LPHN3
latrophilin 3
chr7_-_107880492 2.355 NM_001037132
NRCAM
neuronal cell adhesion molecule
chr11_-_102576444 2.328 NM_022122
MMP27
matrix metallopeptidase 27
chr16_-_3627353 2.262 NM_178844
NLRC3
NLR family, CARD domain containing 3
chr1_+_117544371 2.259 NM_004258
CD101
CD101 molecule
chr3_-_12586962 2.244 NM_001195279
LOC100129480
uncharacterized LOC100129480
chrX_+_37639306 2.243 CYBB
cytochrome b-245, beta polypeptide
chr11_+_5710816 2.230 NM_001199573
NM_006074
TRIM22

tripartite motif containing 22

chr11_+_92085261 2.225 NM_001008781
FAT3
FAT tumor suppressor homolog 3 (Drosophila)
chr18_-_53177999 2.223 NM_001243231
TCF4
transcription factor 4
chr1_-_197552304 2.196 DENND1B
DENN/MADD domain containing 1B
chr3_-_52294427 2.195 WDR82
WD repeat domain 82
chr6_+_31553955 2.192 NM_205838
NM_205839
LST1

leukocyte specific transcript 1

chr3_+_141043054 2.188 NM_001080412
ZBTB38
zinc finger and BTB domain containing 38
chr16_-_30934437 2.184 FBXL19-AS1
FBXL19 antisense RNA 1 (non-protein coding)
chr6_-_13408368 2.164 NM_001242630
GFOD1
glucose-fructose oxidoreductase domain containing 1
chr7_-_25268057 2.160 NM_022150
NPVF
neuropeptide VF precursor
chr1_+_244214576 2.157 ZNF238
zinc finger protein 238
chr6_-_133035180 2.138 NM_004666
VNN1
vanin 1
chr20_-_45927496 2.111 ZMYND8
zinc finger, MYND-type containing 8
chr22_+_40297183 2.095 GRAP2
GRB2-related adaptor protein 2
chrX_+_140982451 2.086 NM_177456
MAGEC3
melanoma antigen family C, 3
chr3_-_133648517 2.084 NM_025041
C3orf36
chromosome 3 open reading frame 36
chr6_+_25754926 2.034 NM_005495
SLC17A4
solute carrier family 17 (sodium phosphate), member 4
chr4_+_102734982 2.029 NM_001083907
BANK1
B-cell scaffold protein with ankyrin repeats 1
chr3_+_178276487 2.023 NM_005832
KCNMB2
potassium large conductance calcium-activated channel, subfamily M, beta member 2
chrX_-_62780748 2.014 LOC92249
uncharacterized LOC92249
chrX_-_138724851 2.010 NM_001171877
NM_001171878
NM_001171879
NM_005369
MCF2



MCF.2 cell line derived transforming sequence



chrX_-_15333726 2.003 NM_001201583
NM_080873
ASB11

ankyrin repeat and SOCS box containing 11

chr8_-_102803438 1.988 NM_032041
NCALD
neurocalcin delta
chr3_+_195447751 1.974 NM_152673
MUC20
mucin 20, cell surface associated
chr6_+_31583766 1.956 NM_032955
AIF1
allograft inflammatory factor 1
chr10_-_42863435 1.954 LOC441666
zinc finger protein 91 pseudogene
chr5_-_160279045 1.952 NM_025153
ATP10B
ATPase, class V, type 10B
chr9_+_12693385 1.934 NM_000550
TYRP1
tyrosinase-related protein 1
chr1_+_84630575 1.933 NM_001242860
NM_001242861
PRKACB

protein kinase, cAMP-dependent, catalytic, beta

chr1_+_111413820 1.932 NM_001040033
CD53
CD53 molecule
chr9_-_93405066 1.922 NM_017594
DIRAS2
DIRAS family, GTP-binding RAS-like 2
chr6_-_24583454 1.882 NM_001252328
KIAA0319
KIAA0319
chr2_+_207406815 1.832 ADAM23
ADAM metallopeptidase domain 23
chr6_+_55039070 1.828 NM_001526
HCRTR2
hypocretin (orexin) receptor 2
chr6_+_73076431 1.826 NM_001168411
RIMS1
regulating synaptic membrane exocytosis 1
chr2_-_99279935 1.822 NM_001160154
MGAT4A
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chrX_+_11311532 1.806 NM_001142
NM_182680
NM_182681
AMELX


amelogenin, X-linked


chr14_-_106539099 1.800 IGHA1
IGHG1
IGHG3
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
chr17_-_39623476 1.784 NM_002278
KRT32
keratin 32
chr11_-_89541742 1.781 NM_020358
TRIM49
tripartite motif containing 49
chr1_+_244216506 1.777 NM_006352
ZNF238
zinc finger protein 238
chr22_-_38881529 1.749 DDX17
DEAD (Asp-Glu-Ala-Asp) box polypeptide 17
chr16_-_21663962 1.749 NM_005849
IGSF6
immunoglobulin superfamily, member 6
chr1_+_50569581 1.744 NM_001144776
ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr16_-_21663908 1.743 IGSF6
immunoglobulin superfamily, member 6
chr3_+_171561138 1.740 NM_001164436
TMEM212
transmembrane protein 212
chr1_+_115572414 1.736 NM_000549
TSHB
thyroid stimulating hormone, beta
chr3_+_63953419 1.735 NM_001128149
ATXN7
ataxin 7

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.49 3.11e-06 GO:0023052 signaling
1.93 1.81e-05 GO:0002376 immune system process
2.25 2.30e-05 GO:0006955 immune response
1.30 7.50e-05 GO:0050896 response to stimulus
2.15 1.86e-04 GO:0007267 cell-cell signaling
1.96 2.21e-04 GO:0007154 cell communication
1.44 5.30e-04 GO:0007165 signal transduction
1.31 7.86e-04 GO:0032501 multicellular organismal process
1.21 2.64e-03 GO:0065007 biological regulation
2.07 3.05e-03 GO:0002682 regulation of immune system process
2.22 3.66e-03 GO:0007186 G-protein coupled receptor protein signaling pathway
1.58 3.81e-03 GO:0048583 regulation of response to stimulus
1.96 4.12e-03 GO:0006952 defense response
1.60 4.16e-03 GO:0007166 cell surface receptor linked signaling pathway
1.61 4.18e-03 GO:0003008 system process
2.27 1.34e-02 GO:0050776 regulation of immune response
1.21 1.50e-02 GO:0050794 regulation of cellular process
1.20 1.88e-02 GO:0050789 regulation of biological process
6.67 2.83e-02 GO:0051925 regulation of calcium ion transport via voltage-gated calcium channel activity
1.30 4.50e-02 GO:0051716 cellular response to stimulus

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.41 3.39e-06 GO:0005886 plasma membrane
1.41 3.77e-06 GO:0071944 cell periphery
1.81 5.87e-05 GO:0005887 integral to plasma membrane
1.56 1.08e-04 GO:0044459 plasma membrane part
1.78 1.22e-04 GO:0031226 intrinsic to plasma membrane
1.53 7.70e-04 GO:0005576 extracellular region

Gene overrepresentation in function category:

enrichment   p-value GO term description
7.09 1.51e-02 GO:0004435 phosphatidylinositol phospholipase C activity
10.12 3.14e-02 GO:0005248 voltage-gated sodium channel activity