Motif ID: MAFB.p2

Z-value: 2.331


Transcription factors associated with MAFB.p2:

Gene SymbolEntrez IDGene Name
MAFB 9935 v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
MAFBchr20_-_39317875-0.009.9e-01Click!


Activity profile for motif MAFB.p2.

activity profile for motif MAFB.p2


Sorted Z-values histogram for motif MAFB.p2

Sorted Z-values for motif MAFB.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of MAFB.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr14_-_60337350 63.758 NM_021136
RTN1
reticulon 1
chr14_+_90863365 32.829 CALM1
calmodulin 1 (phosphorylase kinase, delta)
chr20_-_35374530 27.541 NM_022477
NM_032013
NDRG3

NDRG family member 3

chr2_+_30369868 26.690 YPEL5
yippee-like 5 (Drosophila)
chr2_+_30369800 26.201 YPEL5
yippee-like 5 (Drosophila)
chr2_+_30369749 25.285 NM_001127399
NM_001127400
NM_001127401
NM_016061
YPEL5



yippee-like 5 (Drosophila)



chr13_+_98086315 23.340 NM_021033
RAP2A
RAP2A, member of RAS oncogene family
chr2_+_114647683 22.447 ACTR3
ARP3 actin-related protein 3 homolog (yeast)
chr6_+_107811272 21.981 NM_018013
SOBP
sine oculis binding protein homolog (Drosophila)
chr1_+_44870926 21.953 NM_018150
RNF220
ring finger protein 220
chr8_+_24771276 21.829 NEFM
neurofilament, medium polypeptide
chr10_+_111765725 21.680 NM_019903
ADD3
adducin 3 (gamma)
chr19_+_36359346 21.666 NM_001024807
NM_005166
APLP1

amyloid beta (A4) precursor-like protein 1

chr16_+_2039945 20.684 NM_004209
SYNGR3
synaptogyrin 3
chr1_+_87794576 20.250 LMO4
LIM domain only 4
chr2_-_55277421 20.027 RTN4
reticulon 4
chr8_+_104152876 20.027 NM_001024372
NM_024812
BAALC

brain and acute leukemia, cytoplasmic

chr8_+_24771268 19.549 NM_005382
NEFM
neurofilament, medium polypeptide
chr14_-_60097531 19.255 NM_206852
RTN1
reticulon 1
chr2_+_231729661 19.163 ITM2C
integral membrane protein 2C
chr1_-_241520384 18.953 RGS7
regulator of G-protein signaling 7
chr2_+_231729623 18.762 ITM2C
integral membrane protein 2C
chr2_+_114647449 18.582 NM_005721
ACTR3
ARP3 actin-related protein 3 homolog (yeast)
chr2_+_231729501 18.501 NM_001012514
NM_001012516
NM_030926
ITM2C


integral membrane protein 2C


chr11_+_121322848 18.416 NM_003105
SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr1_-_241520467 17.932 NM_002924
RGS7
regulator of G-protein signaling 7
chr4_-_74124305 17.473


chr1_+_51701943 16.873 NM_014372
RNF11
ring finger protein 11
chr2_-_55277459 16.674 RTN4
reticulon 4
chr5_+_139493689 16.378 NM_005859
PURA
purine-rich element binding protein A
chr4_-_83350548 16.368 HNRPDL
heterogeneous nuclear ribonucleoprotein D-like
chr1_+_90286595 16.183 LRRC8D
leucine rich repeat containing 8 family, member D
chr22_+_29876180 16.017 NM_021076
NEFH
neurofilament, heavy polypeptide
chr5_+_17217474 15.311 NM_006317
BASP1
brain abundant, membrane attached signal protein 1
chr1_+_51701995 15.291 RNF11
ring finger protein 11
chr1_+_51701970 14.918 RNF11
ring finger protein 11
chrX_-_154688260 14.798 NM_001007523
NM_001007524
NM_012151
F8A2
F8A3
F8A1
coagulation factor VIII-associated 2
coagulation factor VIII-associated 3
coagulation factor VIII-associated 1
chrX_+_40440229 14.761 ATP6AP2
ATPase, H+ transporting, lysosomal accessory protein 2
chr14_-_60097314 14.656 RTN1
reticulon 1
chr20_-_34330093 14.521 RBM39
RNA binding motif protein 39
chr1_-_32403975 14.507 NM_080391
PTP4A2
protein tyrosine phosphatase type IVA, member 2
chr1_+_90286469 14.120 NM_001134479
LRRC8D
leucine rich repeat containing 8 family, member D
chr1_+_110527307 14.111 AHCYL1
adenosylhomocysteinase-like 1
chr6_+_150070844 13.998 PCMT1
protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr8_-_101964236 13.936 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr2_+_231729638 13.919 ITM2C
integral membrane protein 2C
chr5_-_11904127 13.871 CTNND2
catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)
chr1_-_32403888 13.871 PTP4A2
protein tyrosine phosphatase type IVA, member 2
chr20_-_35374468 13.815 NDRG3
NDRG family member 3
chrX_+_40440145 13.738 NM_005765
ATP6AP2
ATPase, H+ transporting, lysosomal accessory protein 2
chr1_+_87794150 13.595 NM_006769
LMO4
LIM domain only 4
chr4_-_83350829 13.406 HNRPDL
heterogeneous nuclear ribonucleoprotein D-like
chr6_+_150070818 13.197 NM_001252049
NM_001252050
NM_001252051
NM_001252052
NM_001252053
NM_005389
PCMT1





protein-L-isoaspartate (D-aspartate) O-methyltransferase





chr2_+_191745546 13.153 NM_014905
GLS
glutaminase
chr1_+_110527399 13.135 AHCYL1
adenosylhomocysteinase-like 1
chr1_+_110527327 13.112 NM_001242673
NM_006621
AHCYL1

adenosylhomocysteinase-like 1

chrX_+_154114609 13.062 NM_001007523
NM_001007524
NM_012151
F8A2
F8A3
F8A1
coagulation factor VIII-associated 2
coagulation factor VIII-associated 3
coagulation factor VIII-associated 1
chr6_+_150070856 13.020 PCMT1
protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr11_+_63448868 12.986 NM_006054
NM_201428
NM_201429
NM_201430
RTN3



reticulon 3



chr2_+_114647699 12.948 ACTR3
ARP3 actin-related protein 3 homolog (yeast)
chr2_+_191745791 12.894 GLS
glutaminase
chrX_-_13835187 12.883 GPM6B
glycoprotein M6B
chrX_+_40440261 12.847 ATP6AP2
ATPase, H+ transporting, lysosomal accessory protein 2
chr8_-_101964248 12.818 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr8_-_101964197 12.739 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr8_-_101964247 12.699 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr8_-_101964268 12.575 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr4_+_158141735 12.498 NM_000826
NM_001083619
NM_001083620
GRIA2


glutamate receptor, ionotropic, AMPA 2


chrX_-_47479229 12.296 NM_006950
NM_133499
SYN1

synapsin I

chr20_-_34329872 12.257 RBM39
RNA binding motif protein 39
chr1_+_110527418 12.194 AHCYL1
adenosylhomocysteinase-like 1
chr4_-_83350452 12.123 HNRPDL
heterogeneous nuclear ribonucleoprotein D-like
chr1_+_110527432 12.097 AHCYL1
adenosylhomocysteinase-like 1
chr14_-_60097223 12.002 RTN1
reticulon 1
chr8_-_101964258 11.998 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr14_-_23821423 11.850 NM_020372
SLC22A17
solute carrier family 22, member 17
chr3_-_10547340 11.758 ATP2B2
ATPase, Ca++ transporting, plasma membrane 2
chr19_-_59069747 11.707 UBE2M
ubiquitin-conjugating enzyme E2M
chr2_-_74601653 11.706 NM_001135041
NM_023019
DCTN1

dynactin 1

chr2_-_55277592 11.578 RTN4
reticulon 4
chr2_-_55277620 11.563 RTN4
reticulon 4
chr4_+_166299942 11.463 NM_001873
CPE
carboxypeptidase E
chr7_-_150754934 11.407 CDK5
cyclin-dependent kinase 5
chr11_-_10830452 11.364 EIF4G2
eukaryotic translation initiation factor 4 gamma, 2
chr11_+_65658101 11.274 CCDC85B
coiled-coil domain containing 85B
chr4_+_166128769 11.099 NM_007246
KLHL2
kelch-like 2, Mayven (Drosophila)
chrX_-_48693934 11.098 NM_013271
PCSK1N
proprotein convertase subtilisin/kexin type 1 inhibitor
chr1_-_21503352 11.023 NM_001198801
NM_001198802
EIF4G3

eukaryotic translation initiation factor 4 gamma, 3

chr6_-_75994477 11.010 TMEM30A
transmembrane protein 30A
chr20_+_43514350 10.985 YWHAB
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
chr20_-_32699915 10.980 EIF2S2
eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
chr7_-_150754979 10.873 NM_001164410
NM_004935
CDK5

cyclin-dependent kinase 5

chr12_+_7023490 10.833 NM_001975
ENO2
enolase 2 (gamma, neuronal)
chr6_-_75994496 10.720 TMEM30A
transmembrane protein 30A
chr2_+_114647663 10.650 ACTR3
ARP3 actin-related protein 3 homolog (yeast)
chr14_-_23822025 10.626 NM_016609
SLC22A17
solute carrier family 22, member 17
chr1_-_177133818 10.513 ASTN1
astrotactin 1
chr1_-_21503304 10.463 EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr1_+_87794548 10.454 LMO4
LIM domain only 4
chr3_-_33481862 10.415 NM_001128160
NM_014517
UBP1

upstream binding protein 1 (LBP-1a)

chr17_+_34901498 10.373 GGNBP2
gametogenetin binding protein 2
chr14_+_90863302 10.364 NM_006888
CALM1
calmodulin 1 (phosphorylase kinase, delta)
chr7_-_124405029 10.271 GPR37
G protein-coupled receptor 37 (endothelin receptor type B-like)
chr13_+_98086681 10.193 RAP2A
RAP2A, member of RAS oncogene family
chr7_+_106685007 10.120 NM_002736
PRKAR2B
protein kinase, cAMP-dependent, regulatory, type II, beta
chr11_-_10879365 10.116 NM_001143667
NM_021211
ZBED5

zinc finger, BED-type containing 5

chr10_-_75255718 10.065 PPP3CB
protein phosphatase 3, catalytic subunit, beta isozyme
chr10_-_75634219 10.017 NM_001204492
NM_001222
NM_172169
NM_172170
NM_172171
NM_172173
CAMK2G





calcium/calmodulin-dependent protein kinase II gamma





chr11_-_10830299 9.941 EIF4G2
eukaryotic translation initiation factor 4 gamma, 2
chr8_-_101964334 9.894 NM_145690
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chrX_-_13835313 9.827 NM_001001995
NM_001001996
NM_005278
GPM6B


glycoprotein M6B


chr6_+_71377471 9.818 NM_001044305
NM_021940
SMAP1

small ArfGAP 1

chr20_+_1246959 9.816 NM_014723
SNPH
syntaphilin
chrX_-_13835012 9.807 GPM6B
glycoprotein M6B
chr1_+_50574589 9.801 NM_001144774
NM_021952
ELAVL4

ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)

chrX_+_119005789 9.750 NDUFA1
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa
chr6_+_71377584 9.717 SMAP1
small ArfGAP 1
chr22_+_32340592 9.694 YWHAH
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide
chr20_+_57466509 9.669 GNAS
GNAS complex locus
chr2_-_55277653 9.651 RTN4
reticulon 4
chr4_-_15656944 9.612 FBXL5
F-box and leucine-rich repeat protein 5
chr6_-_38670915 9.610 GLO1
glyoxalase I
chr5_+_17217781 9.515 BASP1
brain abundant, membrane attached signal protein 1
chr5_+_140346053 9.444 PCDHAC2
protocadherin alpha subfamily C, 2
chr7_-_150945731 9.438 NM_001003801
SMARCD3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
chr8_+_85095702 9.418 RALYL
RALY RNA binding protein-like
chr6_-_75994631 9.405 NM_001143958
NM_018247
TMEM30A

transmembrane protein 30A

chr7_+_95401817 9.380 NM_001135556
NM_001135557
NM_004411
DYNC1I1


dynein, cytoplasmic 1, intermediate chain 1


chr2_+_198380752 9.299 NM_001100819
NM_015387
MOB4

MOB family member 4, phocein

chr10_-_73848263 9.290 SPOCK2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr9_-_101470836 9.246 NM_005458
GABBR2
gamma-aminobutyric acid (GABA) B receptor, 2
chr9_+_131451847 9.230 SET
SET nuclear oncogene
chr12_+_62860816 9.167 MON2
MON2 homolog (S. cerevisiae)
chr1_+_84944919 9.100 NM_025065
RPF1
ribosome production factor 1 homolog (S. cerevisiae)
chr6_-_38670922 9.031 NM_006708
GLO1
glyoxalase I
chr15_-_59225766 9.011 SLTM
SAFB-like, transcription modulator
chr6_-_84419018 8.996 SNAP91
synaptosomal-associated protein, 91kDa homolog (mouse)
chr10_-_118764559 8.983 KIAA1598
KIAA1598
chrX_+_56589961 8.968 NM_013444
UBQLN2
ubiquilin 2
chrX_-_118827116 8.923 SEPT6
septin 6
chr1_-_245027210 8.921 HNRNPU
heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
chr6_-_38670904 8.915 GLO1
glyoxalase I
chr1_+_111991742 8.891 NM_001688
ATP5F1
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1
chr6_-_84418705 8.857 NM_001242792
SNAP91
synaptosomal-associated protein, 91kDa homolog (mouse)
chr8_+_85095452 8.844 NM_001100392
NM_001100393
RALYL

RALY RNA binding protein-like

chr1_-_177133950 8.833 NM_004319
NM_207108
ASTN1

astrotactin 1

chr4_-_74124456 8.781 NM_032217
NM_198889
ANKRD17

ankyrin repeat domain 17

chr2_+_79740171 8.773 CTNNA2
catenin (cadherin-associated protein), alpha 2
chr16_+_103892 8.766 SNRNP25
small nuclear ribonucleoprotein 25kDa (U11/U12)
chr7_-_140179333 8.763 NM_001145125
NM_013446
MKRN1

makorin ring finger protein 1

chr8_-_102803196 8.702 NCALD
neurocalcin delta
chr1_-_3713048 8.605 NM_020710
LRRC47
leucine rich repeat containing 47
chr3_-_18466759 8.602 NM_001195470
NM_002971
SATB1

SATB homeobox 1

chr1_+_50574601 8.445 ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr16_+_103827 8.421 NM_024571
SNRNP25
small nuclear ribonucleoprotein 25kDa (U11/U12)
chr6_-_38670871 8.421 GLO1
glyoxalase I
chr20_-_34330177 8.379 RBM39
RNA binding motif protein 39
chr1_+_87170222 8.364 NM_001206651
NM_001206652
NM_001206653
NM_016009
SH3GLB1



SH3-domain GRB2-like endophilin B1



chr4_+_166128823 8.336 KLHL2
kelch-like 2, Mayven (Drosophila)
chr4_-_102268333 8.310 PPP3CA
protein phosphatase 3, catalytic subunit, alpha isozyme
chr10_+_111767877 8.299 ADD3
adducin 3 (gamma)
chr16_+_23847271 8.155 NM_002738
NM_212535
PRKCB

protein kinase C, beta

chr3_-_149688638 8.115 NM_002628
NM_053024
PFN2

profilin 2

chr1_+_10270680 8.114 NM_015074
NM_183416
KIF1B

kinesin family member 1B

chr1_-_245027791 8.102 HNRNPU
heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
chr5_-_88199868 8.086 NM_001131005
NM_001193347
MEF2C

myocyte enhancer factor 2C

chrX_+_51486479 8.076 NM_018094
GSPT2
G1 to S phase transition 2
chr6_-_38670882 8.068 GLO1
glyoxalase I
chr12_-_112819755 8.067 NM_001109662
C12orf51
chromosome 12 open reading frame 51
chr17_+_44101549 8.060 MAPT
microtubule-associated protein tau
chr20_+_57466721 8.055 GNAS
GNAS complex locus
chr3_-_45267068 8.004 TMEM158
transmembrane protein 158 (gene/pseudogene)
chr14_+_29236882 7.982 FOXG1
forkhead box G1
chr1_-_35658731 7.977 SFPQ
splicing factor proline/glutamine-rich
chr7_-_766875 7.931 NM_001164760
PRKAR1B
protein kinase, cAMP-dependent, regulatory, type I, beta
chr15_+_80696569 7.914 NM_014862
ARNT2
aryl-hydrocarbon receptor nuclear translocator 2
chr12_-_50297575 7.869 NM_012306
FAIM2
Fas apoptotic inhibitory molecule 2
chr17_+_40610899 7.855 ATP6V0A1
ATPase, H+ transporting, lysosomal V0 subunit a1
chr8_+_56015013 7.854 NM_052898
XKR4
XK, Kell blood group complex subunit-related family, member 4
chr1_+_109792640 7.834 NM_001408
CELSR2
cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)
chr7_-_140179224 7.781 MKRN1
makorin ring finger protein 1
chr11_+_10772781 7.771 NM_014633
CTR9
Ctr9, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
chr2_+_17721806 7.769 NM_003385
VSNL1
visinin-like 1
chr2_+_191745568 7.737 GLS
glutaminase
chr9_-_93405066 7.700 NM_017594
DIRAS2
DIRAS family, GTP-binding RAS-like 2
chrX_+_40944858 7.644 NM_001039590
NM_001039591
USP9X

ubiquitin specific peptidase 9, X-linked

chr8_-_110661007 7.640 NM_001099747
NM_001099748
NM_001099749
NM_001099750
NM_017786
SYBU




syntabulin (syntaxin-interacting)




chr4_-_15656974 7.604 NM_001193534
NM_001193535
NM_012161
FBXL5


F-box and leucine-rich repeat protein 5


chr2_+_159313466 7.590 NM_001005476
NM_003628
PKP4

plakophilin 4

chr10_+_111767685 7.583 NM_001121
NM_016824
ADD3

adducin 3 (gamma)

chr8_+_85095501 7.531 NM_173848
RALYL
RALY RNA binding protein-like
chrX_+_153665258 7.390 NM_001493
GDI1
GDP dissociation inhibitor 1
chr20_-_34330179 7.383 NM_001242599
NM_001242600
NM_004902
NM_184234
RBM39



RNA binding motif protein 39



chr1_+_110527701 7.277 AHCYL1
adenosylhomocysteinase-like 1
chr16_+_23847359 7.262 PRKCB
protein kinase C, beta
chr12_-_25403809 7.261 KRAS
v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
chr2_-_55277672 7.261 RTN4
reticulon 4
chr17_+_40610915 7.225 ATP6V0A1
ATPase, H+ transporting, lysosomal V0 subunit a1
chr4_-_15656895 7.202 FBXL5
F-box and leucine-rich repeat protein 5
chr1_-_115053677 7.160 TRIM33
tripartite motif containing 33

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.22 7.19e-56 GO:0009987 cellular process
1.35 2.57e-38 GO:0044237 cellular metabolic process
1.26 3.10e-25 GO:0008152 metabolic process
1.28 7.72e-25 GO:0044238 primary metabolic process
1.37 1.20e-24 GO:0044260 cellular macromolecule metabolic process
1.48 8.29e-20 GO:0044267 cellular protein metabolic process
1.41 2.20e-19 GO:0034641 cellular nitrogen compound metabolic process
1.39 1.25e-18 GO:0006807 nitrogen compound metabolic process
1.44 1.34e-18 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.28 2.42e-16 GO:0043170 macromolecule metabolic process
2.35 1.40e-15 GO:0009150 purine ribonucleotide metabolic process
1.64 1.53e-15 GO:0051641 cellular localization
2.31 3.24e-15 GO:0009259 ribonucleotide metabolic process
2.38 8.26e-15 GO:0009199 ribonucleoside triphosphate metabolic process
2.35 1.11e-14 GO:0009141 nucleoside triphosphate metabolic process
1.21 1.42e-14 GO:0050794 regulation of cellular process
2.36 2.01e-14 GO:0009205 purine ribonucleoside triphosphate metabolic process
1.18 2.24e-14 GO:0065007 biological regulation
2.11 3.02e-14 GO:0072521 purine-containing compound metabolic process
2.34 4.83e-14 GO:0009144 purine nucleoside triphosphate metabolic process
1.78 8.96e-14 GO:0046907 intracellular transport
1.19 1.34e-13 GO:0050789 regulation of biological process
1.64 1.85e-13 GO:0051649 establishment of localization in cell
2.13 3.14e-13 GO:0006163 purine nucleotide metabolic process
1.43 5.20e-13 GO:0048523 negative regulation of cellular process
2.50 5.59e-13 GO:0009154 purine ribonucleotide catabolic process
1.32 6.97e-13 GO:0051179 localization
2.48 1.07e-12 GO:0009261 ribonucleotide catabolic process
1.91 1.42e-12 GO:0055086 nucleobase, nucleoside and nucleotide metabolic process
2.49 1.89e-12 GO:0009203 ribonucleoside triphosphate catabolic process
2.49 1.89e-12 GO:0009207 purine ribonucleoside triphosphate catabolic process
2.47 1.97e-12 GO:0009143 nucleoside triphosphate catabolic process
2.48 2.62e-12 GO:0009146 purine nucleoside triphosphate catabolic process
2.40 2.97e-12 GO:0006195 purine nucleotide catabolic process
1.40 3.58e-12 GO:0048519 negative regulation of biological process
1.52 4.35e-12 GO:0007399 nervous system development
2.37 5.45e-12 GO:0072523 purine-containing compound catabolic process
1.59 5.82e-12 GO:0044248 cellular catabolic process
1.34 1.14e-11 GO:0019538 protein metabolic process
1.89 1.36e-11 GO:0016071 mRNA metabolic process
1.45 1.87e-11 GO:0006464 protein modification process
1.29 2.57e-11 GO:0023052 signaling
1.91 3.52e-11 GO:0006753 nucleoside phosphate metabolic process
1.91 3.52e-11 GO:0009117 nucleotide metabolic process
2.29 3.98e-11 GO:0009166 nucleotide catabolic process
1.31 4.80e-11 GO:0016043 cellular component organization
1.59 5.89e-11 GO:0008104 protein localization
1.43 6.35e-11 GO:0043412 macromolecule modification
1.30 1.14e-10 GO:0071840 cellular component organization or biogenesis
1.52 1.40e-10 GO:0033036 macromolecule localization
2.20 1.77e-10 GO:0034655 nucleobase, nucleoside, nucleotide and nucleic acid catabolic process
2.20 1.77e-10 GO:0034656 nucleobase, nucleoside and nucleotide catabolic process
1.32 1.79e-10 GO:0051234 establishment of localization
1.49 1.90e-10 GO:0009056 catabolic process
1.59 2.46e-10 GO:0043067 regulation of programmed cell death
1.59 3.21e-10 GO:0042981 regulation of apoptosis
1.32 4.07e-10 GO:0006810 transport
1.58 4.38e-10 GO:0010941 regulation of cell death
1.64 5.60e-10 GO:0045184 establishment of protein localization
2.31 1.05e-09 GO:0048011 nerve growth factor receptor signaling pathway
1.34 1.09e-09 GO:0071842 cellular component organization at cellular level
1.64 1.24e-09 GO:0015031 protein transport
1.58 1.29e-09 GO:0032268 regulation of cellular protein metabolic process
1.63 1.60e-09 GO:0008219 cell death
1.62 2.68e-09 GO:0016265 death
1.32 2.69e-09 GO:0071841 cellular component organization or biogenesis at cellular level
1.83 2.89e-09 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
2.08 4.56e-09 GO:0046700 heterocycle catabolic process
1.42 4.77e-09 GO:0016070 RNA metabolic process
1.54 5.01e-09 GO:0051246 regulation of protein metabolic process
1.71 6.26e-09 GO:0046483 heterocycle metabolic process
1.34 1.08e-08 GO:0048522 positive regulation of cellular process
2.05 1.11e-08 GO:0044270 cellular nitrogen compound catabolic process
1.82 1.36e-08 GO:0019226 transmission of nerve impulse
1.82 1.36e-08 GO:0035637 multicellular organismal signaling
1.40 1.59e-08 GO:0044281 small molecule metabolic process
1.31 2.54e-08 GO:0048518 positive regulation of biological process
1.27 3.43e-08 GO:0007165 signal transduction
1.85 4.57e-08 GO:0007268 synaptic transmission
1.76 5.50e-08 GO:0044282 small molecule catabolic process
2.51 7.47e-08 GO:0006184 GTP catabolic process
2.44 1.11e-07 GO:0046039 GTP metabolic process
1.86 1.20e-07 GO:0051247 positive regulation of protein metabolic process
1.63 1.36e-07 GO:0012501 programmed cell death
1.34 1.73e-07 GO:0090304 nucleic acid metabolic process
1.66 2.20e-07 GO:0007167 enzyme linked receptor protein signaling pathway
1.62 2.59e-07 GO:0006915 apoptosis
1.74 3.00e-07 GO:0070727 cellular macromolecule localization
1.83 7.64e-07 GO:0006091 generation of precursor metabolites and energy
1.59 7.75e-07 GO:0016192 vesicle-mediated transport
1.72 8.15e-07 GO:0034613 cellular protein localization
1.57 9.13e-07 GO:0031399 regulation of protein modification process
2.00 9.60e-07 GO:0015980 energy derivation by oxidation of organic compounds
1.22 1.11e-06 GO:0051716 cellular response to stimulus
1.91 1.79e-06 GO:0006511 ubiquitin-dependent protein catabolic process
1.82 1.80e-06 GO:0032270 positive regulation of cellular protein metabolic process
1.35 2.05e-06 GO:0010467 gene expression
1.87 2.45e-06 GO:0044257 cellular protein catabolic process
1.49 2.50e-06 GO:0006793 phosphorus metabolic process
1.49 2.50e-06 GO:0006796 phosphate metabolic process
1.88 2.73e-06 GO:0070647 protein modification by small protein conjugation or removal
1.69 3.06e-06 GO:0044265 cellular macromolecule catabolic process
1.88 3.39e-06 GO:0043632 modification-dependent macromolecule catabolic process
1.66 3.78e-06 GO:0048666 neuron development
1.83 4.50e-06 GO:0030163 protein catabolic process
1.87 5.44e-06 GO:0019941 modification-dependent protein catabolic process
1.70 5.44e-06 GO:0031175 neuron projection development
1.61 5.66e-06 GO:0006396 RNA processing
1.36 8.14e-06 GO:0023051 regulation of signaling
1.85 9.94e-06 GO:0051603 proteolysis involved in cellular protein catabolic process
1.77 1.24e-05 GO:0006886 intracellular protein transport
1.40 1.28e-05 GO:0035556 intracellular signal transduction
1.49 1.28e-05 GO:0022008 neurogenesis
1.77 1.40e-05 GO:0006397 mRNA processing
1.87 1.61e-05 GO:0008380 RNA splicing
1.47 1.67e-05 GO:0009892 negative regulation of metabolic process
1.59 1.99e-05 GO:0051726 regulation of cell cycle
1.50 2.23e-05 GO:0048699 generation of neurons
1.86 2.31e-05 GO:0031401 positive regulation of protein modification process
1.48 2.53e-05 GO:0031324 negative regulation of cellular metabolic process
1.58 3.20e-05 GO:0030030 cell projection organization
2.19 3.31e-05 GO:0031400 negative regulation of protein modification process
1.48 3.66e-05 GO:0010605 negative regulation of macromolecule metabolic process
1.89 3.69e-05 GO:0032446 protein modification by small protein conjugation
1.64 3.87e-05 GO:0044092 negative regulation of molecular function
1.47 4.32e-05 GO:0048468 cell development
1.58 5.35e-05 GO:0009057 macromolecule catabolic process
1.27 6.02e-05 GO:0044249 cellular biosynthetic process
1.74 6.17e-05 GO:0007264 small GTPase mediated signal transduction
1.54 6.36e-05 GO:0030182 neuron differentiation
2.23 6.56e-05 GO:0031396 regulation of protein ubiquitination
1.41 9.04e-05 GO:0010604 positive regulation of macromolecule metabolic process
1.67 1.14e-04 GO:0048812 neuron projection morphogenesis
1.33 1.19e-04 GO:0006996 organelle organization
1.28 1.21e-04 GO:0065008 regulation of biological quality
2.27 1.27e-04 GO:0046034 ATP metabolic process
1.91 1.66e-04 GO:0032269 negative regulation of cellular protein metabolic process
1.67 1.69e-04 GO:0048667 cell morphogenesis involved in neuron differentiation
1.42 1.71e-04 GO:0022607 cellular component assembly
1.35 1.84e-04 GO:0065009 regulation of molecular function
1.89 1.95e-04 GO:0051248 negative regulation of protein metabolic process
1.85 2.41e-04 GO:0007346 regulation of mitotic cell cycle
1.41 2.62e-04 GO:0010646 regulation of cell communication
1.47 2.66e-04 GO:0051128 regulation of cellular component organization
1.92 2.72e-04 GO:0051129 negative regulation of cellular component organization
1.25 2.77e-04 GO:0009058 biosynthetic process
1.23 2.80e-04 GO:0048731 system development
1.67 3.67e-04 GO:0007409 axonogenesis
1.19 4.06e-04 GO:0019222 regulation of metabolic process
1.36 5.16e-04 GO:0009893 positive regulation of metabolic process
1.60 5.58e-04 GO:0000904 cell morphogenesis involved in differentiation
1.20 5.63e-04 GO:0031323 regulation of cellular metabolic process
2.32 5.74e-04 GO:0031398 positive regulation of protein ubiquitination
1.37 6.28e-04 GO:0044085 cellular component biogenesis
1.64 8.15e-04 GO:0043086 negative regulation of catalytic activity
2.21 9.01e-04 GO:0045333 cellular respiration
1.82 1.07e-03 GO:0016567 protein ubiquitination
2.90 1.17e-03 GO:0006521 regulation of cellular amino acid metabolic process
1.58 1.29e-03 GO:0032990 cell part morphogenesis
2.43 1.37e-03 GO:0031397 negative regulation of protein ubiquitination
1.58 1.47e-03 GO:0048858 cell projection morphogenesis
1.66 2.20e-03 GO:0044271 cellular nitrogen compound biosynthetic process
1.20 2.68e-03 GO:0048856 anatomical structure development
1.43 2.81e-03 GO:0016310 phosphorylation
1.89 2.82e-03 GO:0000375 RNA splicing, via transesterification reactions
1.92 2.87e-03 GO:0034404 nucleobase, nucleoside and nucleotide biosynthetic process
1.92 2.87e-03 GO:0034654 nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process
1.70 2.94e-03 GO:0033043 regulation of organelle organization
1.47 2.99e-03 GO:0065003 macromolecular complex assembly
1.19 3.26e-03 GO:0060255 regulation of macromolecule metabolic process
2.42 3.34e-03 GO:0051351 positive regulation of ligase activity
2.32 3.36e-03 GO:0009152 purine ribonucleotide biosynthetic process
2.32 3.36e-03 GO:0051340 regulation of ligase activity
2.07 3.40e-03 GO:0072522 purine-containing compound biosynthetic process
1.35 3.55e-03 GO:0050790 regulation of catalytic activity
2.00 3.78e-03 GO:0010498 proteasomal protein catabolic process
2.00 3.78e-03 GO:0043161 proteasomal ubiquitin-dependent protein catabolic process
1.87 4.07e-03 GO:0006605 protein targeting
1.46 4.20e-03 GO:0019220 regulation of phosphate metabolic process
1.46 4.20e-03 GO:0051174 regulation of phosphorus metabolic process
2.24 4.21e-03 GO:0009260 ribonucleotide biosynthetic process
1.88 4.53e-03 GO:0006457 protein folding
2.60 5.08e-03 GO:0033238 regulation of cellular amine metabolic process
1.34 5.08e-03 GO:0031325 positive regulation of cellular metabolic process
1.68 5.17e-03 GO:0032535 regulation of cellular component size
1.67 5.94e-03 GO:0007411 axon guidance
1.88 6.06e-03 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
1.88 6.06e-03 GO:0000398 nuclear mRNA splicing, via spliceosome
1.43 7.55e-03 GO:0071844 cellular component assembly at cellular level
1.18 9.29e-03 GO:0080090 regulation of primary metabolic process
1.93 9.41e-03 GO:0009165 nucleotide biosynthetic process
1.63 1.04e-02 GO:0012502 induction of programmed cell death
1.62 1.04e-02 GO:0016568 chromatin modification
2.28 1.07e-02 GO:0051438 regulation of ubiquitin-protein ligase activity
2.38 1.10e-02 GO:0051443 positive regulation of ubiquitin-protein ligase activity
1.49 1.13e-02 GO:0050878 regulation of body fluid levels
1.42 1.13e-02 GO:0007267 cell-cell signaling
1.53 1.20e-02 GO:0007596 blood coagulation
1.53 1.20e-02 GO:0050817 coagulation
1.52 1.26e-02 GO:0043068 positive regulation of programmed cell death
1.71 1.32e-02 GO:0010608 posttranscriptional regulation of gene expression
1.48 1.37e-02 GO:0000902 cell morphogenesis
2.05 1.42e-02 GO:0006164 purine nucleotide biosynthetic process
1.89 1.49e-02 GO:0006913 nucleocytoplasmic transport
1.89 1.49e-02 GO:0032869 cellular response to insulin stimulus
1.52 1.65e-02 GO:0007599 hemostasis
1.50 1.69e-02 GO:0010942 positive regulation of cell death
1.22 1.70e-02 GO:0006950 response to stress
1.26 1.72e-02 GO:0007166 cell surface receptor linked signaling pathway
1.61 1.73e-02 GO:0044419 interspecies interaction between organisms
1.62 1.73e-02 GO:0006917 induction of apoptosis
2.23 1.83e-02 GO:0022904 respiratory electron transport chain
2.45 1.95e-02 GO:0006200 ATP catabolic process
1.86 2.15e-02 GO:0051169 nuclear transport
1.52 2.24e-02 GO:0006325 chromatin organization
1.43 2.45e-02 GO:0042325 regulation of phosphorylation
4.15 2.48e-02 GO:0035336 long-chain fatty-acyl-CoA metabolic process
4.15 2.48e-02 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process
1.99 2.48e-02 GO:0048193 Golgi vesicle transport
2.33 2.67e-02 GO:0009142 nucleoside triphosphate biosynthetic process
1.50 2.72e-02 GO:0043065 positive regulation of apoptosis
2.02 2.96e-02 GO:0007093 mitotic cell cycle checkpoint
1.23 3.08e-02 GO:0030154 cell differentiation
1.54 3.09e-02 GO:0043069 negative regulation of programmed cell death
1.50 3.22e-02 GO:0070271 protein complex biogenesis
1.75 3.23e-02 GO:0071375 cellular response to peptide hormone stimulus
2.27 3.46e-02 GO:2000045 regulation of G1/S transition of mitotic cell cycle
2.05 3.50e-02 GO:0043254 regulation of protein complex assembly
1.53 3.50e-02 GO:0043066 negative regulation of apoptosis
2.34 3.60e-02 GO:0032271 regulation of protein polymerization
2.38 3.61e-02 GO:0051352 negative regulation of ligase activity
2.38 3.61e-02 GO:0051444 negative regulation of ubiquitin-protein ligase activity
1.52 3.70e-02 GO:0060548 negative regulation of cell death
1.28 3.84e-02 GO:0009966 regulation of signal transduction
1.58 4.03e-02 GO:0090066 regulation of anatomical structure size
1.50 4.04e-02 GO:0006461 protein complex assembly
1.45 4.22e-02 GO:0042060 wound healing
1.37 4.40e-02 GO:0043933 macromolecular complex subunit organization
1.43 4.63e-02 GO:0032989 cellular component morphogenesis
1.49 4.72e-02 GO:0044283 small molecule biosynthetic process
1.60 4.74e-02 GO:0071495 cellular response to endogenous stimulus
2.31 4.79e-02 GO:0009201 ribonucleoside triphosphate biosynthetic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.30 1.09e-51 GO:0005737 cytoplasm
1.19 1.05e-45 GO:0005622 intracellular
1.19 4.68e-45 GO:0044424 intracellular part
1.33 3.21e-33 GO:0044444 cytoplasmic part
1.20 7.15e-24 GO:0043227 membrane-bounded organelle
1.20 1.49e-23 GO:0043231 intracellular membrane-bounded organelle
1.17 5.41e-23 GO:0043226 organelle
1.17 7.00e-23 GO:0043229 intracellular organelle
1.54 1.37e-21 GO:0005829 cytosol
1.38 1.63e-20 GO:0032991 macromolecular complex
1.42 3.52e-20 GO:0043234 protein complex
1.27 6.94e-20 GO:0044446 intracellular organelle part
1.27 1.34e-19 GO:0044422 organelle part
1.06 2.23e-12 GO:0044464 cell part
1.06 2.39e-12 GO:0005623 cell
1.37 1.56e-10 GO:0044428 nuclear part
1.19 6.32e-09 GO:0005634 nucleus
1.32 8.77e-08 GO:0070013 intracellular organelle lumen
1.31 1.09e-07 GO:0031974 membrane-enclosed lumen
1.32 2.41e-07 GO:0031090 organelle membrane
1.30 3.22e-07 GO:0043233 organelle lumen
1.34 6.58e-07 GO:0031981 nuclear lumen
1.40 1.21e-06 GO:0005654 nucleoplasm
1.76 1.28e-06 GO:0043005 neuron projection
1.43 1.71e-06 GO:0000267 cell fraction
2.15 1.84e-06 GO:0030424 axon
1.53 5.31e-06 GO:0016023 cytoplasmic membrane-bounded vesicle
1.52 7.04e-06 GO:0031988 membrane-bounded vesicle
2.35 8.89e-06 GO:0044455 mitochondrial membrane part
1.78 1.02e-05 GO:0005625 soluble fraction
1.70 1.15e-05 GO:0045202 synapse
1.66 1.69e-05 GO:0005768 endosome
1.49 1.81e-05 GO:0031410 cytoplasmic vesicle
2.46 2.04e-05 GO:0019717 synaptosome
1.48 2.42e-05 GO:0031982 vesicle
2.85 3.28e-05 GO:0000502 proteasome complex
1.50 4.55e-05 GO:0031967 organelle envelope
1.41 8.21e-05 GO:0005794 Golgi apparatus
1.48 8.95e-05 GO:0031975 envelope
2.72 1.10e-04 GO:0030427 site of polarized growth
1.53 1.42e-04 GO:0044431 Golgi apparatus part
1.87 1.49e-04 GO:0016604 nuclear body
2.71 2.07e-04 GO:0030426 growth cone
1.67 2.69e-04 GO:0048471 perinuclear region of cytoplasm
1.57 3.39e-04 GO:0000139 Golgi membrane
1.45 5.54e-04 GO:0044451 nucleoplasm part
1.29 5.95e-04 GO:0012505 endomembrane system
2.33 7.27e-04 GO:0016585 chromatin remodeling complex
2.45 9.57e-04 GO:0033267 axon part
1.40 1.28e-03 GO:0005626 insoluble fraction
1.44 1.55e-03 GO:0015630 microtubule cytoskeleton
1.20 2.37e-03 GO:0043228 non-membrane-bounded organelle
1.20 2.37e-03 GO:0043232 intracellular non-membrane-bounded organelle
1.71 3.08e-03 GO:0010008 endosome membrane
2.23 3.98e-03 GO:0042470 melanosome
2.23 3.98e-03 GO:0048770 pigment granule
1.70 4.12e-03 GO:0044440 endosomal part
1.81 4.93e-03 GO:0030425 dendrite
1.37 5.64e-03 GO:0005624 membrane fraction
1.29 6.34e-03 GO:0005739 mitochondrion
1.49 1.12e-02 GO:0005740 mitochondrial envelope
1.91 1.46e-02 GO:0005681 spliceosomal complex
1.48 1.71e-02 GO:0044427 chromosomal part
1.43 1.73e-02 GO:0005694 chromosome
2.68 2.09e-02 GO:0016469 proton-transporting two-sector ATPase complex
1.48 2.30e-02 GO:0031966 mitochondrial membrane
1.61 2.39e-02 GO:0012506 vesicle membrane
1.38 2.39e-02 GO:0044429 mitochondrial part
1.62 2.71e-02 GO:0030659 cytoplasmic vesicle membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.38 6.06e-64 GO:0005515 protein binding
1.15 2.59e-30 GO:0005488 binding
1.51 7.34e-22 GO:0000166 nucleotide binding
1.49 1.99e-16 GO:0017076 purine nucleotide binding
1.50 2.14e-16 GO:0032553 ribonucleotide binding
1.50 2.14e-16 GO:0032555 purine ribonucleotide binding
1.49 9.09e-16 GO:0035639 purine ribonucleoside triphosphate binding
1.45 2.67e-10 GO:0030554 adenyl nucleotide binding
1.45 3.47e-10 GO:0032559 adenyl ribonucleotide binding
1.43 2.46e-09 GO:0005524 ATP binding
1.62 3.97e-09 GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
1.61 5.14e-09 GO:0016462 pyrophosphatase activity
1.61 5.81e-09 GO:0016817 hydrolase activity, acting on acid anhydrides
1.19 1.29e-08 GO:0003824 catalytic activity
1.61 1.46e-08 GO:0017111 nucleoside-triphosphatase activity
1.61 1.89e-08 GO:0019899 enzyme binding
1.57 3.51e-08 GO:0003723 RNA binding
2.15 1.54e-07 GO:0003924 GTPase activity
1.69 3.81e-06 GO:0016874 ligase activity
1.67 2.15e-05 GO:0019904 protein domain specific binding
1.59 2.85e-05 GO:0008092 cytoskeletal protein binding
1.72 5.10e-05 GO:0005525 GTP binding
1.68 1.23e-04 GO:0019001 guanyl nucleotide binding
1.68 1.23e-04 GO:0032561 guanyl ribonucleotide binding
2.19 7.77e-04 GO:0015631 tubulin binding
2.51 2.07e-03 GO:0042625 ATPase activity, coupled to transmembrane movement of ions
2.44 3.94e-03 GO:0008017 microtubule binding
2.26 6.94e-03 GO:0008565 protein transporter activity
1.64 8.75e-03 GO:0016879 ligase activity, forming carbon-nitrogen bonds
1.57 1.77e-02 GO:0016887 ATPase activity
1.65 1.85e-02 GO:0016881 acid-amino acid ligase activity
1.20 2.18e-02 GO:0016787 hydrolase activity
1.76 2.78e-02 GO:0003682 chromatin binding
2.00 3.60e-02 GO:0015399 primary active transmembrane transporter activity
2.00 3.60e-02 GO:0015405 P-P-bond-hydrolysis-driven transmembrane transporter activity