Motif ID: MTF1.p2

Z-value: 2.864


Transcription factors associated with MTF1.p2:

Gene SymbolEntrez IDGene Name
MTF1 4520 metal-regulatory transcription factor 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
MTF1chr1_-_38325224-0.252.4e-04Click!


Activity profile for motif MTF1.p2.

activity profile for motif MTF1.p2


Sorted Z-values histogram for motif MTF1.p2

Sorted Z-values for motif MTF1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of MTF1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_-_101459410 72.523


chr5_-_11904127 68.544 CTNND2
catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)
chr16_+_58497548 63.712 NM_020465
NDRG4
NDRG family member 4
chr7_+_64498643 63.413 CCT6P3
chaperonin containing TCP1, subunit 6 (zeta) pseudogene 3
chr16_+_56659679 57.084 MT1E
metallothionein 1E
chr1_+_104068312 54.397 RNPC3
RNA-binding region (RNP1, RRM) containing 3
chr16_+_56659584 54.147 NM_175617
MT1E
metallothionein 1E
chr5_-_11903964 53.820 NM_001332
CTNND2
catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)
chr16_+_58497628 44.828 NDRG4
NDRG family member 4
chr16_+_56703725 44.306 NM_005951
MT1H
metallothionein 1H
chr1_-_32229635 41.177 NM_001703
BAI2
brain-specific angiogenesis inhibitor 2
chr10_+_124220990 38.777 NM_002775
HTRA1
HtrA serine peptidase 1
chr16_+_58497993 38.529 NM_001130487
NDRG4
NDRG family member 4
chr16_+_56623266 37.837 NM_005954
MT3
metallothionein 3
chr20_-_3154169 37.260 ProSAPiP1
ProSAPiP1 protein
chr19_+_33685489 36.157 NM_002333
LRP3
low density lipoprotein receptor-related protein 3
chr9_-_139922705 35.089 NM_001606
ABCA2
ATP-binding cassette, sub-family A (ABC1), member 2
chr15_-_29862926 34.857 NM_015307
FAM189A1
family with sequence similarity 189, member A1
chr7_-_994008 34.560 ADAP1
ArfGAP with dual PH domains 1
chr16_+_56666533 33.748 NM_176870
MT1M
metallothionein 1M
chr7_-_44365019 33.704 NM_001220
NM_172078
NM_172079
NM_172080
NM_172081
NM_172082
NM_172083
NM_172084
CAMK2B







calcium/calmodulin-dependent protein kinase II beta







chr6_+_89855745 31.327 NM_001010853
PM20D2
peptidase M20 domain containing 2
chr9_+_133320247 31.251 ASS1
argininosuccinate synthase 1
chr16_+_56642477 30.917 NM_005953
MT2A
metallothionein 2A
chr13_+_27131799 30.733 NM_006646
WASF3
WAS protein family, member 3
chr4_+_187112936 30.494 CYP4V2
cytochrome P450, family 4, subfamily V, polypeptide 2
chr20_+_20348744 30.234 NM_002196
INSM1
insulinoma-associated 1
chr11_+_125774271 30.142 NM_013264
DDX25
DEAD (Asp-Glu-Ala-Asp) box polypeptide 25
chr8_-_110704019 29.999 NM_001099743
NM_001099744
SYBU

syntabulin (syntaxin-interacting)

chr9_-_139922595 29.630 ABCA2
ATP-binding cassette, sub-family A (ABC1), member 2
chr6_+_35227234 29.579 ZNF76
zinc finger protein 76
chr19_-_5340700 28.953 NM_002850
NM_130853
NM_130854
NM_130855
PTPRS



protein tyrosine phosphatase, receptor type, S



chr2_-_97303983 28.605 KANSL3
KAT8 regulatory NSL complex subunit 3
chr14_-_81687574 28.457 NM_201595
GTF2A1
general transcription factor IIA, 1, 19/37kDa
chr19_+_33685140 28.018 LRP3
low density lipoprotein receptor-related protein 3
chr12_+_48499655 27.533 NM_001166686
PFKM
phosphofructokinase, muscle
chr9_+_133320093 27.372 NM_000050
NM_054012
ASS1

argininosuccinate synthase 1

chr19_-_36523540 27.335 NM_001199570
CLIP3
CAP-GLY domain containing linker protein 3
chr7_+_86273951 27.309 GRM3
glutamate receptor, metabotropic 3
chr11_-_12030128 26.686 NM_001018057
DKK3
dickkopf 3 homolog (Xenopus laevis)
chr13_-_80915041 26.679 NM_005842
SPRY2
sprouty homolog 2 (Drosophila)
chr14_-_81687265 26.602 NM_015859
GTF2A1
general transcription factor IIA, 1, 19/37kDa
chr2_+_20646831 26.543 NM_004040
RHOB
ras homolog gene family, member B
chr17_-_5404304 25.929 NM_001162371
LOC728392
uncharacterized LOC728392
chr10_-_118501981 25.896 NM_025015
HSPA12A
heat shock 70kDa protein 12A
chr16_-_56701904 25.688 NM_005950
MT1G
metallothionein 1G
chr9_+_34958320 25.683 KIAA1045
KIAA1045
chr16_+_56716378 25.185 NM_005952
MT1X
metallothionein 1X
chr12_-_45270157 24.812 NM_001145108
NM_006159
NELL2

NEL-like 2 (chicken)

chr19_-_36523770 24.634 NM_015526
CLIP3
CAP-GLY domain containing linker protein 3
chr1_-_184723952 24.543 EDEM3
ER degradation enhancer, mannosidase alpha-like 3
chr8_+_136469557 24.434 NM_006558
KHDRBS3
KH domain containing, RNA binding, signal transduction associated 3
chr3_-_183543295 24.406 NM_024871
MAP6D1
MAP6 domain containing 1
chrX_-_13956445 24.280


chr15_+_101459459 24.039 NM_024652
LRRK1
leucine-rich repeat kinase 1
chr16_+_56691854 23.713 NM_005949
MT1F
metallothionein 1F
chr2_+_236403290 23.575 AGAP1
ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
chr3_+_71803200 23.509 NM_018971
GPR27
G protein-coupled receptor 27
chr15_+_80696569 23.090 NM_014862
ARNT2
aryl-hydrocarbon receptor nuclear translocator 2
chr14_+_96505566 23.076 NM_001252507
C14orf132
chromosome 14 open reading frame 132
chr6_+_7590405 22.884 NM_152551
SNRNP48
small nuclear ribonucleoprotein 48kDa (U11/U12)
chr7_+_86274076 22.696 GRM3
glutamate receptor, metabotropic 3
chr9_+_137979513 22.392 OLFM1
olfactomedin 1
chr7_-_994259 22.367 NM_006869
ADAP1
ArfGAP with dual PH domains 1
chr20_-_62130390 22.292 NM_001958
EEF1A2
eukaryotic translation elongation factor 1 alpha 2
chr19_-_49944613 22.241 NM_020309
SLC17A7
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7
chr2_-_97304060 22.147 KANSL3
KAT8 regulatory NSL complex subunit 3
chr20_-_55841090 21.802 BMP7
bone morphogenetic protein 7
chr3_+_133465098 21.721 TF
transferrin
chrX_-_102319080 21.412 BEX1
brain expressed, X-linked 1
chr16_+_56225301 21.325 GNAO1
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
chr22_+_19701968 21.320 NM_002688
SEPT5
septin 5
chr4_-_109684053 21.200 NM_001146590
NM_001146627
NM_031279
AGXT2L1


alanine-glyoxylate aminotransferase 2-like 1


chr7_+_86273867 21.162 GRM3
glutamate receptor, metabotropic 3
chr11_-_2906960 21.119 NM_000076
NM_001122630
NM_001122631
CDKN1C


cyclin-dependent kinase inhibitor 1C (p57, Kip2)


chr16_+_84002099 21.029 NM_019065
NECAB2
N-terminal EF-hand calcium binding protein 2
chrX_-_102319096 20.611 NM_018476
BEX1
brain expressed, X-linked 1
chr2_-_97304080 20.600 NM_001115016
NM_017991
KANSL3

KAT8 regulatory NSL complex subunit 3

chr8_-_121824268 20.488 SNTB1
syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
chr2_+_170590454 20.478 KLHL23
kelch-like 23 (Drosophila)
chrX_+_135229536 20.473 NM_001159702
NM_001159703
NM_001449
FHL1


four and a half LIM domains 1


chr8_-_121824287 20.454 NM_021021
SNTB1
syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
chr9_+_34958171 20.403 NM_015297
KIAA1045
KIAA1045
chr1_-_241520384 20.312 RGS7
regulator of G-protein signaling 7
chr15_+_76352323 20.249 C15orf27
chromosome 15 open reading frame 27
chr15_+_74422920 20.219 ISLR2
immunoglobulin superfamily containing leucine-rich repeat 2
chr12_-_54982271 20.180 NM_006741
PPP1R1A
protein phosphatase 1, regulatory (inhibitor) subunit 1A
chr8_-_121824015 20.173


chr12_+_57610577 20.095 NM_007224
NXPH4
neurexophilin 4
chr19_+_708766 20.018 NM_001040134
NM_002579
PALM

paralemmin

chr3_-_52001388 19.977 NM_020418
NM_001174100
NM_033008
PCBP4


poly(rC) binding protein 4


chr6_+_35227478 19.835 NM_003427
ZNF76
zinc finger protein 76
chr18_-_5543967 19.785 NM_012307
EPB41L3
erythrocyte membrane protein band 4.1-like 3
chr22_+_38035718 19.647 SH3BP1
SH3-domain binding protein 1
chr22_+_51039178 19.565 MAPK8IP2
mitogen-activated protein kinase 8 interacting protein 2
chr6_+_7108864 19.453 RREB1
ras responsive element binding protein 1
chr20_+_34742656 19.335 NM_012156
EPB41L1
erythrocyte membrane protein band 4.1-like 1
chr1_-_201476248 19.323 NM_001193570
NM_004078
CSRP1

cysteine and glycine-rich protein 1

chr15_+_74422742 19.293 NM_020851
ISLR2
immunoglobulin superfamily containing leucine-rich repeat 2
chr7_-_158622184 19.272 ESYT2
extended synaptotagmin-like protein 2
chr19_+_38755097 19.187 NM_001166103
NM_021102
SPINT2

serine peptidase inhibitor, Kunitz type, 2

chr4_+_187112635 19.172 NM_207352
CYP4V2
cytochrome P450, family 4, subfamily V, polypeptide 2
chr3_+_133465250 19.153 TF
transferrin
chr16_+_56672577 19.018 NM_005946
MT1A
metallothionein 1A
chr19_+_40697516 19.016 NM_002446
MAP3K10
mitogen-activated protein kinase kinase kinase 10
chr4_+_187065994 18.998 NM_015398
FAM149A
family with sequence similarity 149, member A
chr10_-_61469322 18.944 NM_194298
LOC100129721
SLC16A9
uncharacterized LOC100129721
solute carrier family 16, member 9 (monocarboxylic acid transporter 9)
chr12_-_45269953 18.926 NELL2
NEL-like 2 (chicken)
chr22_+_21986968 18.809 NM_152612
CCDC116
coiled-coil domain containing 116
chr8_-_26371387 18.790 NM_007257
PNMA2
paraneoplastic antigen MA2
chr17_+_30813928 18.694 NM_003885
CDK5R1
cyclin-dependent kinase 5, regulatory subunit 1 (p35)
chr8_+_26371461 18.688 NM_001197293
DPYSL2
dihydropyrimidinase-like 2
chr13_-_45150601 18.579 NM_001243799
NM_183422
TSC22D1

TSC22 domain family, member 1

chr12_+_112204690 18.546 NM_000690
NM_001204889
ALDH2

aldehyde dehydrogenase 2 family (mitochondrial)

chr1_+_151254740 18.530 NM_020832
ZNF687
zinc finger protein 687
chr20_+_44034632 18.411 NM_001197139
NM_001048221
NM_001048222
NM_001197140
NM_018478
DBNDD2




dysbindin (dystrobrevin binding protein 1) domain containing 2




chr2_+_219824346 18.395 NM_003936
CDK5R2
cyclin-dependent kinase 5, regulatory subunit 2 (p39)
chr9_+_140772228 18.368 NM_000718
NM_001243812
CACNA1B

calcium channel, voltage-dependent, N type, alpha 1B subunit

chr22_-_51021200 18.316 CHKB
choline kinase beta
chr13_-_29069215 18.264 NM_001159920
NM_001160030
NM_001160031
NM_002019
FLT1



fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)



chr19_-_57352055 18.216 NM_001146326
NM_001146327
NM_015363
NM_001146184
NM_001146185
NM_001146187
NM_006210
ZIM2


PEG3



zinc finger, imprinted 2


paternally expressed 3



chr9_+_137967401 18.196 OLFM1
olfactomedin 1
chr2_+_26915390 18.168 NM_002246
KCNK3
potassium channel, subfamily K, member 3
chr7_-_97881436 18.145 NM_015395
TECPR1
tectonin beta-propeller repeat containing 1
chr9_-_93405066 18.004 NM_017594
DIRAS2
DIRAS family, GTP-binding RAS-like 2
chr11_-_117747618 17.851 NM_001204268
NM_001243598
NM_001164832
NM_001164836
NM_001164837
NM_022003
FXYD6-FXYD2

FXYD6



FXYD6-FXYD2 readthrough

FXYD domain containing ion transport regulator 6



chr3_+_133465204 17.811 TF
transferrin
chr17_-_71308118 17.806 NM_012121
CDC42EP4
CDC42 effector protein (Rho GTPase binding) 4
chr16_+_89894853 17.797 NM_032451
SPIRE2
spire homolog 2 (Drosophila)
chr18_-_21851816 17.787 OSBPL1A
oxysterol binding protein-like 1A
chr1_-_201476241 17.638 CSRP1
cysteine and glycine-rich protein 1
chr2_+_236402948 17.497 AGAP1
ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
chr2_+_207308280 17.443 NM_003812
ADAM23
ADAM metallopeptidase domain 23
chr19_+_16222706 17.392 RAB8A
RAB8A, member RAS oncogene family
chr9_+_137967366 17.385 OLFM1
olfactomedin 1
chr1_-_11714738 17.340 NM_012168
FBXO2
F-box protein 2
chr3_-_10749715 17.162 ATP2B2
ATPase, Ca++ transporting, plasma membrane 2
chr17_+_74733468 17.156 NM_001242532
NM_001242533
NM_001242535
NM_001242536
NM_001242537
NM_024311
MFSD11





major facilitator superfamily domain containing 11





chr2_+_241507928 17.155 NM_018226
RNPEPL1
arginyl aminopeptidase (aminopeptidase B)-like 1
chr1_-_201476218 17.110 CSRP1
cysteine and glycine-rich protein 1
chr22_-_29711474 17.038 RASL10A
RAS-like, family 10, member A
chrX_-_140271275 16.934 LDOC1
leucine zipper, down-regulated in cancer 1
chr17_-_37307814 16.917 PLXDC1
plexin domain containing 1
chr19_+_36266366 16.828 NM_001172630
NM_052948
ARHGAP33

Rho GTPase activating protein 33

chr19_-_42746743 16.805 GSK3A
glycogen synthase kinase 3 alpha
chr22_-_51021255 16.666 CHKB
choline kinase beta
chr22_+_26565623 16.658 SEZ6L
seizure related 6 homolog (mouse)-like
chr2_+_241938254 16.624 NM_001080437
SNED1
sushi, nidogen and EGF-like domains 1
chr10_-_75634219 16.601 NM_001204492
NM_001222
NM_172169
NM_172170
NM_172171
NM_172173
CAMK2G





calcium/calmodulin-dependent protein kinase II gamma





chr19_+_38893828 16.433 FAM98C
family with sequence similarity 98, member C
chr1_+_77747727 16.427 AK5
adenylate kinase 5
chr7_+_142552547 16.422 NM_004445
EPHB6
EPH receptor B6
chr5_+_65892139 16.387 NM_001164664
NM_198828
MAST4

microtubule associated serine/threonine kinase family member 4

chr11_+_45868956 16.384 NM_021117
CRY2
cryptochrome 2 (photolyase-like)
chr22_-_31741761 16.366 PATZ1
POZ (BTB) and AT hook containing zinc finger 1
chr4_+_3768104 16.350 ADRA2C
adrenergic, alpha-2C-, receptor
chr16_+_1203240 16.229 NM_001005407
NM_021098
CACNA1H

calcium channel, voltage-dependent, T type, alpha 1H subunit

chr22_+_43808011 16.221 NM_001044370
MPPED1
metallophosphoesterase domain containing 1
chr1_+_4715104 16.215 NM_001042478
NM_018836
AJAP1

adherens junctions associated protein 1

chr6_-_46459010 16.176 NM_001251974
RCAN2
regulator of calcineurin 2
chr15_+_68871285 16.152 NM_006091
CORO2B
coronin, actin binding protein, 2B
chr13_-_36705432 15.957 DCLK1
doublecortin-like kinase 1
chr9_-_80646150 15.917 NM_002072
GNAQ
guanine nucleotide binding protein (G protein), q polypeptide
chr4_-_5890142 15.902 CRMP1
collapsin response mediator protein 1
chr20_-_32274070 15.898 E2F1
E2F transcription factor 1
chr1_-_201475966 15.835 NM_001193571
CSRP1
cysteine and glycine-rich protein 1
chr12_-_93964636 15.809


chr7_-_158622202 15.779 NM_020728
ESYT2
extended synaptotagmin-like protein 2
chr2_-_224903933 15.671 NM_001136528
NM_006216
SERPINE2

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2

chr1_+_1981902 15.601 NM_002744
PRKCZ
protein kinase C, zeta
chr9_+_130374466 15.570 NM_001032221
NM_003165
STXBP1

syntaxin binding protein 1

chr19_-_13617037 15.537 NM_000068
NM_001127221
NM_001127222
NM_001174080
NM_023035
CACNA1A




calcium channel, voltage-dependent, P/Q type, alpha 1A subunit




chr7_+_4721722 15.534 NM_001037165
FOXK1
forkhead box K1
chrX_-_140271293 15.432 NM_012317
LDOC1
leucine zipper, down-regulated in cancer 1
chr19_+_35521591 15.428 NM_001037
NM_199037
SCN1B

sodium channel, voltage-gated, type I, beta

chr1_+_10270680 15.360 NM_015074
NM_183416
KIF1B

kinesin family member 1B

chr4_-_8873453 15.313 NM_018942
HMX1
H6 family homeobox 1
chr8_+_1711869 15.287 NM_018941
CLN8
ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)
chr4_-_5890266 15.118 NM_001313
CRMP1
collapsin response mediator protein 1
chr16_+_6069094 15.092 NM_001142333
NM_018723
RBFOX1

RNA binding protein, fox-1 homolog (C. elegans) 1

chr20_-_590909 15.079 NM_004609
TCF15
transcription factor 15 (basic helix-loop-helix)
chr12_-_106532447 15.066 NUAK1
NUAK family, SNF1-like kinase, 1
chr17_-_1531543 15.063 SLC43A2
solute carrier family 43, member 2
chr1_-_57888785 15.061 DAB1
disabled homolog 1 (Drosophila)
chr8_-_121823696 15.033 SNTB1
syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
chr19_-_9731883 14.933 NM_152289
ZNF561
zinc finger protein 561
chr16_+_2570322 14.909 NM_001145815
NM_015944
AMDHD2

amidohydrolase domain containing 2

chrX_-_8700170 14.855 NM_000216
KAL1
Kallmann syndrome 1 sequence
chr7_-_143059696 14.837 NM_001031690
FAM131B
family with sequence similarity 131, member B
chr7_+_29234325 14.766 CHN2
chimerin (chimaerin) 2
chr22_+_26565424 14.762 NM_001184773
NM_001184774
NM_001184775
NM_001184776
NM_001184777
NM_021115
SEZ6L





seizure related 6 homolog (mouse)-like





chr16_+_56225250 14.711 NM_020988
NM_138736
GNAO1

guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O

chr14_+_100150596 14.694 NM_006668
CYP46A1
cytochrome P450, family 46, subfamily A, polypeptide 1
chr18_-_78005230 14.688 NM_032510
PARD6G
par-6 partitioning defective 6 homolog gamma (C. elegans)
chr22_-_39548448 14.615 NM_175709
CBX7
chromobox homolog 7
chrX_-_47479229 14.553 NM_006950
NM_133499
SYN1

synapsin I

chr1_+_77747602 14.537 NM_174858
AK5
adenylate kinase 5
chr11_-_12030622 14.524 NM_015881
DKK3
dickkopf 3 homolog (Xenopus laevis)
chr19_-_42746678 14.524 GSK3A
glycogen synthase kinase 3 alpha
chr1_-_241520467 14.508 NM_002924
RGS7
regulator of G-protein signaling 7

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.82 1.88e-42 GO:0007399 nervous system development
1.52 1.95e-41 GO:0048856 anatomical structure development
1.54 6.02e-40 GO:0048731 system development
1.45 4.07e-39 GO:0032502 developmental process
1.46 1.12e-37 GO:0007275 multicellular organismal development
1.25 4.10e-37 GO:0065007 biological regulation
1.43 2.08e-35 GO:0023052 signaling
1.25 2.13e-33 GO:0050789 regulation of biological process
1.26 2.57e-33 GO:0050794 regulation of cellular process
1.15 1.13e-32 GO:0009987 cellular process
1.55 4.44e-28 GO:0048869 cellular developmental process
1.55 7.84e-28 GO:0030154 cell differentiation
1.66 3.36e-27 GO:0009653 anatomical structure morphogenesis
1.86 7.73e-27 GO:0022008 neurogenesis
1.87 6.78e-26 GO:0048699 generation of neurons
1.59 2.16e-24 GO:0023051 regulation of signaling
1.38 3.85e-24 GO:0007165 signal transduction
1.28 5.21e-23 GO:0032501 multicellular organismal process
1.91 4.23e-22 GO:0030182 neuron differentiation
1.64 7.60e-22 GO:0051239 regulation of multicellular organismal process
1.77 1.29e-21 GO:0048468 cell development
1.50 1.49e-20 GO:0048513 organ development
1.30 1.01e-19 GO:0051716 cellular response to stimulus
2.02 1.01e-19 GO:0007417 central nervous system development
1.72 9.42e-19 GO:0050793 regulation of developmental process
1.99 4.42e-18 GO:0000904 cell morphogenesis involved in differentiation
1.64 3.52e-17 GO:0010646 regulation of cell communication
1.89 3.76e-17 GO:0048666 neuron development
1.40 4.71e-17 GO:0048519 negative regulation of biological process
2.02 7.08e-17 GO:0048667 cell morphogenesis involved in neuron differentiation
1.42 1.17e-16 GO:0048523 negative regulation of cellular process
1.53 1.19e-16 GO:0009966 regulation of signal transduction
1.95 1.51e-16 GO:0019226 transmission of nerve impulse
1.95 1.51e-16 GO:0035637 multicellular organismal signaling
2.00 1.92e-16 GO:0048812 neuron projection morphogenesis
1.83 2.69e-16 GO:0032989 cellular component morphogenesis
2.02 5.58e-16 GO:0007409 axonogenesis
1.46 5.89e-16 GO:0007166 cell surface receptor linked signaling pathway
1.84 7.94e-16 GO:0000902 cell morphogenesis
1.92 1.23e-15 GO:0048858 cell projection morphogenesis
1.78 1.34e-15 GO:0045595 regulation of cell differentiation
1.99 1.45e-15 GO:0007268 synaptic transmission
1.92 2.61e-15 GO:0031175 neuron projection development
1.73 2.77e-15 GO:2000026 regulation of multicellular organismal development
1.90 3.41e-15 GO:0032990 cell part morphogenesis
1.79 8.78e-15 GO:0030030 cell projection organization
1.38 1.27e-14 GO:0042221 response to chemical stimulus
1.71 1.36e-14 GO:0007267 cell-cell signaling
1.42 2.86e-14 GO:0048583 regulation of response to stimulus
1.34 4.89e-14 GO:0048518 positive regulation of biological process
1.75 9.11e-14 GO:0007167 enzyme linked receptor protein signaling pathway
1.91 1.41e-13 GO:0051094 positive regulation of developmental process
2.02 1.52e-13 GO:0007420 brain development
1.58 2.31e-13 GO:0007154 cell communication
1.37 5.54e-13 GO:0065008 regulation of biological quality
1.76 5.58e-13 GO:0009887 organ morphogenesis
2.04 5.74e-13 GO:0007411 axon guidance
1.35 7.69e-13 GO:0048522 positive regulation of cellular process
1.86 8.61e-13 GO:0072358 cardiovascular system development
1.86 8.61e-13 GO:0072359 circulatory system development
1.56 5.53e-12 GO:0032879 regulation of localization
2.00 7.76e-12 GO:0044057 regulation of system process
1.78 1.86e-11 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.97 4.21e-11 GO:0045597 positive regulation of cell differentiation
1.26 1.37e-10 GO:0016043 cellular component organization
1.44 1.78e-10 GO:0035556 intracellular signal transduction
1.25 2.11e-10 GO:0031323 regulation of cellular metabolic process
1.23 2.41e-10 GO:0019222 regulation of metabolic process
1.25 2.67e-10 GO:0080090 regulation of primary metabolic process
1.17 7.44e-10 GO:0050896 response to stimulus
1.64 7.52e-10 GO:0009719 response to endogenous stimulus
1.52 9.45e-10 GO:0042127 regulation of cell proliferation
2.81 1.24e-09 GO:0001505 regulation of neurotransmitter levels
1.95 1.32e-09 GO:0022603 regulation of anatomical structure morphogenesis
1.29 1.85e-09 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.53 7.01e-09 GO:0040011 locomotion
1.24 7.85e-09 GO:0060255 regulation of macromolecule metabolic process
1.89 1.33e-08 GO:0060284 regulation of cell development
2.03 1.60e-08 GO:0007507 heart development
1.23 1.96e-08 GO:0071840 cellular component organization or biogenesis
1.94 2.04e-08 GO:0007423 sensory organ development
1.27 2.58e-08 GO:0031326 regulation of cellular biosynthetic process
1.52 2.64e-08 GO:0009888 tissue development
1.42 2.88e-08 GO:0010033 response to organic substance
1.27 3.38e-08 GO:0051171 regulation of nitrogen compound metabolic process
1.27 3.53e-08 GO:0071842 cellular component organization at cellular level
1.27 5.02e-08 GO:0009889 regulation of biosynthetic process
2.52 8.01e-08 GO:0006836 neurotransmitter transport
1.22 1.02e-07 GO:0051179 localization
2.10 1.14e-07 GO:0048732 gland development
1.91 1.19e-07 GO:0051960 regulation of nervous system development
1.60 1.23e-07 GO:0009725 response to hormone stimulus
1.55 1.45e-07 GO:0051049 regulation of transport
1.55 3.51e-07 GO:0009790 embryo development
1.57 3.65e-07 GO:0001932 regulation of protein phosphorylation
1.45 5.15e-07 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.29 5.71e-07 GO:0006355 regulation of transcription, DNA-dependent
1.49 5.83e-07 GO:0051128 regulation of cellular component organization
1.55 6.92e-07 GO:0010628 positive regulation of gene expression
1.84 1.06e-06 GO:0001944 vasculature development
1.54 1.27e-06 GO:0042325 regulation of phosphorylation
1.44 1.30e-06 GO:0009605 response to external stimulus
1.78 1.65e-06 GO:0051093 negative regulation of developmental process
1.90 1.92e-06 GO:0050767 regulation of neurogenesis
1.87 2.09e-06 GO:0045596 negative regulation of cell differentiation
1.50 2.21e-06 GO:0006468 protein phosphorylation
1.23 2.28e-06 GO:0051234 establishment of localization
1.46 2.37e-06 GO:0006351 transcription, DNA-dependent
1.24 2.74e-06 GO:0071841 cellular component organization or biogenesis at cellular level
1.52 2.80e-06 GO:0019220 regulation of phosphate metabolic process
1.52 2.80e-06 GO:0051174 regulation of phosphorus metabolic process
1.27 2.93e-06 GO:0051252 regulation of RNA metabolic process
1.65 3.10e-06 GO:0010648 negative regulation of cell communication
1.82 3.11e-06 GO:0051270 regulation of cellular component movement
1.30 3.55e-06 GO:0006464 protein modification process
1.23 3.70e-06 GO:0006810 transport
1.42 3.85e-06 GO:0006793 phosphorus metabolic process
1.42 3.85e-06 GO:0006796 phosphate metabolic process
2.57 3.88e-06 GO:0008016 regulation of heart contraction
2.06 3.99e-06 GO:0030900 forebrain development
1.74 4.28e-06 GO:0007389 pattern specification process
2.17 5.05e-06 GO:0050678 regulation of epithelial cell proliferation
1.25 5.07e-06 GO:0010468 regulation of gene expression
1.60 5.18e-06 GO:0006935 chemotaxis
1.60 5.18e-06 GO:0042330 taxis
2.30 5.23e-06 GO:0050804 regulation of synaptic transmission
1.65 5.24e-06 GO:0023057 negative regulation of signaling
2.78 5.29e-06 GO:0007269 neurotransmitter secretion
2.02 5.38e-06 GO:0014070 response to organic cyclic compound
1.54 5.45e-06 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.77 7.28e-06 GO:0007610 behavior
1.62 7.48e-06 GO:0048646 anatomical structure formation involved in morphogenesis
1.25 7.56e-06 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.53 8.29e-06 GO:0051172 negative regulation of nitrogen compound metabolic process
1.73 8.99e-06 GO:0043434 response to peptide hormone stimulus
1.51 9.49e-06 GO:0031327 negative regulation of cellular biosynthetic process
2.14 9.80e-06 GO:0031644 regulation of neurological system process
2.20 1.14e-05 GO:0051969 regulation of transmission of nerve impulse
1.64 1.46e-05 GO:0060341 regulation of cellular localization
2.61 1.65e-05 GO:0010721 negative regulation of cell development
1.24 1.69e-05 GO:0010556 regulation of macromolecule biosynthetic process
1.49 1.77e-05 GO:0009890 negative regulation of biosynthetic process
2.28 2.14e-05 GO:0003001 generation of a signal involved in cell-cell signaling
2.28 2.14e-05 GO:0023061 signal release
1.56 2.42e-05 GO:0045892 negative regulation of transcription, DNA-dependent
1.73 3.05e-05 GO:0001501 skeletal system development
2.02 3.08e-05 GO:0001654 eye development
1.42 3.09e-05 GO:0006811 ion transport
1.55 3.17e-05 GO:0051253 negative regulation of RNA metabolic process
1.81 3.25e-05 GO:0030334 regulation of cell migration
1.40 3.69e-05 GO:0009892 negative regulation of metabolic process
1.32 3.70e-05 GO:0065009 regulation of molecular function
1.61 4.04e-05 GO:0006873 cellular ion homeostasis
1.74 4.77e-05 GO:0048729 tissue morphogenesis
1.62 4.78e-05 GO:0008285 negative regulation of cell proliferation
1.66 5.42e-05 GO:0048598 embryonic morphogenesis
2.15 5.58e-05 GO:0010769 regulation of cell morphogenesis involved in differentiation
1.83 5.64e-05 GO:0003002 regionalization
1.51 6.00e-05 GO:0010629 negative regulation of gene expression
1.78 6.27e-05 GO:2000145 regulation of cell motility
1.78 6.56e-05 GO:0001568 blood vessel development
1.60 6.62e-05 GO:0032583 regulation of gene-specific transcription
1.64 6.64e-05 GO:0007264 small GTPase mediated signal transduction
1.62 6.70e-05 GO:0009968 negative regulation of signal transduction
2.12 6.80e-05 GO:0030111 regulation of Wnt receptor signaling pathway
1.55 7.43e-05 GO:0008284 positive regulation of cell proliferation
1.27 7.64e-05 GO:0043412 macromolecule modification
2.13 7.73e-05 GO:0022604 regulation of cell morphogenesis
1.41 8.47e-05 GO:0031324 negative regulation of cellular metabolic process
1.57 8.62e-05 GO:0050801 ion homeostasis
2.21 1.01e-04 GO:0007611 learning or memory
1.58 1.06e-04 GO:0055082 cellular chemical homeostasis
1.83 1.17e-04 GO:0002009 morphogenesis of an epithelium
1.33 1.19e-04 GO:0009893 positive regulation of metabolic process
1.90 1.22e-04 GO:0043408 regulation of MAPKKK cascade
1.71 1.25e-04 GO:0051130 positive regulation of cellular component organization
1.43 1.54e-04 GO:0051173 positive regulation of nitrogen compound metabolic process
1.73 2.34e-04 GO:0061061 muscle structure development
1.62 2.57e-04 GO:0090066 regulation of anatomical structure size
1.46 2.66e-04 GO:0010558 negative regulation of macromolecule biosynthetic process
1.42 2.85e-04 GO:0031399 regulation of protein modification process
1.53 3.06e-04 GO:0009967 positive regulation of signal transduction
2.07 3.11e-04 GO:0043010 camera-type eye development
1.79 3.38e-04 GO:0032868 response to insulin stimulus
1.99 3.61e-04 GO:0045165 cell fate commitment
1.51 3.65e-04 GO:0010647 positive regulation of cell communication
2.19 4.03e-04 GO:0010720 positive regulation of cell development
1.47 4.21e-04 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.34 4.38e-04 GO:0010604 positive regulation of macromolecule metabolic process
1.42 4.40e-04 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.84 4.41e-04 GO:0045664 regulation of neuron differentiation
1.54 4.63e-04 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.94 5.11e-04 GO:0009952 anterior/posterior pattern formation
1.50 5.51e-04 GO:0023056 positive regulation of signaling
1.98 5.54e-04 GO:0001655 urogenital system development
1.46 5.57e-04 GO:0045893 positive regulation of transcription, DNA-dependent
1.66 5.76e-04 GO:0051046 regulation of secretion
1.53 5.84e-04 GO:0030001 metal ion transport
1.39 5.88e-04 GO:0016310 phosphorylation
1.60 5.89e-04 GO:0060429 epithelium development
1.60 5.92e-04 GO:0051056 regulation of small GTPase mediated signal transduction
1.51 6.18e-04 GO:0051338 regulation of transferase activity
1.69 6.30e-04 GO:0040012 regulation of locomotion
2.18 6.39e-04 GO:0021700 developmental maturation
1.46 6.51e-04 GO:0048878 chemical homeostasis
1.52 6.72e-04 GO:0043549 regulation of kinase activity
1.61 7.02e-04 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
1.51 7.41e-04 GO:0048585 negative regulation of response to stimulus
2.57 7.93e-04 GO:0050768 negative regulation of neurogenesis
1.82 8.26e-04 GO:0044087 regulation of cellular component biogenesis
1.37 8.65e-04 GO:0010605 negative regulation of macromolecule metabolic process
2.07 8.70e-04 GO:0050890 cognition
1.63 9.83e-04 GO:0032535 regulation of cellular component size
1.69 1.05e-03 GO:0035295 tube development
1.36 1.06e-03 GO:0032774 RNA biosynthetic process
2.27 1.11e-03 GO:0060828 regulation of canonical Wnt receptor signaling pathway
1.55 1.19e-03 GO:0040008 regulation of growth
1.57 1.27e-03 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.43 1.28e-03 GO:0051254 positive regulation of RNA metabolic process
1.58 1.33e-03 GO:0009792 embryo development ending in birth or egg hatching
1.59 1.34e-03 GO:0043009 chordate embryonic development
1.71 1.38e-03 GO:0008361 regulation of cell size
2.36 1.58e-03 GO:0022612 gland morphogenesis
1.62 1.63e-03 GO:0015672 monovalent inorganic cation transport
1.53 1.73e-03 GO:0046903 secretion
1.51 1.76e-03 GO:0045859 regulation of protein kinase activity
1.76 1.85e-03 GO:0048514 blood vessel morphogenesis
1.31 1.88e-03 GO:0031325 positive regulation of cellular metabolic process
2.62 2.09e-03 GO:0090090 negative regulation of canonical Wnt receptor signaling pathway
1.46 2.44e-03 GO:0006812 cation transport
2.35 2.55e-03 GO:0048638 regulation of developmental growth
1.11 2.60e-03 GO:0044237 cellular metabolic process
1.65 2.66e-03 GO:0042493 response to drug
1.97 3.17e-03 GO:0048705 skeletal system morphogenesis
1.78 3.48e-03 GO:0003013 circulatory system process
1.78 3.48e-03 GO:0008015 blood circulation
1.98 3.69e-03 GO:0001763 morphogenesis of a branching structure
1.91 3.72e-03 GO:0046883 regulation of hormone secretion
2.05 3.78e-03 GO:0050796 regulation of insulin secretion
2.10 4.23e-03 GO:0043410 positive regulation of MAPKKK cascade
1.99 4.30e-03 GO:0010959 regulation of metal ion transport
1.61 4.46e-03 GO:0032940 secretion by cell
2.24 4.52e-03 GO:0030178 negative regulation of Wnt receptor signaling pathway
1.86 4.79e-03 GO:0006813 potassium ion transport
2.00 5.01e-03 GO:0002791 regulation of peptide secretion
2.00 5.01e-03 GO:0090087 regulation of peptide transport
1.59 5.14e-03 GO:0071495 cellular response to endogenous stimulus
2.76 5.14e-03 GO:0007613 memory
1.37 5.19e-03 GO:0048584 positive regulation of response to stimulus
2.52 5.45e-03 GO:0048593 camera-type eye morphogenesis
2.04 5.87e-03 GO:0072001 renal system development
1.92 6.02e-03 GO:0008286 insulin receptor signaling pathway
2.31 6.08e-03 GO:0050770 regulation of axonogenesis
1.88 6.14e-03 GO:0034762 regulation of transmembrane transport
2.21 6.46e-03 GO:0048592 eye morphogenesis
1.68 6.78e-03 GO:0040007 growth
1.99 7.71e-03 GO:0007265 Ras protein signal transduction
1.99 7.71e-03 GO:0090276 regulation of peptide hormone secretion
1.99 8.98e-03 GO:0060541 respiratory system development
2.19 9.14e-03 GO:0060485 mesenchyme development
1.70 9.18e-03 GO:0071375 cellular response to peptide hormone stimulus
1.82 9.65e-03 GO:0070482 response to oxygen levels
2.08 1.04e-02 GO:0030278 regulation of ossification
2.01 1.21e-02 GO:0048736 appendage development
2.01 1.21e-02 GO:0060173 limb development
1.84 1.26e-02 GO:0001666 response to hypoxia
2.43 1.32e-02 GO:0007612 learning
2.02 1.41e-02 GO:0001822 kidney development
3.43 1.45e-02 GO:0002027 regulation of heart rate
1.67 1.63e-02 GO:0048568 embryonic organ development
2.19 1.63e-02 GO:0050679 positive regulation of epithelial cell proliferation
2.00 1.87e-02 GO:0061138 morphogenesis of a branching epithelium
1.51 1.92e-02 GO:0010627 regulation of intracellular protein kinase cascade
1.36 1.95e-02 GO:0010557 positive regulation of macromolecule biosynthetic process
2.39 2.02e-02 GO:0034765 regulation of ion transmembrane transport
1.43 2.06e-02 GO:0019725 cellular homeostasis
3.52 2.13e-02 GO:0046928 regulation of neurotransmitter secretion
2.79 2.20e-02 GO:0001952 regulation of cell-matrix adhesion
1.82 2.37e-02 GO:0031344 regulation of cell projection organization
2.06 2.53e-02 GO:0021537 telencephalon development
2.12 2.81e-02 GO:0055123 digestive system development
3.63 3.06e-02 GO:0007398 ectoderm development
1.79 3.13e-02 GO:0048562 embryonic organ morphogenesis
1.48 3.29e-02 GO:0007243 intracellular protein kinase cascade
1.48 3.29e-02 GO:0023014 signal transduction via phosphorylation event
1.91 3.40e-02 GO:0033273 response to vitamin
1.86 3.41e-02 GO:0042391 regulation of membrane potential
1.71 3.42e-02 GO:0006874 cellular calcium ion homeostasis
2.42 3.49e-02 GO:0032412 regulation of ion transmembrane transporter activity
2.81 3.58e-02 GO:0042733 embryonic digit morphogenesis
2.10 3.86e-02 GO:0007160 cell-matrix adhesion
2.00 3.92e-02 GO:0003007 heart morphogenesis
2.17 4.12e-02 GO:2000027 regulation of organ morphogenesis
3.77 4.25e-02 GO:0048048 embryonic eye morphogenesis
3.09 4.31e-02 GO:0051588 regulation of neurotransmitter transport
2.11 4.42e-02 GO:0050769 positive regulation of neurogenesis
5.14 4.74e-02 GO:0060687 regulation of branching involved in prostate gland morphogenesis

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.45 4.33e-21 GO:0044459 plasma membrane part
1.43 2.06e-10 GO:0031226 intrinsic to plasma membrane
1.43 3.27e-10 GO:0005887 integral to plasma membrane
1.08 1.85e-08 GO:0044424 intracellular part
1.08 3.33e-08 GO:0005622 intracellular
1.71 4.31e-08 GO:0045202 synapse
1.47 8.59e-08 GO:0042995 cell projection
1.47 1.07e-07 GO:0005626 insoluble fraction
1.69 1.55e-07 GO:0043005 neuron projection
1.40 2.15e-07 GO:0000267 cell fraction
1.47 3.31e-07 GO:0005624 membrane fraction
1.18 7.99e-07 GO:0005886 plasma membrane
1.18 9.30e-07 GO:0071944 cell periphery
1.43 6.42e-06 GO:0031982 vesicle
1.04 1.04e-05 GO:0044464 cell part
1.04 1.11e-05 GO:0005623 cell
1.44 1.31e-05 GO:0031988 membrane-bounded vesicle
2.02 4.80e-05 GO:0034703 cation channel complex
1.66 8.85e-05 GO:0044456 synapse part
1.41 9.36e-05 GO:0016023 cytoplasmic membrane-bounded vesicle
1.39 1.44e-04 GO:0031410 cytoplasmic vesicle
1.55 3.63e-04 GO:0031012 extracellular matrix
1.81 3.92e-04 GO:0030424 axon
1.09 4.34e-04 GO:0005737 cytoplasm
2.09 4.84e-04 GO:0019898 extrinsic to membrane
1.73 5.50e-04 GO:0034702 ion channel complex
1.42 6.13e-04 GO:0030054 cell junction
2.18 6.69e-04 GO:0030665 clathrin coated vesicle membrane
1.82 9.05e-04 GO:0030136 clathrin-coated vesicle
2.13 1.30e-03 GO:0008021 synaptic vesicle
2.70 1.88e-03 GO:0043679 axon terminus
2.57 5.13e-03 GO:0044306 neuron projection terminus
2.84 1.24e-02 GO:0034704 calcium channel complex
1.44 1.72e-02 GO:0044463 cell projection part
1.06 2.26e-02 GO:0043226 organelle
1.62 2.36e-02 GO:0030135 coated vesicle
2.03 2.61e-02 GO:0033267 axon part
1.95 2.88e-02 GO:0008076 voltage-gated potassium channel complex
1.95 2.88e-02 GO:0034705 potassium channel complex
1.87 3.80e-02 GO:0019717 synaptosome
1.79 4.87e-02 GO:0030662 coated vesicle membrane
1.06 4.96e-02 GO:0043229 intracellular organelle

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.11 5.25e-23 GO:0005488 binding
1.20 3.30e-22 GO:0005515 protein binding
1.51 7.75e-11 GO:0001071 nucleic acid binding transcription factor activity
1.51 7.75e-11 GO:0003700 sequence-specific DNA binding transcription factor activity
1.58 2.65e-09 GO:0043565 sequence-specific DNA binding
1.43 1.93e-07 GO:0030528 transcription regulator activity
1.83 5.94e-07 GO:0005261 cation channel activity
1.49 8.41e-07 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.46 1.50e-06 GO:0016301 kinase activity
2.54 1.58e-06 GO:0019199 transmembrane receptor protein kinase activity
1.52 2.20e-06 GO:0004672 protein kinase activity
1.54 4.29e-06 GO:0008324 cation transmembrane transporter activity
1.73 5.51e-06 GO:0022836 gated channel activity
2.31 6.53e-06 GO:0005057 receptor signaling protein activity
1.40 1.23e-05 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.56 2.01e-05 GO:0060589 nucleoside-triphosphatase regulator activity
1.90 2.24e-05 GO:0005244 voltage-gated ion channel activity
1.90 2.24e-05 GO:0022832 voltage-gated channel activity
1.44 2.67e-05 GO:0015075 ion transmembrane transporter activity
2.03 3.36e-05 GO:0022843 voltage-gated cation channel activity
1.55 3.87e-05 GO:0030695 GTPase regulator activity
1.58 4.43e-05 GO:0022803 passive transmembrane transporter activity
1.57 7.14e-05 GO:0015267 channel activity
1.32 8.85e-05 GO:0005215 transporter activity
2.53 1.22e-04 GO:0004714 transmembrane receptor protein tyrosine kinase activity
1.57 1.38e-04 GO:0022838 substrate-specific channel activity
1.35 1.57e-04 GO:0022892 substrate-specific transporter activity
1.36 1.71e-04 GO:0022857 transmembrane transporter activity
1.69 1.86e-04 GO:0032403 protein complex binding
1.37 1.91e-04 GO:0022891 substrate-specific transmembrane transporter activity
1.57 1.92e-04 GO:0005216 ion channel activity
1.24 2.03e-04 GO:0032553 ribonucleotide binding
1.24 2.03e-04 GO:0032555 purine ribonucleotide binding
1.21 2.83e-04 GO:0003677 DNA binding
1.24 2.92e-04 GO:0017076 purine nucleotide binding
1.93 8.60e-04 GO:0004713 protein tyrosine kinase activity
1.23 1.22e-03 GO:0035639 purine ribonucleoside triphosphate binding
1.50 1.27e-03 GO:0004674 protein serine/threonine kinase activity
1.60 1.86e-03 GO:0008134 transcription factor binding
1.20 2.13e-03 GO:0000166 nucleotide binding
2.63 2.29e-03 GO:0046332 SMAD binding
2.20 2.61e-03 GO:0005262 calcium channel activity
3.16 3.43e-03 GO:0005245 voltage-gated calcium channel activity
1.36 3.47e-03 GO:0019899 enzyme binding
1.56 4.70e-03 GO:0016564 transcription repressor activity
1.64 5.09e-03 GO:0019900 kinase binding
1.88 6.81e-03 GO:0005267 potassium channel activity
1.23 6.91e-03 GO:0032559 adenyl ribonucleotide binding
1.54 8.38e-03 GO:0016563 transcription activator activity
1.23 8.58e-03 GO:0030554 adenyl nucleotide binding
1.81 1.06e-02 GO:0005516 calmodulin binding
1.45 1.06e-02 GO:0019904 protein domain specific binding
1.30 1.20e-02 GO:0030234 enzyme regulator activity
1.65 1.38e-02 GO:0000975 regulatory region DNA binding
1.65 1.38e-02 GO:0001067 regulatory region nucleic acid binding
1.65 1.38e-02 GO:0044212 transcription regulatory region DNA binding
1.13 2.00e-02 GO:0046872 metal ion binding
1.64 2.73e-02 GO:0010843 promoter binding
1.32 2.80e-02 GO:0042802 identical protein binding
1.71 2.87e-02 GO:0005085 guanyl-nucleotide exchange factor activity
1.38 3.18e-02 GO:0008092 cytoskeletal protein binding
1.55 4.12e-02 GO:0005096 GTPase activator activity
1.44 4.15e-02 GO:0008047 enzyme activator activity
1.20 4.16e-02 GO:0016740 transferase activity
1.21 4.34e-02 GO:0005524 ATP binding
1.12 4.68e-02 GO:0043169 cation binding