Motif ID: MYBL2.p2

Z-value: 0.997


Transcription factors associated with MYBL2.p2:

Gene SymbolEntrez IDGene Name
MYBL2 4605 v-myb myeloblastosis viral oncogene homolog (avian)-like 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
MYBL2chr20_+_42295747-0.228.3e-04Click!


Activity profile for motif MYBL2.p2.

activity profile for motif MYBL2.p2


Sorted Z-values histogram for motif MYBL2.p2

Sorted Z-values for motif MYBL2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of MYBL2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_-_71791734 22.312 NUMA1
nuclear mitotic apparatus protein 1
chr10_+_17270257 21.643 NM_003380
VIM
vimentin
chr11_-_124543598 21.072 NM_170601
SIAE
sialic acid acetylesterase
chr2_+_143886969 19.070 ARHGAP15
Rho GTPase activating protein 15
chr11_-_64512925 16.939 NM_153819
RASGRP2
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
chr2_+_143886898 16.913 NM_018460
ARHGAP15
Rho GTPase activating protein 15
chr1_+_198608244 16.553 PTPRC
protein tyrosine phosphatase, receptor type, C
chr10_+_17270469 15.761 VIM
vimentin
chr11_+_71791376 15.266 NM_001145307
NM_001145308
NM_001205138
NM_145309
LRTOMT



leucine rich transmembrane and 0-methyltransferase domain containing



chr11_+_92085261 12.076 NM_001008781
FAT3
FAT tumor suppressor homolog 3 (Drosophila)
chr10_-_28571014 9.771 NM_173496
MPP7
membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)
chr3_+_122044010 9.343 NM_005213
CSTA
cystatin A (stefin A)
chr1_-_150780705 9.247 NM_000396
CTSK
cathepsin K
chr7_+_80267972 8.619 CD36
CD36 molecule (thrombospondin receptor)
chr14_-_21944826 7.902 NM_001163380
RAB2B
RAB2B, member RAS oncogene family
chr1_+_144614958 6.876 NM_001037675
NBPF9
NBPF8
neuroblastoma breakpoint family, member 9
neuroblastoma breakpoint family, member 8
chr1_+_198608216 6.657 PTPRC
protein tyrosine phosphatase, receptor type, C
chr1_+_198608136 6.520 NM_002838
NM_080921
NM_080923
PTPRC


protein tyrosine phosphatase, receptor type, C


chr1_-_203320249 6.374


chr6_-_32908583 6.055 NM_002118
HLA-DMB
major histocompatibility complex, class II, DM beta
chr1_+_174844655 5.876 NM_001035230
RABGAP1L
RAB GTPase activating protein 1-like
chr2_+_68961912 5.746 NM_001007231
NM_001166277
ARHGAP25

Rho GTPase activating protein 25

chr11_+_128563973 5.724 FLI1
Friend leukemia virus integration 1
chr7_+_80267922 5.707 CD36
CD36 molecule (thrombospondin receptor)
chr17_+_47865980 5.465 NM_001199155
NM_001199156
NM_001199157
NM_001199158
NM_007067
KAT7




K(lysine) acetyltransferase 7




chr17_+_47866061 5.345 KAT7
K(lysine) acetyltransferase 7
chr3_+_157154579 5.293 NM_002852
PTX3
pentraxin 3, long
chr11_+_128563993 5.271 FLI1
Friend leukemia virus integration 1
chr6_+_35265654 5.259 DEF6
differentially expressed in FDCP 6 homolog (mouse)
chr1_-_203320185 5.218 FMOD
fibromodulin
chr5_+_73109342 5.156 NM_001244364
RGNEF
190 kDa guanine nucleotide exchange factor
chr12_-_15114495 5.141 NM_001175
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr6_-_24877453 5.031 NM_015864
FAM65B
family with sequence similarity 65, member B
chr1_+_92414927 4.989 NM_001242805
NM_001242806
NM_001242807
NM_001242808
NM_001242810
NM_207189
BRDT





bromodomain, testis-specific





chr16_-_71610948 4.973 NM_000353
TAT
tyrosine aminotransferase
chr19_+_41509825 4.966 CYP2B6
cytochrome P450, family 2, subfamily B, polypeptide 6
chr11_+_128563772 4.895 NM_001167681
NM_002017
FLI1

Friend leukemia virus integration 1

chr9_-_95298251 4.828 NM_001197295
NM_001197296
NM_001393
ECM2


extracellular matrix protein 2, female organ and adipocyte specific


chr13_-_48987247 4.767 LPAR6
lysophosphatidic acid receptor 6
chr17_+_47866119 4.728 KAT7
K(lysine) acetyltransferase 7
chr19_+_19144520 4.637 ARMC6
armadillo repeat containing 6
chr19_+_19144617 4.627 ARMC6
armadillo repeat containing 6
chr5_+_55062712 4.562 NM_001166534
DDX4
DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
chr7_+_139528951 4.511 NM_001061
NM_001166253
NM_030984
TBXAS1


thromboxane A synthase 1 (platelet)


chr7_+_80267782 4.486 NM_000072
NM_001001548
CD36

CD36 molecule (thrombospondin receptor)

chr3_-_114478117 4.461 NM_001164344
NM_001164345
ZBTB20

zinc finger and BTB domain containing 20

chr2_-_178129294 4.238 NFE2L2
nuclear factor (erythroid-derived 2)-like 2
chr7_-_99149533 4.200 NM_145111
FAM200A
family with sequence similarity 200, member A
chr5_-_39425297 4.189 NM_001244871
NM_001343
DAB2

disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)

chr1_-_93399531 4.181


chr3_-_50608421 4.062 NM_001171741
C3orf18
chromosome 3 open reading frame 18
chr12_-_9913415 3.961 NM_001781
CD69
CD69 molecule
chr17_-_48264039 3.853 COL1A1
collagen, type I, alpha 1
chr1_-_92952429 3.850 NM_005263
GFI1
growth factor independent 1 transcription repressor
chr3_-_123339178 3.812 MYLK
myosin light chain kinase
chr1_-_203320287 3.811 NM_002023
FMOD
fibromodulin
chr8_+_110099652 3.792 NM_003301
TRHR
thyrotropin-releasing hormone receptor
chr19_-_39826676 3.772 NM_004877
GMFG
glia maturation factor, gamma
chr11_+_128564130 3.740 FLI1
Friend leukemia virus integration 1
chrX_+_135730335 3.724 NM_000074
CD40LG
CD40 ligand
chr13_-_48987017 3.709 LPAR6
lysophosphatidic acid receptor 6
chr1_+_148577356 3.468 NM_001102663
NBPF15
NBPF16
neuroblastoma breakpoint family, member 15
neuroblastoma breakpoint family, member 16
chr6_+_100054649 3.458 NM_021620
PRDM13
PR domain containing 13
chr19_-_39826625 3.436 GMFG
glia maturation factor, gamma
chr3_-_129118241 3.428 RPL32P3
ribosomal protein L32 pseudogene 3
chr9_+_4792974 3.350 RCL1
RNA terminal phosphate cyclase-like 1
chr1_+_247579457 3.286 NM_001079821
NM_001127461
NLRP3

NLR family, pyrin domain containing 3

chr2_-_40657419 3.261 NM_001112800
NM_001112801
NM_001252624
NM_021097
SLC8A1



solute carrier family 8 (sodium/calcium exchanger), member 1



chr1_+_113498984 3.236 LOC100506392
uncharacterized LOC100506392
chrX_-_32430370 3.232 NM_004011
NM_004012
DMD

dystrophin

chr1_-_173793454 3.224 CENPL
centromere protein L
chr5_-_39424930 3.183 DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr1_-_173793268 3.174 NM_001171182
CENPL
centromere protein L
chr17_+_48821106 3.135 LUC7L3
LUC7-like 3 (S. cerevisiae)
chrX_-_15332680 3.127 NM_001012428
ASB11
ankyrin repeat and SOCS box containing 11
chr5_-_39425030 3.116 DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr22_-_38881529 3.106 DDX17
DEAD (Asp-Glu-Ala-Asp) box polypeptide 17
chr6_+_153019029 3.090 NM_025107
MYCT1
myc target 1
chr9_+_36169384 3.087 NM_005893
CCIN
calicin
chr17_+_26800657 3.080 NM_001145975
NM_001145976
NM_003984
SLC13A2


solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2


chr22_+_40322609 3.011 GRAP2
GRB2-related adaptor protein 2
chr16_+_4838397 2.980 NM_001253790
NM_001253791
LOC440335

uncharacterized LOC440335

chrX_+_135278912 2.962 NM_001159701
NM_001159699
FHL1

four and a half LIM domains 1

chr3_-_187452669 2.954 NM_001134738
BCL6
B-cell CLL/lymphoma 6
chr13_-_48987652 2.942 NM_001162498
LPAR6
lysophosphatidic acid receptor 6
chr14_+_21423627 2.927 NM_002934
RNASE2
ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
chr10_+_35464514 2.893 NM_182769
NM_182770
CREM

cAMP responsive element modulator

chr12_-_91576805 2.864 NM_001920
DCN
decorin
chr5_-_157002705 2.828


chr8_-_67579478 2.826 VCPIP1
valosin containing protein (p97)/p47 complex interacting protein 1
chr10_-_99052358 2.795 ARHGAP19
Rho GTPase activating protein 19
chr1_-_9129620 2.771 SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr15_+_43809805 2.705 NM_002373
MAP1A
microtubule-associated protein 1A
chr3_-_49851356 2.700 NM_003335
UBA7
ubiquitin-like modifier activating enzyme 7
chr19_-_19144262 2.673 SUGP2
SURP and G patch domain containing 2
chr11_-_84634219 2.671 DLG2
discs, large homolog 2 (Drosophila)
chr22_-_38380538 2.653 NM_006941
SOX10
SRY (sex determining region Y)-box 10
chr11_+_124543739 2.652 NM_017425
SPA17
sperm autoantigenic protein 17
chr4_-_88450601 2.651 NM_001128310
NM_004684
SPARCL1

SPARC-like 1 (hevin)

chr19_-_19144304 2.625 SUGP2
SURP and G patch domain containing 2
chr17_+_28268622 2.599 NM_198529
EFCAB5
EF-hand calcium binding domain 5
chr6_-_108145507 2.598 NM_198081
SCML4
sex comb on midleg-like 4 (Drosophila)
chr17_-_70588942 2.559 LOC100499467
uncharacterized LOC100499467
chr2_+_170366211 2.549 NM_006063
KBTBD10
kelch repeat and BTB (POZ) domain containing 10
chr2_+_169929009 2.536 NM_001142270
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr3_+_16974581 2.465 NM_015184
PLCL2
phospholipase C-like 2
chr11_-_62457370 2.464 NM_203422
LRRN4CL
LRRN4 C-terminal like
chr3_-_50378238 2.445 NM_001206957
NM_007182
NM_170714
RASSF1


Ras association (RalGDS/AF-6) domain family member 1


chr2_-_152590983 2.430 NM_001164507
NM_001164508
NM_004543
NEB


nebulin


chr7_+_20686965 2.424 NM_001163942
NM_001163993
NM_178559
ABCB5


ATP-binding cassette, sub-family B (MDR/TAP), member 5


chr3_-_123339423 2.424 NM_053031
NM_053032
MYLK

myosin light chain kinase

chr17_-_34417386 2.419 NM_002983
CCL3
chemokine (C-C motif) ligand 3
chr6_-_55740358 2.413 NM_021073
BMP5
bone morphogenetic protein 5
chr14_-_23288912 2.403 NM_001126106
SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr4_-_48014960 2.401 NM_000087
CNGA1
cyclic nucleotide gated channel alpha 1
chr3_-_56698073 2.396 NM_015224
FAM208A
family with sequence similarity 208, member A
chr11_+_128563955 2.394 FLI1
Friend leukemia virus integration 1
chr6_-_32977312 2.380 HLA-DOA
major histocompatibility complex, class II, DO alpha
chrX_-_19988381 2.370 NM_198279
CXorf23
chromosome X open reading frame 23
chrX_+_37639246 2.353 NM_000397
CYBB
cytochrome b-245, beta polypeptide
chr13_+_31309644 2.353 NM_001629
ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr1_+_150898814 2.349 NM_001145415
NM_001243491
NM_012432
SETDB1


SET domain, bifurcated 1


chr2_+_231280870 2.325 NM_001080391
NM_001206701
NM_001206702
NM_001206703
NM_003113
SP100




SP100 nuclear antigen




chrX_-_106960268 2.317 NM_004089
TSC22D3
TSC22 domain family, member 3
chr18_+_61575203 2.293 SERPINB10
serpin peptidase inhibitor, clade B (ovalbumin), member 10
chr11_-_8954534 2.274 NM_020643
C11orf16
chromosome 11 open reading frame 16
chr6_-_55740387 2.262 BMP5
bone morphogenetic protein 5
chr6_-_33239439 2.260 VPS52
vacuolar protein sorting 52 homolog (S. cerevisiae)
chr9_+_131709970 2.250 NM_015354
NUP188
nucleoporin 188kDa
chr12_+_14538232 2.248 ATF7IP
activating transcription factor 7 interacting protein
chr19_-_41870001 2.231 NM_030578
B9D2
B9 protein domain 2
chr5_+_155754172 2.225 SGCD
sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
chr3_+_121774208 2.214 NM_001206924
NM_001206925
NM_175862
CD86


CD86 molecule


chr2_+_152214105 2.206 NM_007115
TNFAIP6
tumor necrosis factor, alpha-induced protein 6
chr2_+_226265601 2.129 NM_020864
NYAP2
neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2
chr15_-_58306185 2.128 NM_170697
ALDH1A2
aldehyde dehydrogenase 1 family, member A2
chr9_+_120466453 2.120 NM_138554
TLR4
toll-like receptor 4
chr12_-_57505121 2.112 STAT6
signal transducer and activator of transcription 6, interleukin-4 induced
chr22_-_38379868 2.109 SOX10
SRY (sex determining region Y)-box 10
chr9_+_131709991 2.108 NUP188
nucleoporin 188kDa
chr4_-_166033924 2.104 TMEM192
transmembrane protein 192
chr16_-_31470582 2.098


chr9_-_73029539 2.094 NM_001206
KLF9
Kruppel-like factor 9
chrX_+_37639306 2.007 CYBB
cytochrome b-245, beta polypeptide
chr13_+_31309690 2.004 ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr2_+_27274520 2.003 AGBL5
ATP/GTP binding protein-like 5
chr12_-_4754275 2.002 NM_006422
AKAP3
A kinase (PRKA) anchor protein 3
chr1_-_9129666 1.996 NM_001135585
NM_003039
SLC2A5

solute carrier family 2 (facilitated glucose/fructose transporter), member 5

chr1_+_26485510 1.973 NM_024869
FAM110D
family with sequence similarity 110, member D
chr9_+_116356407 1.971 RGS3
regulator of G-protein signaling 3
chr6_-_112080284 1.967 NM_153048
FYN
FYN oncogene related to SRC, FGR, YES
chr7_-_99145988 1.947 FAM200A
family with sequence similarity 200, member A
chr10_-_99052391 1.942 ARHGAP19-SLIT1
ARHGAP19
ARHGAP19-SLIT1 readthrough
Rho GTPase activating protein 19
chr4_+_88720701 1.938 NM_004967
IBSP
integrin-binding sialoprotein
chr19_+_19144370 1.938 NM_001199196
NM_033415
ARMC6

armadillo repeat containing 6

chr3_+_69985750 1.929 NM_000248
NM_001184968
NM_198158
NM_198178
MITF



microphthalmia-associated transcription factor



chr1_-_173793776 1.897 NM_001127181
NM_033319
CENPL

centromere protein L

chr6_-_99849266 1.895 PNISR
PNN-interacting serine/arginine-rich protein
chr20_-_49253425 1.890 NM_080829
FAM65C
family with sequence similarity 65, member C
chr3_-_47933997 1.834 MAP4
microtubule-associated protein 4
chr19_+_9296269 1.824 NM_175883
OR7D2
olfactory receptor, family 7, subfamily D, member 2
chr2_+_231281470 1.801 NM_001206704
SP100
SP100 nuclear antigen
chr1_+_22778347 1.786 ZBTB40
zinc finger and BTB domain containing 40
chr3_+_8775485 1.781 NM_001234
NM_033337
CAV3

caveolin 3

chr21_+_43823970 1.778 NM_001001895
NM_001243467
NM_018961
UBASH3A


ubiquitin associated and SH3 domain containing A


chrX_+_118108575 1.769 LONRF3
LON peptidase N-terminal domain and ring finger 3
chr11_-_59383179 1.767 OSBP
oxysterol binding protein
chr9_+_120466625 1.763 TLR4
toll-like receptor 4
chr12_-_57504935 1.733 STAT6
signal transducer and activator of transcription 6, interleukin-4 induced
chr11_-_124805896 1.721 HEPACAM
hepatic and glial cell adhesion molecule
chr10_-_70092648 1.721 NM_001033083
NM_022129
PBLD

phenazine biosynthesis-like protein domain containing

chr19_+_48828627 1.713 NM_001425
EMP3
epithelial membrane protein 3
chr2_-_190627923 1.695 NM_022353
OSGEPL1
O-sialoglycoprotein endopeptidase-like 1
chr2_+_231280906 1.692 SP100
SP100 nuclear antigen
chr2_+_102508377 1.690 MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr9_+_116356199 1.687 NM_144489
RGS3
regulator of G-protein signaling 3
chr6_-_90024936 1.680 NM_002043
GABRR2
gamma-aminobutyric acid (GABA) receptor, rho 2
chr19_+_10531128 1.668 NM_001111307
PDE4A
phosphodiesterase 4A, cAMP-specific
chr1_+_66458389 1.663 NM_001037340
PDE4B
phosphodiesterase 4B, cAMP-specific
chr3_+_32726659 1.641 NM_015442
CNOT10
CCR4-NOT transcription complex, subunit 10
chr7_+_80231503 1.638 NM_001001547
CD36
CD36 molecule (thrombospondin receptor)
chr20_+_42187705 1.623 SGK2
serum/glucocorticoid regulated kinase 2
chr16_-_87970107 1.619 NM_001739
CA5A
carbonic anhydrase VA, mitochondrial
chr21_+_19617145 1.612 NM_024944
CHODL
chondrolectin
chr13_+_102104941 1.610 NM_004791
ITGBL1
integrin, beta-like 1 (with EGF-like repeat domains)
chr11_+_59824129 1.609 MS4A3
membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
chr1_+_207226594 1.605 NM_001018053
NM_006212
PFKFB2

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2

chr1_-_197036350 1.597 NM_001994
F13B
coagulation factor XIII, B polypeptide
chr4_+_100495972 1.594 MTTP
microsomal triglyceride transfer protein
chr21_+_40823779 1.591 NM_007341
SH3BGR
SH3 domain binding glutamic acid-rich protein
chr2_+_231280933 1.591 SP100
SP100 nuclear antigen
chr17_+_3118911 1.584 NM_014565
OR1A1
olfactory receptor, family 1, subfamily A, member 1
chr10_+_99332197 1.580 NM_001129981
NM_020349
ANKRD2

ankyrin repeat domain 2 (stretch responsive muscle)

chr10_-_99052429 1.565 NM_001204300
NM_032900
ARHGAP19

Rho GTPase activating protein 19

chr4_-_166034003 1.563 NM_001100389
TMEM192
transmembrane protein 192
chr6_-_117747017 1.542 NM_002944
ROS1
c-ros oncogene 1 , receptor tyrosine kinase
chr1_+_168545710 1.535 NM_002995
XCL1
chemokine (C motif) ligand 1
chr9_+_79056581 1.535 NM_001097634
GCNT1
glucosaminyl (N-acetyl) transferase 1, core 2
chr19_+_16830786 1.526 NM_001007525
NWD1
NACHT and WD repeat domain containing 1
chr17_+_7462064 1.522 TNFSF13
tumor necrosis factor (ligand) superfamily, member 13

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
3.78 1.13e-03 GO:0006936 muscle contraction
2.13 2.04e-03 GO:0006955 immune response
1.84 2.28e-03 GO:0002376 immune system process
1.45 2.34e-03 GO:0007165 signal transduction
11.01 2.94e-03 GO:0046058 cAMP metabolic process
1.28 3.82e-03 GO:0050896 response to stimulus
1.23 3.96e-03 GO:0065007 biological regulation
3.48 4.14e-03 GO:0003012 muscle system process
1.24 7.01e-03 GO:0050789 regulation of biological process
1.31 8.96e-03 GO:0032501 multicellular organismal process
1.39 1.21e-02 GO:0023052 signaling
3.21 1.31e-02 GO:0055074 calcium ion homeostasis
3.10 2.24e-02 GO:0072507 divalent inorganic cation homeostasis
1.34 2.95e-02 GO:0051716 cellular response to stimulus
1.23 2.96e-02 GO:0050794 regulation of cellular process
1.57 3.00e-02 GO:0048583 regulation of response to stimulus
3.15 3.04e-02 GO:0006874 cellular calcium ion homeostasis
1.59 4.54e-02 GO:0003008 system process
3.05 4.75e-02 GO:0072503 cellular divalent inorganic cation homeostasis

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.53 2.33e-03 GO:0044459 plasma membrane part
1.68 8.73e-03 GO:0031226 intrinsic to plasma membrane
1.69 9.33e-03 GO:0005887 integral to plasma membrane
1.31 1.91e-02 GO:0071944 cell periphery
1.31 1.95e-02 GO:0005886 plasma membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
10.48 1.90e-04 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
10.06 2.71e-04 GO:0004112 cyclic-nucleotide phosphodiesterase activity
11.79 2.51e-03 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity
14.30 5.16e-03 GO:0030553 cGMP binding
13.10 8.61e-03 GO:0019002 GMP binding
5.85 2.20e-02 GO:0008307 structural constituent of muscle
3.93 4.31e-02 GO:0008081 phosphoric diester hydrolase activity