Motif ID: NFE2.p2

Z-value: 1.069


Transcription factors associated with NFE2.p2:

Gene SymbolEntrez IDGene Name
NFE2 4778 nuclear factor (erythroid-derived 2), 45kDa

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NFE2chr12_-_54694717,
chr12_-_54689536,
chr12_-_54694647
-0.045.7e-01Click!


Activity profile for motif NFE2.p2.

activity profile for motif NFE2.p2


Sorted Z-values histogram for motif NFE2.p2

Sorted Z-values for motif NFE2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFE2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_223889253 58.343 NM_001146068
CAPN2
calpain 2, (m/II) large subunit
chr14_+_58711599 34.969 PSMA3
proteasome (prosome, macropain) subunit, alpha type, 3
chr17_+_30771520 33.274 PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr6_-_31704070 19.958 CLIC1
chloride intracellular channel 1
chr3_+_183894736 19.601 AP2M1
adaptor-related protein complex 2, mu 1 subunit
chr6_-_31704318 17.903 NM_001288
CLIC1
chloride intracellular channel 1
chr6_-_31704304 17.433 CLIC1
chloride intracellular channel 1
chr11_-_65667858 17.413 FOSL1
FOS-like antigen 1
chr6_-_31704093 17.275 CLIC1
chloride intracellular channel 1
chr14_+_58711555 17.235 PSMA3
proteasome (prosome, macropain) subunit, alpha type, 3
chr6_-_31704281 17.134 CLIC1
chloride intracellular channel 1
chr6_-_31704272 17.042 CLIC1
chloride intracellular channel 1
chr14_+_58711457 17.026 NM_002788
NM_152132
PSMA3

proteasome (prosome, macropain) subunit, alpha type, 3

chr6_-_31704287 16.977 CLIC1
chloride intracellular channel 1
chr17_+_30771494 16.694 NM_002815
PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr11_-_65667809 16.689 FOSL1
FOS-like antigen 1
chr17_+_30771522 16.580 PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr17_+_30771485 16.476 PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr1_+_40735749 16.173 ZMPSTE24
zinc metallopeptidase (STE24 homolog, S. cerevisiae)
chr11_-_16996559 15.917 RPL36A
ribosomal protein L36a
chr11_-_65667860 15.708 NM_005438
FOSL1
FOS-like antigen 1
chr17_+_30771532 15.007 PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr11_-_14541867 14.926 PSMA1
proteasome (prosome, macropain) subunit, alpha type, 1
chr1_-_109969058 14.298 NM_001199772
NM_002790
NM_001199773
NM_001199774
PSMA5



proteasome (prosome, macropain) subunit, alpha type, 5



chr11_-_14541886 14.095 NM_001143937
NM_002786
PSMA1

proteasome (prosome, macropain) subunit, alpha type, 1

chr16_-_69760444 13.935 NM_000903
NM_001025433
NM_001025434
NQO1


NAD(P)H dehydrogenase, quinone 1


chr2_+_162164785 13.717 NM_005805
PSMD14
proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
chr17_-_73150769 13.643 NM_001002032
NM_001002033
NM_016185
HN1


hematological and neurological expressed 1


chrX_-_15511710 13.088 NM_001018109
NM_003662
PIR

pirin (iron-binding nuclear protein)

chr5_+_72143993 13.042 TNPO1
transportin 1
chr1_-_109969044 12.951 PSMA5
proteasome (prosome, macropain) subunit, alpha type, 5
chr3_+_50284325 12.913 NM_001166425
GNAI2
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
chr1_-_225616556 12.896 NM_194442
LBR
lamin B receptor
chr1_-_45987548 12.592 NM_002574
NM_181696
NM_181697
PRDX1


peroxiredoxin 1


chr11_+_35160385 12.251 NM_000610
NM_001001389
NM_001001390
NM_001001391
NM_001001392
NM_001202555
NM_001202556
NM_001202557
CD44







CD44 molecule (Indian blood group)







chr10_+_17270257 12.248 NM_003380
VIM
vimentin
chr3_-_98241357 12.040 CLDND1
claudin domain containing 1
chr1_+_223900061 11.877 NM_001748
CAPN2
calpain 2, (m/II) large subunit
chrX_-_153285334 11.649 NM_001025242
NM_001025243
NM_001569
IRAK1


interleukin-1 receptor-associated kinase 1


chr17_-_65362635 11.560 PSMD12
proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
chr4_+_41258941 11.017 UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr16_+_74330660 10.993 NM_002811
PSMD7
proteasome (prosome, macropain) 26S subunit, non-ATPase, 7
chr19_-_41859253 10.904 TGFB1
transforming growth factor, beta 1
chr2_+_231921595 10.512 PSMD1
proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
chr5_+_159436143 10.372 TTC1
tetratricopeptide repeat domain 1
chr1_-_109968951 10.270 PSMA5
proteasome (prosome, macropain) subunit, alpha type, 5
chr17_-_79881304 10.212 NM_032711
MAFG
v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian)
chr3_-_149095333 10.136 TM4SF1
transmembrane 4 L six family member 1
chr1_-_154943001 10.005 NM_001130040
NM_183001
SHC1

SHC (Src homology 2 domain containing) transforming protein 1

chr10_+_17270469 9.966 VIM
vimentin
chr1_+_223900226 9.944 CAPN2
calpain 2, (m/II) large subunit
chr7_-_134854225 9.771 NM_001243753
NM_001243755
C7orf49

chromosome 7 open reading frame 49

chr1_-_8931634 9.726 NM_001201483
ENO1
enolase 1, (alpha)
chr9_-_127177689 9.653 NM_002799
PSMB7
proteasome (prosome, macropain) subunit, beta type, 7
chr9_-_113018711 9.556 TXN
thioredoxin
chr15_-_60690115 9.550 NM_001002857
NM_001002858
NM_001136015
NM_004039
ANXA2



annexin A2



chr1_+_110546569 9.505 NM_001242675
NM_001242676
AHCYL1

adenosylhomocysteinase-like 1

chrX_-_153285262 9.430 IRAK1
interleukin-1 receptor-associated kinase 1
chr9_+_33026482 9.425 DNAJA1
DnaJ (Hsp40) homolog, subfamily A, member 1
chr8_-_12973752 9.204 NM_001164271
DLC1
deleted in liver cancer 1
chrX_-_15511358 9.189 PIR
pirin (iron-binding nuclear protein)
chr5_+_72143929 9.151 NM_153188
TNPO1
transportin 1
chr7_+_112063131 9.113 NM_001007245
NM_001197080
IFRD1

interferon-related developmental regulator 1

chr16_+_30076993 9.086 NM_001243177
NM_184041
ALDOA

aldolase A, fructose-bisphosphate

chr3_-_98241683 9.012 CLDND1
claudin domain containing 1
chr16_+_30077120 9.005 ALDOA
aldolase A, fructose-bisphosphate
chr6_+_44214786 8.987 NM_007355
HSP90AB1
heat shock protein 90kDa alpha (cytosolic), class B member 1
chr9_-_113018869 8.956 NM_001244938
NM_003329
TXN

thioredoxin

chr7_+_26331493 8.908 NM_001199835
NM_013322
SNX10

sorting nexin 10

chr17_-_76921453 8.865 NM_003255
TIMP2
TIMP metallopeptidase inhibitor 2
chr12_-_76478347 8.852 NAP1L1
nucleosome assembly protein 1-like 1
chr1_+_36621751 8.795 NM_018067
MAP7D1
MAP7 domain containing 1
chr3_-_149095413 8.670 TM4SF1
transmembrane 4 L six family member 1
chr16_+_30077146 8.661 ALDOA
aldolase A, fructose-bisphosphate
chr7_+_116312412 8.618 NM_000245
NM_001127500
MET

met proto-oncogene (hepatocyte growth factor receptor)

chr3_+_69915374 8.613 NM_198177
MITF
microphthalmia-associated transcription factor
chr17_-_65362667 8.604 NM_002816
NM_174871
PSMD12

proteasome (prosome, macropain) 26S subunit, non-ATPase, 12

chr1_-_94374949 8.539 GCLM
glutamate-cysteine ligase, modifier subunit
chr14_+_39649711 8.537 PNN
pinin, desmosome associated protein
chr2_+_231921625 8.487 PSMD1
proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
chr9_-_113018802 8.369 TXN
thioredoxin
chr17_-_38721701 8.309 NM_001838
CCR7
chemokine (C-C motif) receptor 7
chr6_+_44214853 8.290 HSP90AB1
heat shock protein 90kDa alpha (cytosolic), class B member 1
chr21_+_33031932 8.218 NM_000454
SOD1
superoxide dismutase 1, soluble
chr17_+_18625335 8.182 NM_001037330
TRIM16L
tripartite motif containing 16-like
chr7_+_26331611 8.162 SNX10
sorting nexin 10
chr3_-_149095458 8.079 TM4SF1
transmembrane 4 L six family member 1
chr1_+_174844655 8.016 NM_001035230
RABGAP1L
RAB GTPase activating protein 1-like
chr11_-_47447457 7.978 PSMC3
proteasome (prosome, macropain) 26S subunit, ATPase, 3
chr2_-_85641153 7.931 CAPG
capping protein (actin filament), gelsolin-like
chr9_-_117880411 7.921 NM_002160
TNC
tenascin C
chr6_-_24877453 7.828 NM_015864
FAM65B
family with sequence similarity 65, member B
chr11_+_35160666 7.759 CD44
CD44 molecule (Indian blood group)
chr11_+_118958696 7.732 NM_001024382
HMBS
hydroxymethylbilane synthase
chr11_-_58343308 7.729 NM_004811
LPXN
leupaxin
chr6_+_34206567 7.698 NM_145905
HMGA1
high mobility group AT-hook 1
chr17_-_76921205 7.689 TIMP2
TIMP metallopeptidase inhibitor 2
chr6_-_38670915 7.689 GLO1
glyoxalase I
chr14_+_103801160 7.652 NM_183004
EIF5
eukaryotic translation initiation factor 5
chr6_+_44195008 7.627 SLC29A1
solute carrier family 29 (nucleoside transporters), member 1
chr2_-_85641128 7.618 CAPG
capping protein (actin filament), gelsolin-like
chr1_-_94374986 7.599 NM_002061
GCLM
glutamate-cysteine ligase, modifier subunit
chr6_-_38670904 7.559 GLO1
glyoxalase I
chr6_-_38670871 7.538 GLO1
glyoxalase I
chr6_+_64231626 7.465 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr6_-_24667127 7.441 TDP2
tyrosyl-DNA phosphodiesterase 2
chr1_+_156084565 7.398 LMNA
lamin A/C
chr18_+_55888799 7.385 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr3_-_98241748 7.378 CLDND1
claudin domain containing 1
chr22_-_45608232 7.370 KIAA0930
KIAA0930
chr3_+_141043054 7.360 NM_001080412
ZBTB38
zinc finger and BTB domain containing 38
chr18_+_55888838 7.281 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr5_-_137911039 7.143 HSPA9
heat shock 70kDa protein 9 (mortalin)
chr6_-_170862326 7.132 PSMB1
proteasome (prosome, macropain) subunit, beta type, 1
chr6_-_38670882 7.122 GLO1
glyoxalase I
chr14_+_73525267 7.041 RBM25
RNA binding motif protein 25
chr5_-_137911005 6.941 HSPA9
heat shock 70kDa protein 9 (mortalin)
chr4_+_74606222 6.900 NM_000584
IL8
interleukin 8
chr7_+_143058794 6.898 ZYX
zyxin
chr1_+_36621457 6.893 MAP7D1
MAP7 domain containing 1
chr15_+_89182038 6.805 NM_002201
ISG20
interferon stimulated exonuclease gene 20kDa
chr11_-_47447779 6.723 PSMC3
proteasome (prosome, macropain) 26S subunit, ATPase, 3
chr3_+_184016985 6.622 NM_002808
PSMD2
proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
chrX_-_129244471 6.603 NM_001421
ELF4
E74-like factor 4 (ets domain transcription factor)
chr14_+_73525187 6.603 NM_021239
RBM25
RNA binding motif protein 25
chr12_+_56522043 6.557 ESYT1
extended synaptotagmin-like protein 1
chr7_-_96339074 6.460 SHFM1
split hand/foot malformation (ectrodactyly) type 1
chr12_+_56522202 6.451 ESYT1
extended synaptotagmin-like protein 1
chr19_-_41858948 6.450 TGFB1
transforming growth factor, beta 1
chr5_+_159436155 6.445 NM_003314
TTC1
tetratricopeptide repeat domain 1
chr6_-_159239269 6.392 NM_003379
EZR
ezrin
chr6_-_24666818 6.388 NM_016614
TDP2
tyrosyl-DNA phosphodiesterase 2
chr1_-_36107032 6.383 PSMB2
proteasome (prosome, macropain) subunit, beta type, 2
chr12_-_56359794 6.360 NM_001200053
NM_001200054
PMEL

premelanosome protein

chr12_+_56521953 6.343 NM_001184796
NM_015292
ESYT1

extended synaptotagmin-like protein 1

chr16_+_89988416 6.335 NM_001197181
TUBB3
tubulin, beta 3 class III
chr5_+_179247841 6.302 NM_003900
SQSTM1
sequestosome 1
chr6_-_38670829 6.299 GLO1
glyoxalase I
chr12_-_76478410 6.205 NAP1L1
nucleosome assembly protein 1-like 1
chr12_+_56522049 6.167 ESYT1
extended synaptotagmin-like protein 1
chrX_+_47441650 6.019 NM_003254
TIMP1
TIMP metallopeptidase inhibitor 1
chr12_-_57081961 5.978 PTGES3
prostaglandin E synthase 3 (cytosolic)
chr7_+_22766765 5.976 NM_000600
IL6
interleukin 6 (interferon, beta 2)
chr6_-_84140758 5.950 ME1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr3_+_184017038 5.945 PSMD2
proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
chr6_-_159239198 5.942 EZR
ezrin
chr4_-_139163222 5.936 NM_014331
SLC7A11
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
chr1_+_228332403 5.933 NM_001159391
GUK1
guanylate kinase 1
chr3_+_105085553 5.895 NM_001243280
NM_001243281
NM_001243283
NM_001627
ALCAM



activated leukocyte cell adhesion molecule



chr12_-_57081923 5.889 PTGES3
prostaglandin E synthase 3 (cytosolic)
chr11_-_47447915 5.884 NM_002804
PSMC3
proteasome (prosome, macropain) 26S subunit, ATPase, 3
chr5_+_179247911 5.847 SQSTM1
sequestosome 1
chr4_+_77953942 5.835 SEPT11
septin 11
chr6_+_24667262 5.781 NM_001160094
NM_018473
ACOT13

acyl-CoA thioesterase 13

chr19_-_10450262 5.746 NM_002162
ICAM3
intercellular adhesion molecule 3
chr14_+_103800678 5.673 EIF5
eukaryotic translation initiation factor 5
chr11_+_35160815 5.628 CD44
CD44 molecule (Indian blood group)
chr20_+_33759773 5.615 NM_006404
PROCR
protein C receptor, endothelial
chr5_+_10353980 5.589


chr14_+_73525302 5.573 RBM25
RNA binding motif protein 25
chr11_-_102668822 5.570 MMP1
matrix metallopeptidase 1 (interstitial collagenase)
chr1_+_76251878 5.549 NM_004582
RABGGTB
Rab geranylgeranyltransferase, beta subunit
chr12_-_76478737 5.547 NM_004537
NM_139207
NAP1L1

nucleosome assembly protein 1-like 1

chr12_+_64798050 5.533 NM_007235
XPOT
exportin, tRNA (nuclear export receptor for tRNAs)
chr3_+_100238063 5.519 TMEM45A
transmembrane protein 45A
chrX_-_99987072 5.519 NM_001129896
SYTL4
synaptotagmin-like 4
chr11_-_3862137 5.515 RHOG
ras homolog gene family, member G (rho G)
chr2_+_162164993 5.487 PSMD14
proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
chr6_-_159239254 5.465 EZR
ezrin
chr6_-_170862379 5.463 NM_002793
PSMB1
proteasome (prosome, macropain) subunit, beta type, 1
chr1_-_94375028 5.416 GCLM
glutamate-cysteine ligase, modifier subunit
chr7_+_100770378 5.363 NM_000602
NM_001165413
SERPINE1

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

chr11_-_6640644 5.342 TPP1
tripeptidyl peptidase I
chr11_-_6640661 5.321 NM_000391
TPP1
tripeptidyl peptidase I
chr2_-_216259197 5.316 FN1
fibronectin 1
chr10_+_131934674 5.275 GLRX3
glutaredoxin 3
chr1_-_246580710 5.264 NM_022743
SMYD3
SET and MYND domain containing 3
chr19_+_36630999 5.252 CAPNS1
calpain, small subunit 1
chr10_+_85899184 5.250 NM_014394
GHITM
growth hormone inducible transmembrane protein
chr3_-_149095517 5.241 NM_014220
TM4SF1
transmembrane 4 L six family member 1
chr6_-_84140744 5.227 ME1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr5_+_179247903 5.202 SQSTM1
sequestosome 1
chr21_+_30517897 5.118 C21orf7
chromosome 21 open reading frame 7
chr8_-_102217907 5.095 NM_001042510
NM_016096
ZNF706

zinc finger protein 706

chr12_-_57082056 5.064 NM_006601
PTGES3
prostaglandin E synthase 3 (cytosolic)
chr10_+_121411086 5.054 BAG3
BCL2-associated athanogene 3
chr11_-_6640645 5.001 TPP1
tripeptidyl peptidase I
chr11_-_102668892 4.992 NM_001145938
NM_002421
MMP1

matrix metallopeptidase 1 (interstitial collagenase)

chr18_+_55888750 4.972 NM_001144966
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr8_-_30585442 4.939 NM_000637
NM_001195102
NM_001195103
NM_001195104
GSR



glutathione reductase



chr1_+_81771844 4.894 LPHN2
latrophilin 2
chr11_+_35160832 4.866 CD44
CD44 molecule (Indian blood group)
chr11_+_67351276 4.858 GSTP1
glutathione S-transferase pi 1
chr7_+_143078358 4.854 NM_001010972
NM_003461
ZYX

zyxin

chr1_+_156084541 4.846 LMNA
lamin A/C
chr19_+_36631001 4.844 CAPNS1
calpain, small subunit 1
chr7_+_143078447 4.805 ZYX
zyxin
chr11_+_67351065 4.800 NM_000852
GSTP1
glutathione S-transferase pi 1
chr20_+_48807365 4.792 CEBPB
CCAAT/enhancer binding protein (C/EBP), beta
chr7_+_148395886 4.764 NM_003592
CUL1
cullin 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.27 1.08e-16 GO:0009987 cellular process
2.03 1.03e-15 GO:0048522 positive regulation of cellular process
1.95 1.50e-15 GO:0048518 positive regulation of biological process
2.00 9.28e-15 GO:0006950 response to stress
2.65 4.21e-14 GO:0043067 regulation of programmed cell death
2.65 7.78e-14 GO:0042981 regulation of apoptosis
2.61 1.14e-13 GO:0010941 regulation of cell death
1.49 2.96e-13 GO:0050896 response to stimulus
1.44 4.36e-13 GO:0050794 regulation of cellular process
2.56 4.38e-13 GO:0051246 regulation of protein metabolic process
1.65 7.77e-13 GO:0051716 cellular response to stimulus
1.38 2.64e-12 GO:0065007 biological regulation
2.54 8.54e-12 GO:0032268 regulation of cellular protein metabolic process
1.39 1.36e-11 GO:0050789 regulation of biological process
10.06 2.03e-11 GO:0006521 regulation of cellular amino acid metabolic process
8.77 8.29e-11 GO:0071158 positive regulation of cell cycle arrest
2.66 1.64e-10 GO:0044093 positive regulation of molecular function
8.74 3.88e-10 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
8.74 3.88e-10 GO:0072395 signal transduction involved in cell cycle checkpoint
8.74 3.88e-10 GO:0072401 signal transduction involved in DNA integrity checkpoint
8.74 3.88e-10 GO:0072404 signal transduction involved in G1/S transition checkpoint
8.74 3.88e-10 GO:0072413 signal transduction involved in mitotic cell cycle checkpoint
8.74 3.88e-10 GO:0072422 signal transduction involved in DNA damage checkpoint
8.74 3.88e-10 GO:0072431 signal transduction involved in mitotic cell cycle G1/S transition DNA damage checkpoint
8.74 3.88e-10 GO:0072474 signal transduction involved in mitotic cell cycle G1/S checkpoint
2.65 3.90e-10 GO:0031399 regulation of protein modification process
1.67 4.52e-10 GO:0007165 signal transduction
2.23 1.03e-09 GO:0009893 positive regulation of metabolic process
8.33 1.03e-09 GO:0033238 regulation of cellular amine metabolic process
2.74 1.15e-09 GO:0043085 positive regulation of catalytic activity
7.19 1.52e-09 GO:2000045 regulation of G1/S transition of mitotic cell cycle
2.27 2.87e-09 GO:0010604 positive regulation of macromolecule metabolic process
7.84 3.46e-09 GO:0031571 mitotic cell cycle G1/S transition DNA damage checkpoint
6.85 4.16e-09 GO:0030330 DNA damage response, signal transduction by p53 class mediator
1.41 4.76e-09 GO:0044237 cellular metabolic process
7.19 5.24e-09 GO:0031575 mitotic cell cycle G1/S transition checkpoint
7.19 5.24e-09 GO:0071779 G1/S transition checkpoint
7.51 8.09e-09 GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
1.59 9.37e-09 GO:0023052 signaling
2.43 1.17e-08 GO:0051704 multi-organism process
2.20 1.29e-08 GO:0031325 positive regulation of cellular metabolic process
6.84 1.44e-08 GO:0051351 positive regulation of ligase activity
2.60 1.77e-08 GO:0012501 programmed cell death
3.32 2.00e-08 GO:0032270 positive regulation of cellular protein metabolic process
3.63 2.57e-08 GO:0031401 positive regulation of protein modification process
7.54 2.79e-08 GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
2.60 2.80e-08 GO:0006915 apoptosis
6.92 3.88e-08 GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
2.14 4.23e-08 GO:0002376 immune system process
6.83 4.96e-08 GO:0000216 M/G1 transition of mitotic cell cycle
6.83 4.96e-08 GO:0051443 positive regulation of ubiquitin-protein ligase activity
1.76 5.50e-08 GO:0048519 negative regulation of biological process
7.21 6.25e-08 GO:0051352 negative regulation of ligase activity
7.21 6.25e-08 GO:0051444 negative regulation of ubiquitin-protein ligase activity
2.16 6.41e-08 GO:0050790 regulation of catalytic activity
6.66 8.01e-08 GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
3.17 9.09e-08 GO:0051247 positive regulation of protein metabolic process
5.06 1.12e-07 GO:0010565 regulation of cellular ketone metabolic process
2.35 1.16e-07 GO:0009611 response to wounding
2.09 1.38e-07 GO:0010033 response to organic substance
5.97 2.09e-07 GO:0051340 regulation of ligase activity
5.61 2.44e-07 GO:0090068 positive regulation of cell cycle process
4.85 2.93e-07 GO:0000082 G1/S transition of mitotic cell cycle
1.75 3.05e-07 GO:0042221 response to chemical stimulus
2.72 3.24e-07 GO:0050878 regulation of body fluid levels
1.77 3.27e-07 GO:0048523 negative regulation of cellular process
5.51 3.55e-07 GO:0042770 signal transduction in response to DNA damage
2.86 3.63e-07 GO:0007599 hemostasis
5.46 4.26e-07 GO:0000084 S phase of mitotic cell cycle
5.46 4.26e-07 GO:0031398 positive regulation of protein ubiquitination
2.33 4.40e-07 GO:0008219 cell death
4.56 4.76e-07 GO:0010498 proteasomal protein catabolic process
4.56 4.76e-07 GO:0043161 proteasomal ubiquitin-dependent protein catabolic process
2.32 5.44e-07 GO:0016265 death
5.36 6.09e-07 GO:0051320 S phase
2.26 6.18e-07 GO:0070887 cellular response to chemical stimulus
1.32 6.34e-07 GO:0008152 metabolic process
5.92 7.11e-07 GO:0051438 regulation of ubiquitin-protein ligase activity
1.36 7.99e-07 GO:0044238 primary metabolic process
2.81 9.50e-07 GO:0007596 blood coagulation
2.81 9.50e-07 GO:0050817 coagulation
3.27 9.71e-07 GO:0051603 proteolysis involved in cellular protein catabolic process
3.66 1.04e-06 GO:0051248 negative regulation of protein metabolic process
2.62 1.15e-06 GO:0042060 wound healing
3.69 1.55e-06 GO:0032269 negative regulation of cellular protein metabolic process
3.21 1.65e-06 GO:0044257 cellular protein catabolic process
5.29 2.02e-06 GO:0000077 DNA damage checkpoint
1.50 2.14e-06 GO:0019222 regulation of metabolic process
5.81 2.94e-06 GO:0031397 negative regulation of protein ubiquitination
4.35 2.95e-06 GO:0031400 negative regulation of protein modification process
3.08 2.95e-06 GO:0030163 protein catabolic process
1.55 3.24e-06 GO:0060255 regulation of macromolecule metabolic process
1.96 3.65e-06 GO:0035556 intracellular signal transduction
1.90 6.02e-06 GO:0065009 regulation of molecular function
4.75 6.03e-06 GO:0007093 mitotic cell cycle checkpoint
4.97 6.50e-06 GO:0031570 DNA integrity checkpoint
2.24 9.94e-06 GO:0033554 cellular response to stress
1.55 1.09e-05 GO:0034641 cellular nitrogen compound metabolic process
2.84 1.14e-05 GO:0043086 negative regulation of catalytic activity
1.54 1.16e-05 GO:0006807 nitrogen compound metabolic process
2.31 1.16e-05 GO:0006955 immune response
4.38 1.24e-05 GO:0031396 regulation of protein ubiquitination
1.50 1.64e-05 GO:0080090 regulation of primary metabolic process
1.63 2.02e-05 GO:0044267 cellular protein metabolic process
3.08 2.41e-05 GO:0019941 modification-dependent protein catabolic process
2.11 2.42e-05 GO:0042127 regulation of cell proliferation
2.56 2.82e-05 GO:0044265 cellular macromolecule catabolic process
3.06 2.84e-05 GO:0043632 modification-dependent macromolecule catabolic process
2.93 3.01e-05 GO:0044419 interspecies interaction between organisms
1.55 3.73e-05 GO:0019538 protein metabolic process
2.41 4.21e-05 GO:0009057 macromolecule catabolic process
3.04 5.20e-05 GO:0006511 ubiquitin-dependent protein catabolic process
3.07 6.87e-05 GO:0034097 response to cytokine stimulus
1.48 7.74e-05 GO:0031323 regulation of cellular metabolic process
2.28 8.26e-05 GO:0019220 regulation of phosphate metabolic process
2.28 8.26e-05 GO:0051174 regulation of phosphorus metabolic process
2.30 8.42e-05 GO:0042325 regulation of phosphorylation
1.56 1.01e-04 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.41 1.08e-04 GO:0044260 cellular macromolecule metabolic process
2.31 1.46e-04 GO:0071310 cellular response to organic substance
2.47 1.59e-04 GO:0044092 negative regulation of molecular function
2.50 1.73e-04 GO:0009607 response to biotic stimulus
2.49 1.84e-04 GO:0043065 positive regulation of apoptosis
2.31 2.14e-04 GO:0001932 regulation of protein phosphorylation
2.48 2.20e-04 GO:0043068 positive regulation of programmed cell death
1.80 2.40e-04 GO:0009056 catabolic process
3.11 2.57e-04 GO:0007346 regulation of mitotic cell cycle
1.47 3.42e-04 GO:0016043 cellular component organization
2.43 3.49e-04 GO:0010942 positive regulation of cell death
1.36 3.50e-04 GO:0043170 macromolecule metabolic process
1.88 5.32e-04 GO:0044248 cellular catabolic process
2.28 5.32e-04 GO:0009725 response to hormone stimulus
2.35 6.45e-04 GO:0006928 cellular component movement
2.41 9.36e-04 GO:0001775 cell activation
1.94 1.19e-03 GO:0032879 regulation of localization
2.17 1.21e-03 GO:0009719 response to endogenous stimulus
1.43 1.63e-03 GO:0071840 cellular component organization or biogenesis
1.58 1.67e-03 GO:0065008 regulation of biological quality
3.68 2.20e-03 GO:0030335 positive regulation of cell migration
3.68 2.20e-03 GO:2000147 positive regulation of cell motility
2.80 2.23e-03 GO:0051329 interphase of mitotic cell cycle
3.16 2.49e-03 GO:0000075 cell cycle checkpoint
5.14 2.54e-03 GO:0071216 cellular response to biotic stimulus
3.06 2.66e-03 GO:0030168 platelet activation
2.75 3.16e-03 GO:0051325 interphase
4.38 3.23e-03 GO:0042176 regulation of protein catabolic process
2.86 3.51e-03 GO:0048545 response to steroid hormone stimulus
3.55 3.71e-03 GO:0040017 positive regulation of locomotion
2.79 3.73e-03 GO:0042493 response to drug
2.33 4.05e-03 GO:0043549 regulation of kinase activity
3.85 4.31e-03 GO:0031960 response to corticosteroid stimulus
2.28 4.67e-03 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
2.38 4.76e-03 GO:0060548 negative regulation of cell death
3.04 4.85e-03 GO:0071156 regulation of cell cycle arrest
2.44 5.18e-03 GO:0051707 response to other organism
1.65 5.39e-03 GO:0023051 regulation of signaling
1.63 5.66e-03 GO:0016070 RNA metabolic process
2.26 6.02e-03 GO:0008284 positive regulation of cell proliferation
3.44 6.09e-03 GO:0051272 positive regulation of cellular component movement
3.09 6.39e-03 GO:0006916 anti-apoptosis
2.42 6.50e-03 GO:0007243 intracellular protein kinase cascade
2.42 6.50e-03 GO:0023014 signal transduction via phosphorylation event
2.38 6.57e-03 GO:0043069 negative regulation of programmed cell death
1.96 6.79e-03 GO:0006508 proteolysis
3.56 6.85e-03 GO:0002237 response to molecule of bacterial origin
3.90 7.05e-03 GO:0051384 response to glucocorticoid stimulus
3.70 7.49e-03 GO:0032496 response to lipopolysaccharide
2.25 9.19e-03 GO:0051338 regulation of transferase activity
2.30 1.06e-02 GO:0045859 regulation of protein kinase activity
1.88 1.19e-02 GO:0010605 negative regulation of macromolecule metabolic process
1.39 1.39e-02 GO:0051179 localization
2.33 1.40e-02 GO:0043066 negative regulation of apoptosis
2.21 1.43e-02 GO:0006974 response to DNA damage stimulus
1.90 1.67e-02 GO:0009891 positive regulation of biosynthetic process
1.58 1.72e-02 GO:0007166 cell surface receptor linked signaling pathway
2.00 1.85e-02 GO:0002682 regulation of immune system process
1.96 1.95e-02 GO:0010557 positive regulation of macromolecule biosynthetic process
1.46 2.04e-02 GO:0071842 cellular component organization at cellular level
1.66 2.34e-02 GO:0009966 regulation of signal transduction
1.50 2.41e-02 GO:0090304 nucleic acid metabolic process
2.21 2.47e-02 GO:0006461 protein complex assembly
4.19 2.65e-02 GO:0010952 positive regulation of peptidase activity
1.80 2.75e-02 GO:0009892 negative regulation of metabolic process
1.55 2.80e-02 GO:0048583 regulation of response to stimulus
2.61 2.85e-02 GO:0051270 regulation of cellular component movement
2.19 2.85e-02 GO:0070271 protein complex biogenesis
2.89 3.00e-02 GO:0071345 cellular response to cytokine stimulus
2.35 3.13e-02 GO:0010627 regulation of intracellular protein kinase cascade
2.13 3.15e-02 GO:0016071 mRNA metabolic process
2.65 3.21e-02 GO:0010740 positive regulation of intracellular protein kinase cascade
2.03 3.39e-02 GO:0051726 regulation of cell cycle
4.10 3.41e-02 GO:0000302 response to reactive oxygen species
2.01 3.43e-02 GO:0007167 enzyme linked receptor protein signaling pathway
1.83 3.67e-02 GO:0031324 negative regulation of cellular metabolic process
2.29 3.84e-02 GO:0016477 cell migration
2.92 4.02e-02 GO:0043405 regulation of MAP kinase activity
2.22 4.06e-02 GO:0048870 cell motility
2.22 4.06e-02 GO:0051674 localization of cell
2.67 4.38e-02 GO:0030334 regulation of cell migration
1.86 4.53e-02 GO:0031328 positive regulation of cellular biosynthetic process
3.22 4.78e-02 GO:0050900 leukocyte migration

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
9.80 4.25e-14 GO:0000502 proteasome complex
1.33 6.60e-12 GO:0005737 cytoplasm
1.75 1.72e-07 GO:0005829 cytosol
1.57 7.40e-07 GO:0043234 protein complex
1.17 2.38e-06 GO:0044424 intracellular part
1.33 6.40e-06 GO:0044444 cytoplasmic part
1.16 1.19e-05 GO:0005622 intracellular
1.45 4.53e-05 GO:0032991 macromolecular complex
14.03 4.83e-04 GO:0022624 proteasome accessory complex
1.79 1.09e-03 GO:0000267 cell fraction
9.82 1.15e-03 GO:0005839 proteasome core complex
15.59 1.98e-03 GO:0005838 proteasome regulatory particle
1.85 5.07e-03 GO:0005626 insoluble fraction
5.37 1.12e-02 GO:0031093 platelet alpha granule lumen
5.26 1.34e-02 GO:0034774 secretory granule lumen
1.80 1.78e-02 GO:0005624 membrane fraction
5.05 1.87e-02 GO:0060205 cytoplasmic membrane-bounded vesicle lumen
1.79 2.24e-02 GO:0031982 vesicle
4.86 2.58e-02 GO:0031983 vesicle lumen
1.78 4.00e-02 GO:0031410 cytoplasmic vesicle

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.48 2.09e-19 GO:0005515 protein binding
1.17 1.55e-07 GO:0005488 binding
3.43 2.27e-04 GO:0005126 cytokine receptor binding
2.06 3.21e-04 GO:0019899 enzyme binding
9.35 2.46e-03 GO:0004298 threonine-type endopeptidase activity
9.35 2.46e-03 GO:0070003 threonine-type peptidase activity
7.24 4.42e-03 GO:0015036 disulfide oxidoreductase activity
2.58 1.07e-02 GO:0032403 protein complex binding
1.25 2.23e-02 GO:0003824 catalytic activity
4.95 3.25e-02 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors
1.68 4.47e-02 GO:0005102 receptor binding