Motif ID: NFE2L1.p2

Z-value: 1.506


Transcription factors associated with NFE2L1.p2:

Gene SymbolEntrez IDGene Name
NFE2L1 4779 nuclear factor (erythroid-derived 2)-like 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NFE2L1chr17_+_461256750.511.6e-15Click!


Activity profile for motif NFE2L1.p2.

activity profile for motif NFE2L1.p2


Sorted Z-values histogram for motif NFE2L1.p2

Sorted Z-values for motif NFE2L1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFE2L1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_216259197 16.260 FN1
fibronectin 1
chr5_+_138211084 15.684 CTNNA1
catenin (cadherin-associated protein), alpha 1, 102kDa
chr7_+_75931829 15.587 NM_001540
HSPB1
heat shock 27kDa protein 1
chr3_-_45267068 14.863 TMEM158
transmembrane protein 158 (gene/pseudogene)
chr21_-_27253197 14.669 APP
amyloid beta (A4) precursor protein
chr7_+_75931991 14.388 HSPB1
heat shock 27kDa protein 1
chr21_+_47545896 13.249 COL6A2
collagen, type VI, alpha 2
chrX_-_10535476 13.112 NM_001193278
NM_001193279
NM_001193280
NM_001193281
MID1



midline 1 (Opitz/BBB syndrome)



chr9_+_97521930 12.200 NM_001193329
C9orf3
chromosome 9 open reading frame 3
chr3_+_158991035 11.847 NM_001197107
NM_001197108
NM_014575
SCHIP1


schwannomin interacting protein 1


chr21_+_47545189 10.701 COL6A2
collagen, type VI, alpha 2
chr10_+_102123420 10.563


chr5_+_34684611 10.403 NM_001145521
NM_001145525
RAI14

retinoic acid induced 14

chr1_+_44064509 9.726 PTPRF
protein tyrosine phosphatase, receptor type, F
chr7_+_94292737 9.625 PEG10
paternally expressed 10
chr5_+_140868721 9.117 NM_018929
NM_032407
PCDHGC5

protocadherin gamma subfamily C, 5

chr4_-_139163222 8.967 NM_014331
SLC7A11
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
chr1_+_51701970 8.891 RNF11
ring finger protein 11
chr2_-_106015423 8.798 NM_001039492
NM_001450
NM_201555
FHL2


four and a half LIM domains 2


chr12_+_54422193 8.664 NM_004503
HOXC6
homeobox C6
chr8_+_145066886 8.649 GRINA
glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
chr6_-_10419786 8.369 NM_001042425
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr1_+_51701995 8.364 RNF11
ring finger protein 11
chr1_-_154943001 8.349 NM_001130040
NM_183001
SHC1

SHC (Src homology 2 domain containing) transforming protein 1

chr2_-_47134945 8.075 MCFD2
multiple coagulation factor deficiency 2
chr14_-_103988829 7.455 CKB
creatine kinase, brain
chr11_-_27743604 7.411 NM_170731
BDNF
brain-derived neurotrophic factor
chr7_+_94292816 7.395 PEG10
paternally expressed 10
chrX_+_114827818 7.386 NM_001136025
NM_001172335
PLS3

plastin 3

chr22_+_38597938 7.250 NM_001161572
NM_001161574
NM_012323
MAFF


v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)


chr3_-_127541160 7.237 NM_007283
MGLL
monoglyceride lipase
chr10_-_98325100 7.208 TM9SF3
transmembrane 9 superfamily member 3
chr2_-_55199894 7.123


chr4_+_41700736 6.998 LIMCH1
LIM and calponin homology domains 1
chr22_+_38598065 6.914 MAFF
v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
chr22_-_50720334 6.911 PLXNB2
plexin B2
chr17_-_48264039 6.860 COL1A1
collagen, type I, alpha 1
chrX_-_10645726 6.831 NM_001098624
MID1
midline 1 (Opitz/BBB syndrome)
chr2_+_201473942 6.811 AOX1
aldehyde oxidase 1
chr5_+_140729723 6.716 NM_018922
NM_032095
PCDHGB1

protocadherin gamma subfamily B, 1

chr5_+_102201526 6.569 NM_000919
NM_001177306
NM_138766
NM_138821
NM_138822
PAM




peptidylglycine alpha-amidating monooxygenase




chr5_+_140810181 6.509 PCDHGA12
protocadherin gamma subfamily A, 12
chr5_+_36608430 6.453 NM_001166695
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr6_-_30712294 6.373 NM_003897
IER3
immediate early response 3
chrX_-_99891690 6.349 NM_003270
TSPAN6
tetraspanin 6
chr12_+_78225068 6.322 NM_014903
NAV3
neuron navigator 3
chr1_-_95392449 6.309 CNN3
calponin 3, acidic
chr10_+_75673346 6.067 PLAU
plasminogen activator, urokinase
chr2_-_74601653 6.062 NM_001135041
NM_023019
DCTN1

dynactin 1

chr7_+_116660291 6.061 ST7
suppression of tumorigenicity 7
chr15_-_34394071 6.041 C15orf24
chromosome 15 open reading frame 24
chr5_+_71403040 6.036 NM_005909
MAP1B
microtubule-associated protein 1B
chr1_-_95392501 6.034 NM_001839
CNN3
calponin 3, acidic
chr17_-_40575117 5.871 NM_012232
PTRF
polymerase I and transcript release factor
chr9_-_14313899 5.807 NFIB
nuclear factor I/B
chr22_+_38071612 5.805 NM_002305
LGALS1
lectin, galactoside-binding, soluble, 1
chr2_-_65593866 5.746 NM_001128210
SPRED2
sprouty-related, EVH1 domain containing 2
chr2_-_165551178 5.655 COBLL1
COBL-like 1
chr1_-_68697997 5.636 NM_001002292
NM_001193334
NM_024911
WLS


wntless homolog (Drosophila)


chr12_+_13349601 5.575 NM_001423
EMP1
epithelial membrane protein 1
chr17_-_46682333 5.524 NM_018952
HOXB6
homeobox B6
chr5_+_140753480 5.398 NM_018919
NM_032086
PCDHGA6

protocadherin gamma subfamily A, 6

chr16_+_2564000 5.336 ATP6V0C
ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
chr3_+_69812620 5.306 NM_001184967
MITF
microphthalmia-associated transcription factor
chr17_+_57784961 5.286 VMP1
vacuole membrane protein 1
chr15_-_34394016 5.238 NM_020154
C15orf24
chromosome 15 open reading frame 24
chr17_+_57785011 5.211 VMP1
vacuole membrane protein 1
chr17_+_57785010 5.192 VMP1
vacuole membrane protein 1
chr17_+_57785025 5.189 VMP1
vacuole membrane protein 1
chr9_-_16727887 5.170 BNC2
basonuclin 2
chr12_+_13349720 5.168 EMP1
epithelial membrane protein 1
chr10_+_121410751 5.162 NM_004281
BAG3
BCL2-associated athanogene 3
chr8_+_104831415 5.111 NM_014677
RIMS2
regulating synaptic membrane exocytosis 2
chr10_+_124220990 5.034 NM_002775
HTRA1
HtrA serine peptidase 1
chr10_+_121410891 5.003 BAG3
BCL2-associated athanogene 3
chr5_+_140810126 4.988 NM_003735
NM_032094
PCDHGA12

protocadherin gamma subfamily A, 12

chr12_-_14849427 4.956 NM_004963
GUCY2C
guanylate cyclase 2C (heat stable enterotoxin receptor)
chr1_-_155210887 4.928 GBA
glucosidase, beta, acid
chr12_-_6961044 4.890 CDCA3
cell division cycle associated 3
chr5_+_102201713 4.885 PAM
peptidylglycine alpha-amidating monooxygenase
chr4_+_88896899 4.870 SPP1
secreted phosphoprotein 1
chr17_+_57785059 4.864 VMP1
vacuole membrane protein 1
chr4_+_88896801 4.854 NM_000582
NM_001040058
NM_001040060
NM_001251829
NM_001251830
SPP1




secreted phosphoprotein 1




chr16_+_2563675 4.840 NM_001198569
NM_001694
ATP6V0C

ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c

chr4_-_186577858 4.786 SORBS2
sorbin and SH3 domain containing 2
chr17_-_15168590 4.779 NM_000304
PMP22
peripheral myelin protein 22
chr7_+_5632453 4.762 FSCN1
fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)
chr2_+_46524448 4.744 NM_001430
EPAS1
endothelial PAS domain protein 1
chr10_+_121411071 4.730 BAG3
BCL2-associated athanogene 3
chr4_+_88896868 4.676 SPP1
secreted phosphoprotein 1
chr7_+_134464161 4.668 NM_004342
NM_033138
NM_033157
CALD1


caldesmon 1


chr2_+_109237679 4.663 NM_001193484
LIMS1
LIM and senescent cell antigen-like domains 1
chr5_-_175843360 4.643 CLTB
clathrin, light chain B
chr2_+_108994366 4.614 NM_006588
SULT1C4
sulfotransferase family, cytosolic, 1C, member 4
chr17_+_38137185 4.587 PSMD3
proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
chr4_+_88896838 4.577 SPP1
secreted phosphoprotein 1
chr17_-_48474678 4.559 LRRC59
leucine rich repeat containing 59
chr7_+_134464417 4.549 CALD1
caldesmon 1
chrX_+_102611379 4.516 NM_001006612
NM_001006613
NM_001006614
NM_016303
WBP5



WW domain binding protein 5



chr6_-_3157696 4.515 NM_001069
TUBB2A
tubulin, beta 2A class IIa
chr4_-_186578122 4.503 NM_001145674
NM_001145675
SORBS2

sorbin and SH3 domain containing 2

chr1_+_110560111 4.413 AHCYL1
adenosylhomocysteinase-like 1
chrX_+_70443055 4.379 NM_000166
GJB1
gap junction protein, beta 1, 32kDa
chr2_+_36583369 4.377 NM_016441
CRIM1
cysteine rich transmembrane BMP regulator 1 (chordin-like)
chr11_-_31832784 4.327 PAX6
paired box 6
chr11_-_31832758 4.326 PAX6
paired box 6
chr12_+_12938540 4.313 NM_030817
APOLD1
apolipoprotein L domain containing 1
chr17_-_42992852 4.227 NM_001131019
NM_001242376
NM_002055
GFAP


glial fibrillary acidic protein


chrX_-_13835187 4.221 GPM6B
glycoprotein M6B
chr6_+_7541863 4.169 NM_001008844
NM_004415
DSP

desmoplakin

chr4_-_80994183 4.142


chr10_+_121411042 4.104 BAG3
BCL2-associated athanogene 3
chr7_-_129592711 4.094 NM_001202498
UBE2H
ubiquitin-conjugating enzyme E2H
chr12_+_6647339 4.089 GAPDH
glyceraldehyde-3-phosphate dehydrogenase
chr11_-_6502563 4.087 NM_001242854
NM_001242855
NM_001242856
NM_012402
ARFIP2



ADP-ribosylation factor interacting protein 2



chr12_+_12764844 4.081 CREBL2
cAMP responsive element binding protein-like 2
chr6_-_46047978 4.057 NM_001114086
CLIC5
chloride intracellular channel 5
chr8_-_42065037 4.055 PLAT
plasminogen activator, tissue
chr8_+_132991171 4.049 EFR3A
EFR3 homolog A (S. cerevisiae)
chr5_+_125800786 4.042 NM_001146322
GRAMD3
GRAM domain containing 3
chr17_-_39684585 4.037 NM_002276
KRT19
keratin 19
chr11_-_14386051 4.037 NM_001177314
RRAS2
related RAS viral (r-ras) oncogene homolog 2
chr11_-_6502524 4.031 ARFIP2
ADP-ribosylation factor interacting protein 2
chr17_-_39684499 4.026 KRT19
keratin 19
chr5_+_179132676 4.007 CANX
calnexin
chr17_-_47785527 4.000 SLC35B1
solute carrier family 35, member B1
chr15_+_74218962 3.953 LOXL1
lysyl oxidase-like 1
chr6_+_7541837 3.941 DSP
desmoplakin
chr3_-_149095517 3.940 NM_014220
TM4SF1
transmembrane 4 L six family member 1
chr2_-_33824294 3.940 NM_015475
FAM98A
family with sequence similarity 98, member A
chr11_-_31832592 3.935 PAX6
paired box 6
chr20_+_44520021 3.899 CTSA
cathepsin A
chr7_+_116660263 3.892 ST7
suppression of tumorigenicity 7
chrM_+_4770 3.891


chr8_-_42065193 3.891 NM_000930
NM_033011
PLAT

plasminogen activator, tissue

chr20_+_44519924 3.882 CTSA
cathepsin A
chr20_+_44519590 3.881 NM_000308
NM_001127695
NM_001167594
CTSA


cathepsin A


chr13_+_111154013 3.867 COL4A2
collagen, type IV, alpha 2
chr5_+_140810326 3.862 PCDHGA12
protocadherin gamma subfamily A, 12
chr20_+_44519965 3.850 CTSA
cathepsin A
chr15_+_80364902 3.846 NM_001242915
NM_001242916
ZFAND6

zinc finger, AN1-type domain 6

chr16_+_2563977 3.838 ATP6V0C
ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
chr15_+_96869156 3.831 NM_001145155
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr14_+_67831484 3.826 EIF2S1
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
chr7_+_5632435 3.823 NM_003088
FSCN1
fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)
chr5_-_179229874 3.819 NM_054013
MGAT4B
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B
chr10_+_128593994 3.773 NM_001380
DOCK1
dedicator of cytokinesis 1
chr8_+_38854431 3.771 NM_003816
ADAM9
ADAM metallopeptidase domain 9
chr13_-_45048436 3.765 NM_001243798
TSC22D1
TSC22 domain family, member 1
chr14_+_101295409 3.763 MEG3
maternally expressed 3 (non-protein coding)
chr16_+_2563993 3.737 ATP6V0C
ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
chr22_-_50720961 3.736 PLXNB2
plexin B2
chr10_-_79686279 3.731 NM_004747
DLG5
discs, large homolog 5 (Drosophila)
chr6_+_7541892 3.725 DSP
desmoplakin
chr5_+_161277702 3.720 NM_001127648
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr10_+_5488521 3.709 NM_005863
NET1
neuroepithelial cell transforming 1
chr5_+_125758818 3.685 NM_001146320
NM_001146321
NM_023927
GRAMD3


GRAM domain containing 3


chr3_+_183894736 3.685 AP2M1
adaptor-related protein complex 2, mu 1 subunit
chrX_-_13835012 3.683 GPM6B
glycoprotein M6B
chr17_+_70117177 3.675 SOX9
SRY (sex determining region Y)-box 9
chr18_+_2571509 3.674 NM_006101
NDC80
NDC80 kinetochore complex component homolog (S. cerevisiae)
chrX_-_10588458 3.627 NM_000381
NM_033289
MID1

midline 1 (Opitz/BBB syndrome)

chr5_+_140864626 3.608 NM_018928
NM_032406
PCDHGC4

protocadherin gamma subfamily C, 4

chr1_-_59042827 3.607 TACSTD2
tumor-associated calcium signal transducer 2
chrX_+_153657119 3.603 ATP6AP1
ATPase, H+ transporting, lysosomal accessory protein 1
chr2_-_47168870 3.582 MCFD2
multiple coagulation factor deficiency 2
chr16_+_2563914 3.578 ATP6V0C
ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
chr12_+_53491417 3.564 NM_002178
IGFBP6
insulin-like growth factor binding protein 6
chr1_-_23885916 3.555 ID3
inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
chr6_-_112575880 3.541 LAMA4
laminin, alpha 4
chr1_+_65613971 3.540 AK4
adenylate kinase 4
chr15_-_72522062 3.533 NM_001206799
PKM2
pyruvate kinase, muscle
chr11_-_67450536 3.530 RPL37
ribosomal protein L37
chr7_+_872137 3.509 NM_001130965
SUN1
Sad1 and UNC84 domain containing 1
chr16_-_47005339 3.507 DNAJA2
DnaJ (Hsp40) homolog, subfamily A, member 2
chr16_+_82660390 3.504 NM_001220488
NM_001220489
NM_001220490
NM_001220491
NM_001220492
NM_001257
CDH13





cadherin 13, H-cadherin (heart)





chr7_+_107221203 3.499 NM_001008405
BCAP29
B-cell receptor-associated protein 29
chr3_-_149095413 3.492 TM4SF1
transmembrane 4 L six family member 1
chr14_+_29236882 3.491 FOXG1
forkhead box G1
chr12_-_90049818 3.490 NM_001001323
NM_001682
ATP2B1

ATPase, Ca++ transporting, plasma membrane 1

chr1_+_51701943 3.480 NM_014372
RNF11
ring finger protein 11
chrX_+_47078053 3.477 NM_006201
CDK16
cyclin-dependent kinase 16
chr17_-_76989770 3.477 CANT1
calcium activated nucleotidase 1
chr15_+_74218786 3.472 NM_005576
LOXL1
lysyl oxidase-like 1
chr1_-_217250230 3.460 NM_001243507
NM_001243509
ESRRG

estrogen-related receptor gamma

chr17_+_38137088 3.457 PSMD3
proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
chr11_-_8832189 3.452 NM_213618
ST5
suppression of tumorigenicity 5
chr12_-_53343607 3.444 KRT8
keratin 8
chr18_+_2571587 3.434 NDC80
NDC80 kinetochore complex component homolog (S. cerevisiae)
chr9_-_14313509 3.433 NFIB
nuclear factor I/B
chr20_+_9458460 3.416 PLCB4
phospholipase C, beta 4
chr11_-_31832855 3.413 NM_000280
NM_001604
PAX6

paired box 6

chr6_-_110501164 3.408 NM_001024934
NM_001024935
NM_001024936
NM_003931
WASF1



WAS protein family, member 1



chr15_+_74218794 3.400 LOXL1
lysyl oxidase-like 1
chr17_+_70117168 3.397 SOX9
SRY (sex determining region Y)-box 9
chr16_-_87903028 3.395 NM_003486
SLC7A5
solute carrier family 7 (amino acid transporter light chain, L system), member 5
chr11_-_33744497 3.394 NM_001127227
CD59
CD59 molecule, complement regulatory protein
chr5_+_137514753 3.384 KIF20A
kinesin family member 20A
chr19_+_3094528 3.383 GNA11
guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
chr7_-_6523689 3.375 NM_001100603
NM_006854
KDELR2

KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.21 6.84e-40 GO:0009987 cellular process
1.46 7.45e-18 GO:0048731 system development
1.22 1.22e-17 GO:0065007 biological regulation
1.42 9.40e-17 GO:0048856 anatomical structure development
1.35 5.37e-14 GO:0032502 developmental process
1.49 1.04e-13 GO:0065008 regulation of biological quality
1.47 1.27e-13 GO:0042221 response to chemical stimulus
1.36 1.53e-13 GO:0007275 multicellular organismal development
1.42 3.59e-13 GO:0048518 positive regulation of biological process
1.44 5.43e-13 GO:0048522 positive regulation of cellular process
1.44 1.32e-12 GO:0048519 negative regulation of biological process
1.22 5.00e-12 GO:0044237 cellular metabolic process
1.56 1.20e-11 GO:0007399 nervous system development
1.19 1.49e-11 GO:0050789 regulation of biological process
1.45 1.52e-11 GO:0048523 negative regulation of cellular process
1.20 1.94e-11 GO:0008152 metabolic process
1.33 3.45e-11 GO:0071840 cellular component organization or biogenesis
1.20 4.17e-11 GO:0050794 regulation of cellular process
1.22 4.99e-11 GO:0050896 response to stimulus
1.33 5.80e-11 GO:0016043 cellular component organization
1.54 1.35e-10 GO:0009653 anatomical structure morphogenesis
1.27 2.04e-09 GO:0051716 cellular response to stimulus
1.29 2.42e-09 GO:0023052 signaling
1.23 5.67e-09 GO:0032501 multicellular organismal process
1.37 8.41e-09 GO:0006950 response to stress
2.18 1.45e-08 GO:0016337 cell-cell adhesion
1.34 1.55e-08 GO:0071841 cellular component organization or biogenesis at cellular level
1.71 1.74e-08 GO:0007155 cell adhesion
1.71 1.74e-08 GO:0022610 biological adhesion
1.29 4.18e-08 GO:0051179 localization
2.75 5.37e-08 GO:0007156 homophilic cell adhesion
1.34 5.41e-08 GO:0071842 cellular component organization at cellular level
1.31 9.73e-08 GO:0051234 establishment of localization
1.56 1.04e-07 GO:0051246 regulation of protein metabolic process
1.61 1.07e-07 GO:0048468 cell development
1.39 1.16e-07 GO:0030154 cell differentiation
1.18 1.46e-07 GO:0044238 primary metabolic process
1.51 1.47e-07 GO:0009893 positive regulation of metabolic process
1.31 2.15e-07 GO:0006810 transport
1.53 2.29e-07 GO:0010604 positive regulation of macromolecule metabolic process
1.57 2.30e-07 GO:0032268 regulation of cellular protein metabolic process
1.51 3.78e-07 GO:0031325 positive regulation of cellular metabolic process
1.37 6.35e-07 GO:0048869 cellular developmental process
1.27 9.10e-07 GO:0007165 signal transduction
1.83 1.27e-06 GO:0072358 cardiovascular system development
1.83 1.27e-06 GO:0072359 circulatory system development
1.27 2.18e-06 GO:0006807 nitrogen compound metabolic process
1.47 2.20e-06 GO:0010033 response to organic substance
1.44 3.21e-06 GO:0009966 regulation of signal transduction
1.40 4.94e-06 GO:0023051 regulation of signaling
1.60 6.03e-06 GO:0031399 regulation of protein modification process
1.55 6.24e-06 GO:0022008 neurogenesis
1.85 7.08e-06 GO:0051247 positive regulation of protein metabolic process
1.27 8.13e-06 GO:0034641 cellular nitrogen compound metabolic process
1.67 1.17e-05 GO:0051726 regulation of cell cycle
1.86 1.41e-05 GO:0032270 positive regulation of cellular protein metabolic process
1.54 1.76e-05 GO:0009611 response to wounding
1.55 1.80e-05 GO:0008219 cell death
1.74 2.39e-05 GO:0000904 cell morphogenesis involved in differentiation
1.59 2.61e-05 GO:0007267 cell-cell signaling
1.54 2.61e-05 GO:0016265 death
1.50 2.63e-05 GO:0007154 cell communication
1.48 3.08e-05 GO:0010646 regulation of cell communication
1.36 3.53e-05 GO:0044281 small molecule metabolic process
1.68 3.55e-05 GO:0048666 neuron development
1.29 3.66e-05 GO:0009058 biosynthetic process
2.64 3.91e-05 GO:0090068 positive regulation of cell cycle process
1.35 4.18e-05 GO:0048513 organ development
1.60 5.42e-05 GO:0030182 neuron differentiation
1.58 5.68e-05 GO:0071844 cellular component assembly at cellular level
1.65 5.87e-05 GO:0042060 wound healing
1.99 6.59e-05 GO:0007346 regulation of mitotic cell cycle
1.34 7.55e-05 GO:0048583 regulation of response to stimulus
1.91 8.23e-05 GO:0031401 positive regulation of protein modification process
1.27 9.64e-05 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.41 1.04e-04 GO:0033036 macromolecule localization
4.69 1.13e-04 GO:0016339 calcium-dependent cell-cell adhesion
1.52 1.15e-04 GO:0048699 generation of neurons
1.58 1.32e-04 GO:0009790 embryo development
1.44 1.44e-04 GO:0044248 cellular catabolic process
1.53 1.57e-04 GO:0051128 regulation of cellular component organization
1.61 1.65e-04 GO:0032989 cellular component morphogenesis
1.64 1.78e-04 GO:0050878 regulation of body fluid levels
1.69 2.06e-04 GO:0031175 neuron projection development
1.73 2.69e-04 GO:0048667 cell morphogenesis involved in neuron differentiation
1.90 3.18e-04 GO:0001944 vasculature development
1.38 3.68e-04 GO:0009056 catabolic process
1.83 3.77e-04 GO:0007411 axon guidance
1.46 3.90e-04 GO:0009892 negative regulation of metabolic process
1.50 3.98e-04 GO:0040011 locomotion
1.65 4.15e-04 GO:0044265 cellular macromolecule catabolic process
1.93 4.55e-04 GO:0001568 blood vessel development
1.45 4.68e-04 GO:0042981 regulation of apoptosis
1.76 5.06e-04 GO:0006163 purine nucleotide metabolic process
1.28 5.52e-04 GO:0044249 cellular biosynthetic process
1.54 5.56e-04 GO:0012501 programmed cell death
1.45 5.79e-04 GO:0009605 response to external stimulus
1.48 6.14e-04 GO:0031324 negative regulation of cellular metabolic process
1.70 6.29e-04 GO:0048812 neuron projection morphogenesis
1.44 6.57e-04 GO:0022607 cellular component assembly
1.41 6.70e-04 GO:0044085 cellular component biogenesis
1.57 8.15e-04 GO:0001932 regulation of protein phosphorylation
1.43 8.58e-04 GO:0043067 regulation of programmed cell death
1.55 9.03e-04 GO:0042325 regulation of phosphorylation
1.70 9.11e-04 GO:0072521 purine-containing compound metabolic process
1.64 9.17e-04 GO:0006935 chemotaxis
1.64 9.17e-04 GO:0042330 taxis
1.54 9.82e-04 GO:0043085 positive regulation of catalytic activity
1.43 1.03e-03 GO:0010941 regulation of cell death
1.64 1.10e-03 GO:0044283 small molecule biosynthetic process
1.53 1.17e-03 GO:0006915 apoptosis
1.49 1.21e-03 GO:0044093 positive regulation of molecular function
1.84 1.21e-03 GO:0009144 purine nucleoside triphosphate metabolic process
1.82 1.51e-03 GO:0009141 nucleoside triphosphate metabolic process
1.53 1.56e-03 GO:0019220 regulation of phosphate metabolic process
1.53 1.56e-03 GO:0051174 regulation of phosphorus metabolic process
1.76 1.57e-03 GO:0010564 regulation of cell cycle process
1.99 1.58e-03 GO:0048514 blood vessel morphogenesis
1.83 1.72e-03 GO:0009205 purine ribonucleoside triphosphate metabolic process
2.79 1.82e-03 GO:0051352 negative regulation of ligase activity
2.79 1.82e-03 GO:0051444 negative regulation of ubiquitin-protein ligase activity
1.78 1.96e-03 GO:0009259 ribonucleotide metabolic process
1.79 1.99e-03 GO:0009150 purine ribonucleotide metabolic process
1.83 1.99e-03 GO:0009199 ribonucleoside triphosphate metabolic process
1.53 2.29e-03 GO:0009719 response to endogenous stimulus
2.80 2.72e-03 GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
1.68 3.00e-03 GO:0007409 axonogenesis
1.62 3.09e-03 GO:0048585 negative regulation of response to stimulus
1.34 3.11e-03 GO:0065009 regulation of molecular function
1.44 3.33e-03 GO:0010605 negative regulation of macromolecule metabolic process
1.95 3.78e-03 GO:0000075 cell cycle checkpoint
1.55 4.09e-03 GO:0009725 response to hormone stimulus
2.95 4.52e-03 GO:0042058 regulation of epidermal growth factor receptor signaling pathway
2.16 5.08e-03 GO:0000082 G1/S transition of mitotic cell cycle
1.36 5.71e-03 GO:0051641 cellular localization
1.54 5.96e-03 GO:0000902 cell morphogenesis
1.66 6.13e-03 GO:0009968 negative regulation of signal transduction
2.33 6.26e-03 GO:0000077 DNA damage checkpoint
1.82 6.45e-03 GO:0015980 energy derivation by oxidation of organic compounds
1.67 7.29e-03 GO:0006091 generation of precursor metabolites and energy
1.53 7.74e-03 GO:0009057 macromolecule catabolic process
1.84 7.88e-03 GO:0008361 regulation of cell size
2.31 7.90e-03 GO:0042770 signal transduction in response to DNA damage
1.42 8.34e-03 GO:0070887 cellular response to chemical stimulus
1.37 9.46e-03 GO:0050790 regulation of catalytic activity
1.55 9.55e-03 GO:0055086 nucleobase, nucleoside and nucleotide metabolic process
1.38 9.67e-03 GO:0051649 establishment of localization in cell
1.51 9.81e-03 GO:0007167 enzyme linked receptor protein signaling pathway
2.29 9.93e-03 GO:0031398 positive regulation of protein ubiquitination
1.59 1.02e-02 GO:0007596 blood coagulation
1.59 1.02e-02 GO:0050817 coagulation
1.58 1.03e-02 GO:0006753 nucleoside phosphate metabolic process
1.58 1.03e-02 GO:0009117 nucleotide metabolic process
2.26 1.04e-02 GO:0031570 DNA integrity checkpoint
1.42 1.27e-02 GO:0042592 homeostatic process
1.88 1.32e-02 GO:0071156 regulation of cell cycle arrest
1.44 1.36e-02 GO:0033554 cellular response to stress
1.58 1.37e-02 GO:0007599 hemostasis
1.55 1.39e-02 GO:0019725 cellular homeostasis
2.65 1.42e-02 GO:0031571 mitotic cell cycle G1/S transition DNA damage checkpoint
2.44 1.43e-02 GO:0030330 DNA damage response, signal transduction by p53 class mediator
3.52 1.70e-02 GO:0007416 synapse assembly
1.38 1.73e-02 GO:0008104 protein localization
1.44 1.82e-02 GO:0046907 intracellular transport
2.41 1.84e-02 GO:0031397 negative regulation of protein ubiquitination
1.49 1.91e-02 GO:0046483 heterocycle metabolic process
2.07 1.98e-02 GO:0034330 cell junction organization
1.66 1.98e-02 GO:0009792 embryo development ending in birth or egg hatching
1.77 2.04e-02 GO:0061061 muscle structure development
1.50 2.06e-02 GO:0048878 chemical homeostasis
1.34 2.11e-02 GO:0051239 regulation of multicellular organismal process
1.60 2.11e-02 GO:0023057 negative regulation of signaling
1.64 2.11e-02 GO:0006886 intracellular protein transport
3.07 2.13e-02 GO:0042773 ATP synthesis coupled electron transport
3.07 2.13e-02 GO:0042775 mitochondrial ATP synthesis coupled electron transport
2.53 2.22e-02 GO:0045787 positive regulation of cell cycle
1.60 2.33e-02 GO:0010648 negative regulation of cell communication
2.70 2.39e-02 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
2.70 2.39e-02 GO:0072395 signal transduction involved in cell cycle checkpoint
2.70 2.39e-02 GO:0072401 signal transduction involved in DNA integrity checkpoint
2.70 2.39e-02 GO:0072404 signal transduction involved in G1/S transition checkpoint
2.70 2.39e-02 GO:0072413 signal transduction involved in mitotic cell cycle checkpoint
2.70 2.39e-02 GO:0072422 signal transduction involved in DNA damage checkpoint
2.70 2.39e-02 GO:0072431 signal transduction involved in mitotic cell cycle G1/S transition DNA damage checkpoint
2.70 2.39e-02 GO:0072474 signal transduction involved in mitotic cell cycle G1/S checkpoint
2.15 2.45e-02 GO:0045333 cellular respiration
1.70 2.69e-02 GO:0006511 ubiquitin-dependent protein catabolic process
1.81 2.76e-02 GO:0032269 negative regulation of cellular protein metabolic process
1.69 2.78e-02 GO:0019941 modification-dependent protein catabolic process
1.58 2.88e-02 GO:0008283 cell proliferation
1.15 2.88e-02 GO:0043170 macromolecule metabolic process
1.56 2.95e-02 GO:0019226 transmission of nerve impulse
1.56 2.95e-02 GO:0035637 multicellular organismal signaling
1.55 2.95e-02 GO:0032990 cell part morphogenesis
1.48 3.07e-02 GO:0030030 cell projection organization
1.60 3.10e-02 GO:0006873 cellular ion homeostasis
2.00 3.22e-02 GO:0010498 proteasomal protein catabolic process
2.00 3.22e-02 GO:0043161 proteasomal ubiquitin-dependent protein catabolic process
2.54 3.35e-02 GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
1.81 3.39e-02 GO:0001558 regulation of cell growth
2.03 3.42e-02 GO:0043062 extracellular structure organization
1.68 3.52e-02 GO:0043632 modification-dependent macromolecule catabolic process
1.67 3.63e-02 GO:0051603 proteolysis involved in cellular protein catabolic process
3.50 3.78e-02 GO:0060338 regulation of type I interferon-mediated signaling pathway
1.98 3.82e-02 GO:0031400 negative regulation of protein modification process
1.54 3.88e-02 GO:0034613 cellular protein localization
1.49 3.89e-02 GO:0009887 organ morphogenesis
1.57 4.24e-02 GO:0016044 cellular membrane organization
1.58 4.63e-02 GO:0007268 synaptic transmission
1.53 4.63e-02 GO:0044092 negative regulation of molecular function
1.92 4.65e-02 GO:0003012 muscle system process
2.44 4.91e-02 GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.27 2.23e-33 GO:0005737 cytoplasm
1.31 3.20e-25 GO:0044444 cytoplasmic part
1.13 1.39e-15 GO:0044424 intracellular part
1.12 1.96e-13 GO:0005622 intracellular
1.21 4.29e-10 GO:0044422 organelle part
1.38 1.97e-09 GO:0044459 plasma membrane part
1.20 1.01e-08 GO:0044446 intracellular organelle part
1.63 1.23e-08 GO:0005626 insoluble fraction
1.53 2.67e-08 GO:0000267 cell fraction
1.67 4.01e-08 GO:0016023 cytoplasmic membrane-bounded vesicle
1.66 4.69e-08 GO:0031988 membrane-bounded vesicle
1.64 5.16e-08 GO:0031410 cytoplasmic vesicle
1.62 6.96e-08 GO:0005624 membrane fraction
1.12 7.89e-08 GO:0043229 intracellular organelle
1.12 8.14e-08 GO:0043226 organelle
1.29 1.10e-07 GO:0043234 protein complex
1.61 1.90e-07 GO:0031982 vesicle
1.69 4.74e-07 GO:0030054 cell junction
1.12 1.19e-06 GO:0043231 intracellular membrane-bounded organelle
1.12 1.26e-06 GO:0043227 membrane-bounded organelle
1.24 2.04e-06 GO:0032991 macromolecular complex
1.21 8.69e-06 GO:0071944 cell periphery
1.76 2.09e-05 GO:0045202 synapse
1.20 2.10e-05 GO:0005886 plasma membrane
1.76 2.25e-05 GO:0043005 neuron projection
1.31 2.31e-05 GO:0005829 cytosol
1.30 2.74e-05 GO:0031090 organelle membrane
2.70 3.38e-05 GO:0042470 melanosome
2.70 3.38e-05 GO:0048770 pigment granule
2.13 6.11e-05 GO:0030424 axon
1.38 6.22e-05 GO:0005739 mitochondrion
1.04 6.34e-05 GO:0044464 cell part
1.04 6.63e-05 GO:0005623 cell
2.98 1.05e-04 GO:0000502 proteasome complex
1.52 3.11e-04 GO:0044429 mitochondrial part
1.64 5.30e-04 GO:0031966 mitochondrial membrane
1.11 7.96e-04 GO:0016020 membrane
1.43 1.04e-03 GO:0042995 cell projection
2.26 1.06e-03 GO:0030016 myofibril
1.60 1.14e-03 GO:0005740 mitochondrial envelope
1.45 1.23e-03 GO:0005615 extracellular space
2.20 1.68e-03 GO:0043292 contractile fiber
2.00 2.24e-03 GO:0070161 anchoring junction
3.52 2.60e-03 GO:0005913 cell-cell adherens junction
1.36 4.85e-03 GO:0044421 extracellular region part
1.70 5.48e-03 GO:0015629 actin cytoskeleton
1.84 1.03e-02 GO:0005911 cell-cell junction
1.31 1.11e-02 GO:0005887 integral to plasma membrane
2.12 1.23e-02 GO:0044449 contractile fiber part
1.96 1.24e-02 GO:0005912 adherens junction
1.33 1.49e-02 GO:0005783 endoplasmic reticulum
1.20 1.62e-02 GO:0043228 non-membrane-bounded organelle
1.20 1.62e-02 GO:0043232 intracellular non-membrane-bounded organelle
1.62 1.70e-02 GO:0019866 organelle inner membrane
1.30 1.78e-02 GO:0031226 intrinsic to plasma membrane
1.64 2.16e-02 GO:0005743 mitochondrial inner membrane
1.21 2.54e-02 GO:0031974 membrane-enclosed lumen
1.26 3.10e-02 GO:0005856 cytoskeleton
2.14 3.30e-02 GO:0030017 sarcomere
1.80 3.37e-02 GO:0030425 dendrite
1.39 4.03e-02 GO:0031975 envelope
1.59 4.55e-02 GO:0044433 cytoplasmic vesicle part
1.61 4.81e-02 GO:0044456 synapse part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.29 4.63e-31 GO:0005515 protein binding
1.13 1.29e-18 GO:0005488 binding
1.90 1.48e-04 GO:0032403 protein complex binding
1.43 2.34e-04 GO:0005102 receptor binding
1.50 2.58e-04 GO:0042802 identical protein binding
1.53 4.51e-04 GO:0005509 calcium ion binding
1.56 1.58e-03 GO:0008092 cytoskeletal protein binding
1.44 5.68e-03 GO:0019899 enzyme binding
1.88 1.85e-02 GO:0005126 cytokine receptor binding
1.82 2.90e-02 GO:0005125 cytokine activity
1.89 4.51e-02 GO:0008083 growth factor activity