Motif ID: NFE2L2.p2

Z-value: 1.958


Transcription factors associated with NFE2L2.p2:

Gene SymbolEntrez IDGene Name
NFE2L2 4780 nuclear factor (erythroid-derived 2)-like 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NFE2L2chr2_-_1781285270.243.8e-04Click!


Activity profile for motif NFE2L2.p2.

activity profile for motif NFE2L2.p2


Sorted Z-values histogram for motif NFE2L2.p2

Sorted Z-values for motif NFE2L2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFE2L2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_+_30771520 86.684 PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr17_+_30771494 61.924 NM_002815
PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr17_+_30771522 61.634 PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr17_+_30771485 61.267 PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr14_+_58711555 55.692 PSMA3
proteasome (prosome, macropain) subunit, alpha type, 3
chr17_+_30771532 55.319 PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr17_-_73150769 54.957 NM_001002032
NM_001002033
NM_016185
HN1


hematological and neurological expressed 1


chr14_+_58711457 52.658 NM_002788
NM_152132
PSMA3

proteasome (prosome, macropain) subunit, alpha type, 3

chr14_+_58711599 52.609 PSMA3
proteasome (prosome, macropain) subunit, alpha type, 3
chr2_+_162164785 52.428 NM_005805
PSMD14
proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
chr1_-_225616556 51.543 NM_194442
LBR
lamin B receptor
chr18_+_158586 47.360 USP14
ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
chr18_+_158480 46.167 NM_001037334
NM_005151
USP14

ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)

chr16_+_30077120 44.925 ALDOA
aldolase A, fructose-bisphosphate
chr16_+_30076993 44.558 NM_001243177
NM_184041
ALDOA

aldolase A, fructose-bisphosphate

chr16_+_30077146 44.096 ALDOA
aldolase A, fructose-bisphosphate
chr6_-_31704304 43.495 CLIC1
chloride intracellular channel 1
chr2_+_231921625 43.218 PSMD1
proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
chr6_-_31704281 42.592 CLIC1
chloride intracellular channel 1
chr6_-_31704272 42.391 CLIC1
chloride intracellular channel 1
chr6_-_31704287 42.340 CLIC1
chloride intracellular channel 1
chr11_-_14541867 41.955 PSMA1
proteasome (prosome, macropain) subunit, alpha type, 1
chr1_-_109969058 41.645 NM_001199772
NM_002790
NM_001199773
NM_001199774
PSMA5



proteasome (prosome, macropain) subunit, alpha type, 5



chr6_-_31704318 41.427 NM_001288
CLIC1
chloride intracellular channel 1
chr7_-_96339074 39.670 SHFM1
split hand/foot malformation (ectrodactyly) type 1
chr1_-_45987548 38.278 NM_002574
NM_181696
NM_181697
PRDX1


peroxiredoxin 1


chr2_+_162164993 38.264 PSMD14
proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
chrX_+_119738542 38.178 NM_001137554
MCTS1
malignant T cell amplified sequence 1
chr11_-_14541886 38.151 NM_001143937
NM_002786
PSMA1

proteasome (prosome, macropain) subunit, alpha type, 1

chr17_-_65362635 38.127 PSMD12
proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
chr1_-_109969044 37.524 PSMA5
proteasome (prosome, macropain) subunit, alpha type, 5
chr10_+_85899184 34.653 NM_014394
GHITM
growth hormone inducible transmembrane protein
chrX_-_109683457 34.174 NM_001171689
AMMECR1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr1_-_94374949 33.334 GCLM
glutamate-cysteine ligase, modifier subunit
chr16_+_74330660 33.291 NM_002811
PSMD7
proteasome (prosome, macropain) 26S subunit, non-ATPase, 7
chr1_-_94374986 33.145 NM_002061
GCLM
glutamate-cysteine ligase, modifier subunit
chr6_+_34206567 33.125 NM_145905
HMGA1
high mobility group AT-hook 1
chr6_-_31704093 32.770 CLIC1
chloride intracellular channel 1
chr11_+_118958696 32.633 NM_001024382
HMBS
hydroxymethylbilane synthase
chr16_-_69760444 32.274 NM_000903
NM_001025433
NM_001025434
NQO1


NAD(P)H dehydrogenase, quinone 1


chr1_-_94375028 30.098 GCLM
glutamate-cysteine ligase, modifier subunit
chr22_+_23010757 30.070


chr1_-_109968951 29.314 PSMA5
proteasome (prosome, macropain) subunit, alpha type, 5
chr5_+_159436143 27.803 TTC1
tetratricopeptide repeat domain 1
chr11_-_47447457 27.132 PSMC3
proteasome (prosome, macropain) 26S subunit, ATPase, 3
chr12_-_76478347 26.530 NAP1L1
nucleosome assembly protein 1-like 1
chr2_-_32236104 26.016 MEMO1
mediator of cell motility 1
chr1_+_223889253 25.669 NM_001146068
CAPN2
calpain 2, (m/II) large subunit
chr11_-_47447779 25.012 PSMC3
proteasome (prosome, macropain) 26S subunit, ATPase, 3
chr17_-_79881304 24.994 NM_032711
MAFG
v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian)
chr21_+_33031932 24.911 NM_000454
SOD1
superoxide dismutase 1, soluble
chr9_-_113018869 24.590 NM_001244938
NM_003329
TXN

thioredoxin

chr6_-_31704070 24.179 CLIC1
chloride intracellular channel 1
chr7_-_96339171 24.092 NM_006304
SHFM1
split hand/foot malformation (ectrodactyly) type 1
chr7_+_112063131 23.776 NM_001007245
NM_001197080
IFRD1

interferon-related developmental regulator 1

chr2_+_231921608 23.213 PSMD1
proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
chr1_-_246580710 23.146 NM_022743
SMYD3
SET and MYND domain containing 3
chr6_+_44195008 22.882 SLC29A1
solute carrier family 29 (nucleoside transporters), member 1
chr5_+_10353980 22.851


chr18_-_54305657 22.800 TXNL1
thioredoxin-like 1
chr10_+_131934674 22.671 GLRX3
glutaredoxin 3
chr17_-_65362667 22.408 NM_002816
NM_174871
PSMD12

proteasome (prosome, macropain) 26S subunit, non-ATPase, 12

chr3_+_184038050 22.391 NM_004953
EIF4G1
eukaryotic translation initiation factor 4 gamma, 1
chr5_-_137911039 22.371 HSPA9
heat shock 70kDa protein 9 (mortalin)
chr17_+_30677178 21.684 ZNF207
zinc finger protein 207
chr5_-_137911005 21.657 HSPA9
heat shock 70kDa protein 9 (mortalin)
chr3_+_183894736 21.544 AP2M1
adaptor-related protein complex 2, mu 1 subunit
chr22_-_19466725 20.949 NM_001035247
NM_005659
UFD1L

ubiquitin fusion degradation 1 like (yeast)

chr3_+_141043054 20.847 NM_001080412
ZBTB38
zinc finger and BTB domain containing 38
chr19_+_38865184 20.809 NM_002812
PSMD8
proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
chr7_-_134854225 20.524 NM_001243753
NM_001243755
C7orf49

chromosome 7 open reading frame 49

chr11_-_47447915 20.357 NM_002804
PSMC3
proteasome (prosome, macropain) 26S subunit, ATPase, 3
chr17_+_30677138 20.166 NM_001032293
NM_001098507
NM_003457
ZNF207


zinc finger protein 207


chr19_+_36630999 19.701 CAPNS1
calpain, small subunit 1
chr3_+_184038445 19.636 EIF4G1
eukaryotic translation initiation factor 4 gamma, 1
chr19_+_36630846 19.627 NM_001003962
NM_001749
CAPNS1

calpain, small subunit 1

chr12_-_76478737 19.431 NM_004537
NM_139207
NAP1L1

nucleosome assembly protein 1-like 1

chr6_-_170862326 18.618 PSMB1
proteasome (prosome, macropain) subunit, beta type, 1
chr19_+_36631001 18.487 CAPNS1
calpain, small subunit 1
chr22_-_19466621 18.451 UFD1L
ubiquitin fusion degradation 1 like (yeast)
chr17_+_30677187 18.189 ZNF207
zinc finger protein 207
chr6_+_150070856 18.167 PCMT1
protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr7_-_102985068 18.149 NM_001129887
NM_014377
DNAJC2

DnaJ (Hsp40) homolog, subfamily C, member 2

chr1_-_150208441 17.954 ANP32E
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr1_-_6445737 17.882 NM_181864
ACOT7
acyl-CoA thioesterase 7
chr6_-_35888816 17.650 SRPK1
SRSF protein kinase 1
chr4_+_39699663 17.601 NM_001111112
NM_001111113
NM_005339
UBE2K


ubiquitin-conjugating enzyme E2K


chr3_+_184016985 17.563 NM_002808
PSMD2
proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
chr12_-_76478410 17.409 NAP1L1
nucleosome assembly protein 1-like 1
chr11_-_16996559 17.157 RPL36A
ribosomal protein L36a
chr20_+_44637539 17.105 NM_004994
MMP9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
chr17_+_79650961 16.707 NM_004712
HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chr5_-_95158465 16.682 NM_001118890
NM_001243658
NM_001243659
NM_002064
GLRX



glutaredoxin (thioltransferase)



chr1_-_150208462 16.672 NM_001136478
NM_030920
ANP32E

acidic (leucine-rich) nuclear phosphoprotein 32 family, member E

chr1_+_110546569 16.571 NM_001242675
NM_001242676
AHCYL1

adenosylhomocysteinase-like 1

chr6_-_24719286 16.435 NM_030939
C6orf62
chromosome 6 open reading frame 62
chr5_-_150727088 16.429 NM_181776
SLC36A2
solute carrier family 36 (proton/amino acid symporter), member 2
chr19_-_2038937 16.382 MKNK2
MAP kinase interacting serine/threonine kinase 2
chr12_-_53343607 16.184 KRT8
keratin 8
chr17_+_75372164 16.181 NM_001113494
SEPT9
septin 9
chr14_+_103800678 16.036 EIF5
eukaryotic translation initiation factor 5
chr17_+_79651042 16.022 HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chr12_+_64798050 15.708 NM_007235
XPOT
exportin, tRNA (nuclear export receptor for tRNAs)
chrX_-_15511710 15.674 NM_001018109
NM_003662
PIR

pirin (iron-binding nuclear protein)

chr17_+_79651035 15.584 HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chr1_-_154943001 15.558 NM_001130040
NM_183001
SHC1

SHC (Src homology 2 domain containing) transforming protein 1

chr15_+_89182038 15.526 NM_002201
ISG20
interferon stimulated exonuclease gene 20kDa
chr17_+_28707495 15.085 NM_001199775
CPD
carboxypeptidase D
chr3_-_128902672 15.041 CNBP
CCHC-type zinc finger, nucleic acid binding protein
chrX_-_15511358 14.999 PIR
pirin (iron-binding nuclear protein)
chr16_+_74330730 14.982 PSMD7
proteasome (prosome, macropain) 26S subunit, non-ATPase, 7
chr5_-_95158365 14.950 GLRX
glutaredoxin (thioltransferase)
chr13_+_29233279 14.906 POMP
proteasome maturation protein
chr3_+_184017038 14.863 PSMD2
proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
chr12_-_57030083 14.642 NM_013449
BAZ2A
bromodomain adjacent to zinc finger domain, 2A
chr3_-_128902764 14.588 NM_001127192
NM_001127193
NM_001127194
NM_001127195
NM_001127196
NM_003418
CNBP





CCHC-type zinc finger, nucleic acid binding protein





chr13_+_29233140 14.573 NM_015932
POMP
proteasome maturation protein
chr7_+_130794854 14.511 NM_001145354
MKLN1
muskelin 1, intracellular mediator containing kelch motifs
chr6_-_35888937 14.468 NM_003137
SRPK1
SRSF protein kinase 1
chr8_-_59572403 14.454 NM_003580
NSMAF
neutral sphingomyelinase (N-SMase) activation associated factor
chr22_+_45072687 14.402 NM_001017530
NM_001198721
NM_015366
PRR5


proline rich 5 (renal)


chr18_-_54305839 14.400 NM_004786
TXNL1
thioredoxin-like 1
chr6_+_150070818 14.071 NM_001252049
NM_001252050
NM_001252051
NM_001252052
NM_001252053
NM_005389
PCMT1





protein-L-isoaspartate (D-aspartate) O-methyltransferase





chr8_-_59572385 13.931 NSMAF
neutral sphingomyelinase (N-SMase) activation associated factor
chr9_+_140135698 13.895 NM_006088
TUBB4B
tubulin, beta 4B class IVb
chr22_-_45608232 13.779 KIAA0930
KIAA0930
chr16_+_89988416 13.652 NM_001197181
TUBB3
tubulin, beta 3 class III
chr7_+_148395886 13.579 NM_003592
CUL1
cullin 1
chr6_-_24877453 13.379 NM_015864
FAM65B
family with sequence similarity 65, member B
chr19_+_34855594 13.378 NM_001184722
NM_000175
GPI

glucose-6-phosphate isomerase

chr2_+_231921595 13.352 PSMD1
proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
chr9_+_140135738 13.201 TUBB4B
tubulin, beta 4B class IVb
chr9_-_113018711 13.150 TXN
thioredoxin
chr6_-_84140744 12.969 ME1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr21_-_46237882 12.959 SUMO3
SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae)
chr11_+_62649160 12.947 SLC3A2
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
chr5_+_159436155 12.760 NM_003314
TTC1
tetratricopeptide repeat domain 1
chr9_+_130922471 12.736 NM_024112
C9orf16
chromosome 9 open reading frame 16
chr8_-_59571920 12.644 NM_001144772
NSMAF
neutral sphingomyelinase (N-SMase) activation associated factor
chr7_+_148396016 12.490 CUL1
cullin 1
chr6_+_44214853 12.444 HSP90AB1
heat shock protein 90kDa alpha (cytosolic), class B member 1
chr22_+_45072936 12.383 PRR5
proline rich 5 (renal)
chr19_+_34856155 12.357 GPI
glucose-6-phosphate isomerase
chr17_+_18625335 12.113 NM_001037330
TRIM16L
tripartite motif containing 16-like
chr17_+_61905043 12.043 NM_001199163
PSMC5
proteasome (prosome, macropain) 26S subunit, ATPase, 5
chr21_-_46237966 11.991 SUMO3
SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae)
chr2_+_231921562 11.885 NM_001191037
NM_002807
PSMD1

proteasome (prosome, macropain) 26S subunit, non-ATPase, 1

chr1_-_33366838 11.880 NM_033504
TMEM54
transmembrane protein 54
chr6_+_44214786 11.770 NM_007355
HSP90AB1
heat shock protein 90kDa alpha (cytosolic), class B member 1
chr1_-_150208134 11.729 ANP32E
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr17_-_28618836 11.676 BLMH
bleomycin hydrolase
chr10_+_121411086 11.641 BAG3
BCL2-associated athanogene 3
chr20_+_55043682 11.582 C20orf43
chromosome 20 open reading frame 43
chr19_+_34856123 11.538 GPI
glucose-6-phosphate isomerase
chr7_-_42971730 11.279 PSMA2
proteasome (prosome, macropain) subunit, alpha type, 2
chr17_-_61905030 11.248 NM_017647
FTSJ3
FtsJ homolog 3 (E. coli)
chr6_+_150070844 11.178 PCMT1
protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr1_+_40506254 11.142 NM_001105530
NM_006367
CAP1

CAP, adenylate cyclase-associated protein 1 (yeast)

chr21_-_33651324 11.013 NM_018944
MIS18A
MIS18 kinetochore protein homolog A (S. pombe)
chr9_-_113018802 10.923 TXN
thioredoxin
chr12_+_64803741 10.912 XPOT
exportin, tRNA (nuclear export receptor for tRNAs)
chr6_-_84140758 10.842 ME1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr8_-_59572188 10.770 NSMAF
neutral sphingomyelinase (N-SMase) activation associated factor
chr2_-_32236053 10.710 MEMO1
mediator of cell motility 1
chr10_-_75173789 10.629 ANXA7
annexin A7
chr7_+_148395995 10.447 CUL1
cullin 1
chr17_-_28619183 10.337 NM_000386
BLMH
bleomycin hydrolase
chr1_+_40506423 10.326 CAP1
CAP, adenylate cyclase-associated protein 1 (yeast)
chr16_+_22308722 10.320 NM_018119
POLR3E
polymerase (RNA) III (DNA directed) polypeptide E (80kD)
chr1_-_52344377 10.293 NRD1
nardilysin (N-arginine dibasic convertase)
chr6_-_33548017 10.260 NM_001188
BAK1
BCL2-antagonist/killer 1
chr5_+_179247841 10.232 NM_003900
SQSTM1
sequestosome 1
chr12_-_15114495 10.206 NM_001175
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr17_+_79651072 10.197 HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chr10_+_131934637 10.138 NM_001199868
NM_006541
GLRX3

glutaredoxin 3

chr17_+_80193649 9.941 NM_001206952
SLC16A3
solute carrier family 16, member 3 (monocarboxylic acid transporter 4)
chr15_+_44829265 9.847 NM_003758
EIF3J
eukaryotic translation initiation factor 3, subunit J
chr2_+_86668488 9.769 NM_001146688
KDM3A
lysine (K)-specific demethylase 3A
chr17_-_76921453 9.730 NM_003255
TIMP2
TIMP metallopeptidase inhibitor 2
chr22_-_32808142 9.725 C22orf28
chromosome 22 open reading frame 28
chr1_+_151227209 9.675 PSMD4
proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
chr6_+_64281910 9.650 NM_003463
PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr2_-_65593866 9.510 NM_001128210
SPRED2
sprouty-related, EVH1 domain containing 2
chr1_+_40506384 9.489 CAP1
CAP, adenylate cyclase-associated protein 1 (yeast)
chr13_-_41593405 9.430 ELF1
E74-like factor 1 (ets domain transcription factor)
chr7_+_116312412 9.424 NM_000245
NM_001127500
MET

met proto-oncogene (hepatocyte growth factor receptor)

chr7_-_100881030 9.258 NM_014343
CLDN15
claudin 15
chr2_+_74057969 9.212 STAMBP
STAM binding protein
chr20_+_55043712 9.208 C20orf43
chromosome 20 open reading frame 43
chr20_+_55043691 9.188 C20orf43
chromosome 20 open reading frame 43
chr6_+_64231626 9.003 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr1_+_40506436 8.903 CAP1
CAP, adenylate cyclase-associated protein 1 (yeast)
chr1_+_40506449 8.800 CAP1
CAP, adenylate cyclase-associated protein 1 (yeast)
chr1_+_40506406 8.711 CAP1
CAP, adenylate cyclase-associated protein 1 (yeast)
chr17_+_57697036 8.699 NM_004859
CLTC
clathrin, heavy chain (Hc)
chr14_-_106791054 8.679 IGHV4-31
IGHV3-30
IGHA1
IGHD
IGHG1
IGHG2
IGHG3
IGHM
SCFV
immunoglobulin heavy variable 4-31
immunoglobulin heavy variable 3-30
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant delta
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 2 (G2m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
immunoglobulin heavy constant mu
single-chain Fv fragment
chr5_+_172410762 8.617 NM_003945
ATP6V0E1
ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
chr16_-_28621279 8.582 NM_001055
NM_177529
SULT1A1

sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1

chr15_+_78832787 8.487 PSMA4
proteasome (prosome, macropain) subunit, alpha type, 4
chr16_-_1429612 8.345 NM_001193389
NM_023076
UNKL

unkempt homolog (Drosophila)-like


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
15.35 6.78e-17 GO:0006521 regulation of cellular amino acid metabolic process
11.34 5.61e-16 GO:0051351 positive regulation of ligase activity
12.53 1.51e-15 GO:0031571 mitotic cell cycle G1/S transition DNA damage checkpoint
13.34 2.15e-15 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
13.34 2.15e-15 GO:0072395 signal transduction involved in cell cycle checkpoint
13.34 2.15e-15 GO:0072401 signal transduction involved in DNA integrity checkpoint
13.34 2.15e-15 GO:0072404 signal transduction involved in G1/S transition checkpoint
13.34 2.15e-15 GO:0072413 signal transduction involved in mitotic cell cycle checkpoint
13.34 2.15e-15 GO:0072422 signal transduction involved in DNA damage checkpoint
13.34 2.15e-15 GO:0072431 signal transduction involved in mitotic cell cycle G1/S transition DNA damage checkpoint
13.34 2.15e-15 GO:0072474 signal transduction involved in mitotic cell cycle G1/S checkpoint
11.42 2.59e-15 GO:0051443 positive regulation of ubiquitin-protein ligase activity
9.33 4.04e-15 GO:0031398 positive regulation of protein ubiquitination
12.00 4.37e-15 GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
12.71 6.74e-15 GO:0033238 regulation of cellular amine metabolic process
12.71 6.74e-15 GO:0071158 positive regulation of cell cycle arrest
10.87 9.06e-15 GO:2000045 regulation of G1/S transition of mitotic cell cycle
9.89 1.89e-14 GO:0051340 regulation of ligase activity
11.07 3.10e-14 GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
10.93 4.21e-14 GO:0031575 mitotic cell cycle G1/S transition checkpoint
10.93 4.21e-14 GO:0071779 G1/S transition checkpoint
10.65 7.68e-14 GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
9.90 8.89e-14 GO:0051438 regulation of ubiquitin-protein ligase activity
11.56 3.49e-13 GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
10.43 6.42e-13 GO:0000216 M/G1 transition of mitotic cell cycle
11.07 9.07e-13 GO:0051352 negative regulation of ligase activity
11.07 9.07e-13 GO:0051444 negative regulation of ubiquitin-protein ligase activity
7.14 4.29e-12 GO:0031396 regulation of protein ubiquitination
8.41 4.33e-12 GO:0000077 DNA damage checkpoint
9.46 5.58e-12 GO:0030330 DNA damage response, signal transduction by p53 class mediator
8.25 6.68e-12 GO:0000084 S phase of mitotic cell cycle
8.10 1.02e-11 GO:0051320 S phase
7.89 1.89e-11 GO:0031570 DNA integrity checkpoint
6.54 3.88e-11 GO:0010498 proteasomal protein catabolic process
6.54 3.88e-11 GO:0043161 proteasomal ubiquitin-dependent protein catabolic process
8.91 8.87e-11 GO:0031397 negative regulation of protein ubiquitination
7.19 1.55e-10 GO:0007093 mitotic cell cycle checkpoint
7.75 3.94e-10 GO:0090068 positive regulation of cell cycle process
7.60 5.82e-10 GO:0042770 signal transduction in response to DNA damage
6.70 7.32e-10 GO:0010565 regulation of cellular ketone metabolic process
4.26 1.71e-09 GO:0051603 proteolysis involved in cellular protein catabolic process
4.18 2.96e-09 GO:0044257 cellular protein catabolic process
4.34 5.15e-09 GO:0031401 positive regulation of protein modification process
6.13 1.49e-08 GO:0000082 G1/S transition of mitotic cell cycle
1.24 1.71e-08 GO:0009987 cellular process
3.91 1.97e-08 GO:0030163 protein catabolic process
5.75 1.98e-08 GO:0031400 negative regulation of protein modification process
4.12 2.03e-08 GO:0019941 modification-dependent protein catabolic process
4.09 2.42e-08 GO:0043632 modification-dependent macromolecule catabolic process
4.07 5.77e-08 GO:0006511 ubiquitin-dependent protein catabolic process
3.71 8.24e-08 GO:0032270 positive regulation of cellular protein metabolic process
1.45 8.38e-08 GO:0044237 cellular metabolic process
3.21 1.41e-07 GO:0044265 cellular macromolecule catabolic process
4.29 1.56e-07 GO:0007346 regulation of mitotic cell cycle
4.75 1.80e-07 GO:0000075 cell cycle checkpoint
2.45 2.71e-07 GO:0042981 regulation of apoptosis
2.67 2.73e-07 GO:0044093 positive regulation of molecular function
3.54 2.91e-07 GO:0051247 positive regulation of protein metabolic process
2.33 3.46e-07 GO:0050790 regulation of catalytic activity
2.43 3.78e-07 GO:0043067 regulation of programmed cell death
4.00 3.87e-07 GO:0051329 interphase of mitotic cell cycle
4.57 4.14e-07 GO:0071156 regulation of cell cycle arrest
2.81 4.38e-07 GO:0043085 positive regulation of catalytic activity
3.93 5.88e-07 GO:0051325 interphase
2.39 6.97e-07 GO:0010941 regulation of cell death
4.23 9.76e-07 GO:0051248 negative regulation of protein metabolic process
2.91 1.01e-06 GO:0009057 macromolecule catabolic process
1.37 1.94e-06 GO:0008152 metabolic process
4.25 1.94e-06 GO:0032269 negative regulation of cellular protein metabolic process
2.55 3.08e-06 GO:0006508 proteolysis
1.39 1.10e-05 GO:0044238 primary metabolic process
2.59 1.33e-05 GO:0012501 programmed cell death
2.04 1.80e-05 GO:0065009 regulation of molecular function
2.80 1.91e-05 GO:0000278 mitotic cell cycle
1.62 2.20e-05 GO:0006807 nitrogen compound metabolic process
3.36 2.23e-05 GO:0044419 interspecies interaction between organisms
2.28 2.26e-05 GO:0032268 regulation of cellular protein metabolic process
2.57 2.49e-05 GO:0006915 apoptosis
2.22 2.82e-05 GO:0051246 regulation of protein metabolic process
3.16 2.83e-05 GO:0016032 viral reproduction
3.36 3.86e-05 GO:0010564 regulation of cell cycle process
1.62 4.12e-05 GO:0034641 cellular nitrogen compound metabolic process
2.16 4.46e-05 GO:0044248 cellular catabolic process
2.43 6.49e-05 GO:0031399 regulation of protein modification process
2.30 1.15e-04 GO:0051704 multi-organism process
1.48 1.42e-04 GO:0044260 cellular macromolecule metabolic process
1.65 1.54e-04 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
2.19 1.55e-04 GO:0007049 cell cycle
2.09 2.33e-04 GO:0010604 positive regulation of macromolecule metabolic process
1.43 2.48e-04 GO:0043170 macromolecule metabolic process
1.95 2.57e-04 GO:0009056 catabolic process
2.27 3.03e-04 GO:0008219 cell death
2.26 3.51e-04 GO:0016265 death
1.68 4.48e-04 GO:0006950 response to stress
1.59 4.88e-04 GO:0019538 protein metabolic process
1.66 5.17e-04 GO:0044267 cellular protein metabolic process
2.03 5.89e-04 GO:0031325 positive regulation of cellular metabolic process
1.99 7.39e-04 GO:0009893 positive regulation of metabolic process
2.63 1.10e-03 GO:0006974 response to DNA damage stimulus
2.46 1.12e-03 GO:0051726 regulation of cell cycle
2.37 1.35e-03 GO:0022403 cell cycle phase
2.81 1.54e-03 GO:0043086 negative regulation of catalytic activity
2.23 1.84e-03 GO:0022402 cell cycle process
1.63 3.15e-03 GO:0048519 negative regulation of biological process
2.17 3.78e-03 GO:0033554 cellular response to stress
1.75 4.52e-03 GO:0016070 RNA metabolic process
1.91 4.55e-03 GO:0002376 immune system process
1.65 5.97e-03 GO:0048523 negative regulation of cellular process
2.46 6.65e-03 GO:0016071 mRNA metabolic process
1.63 8.33e-03 GO:0090304 nucleic acid metabolic process
2.88 9.89e-03 GO:0009894 regulation of catabolic process
5.87 1.07e-02 GO:0045454 cell redox homeostasis
2.44 1.16e-02 GO:0044092 negative regulation of molecular function
1.53 1.59e-02 GO:0048518 positive regulation of biological process
1.56 2.18e-02 GO:0048522 positive regulation of cellular process
1.29 3.24e-02 GO:0050896 response to stimulus
1.39 3.74e-02 GO:0051716 cellular response to stimulus
3.67 4.73e-02 GO:0050900 leukocyte migration

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
15.37 2.84e-21 GO:0000502 proteasome complex
1.38 4.48e-11 GO:0005737 cytoplasm
1.20 2.97e-07 GO:0005622 intracellular
1.20 3.25e-06 GO:0044424 intracellular part
15.49 4.70e-06 GO:0005839 proteasome core complex
1.77 1.71e-05 GO:0005829 cytosol
1.57 1.45e-04 GO:0043234 protein complex
24.21 1.54e-04 GO:0019773 proteasome core complex, alpha-subunit complex
21.52 3.38e-04 GO:0005838 proteasome regulatory particle
16.14 1.99e-03 GO:0022624 proteasome accessory complex
1.44 2.50e-03 GO:0032991 macromolecular complex
1.27 1.87e-02 GO:0044444 cytoplasmic part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.46 2.66e-12 GO:0005515 protein binding
1.18 5.38e-06 GO:0005488 binding
14.76 1.04e-05 GO:0004298 threonine-type endopeptidase activity
14.76 1.04e-05 GO:0070003 threonine-type peptidase activity
9.69 1.88e-05 GO:0003823 antigen binding
8.75 4.12e-03 GO:0015036 disulfide oxidoreductase activity
6.08 1.64e-02 GO:0005097 Rab GTPase activator activity
2.82 1.93e-02 GO:0032403 protein complex binding
2.51 2.03e-02 GO:0004175 endopeptidase activity
29.05 2.43e-02 GO:0015037 peptide disulfide oxidoreductase activity
8.30 2.44e-02 GO:0015035 protein disulfide oxidoreductase activity
2.15 3.01e-02 GO:0008233 peptidase activity