Motif ID: NFKB1_REL_RELA.p2

Z-value: 2.687


Transcription factors associated with NFKB1_REL_RELA.p2:

Gene SymbolEntrez IDGene Name
NFKB1 4790 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
REL 5966 v-rel reticuloendotheliosis viral oncogene homolog (avian)
RELA 5970 v-rel reticuloendotheliosis viral oncogene homolog A (avian)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NFKB1chr4_+_1034224790.597.4e-22Click!
RELchr2_+_611087750.571.8e-20Click!
RELAchr11_-_654304270.335.8e-07Click!


Activity profile for motif NFKB1_REL_RELA.p2.

activity profile for motif NFKB1_REL_RELA.p2


Sorted Z-values histogram for motif NFKB1_REL_RELA.p2

Sorted Z-values for motif NFKB1_REL_RELA.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFKB1_REL_RELA.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr14_-_35873823 65.610 NM_020529
NFKBIA
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
chr19_-_41859332 55.388 TGFB1
transforming growth factor, beta 1
chr19_-_41859830 53.119 NM_000660
TGFB1
transforming growth factor, beta 1
chr19_-_41859519 52.961 TGFB1
transforming growth factor, beta 1
chr5_-_149792276 48.621 CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chr6_-_31324975 43.030 NM_005514
HLA-B
major histocompatibility complex, class I, B
chr6_-_32551993 41.126 HLA-DRB1
HLA-DRB4
HLA-DRB5
major histocompatibility complex, class II, DR beta 1
major histocompatibility complex, class II, DR beta 4
major histocompatibility complex, class II, DR beta 5
chr6_-_31324955 39.796 HLA-B
major histocompatibility complex, class I, B
chr5_-_149792370 39.795 NM_001025158
NM_001025159
NM_004355
CD74


CD74 molecule, major histocompatibility complex, class II invariant chain


chr22_-_37640287 39.677 NM_002872
RAC2
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr6_+_29974352 39.197 HLA-J
major histocompatibility complex, class I, J (pseudogene)
chr19_-_41859253 37.478 TGFB1
transforming growth factor, beta 1
chr22_+_22758538 37.303


chr6_+_29910246 32.299 NM_001242758
NM_002116
HLA-A

major histocompatibility complex, class I, A

chr6_-_31324898 32.233 HLA-B
major histocompatibility complex, class I, B
chr12_+_7055736 31.431 NM_080548
PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr17_+_40440481 31.308 STAT5A
signal transducer and activator of transcription 5A
chr6_+_32605182 29.970 NM_002122
HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
chr19_+_1067536 29.034 HMHA1
histocompatibility (minor) HA-1
chr16_+_85932766 28.957 NM_002163
IRF8
interferon regulatory factor 8
chr22_-_37640187 28.881 RAC2
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr16_+_50776012 27.551 NM_001042412
CYLD
cylindromatosis (turban tumor syndrome)
chr5_-_150466696 27.008 NM_001252391
NM_001252392
TNIP1

TNFAIP3 interacting protein 1

chr12_+_7055753 25.981 PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr22_+_23213671 25.454 IGLV4-3
immunoglobulin lambda variable 4-3
chr6_-_31324564 24.792 HLA-B
HLA-C
major histocompatibility complex, class I, B
major histocompatibility complex, class I, C
chr4_+_103422730 24.325 NFKB1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
chr11_-_3862183 23.670 NM_001665
RHOG
ras homolog gene family, member G (rho G)
chr16_+_50775960 23.604 NM_001042355
NM_015247
CYLD

cylindromatosis (turban tumor syndrome)

chr19_+_42381189 23.126 NM_001783
NM_021601
CD79A

CD79a molecule, immunoglobulin-associated alpha

chr4_+_103422479 23.018 NM_001165412
NM_003998
NFKB1

nuclear factor of kappa light polypeptide gene enhancer in B-cells 1

chr4_+_103422822 22.675 NFKB1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
chr15_+_85923739 22.306 NM_006738
NM_007200
AKAP13

A kinase (PRKA) anchor protein 13

chr19_+_2476122 21.998 NM_015675
GADD45B
growth arrest and DNA-damage-inducible, beta
chr14_+_24605366 21.574 NM_006263
NM_176783
PSME1

proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)

chr5_-_131826426 21.462 NM_002198
IRF1
interferon regulatory factor 1
chr1_-_27961623 21.430 NM_005248
FGR
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog
chr13_-_46756326 21.120 NM_002298
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr4_+_103422553 20.886 NFKB1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
chr17_+_7461591 20.580 NM_001198622
NM_001198623
NM_001198624
NM_003808
NM_172087
NM_172088
TNFSF13





tumor necrosis factor (ligand) superfamily, member 13





chr11_+_102188180 20.332 NM_001165
NM_182962
BIRC3

baculoviral IAP repeat containing 3

chr5_-_150460599 19.016 NM_001252385
NM_001252386
NM_001252393
NM_006058
TNIP1



TNFAIP3 interacting protein 1



chr6_-_32811773 18.831 NM_148919
PSMB8
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
chr22_-_37545944 18.650 NM_000878
IL2RB
interleukin 2 receptor, beta
chr22_+_22712091 18.629 IGLV1-44
IGL@
immunoglobulin lambda variable 1-44
immunoglobulin lambda locus
chr2_+_68961912 18.613 NM_001007231
NM_001166277
ARHGAP25

Rho GTPase activating protein 25

chr6_+_29855506 18.546


chr5_-_150460550 17.992 TNIP1
TNFAIP3 interacting protein 1
chr14_-_96180402 17.780 NM_001098725
NM_021966
TCL1A

T-cell leukemia/lymphoma 1A

chr10_+_104155431 17.354 NM_002502
NFKB2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
chr22_+_23222897 17.280 CYAT1
immunoglobulin lambda light chain-like
chr11_-_3862137 17.237 RHOG
ras homolog gene family, member G (rho G)
chr5_-_150467220 17.212 NM_001252390
TNIP1
TNFAIP3 interacting protein 1
chr16_+_3115611 17.103 NM_001012635
IL32
interleukin 32
chr2_+_69001932 17.065 NM_001166276
NM_014882
ARHGAP25

Rho GTPase activating protein 25

chr22_+_23134980 17.007


chr10_+_104154228 16.987 NM_001077493
NM_001077494
NFKB2

nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)

chr6_+_138188352 16.974 NM_006290
TNFAIP3
tumor necrosis factor, alpha-induced protein 3
chr5_-_171615239 16.839 STK10
serine/threonine kinase 10
chr17_-_34207308 16.626 NM_002985
CCL5
chemokine (C-C motif) ligand 5
chr16_+_3115312 16.583 NM_001012631
NM_001012633
NM_001012718
NM_004221
IL32



interleukin 32



chr6_-_31704281 16.555 CLIC1
chloride intracellular channel 1
chr6_-_31704093 16.330 CLIC1
chloride intracellular channel 1
chrX_+_64887510 16.256 NM_002444
MSN
moesin
chr10_-_3827205 16.231 KLF6
Kruppel-like factor 6
chr11_+_1889902 16.188 NM_001013253
LSP1
lymphocyte-specific protein 1
chr6_-_31704070 16.146 CLIC1
chloride intracellular channel 1
chr6_+_29910308 16.089 HLA-A
major histocompatibility complex, class I, A
chr1_-_202130677 15.940 NM_001199797
NM_002832
PTPN7

protein tyrosine phosphatase, non-receptor type 7

chrX_+_64887534 15.834 MSN
moesin
chr6_-_31704272 15.832 CLIC1
chloride intracellular channel 1
chr6_-_31704287 15.734 CLIC1
chloride intracellular channel 1
chr16_+_3115638 15.729 NM_001012634
IL32
interleukin 32
chr2_-_43453737 15.600 NM_006887
ZFP36L2
zinc finger protein 36, C3H type-like 2
chr2_-_197036262 15.398 STK17B
serine/threonine kinase 17b
chrX_+_64887593 15.364 MSN
moesin
chr1_+_203274646 15.286 NM_006763
BTG2
BTG family, member 2
chr2_+_233925035 15.286 NM_001017915
NM_005541
INPP5D

inositol polyphosphate-5-phosphatase, 145kDa

chr16_+_3115639 15.180 IL32
interleukin 32
chr5_-_171615320 15.006 NM_005990
STK10
serine/threonine kinase 10
chr6_-_31704304 14.947 CLIC1
chloride intracellular channel 1
chr1_-_183560010 14.809 NM_001127651
NCF2
neutrophil cytosolic factor 2
chr3_-_156878481 14.803 NM_020307
CCNL1
cyclin L1
chr12_-_57504088 14.728 NM_001178079
STAT6
signal transducer and activator of transcription 6, interleukin-4 induced
chr14_-_24616429 14.591 PSME2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr13_-_46756295 14.484 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr1_-_47655603 14.456 PDZK1IP1
PDZK1 interacting protein 1
chr19_+_50922194 14.218 NM_001243998
NM_001243999
NM_001244000
NM_003121
SPIB



Spi-B transcription factor (Spi-1/PU.1 related)



chr6_-_31704318 13.791 NM_001288
CLIC1
chloride intracellular channel 1
chr2_-_43453146 13.764 ZFP36L2
zinc finger protein 36, C3H type-like 2
chr5_-_171615095 13.642 STK10
serine/threonine kinase 10
chr19_+_45504686 13.436 NM_006509
RELB
v-rel reticuloendotheliosis viral oncogene homolog B
chr6_+_116692098 13.342 NM_013352
DSE
dermatan sulfate epimerase
chr7_-_150497398 13.207 NM_001101311
NM_001101312
NM_001101314
TMEM176B


transmembrane protein 176B


chr16_+_27325269 13.170 IL4R
interleukin 4 receptor
chr1_-_47655723 13.164 NM_005764
PDZK1IP1
PDZK1 interacting protein 1
chr1_-_183559669 13.146 NM_000433
NM_001190789
NM_001190794
NCF2


neutrophil cytosolic factor 2


chr2_-_43453724 13.071 ZFP36L2
zinc finger protein 36, C3H type-like 2
chr2_+_61108702 12.939 REL
v-rel reticuloendotheliosis viral oncogene homolog (avian)
chr2_+_233925104 12.749 INPP5D
inositol polyphosphate-5-phosphatase, 145kDa
chr9_-_110250707 12.521 KLF4
Kruppel-like factor 4 (gut)
chr8_-_103667882 12.489 NM_005655
KLF10
Kruppel-like factor 10
chr14_+_24605393 12.297 PSME1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr1_-_159895258 12.216 TAGLN2
transgelin 2
chr15_+_89182038 12.099 NM_002201
ISG20
interferon stimulated exonuclease gene 20kDa
chr6_+_29855349 12.085 HLA-H
major histocompatibility complex, class I, H (pseudogene)
chr16_+_27325244 12.024 NM_000418
NM_001008699
IL4R

interleukin 4 receptor

chr19_-_2041862 11.915 MKNK2
MAP kinase interacting serine/threonine kinase 2
chr17_+_72462521 11.866 NM_007261
CD300A
CD300a molecule
chr6_+_29894105 11.757


chr19_+_45971249 11.718 NM_001114171
NM_006732
FOSB

FBJ murine osteosarcoma viral oncogene homolog B

chr1_-_27952591 11.664 NM_001042747
FGR
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog
chr2_+_61108724 11.581 NM_002908
REL
v-rel reticuloendotheliosis viral oncogene homolog (avian)
chr2_+_61108775 11.551 REL
v-rel reticuloendotheliosis viral oncogene homolog (avian)
chr10_+_30722856 11.533 NM_001244134
NM_005204
MAP3K8

mitogen-activated protein kinase kinase kinase 8

chr2_+_219264477 11.482 NM_021198
NM_182642
CTDSP1

CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1

chr20_-_57582152 11.426 CTSZ
cathepsin Z
chr1_-_59248287 11.348 JUN
jun proto-oncogene
chr20_-_4795768 11.335 NM_170774
RASSF2
Ras association (RalGDS/AF-6) domain family member 2
chr6_+_14117486 11.230 NM_001251901
CD83
CD83 molecule
chr12_-_6716475 11.145 CHD4
chromodomain helicase DNA binding protein 4
chr19_+_1071208 11.007 HMHA1
histocompatibility (minor) HA-1
chr5_-_178054001 10.989 NM_020666
CLK4
CDC-like kinase 4
chr4_+_154605441 10.988 TLR2
toll-like receptor 2
chr19_+_42364322 10.719 RPS19
ribosomal protein S19
chr7_-_105925329 10.633 NAMPT
nicotinamide phosphoribosyltransferase
chr3_+_53195214 10.591 NM_006254
NM_212539
PRKCD

protein kinase C, delta

chr14_+_70078313 10.590 KIAA0247
KIAA0247
chr14_-_24615772 10.563 PSME2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr20_+_35202956 10.554 NM_001199535
NM_001199515
TGIF2-C20ORF24
TGIF2
TGIF2-C20orf24 readthrough
TGFB-induced factor homeobox 2
chr19_+_859673 10.325 CFD
complement factor D (adipsin)
chr19_+_45251933 10.206 NM_005178
BCL3
B-cell CLL/lymphoma 3
chr19_+_1067114 10.194 NM_012292
HMHA1
histocompatibility (minor) HA-1
chr16_+_53468406 10.188 RBL2
retinoblastoma-like 2 (p130)
chr17_-_40540491 10.160 NM_003150
NM_139276
STAT3

signal transducer and activator of transcription 3 (acute-phase response factor)

chr19_+_42363987 10.148 NM_001022
RPS19
ribosomal protein S19
chr1_-_202129118 10.124 NM_080588
PTPN7
protein tyrosine phosphatase, non-receptor type 7
chr1_-_25256767 10.076 NM_004350
RUNX3
runt-related transcription factor 3
chr14_-_64970319 10.026 NM_006977
ZBTB25
zinc finger and BTB domain containing 25
chr11_-_33891485 10.006 NM_001142315
LMO2
LIM domain only 2 (rhombotin-like 1)
chr1_+_26856252 9.968 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr2_-_89513056 9.804 IGKC
immunoglobulin kappa constant
chr11_-_33891361 9.804 NM_001142316
LMO2
LIM domain only 2 (rhombotin-like 1)
chr4_+_154605421 9.792 NM_003264
TLR2
toll-like receptor 2
chr11_-_57335756 9.734 NM_198183
UBE2L6
ubiquitin-conjugating enzyme E2L 6
chr2_-_197036301 9.706 NM_004226
STK17B
serine/threonine kinase 17b
chr1_-_184943532 9.608 FAM129A
family with sequence similarity 129, member A
chr1_-_202129705 9.599 PTPN7
protein tyrosine phosphatase, non-receptor type 7
chr14_+_70078309 9.554 NM_014734
KIAA0247
KIAA0247
chr19_+_4229494 9.515 NM_005755
EBI3
Epstein-Barr virus induced 3
chr17_+_38474513 9.470 RARA
retinoic acid receptor, alpha
chr8_+_144635556 9.453 NM_001166237
GSDMD
gasdermin D
chr1_+_26872306 9.447 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr14_-_24615794 9.337 NM_002818
PSME2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr17_-_40540359 9.268 NM_213662
STAT3
signal transducer and activator of transcription 3 (acute-phase response factor)
chr12_-_6716550 9.233 NM_001273
CHD4
chromodomain helicase DNA binding protein 4
chr21_+_34775729 9.130 IFNGR2
interferon gamma receptor 2 (interferon gamma transducer 1)
chr19_+_1067293 9.103 HMHA1
histocompatibility (minor) HA-1
chr6_+_37137882 9.032 NM_001243186
NM_002648
PIM1

pim-1 oncogene

chr4_-_185395616 9.012 NM_002199
IRF2
interferon regulatory factor 2
chr5_-_142783200 8.899 NR3C1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr17_+_38474544 8.893 RARA
retinoic acid receptor, alpha
chr22_-_37882214 8.736 NM_001166343
NM_002405
MFNG

MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

chr2_-_235405692 8.692 NM_005737
ARL4C
ADP-ribosylation factor-like 4C
chr22_+_22764094 8.687


chr4_-_74964996 8.676 NM_002089
CXCL2
chemokine (C-X-C motif) ligand 2
chr19_+_860615 8.634 CFD
complement factor D (adipsin)
chr1_-_183604885 8.597 NM_005717
ARPC5
actin related protein 2/3 complex, subunit 5, 16kDa
chr16_+_81812897 8.592 NM_002661
PLCG2
phospholipase C, gamma 2 (phosphatidylinositol-specific)
chr19_+_42364262 8.403 RPS19
ribosomal protein S19
chr10_-_125851850 8.386 NM_014863
NM_015892
CHST15

carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15

chr6_-_29527701 8.359 NM_006398
UBD
ubiquitin D
chr5_-_142783059 8.333 NR3C1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr12_-_54813010 8.327 NM_002205
ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr17_+_38474472 8.300 NM_001145301
NM_001145302
RARA

retinoic acid receptor, alpha

chr19_-_6591012 8.273 CD70
CD70 molecule
chr21_+_34775189 8.248 NM_005534
IFNGR2
interferon gamma receptor 2 (interferon gamma transducer 1)
chr6_+_292033 8.247 NM_020185
DUSP22
dual specificity phosphatase 22
chr16_+_81812899 8.182 PLCG2
phospholipase C, gamma 2 (phosphatidylinositol-specific)
chr12_+_105501537 8.095 KIAA1033
KIAA1033
chr21_+_34775740 8.069 IFNGR2
interferon gamma receptor 2 (interferon gamma transducer 1)
chr20_+_44746889 8.059 NM_001250
NM_152854
CD40

CD40 molecule, TNF receptor superfamily member 5

chr11_+_118307072 7.988 NM_001197104
NM_005933
MLL

myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)

chr2_+_17935124 7.987 NM_182625
GEN1
Gen endonuclease homolog 1 (Drosophila)
chr17_+_72462766 7.979 CD300A
CD300a molecule
chr11_+_58910173 7.923 NM_001142519
NM_001142520
NM_001142521
FAM111A


family with sequence similarity 111, member A


chr11_-_62446544 7.896 UBXN1
UBX domain protein 1
chr22_-_24059436 7.847


chr19_+_14142459 7.846 IL27RA
interleukin 27 receptor, alpha
chr7_+_150497840 7.798 NM_018487
TMEM176A
transmembrane protein 176A
chr19_-_41859767 7.750 TGFB1
transforming growth factor, beta 1
chr10_-_12085022 7.721 NM_080599
UPF2
UPF2 regulator of nonsense transcripts homolog (yeast)
chr12_-_54813002 7.705 ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr4_-_74964836 7.696 CXCL2
chemokine (C-X-C motif) ligand 2
chr19_+_14142611 7.637 IL27RA
interleukin 27 receptor, alpha
chr2_+_10183630 7.616 NM_003597
NM_001177716
KLF11

Kruppel-like factor 11

chr4_-_71532206 7.606 IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr19_-_11688441 7.569 ACP5
acid phosphatase 5, tartrate resistant
chr11_+_67810446 7.559 NM_006053
TCIRG1
T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
chr17_+_16318911 7.548 TRPV2
transient receptor potential cation channel, subfamily V, member 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.31 2.39e-21 GO:0065007 biological regulation
2.50 3.67e-21 GO:0006955 immune response
1.33 5.67e-21 GO:0050789 regulation of biological process
2.11 1.26e-20 GO:0002376 immune system process
1.68 1.49e-20 GO:0048518 positive regulation of biological process
1.34 1.81e-19 GO:0050794 regulation of cellular process
1.68 7.77e-18 GO:0048522 positive regulation of cellular process
1.18 8.42e-18 GO:0009987 cellular process
1.54 1.13e-16 GO:0060255 regulation of macromolecule metabolic process
1.50 1.91e-16 GO:0023052 signaling
2.37 3.99e-16 GO:0002682 regulation of immune system process
1.51 2.43e-15 GO:0007165 signal transduction
1.39 7.60e-15 GO:0043170 macromolecule metabolic process
1.44 1.10e-14 GO:0051716 cellular response to stimulus
1.63 2.20e-14 GO:0048519 negative regulation of biological process
1.45 2.60e-14 GO:0019222 regulation of metabolic process
2.66 2.64e-14 GO:0002684 positive regulation of immune system process
1.48 3.24e-14 GO:0031323 regulation of cellular metabolic process
1.66 4.96e-14 GO:0048523 negative regulation of cellular process
2.16 7.86e-14 GO:0006952 defense response
1.60 8.29e-14 GO:0010556 regulation of macromolecule biosynthetic process
1.31 1.71e-13 GO:0050896 response to stimulus
1.46 4.93e-13 GO:0080090 regulation of primary metabolic process
1.90 1.81e-12 GO:0010604 positive regulation of macromolecule metabolic process
1.56 2.58e-12 GO:0010468 regulation of gene expression
1.53 3.62e-12 GO:0009889 regulation of biosynthetic process
1.54 4.51e-12 GO:0031326 regulation of cellular biosynthetic process
1.67 4.57e-12 GO:0048583 regulation of response to stimulus
1.84 4.71e-12 GO:0009893 positive regulation of metabolic process
1.57 7.26e-12 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.96 9.57e-12 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.37 2.18e-11 GO:0044260 cellular macromolecule metabolic process
1.58 2.37e-11 GO:0042221 response to chemical stimulus
1.57 3.03e-11 GO:0051252 regulation of RNA metabolic process
1.59 4.00e-11 GO:0006355 regulation of transcription, DNA-dependent
1.54 6.40e-11 GO:0006950 response to stress
2.03 9.27e-11 GO:0048584 positive regulation of response to stimulus
2.06 3.03e-10 GO:0010557 positive regulation of macromolecule biosynthetic process
1.80 4.72e-10 GO:0031325 positive regulation of cellular metabolic process
1.27 5.81e-10 GO:0044238 primary metabolic process
2.37 1.11e-09 GO:0050776 regulation of immune response
1.48 2.08e-09 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
2.07 3.01e-09 GO:0010628 positive regulation of gene expression
1.47 3.44e-09 GO:0051171 regulation of nitrogen compound metabolic process
1.85 8.39e-09 GO:0032774 RNA biosynthetic process
2.45 1.03e-08 GO:0045087 innate immune response
1.71 2.13e-08 GO:0010033 response to organic substance
2.07 2.64e-08 GO:0045893 positive regulation of transcription, DNA-dependent
1.81 3.07e-08 GO:0009605 response to external stimulus
1.86 5.64e-08 GO:0006351 transcription, DNA-dependent
1.81 7.21e-08 GO:0042127 regulation of cell proliferation
1.77 7.75e-08 GO:0043067 regulation of programmed cell death
1.77 8.56e-08 GO:0042981 regulation of apoptosis
1.86 9.44e-08 GO:0009891 positive regulation of biosynthetic process
1.56 1.06e-07 GO:0007166 cell surface receptor linked signaling pathway
1.76 1.18e-07 GO:0010941 regulation of cell death
1.86 1.44e-07 GO:0031328 positive regulation of cellular biosynthetic process
1.22 1.57e-07 GO:0008152 metabolic process
2.71 1.89e-07 GO:0002694 regulation of leukocyte activation
1.39 1.92e-07 GO:0048856 anatomical structure development
2.80 2.01e-07 GO:0051249 regulation of lymphocyte activation
2.66 2.52e-07 GO:0050865 regulation of cell activation
1.34 2.86e-07 GO:0032502 developmental process
1.90 3.08e-07 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.81 3.32e-07 GO:0050793 regulation of developmental process
1.87 4.01e-07 GO:0051173 positive regulation of nitrogen compound metabolic process
2.42 4.53e-07 GO:0031347 regulation of defense response
2.51 4.89e-07 GO:0050778 positive regulation of immune response
1.41 5.43e-07 GO:0048731 system development
2.15 5.60e-07 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.95 6.11e-07 GO:0051254 positive regulation of RNA metabolic process
4.51 8.21e-07 GO:0034138 toll-like receptor 3 signaling pathway
3.01 9.28e-07 GO:0031349 positive regulation of defense response
1.35 1.20e-06 GO:0007275 multicellular organismal development
2.89 1.20e-06 GO:0002764 immune response-regulating signaling pathway
1.51 1.25e-06 GO:0048513 organ development
1.52 1.30e-06 GO:0010467 gene expression
1.38 1.31e-06 GO:0019538 protein metabolic process
2.92 1.42e-06 GO:0045088 regulation of innate immune response
2.88 1.45e-06 GO:0002696 positive regulation of leukocyte activation
2.19 1.67e-06 GO:0007243 intracellular protein kinase cascade
2.19 1.67e-06 GO:0023014 signal transduction via phosphorylation event
4.37 1.69e-06 GO:0002756 MyD88-independent toll-like receptor signaling pathway
2.67 1.87e-06 GO:0002253 activation of immune response
2.89 2.07e-06 GO:0002757 immune response-activating signal transduction
2.83 2.50e-06 GO:0050867 positive regulation of cell activation
1.62 2.78e-06 GO:0051239 regulation of multicellular organismal process
2.33 3.24e-06 GO:0045597 positive regulation of cell differentiation
1.52 3.78e-06 GO:0016070 RNA metabolic process
1.89 3.88e-06 GO:0031327 negative regulation of cellular biosynthetic process
1.53 3.91e-06 GO:0009059 macromolecule biosynthetic process
1.53 4.42e-06 GO:0034645 cellular macromolecule biosynthetic process
1.90 4.52e-06 GO:0010558 negative regulation of macromolecule biosynthetic process
2.01 4.57e-06 GO:0045892 negative regulation of transcription, DNA-dependent
2.00 5.21e-06 GO:0051253 negative regulation of RNA metabolic process
1.91 5.34e-06 GO:0071310 cellular response to organic substance
3.04 5.46e-06 GO:0002252 immune effector process
1.87 5.47e-06 GO:0009890 negative regulation of biosynthetic process
1.75 5.61e-06 GO:0031324 negative regulation of cellular metabolic process
2.86 7.32e-06 GO:0051251 positive regulation of lymphocyte activation
1.72 8.50e-06 GO:0070887 cellular response to chemical stimulus
3.90 1.01e-05 GO:0008063 Toll signaling pathway
3.90 1.01e-05 GO:0034142 toll-like receptor 4 signaling pathway
2.41 1.30e-05 GO:0001817 regulation of cytokine production
1.90 1.60e-05 GO:0051172 negative regulation of nitrogen compound metabolic process
1.21 1.84e-05 GO:0044237 cellular metabolic process
1.90 1.89e-05 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
2.31 2.07e-05 GO:0034097 response to cytokine stimulus
1.71 2.08e-05 GO:0010605 negative regulation of macromolecule metabolic process
2.08 2.14e-05 GO:0032583 regulation of gene-specific transcription
3.63 2.46e-05 GO:0002224 toll-like receptor signaling pathway
1.67 2.59e-05 GO:0006793 phosphorus metabolic process
1.67 2.59e-05 GO:0006796 phosphate metabolic process
1.80 2.91e-05 GO:0006468 protein phosphorylation
3.49 3.15e-05 GO:0002758 innate immune response-activating signal transduction
1.97 3.28e-05 GO:0080134 regulation of response to stress
1.56 3.30e-05 GO:0035556 intracellular signal transduction
2.17 3.55e-05 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
3.94 3.72e-05 GO:0034130 toll-like receptor 1 signaling pathway
3.94 3.72e-05 GO:0034134 toll-like receptor 2 signaling pathway
1.88 4.39e-05 GO:0010629 negative regulation of gene expression
2.54 4.59e-05 GO:0071345 cellular response to cytokine stimulus
1.86 4.80e-05 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
2.10 4.98e-05 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.96 5.08e-05 GO:0006935 chemotaxis
1.96 5.08e-05 GO:0042330 taxis
3.42 5.15e-05 GO:0002218 activation of innate immune response
1.52 5.46e-05 GO:0009653 anatomical structure morphogenesis
1.54 6.31e-05 GO:0009966 regulation of signal transduction
1.36 6.40e-05 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
2.02 6.51e-05 GO:0051094 positive regulation of developmental process
1.77 6.70e-05 GO:2000026 regulation of multicellular organismal development
3.06 6.74e-05 GO:0045089 positive regulation of innate immune response
3.47 6.89e-05 GO:0002221 pattern recognition receptor signaling pathway
1.66 7.05e-05 GO:0009892 negative regulation of metabolic process
2.30 7.11e-05 GO:0051270 regulation of cellular component movement
1.63 7.15e-05 GO:0010646 regulation of cell communication
1.38 7.44e-05 GO:0044267 cellular protein metabolic process
1.94 8.01e-05 GO:0008284 positive regulation of cell proliferation
1.40 1.17e-04 GO:0090304 nucleic acid metabolic process
3.72 1.18e-04 GO:0002755 MyD88-dependent toll-like receptor signaling pathway
2.68 1.21e-04 GO:0050863 regulation of T cell activation
1.79 1.31e-04 GO:0045595 regulation of cell differentiation
1.69 1.71e-04 GO:0040011 locomotion
3.41 1.92e-04 GO:0002443 leukocyte mediated immunity
2.55 2.03e-04 GO:0019221 cytokine-mediated signaling pathway
2.36 2.07e-04 GO:0045321 leukocyte activation
1.47 2.43e-04 GO:0023051 regulation of signaling
1.44 2.54e-04 GO:0006464 protein modification process
1.58 4.71e-04 GO:0051246 regulation of protein metabolic process
2.63 6.96e-04 GO:0051272 positive regulation of cellular component movement
3.50 7.51e-04 GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
2.76 7.75e-04 GO:0050870 positive regulation of T cell activation
1.59 8.90e-04 GO:0032268 regulation of cellular protein metabolic process
1.60 9.63e-04 GO:0032879 regulation of localization
1.82 1.01e-03 GO:0006928 cellular component movement
1.65 1.05e-03 GO:0016310 phosphorylation
1.29 1.07e-03 GO:0006807 nitrogen compound metabolic process
2.17 1.13e-03 GO:0040012 regulation of locomotion
1.40 1.21e-03 GO:0043412 macromolecule modification
3.41 1.23e-03 GO:0002250 adaptive immune response
1.62 1.39e-03 GO:0051704 multi-organism process
1.47 1.51e-03 GO:0065009 regulation of molecular function
1.93 1.88e-03 GO:0040008 regulation of growth
1.28 1.96e-03 GO:0016043 cellular component organization
2.44 1.98e-03 GO:0070201 regulation of establishment of protein localization
2.65 2.11e-03 GO:0007568 aging
1.84 2.15e-03 GO:0009967 positive regulation of signal transduction
1.88 2.33e-03 GO:0060548 negative regulation of cell death
2.19 2.43e-03 GO:0030334 regulation of cell migration
1.63 2.52e-03 GO:0051128 regulation of cellular component organization
2.61 2.89e-03 GO:0002237 response to molecule of bacterial origin
2.61 2.89e-03 GO:0034762 regulation of transmembrane transport
5.11 3.35e-03 GO:0042345 regulation of NF-kappaB import into nucleus
2.17 3.42e-03 GO:2000145 regulation of cell motility
2.68 3.74e-03 GO:0032496 response to lipopolysaccharide
1.88 3.82e-03 GO:0043069 negative regulation of programmed cell death
1.63 3.89e-03 GO:0031399 regulation of protein modification process
1.62 4.28e-03 GO:0044093 positive regulation of molecular function
3.29 4.30e-03 GO:0002699 positive regulation of immune effector process
1.33 4.33e-03 GO:0044249 cellular biosynthetic process
2.17 4.39e-03 GO:0009617 response to bacterium
3.40 4.62e-03 GO:0002449 lymphocyte mediated immunity
3.16 4.85e-03 GO:0042306 regulation of protein import into nucleus
2.45 5.25e-03 GO:0051223 regulation of protein transport
2.96 5.52e-03 GO:0046822 regulation of nucleocytoplasmic transport
2.49 5.72e-03 GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter
1.87 5.79e-03 GO:0043066 negative regulation of apoptosis
2.34 5.81e-03 GO:0046649 lymphocyte activation
1.78 5.87e-03 GO:0010647 positive regulation of cell communication
1.20 6.67e-03 GO:0032501 multicellular organismal process
8.64 6.75e-03 GO:0002828 regulation of type 2 immune response
1.77 7.35e-03 GO:0023056 positive regulation of signaling
1.35 7.95e-03 GO:0048869 cellular developmental process
2.76 8.04e-03 GO:0032386 regulation of intracellular transport
1.32 8.42e-03 GO:0009058 biosynthetic process
2.04 8.78e-03 GO:0051130 positive regulation of cellular component organization
1.36 8.86e-03 GO:0030154 cell differentiation
2.09 9.12e-03 GO:0010740 positive regulation of intracellular protein kinase cascade
2.47 9.59e-03 GO:0040017 positive regulation of locomotion
1.66 1.01e-02 GO:0042325 regulation of phosphorylation
1.56 1.02e-02 GO:0009611 response to wounding
1.95 1.11e-02 GO:0007389 pattern specification process
2.15 1.30e-02 GO:0001558 regulation of cell growth
1.27 1.36e-02 GO:0034641 cellular nitrogen compound metabolic process
1.25 1.37e-02 GO:0071840 cellular component organization or biogenesis
3.78 1.38e-02 GO:0051403 stress-activated MAPK cascade
2.89 1.39e-02 GO:0033157 regulation of intracellular protein transport
2.56 1.40e-02 GO:0001819 positive regulation of cytokine production
1.76 1.54e-02 GO:0001775 cell activation
2.21 1.56e-02 GO:0043193 positive regulation of gene-specific transcription
1.33 1.60e-02 GO:0065008 regulation of biological quality
3.39 1.74e-02 GO:0060333 interferon-gamma-mediated signaling pathway
2.20 1.75e-02 GO:0032880 regulation of protein localization
2.83 2.01e-02 GO:0032103 positive regulation of response to external stimulus
1.66 2.03e-02 GO:0001932 regulation of protein phosphorylation
3.47 2.34e-02 GO:0034339 regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor
2.73 2.35e-02 GO:0070663 regulation of leukocyte proliferation
3.17 2.50e-02 GO:0051092 positive regulation of NF-kappaB transcription factor activity
2.11 2.59e-02 GO:0003002 regionalization
1.62 3.08e-02 GO:0019220 regulation of phosphate metabolic process
1.62 3.08e-02 GO:0051174 regulation of phosphorus metabolic process
2.62 3.14e-02 GO:0090047 positive regulation of transcription regulator activity
2.02 3.77e-02 GO:0051101 regulation of DNA binding
2.72 4.03e-02 GO:0050670 regulation of lymphocyte proliferation
2.38 4.05e-02 GO:0030335 positive regulation of cell migration
2.38 4.05e-02 GO:2000147 positive regulation of cell motility
2.10 4.13e-02 GO:0032101 regulation of response to external stimulus
2.05 4.19e-02 GO:0090046 regulation of transcription regulator activity
1.71 4.60e-02 GO:0009607 response to biotic stimulus
2.33 4.72e-02 GO:0009952 anterior/posterior pattern formation
2.69 4.76e-02 GO:0032944 regulation of mononuclear cell proliferation
3.29 4.80e-02 GO:0050864 regulation of B cell activation
2.76 4.91e-02 GO:0030198 extracellular matrix organization

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.30 8.12e-12 GO:0005634 nucleus
1.11 3.81e-06 GO:0044424 intracellular part
1.10 5.96e-06 GO:0005622 intracellular
1.52 3.79e-05 GO:0005654 nucleoplasm
1.14 7.79e-05 GO:0043231 intracellular membrane-bounded organelle
1.39 9.37e-05 GO:0005829 cytosol
1.13 9.67e-05 GO:0043227 membrane-bounded organelle
1.11 1.68e-03 GO:0043229 intracellular organelle
1.11 1.81e-03 GO:0043226 organelle
1.36 2.10e-03 GO:0031981 nuclear lumen
1.57 2.38e-03 GO:0005615 extracellular space
1.32 4.54e-03 GO:0044428 nuclear part
1.30 9.85e-03 GO:0070013 intracellular organelle lumen
1.30 1.12e-02 GO:0044459 plasma membrane part
1.45 1.14e-02 GO:0044421 extracellular region part
1.29 1.29e-02 GO:0043233 organelle lumen
1.28 1.37e-02 GO:0031974 membrane-enclosed lumen
1.40 1.95e-02 GO:0005887 integral to plasma membrane
1.39 2.02e-02 GO:0031226 intrinsic to plasma membrane
3.77 3.53e-02 GO:0005581 collagen
1.73 3.72e-02 GO:0009986 cell surface
2.24 4.56e-02 GO:0009897 external side of plasma membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.30 3.75e-18 GO:0005515 protein binding
1.15 3.42e-14 GO:0005488 binding
1.93 3.35e-12 GO:0001071 nucleic acid binding transcription factor activity
1.93 3.35e-12 GO:0003700 sequence-specific DNA binding transcription factor activity
2.04 6.70e-10 GO:0043565 sequence-specific DNA binding
1.79 4.85e-09 GO:0030528 transcription regulator activity
1.36 1.27e-04 GO:0003677 DNA binding
2.40 6.79e-04 GO:0005126 cytokine receptor binding
4.32 1.08e-03 GO:0003823 antigen binding
2.00 1.19e-03 GO:0016563 transcription activator activity
1.63 1.71e-03 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.68 2.39e-03 GO:0004672 protein kinase activity
3.66 2.45e-03 GO:0004879 ligand-dependent nuclear receptor activity
1.25 4.50e-03 GO:0003676 nucleic acid binding
1.56 5.97e-03 GO:0016301 kinase activity
1.77 7.44e-03 GO:0004674 protein serine/threonine kinase activity
1.57 8.13e-03 GO:0019899 enzyme binding
1.94 8.86e-03 GO:0008134 transcription factor binding
2.10 2.57e-02 GO:0010843 promoter binding
3.39 2.58e-02 GO:0003707 steroid hormone receptor activity