Motif ID: NHLH1,2.p2

Z-value: 2.103


Transcription factors associated with NHLH1,2.p2:

Gene SymbolEntrez IDGene Name
NHLH1 4807 nescient helix loop helix 1
NHLH2 4808 nescient helix loop helix 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NHLH2chr1_-_1163836920.518.8e-16Click!
NHLH1chr1_+_1603368560.473.9e-13Click!


Activity profile for motif NHLH1,2.p2.

activity profile for motif NHLH1,2.p2


Sorted Z-values histogram for motif NHLH1,2.p2

Sorted Z-values for motif NHLH1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NHLH1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_35521591 41.904 NM_001037
NM_199037
SCN1B

sodium channel, voltage-gated, type I, beta

chr8_+_24771276 39.890 NEFM
neurofilament, medium polypeptide
chr8_+_24771268 34.605 NM_005382
NEFM
neurofilament, medium polypeptide
chr18_-_74691951 32.843 MBP
myelin basic protein
chr3_-_195306274 32.155 APOD
apolipoprotein D
chrX_-_13956530 27.148 GPM6B
glycoprotein M6B
chr14_+_100150596 26.922 NM_006668
CYP46A1
cytochrome P450, family 46, subfamily A, polypeptide 1
chr11_-_125366048 26.908 NM_005103
NM_022549
FEZ1

fasciculation and elongation protein zeta 1 (zygin I)

chr1_+_233749749 26.867 NM_002245
KCNK1
potassium channel, subfamily K, member 1
chr20_-_23618382 26.616 NM_000099
CST3
cystatin C
chr2_+_233498206 25.247 NM_025202
EFHD1
EF-hand domain family, member D1
chr6_-_159420796 25.087 RSPH3
radial spoke 3 homolog (Chlamydomonas)
chr14_-_103988829 24.141 CKB
creatine kinase, brain
chrX_-_13956644 24.096 NM_001001994
GPM6B
glycoprotein M6B
chr3_-_149688886 24.059 PFN2
profilin 2
chr16_-_57318574 23.868 NM_015993
PLLP
plasmolipin
chr1_+_77747727 23.352 AK5
adenylate kinase 5
chrX_-_13956445 23.210


chr20_+_10199455 22.741 NM_003081
NM_130811
SNAP25

synaptosomal-associated protein, 25kDa

chr16_+_58497628 22.700 NDRG4
NDRG family member 4
chrX_+_47092362 22.001 USP11
ubiquitin specific peptidase 11
chr2_+_79740059 21.854 NM_001164883
NM_004389
CTNNA2

catenin (cadherin-associated protein), alpha 2

chrX_+_47092264 21.851 NM_004651
USP11
ubiquitin specific peptidase 11
chr10_-_73611041 21.789 PSAP
prosaposin
chr6_-_84419108 21.728 NM_001242793
NM_001242794
NM_014841
SNAP91


synaptosomal-associated protein, 91kDa homolog (mouse)


chr12_+_79258517 21.484 SYT1
synaptotagmin I
chr6_-_84419018 21.346 SNAP91
synaptosomal-associated protein, 91kDa homolog (mouse)
chr16_+_50099907 21.247 HEATR3
HEAT repeat containing 3
chr10_+_104678001 21.160 NM_017649
NM_199076
NM_199077
CNNM2


cyclin M2


chr6_+_126112057 21.121 NCOA7
nuclear receptor coactivator 7
chr16_+_58497548 21.089 NM_020465
NDRG4
NDRG family member 4
chr19_-_6502224 21.086 NM_006087
TUBB4A
tubulin, beta 4A class IVa
chr17_+_7554415 21.032 ATP1B2
ATPase, Na+/K+ transporting, beta 2 polypeptide
chr7_-_137531585 20.971 NM_004717
DGKI
diacylglycerol kinase, iota
chr1_+_171810611 20.918 NM_001136127
NM_015569
DNM3

dynamin 3

chr12_+_79258588 20.663 SYT1
synaptotagmin I
chr10_-_73611005 20.511 PSAP
prosaposin
chr16_+_330605 19.905 NM_001176
ARHGDIG
Rho GDP dissociation inhibitor (GDI) gamma
chr8_+_85095452 19.669 NM_001100392
NM_001100393
RALYL

RALY RNA binding protein-like

chr1_+_233749917 18.702 KCNK1
potassium channel, subfamily K, member 1
chr1_-_57045129 18.471 PPAP2B
phosphatidic acid phosphatase type 2B
chr22_+_29876180 18.229 NM_021076
NEFH
neurofilament, heavy polypeptide
chr19_+_4304590 18.215 NM_024333
FSD1
fibronectin type III and SPRY domain containing 1
chr13_-_45150391 18.100 TSC22D1
TSC22 domain family, member 1
chr3_-_73673978 18.076 NM_015009
PDZRN3
PDZ domain containing ring finger 3
chr20_-_3154169 17.927 ProSAPiP1
ProSAPiP1 protein
chr10_-_81205091 17.820 NM_153367
ZCCHC24
zinc finger, CCHC domain containing 24
chr7_+_139877154 17.624 LOC100134229
uncharacterized LOC100134229
chr2_+_79740171 17.585 CTNNA2
catenin (cadherin-associated protein), alpha 2
chr16_+_1756161 17.486 NM_001040439
NM_015133
MAPK8IP3

mitogen-activated protein kinase 8 interacting protein 3

chr11_-_75141015 17.418 KLHL35
kelch-like 35 (Drosophila)
chr6_-_84418705 17.406 NM_001242792
SNAP91
synaptosomal-associated protein, 91kDa homolog (mouse)
chr17_-_15165860 17.302 PMP22
peripheral myelin protein 22
chr10_+_124220990 17.280 NM_002775
HTRA1
HtrA serine peptidase 1
chr3_+_167453431 17.245 NM_001122752
NM_005025
SERPINI1

serpin peptidase inhibitor, clade I (neuroserpin), member 1

chr2_+_149633173 17.059


chr10_-_73610958 16.921 PSAP
prosaposin
chr6_-_46459010 16.551 NM_001251974
RCAN2
regulator of calcineurin 2
chr19_-_49944613 16.321 NM_020309
SLC17A7
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7
chr3_-_42305438 16.222 NM_001174138
CCK
cholecystokinin
chr19_-_58609606 16.126 NM_001145543
NM_001145544
NM_023926
ZSCAN18


zinc finger and SCAN domain containing 18


chr1_+_46269283 15.948 NM_015112
MAST2
microtubule associated serine/threonine kinase 2
chr10_+_105036783 15.934 NM_032727
INA
internexin neuronal intermediate filament protein, alpha
chr17_-_79139871 15.842 NM_001080395
AATK
apoptosis-associated tyrosine kinase
chr12_-_50297575 15.717 NM_012306
FAIM2
Fas apoptotic inhibitory molecule 2
chr16_-_57318452 15.480 PLLP
plasmolipin
chr11_-_66335958 15.350 NM_003793
CTSF
cathepsin F
chr11_+_113930430 15.315 NM_006006
ZBTB16
zinc finger and BTB domain containing 16
chr5_+_113698304 15.280 KCNN2
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
chr6_+_43543921 15.195 POLH
polymerase (DNA directed), eta
chr5_-_136834887 15.111 NM_004598
SPOCK1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
chr16_+_23847271 15.040 NM_002738
NM_212535
PRKCB

protein kinase C, beta

chr3_-_120068077 14.846 NM_001099678
LRRC58
leucine rich repeat containing 58
chr14_+_93389444 14.831 NM_001275
CHGA
chromogranin A (parathyroid secretory protein 1)
chr16_+_23847321 14.767 PRKCB
protein kinase C, beta
chr12_+_79258448 14.715 NM_005639
SYT1
synaptotagmin I
chr12_+_79258794 14.682 SYT1
synaptotagmin I
chr8_+_136469557 14.478 NM_006558
KHDRBS3
KH domain containing, RNA binding, signal transduction associated 3
chrX_-_47479229 14.386 NM_006950
NM_133499
SYN1

synapsin I

chr8_-_145669796 14.372 NM_013432
TONSL
tonsoku-like, DNA repair protein
chr19_-_46974663 14.369 PNMAL1
PNMA-like 1
chr3_-_62861012 14.294 NM_003716
NM_183393
NM_183394
CADPS


Ca++-dependent secretion activator


chr19_+_3094528 14.261 GNA11
guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
chr10_-_73611050 14.208 NM_001042465
NM_001042466
NM_002778
PSAP


prosaposin


chr4_-_57976550 14.197 NM_001253835
NM_001553
IGFBP7

insulin-like growth factor binding protein 7

chr2_-_47797469 14.089 NM_022055
KCNK12
potassium channel, subfamily K, member 12
chr1_-_57044980 14.086 PPAP2B
phosphatidic acid phosphatase type 2B
chr19_+_36359346 14.026 NM_001024807
NM_005166
APLP1

amyloid beta (A4) precursor-like protein 1

chr17_+_36507708 13.968 NM_014598
SOCS7
suppressor of cytokine signaling 7
chr13_-_36705432 13.853 DCLK1
doublecortin-like kinase 1
chr4_+_7045142 13.732 NM_152293
TADA2B
transcriptional adaptor 2B
chr3_-_149688638 13.661 NM_002628
NM_053024
PFN2

profilin 2

chr14_-_21493858 13.507 NDRG2
NDRG family member 2
chr16_+_22825806 13.474 NM_006043
HS3ST2
heparan sulfate (glucosamine) 3-O-sulfotransferase 2
chr16_+_23847359 13.341 PRKCB
protein kinase C, beta
chr1_-_57045214 13.299 PPAP2B
phosphatidic acid phosphatase type 2B
chr10_-_135150474 13.250 NM_015722
CALY
calcyon neuron-specific vesicular protein
chr19_-_46974789 13.236 NM_001103149
NM_018215
PNMAL1

PNMA-like 1

chr19_+_13875345 13.189 MRI1
methylthioribose-1-phosphate isomerase homolog (S. cerevisiae)
chr6_-_29600668 13.159 GABBR1
gamma-aminobutyric acid (GABA) B receptor, 1
chr7_+_45614081 13.087 NM_021116
ADCY1
adenylate cyclase 1 (brain)
chr2_+_191745791 13.057 GLS
glutaminase
chr19_+_12949258 12.987 NM_014975
MAST1
microtubule associated serine/threonine kinase 1
chr1_+_202317798 12.916 NM_001167857
NM_001167858
NM_002481
PPP1R12B


protein phosphatase 1, regulatory subunit 12B


chr7_+_29234325 12.893 CHN2
chimerin (chimaerin) 2
chr1_+_20959946 12.877 NM_032409
PINK1
PTEN induced putative kinase 1
chr18_-_5543967 12.859 NM_012307
EPB41L3
erythrocyte membrane protein band 4.1-like 3
chr7_-_124405029 12.757 GPR37
G protein-coupled receptor 37 (endothelin receptor type B-like)
chr1_-_32229635 12.675 NM_001703
BAI2
brain-specific angiogenesis inhibitor 2
chr1_+_77747602 12.590 NM_174858
AK5
adenylate kinase 5
chr19_-_18314731 12.487 NM_002866
RAB3A
RAB3A, member RAS oncogene family
chr12_+_53443834 12.464 NM_170754
TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr17_-_27278324 12.462 PHF12
PHD finger protein 12
chr18_-_74729049 12.401 NM_001025081
NM_001025090
NM_001025092
NM_002385
MBP



myelin basic protein



chrX_-_48693934 12.334 NM_013271
PCSK1N
proprotein convertase subtilisin/kexin type 1 inhibitor
chr14_+_90863302 12.307 NM_006888
CALM1
calmodulin 1 (phosphorylase kinase, delta)
chr14_+_90863365 12.303 CALM1
calmodulin 1 (phosphorylase kinase, delta)
chr12_-_124457099 12.255 NM_025140
CCDC92
coiled-coil domain containing 92
chr17_-_56609387 12.179 NM_080415
NM_080416
SEPT4

septin 4

chr10_-_135150368 12.031 CALY
calcyon neuron-specific vesicular protein
chr4_-_57976516 12.028 IGFBP7
insulin-like growth factor binding protein 7
chr11_-_35547144 11.963 NM_001001991
NM_015430
PAMR1

peptidase domain containing associated with muscle regeneration 1

chr8_+_85095501 11.921 NM_173848
RALYL
RALY RNA binding protein-like
chr14_+_76127592 11.910 TTLL5
tubulin tyrosine ligase-like family, member 5
chr5_+_151151660 11.757 G3BP1
GTPase activating protein (SH3 domain) binding protein 1
chr2_+_236403290 11.724 AGAP1
ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
chr8_+_24772454 11.628 NM_001105541
NEFM
neurofilament, medium polypeptide
chr2_+_236402948 11.622 AGAP1
ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
chr5_+_67511578 11.543 NM_181523
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr16_+_22825481 11.514 HS3ST2
heparan sulfate (glucosamine) 3-O-sulfotransferase 2
chr2_-_55277459 11.437 RTN4
reticulon 4
chr13_-_36705513 11.433 NM_004734
DCLK1
doublecortin-like kinase 1
chr2_-_55277698 11.306 NM_020532
NM_153828
NM_207520
RTN4


reticulon 4


chr7_+_98246595 11.292 NM_002523
NPTX2
neuronal pentraxin II
chr19_+_18723666 11.286 NM_012109
TMEM59L
transmembrane protein 59-like
chrX_+_135229536 11.281 NM_001159702
NM_001159703
NM_001449
FHL1


four and a half LIM domains 1


chr11_-_6440631 11.258 NM_145689
APBB1
amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
chr4_-_5890142 11.171 CRMP1
collapsin response mediator protein 1
chr10_-_15413054 11.162 NM_001010924
FAM171A1
family with sequence similarity 171, member A1
chr14_+_93389491 11.147 CHGA
chromogranin A (parathyroid secretory protein 1)
chrX_-_140271275 11.118 LDOC1
leucine zipper, down-regulated in cancer 1
chr15_+_74833517 11.020 NM_006465
ARID3B
AT rich interactive domain 3B (BRIGHT-like)
chr14_+_29236882 10.989 FOXG1
forkhead box G1
chr12_-_120554558 10.961 RAB35
RAB35, member RAS oncogene family
chr7_-_766875 10.943 NM_001164760
PRKAR1B
protein kinase, cAMP-dependent, regulatory, type I, beta
chr11_-_78128765 10.938 GAB2
GRB2-associated binding protein 2
chr5_+_139493689 10.931 NM_005859
PURA
purine-rich element binding protein A
chr11_-_207324 10.842 BET1L
blocked early in transport 1 homolog (S. cerevisiae)-like
chr4_+_176987148 10.828 WDR17
WD repeat domain 17
chr3_+_184056304 10.696 FAM131A
family with sequence similarity 131, member A
chr1_-_40157067 10.671 NM_016257
HPCAL4
hippocalcin like 4
chr9_+_17134974 10.663 NM_001114395
NM_017738
CNTLN

centlein, centrosomal protein

chr19_-_19006868 10.610 NM_021267
NM_198207
NM_001492
CERS1

GDF1
ceramide synthase 1

growth differentiation factor 1
chr9_+_124030455 10.494 GSN
gelsolin
chr11_+_113930296 10.373 ZBTB16
zinc finger and BTB domain containing 16
chr20_+_20348744 10.338 NM_002196
INSM1
insulinoma-associated 1
chr22_-_18923654 10.292 PRODH
proline dehydrogenase (oxidase) 1
chr10_-_133795447 10.273 BNIP3
BCL2/adenovirus E1B 19kDa interacting protein 3
chr22_+_32340592 10.257 YWHAH
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide
chr15_+_75118950 10.248 NM_001030005
CPLX3
complexin 3
chr16_+_3355432 10.239 NM_153028
ZNF75A
zinc finger protein 75a
chr5_-_73936299 10.183 ENC1
ectodermal-neural cortex 1 (with BTB-like domain)
chrX_+_53111482 10.173 NM_022117
TSPYL2
TSPY-like 2
chr7_-_149321828 10.163 ZNF767
zinc finger family member 767
chr6_-_29600859 10.137 GABBR1
gamma-aminobutyric acid (GABA) B receptor, 1
chr21_+_27011588 10.132 NM_021219
JAM2
junctional adhesion molecule 2
chr11_-_207391 10.080 BET1L
blocked early in transport 1 homolog (S. cerevisiae)-like
chr18_+_21594349 10.025 NM_001135993
NM_001243425
TTC39C

tetratricopeptide repeat domain 39C

chr3_-_195310985 9.982 NM_001647
APOD
apolipoprotein D
chr18_-_74728963 9.980 MBP
myelin basic protein
chr6_-_167040700 9.948 NM_021135
RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr7_-_158622184 9.831 ESYT2
extended synaptotagmin-like protein 2
chr4_-_5890266 9.790 NM_001313
CRMP1
collapsin response mediator protein 1
chr20_+_19193364 9.740 SLC24A3
solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
chr1_-_21995793 9.736 NM_001145657
NM_002885
RAP1GAP

RAP1 GTPase activating protein

chr17_-_56609361 9.703 SEPT4
septin 4
chr16_+_31085751 9.703 ZNF646
zinc finger protein 646
chr3_-_45267068 9.645 TMEM158
transmembrane protein 158 (gene/pseudogene)
chr8_+_22462532 9.578 NM_021174
KIAA1967
KIAA1967
chr12_-_120554453 9.576 RAB35
RAB35, member RAS oncogene family
chr8_-_145669771 9.522 TONSL
tonsoku-like, DNA repair protein
chr17_+_47653474 9.484 NXPH3
neurexophilin 3
chr16_+_31085722 9.469 NM_014699
ZNF646
zinc finger protein 646
chr1_+_51701995 9.453 RNF11
ring finger protein 11
chr2_+_149632772 9.408 NM_004522
KIF5C
kinesin family member 5C
chrX_-_40506666 9.406 CXorf38
chromosome X open reading frame 38
chr3_-_133614421 9.395 NM_016577
RAB6B
RAB6B, member RAS oncogene family
chr17_+_28256873 9.349 NM_001145053
EFCAB5
EF-hand calcium binding domain 5
chr10_-_118764559 9.322 KIAA1598
KIAA1598
chr19_+_45409003 9.282 NM_000041
APOE
apolipoprotein E
chr17_-_15165873 9.282 NM_153321
PMP22
peripheral myelin protein 22
chr7_-_108166514 9.260 PNPLA8
patatin-like phospholipase domain containing 8
chr5_-_178772430 9.257 NM_014244
NM_021599
ADAMTS2

ADAM metallopeptidase with thrombospondin type 1 motif, 2

chr1_+_2005083 9.238 NM_001033581
PRKCZ
protein kinase C, zeta
chr11_-_117747331 9.226 FXYD6
FXYD domain containing ion transport regulator 6
chr6_-_29600959 9.142 NM_001470
NM_021904
GABBR1

gamma-aminobutyric acid (GABA) B receptor, 1

chr7_-_44530178 9.141 NM_015332
NUDCD3
NudC domain containing 3
chr9_-_139940595 9.133 NM_015392
NPDC1
neural proliferation, differentiation and control, 1
chr10_+_105037441 9.110 INA
internexin neuronal intermediate filament protein, alpha
chr19_+_13875299 9.088 NM_001031727
NM_032285
MRI1

methylthioribose-1-phosphate isomerase homolog (S. cerevisiae)


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.68 7.18e-27 GO:0007399 nervous system development
1.43 8.05e-27 GO:0048856 anatomical structure development
1.38 5.12e-26 GO:0023052 signaling
1.45 8.74e-26 GO:0048731 system development
1.37 5.11e-25 GO:0032502 developmental process
1.39 9.89e-25 GO:0007275 multicellular organismal development
1.21 3.83e-23 GO:0065007 biological regulation
1.36 4.02e-20 GO:0007165 signal transduction
1.20 6.75e-18 GO:0050794 regulation of cellular process
1.19 6.99e-18 GO:0050789 regulation of biological process
1.12 3.99e-17 GO:0009987 cellular process
1.53 1.99e-16 GO:0009653 anatomical structure morphogenesis
1.24 4.67e-16 GO:0032501 multicellular organismal process
1.28 1.45e-15 GO:0051716 cellular response to stimulus
1.43 2.20e-15 GO:0048869 cellular developmental process
1.70 4.60e-15 GO:0048699 generation of neurons
1.42 1.03e-14 GO:0030154 cell differentiation
1.53 2.37e-14 GO:0035556 intracellular signal transduction
1.66 2.39e-14 GO:0022008 neurogenesis
1.65 3.82e-14 GO:0048468 cell development
1.75 6.35e-14 GO:0030182 neuron differentiation
1.44 1.80e-13 GO:0007166 cell surface receptor linked signaling pathway
1.81 6.61e-13 GO:0048666 neuron development
1.86 7.60e-11 GO:0048667 cell morphogenesis involved in neuron differentiation
1.81 1.09e-10 GO:0031175 neuron projection development
1.47 1.42e-10 GO:0051239 regulation of multicellular organismal process
1.85 1.50e-10 GO:0048812 neuron projection morphogenesis
1.35 2.46e-10 GO:0065008 regulation of biological quality
1.86 2.60e-10 GO:0007409 axonogenesis
1.78 3.01e-10 GO:0007417 central nervous system development
1.79 3.02e-10 GO:0000904 cell morphogenesis involved in differentiation
1.69 3.40e-10 GO:0030030 cell projection organization
1.34 5.05e-10 GO:0042221 response to chemical stimulus
1.77 5.51e-10 GO:0048858 cell projection morphogenesis
1.37 5.73e-10 GO:0048513 organ development
1.76 1.21e-09 GO:0032990 cell part morphogenesis
1.56 2.68e-09 GO:0040011 locomotion
1.76 2.71e-09 GO:0019226 transmission of nerve impulse
1.76 2.71e-09 GO:0035637 multicellular organismal signaling
1.59 5.51e-09 GO:0007267 cell-cell signaling
1.39 6.11e-09 GO:0023051 regulation of signaling
1.67 6.47e-09 GO:0000902 cell morphogenesis
1.78 1.15e-08 GO:0007268 synaptic transmission
1.64 1.24e-08 GO:0032989 cellular component morphogenesis
1.62 1.45e-08 GO:0009719 response to endogenous stimulus
1.95 1.84e-08 GO:0019932 second-messenger-mediated signaling
1.49 2.06e-08 GO:0007154 cell communication
2.66 2.61e-08 GO:0007202 activation of phospholipase C activity
1.79 3.17e-08 GO:0016477 cell migration
2.63 4.16e-08 GO:0010863 positive regulation of phospholipase C activity
1.24 4.34e-08 GO:0051179 localization
2.32 4.42e-08 GO:0019935 cyclic-nucleotide-mediated signaling
2.58 6.11e-08 GO:0010518 positive regulation of phospholipase activity
1.50 1.08e-07 GO:0050793 regulation of developmental process
1.16 1.13e-07 GO:0050896 response to stimulus
2.51 1.33e-07 GO:0010517 regulation of phospholipase activity
1.61 2.48e-07 GO:0009725 response to hormone stimulus
1.84 2.70e-07 GO:0007411 axon guidance
1.47 3.09e-07 GO:0009605 response to external stimulus
1.54 4.60e-07 GO:2000026 regulation of multicellular organismal development
2.46 5.10e-07 GO:0019933 cAMP-mediated signaling
1.69 8.69e-07 GO:0048870 cell motility
1.69 8.69e-07 GO:0051674 localization of cell
2.42 1.13e-06 GO:0060193 positive regulation of lipase activity
1.56 1.60e-06 GO:0007167 enzyme linked receptor protein signaling pathway
1.61 1.78e-06 GO:0006928 cellular component movement
2.26 2.07e-06 GO:0007187 G-protein signaling, coupled to cyclic nucleotide second messenger
2.49 2.98e-06 GO:0045761 regulation of adenylate cyclase activity
1.27 3.12e-06 GO:0048519 negative regulation of biological process
1.65 3.90e-06 GO:0072358 cardiovascular system development
1.65 3.90e-06 GO:0072359 circulatory system development
1.77 4.79e-06 GO:0044057 regulation of system process
2.44 6.70e-06 GO:0031279 regulation of cyclase activity
2.23 7.77e-06 GO:0060191 regulation of lipase activity
1.30 8.31e-06 GO:0048583 regulation of response to stimulus
1.28 8.52e-06 GO:0048523 negative regulation of cellular process
1.43 9.02e-06 GO:0032879 regulation of localization
1.37 9.99e-06 GO:0010033 response to organic substance
1.35 1.38e-05 GO:0009966 regulation of signal transduction
2.39 1.45e-05 GO:0051339 regulation of lyase activity
2.30 1.98e-05 GO:0030817 regulation of cAMP biosynthetic process
1.77 2.38e-05 GO:0022603 regulation of anatomical structure morphogenesis
1.71 2.50e-05 GO:0007420 brain development
2.28 2.81e-05 GO:0030814 regulation of cAMP metabolic process
2.21 3.39e-05 GO:0030799 regulation of cyclic nucleotide metabolic process
2.36 3.52e-05 GO:0021700 developmental maturation
2.22 3.99e-05 GO:0030802 regulation of cyclic nucleotide biosynthetic process
2.22 3.99e-05 GO:0030808 regulation of nucleotide biosynthetic process
1.39 4.06e-05 GO:0010646 regulation of cell communication
1.44 4.20e-05 GO:0009888 tissue development
1.71 8.37e-05 GO:0043434 response to peptide hormone stimulus
2.33 8.42e-05 GO:0007188 G-protein signaling, coupled to cAMP nucleotide second messenger
2.10 9.27e-05 GO:0031644 regulation of neurological system process
2.18 1.46e-04 GO:0050890 cognition
1.22 1.59e-04 GO:0048518 positive regulation of biological process
2.23 1.74e-04 GO:0007611 learning or memory
2.18 2.82e-04 GO:0050804 regulation of synaptic transmission
1.58 3.45e-04 GO:0051094 positive regulation of developmental process
2.10 4.11e-04 GO:0051969 regulation of transmission of nerve impulse
1.46 4.42e-04 GO:0045595 regulation of cell differentiation
1.72 4.44e-04 GO:0001944 vasculature development
1.52 7.92e-04 GO:0006935 chemotaxis
1.52 7.92e-04 GO:0042330 taxis
1.72 8.06e-04 GO:0061061 muscle structure development
1.50 9.28e-04 GO:0007186 G-protein coupled receptor protein signaling pathway
1.22 9.50e-04 GO:0048522 positive regulation of cellular process
4.00 9.96e-04 GO:0042551 neuron maturation
1.55 1.03e-03 GO:0048646 anatomical structure formation involved in morphogenesis
1.70 1.11e-03 GO:0051270 regulation of cellular component movement
1.88 1.13e-03 GO:0014070 response to organic cyclic compound
1.72 1.22e-03 GO:0001568 blood vessel development
1.59 1.29e-03 GO:0007264 small GTPase mediated signal transduction
1.51 1.40e-03 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.73 1.50e-03 GO:0030334 regulation of cell migration
1.65 1.55e-03 GO:0051093 negative regulation of developmental process
1.75 1.55e-03 GO:0050767 regulation of neurogenesis
2.44 1.65e-03 GO:0050770 regulation of axonogenesis
1.70 1.69e-03 GO:0051960 regulation of nervous system development
1.19 1.74e-03 GO:0051234 establishment of localization
2.71 1.79e-03 GO:0007200 activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger
1.68 1.92e-03 GO:0040012 regulation of locomotion
2.03 2.01e-03 GO:0043627 response to estrogen stimulus
1.46 2.28e-03 GO:0009887 organ morphogenesis
1.19 2.32e-03 GO:0006810 transport
1.71 2.60e-03 GO:2000145 regulation of cell motility
1.46 2.87e-03 GO:0042060 wound healing
1.35 3.07e-03 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.64 3.36e-03 GO:0007610 behavior
1.68 3.55e-03 GO:0048545 response to steroid hormone stimulus
1.46 4.25e-03 GO:0050878 regulation of body fluid levels
1.76 5.22e-03 GO:0048514 blood vessel morphogenesis
1.49 5.95e-03 GO:0007599 hemostasis
1.49 7.09e-03 GO:0007596 blood coagulation
1.49 7.09e-03 GO:0050817 coagulation
2.56 7.18e-03 GO:0048016 inositol phosphate-mediated signaling
1.17 7.79e-03 GO:0016043 cellular component organization
1.77 7.86e-03 GO:0045664 regulation of neuron differentiation
1.61 8.66e-03 GO:0060284 regulation of cell development
1.70 8.68e-03 GO:0007507 heart development
2.51 1.10e-02 GO:0031281 positive regulation of cyclase activity
2.51 1.10e-02 GO:0045762 positive regulation of adenylate cyclase activity
1.38 1.22e-02 GO:0006468 protein phosphorylation
1.55 1.30e-02 GO:0009792 embryo development ending in birth or egg hatching
2.40 1.30e-02 GO:0043279 response to alkaloid
1.81 1.42e-02 GO:0030900 forebrain development
1.35 1.47e-02 GO:0006351 transcription, DNA-dependent
1.50 1.71e-02 GO:0046903 secretion
1.54 1.79e-02 GO:0090066 regulation of anatomical structure size
1.70 1.91e-02 GO:0048011 nerve growth factor receptor signaling pathway
1.57 1.95e-02 GO:0071495 cellular response to endogenous stimulus
1.50 2.21e-02 GO:0007243 intracellular protein kinase cascade
1.50 2.21e-02 GO:0023014 signal transduction via phosphorylation event
1.40 2.24e-02 GO:0001932 regulation of protein phosphorylation
3.98 2.29e-02 GO:0043401 steroid hormone mediated signaling pathway
1.53 2.46e-02 GO:0043009 chordate embryonic development
2.42 2.49e-02 GO:0007194 negative regulation of adenylate cyclase activity
2.42 2.49e-02 GO:0031280 negative regulation of cyclase activity
2.42 2.49e-02 GO:0051349 positive regulation of lyase activity
2.42 2.49e-02 GO:0051350 negative regulation of lyase activity
1.61 2.71e-02 GO:0035295 tube development
2.46 2.81e-02 GO:0007190 activation of adenylate cyclase activity
1.95 3.04e-02 GO:0007265 Ras protein signal transduction
1.91 3.33e-02 GO:0001763 morphogenesis of a branching structure
1.33 3.43e-02 GO:0009611 response to wounding
1.58 3.65e-02 GO:0048729 tissue morphogenesis
1.67 3.83e-02 GO:0032868 response to insulin stimulus
2.16 3.88e-02 GO:0032355 response to estradiol stimulus
1.57 3.88e-02 GO:0032870 cellular response to hormone stimulus
3.13 3.92e-02 GO:0007632 visual behavior
2.22 3.99e-02 GO:0048469 cell maturation
1.37 4.08e-02 GO:0051049 regulation of transport
1.88 4.34e-02 GO:0042391 regulation of membrane potential
1.65 4.41e-02 GO:0030168 platelet activation
1.54 4.95e-02 GO:0032535 regulation of cellular component size

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.42 3.58e-17 GO:0044459 plasma membrane part
1.58 4.90e-17 GO:0005887 integral to plasma membrane
1.57 5.09e-17 GO:0031226 intrinsic to plasma membrane
1.12 1.03e-09 GO:0005737 cytoplasm
1.77 7.90e-09 GO:0043005 neuron projection
1.07 1.06e-06 GO:0044424 intracellular part
1.18 1.56e-06 GO:0005886 plasma membrane
2.01 3.08e-06 GO:0030424 axon
1.07 3.33e-06 GO:0005622 intracellular
1.43 3.58e-06 GO:0042995 cell projection
1.17 5.92e-06 GO:0071944 cell periphery
1.64 6.95e-06 GO:0045202 synapse
1.42 4.73e-05 GO:0031982 vesicle
1.92 7.75e-05 GO:0043025 neuronal cell body
1.89 1.01e-04 GO:0044297 cell body
1.55 4.28e-04 GO:0044463 cell projection part
1.39 5.44e-04 GO:0031988 membrane-bounded vesicle
1.79 7.23e-04 GO:0030425 dendrite
1.37 1.06e-03 GO:0031410 cytoplasmic vesicle
1.53 1.70e-03 GO:0031012 extracellular matrix
1.30 2.13e-03 GO:0000267 cell fraction
1.34 3.04e-03 GO:0005626 insoluble fraction
1.37 3.48e-03 GO:0016023 cytoplasmic membrane-bounded vesicle
1.39 7.38e-03 GO:0030054 cell junction
2.14 8.66e-03 GO:0033267 axon part
1.33 8.87e-03 GO:0005624 membrane fraction
1.10 1.85e-02 GO:0044444 cytoplasmic part
1.53 2.03e-02 GO:0044456 synapse part
3.26 2.54e-02 GO:0044304 main axon

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.16 9.87e-13 GO:0005515 protein binding
1.09 1.31e-12 GO:0005488 binding
1.36 1.84e-04 GO:0001071 nucleic acid binding transcription factor activity
1.36 1.84e-04 GO:0003700 sequence-specific DNA binding transcription factor activity
1.91 4.18e-04 GO:0005085 guanyl-nucleotide exchange factor activity
1.51 4.92e-04 GO:0060589 nucleoside-triphosphatase regulator activity
1.52 5.73e-04 GO:0030695 GTPase regulator activity
1.50 2.01e-03 GO:0019904 protein domain specific binding
1.38 2.52e-03 GO:0015075 ion transmembrane transporter activity
1.22 3.14e-03 GO:0032553 ribonucleotide binding
1.22 3.14e-03 GO:0032555 purine ribonucleotide binding
1.37 3.15e-03 GO:0042802 identical protein binding
1.22 3.16e-03 GO:0017076 purine nucleotide binding
1.31 3.61e-03 GO:0022892 substrate-specific transporter activity
1.43 3.86e-03 GO:0008324 cation transmembrane transporter activity
1.38 7.20e-03 GO:0043565 sequence-specific DNA binding
1.60 9.76e-03 GO:0032403 protein complex binding
1.21 1.03e-02 GO:0035639 purine ribonucleoside triphosphate binding
1.48 1.37e-02 GO:0005216 ion channel activity
1.32 1.40e-02 GO:0022891 substrate-specific transmembrane transporter activity
1.47 1.40e-02 GO:0015267 channel activity
1.47 1.58e-02 GO:0022803 passive transmembrane transporter activity
1.47 1.65e-02 GO:0022838 substrate-specific channel activity
1.30 1.79e-02 GO:0022857 transmembrane transporter activity
1.23 2.47e-02 GO:0030554 adenyl nucleotide binding
1.22 2.76e-02 GO:0032559 adenyl ribonucleotide binding
1.80 2.82e-02 GO:0005516 calmodulin binding
1.56 2.85e-02 GO:0005261 cation channel activity
2.64 3.17e-02 GO:0008227 G-protein coupled amine receptor activity
2.91 3.46e-02 GO:0017046 peptide hormone binding
1.52 3.86e-02 GO:0022836 gated channel activity
2.34 4.54e-02 GO:0003707 steroid hormone receptor activity
1.38 4.80e-02 GO:0008092 cytoskeletal protein binding