Motif ID: NKX2-1,4.p2

Z-value: 1.160


Transcription factors associated with NKX2-1,4.p2:

Gene SymbolEntrez IDGene Name
NKX2-1 7080 NK2 homeobox 1
NKX2-4 644524 NK2 homeobox 4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NKX2-1chr14_-_369893330.229.4e-04Click!
NKX2-4chr20_-_213780460.055.1e-01Click!


Activity profile for motif NKX2-1,4.p2.

activity profile for motif NKX2-1,4.p2


Sorted Z-values histogram for motif NKX2-1,4.p2

Sorted Z-values for motif NKX2-1,4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-1,4.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_+_101846668 19.181 GRIK2
glutamate receptor, ionotropic, kainate 2
chr4_-_102268483 16.977 PPP3CA
protein phosphatase 3, catalytic subunit, alpha isozyme
chr17_-_29641087 15.551 EVI2B
ecotropic viral integration site 2B
chr17_-_29641094 13.080 NM_006495
EVI2B
ecotropic viral integration site 2B
chr19_-_40440532 12.589 NM_003890
FCGBP
Fc fragment of IgG binding protein
chrX_+_48542159 11.594 NM_000377
WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr2_-_217724781 11.366 NM_003284
TNP1
transition protein 1 (during histone to protamine replacement)
chr20_+_4702499 10.398 NM_012409
PRND
prion protein 2 (dublet)
chr4_+_102734982 10.059 NM_001083907
BANK1
B-cell scaffold protein with ankyrin repeats 1
chr22_-_36019363 10.053 NM_203377
MB
myoglobin
chr2_-_89165652 9.783


chr17_-_10452939 9.586 NM_001100112
NM_017534
MYH2

myosin, heavy chain 2, skeletal muscle, adult

chr4_-_174320616 9.353 NM_007281
SCRG1
stimulator of chondrogenesis 1
chr5_+_156820161 9.003 CYFIP2
cytoplasmic FMR1 interacting protein 2
chr14_+_39703119 8.976 NM_054024
MIA2
melanoma inhibitory activity 2
chr2_+_28615668 8.586 FOSL2
FOS-like antigen 2
chr17_-_29641068 8.447 EVI2B
ecotropic viral integration site 2B
chr1_+_152850797 8.418 NM_030663
SMCP
sperm mitochondria-associated cysteine-rich protein
chr15_-_83474805 8.306 NM_001007122
FSD2
fibronectin type III and SPRY domain containing 2
chrX_-_72434656 7.725 NAP1L2
nucleosome assembly protein 1-like 2
chr1_-_144994839 7.687 PDE4DIP
phosphodiesterase 4D interacting protein
chr22_-_29457793 7.591 NM_015370
C22orf31
chromosome 22 open reading frame 31
chr17_+_7623038 7.533 NM_020877
DNAH2
dynein, axonemal, heavy chain 2
chr2_-_192015751 7.371 STAT4
signal transducer and activator of transcription 4
chr21_-_15918635 7.223 NM_022136
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr11_+_62439134 7.201 C11orf83
chromosome 11 open reading frame 83
chr17_-_7493389 7.173 NM_006942
SOX15
SRY (sex determining region Y)-box 15
chr2_+_28615771 7.148 NM_005253
FOSL2
FOS-like antigen 2
chr1_-_59147727 7.090


chr19_-_6670598 7.086 NM_003807
NM_172014
TNFSF14

tumor necrosis factor (ligand) superfamily, member 14

chr14_-_76447445 6.986 TGFB3
transforming growth factor, beta 3
chrX_-_154563735 6.857 NM_001289
CLIC2
chloride intracellular channel 2
chr1_+_32716839 6.838 NM_005356
LCK
lymphocyte-specific protein tyrosine kinase
chr8_-_7321028 6.653 NM_016512
NM_058200
NM_058201
NM_058202
NM_058203
SPAG11B




sperm associated antigen 11B




chr18_-_60986508 6.653 NM_000633
NM_000657
BCL2

B-cell CLL/lymphoma 2

chr11_+_60223281 6.587 NM_021950
NM_152866
MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr1_-_203320249 6.563


chr12_-_53600999 6.479 NM_000889
ITGB7
integrin, beta 7
chr4_+_22694547 6.419 NM_001128432
NM_020973
GBA3

glucosidase, beta, acid 3 (cytosolic)

chrX_-_72434667 6.298 NM_021963
NAP1L2
nucleosome assembly protein 1-like 2
chr17_-_56606710 6.273 NM_004574
SEPT4
septin 4
chr2_+_143886898 6.146 NM_018460
ARHGAP15
Rho GTPase activating protein 15
chr7_-_107443631 6.012 NM_000111
SLC26A3
solute carrier family 26, member 3
chrX_+_144908927 5.908 NM_004709
CXorf1
chromosome X open reading frame 1
chr2_-_192015934 5.883 NM_003151
STAT4
signal transducer and activator of transcription 4
chr1_-_203320287 5.829 NM_002023
FMOD
fibromodulin
chr6_+_31949800 5.787 NM_001242823
NM_001252204
NM_007293
NM_001002029
LOC100293534
C4A

C4B
complement C4-B-like
complement component 4A (Rodgers blood group)

complement component 4B (Chido blood group)
chr5_-_35118223 5.756 NM_001204314
NM_001204315
NM_001204316
NM_001204317
NM_001204318
PRLR




prolactin receptor




chr17_-_34329083 5.720 NM_032965
CCL15
chemokine (C-C motif) ligand 15
chr3_+_189349215 5.614 NM_001114978
NM_001114979
NM_003722
TP63


tumor protein p63


chr1_-_160492982 5.610 NM_001184714
NM_001184715
NM_001184716
NM_052931
SLAMF6



SLAM family member 6



chr5_-_148034089 5.541 HTR4
5-hydroxytryptamine (serotonin) receptor 4
chr7_+_129847699 5.481 NM_145268
C7orf45
chromosome 7 open reading frame 45
chr5_-_148016576 5.455 NM_001040169
NM_001040172
NM_001040173
NM_199453
HTR4



5-hydroxytryptamine (serotonin) receptor 4



chr4_-_176733413 5.424 GPM6A
glycoprotein M6A
chr8_+_7705401 5.389 NM_058203
NM_001081552
SPAG11B
SPAG11A
sperm associated antigen 11B
sperm associated antigen 11A
chr19_-_55668956 5.285 NM_000363
TNNI3
troponin I type 3 (cardiac)
chr1_-_160681552 5.270 NM_001778
CD48
CD48 molecule
chr3_+_108015392 5.120 HHLA2
HERV-H LTR-associating 2
chr6_+_43266008 5.076 SLC22A7
solute carrier family 22 (organic anion transporter), member 7
chrX_-_72434623 5.035 NAP1L2
nucleosome assembly protein 1-like 2
chr12_-_9268513 5.013 A2M
alpha-2-macroglobulin
chr8_-_93115453 4.932 NM_001198633
NM_175634
RUNX1T1

runt-related transcription factor 1; translocated to, 1 (cyclin D-related)

chr2_-_192015733 4.886 STAT4
signal transducer and activator of transcription 4
chr2_-_192016293 4.870 NM_001243835
STAT4
signal transducer and activator of transcription 4
chr3_-_58563070 4.853 FAM107A
family with sequence similarity 107, member A
chr5_+_147443534 4.809 NM_001127698
NM_001127699
NM_006846
SPINK5


serine peptidase inhibitor, Kazal type 5


chr14_-_45431121 4.793 NM_017658
KLHL28
kelch-like 28 (Drosophila)
chr2_+_143886969 4.760 ARHGAP15
Rho GTPase activating protein 15
chr2_-_100758970 4.738 NM_002285
AFF3
AF4/FMR2 family, member 3
chr12_-_16758312 4.731 NM_001243611
LMO3
LIM domain only 3 (rhombotin-like 2)
chr15_+_74466171 4.724 ISLR
immunoglobulin superfamily containing leucine-rich repeat
chr11_-_102826433 4.543 NM_002427
MMP13
matrix metallopeptidase 13 (collagenase 3)
chr10_+_102222797 4.531 NM_003393
WNT8B
wingless-type MMTV integration site family, member 8B
chr17_-_56606534 4.449 SEPT4
septin 4
chr1_-_144994908 4.440 PDE4DIP
phosphodiesterase 4D interacting protein
chr12_+_50451486 4.355 NM_001095
NM_020039
ACCN2

amiloride-sensitive cation channel 2, neuronal

chr21_-_34863779 4.350 NM_017833
DNAJC28
DnaJ (Hsp40) homolog, subfamily C, member 28
chr9_-_77503009 4.326 NM_017662
TRPM6
transient receptor potential cation channel, subfamily M, member 6
chr11_-_6643809 4.309 DCHS1
dachsous 1 (Drosophila)
chr2_-_192015706 4.270 STAT4
signal transducer and activator of transcription 4
chr16_+_28943259 4.242 NM_001178098
NM_001770
CD19

CD19 molecule

chr2_+_103035148 4.238 NM_003853
IL18RAP
interleukin 18 receptor accessory protein
chr12_-_7848324 4.199 NM_020634
GDF3
growth differentiation factor 3
chr20_+_44657858 4.192 SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5
chr12_+_41086189 4.158 NM_001843
NM_175038
CNTN1

contactin 1

chr16_-_31100129 4.140 NM_001039503
PRSS53
protease, serine, 53
chr1_-_203198772 4.088 NM_003465
CHIT1
chitinase 1 (chitotriosidase)
chr10_-_75335415 4.029 NM_152586
USP54
ubiquitin specific peptidase 54
chr7_+_120629444 4.003 NM_001105533
C7orf58
chromosome 7 open reading frame 58
chr6_-_11779279 3.982 NM_001143948
NM_032744
C6orf105

chromosome 6 open reading frame 105

chrX_+_64708614 3.954 NM_001010888
ZC3H12B
zinc finger CCCH-type containing 12B
chrX_+_49178508 3.952 NM_001098406
GAGE1
GAGE4
GAGE5
GAGE6
GAGE12J
G antigen 1
G antigen 4
G antigen 5
G antigen 6
G antigen 12J
chr5_+_140186658 3.941 NM_018907
NM_031500
PCDHA4

protocadherin alpha 4

chr6_+_126240369 3.895 NM_001199622
NCOA7
nuclear receptor coactivator 7
chr11_+_62439120 3.876 NM_001085372
C11orf83
chromosome 11 open reading frame 83
chr12_-_56106061 3.855 NM_001144997
ITGA7
integrin, alpha 7
chr11_+_117947726 3.837 NM_001083947
NM_001173551
NM_001173552
NM_019894
TMPRSS4



transmembrane protease, serine 4



chrX_+_49363615 3.793 NM_001040663
NM_001468
GAGE1

G antigen 1

chr20_+_31823801 3.792 NM_001243193
NM_016583
NM_130852
BPIFA1


BPI fold containing family A, member 1


chr2_+_33701320 3.791 NM_001139488
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr17_-_46667596 3.741 HOXB3
homeobox B3
chr12_-_53601051 3.648 ITGB7
integrin, beta 7
chr5_+_140800613 3.631 PCDHGA11
protocadherin gamma subfamily A, 11
chrX_+_49160124 3.624 NM_001098413
GAGE10
G antigen 10
chr8_-_57359148 3.610 NM_001135690
PENK
proenkephalin
chr3_-_47621729 3.606 NM_001206942
NM_001206945
CSPG5

chondroitin sulfate proteoglycan 5 (neuroglycan C)

chr8_+_124194751 3.587 NM_032899
NM_207006
FAM83A

family with sequence similarity 83, member A

chrX_+_48542193 3.563 WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr3_-_187009469 3.447 NM_001031849
NM_001879
NM_139125
MASP1


mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)


chr5_-_160279045 3.426 NM_025153
ATP10B
ATPase, class V, type 10B
chr1_-_203320185 3.426 FMOD
fibromodulin
chrX_+_49334991 3.415 NM_001127199
NM_001476
NM_001477
NM_001098409
NM_001098408
NM_001098418
GAGE12D
GAGE1
GAGE4
GAGE5
GAGE6
GAGE7
GAGE12I
GAGE12G
GAGE12C
GAGE12B
GAGE12E
G antigen 12D
G antigen 1
G antigen 4
G antigen 5
G antigen 6
G antigen 7
G antigen 12I
G antigen 12G
G antigen 12C
G antigen 12B
G antigen 12E
chr9_+_124048869 3.392 GSN
gelsolin
chrX_+_49325433 3.389 NM_001127199
NM_001476
NM_001477
NM_001098409
NM_001098408
NM_001098418
GAGE12D
GAGE1
GAGE4
GAGE5
GAGE6
GAGE7
GAGE12I
GAGE12G
GAGE12C
GAGE12B
GAGE12E
G antigen 12D
G antigen 1
G antigen 4
G antigen 5
G antigen 6
G antigen 7
G antigen 12I
G antigen 12G
G antigen 12C
G antigen 12B
G antigen 12E
chr17_-_66951381 3.387 NM_007168
ABCA8
ATP-binding cassette, sub-family A (ABC1), member 8
chr5_-_58882274 3.321 NM_006203
PDE4D
phosphodiesterase 4D, cAMP-specific
chr1_-_89591685 3.312 NM_004120
GBP2
guanylate binding protein 2, interferon-inducible
chr1_+_155853546 3.303 SYT11
synaptotagmin XI
chr11_-_114466471 3.299 NM_001077639
NM_017678
FAM55D

family with sequence similarity 55, member D

chr11_-_19223516 3.289 NM_001127656
NM_003476
CSRP3

cysteine and glycine-rich protein 3 (cardiac LIM protein)

chr12_+_25205488 3.271 LRMP
lymphoid-restricted membrane protein
chr12_-_10962673 3.270 NM_023917
TAS2R9
taste receptor, type 2, member 9
chrX_+_54947228 3.269 NM_001039705
NM_016157
NM_177556
TRO


trophinin


chr2_+_113816214 3.268 NM_173170
IL36RN
interleukin 36 receptor antagonist
chrX_+_78200828 3.234 NM_014499
NM_198333
P2RY10

purinergic receptor P2Y, G-protein coupled, 10

chr2_+_28616360 3.202 FOSL2
FOS-like antigen 2
chr2_+_162272619 3.162 NM_006593
TBR1
T-box, brain, 1
chr8_-_30706532 3.141 NM_031271
TEX15
testis expressed 15
chr1_-_144994943 3.115 NM_001002812
NM_014644
NM_001002810
NM_001198834
NM_001195261
PDE4DIP




phosphodiesterase 4D interacting protein




chrX_+_49226137 3.108 NM_001472
NM_001098407
GAGE2C
GAGE2E
GAGE2D
GAGE2A
G antigen 2C
G antigen 2E
G antigen 2D
G antigen 2A
chr3_-_114102488 3.085 NM_001164342
ZBTB20
zinc finger and BTB domain containing 20
chr20_+_44657812 3.083 NM_020708
SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5
chr1_-_226926875 3.068 NM_002221
ITPKB
inositol-trisphosphate 3-kinase B
chr1_+_174417211 3.059 NM_005684
GPR52
G protein-coupled receptor 52
chr10_-_76868853 3.047 NM_001007271
NM_001007272
NM_001007273
DUSP13


dual specificity phosphatase 13


chrX_+_49197555 3.042 NM_012196
NM_001472
NM_001127200
NM_001098407
NM_001127212
GAGE8
GAGE2C
GAGE2E
GAGE12J
GAGE2D
GAGE2A
G antigen 8
G antigen 2C
G antigen 2E
G antigen 12J
G antigen 2D
G antigen 2A
chr3_+_170077410 3.041 NM_001145097
NM_001248008
SKIL

SKI-like oncogene

chr17_+_67498391 3.006 MAP2K6
mitogen-activated protein kinase kinase 6
chr11_+_118754474 2.997 NM_001716
CXCR5
chemokine (C-X-C motif) receptor 5
chr1_-_13452655 2.989 NM_001024661
NM_001099854
PRAMEF13
PRAMEF14
PRAME family member 13
PRAME family member 14
chr16_+_570731 2.930


chr11_+_89764273 2.910 NM_001195234
TRIM49L2
tripartite motif containing 49-like 2
chr20_+_42187705 2.910 SGK2
serum/glucocorticoid regulated kinase 2
chr2_+_1417232 2.861 NM_000547
NM_001206744
NM_001206745
NM_175719
TPO



thyroid peroxidase



chr6_+_73076431 2.854 NM_001168411
RIMS1
regulating synaptic membrane exocytosis 1
chr19_+_16830786 2.818 NM_001007525
NWD1
NACHT and WD repeat domain containing 1
chr21_-_46348633 2.793 NM_001127491
ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr1_+_198608136 2.785 NM_002838
NM_080921
NM_080923
PTPRC


protein tyrosine phosphatase, receptor type, C


chr1_+_158323485 2.762 NM_001042583
NM_001042584
NM_001042585
NM_001042586
NM_001042587
NM_001185107
NM_001185108
NM_001185110
NM_001185112
NM_001185113
NM_001185114
NM_001185115
NM_030893
CD1E












CD1e molecule












chr18_-_53068755 2.731 TCF4
transcription factor 4
chr1_+_117297056 2.699 NM_001767
CD2
CD2 molecule
chr7_-_37024664 2.698 NM_001039459
ELMO1
engulfment and cell motility 1
chr11_-_89541742 2.693 NM_020358
TRIM49
tripartite motif containing 49
chr3_-_18480203 2.662 NM_001131010
SATB1
SATB homeobox 1
chr6_-_32160289 2.657 GPSM3
G-protein signaling modulator 3
chr7_+_39017608 2.655 NM_001166018
NM_007252
POU6F2

POU class 6 homeobox 2

chr19_-_50316360 2.654 NM_001171937
NM_025129
FUZ

fuzzy homolog (Drosophila)

chr1_-_25256364 2.645 RUNX3
runt-related transcription factor 3
chr20_+_2276612 2.644 NM_003245
TGM3
transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase)
chr3_-_51996855 2.633 NM_033010
PCBP4
poly(rC) binding protein 4
chr7_-_15601574 2.601 NM_001004320
AGMO
alkylglycerol monooxygenase
chrX_+_41583407 2.586 NM_080817
GPR82
G protein-coupled receptor 82
chr17_+_7517263 2.583 SHBG
sex hormone-binding globulin
chr1_-_230849863 2.574 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr5_-_39270708 2.561 NM_001243093
FYB
FYN binding protein
chr2_+_1418179 2.555 NM_175721
NM_175722
TPO

thyroid peroxidase

chr16_+_72097124 2.543 NM_020995
HPR
haptoglobin-related protein
chr2_+_207406815 2.534 ADAM23
ADAM metallopeptidase domain 23
chr4_-_122302112 2.499 NM_198179
QRFPR
pyroglutamylated RFamide peptide receptor
chr11_+_65984213 2.496 PACS1
phosphofurin acidic cluster sorting protein 1
chr15_+_81517639 2.492 NM_172217
IL16
interleukin 16
chr8_-_6914251 2.485 NM_021010
DEFA5
defensin, alpha 5, Paneth cell-specific
chrX_-_137821514 2.481 NM_033642
FGF13
fibroblast growth factor 13
chr12_-_87232635 2.478 NM_013244
MGAT4C
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chrX_-_40506800 2.474 NM_144970
CXorf38
chromosome X open reading frame 38
chrX_+_49216616 2.473 NM_012196
NM_001472
NM_001474
NM_001475
NM_021123
NM_001477
NM_001127200
NM_001127212
GAGE8
GAGE1
GAGE2C
GAGE4
GAGE5
GAGE6
GAGE7
GAGE12I
GAGE2E
GAGE12B
GAGE2A
G antigen 8
G antigen 1
G antigen 2C
G antigen 4
G antigen 5
G antigen 6
G antigen 7
G antigen 12I
G antigen 2E
G antigen 12B
G antigen 2A
chr12_-_9268475 2.415 A2M
alpha-2-macroglobulin
chrX_+_49207115 2.401 NM_012196
NM_001472
NM_001127200
NM_001098407
NM_001127212
GAGE8
GAGE2C
GAGE2E
GAGE2D
GAGE2A
G antigen 8
G antigen 2C
G antigen 2E
G antigen 2D
G antigen 2A
chr6_+_42018250 2.389 NM_138572
TAF8
TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa
chr4_+_71263598 2.375 NM_021225
PROL1
proline rich, lacrimal 1
chr10_+_70980058 2.375 NM_025130
HKDC1
hexokinase domain containing 1
chr12_+_49688908 2.370 NM_006262
PRPH
peripherin
chr7_+_94539209 2.332 NM_001166161
NM_001166162
NM_001166163
PPP1R9A


protein phosphatase 1, regulatory subunit 9A


chr3_+_46411632 2.326 NM_000579
NM_001100168
CCR5

chemokine (C-C motif) receptor 5

chr4_+_72204769 2.296 NM_003759
SLC4A4
solute carrier family 4, sodium bicarbonate cotransporter, member 4
chrX_-_54069593 2.272 NM_001184898
PHF8
PHD finger protein 8
chr17_+_7960201 2.243


chr17_-_56406120 2.238 NM_004758
NM_024418
BZRAP1

benzodiazapine receptor (peripheral) associated protein 1

chr17_-_63822660 2.228 NM_001037325
CEP112
centrosomal protein 112kDa
chr19_+_50706868 2.213 NM_001077186
NM_001145809
NM_024729
MYH14


myosin, heavy chain 14, non-muscle


chr18_+_6834431 2.211 NM_001010000
ARHGAP28
Rho GTPase activating protein 28
chr7_-_8302141 2.192 NM_004968
ICA1
islet cell autoantigen 1, 69kDa
chr1_+_152974222 2.191 NM_001097589
NM_005416
SPRR3

small proline-rich protein 3

chr12_-_52886971 2.168 NM_005554
KRT6A
keratin 6A
chr10_+_86131546 2.168 FAM190B
family with sequence similarity 190, member B
chr1_-_9129620 2.160 SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr2_+_170366211 2.154 NM_006063
KBTBD10
kelch repeat and BTB (POZ) domain containing 10
chr1_-_217250230 2.148 NM_001243507
NM_001243509
ESRRG

estrogen-related receptor gamma

chr10_-_11574273 2.141 NM_001080491
USP6NL
USP6 N-terminal like

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.68 1.02e-10 GO:0002376 immune system process
3.00 2.91e-08 GO:0006955 immune response
3.24 2.06e-05 GO:0050776 regulation of immune response
2.68 4.19e-05 GO:0002682 regulation of immune system process
1.38 2.00e-04 GO:0050896 response to stimulus
1.43 2.22e-04 GO:0032501 multicellular organismal process
1.52 6.93e-04 GO:0023052 signaling
1.75 8.00e-04 GO:0065008 regulation of biological quality
2.35 8.49e-04 GO:0006952 defense response
4.09 1.28e-03 GO:0046649 lymphocyte activation
3.67 1.50e-03 GO:0045321 leukocyte activation
1.61 1.63e-03 GO:0048731 system development
1.79 1.68e-03 GO:0048513 organ development
2.74 1.97e-03 GO:0001775 cell activation
5.07 2.24e-03 GO:0042110 T cell activation
2.83 2.49e-03 GO:0002684 positive regulation of immune system process
1.56 2.60e-03 GO:0048856 anatomical structure development
3.55 8.81e-03 GO:0002253 activation of immune response
1.25 1.37e-02 GO:0065007 biological regulation
3.12 1.66e-02 GO:0050778 positive regulation of immune response
1.44 2.22e-02 GO:0032502 developmental process
1.47 2.40e-02 GO:0007275 multicellular organismal development
1.46 3.31e-02 GO:0007165 signal transduction
5.56 4.36e-02 GO:0042113 B cell activation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.17 3.06e-11 GO:0005576 extracellular region
2.87 7.43e-09 GO:0005615 extracellular space
2.57 9.93e-09 GO:0044421 extracellular region part
1.70 2.21e-04 GO:0044459 plasma membrane part
1.92 1.08e-03 GO:0005887 integral to plasma membrane
1.41 1.64e-03 GO:0071944 cell periphery
1.89 1.81e-03 GO:0031226 intrinsic to plasma membrane
1.40 3.69e-03 GO:0005886 plasma membrane
3.23 4.21e-03 GO:0005792 microsome
3.12 6.47e-03 GO:0042598 vesicular fraction

Gene overrepresentation in function category:

enrichment   p-value GO term description
29.63 1.06e-03 GO:0030492 hemoglobin binding
4.04 2.83e-03 GO:0030414 peptidase inhibitor activity
3.92 4.09e-03 GO:0008083 growth factor activity
22.22 4.78e-03 GO:0019864 IgG binding
3.96 7.35e-03 GO:0004866 endopeptidase inhibitor activity
3.80 1.12e-02 GO:0061135 endopeptidase regulator activity
3.38 2.07e-02 GO:0061134 peptidase regulator activity
1.87 2.92e-02 GO:0005102 receptor binding
1.90 3.18e-02 GO:0030234 enzyme regulator activity
3.21 3.65e-02 GO:0005125 cytokine activity
2.78 4.19e-02 GO:0004857 enzyme inhibitor activity