Motif ID: NKX3-2.p2

Z-value: 1.637


Transcription factors associated with NKX3-2.p2:

Gene SymbolEntrez IDGene Name
NKX3-2 579 NK3 homeobox 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NKX3-2chr4_-_13546037-0.304.8e-06Click!


Activity profile for motif NKX3-2.p2.

activity profile for motif NKX3-2.p2


Sorted Z-values histogram for motif NKX3-2.p2

Sorted Z-values for motif NKX3-2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX3-2.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_+_118604417 28.923 NM_001077654
TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr5_+_118604504 27.750 TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr16_-_88717395 22.537 NM_000101
CYBA
cytochrome b-245, alpha polypeptide
chr14_-_107179043 21.679 IGHA1
immunoglobulin heavy constant alpha 1
chr6_-_32497925 20.051 NM_002125
HLA-DRB5
major histocompatibility complex, class II, DR beta 5
chr13_+_31287614 16.859 NM_001204406
ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr5_-_149792370 16.442 NM_001025158
NM_001025159
NM_004355
CD74


CD74 molecule, major histocompatibility complex, class II invariant chain


chrX_-_47518539 15.608 NM_004182
NM_153477
UXT

ubiquitously-expressed, prefoldin-like chaperone

chr3_+_69134057 14.757 NM_006407
ARL6IP5
ADP-ribosylation-like factor 6 interacting protein 5
chr7_-_26232148 14.448 HNRNPA2B1
heterogeneous nuclear ribonucleoprotein A2/B1
chr16_-_28222700 13.727 XPO6
exportin 6
chr6_+_32407618 13.457 NM_019111
HLA-DRA
major histocompatibility complex, class II, DR alpha
chr20_-_34330093 13.183 RBM39
RNA binding motif protein 39
chr16_-_4896197 13.049 GLYR1
glyoxylate reductase 1 homolog (Arabidopsis)
chr13_+_31309644 13.018 NM_001629
ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr1_-_31230594 12.997 LAPTM5
lysosomal protein transmembrane 5
chr6_+_29974352 12.922 HLA-J
major histocompatibility complex, class I, J (pseudogene)
chr10_-_75193297 12.686 NM_001024593
ZMYND17
zinc finger, MYND-type containing 17
chr10_+_11047253 12.484 NM_001025077
CELF2
CUGBP, Elav-like family member 2
chr6_-_31550065 12.154 NM_002341
NM_009588
LTB

lymphotoxin beta (TNF superfamily, member 3)

chrX_-_47518487 12.009 UXT
ubiquitously-expressed, prefoldin-like chaperone
chr6_-_86352650 11.984 SYNCRIP
synaptotagmin binding, cytoplasmic RNA interacting protein
chr1_-_111743261 11.453 NM_024901
DENND2D
DENN/MADD domain containing 2D
chr12_-_46662709 11.423 SLC38A1
solute carrier family 38, member 1
chr14_-_106471439 11.041 IGHA1
IGHG1
IGHM
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant mu
chr4_-_83351294 11.026 NM_001207000
NM_031372
HNRPDL

heterogeneous nuclear ribonucleoprotein D-like

chr1_-_153363544 11.018 NM_002964
S100A8
S100 calcium binding protein A8
chr3_-_121379757 10.902 NM_005335
HCLS1
hematopoietic cell-specific Lyn substrate 1
chr6_-_32557431 10.831 NM_001243965
NM_002124
HLA-DRB1

HLA-DRB4
HLA-DRB5
major histocompatibility complex, class II, DR beta 1

major histocompatibility complex, class II, DR beta 4
major histocompatibility complex, class II, DR beta 5
chr6_+_29855506 10.755


chr20_-_34330179 10.710 NM_001242599
NM_001242600
NM_004902
NM_184234
RBM39



RNA binding motif protein 39



chr17_-_38721701 10.682 NM_001838
CCR7
chemokine (C-C motif) receptor 7
chr20_-_34330177 10.660 RBM39
RNA binding motif protein 39
chr12_-_46662779 10.624 SLC38A1
solute carrier family 38, member 1
chr11_+_117857123 10.611 IL10RA
interleukin 10 receptor, alpha
chr8_+_123793894 10.557 NM_014943
ZHX2
zinc fingers and homeoboxes 2
chr3_-_121379701 10.512 HCLS1
hematopoietic cell-specific Lyn substrate 1
chr11_+_60223281 10.491 NM_021950
NM_152866
MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr5_-_150467220 10.489 NM_001252390
TNIP1
TNFAIP3 interacting protein 1
chr8_+_123793988 10.473 ZHX2
zinc fingers and homeoboxes 2
chr11_+_117857062 10.297 NM_001558
IL10RA
interleukin 10 receptor, alpha
chr8_+_123794043 10.193 ZHX2
zinc fingers and homeoboxes 2
chr5_-_149792276 10.151 CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chr6_-_31324898 10.145 HLA-B
major histocompatibility complex, class I, B
chr11_-_102323353 10.068 NM_052932
TMEM123
transmembrane protein 123
chr10_+_11047274 10.045 CELF2
CUGBP, Elav-like family member 2
chr13_-_46756295 9.866 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr12_-_92539614 9.776 NM_001731
BTG1
B-cell translocation gene 1, anti-proliferative
chr16_+_30075530 9.762 NM_184043
ALDOA
aldolase A, fructose-bisphosphate
chr13_-_46756326 9.728 NM_002298
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr6_-_31324955 9.655 HLA-B
major histocompatibility complex, class I, B
chr16_-_11680756 9.634 NM_001136472
NM_001136473
LITAF

lipopolysaccharide-induced TNF factor

chr2_+_85804613 9.580 NM_003761
VAMP8
vesicle-associated membrane protein 8 (endobrevin)
chr1_+_26606212 9.496 NM_031286
SH3BGRL3
SH3 domain binding glutamic acid-rich protein like 3
chr19_+_41284068 9.379 NM_016154
RAB4B
RAB4B, member RAS oncogene family
chr16_+_30075440 9.204 ALDOA
aldolase A, fructose-bisphosphate
chr5_-_150466696 9.199 NM_001252391
NM_001252392
TNIP1

TNFAIP3 interacting protein 1

chr1_+_40735749 9.185 ZMPSTE24
zinc metallopeptidase (STE24 homolog, S. cerevisiae)
chr6_-_30712294 9.155 NM_003897
IER3
immediate early response 3
chr1_-_111743297 9.133 DENND2D
DENN/MADD domain containing 2D
chrX_+_131157635 9.090 NM_001042452
MST4
serine/threonine protein kinase MST4
chr2_+_219081864 9.006 NM_152862
ARPC2
actin related protein 2/3 complex, subunit 2, 34kDa
chr3_-_146262421 8.982 NM_021105
PLSCR1
phospholipid scramblase 1
chr3_-_81810618 8.902 GBE1
glucan (1,4-alpha-), branching enzyme 1
chr11_-_111249902 8.900 POU2AF1
POU class 2 associating factor 1
chr6_-_31324975 8.812 NM_005514
HLA-B
major histocompatibility complex, class I, B
chr8_-_117768032 8.790 EIF3H
eukaryotic translation initiation factor 3, subunit H
chr3_-_146262320 8.788 PLSCR1
phospholipid scramblase 1
chr1_+_26644458 8.607 CD52
CD52 molecule
chr1_-_25256767 8.591 NM_004350
RUNX3
runt-related transcription factor 3
chr2_+_219082119 8.556 NM_005731
ARPC2
actin related protein 2/3 complex, subunit 2, 34kDa
chr17_-_29648631 8.452 NM_001003927
NM_014210
EVI2A

ecotropic viral integration site 2A

chr2_+_85804724 8.438 VAMP8
vesicle-associated membrane protein 8 (endobrevin)
chr14_-_106733392 8.252 IGHG1
IGHG3
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
chr2_+_219081914 8.202 ARPC2
actin related protein 2/3 complex, subunit 2, 34kDa
chr10_+_11060105 8.161 CELF2
CUGBP, Elav-like family member 2
chr1_-_225616556 7.975 NM_194442
LBR
lamin B receptor
chr6_-_86352564 7.959 NM_001159674
NM_001253771
SYNCRIP

synaptotagmin binding, cytoplasmic RNA interacting protein

chr17_-_4851688 7.922 PFN1
profilin 1
chr18_-_51690988 7.918 MBD2
methyl-CpG binding domain protein 2
chr1_-_25291474 7.830 NM_001031680
RUNX3
runt-related transcription factor 3
chr7_-_102212967 7.789 POLR2J2
POLR2J3
polymerase (RNA) II (DNA directed) polypeptide J2
polymerase (RNA) II (DNA directed) polypeptide J3
chr2_-_152146373 7.770 NM_004688
NMI
N-myc (and STAT) interactor
chrX_+_131157231 7.603 NM_001042453
NM_016542
MST4

serine/threonine protein kinase MST4

chr19_+_49838673 7.587 NM_001040031
NM_001774
CD37

CD37 molecule

chr5_-_88119604 7.552 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr17_-_4851827 7.510 PFN1
profilin 1
chr1_-_154578775 7.473 NM_001193495
ADAR
adenosine deaminase, RNA-specific
chrX_+_70765479 7.433 OGT
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
chr1_-_154600383 7.343 ADAR
adenosine deaminase, RNA-specific
chr7_+_26403944 7.340 NM_001199838
SNX10
sorting nexin 10
chr1_-_27226928 7.335 GPATCH3
G patch domain containing 3
chr19_+_36705979 7.299 ZNF146
zinc finger protein 146
chr7_-_37488408 7.277 ELMO1
engulfment and cell motility 1
chr1_-_159895279 7.265 NM_003564
TAGLN2
transgelin 2
chr7_+_5013618 7.264 RNF216P1
ring finger protein 216 pseudogene 1
chr15_+_66694216 7.212 MAP2K1
mitogen-activated protein kinase kinase 1
chr17_-_4851797 7.206 NM_005022
PFN1
profilin 1
chr14_-_106539099 7.173 IGHA1
IGHG1
IGHG3
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
chr3_-_81810914 7.143 NM_000158
GBE1
glucan (1,4-alpha-), branching enzyme 1
chr13_+_53216564 7.116 HNRNPA1L2
heterogeneous nuclear ribonucleoprotein A1-like 2
chr14_+_23235730 7.110 NM_005015
OXA1L
oxidase (cytochrome c) assembly 1-like
chr5_-_134734796 7.077 H2AFY
H2A histone family, member Y
chr6_+_32605182 7.032 NM_002122
HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
chr14_-_24616429 7.005 PSME2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr10_-_27057776 6.998 ABI1
abl-interactor 1
chr6_-_86352635 6.954 NM_001159673
SYNCRIP
synaptotagmin binding, cytoplasmic RNA interacting protein
chr21_-_46340821 6.925 ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr8_+_41348067 6.873 NM_001174124
NM_016099
GOLGA7

golgin A7

chrX_+_123234462 6.847 STAG2
stromal antigen 2
chr21_-_46340776 6.820 ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr8_+_41348126 6.743 NM_001002296
GOLGA7
golgin A7
chr1_+_26856252 6.742 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr2_-_152146133 6.697 NMI
N-myc (and STAT) interactor
chr12_+_69742130 6.656 NM_000239
LYZ
lysozyme
chr8_+_41348094 6.638 GOLGA7
golgin A7
chr11_-_111250156 6.623 NM_006235
POU2AF1
POU class 2 associating factor 1
chr16_+_30075715 6.614 NM_001127617
ALDOA
aldolase A, fructose-bisphosphate
chr8_+_41348105 6.563 GOLGA7
golgin A7
chr16_-_46723024 6.546 VPS35
vacuolar protein sorting 35 homolog (S. cerevisiae)
chr19_+_49838700 6.499 CD37
CD37 molecule
chr19_+_49838646 6.499 CD37
CD37 molecule
chr7_+_98972351 6.486 ARPC1B
actin related protein 2/3 complex, subunit 1B, 41kDa
chr1_-_159895258 6.484 TAGLN2
transgelin 2
chr10_+_11060069 6.465 CELF2
CUGBP, Elav-like family member 2
chr6_-_32634287 6.463 NM_001243961
NM_002123
HLA-DQB1

major histocompatibility complex, class II, DQ beta 1

chr1_+_24286300 6.463 NM_017761
PNRC2
proline-rich nuclear receptor coactivator 2
chr19_-_8642309 6.449 NM_012335
MYO1F
myosin IF
chrX_+_13707236 6.422 NM_001195328
NM_004251
RAB9A

RAB9A, member RAS oncogene family

chr14_-_106877689 6.374 IGHV4-31
IGH@
IGHA1
IGHA2
IGHG1
IGHG4
IGHM
immunoglobulin heavy variable 4-31
immunoglobulin heavy locus
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant alpha 2 (A2m marker)
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 4 (G4m marker)
immunoglobulin heavy constant mu
chr22_+_43547558 6.370 TSPO
translocator protein (18kDa)
chr2_+_68592432 6.360 PLEK
pleckstrin
chr1_+_211519705 6.324 NM_145759
TRAF5
TNF receptor-associated factor 5
chrX_-_153602998 6.306 NM_001110556
NM_001456
FLNA

filamin A, alpha

chr1_-_245025958 6.289 HNRNPU
heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
chr22_+_22569155 6.273


chr1_+_32687970 6.273 NM_003757
EIF3I
eukaryotic translation initiation factor 3, subunit I
chr12_-_49318663 6.264 NM_001143781
FKBP11
FK506 binding protein 11, 19 kDa
chr12_+_25205180 6.263 NM_001204126
NM_001204127
NM_006152
LRMP


lymphoid-restricted membrane protein


chr6_-_32821743 6.258 NM_000593
TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr1_-_154600446 6.248 NM_001025107
ADAR
adenosine deaminase, RNA-specific
chr1_-_235292206 6.189 NM_014765
TOMM20
translocase of outer mitochondrial membrane 20 homolog (yeast)
chr19_+_49838734 6.176 CD37
CD37 molecule
chr16_-_28223161 6.172 NM_015171
XPO6
exportin 6
chr10_-_121296044 6.169 NM_002925
RGS10
regulator of G-protein signaling 10
chr6_-_86352982 6.143 NM_001159677
NM_006372
SYNCRIP

synaptotagmin binding, cytoplasmic RNA interacting protein

chr11_+_1889902 6.141 NM_001013253
LSP1
lymphocyte-specific protein 1
chr10_-_120938276 6.114 PRDX3
peroxiredoxin 3
chr12_-_46662533 6.102 SLC38A1
solute carrier family 38, member 1
chr14_+_105953531 6.087 CRIP1
cysteine-rich protein 1 (intestinal)
chr22_+_37257004 6.085 NM_000631
NM_013416
NCF4

neutrophil cytosolic factor 4, 40kDa

chr1_+_24286311 6.077 PNRC2
proline-rich nuclear receptor coactivator 2
chr8_-_101962767 6.073 NM_001135702
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr10_-_98031154 6.009 NM_001114094
NM_013314
BLNK

B-cell linker

chr6_-_32812711 6.001 NM_004159
PSMB8
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
chr15_+_77287738 5.965 PSTPIP1
proline-serine-threonine phosphatase interacting protein 1
chr20_-_34329872 5.961 RBM39
RNA binding motif protein 39
chr7_-_87849341 5.951 SRI
sorcin
chr10_-_81965332 5.944 ANXA11
annexin A11
chr4_-_83350829 5.933 HNRPDL
heterogeneous nuclear ribonucleoprotein D-like
chr3_-_146262277 5.923 PLSCR1
phospholipid scramblase 1
chr3_+_121774208 5.920 NM_001206924
NM_001206925
NM_175862
CD86


CD86 molecule


chr3_+_50126340 5.920 NM_005778
RBM5
RNA binding motif protein 5
chr1_+_26644380 5.915 NM_001803
CD52
CD52 molecule
chr8_-_134072404 5.901 NM_006748
SLA
Src-like-adaptor
chr9_+_112542496 5.866 NM_053016
NM_007203
NM_147150
PALM2
PALM2-AKAP2

paralemmin 2
PALM2-AKAP2 readthrough

chr10_-_81965113 5.846 ANXA11
annexin A11
chr1_+_112162397 5.807 NM_001010935
NM_002884
RAP1A

RAP1A, member of RAS oncogene family

chr13_+_31309690 5.799 ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr19_-_8642297 5.765 MYO1F
myosin IF
chr9_-_137809710 5.756 NM_002003
FCN1
ficolin (collagen/fibrinogen domain containing) 1
chr15_+_44038483 5.724 NM_005313
PDIA3
protein disulfide isomerase family A, member 3
chr5_+_177631496 5.709 NM_004499
NM_031266
HNRNPAB

heterogeneous nuclear ribonucleoprotein A/B

chrX_+_128913897 5.707 SASH3
SAM and SH3 domain containing 3
chr9_+_77703395 5.697 NM_012383
OSTF1
osteoclast stimulating factor 1
chr14_+_70233862 5.686 SRSF5
serine/arginine-rich splicing factor 5
chr1_+_110091218 5.680 GNAI3
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
chr2_+_219081898 5.672 ARPC2
actin related protein 2/3 complex, subunit 2, 34kDa
chrX_+_128913881 5.598 NM_018990
SASH3
SAM and SH3 domain containing 3
chr17_-_29641094 5.597 NM_006495
EVI2B
ecotropic viral integration site 2B
chr7_+_98972326 5.584 ARPC1B
actin related protein 2/3 complex, subunit 1B, 41kDa
chr17_-_76128487 5.581 NM_007267
TMC6
transmembrane channel-like 6
chr3_-_107809754 5.567 NM_001777
NM_198793
CD47

CD47 molecule

chr10_+_11059854 5.563 NM_006561
CELF2
CUGBP, Elav-like family member 2
chr14_+_67656109 5.552 NM_173526
FAM71D
family with sequence similarity 71, member D
chr1_+_24018293 5.548 RPL11
ribosomal protein L11
chr1_-_32385258 5.533 NM_001195100
NM_001195101
PTP4A2

protein tyrosine phosphatase type IVA, member 2

chr1_+_53480573 5.517 NM_001007099
NM_001007100
NM_001007250
SCP2


sterol carrier protein 2


chr1_+_53480616 5.482 SCP2
sterol carrier protein 2
chr20_+_3869593 5.470 NM_153638
PANK2
pantothenate kinase 2
chr11_+_5710926 5.470 TRIM22
tripartite motif containing 22
chr1_+_153330329 5.468 NM_002965
S100A9
S100 calcium binding protein A9
chr2_-_158731622 5.460 NM_001105
ACVR1
activin A receptor, type I
chr2_-_145277879 5.444 NM_001171653
NM_014795
ZEB2

zinc finger E-box binding homeobox 2

chr1_+_32688010 5.429 EIF3I
eukaryotic translation initiation factor 3, subunit I
chr12_+_54891539 5.428 NCKAP1L
NCK-associated protein 1-like
chr12_-_110888079 5.422 ARPC3
actin related protein 2/3 complex, subunit 3, 21kDa
chr1_+_26856240 5.401 NM_002953
RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr20_+_57464156 5.400 GNAS
GNAS complex locus
chr15_+_44038649 5.386 PDIA3
protein disulfide isomerase family A, member 3

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.23 5.15e-39 GO:0009987 cellular process
1.51 2.79e-29 GO:0044260 cellular macromolecule metabolic process
1.37 1.52e-26 GO:0044237 cellular metabolic process
1.43 2.06e-25 GO:0043170 macromolecule metabolic process
1.35 2.63e-24 GO:0044238 primary metabolic process
1.31 1.36e-23 GO:0008152 metabolic process
1.56 1.43e-18 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.73 3.60e-18 GO:0016070 RNA metabolic process
1.61 4.12e-17 GO:0090304 nucleic acid metabolic process
1.67 1.96e-16 GO:0010467 gene expression
1.45 1.48e-14 GO:0034641 cellular nitrogen compound metabolic process
1.44 2.25e-14 GO:0006807 nitrogen compound metabolic process
1.52 3.58e-14 GO:0044267 cellular protein metabolic process
1.76 4.62e-13 GO:0002376 immune system process
2.19 1.70e-12 GO:0016071 mRNA metabolic process
1.61 6.25e-12 GO:0034645 cellular macromolecule biosynthetic process
1.60 1.45e-11 GO:0009059 macromolecule biosynthetic process
1.86 3.19e-11 GO:0008219 cell death
1.85 4.98e-11 GO:0016265 death
1.41 1.05e-10 GO:0019538 protein metabolic process
1.46 1.44e-10 GO:0044249 cellular biosynthetic process
1.37 2.36e-10 GO:0071840 cellular component organization or biogenesis
1.43 2.44e-10 GO:0048518 positive regulation of biological process
1.21 8.21e-10 GO:0050789 regulation of biological process
1.36 1.04e-09 GO:0016043 cellular component organization
1.89 1.45e-09 GO:0012501 programmed cell death
1.89 2.25e-09 GO:0006915 apoptosis
1.42 4.37e-09 GO:0009058 biosynthetic process
2.85 7.05e-09 GO:0002757 immune response-activating signal transduction
1.18 1.18e-08 GO:0065007 biological regulation
1.42 1.44e-08 GO:0006950 response to stress
2.78 1.86e-08 GO:0002764 immune response-regulating signaling pathway
2.09 2.54e-08 GO:0050776 regulation of immune response
1.39 2.76e-08 GO:0071841 cellular component organization or biogenesis at cellular level
1.85 3.57e-08 GO:0002682 regulation of immune system process
1.78 5.09e-08 GO:0046907 intracellular transport
1.39 5.81e-08 GO:0071842 cellular component organization at cellular level
1.79 8.11e-08 GO:0006955 immune response
1.19 1.23e-07 GO:0050794 regulation of cellular process
1.74 1.25e-07 GO:0043933 macromolecular complex subunit organization
2.09 1.67e-07 GO:0016032 viral reproduction
1.98 2.50e-07 GO:0034621 cellular macromolecular complex subunit organization
1.39 4.53e-07 GO:0048522 positive regulation of cellular process
2.47 4.96e-07 GO:0002253 activation of immune response
1.82 7.33e-07 GO:0006396 RNA processing
1.56 9.67e-07 GO:0051641 cellular localization
1.30 1.25e-06 GO:0051179 localization
1.48 1.40e-06 GO:0006996 organelle organization
2.05 1.78e-06 GO:0006397 mRNA processing
1.64 1.91e-06 GO:0032774 RNA biosynthetic process
1.58 2.63e-06 GO:0051649 establishment of localization in cell
1.61 2.95e-06 GO:0032268 regulation of cellular protein metabolic process
2.49 3.48e-06 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
2.49 3.48e-06 GO:0000398 nuclear mRNA splicing, via spliceosome
3.12 3.95e-06 GO:0002429 immune response-activating cell surface receptor signaling pathway
2.16 4.41e-06 GO:0006412 translation
1.59 4.97e-06 GO:0010941 regulation of cell death
1.59 5.05e-06 GO:0043067 regulation of programmed cell death
2.05 6.65e-06 GO:0044419 interspecies interaction between organisms
2.15 7.29e-06 GO:0008380 RNA splicing
2.42 9.04e-06 GO:0000375 RNA splicing, via transesterification reactions
1.25 1.15e-05 GO:0051716 cellular response to stimulus
3.00 1.20e-05 GO:0002768 immune response-regulating cell surface receptor signaling pathway
1.56 1.36e-05 GO:0051246 regulation of protein metabolic process
1.72 1.51e-05 GO:0065003 macromolecular complex assembly
1.58 1.56e-05 GO:0042981 regulation of apoptosis
1.40 1.76e-05 GO:0043412 macromolecule modification
2.15 1.80e-05 GO:0050778 positive regulation of immune response
1.78 2.15e-05 GO:0071822 protein complex subunit organization
2.83 2.26e-05 GO:0050657 nucleic acid transport
2.83 2.26e-05 GO:0050658 RNA transport
2.83 2.26e-05 GO:0051236 establishment of RNA localization
1.76 2.51e-05 GO:0009057 macromolecule catabolic process
1.40 4.52e-05 GO:0006464 protein modification process
1.48 5.31e-05 GO:0033036 macromolecule localization
2.74 5.85e-05 GO:0006403 RNA localization
1.56 6.18e-05 GO:0007049 cell cycle
1.27 6.87e-05 GO:0007165 signal transduction
1.87 7.08e-05 GO:0002684 positive regulation of immune system process
1.25 8.03e-05 GO:0019222 regulation of metabolic process
1.34 8.27e-05 GO:0048519 negative regulation of biological process
1.99 9.24e-05 GO:0018193 peptidyl-amino acid modification
1.27 1.08e-04 GO:0060255 regulation of macromolecule metabolic process
1.96 1.13e-04 GO:0034622 cellular macromolecular complex assembly
1.62 1.14e-04 GO:0006952 defense response
1.74 1.20e-04 GO:0000278 mitotic cell cycle
2.98 1.27e-04 GO:0050851 antigen receptor-mediated signaling pathway
1.60 1.76e-04 GO:0033554 cellular response to stress
1.70 1.88e-04 GO:0051726 regulation of cell cycle
2.33 1.91e-04 GO:0022411 cellular component disassembly
2.33 1.91e-04 GO:0071845 cellular component disassembly at cellular level
1.37 2.83e-04 GO:0048583 regulation of response to stimulus
2.00 3.56e-04 GO:0051325 interphase
1.48 3.58e-04 GO:0044085 cellular component biogenesis
2.74 3.69e-04 GO:0051028 mRNA transport
2.51 4.35e-04 GO:0015931 nucleobase, nucleoside, nucleotide and nucleic acid transport
2.00 4.39e-04 GO:0051329 interphase of mitotic cell cycle
1.51 4.60e-04 GO:0022607 cellular component assembly
1.43 4.65e-04 GO:0009056 catabolic process
1.56 5.49e-04 GO:0006351 transcription, DNA-dependent
1.58 8.12e-04 GO:0031399 regulation of protein modification process
1.23 9.37e-04 GO:0023052 signaling
1.72 9.48e-04 GO:0044265 cellular macromolecule catabolic process
1.98 1.12e-03 GO:0006366 transcription from RNA polymerase II promoter
2.95 1.33e-03 GO:0022618 ribonucleoprotein complex assembly
1.26 1.48e-03 GO:0051234 establishment of localization
1.27 1.68e-03 GO:0006810 transport
1.99 1.85e-03 GO:0010608 posttranscriptional regulation of gene expression
1.55 1.96e-03 GO:0022402 cell cycle process
2.25 2.18e-03 GO:0006913 nucleocytoplasmic transport
1.41 2.62e-03 GO:0035556 intracellular signal transduction
2.22 3.00e-03 GO:0051169 nuclear transport
3.82 3.35e-03 GO:0006413 translational initiation
2.08 3.40e-03 GO:0048011 nerve growth factor receptor signaling pathway
1.31 3.60e-03 GO:0048523 negative regulation of cellular process
1.90 4.23e-03 GO:0031401 positive regulation of protein modification process
2.93 4.33e-03 GO:0050852 T cell receptor signaling pathway
2.78 4.64e-03 GO:0071826 ribonucleoprotein complex subunit organization
1.58 4.74e-03 GO:0022403 cell cycle phase
1.55 4.75e-03 GO:0016192 vesicle-mediated transport
2.01 5.76e-03 GO:0032269 negative regulation of cellular protein metabolic process
1.22 6.01e-03 GO:0031323 regulation of cellular metabolic process
1.51 6.02e-03 GO:0045184 establishment of protein localization
3.04 6.34e-03 GO:0071214 cellular response to abiotic stimulus
2.52 6.44e-03 GO:0051320 S phase
3.13 6.52e-03 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
3.13 6.52e-03 GO:0072395 signal transduction involved in cell cycle checkpoint
3.13 6.52e-03 GO:0072401 signal transduction involved in DNA integrity checkpoint
3.13 6.52e-03 GO:0072404 signal transduction involved in G1/S transition checkpoint
3.13 6.52e-03 GO:0072413 signal transduction involved in mitotic cell cycle checkpoint
3.13 6.52e-03 GO:0072422 signal transduction involved in DNA damage checkpoint
3.13 6.52e-03 GO:0072431 signal transduction involved in mitotic cell cycle G1/S transition DNA damage checkpoint
3.13 6.52e-03 GO:0072474 signal transduction involved in mitotic cell cycle G1/S checkpoint
2.79 6.54e-03 GO:2000045 regulation of G1/S transition of mitotic cell cycle
1.51 6.69e-03 GO:0015031 protein transport
1.78 8.32e-03 GO:0032270 positive regulation of cellular protein metabolic process
3.08 8.69e-03 GO:0031294 lymphocyte costimulation
3.08 8.69e-03 GO:0031295 T cell costimulation
1.97 8.82e-03 GO:0051248 negative regulation of protein metabolic process
2.82 9.20e-03 GO:0031575 mitotic cell cycle G1/S transition checkpoint
2.82 9.20e-03 GO:0071779 G1/S transition checkpoint
1.64 9.40e-03 GO:0006928 cellular component movement
1.51 1.06e-02 GO:0044093 positive regulation of molecular function
1.92 1.06e-02 GO:0007346 regulation of mitotic cell cycle
1.75 1.09e-02 GO:0051247 positive regulation of protein metabolic process
2.95 1.09e-02 GO:0031571 mitotic cell cycle G1/S transition DNA damage checkpoint
1.70 1.29e-02 GO:0016044 cellular membrane organization
2.48 1.37e-02 GO:0000084 S phase of mitotic cell cycle
2.98 1.51e-02 GO:0071158 positive regulation of cell cycle arrest
1.69 1.55e-02 GO:0061024 membrane organization
1.79 1.59e-02 GO:0012502 induction of programmed cell death
2.27 1.62e-02 GO:0000082 G1/S transition of mitotic cell cycle
2.45 1.66e-02 GO:0008624 induction of apoptosis by extracellular signals
2.59 1.78e-02 GO:0002758 innate immune response-activating signal transduction
1.41 1.80e-02 GO:0044248 cellular catabolic process
1.43 2.08e-02 GO:0008104 protein localization
2.76 2.09e-02 GO:0008063 Toll signaling pathway
2.76 2.09e-02 GO:0034142 toll-like receptor 4 signaling pathway
1.57 2.19e-02 GO:0051276 chromosome organization
1.40 2.36e-02 GO:0010604 positive regulation of macromolecule metabolic process
2.46 2.37e-02 GO:0090068 positive regulation of cell cycle process
1.51 2.64e-02 GO:0071844 cellular component assembly at cellular level
2.54 2.69e-02 GO:0002218 activation of innate immune response
2.04 2.70e-02 GO:0022613 ribonucleoprotein complex biogenesis
1.64 2.71e-02 GO:0070271 protein complex biogenesis
2.16 2.80e-02 GO:0031400 negative regulation of protein modification process
1.76 2.92e-02 GO:0006917 induction of apoptosis
1.65 3.55e-02 GO:0006325 chromatin organization
1.63 3.90e-02 GO:0006461 protein complex assembly
2.39 4.16e-02 GO:0016197 endosome transport
1.99 4.22e-02 GO:0071843 cellular component biogenesis at cellular level
1.73 4.22e-02 GO:0016568 chromatin modification
1.37 4.25e-02 GO:0009893 positive regulation of metabolic process
2.12 4.37e-02 GO:0006417 regulation of translation
2.58 4.48e-02 GO:0002224 toll-like receptor signaling pathway
2.88 4.58e-02 GO:0031124 mRNA 3'-end processing
2.88 4.58e-02 GO:0034138 toll-like receptor 3 signaling pathway
1.62 4.78e-02 GO:0001775 cell activation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.22 3.63e-39 GO:0044424 intracellular part
1.21 2.42e-36 GO:0005622 intracellular
1.30 1.28e-31 GO:0005737 cytoplasm
1.22 1.66e-24 GO:0043229 intracellular organelle
1.22 2.33e-24 GO:0043226 organelle
1.24 2.27e-23 GO:0043227 membrane-bounded organelle
1.24 2.35e-23 GO:0043231 intracellular membrane-bounded organelle
1.71 6.42e-23 GO:0005829 cytosol
1.50 8.76e-23 GO:0032991 macromolecular complex
1.31 7.90e-19 GO:0044444 cytoplasmic part
1.32 1.32e-17 GO:0044446 intracellular organelle part
1.31 6.04e-17 GO:0005634 nucleus
1.31 1.79e-16 GO:0044422 organelle part
1.46 6.57e-15 GO:0043234 protein complex
1.55 1.97e-14 GO:0044428 nuclear part
1.51 1.65e-13 GO:0031974 membrane-enclosed lumen
1.58 2.16e-13 GO:0031981 nuclear lumen
1.51 3.48e-13 GO:0070013 intracellular organelle lumen
1.70 4.69e-13 GO:0005654 nucleoplasm
1.50 7.06e-13 GO:0043233 organelle lumen
1.07 7.17e-12 GO:0044464 cell part
1.07 7.58e-12 GO:0005623 cell
1.99 3.24e-09 GO:0030529 ribonucleoprotein complex
1.76 8.69e-08 GO:0044451 nucleoplasm part
1.31 6.44e-06 GO:0043228 non-membrane-bounded organelle
1.31 6.44e-06 GO:0043232 intracellular non-membrane-bounded organelle
3.60 8.15e-05 GO:0034708 methyltransferase complex
3.60 8.15e-05 GO:0035097 histone methyltransferase complex
1.75 2.47e-04 GO:0005768 endosome
5.30 1.62e-03 GO:0030530 heterogeneous nuclear ribonucleoprotein complex
2.01 1.68e-03 GO:0016604 nuclear body
1.90 2.06e-03 GO:0000323 lytic vacuole
1.90 2.06e-03 GO:0005764 lysosome
1.45 2.23e-03 GO:0005794 Golgi apparatus
8.18 4.36e-03 GO:0005885 Arp2/3 protein complex
1.28 5.88e-03 GO:0031090 organelle membrane
2.88 7.73e-03 GO:0000502 proteasome complex
1.57 8.72e-03 GO:0005694 chromosome
4.52 2.71e-02 GO:0031201 SNARE complex
1.74 2.86e-02 GO:0015629 actin cytoskeleton
1.71 2.95e-02 GO:0005773 vacuole
2.07 3.43e-02 GO:0005769 early endosome

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.42 1.35e-49 GO:0005515 protein binding
1.17 7.38e-28 GO:0005488 binding
1.83 1.01e-10 GO:0003723 RNA binding
1.32 1.06e-04 GO:0000166 nucleotide binding
1.22 5.42e-03 GO:0003676 nucleic acid binding
3.49 6.73e-03 GO:0043021 ribonucleoprotein binding
3.34 2.39e-02 GO:0003823 antigen binding