Motif ID: NKX6-1,2.p2

Z-value: 0.875


Transcription factors associated with NKX6-1,2.p2:

Gene SymbolEntrez IDGene Name
NKX6-1 4825 NK6 homeobox 1
NKX6-2 84504 NK6 homeobox 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NKX6-1chr4_-_85419386-0.128.1e-02Click!


Activity profile for motif NKX6-1,2.p2.

activity profile for motif NKX6-1,2.p2


Sorted Z-values histogram for motif NKX6-1,2.p2

Sorted Z-values for motif NKX6-1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX6-1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_+_169418167 15.770 NM_001166108
NM_016081
PALLD

palladin, cytoskeletal associated protein

chr3_-_79817058 12.583 NM_002941
ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr8_+_132991171 12.167 EFR3A
EFR3 homolog A (S. cerevisiae)
chr7_+_94297448 8.988 PEG10
paternally expressed 10
chr7_+_23286420 8.578 GPNMB
glycoprotein (transmembrane) nmb
chr2_-_238322840 8.458 NM_004369
NM_057164
NM_057165
NM_057166
NM_057167
COL6A3




collagen, type VI, alpha 3




chr7_+_23286384 8.440 GPNMB
glycoprotein (transmembrane) nmb
chr1_+_84647342 7.991 NM_001242862
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr6_+_87969619 7.716 ZNF292
zinc finger protein 292
chr7_-_137686814 7.434 NM_001253775
NM_194071
CREB3L2

cAMP responsive element binding protein 3-like 2

chr7_+_23286386 7.388 GPNMB
glycoprotein (transmembrane) nmb
chr2_-_238322815 7.316 COL6A3
collagen, type VI, alpha 3
chr5_+_140729723 6.915 NM_018922
NM_032095
PCDHGB1

protocadherin gamma subfamily B, 1

chr7_+_23286390 6.705 GPNMB
glycoprotein (transmembrane) nmb
chrX_+_80457302 6.285 NM_003022
SH3BGRL
SH3 domain binding glutamic acid-rich protein like
chr12_-_91505541 6.133 NM_002345
LUM
lumican
chr20_+_11898536 6.084 NM_014962
BTBD3
BTB (POZ) domain containing 3
chrX_+_102840412 5.848 NM_001006935
NM_001006937
NM_024863
TCEAL4


transcription elongation factor A (SII)-like 4


chr1_-_226926875 5.838 NM_002221
ITPKB
inositol-trisphosphate 3-kinase B
chr12_-_91505215 5.766 LUM
lumican
chr7_-_137028533 5.737 NM_002825
PTN
pleiotrophin
chr4_+_70894129 5.635 NM_000200
HTN3
histatin 3
chr20_+_19915716 5.607 RIN2
Ras and Rab interactor 2
chr1_+_104159953 5.550 NM_000699
AMY2A
amylase, alpha 2A (pancreatic)
chr4_+_88896801 5.548 NM_000582
NM_001040058
NM_001040060
NM_001251829
NM_001251830
SPP1




secreted phosphoprotein 1




chr7_+_23286277 5.531 NM_001005340
NM_002510
GPNMB

glycoprotein (transmembrane) nmb

chr1_-_93342706 5.498 NM_001252271
FAM69A
family with sequence similarity 69, member A
chrX_-_10535476 5.494 NM_001193278
NM_001193279
NM_001193280
NM_001193281
MID1



midline 1 (Opitz/BBB syndrome)



chrX_+_47441650 5.148 NM_003254
TIMP1
TIMP metallopeptidase inhibitor 1
chr2_-_151344145 4.945 NM_005168
RND3
Rho family GTPase 3
chr4_-_186732047 4.821 NM_001145672
SORBS2
sorbin and SH3 domain containing 2
chr5_+_140739589 4.796 NM_018923
NM_032096
PCDHGB2

protocadherin gamma subfamily B, 2

chr4_-_186733372 4.769 NM_003603
NM_001145670
SORBS2

sorbin and SH3 domain containing 2

chr6_+_114178516 4.625 NM_002356
MARCKS
myristoylated alanine-rich protein kinase C substrate
chr6_-_75970566 4.619 TMEM30A
transmembrane protein 30A
chr4_-_83347222 4.603 HNRPDL
heterogeneous nuclear ribonucleoprotein D-like
chr18_-_51690988 4.597 MBD2
methyl-CpG binding domain protein 2
chr2_-_175712276 4.497 NM_001206602
CHN1
chimerin (chimaerin) 1
chr4_+_166299942 4.462 NM_001873
CPE
carboxypeptidase E
chr4_+_88896899 4.454 SPP1
secreted phosphoprotein 1
chrX_+_47441802 4.288 TIMP1
TIMP metallopeptidase inhibitor 1
chrX_-_100872926 4.178 NM_001009584
NM_001184768
NM_019007
ARMCX6


armadillo repeat containing, X-linked 6


chr15_+_25068793 4.171 NM_022806
NM_022807
NM_022808
SNRPN


small nuclear ribonucleoprotein polypeptide N


chr11_+_17332454 4.101


chr2_+_108994366 4.092 NM_006588
SULT1C4
sulfotransferase family, cytosolic, 1C, member 4
chr4_+_55095263 4.023 NM_006206
PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr10_+_63808968 3.965 NM_001244638
ARID5B
AT rich interactive domain 5B (MRF1-like)
chr1_-_21377452 3.920 EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr7_-_26232148 3.913 HNRNPA2B1
heterogeneous nuclear ribonucleoprotein A2/B1
chr3_-_114790221 3.781 NM_001164343
ZBTB20
zinc finger and BTB domain containing 20
chr1_-_115269672 3.697 CSDE1
cold shock domain containing E1, RNA-binding
chr1_+_104097321 3.694 NM_020978
AMY2B
amylase, alpha 2B (pancreatic)
chr4_+_41700736 3.614 LIMCH1
LIM and calponin homology domains 1
chr22_-_26961333 3.587 NM_001008566
TPST2
tyrosylprotein sulfotransferase 2
chr8_+_26150731 3.543 NM_001177591
PPP2R2A
protein phosphatase 2, regulatory subunit B, alpha
chr4_+_83956238 3.453 NM_016129
COPS4
COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis)
chr4_+_71337674 3.428 NM_001145007
MUC7
mucin 7, secreted
chr4_+_41258895 3.416 NM_004181
UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr1_+_53480616 3.367 SCP2
sterol carrier protein 2
chr2_-_47134945 3.359 MCFD2
multiple coagulation factor deficiency 2
chr12_+_119616594 3.322 NM_014365
HSPB8
heat shock 22kDa protein 8
chr3_-_15382874 3.307 NM_001018009
SH3BP5
SH3-domain binding protein 5 (BTK-associated)
chr3_-_105421044 3.275 CBLB
Cas-Br-M (murine) ecotropic retroviral transforming sequence b
chr3_-_149421059 3.247 NM_001168278
WWTR1
WW domain containing transcription regulator 1
chrX_-_114252132 3.245 NM_000640
IL13RA2
interleukin 13 receptor, alpha 2
chr6_+_158733691 3.227 NM_001007466
NM_020245
TULP4

tubby like protein 4

chr12_-_6233684 3.195 NM_000552
VWF
von Willebrand factor
chr13_-_38172862 3.154 NM_001135934
NM_001135935
NM_001135936
NM_006475
POSTN



periostin, osteoblast specific factor



chr12_-_46633551 3.152 SLC38A1
solute carrier family 38, member 1
chr1_-_207095198 3.117 NM_001193338
NM_001142473
NM_005449
FAIM3


Fas apoptotic inhibitory molecule 3


chr12_-_54653317 3.096 NM_001127322
CBX5
chromobox homolog 5
chrX_-_10544852 3.083 NM_001193277
MID1
midline 1 (Opitz/BBB syndrome)
chr10_-_98321823 3.063 TM9SF3
transmembrane 9 superfamily member 3
chr6_+_26440699 3.060 NM_001242803
NM_006994
NM_197974
BTN3A3


butyrophilin, subfamily 3, member A3


chrX_+_80457597 3.051 SH3BGRL
SH3 domain binding glutamic acid-rich protein like
chr4_+_71337833 3.048 NM_152291
MUC7
mucin 7, secreted
chrX_-_23855456 2.993 RPL9
ribosomal protein L9
chr1_+_53480573 2.942 NM_001007099
NM_001007100
NM_001007250
SCP2


sterol carrier protein 2


chr5_+_67586466 2.914 NM_181504
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr12_-_54653369 2.910 NM_001127321
CBX5
chromobox homolog 5
chr1_-_21377387 2.874 EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr1_+_84630374 2.846 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr7_-_22862397 2.826 NM_019059
TOMM7
translocase of outer mitochondrial membrane 7 homolog (yeast)
chr9_+_706744 2.772 NM_153186
KANK1
KN motif and ankyrin repeat domains 1
chr5_-_150727088 2.741 NM_181776
SLC36A2
solute carrier family 36 (proton/amino acid symporter), member 2
chr12_+_9980076 2.730 NM_016523
KLRF1
killer cell lectin-like receptor subfamily F, member 1
chr5_-_111091947 2.696 NM_001142483
C5orf13
chromosome 5 open reading frame 13
chr4_+_41258909 2.690 UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chrX_+_70765479 2.640 OGT
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
chr6_+_26365397 2.562 NM_001197247
NM_001197249
NM_007047
NM_001197248
BTN3A2



butyrophilin, subfamily 3, member A2



chr3_+_23851933 2.560 NM_001202476
UBE2E1
ubiquitin-conjugating enzyme E2E 1
chr18_-_47018777 2.543 RPL17
ribosomal protein L17
chr2_-_10942642 2.524 PDIA6
protein disulfide isomerase family A, member 6
chr4_-_71532206 2.478 IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr2_+_183608329 2.448 DNAJC10
DnaJ (Hsp40) homolog, subfamily C, member 10
chr20_-_20036685 2.442 NM_016652
CRNKL1
crooked neck pre-mRNA splicing factor-like 1 (Drosophila)
chr12_+_28410132 2.438 NM_018318
CCDC91
coiled-coil domain containing 91
chr4_-_16900028 2.425 LDB2
LIM domain binding 2
chr4_+_88896838 2.423 SPP1
secreted phosphoprotein 1
chr12_+_62954275 2.416 MON2
MON2 homolog (S. cerevisiae)
chr4_+_88896868 2.415 SPP1
secreted phosphoprotein 1
chr5_+_140749830 2.398 NM_018924
NM_032097
PCDHGB3

protocadherin gamma subfamily B, 3

chr13_-_33760215 2.388 NM_001243466
NM_178007
STARD13

StAR-related lipid transfer (START) domain containing 13

chr17_+_68100994 2.386 NM_170742
KCNJ16
potassium inwardly-rectifying channel, subfamily J, member 16
chr2_+_109204904 2.385 NM_001193488
LIMS1
LIM and senescent cell antigen-like domains 1
chr2_+_109384601 2.384 RANBP2
RAN binding protein 2
chr9_+_82186846 2.375 NM_007005
TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr1_+_104198301 2.346 NM_004038
NM_001008218
NM_001008219
AMY1A
AMY1B
AMY1C
amylase, alpha 1A (salivary)
amylase, alpha 1B (salivary)
amylase, alpha 1C (salivary)
chr14_-_95599794 2.305 NM_001195573
DICER1
dicer 1, ribonuclease type III
chr3_+_63884074 2.288 NM_001177387
ATXN7
ataxin 7
chr4_+_71248794 2.278 NM_006685
SMR3B
submaxillary gland androgen regulated protein 3B
chr18_-_47018842 2.243 NM_001199356
NM_000985
NM_001035006
NM_001199340
NM_001199345
RPL17-C18ORF32
RPL17



RPL17-C18orf32 readthrough
ribosomal protein L17



chrX_-_78623006 2.236 NM_001171581
NM_004867
ITM2A

integral membrane protein 2A

chrX_-_10851808 2.208 NM_033290
MID1
midline 1 (Opitz/BBB syndrome)
chrX_-_33229428 2.167 NM_004006
DMD
dystrophin
chr1_-_6420719 2.166 NM_181865
ACOT7
acyl-CoA thioesterase 7
chr4_-_186877413 2.152 SORBS2
sorbin and SH3 domain containing 2
chr8_+_79428335 2.127 NM_006823
NM_181839
PKIA

protein kinase (cAMP-dependent, catalytic) inhibitor alpha

chr7_-_137028275 2.126 PTN
pleiotrophin
chr2_+_223725675 2.118 NM_004457
NM_203372
ACSL3

acyl-CoA synthetase long-chain family member 3

chr1_+_104292439 2.109 NM_004038
NM_001008218
NM_001008219
AMY1A
AMY1B
AMY1C
amylase, alpha 1A (salivary)
amylase, alpha 1B (salivary)
amylase, alpha 1C (salivary)
chrX_+_135230736 2.105 NM_001159700
FHL1
four and a half LIM domains 1
chr10_+_28878666 2.102 WAC
WW domain containing adaptor with coiled-coil
chr2_-_217560247 2.053 NM_000599
IGFBP5
insulin-like growth factor binding protein 5
chr9_+_116263706 2.049 NM_130795
RGS3
regulator of G-protein signaling 3
chr22_-_39268214 1.984 CBX6
chromobox homolog 6
chr9_+_34652125 1.966 NM_001142784
IL11RA
interleukin 11 receptor, alpha
chr22_-_39268169 1.963 CBX6
chromobox homolog 6
chr18_-_47018822 1.962 NM_001199341
NM_001199342
NM_001199343
NM_001199344
RPL17



ribosomal protein L17



chr3_-_149095413 1.961 TM4SF1
transmembrane 4 L six family member 1
chr1_-_110933635 1.933 SLC16A4
solute carrier family 16, member 4 (monocarboxylic acid transporter 5)
chr1_+_100316530 1.919 NM_000646
AGL
amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
chr17_-_17480325 1.906 PEMT
phosphatidylethanolamine N-methyltransferase
chr4_-_16900256 1.897 LDB2
LIM domain binding 2
chr4_-_16900348 1.875 NM_001130834
NM_001290
LDB2

LIM domain binding 2

chr15_+_44092618 1.870 NM_001199885
NM_016400
C15orf63

chromosome 15 open reading frame 63

chr2_+_172821874 1.861 HAT1
histone acetyltransferase 1
chr11_+_7618416 1.830 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr6_+_148663728 1.829 NM_015278
SASH1
SAM and SH3 domain containing 1
chr5_+_140868721 1.828 NM_018929
NM_032407
PCDHGC5

protocadherin gamma subfamily C, 5

chr1_+_79115476 1.786 NM_006417
IFI44
interferon-induced protein 44
chr7_-_41742666 1.778 NM_002192
INHBA
inhibin, beta A
chr19_+_41281281 1.777 NM_006533
MIA
melanoma inhibitory activity
chr1_+_84630575 1.767 NM_001242860
NM_001242861
PRKACB

protein kinase, cAMP-dependent, catalytic, beta

chr2_-_37544165 1.738 NM_005813
PRKD3
protein kinase D3
chr22_-_39268230 1.734 NM_014292
CBX6
chromobox homolog 6
chr1_-_197552304 1.720 DENND1B
DENN/MADD domain containing 1B
chr5_+_95066628 1.714 NM_014899
RHOBTB3
Rho-related BTB domain containing 3
chr2_-_74382352 1.680


chr13_-_45048436 1.668 NM_001243798
TSC22D1
TSC22 domain family, member 1
chr13_+_52598678 1.642 NM_021645
ALG11
UTP14C
asparagine-linked glycosylation 11, alpha-1,2-mannosyltransferase homolog (yeast)
UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast)
chr12_+_7023490 1.635 NM_001975
ENO2
enolase 2 (gamma, neuronal)
chr4_+_169013687 1.591 NM_007193
ANXA10
annexin A10
chr6_+_43738394 1.555 VEGFA
vascular endothelial growth factor A
chr5_+_140810181 1.533 PCDHGA12
protocadherin gamma subfamily A, 12
chr12_+_10457044 1.525 NM_001114396
KLRD1
killer cell lectin-like receptor subfamily D, member 1
chr6_-_87804773 1.524 NM_000735
NM_001252383
CGA

glycoprotein hormones, alpha polypeptide

chr4_-_110723334 1.519 NM_000204
CFI
complement factor I
chr5_+_42548144 1.514 NM_001242402
GHR
growth hormone receptor
chr1_+_84609941 1.493 NM_182948
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr5_+_49961732 1.449 NM_001178055
PARP8
poly (ADP-ribose) polymerase family, member 8
chr17_-_7307413 1.445 NM_152766
C17orf61-PLSCR3
C17orf61
C17orf61-PLSCR3 readthrough
chromosome 17 open reading frame 61
chr2_-_169103886 1.445 NM_013233
STK39
serine threonine kinase 39
chr13_-_110802708 1.444 COL4A1
collagen, type IV, alpha 1
chr11_-_115088628 1.435 CADM1
cell adhesion molecule 1
chr13_+_53602829 1.426 NM_006418
OLFM4
olfactomedin 4
chr2_+_228356287 1.419 AGFG1
ArfGAP with FG repeats 1
chr12_-_53600999 1.415 NM_000889
ITGB7
integrin, beta 7
chr22_+_31366662 1.394


chr22_-_43411129 1.392 PACSIN2
protein kinase C and casein kinase substrate in neurons 2
chr3_+_132036210 1.389 NM_001099
NM_001134194
ACPP

acid phosphatase, prostate

chr8_+_17822093 1.388 PCM1
pericentriolar material 1
chr5_+_42565562 1.385 NM_001242406
GHR
growth hormone receptor
chr6_+_26402464 1.370 NM_001145008
NM_001145009
NM_007048
NM_194441
BTN3A1



butyrophilin, subfamily 3, member A1



chr1_+_79086087 1.365 NM_006820
IFI44L
interferon-induced protein 44-like
chr22_-_38881529 1.345 DDX17
DEAD (Asp-Glu-Ala-Asp) box polypeptide 17
chr10_+_111765725 1.340 NM_019903
ADD3
adducin 3 (gamma)
chr3_-_149095333 1.339 TM4SF1
transmembrane 4 L six family member 1
chr17_+_68071386 1.333 NM_018658
NM_170741
KCNJ16

potassium inwardly-rectifying channel, subfamily J, member 16

chr5_+_140810126 1.332 NM_003735
NM_032094
PCDHGA12

protocadherin gamma subfamily A, 12

chr3_-_119582422 1.330 GSK3B
glycogen synthase kinase 3 beta
chr11_-_67205151 1.321 NM_005608
PTPRCAP
protein tyrosine phosphatase, receptor type, C-associated protein
chrX_+_123480131 1.316 NM_001114937
NM_002351
SH2D1A

SH2 domain containing 1A

chr7_-_137028370 1.305 PTN
pleiotrophin
chr4_+_41258941 1.301 UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr12_-_53601051 1.287 ITGB7
integrin, beta 7
chr17_+_8191814 1.282 NM_001177801
NM_001177802
NM_016492
RANGRF


RAN guanine nucleotide release factor


chr5_+_65372744 1.274 ERBB2IP
erbb2 interacting protein
chr9_+_97488943 1.264 NM_001193331
NM_032823
C9orf3

chromosome 9 open reading frame 3

chr18_+_72166822 1.262 NM_001168499
CNDP2
CNDP dipeptidase 2 (metallopeptidase M20 family)
chr3_-_58563070 1.261 FAM107A
family with sequence similarity 107, member A
chr4_-_186877869 1.249 NM_021069
SORBS2
sorbin and SH3 domain containing 2
chr2_+_109204745 1.242 NM_004987
LIMS1
LIM and senescent cell antigen-like domains 1
chr10_-_98325100 1.238 TM9SF3
transmembrane 9 superfamily member 3
chr10_+_86131546 1.227 FAM190B
family with sequence similarity 190, member B
chr1_+_146649544 1.222


chr15_-_66648991 1.220 NM_017858
TIPIN
TIMELESS interacting protein
chr12_+_118573945 1.206 PEBP1
phosphatidylethanolamine binding protein 1
chr9_+_97488993 1.205 C9orf3
chromosome 9 open reading frame 3
chr5_+_179132676 1.194 CANX
calnexin

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.40 4.84e-03 GO:0023052 signaling
1.42 7.33e-03 GO:0007165 signal transduction
1.59 1.13e-02 GO:0048513 organ development
1.49 1.54e-02 GO:0044267 cellular protein metabolic process
1.43 1.93e-02 GO:0019538 protein metabolic process
1.33 4.19e-02 GO:0051716 cellular response to stimulus

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.24 8.08e-06 GO:0005737 cytoplasm
4.31 2.56e-03 GO:0042470 melanosome
4.31 2.56e-03 GO:0048770 pigment granule

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.30 1.19e-06 GO:0005515 protein binding
29.47 1.58e-02 GO:0004556 alpha-amylase activity
29.47 1.58e-02 GO:0016160 amylase activity
9.83 4.08e-02 GO:0005161 platelet-derived growth factor receptor binding