Motif ID: NR4A2.p2

Z-value: 1.486


Transcription factors associated with NR4A2.p2:

monomer

Gene SymbolEntrez IDGene Name
NR4A2 4929 nuclear receptor subfamily 4, group A, member 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NR4A2chr2_-_157189040-0.101.4e-01Click!


Activity profile for motif NR4A2.p2.

activity profile for motif NR4A2.p2


Sorted Z-values histogram for motif NR4A2.p2

Sorted Z-values for motif NR4A2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NR4A2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr20_-_62130390 24.008 NM_001958
EEF1A2
eukaryotic translation elongation factor 1 alpha 2
chr12_-_16759531 22.737 NM_018640
LMO3
LIM domain only 3 (rhombotin-like 2)
chr12_-_16759430 20.469 LMO3
LIM domain only 3 (rhombotin-like 2)
chr12_-_16759939 19.086 NM_001243613
LMO3
LIM domain only 3 (rhombotin-like 2)
chr1_+_236849753 18.130 NM_001103
ACTN2
actinin, alpha 2
chr12_-_16759733 14.696 NM_001243610
LMO3
LIM domain only 3 (rhombotin-like 2)
chr5_+_80529138 14.666 NM_001099735
NM_001099736
NM_001825
CKMT2


creatine kinase, mitochondrial 2 (sarcomeric)


chr12_-_16760935 13.682 NM_001001395
NM_001243609
LMO3

LIM domain only 3 (rhombotin-like 2)

chr12_-_16758839 13.641 NM_001243612
LMO3
LIM domain only 3 (rhombotin-like 2)
chr8_+_145149985 13.211 CYC1
cytochrome c-1
chr1_-_229569839 13.125 NM_001100
ACTA1
actin, alpha 1, skeletal muscle
chr11_-_64528186 12.903 NM_001164716
NM_005609
PYGM

phosphorylase, glycogen, muscle

chr22_-_36019363 12.569 NM_203377
MB
myoglobin
chr1_-_154164551 12.391 NM_152263
TPM3
tropomyosin 3
chr17_+_4854383 12.274 NM_001193503
NM_001976
NM_053013
ENO3


enolase 3 (beta, muscle)


chr3_-_47957475 11.905


chr15_+_43885251 10.971 NM_020990
CKMT1B
CKMT1A
creatine kinase, mitochondrial 1B
creatine kinase, mitochondrial 1A
chr1_+_55464605 9.970 NM_057176
BSND
Bartter syndrome, infantile, with sensorineural deafness (Barttin)
chr19_+_35629727 9.412 NM_021902
FXYD1
FXYD domain containing ion transport regulator 1
chrX_+_38420690 8.712 NM_004615
TSPAN7
tetraspanin 7
chr16_+_58534045 8.462 NM_001242833
NM_001242834
NM_001242835
NM_001242836
NDRG4



NDRG family member 4



chr14_-_103988829 8.237 CKB
creatine kinase, brain
chr17_+_79670396 8.141 NM_002949
MRPL12
mitochondrial ribosomal protein L12
chr2_-_176046120 8.098 NM_001002258
NM_001190329
NM_001689
ATP5G3


ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)


chr7_-_10979683 7.950 NDUFA4
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9kDa
chr1_+_160085519 7.925 NM_000702
ATP1A2
ATPase, Na+/K+ transporting, alpha 2 polypeptide
chr3_-_46718898 7.660 NM_182775
ALS2CL
ALS2 C-terminal like
chr3_-_50340979 7.635 NM_007312
NM_033159
NM_153282
NM_153283
NM_153285
HYAL1




hyaluronoglucosaminidase 1




chr17_+_79670495 7.512 MRPL12
mitochondrial ribosomal protein L12
chr1_+_171810611 7.492 NM_001136127
NM_015569
DNM3

dynamin 3

chr9_+_130965666 7.471 DNM1
dynamin 1
chr1_+_36023389 7.434 NM_001014839
NM_001014841
NM_014284
NCDN


neurochondrin


chr16_+_72097124 7.287 NM_020995
HPR
haptoglobin-related protein
chr10_+_88428167 6.949 NM_001171610
LDB3
LIM domain binding 3
chr2_+_234621637 6.926 NM_019078
UGT1A5
UDP glucuronosyltransferase 1 family, polypeptide A5
chr12_+_6421816 6.870 NM_001144857
PLEKHG6
pleckstrin homology domain containing, family G (with RhoGef domain) member 6
chr16_+_6069094 6.826 NM_001142333
NM_018723
RBFOX1

RNA binding protein, fox-1 homolog (C. elegans) 1

chr22_-_39240016 6.757 NM_014293
NPTXR
neuronal pentraxin receptor
chr2_-_211168315 6.727 NM_079422
MYL1
myosin, light chain 1, alkali; skeletal, fast
chr9_+_130965608 6.710 NM_001005336
NM_004408
DNM1

dynamin 1

chr11_+_116700620 6.707 NM_000040
APOC3
apolipoprotein C-III
chr17_-_26903926 6.689 NM_005165
ALDOC
aldolase C, fructose-bisphosphate
chr15_-_75230354 6.614 COX5A
cytochrome c oxidase subunit Va
chr20_+_17207680 6.559 PCSK2
proprotein convertase subtilisin/kexin type 2
chr9_+_130965668 6.475 DNM1
dynamin 1
chr3_-_194072004 6.474 NM_001080513
CPN2
carboxypeptidase N, polypeptide 2
chr1_+_64088886 6.282 NM_001172818
PGM1
phosphoglucomutase 1
chr17_-_42992852 6.275 NM_001131019
NM_001242376
NM_002055
GFAP


glial fibrillary acidic protein


chr11_+_65190272 6.245


chr14_+_100150596 6.166 NM_006668
CYP46A1
cytochrome P450, family 46, subfamily A, polypeptide 1
chr8_+_145149978 6.155 CYC1
cytochrome c-1
chr2_+_74273449 6.038 NM_144993
TET3
tet methylcytosine dioxygenase 3
chr8_+_145149936 5.945 NM_001916
CYC1
cytochrome c-1
chr12_-_120554558 5.938 RAB35
RAB35, member RAS oncogene family
chr3_-_48647052 5.937 UQCRC1
ubiquinol-cytochrome c reductase core protein I
chr3_-_48647085 5.919 NM_003365
UQCRC1
ubiquinol-cytochrome c reductase core protein I
chr22_-_44258210 5.895 NM_014351
SULT4A1
sulfotransferase family 4A, member 1
chr17_-_26903854 5.829 ALDOC
aldolase C, fructose-bisphosphate
chr7_+_149571029 5.823 ATP6V0E2
ATPase, H+ transporting V0 subunit e2
chr7_-_44180911 5.821 NM_021223
MYL7
myosin, light chain 7, regulatory
chr3_+_195384918 5.763 SDHAP1
SDHAP2
succinate dehydrogenase complex, subunit A, flavoprotein pseudogene 1
succinate dehydrogenase complex, subunit A, flavoprotein pseudogene 2
chr1_+_233749749 5.649 NM_002245
KCNK1
potassium channel, subfamily K, member 1
chr4_+_41614911 5.646 NM_001112719
NM_001112720
LIMCH1

LIM and calponin homology domains 1

chrX_-_21776158 5.533 NM_014332
SMPX
small muscle protein, X-linked
chr2_+_234637772 5.476 NM_019093
UGT1A3
UDP glucuronosyltransferase 1 family, polypeptide A3
chr19_+_35630391 5.290 NM_005031
FXYD1
FXYD domain containing ion transport regulator 1
chr12_-_45307710 5.269 NM_001145110
NELL2
NEL-like 2 (chicken)
chr9_+_17578952 5.265 NM_003026
SH3GL2
SH3-domain GRB2-like 2
chr5_-_134914968 5.201 NM_004887
CXCL14
chemokine (C-X-C motif) ligand 14
chr16_+_30386097 5.186 NM_013292
MYLPF
myosin light chain, phosphorylatable, fast skeletal muscle
chr1_-_161193190 5.131 APOA2
apolipoprotein A-II
chr2_+_170366211 5.128 NM_006063
KBTBD10
kelch repeat and BTB (POZ) domain containing 10
chr7_-_72936592 5.079 NM_032408
BAZ1B
bromodomain adjacent to zinc finger domain, 1B
chr17_-_8066254 5.075 NM_014232
VAMP2
vesicle-associated membrane protein 2 (synaptobrevin 2)
chr2_+_98262497 5.050 NM_001862
COX5B
cytochrome c oxidase subunit Vb
chr2_+_234627423 4.963 NM_007120
UGT1A4
UDP glucuronosyltransferase 1 family, polypeptide A4
chr1_-_116311161 4.902 CASQ2
calsequestrin 2 (cardiac muscle)
chr17_-_56618178 4.882 NM_001198713
SEPT4
septin 4
chr20_+_57875647 4.873 EDN3
endothelin 3
chr3_-_52488030 4.871 NM_003280
TNNC1
troponin C type 1 (slow)
chr17_-_29624249 4.864 NM_002544
OMG
oligodendrocyte myelin glycoprotein
chr16_+_72088507 4.855 NM_001126102
NM_005143
HP

haptoglobin

chr2_-_31637553 4.824 XDH
xanthine dehydrogenase
chr12_-_52886971 4.810 NM_005554
KRT6A
keratin 6A
chr15_-_75230386 4.806 NM_004255
COX5A
cytochrome c oxidase subunit Va
chr12_+_119616594 4.789 NM_014365
HSPB8
heat shock 22kDa protein 8
chr1_-_116311330 4.754 CASQ2
calsequestrin 2 (cardiac muscle)
chr6_+_31554475 4.731 NM_205837
LST1
leukocyte specific transcript 1
chr11_-_790103 4.611 NM_016564
CEND1
cell cycle exit and neuronal differentiation 1
chr9_+_139839697 4.609 NM_000606
C8G
complement component 8, gamma polypeptide
chr1_+_64059479 4.600 NM_001172819
PGM1
phosphoglucomutase 1
chr8_-_110661007 4.571 NM_001099747
NM_001099748
NM_001099749
NM_001099750
NM_017786
SYBU




syntabulin (syntaxin-interacting)




chr8_+_21911062 4.553 NM_001114137
EPB49
erythrocyte membrane protein band 4.9 (dematin)
chr14_-_103989112 4.514 CKB
creatine kinase, brain
chr1_-_182573393 4.486 NM_002928
RGS16
regulator of G-protein signaling 16
chr19_+_54606141 4.484 NM_004542
NDUFA3
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa
chr15_+_91769329 4.471 SV2B
synaptic vesicle glycoprotein 2B
chr17_-_56606710 4.462 NM_004574
SEPT4
septin 4
chr20_-_33999760 4.447 UQCC
ubiquinol-cytochrome c reductase complex chaperone
chr2_+_210288668 4.402 NM_001039538
MAP2
microtubule-associated protein 2
chr5_-_42811959 4.336 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr6_+_30594607 4.291 NM_024909
NM_001031722
NM_001190724
ATAT1


alpha tubulin acetyltransferase 1


chr9_-_138853146 4.231 NM_016172
UBAC1
UBA domain containing 1
chr2_-_110874142 4.181 NM_005434
MALL
mal, T-cell differentiation protein-like
chr7_-_143059144 4.164 NM_014690
FAM131B
family with sequence similarity 131, member B
chr10_+_123872440 4.135 TACC2
transforming, acidic coiled-coil containing protein 2
chr12_-_57039785 4.124 NM_001686
ATP5B
ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
chr14_-_103989195 4.118 NM_001823
CKB
creatine kinase, brain
chr12_-_52867521 4.104 NM_173086
KRT6C
keratin 6C
chr19_-_55668956 4.081 NM_000363
TNNI3
troponin I type 3 (cardiac)
chr1_+_47603083 4.081 NM_001010969
CYP4A22
cytochrome P450, family 4, subfamily A, polypeptide 22
chr17_-_18218203 4.071 NM_004618
TOP3A
topoisomerase (DNA) III alpha
chr11_-_6462129 4.067 NM_000613
HPX
hemopexin
chr16_-_68269948 4.058 NM_024939
ESRP2
epithelial splicing regulatory protein 2
chr19_-_58067724 4.056 NM_001039654
ZNF550
zinc finger protein 550
chr20_-_48532036 4.040 SPATA2
spermatogenesis associated 2
chr2_-_152955810 4.038 CACNB4
calcium channel, voltage-dependent, beta 4 subunit
chr3_+_129247481 4.029 NM_000539
RHO
rhodopsin
chr12_+_98987674 4.021 SLC25A3
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3
chr15_+_59908908 4.018 GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr1_+_54359859 3.993 NM_000792
NM_001039715
NM_001039716
NM_213593
DIO1



deiodinase, iodothyronine, type I



chr3_+_159557649 3.978 NM_001197109
SCHIP1
schwannomin interacting protein 1
chr2_-_110873638 3.943 MALL
mal, T-cell differentiation protein-like
chr17_-_2614926 3.926 NM_015229
KIAA0664
KIAA0664
chr11_-_66139064 3.906 NM_001532
SLC29A2
solute carrier family 29 (nucleoside transporters), member 2
chr3_+_52813936 3.900 NM_001166435
NM_001166436
ITIH1

inter-alpha-trypsin inhibitor heavy chain 1

chr10_+_105036783 3.895 NM_032727
INA
internexin neuronal intermediate filament protein, alpha
chr18_-_74729049 3.892 NM_001025081
NM_001025090
NM_001025092
NM_002385
MBP



myelin basic protein



chr6_-_46293628 3.877 NM_005822
RCAN2
regulator of calcineurin 2
chr19_+_6739697 3.850 NM_004240
TRIP10
thyroid hormone receptor interactor 10
chr16_+_8807426 3.839 ABAT
4-aminobutyrate aminotransferase
chr10_-_50970321 3.833 NM_001143996
NM_001143997
NM_018245
OGDHL


oxoglutarate dehydrogenase-like


chr22_+_32149936 3.830 NM_001242897
DEPDC5
DEP domain containing 5
chr16_+_69796237 3.825 NM_007014
NM_199423
WWP2

WW domain containing E3 ubiquitin protein ligase 2

chr19_-_51869632 3.821 NM_001985
ETFB
electron-transfer-flavoprotein, beta polypeptide
chr9_-_138853007 3.819 UBAC1
UBA domain containing 1
chr11_-_107582733 3.788 NM_003063
SLN
sarcolipin
chr5_+_161274196 3.788 NM_000806
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr1_-_230849863 3.783 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr16_+_28891234 3.782 ATP2A1
ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
chr1_+_233749917 3.777 KCNK1
potassium channel, subfamily K, member 1
chr1_+_46640748 3.743 NM_005727
TSPAN1
tetraspanin 1
chr3_+_133464883 3.735 NM_001063
TF
transferrin
chr20_-_48531986 3.730 SPATA2
spermatogenesis associated 2
chr10_-_123353771 3.719 NM_001144916
FGFR2
fibroblast growth factor receptor 2
chr3_+_132379130 3.710 NM_024818
UBA5
ubiquitin-like modifier activating enzyme 5
chr19_-_51472003 3.699 NM_001012964
NM_001012965
KLK6

kallikrein-related peptidase 6

chr22_-_29711650 3.695 NM_001007279
NM_006477
RASL10A

RAS-like, family 10, member A

chr1_-_157108169 3.693 NM_005240
NM_001145312
ETV3

ets variant 3

chr18_-_43678251 3.669 ATP5A1
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
chr19_-_15235748 3.665 ILVBL
ilvB (bacterial acetolactate synthase)-like
chr11_+_47270433 3.657 NM_001130102
NR1H3
nuclear receptor subfamily 1, group H, member 3
chr10_-_101841593 3.646 NM_001308
CPN1
carboxypeptidase N, polypeptide 1
chr11_+_67798077 3.640 NM_002496
NDUFS8
NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase)
chr2_-_152590983 3.636 NM_001164507
NM_001164508
NM_004543
NEB


nebulin


chr2_-_21225640 3.634 APOB
apolipoprotein B (including Ag(x) antigen)
chr12_-_81991959 3.627 NM_001220477
NM_001220478
PPFIA2

protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2

chr11_-_624901 3.620 NM_001171968
NM_021924
NM_031264
CDHR5


cadherin-related family member 5


chr12_-_122296619 3.616 NM_002150
HPD
4-hydroxyphenylpyruvate dioxygenase
chr2_-_110873353 3.600 MALL
mal, T-cell differentiation protein-like
chr22_-_29711474 3.595 RASL10A
RAS-like, family 10, member A
chr5_-_176831385 3.565 F12
coagulation factor XII (Hageman factor)
chr1_+_161172125 3.548 NDUFS2
NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)
chr15_+_78441737 3.540 IDH3A
isocitrate dehydrogenase 3 (NAD+) alpha
chr7_+_45614081 3.536 NM_021116
ADCY1
adenylate cyclase 1 (brain)
chr7_-_10979752 3.523 NM_002489
NDUFA4
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9kDa
chr18_-_43678195 3.502 ATP5A1
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
chr11_+_1860718 3.500 NM_001145829
TNNI2
troponin I type 2 (skeletal, fast)
chr18_-_43678230 3.484 ATP5A1
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
chr10_+_105037441 3.470 INA
internexin neuronal intermediate filament protein, alpha
chr12_-_57039736 3.467 ATP5B
ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
chr8_+_21916858 3.447 EPB49
erythrocyte membrane protein band 4.9 (dematin)
chr16_+_103827 3.423 NM_024571
SNRNP25
small nuclear ribonucleoprotein 25kDa (U11/U12)
chr12_-_56106061 3.420 NM_001144997
ITGA7
integrin, alpha 7
chr5_-_149792370 3.411 NM_001025158
NM_001025159
NM_004355
CD74


CD74 molecule, major histocompatibility complex, class II invariant chain


chr18_-_43678233 3.401 ATP5A1
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
chr3_-_52312257 3.379 WDR82
WD repeat domain 82
chr16_+_103859 3.379 SNRNP25
small nuclear ribonucleoprotein 25kDa (U11/U12)
chr14_+_93389491 3.379 CHGA
chromogranin A (parathyroid secretory protein 1)
chr11_-_63933204 3.343 MACROD1
MACRO domain containing 1
chr1_+_20964414 3.342


chr16_-_89768094 3.324 NM_152339
SPATA2L
spermatogenesis associated 2-like
chr4_-_40517913 3.323 NM_019027
RBM47
RNA binding motif protein 47
chr7_+_86273219 3.313 NM_000840
GRM3
glutamate receptor, metabotropic 3
chr10_-_75634219 3.303 NM_001204492
NM_001222
NM_172169
NM_172170
NM_172171
NM_172173
CAMK2G





calcium/calmodulin-dependent protein kinase II gamma





chr19_-_51568323 3.303 NM_015596
KLK13
kallikrein-related peptidase 13
chr1_+_44412582 3.299 IPO13
importin 13
chr19_-_36246411 3.274 HSPB6
heat shock protein, alpha-crystallin-related, B6
chr1_-_201346804 3.267 NM_000364
NM_001001430
NM_001001431
NM_001001432
TNNT2



troponin T type 2 (cardiac)



chr11_-_111782447 3.265 NM_001885
CRYAB
crystallin, alpha B
chr17_-_7166263 3.247 NM_001185023
NM_001307
CLDN7

claudin 7

chr3_+_39509069 3.246 NM_182935
MOBP
myelin-associated oligodendrocyte basic protein
chr11_+_17757494 3.239 NM_001112741
NM_004976
KCNC1

potassium voltage-gated channel, Shaw-related subfamily, member 1

chr11_+_117947726 3.225 NM_001083947
NM_001173551
NM_001173552
NM_019894
TMPRSS4



transmembrane protease, serine 4



chr19_-_15235967 3.215 ILVBL
ilvB (bacterial acetolactate synthase)-like
chr4_+_76439653 3.213 NM_144721
THAP6
THAP domain containing 6
chrX_+_135230736 3.205 NM_001159700
FHL1
four and a half LIM domains 1
chr4_+_159593233 3.204 NM_004453
ETFDH
electron-transferring-flavoprotein dehydrogenase
chr1_-_27701302 3.195 NM_003665
NM_173452
FCN3

ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen)

chr18_-_43678257 3.175 ATP5A1
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.66 1.83e-21 GO:0006091 generation of precursor metabolites and energy
1.16 4.50e-21 GO:0009987 cellular process
2.93 2.75e-19 GO:0015980 energy derivation by oxidation of organic compounds
3.94 4.31e-19 GO:0045333 cellular respiration
4.16 5.11e-16 GO:0022904 respiratory electron transport chain
1.20 5.19e-14 GO:0065007 biological regulation
1.84 8.26e-14 GO:0055114 oxidation-reduction process
1.47 2.18e-11 GO:0065008 regulation of biological quality
3.18 3.96e-11 GO:0022900 electron transport chain
1.32 1.96e-10 GO:0023052 signaling
1.49 4.57e-10 GO:0044281 small molecule metabolic process
1.36 9.86e-10 GO:0006810 transport
1.78 1.72e-09 GO:0007267 cell-cell signaling
1.35 1.95e-09 GO:0051234 establishment of localization
1.18 3.02e-09 GO:0050789 regulation of biological process
1.66 3.45e-09 GO:0007154 cell communication
1.79 5.59e-09 GO:0042180 cellular ketone metabolic process
1.23 1.28e-08 GO:0032501 multicellular organismal process
1.29 7.23e-08 GO:0051179 localization
1.74 1.72e-07 GO:0019752 carboxylic acid metabolic process
1.74 1.72e-07 GO:0043436 oxoacid metabolic process
1.73 2.33e-07 GO:0006082 organic acid metabolic process
1.30 3.63e-07 GO:0048856 anatomical structure development
4.26 5.51e-07 GO:0042773 ATP synthesis coupled electron transport
4.26 5.51e-07 GO:0042775 mitochondrial ATP synthesis coupled electron transport
1.36 7.04e-07 GO:0042221 response to chemical stimulus
1.26 7.09e-07 GO:0032502 developmental process
1.16 1.97e-06 GO:0050794 regulation of cellular process
1.82 4.70e-06 GO:0019226 transmission of nerve impulse
1.82 4.70e-06 GO:0035637 multicellular organismal signaling
3.82 8.63e-06 GO:0006119 oxidative phosphorylation
1.17 9.31e-06 GO:0050896 response to stimulus
2.19 9.94e-06 GO:0008202 steroid metabolic process
2.37 1.01e-05 GO:0003012 muscle system process
1.57 1.33e-05 GO:0006811 ion transport
1.29 1.38e-05 GO:0048731 system development
1.26 1.56e-05 GO:0007165 signal transduction
1.25 3.34e-05 GO:0007275 multicellular organismal development
1.82 3.96e-05 GO:0007268 synaptic transmission
2.37 4.10e-05 GO:0006936 muscle contraction
1.68 4.19e-05 GO:0048878 chemical homeostasis
1.22 6.66e-05 GO:0051716 cellular response to stimulus
1.71 8.88e-05 GO:0044282 small molecule catabolic process
1.94 9.73e-05 GO:0032787 monocarboxylic acid metabolic process
1.14 1.20e-04 GO:0008152 metabolic process
4.07 1.38e-04 GO:0006120 mitochondrial electron transport, NADH to ubiquinone
1.65 1.57e-04 GO:0009725 response to hormone stimulus
1.35 2.27e-04 GO:0007166 cell surface receptor linked signaling pathway
1.42 3.82e-04 GO:0051239 regulation of multicellular organismal process
1.66 3.95e-04 GO:0007186 G-protein coupled receptor protein signaling pathway
1.38 4.13e-04 GO:0009653 anatomical structure morphogenesis
1.41 5.20e-04 GO:0010033 response to organic substance
2.44 6.86e-04 GO:0030802 regulation of cyclic nucleotide biosynthetic process
2.44 6.86e-04 GO:0030808 regulation of nucleotide biosynthetic process
1.58 6.99e-04 GO:0009719 response to endogenous stimulus
2.49 8.60e-04 GO:0030817 regulation of cAMP biosynthetic process
2.47 1.09e-03 GO:0030814 regulation of cAMP metabolic process
1.71 1.12e-03 GO:0055082 cellular chemical homeostasis
1.51 1.31e-03 GO:0055085 transmembrane transport
2.38 1.35e-03 GO:0030799 regulation of cyclic nucleotide metabolic process
2.31 1.58e-03 GO:0006820 anion transport
1.66 1.77e-03 GO:0044283 small molecule biosynthetic process
1.67 2.26e-03 GO:0050801 ion homeostasis
1.48 2.65e-03 GO:0042592 homeostatic process
1.62 2.97e-03 GO:0019725 cellular homeostasis
1.69 3.62e-03 GO:0006873 cellular ion homeostasis
1.58 3.91e-03 GO:0009887 organ morphogenesis
3.22 5.54e-03 GO:0061041 regulation of wound healing
1.24 5.84e-03 GO:0048518 positive regulation of biological process
1.28 5.94e-03 GO:0048869 cellular developmental process
1.29 5.95e-03 GO:0030154 cell differentiation
1.34 7.68e-03 GO:0007399 nervous system development
2.80 8.58e-03 GO:0015711 organic anion transport
2.46 8.85e-03 GO:0045761 regulation of adenylate cyclase activity
2.41 1.40e-02 GO:0031279 regulation of cyclase activity
1.42 1.54e-02 GO:0006629 lipid metabolic process
1.59 1.65e-02 GO:0006753 nucleoside phosphate metabolic process
1.59 1.65e-02 GO:0009117 nucleotide metabolic process
1.13 1.67e-02 GO:0044237 cellular metabolic process
2.16 1.83e-02 GO:0006006 glucose metabolic process
2.91 1.94e-02 GO:0007194 negative regulation of adenylate cyclase activity
2.91 1.94e-02 GO:0031280 negative regulation of cyclase activity
2.91 1.94e-02 GO:0051350 negative regulation of lyase activity
1.76 1.97e-02 GO:0032870 cellular response to hormone stimulus
1.50 2.03e-02 GO:0046483 heterocycle metabolic process
2.36 2.18e-02 GO:0051339 regulation of lyase activity
1.24 2.56e-02 GO:0048522 positive regulation of cellular process
2.30 2.61e-02 GO:0003001 generation of a signal involved in cell-cell signaling
2.30 2.61e-02 GO:0023061 signal release
2.86 2.64e-02 GO:0034339 regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor
1.87 2.81e-02 GO:0032101 regulation of response to external stimulus
2.08 3.40e-02 GO:0019935 cyclic-nucleotide-mediated signaling
1.62 3.57e-02 GO:0043086 negative regulation of catalytic activity
1.99 3.75e-02 GO:0006732 coenzyme metabolic process
1.53 3.86e-02 GO:0006812 cation transport
2.26 3.92e-02 GO:0019933 cAMP-mediated signaling
1.95 4.10e-02 GO:0034220 ion transmembrane transport
3.91 4.59e-02 GO:0008207 C21-steroid hormone metabolic process
1.85 4.72e-02 GO:0051186 cofactor metabolic process
4.52 4.74e-02 GO:0015985 energy coupled proton transport, down electrochemical gradient
4.52 4.74e-02 GO:0015986 ATP synthesis coupled proton transport

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.65 9.56e-18 GO:0005743 mitochondrial inner membrane
2.46 2.40e-15 GO:0019866 organelle inner membrane
1.50 3.07e-15 GO:0044459 plasma membrane part
1.64 9.85e-14 GO:0005739 mitochondrion
1.23 1.03e-12 GO:0044444 cytoplasmic part
2.11 5.14e-12 GO:0031966 mitochondrial membrane
1.17 5.37e-12 GO:0005737 cytoplasm
1.87 8.52e-12 GO:0044429 mitochondrial part
2.05 1.97e-11 GO:0005740 mitochondrial envelope
3.12 1.44e-10 GO:0044455 mitochondrial membrane part
1.61 4.36e-10 GO:0000267 cell fraction
1.57 6.24e-10 GO:0005887 integral to plasma membrane
1.55 1.37e-09 GO:0031226 intrinsic to plasma membrane
1.68 3.54e-09 GO:0005626 insoluble fraction
3.70 1.26e-08 GO:0070469 respiratory chain
1.25 1.26e-08 GO:0071944 cell periphery
1.25 1.55e-08 GO:0005886 plasma membrane
1.66 2.62e-08 GO:0005624 membrane fraction
1.65 8.63e-08 GO:0005615 extracellular space
1.64 9.50e-07 GO:0031975 envelope
3.47 1.47e-06 GO:0005746 mitochondrial respiratory chain
1.62 3.57e-06 GO:0031967 organelle envelope
3.97 1.40e-05 GO:0005747 mitochondrial respiratory chain complex I
3.97 1.40e-05 GO:0030964 NADH dehydrogenase complex
3.97 1.40e-05 GO:0045271 respiratory chain complex I
1.46 4.25e-05 GO:0044421 extracellular region part
1.12 1.27e-04 GO:0016020 membrane
1.04 1.75e-04 GO:0044464 cell part
1.04 1.83e-04 GO:0005623 cell
1.72 2.70e-04 GO:0043005 neuron projection
1.46 4.57e-04 GO:0042995 cell projection
1.27 8.10e-04 GO:0031090 organelle membrane
1.07 8.30e-04 GO:0044424 intracellular part
1.95 1.60e-03 GO:0030141 stored secretory granule
2.25 1.66e-03 GO:0043292 contractile fiber
1.82 2.49e-03 GO:0005759 mitochondrial matrix
1.64 3.29e-03 GO:0045202 synapse
1.06 5.36e-03 GO:0005622 intracellular
1.78 8.68e-03 GO:0042598 vesicular fraction
2.18 9.26e-03 GO:0030016 myofibril
2.82 1.31e-02 GO:0031983 vesicle lumen
1.78 1.42e-02 GO:0005792 microsome
2.16 1.44e-02 GO:0044449 contractile fiber part
1.12 1.98e-02 GO:0044422 organelle part
4.31 3.06e-02 GO:0005753 mitochondrial proton-transporting ATP synthase complex
1.85 3.82e-02 GO:0030424 axon
6.11 3.90e-02 GO:0034366 spherical high-density lipoprotein particle
5.18 4.47e-02 GO:0001917 photoreceptor inner segment
1.64 4.58e-02 GO:0044456 synapse part
1.38 4.74e-02 GO:0031982 vesicle
1.12 4.96e-02 GO:0044446 intracellular organelle part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.16 2.19e-07 GO:0005515 protein binding
1.67 5.81e-07 GO:0016491 oxidoreductase activity
1.08 7.40e-07 GO:0005488 binding
1.64 1.00e-06 GO:0015075 ion transmembrane transporter activity
1.48 2.19e-06 GO:0005215 transporter activity
1.53 6.52e-06 GO:0022857 transmembrane transporter activity
4.18 8.57e-06 GO:0003954 NADH dehydrogenase activity
4.18 8.57e-06 GO:0008137 NADH dehydrogenase (ubiquinone) activity
4.18 8.57e-06 GO:0050136 NADH dehydrogenase (quinone) activity
1.50 8.68e-06 GO:0022892 substrate-specific transporter activity
2.24 2.10e-05 GO:0015077 monovalent inorganic cation transmembrane transporter activity
1.52 3.68e-05 GO:0022891 substrate-specific transmembrane transporter activity
1.47 7.69e-05 GO:0005102 receptor binding
2.98 1.16e-04 GO:0005200 structural constituent of cytoskeleton
3.60 1.86e-04 GO:0016655 oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor
3.35 1.87e-04 GO:0003707 steroid hormone receptor activity
1.99 1.87e-04 GO:0022890 inorganic cation transmembrane transporter activity
2.60 2.67e-04 GO:0015078 hydrogen ion transmembrane transporter activity
1.61 3.28e-04 GO:0008324 cation transmembrane transporter activity
3.17 5.88e-04 GO:0004879 ligand-dependent nuclear receptor activity
2.22 6.83e-04 GO:0008509 anion transmembrane transporter activity
2.61 2.17e-03 GO:0016651 oxidoreductase activity, acting on NADH or NADPH
1.64 2.53e-03 GO:0008289 lipid binding
2.91 5.11e-03 GO:0033293 monocarboxylic acid binding
1.14 5.15e-03 GO:0003824 catalytic activity
2.63 1.79e-02 GO:0005496 steroid binding
1.63 2.80e-02 GO:0022804 active transmembrane transporter activity
3.62 3.19e-02 GO:0051539 4 iron, 4 sulfur cluster binding
1.97 4.19e-02 GO:0031406 carboxylic acid binding
1.98 4.66e-02 GO:0004252 serine-type endopeptidase activity