Motif ID: NRF1.p2

Z-value: 6.613


Transcription factors associated with NRF1.p2:

Gene SymbolEntrez IDGene Name
NRF1 4899 nuclear respiratory factor 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NRF1chr7_+_129269916-0.491.0e-14Click!


Activity profile for motif NRF1.p2.

activity profile for motif NRF1.p2


Sorted Z-values histogram for motif NRF1.p2

Sorted Z-values for motif NRF1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NRF1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_+_110045516 148.800 NM_002874
RAD23B
RAD23 homolog B (S. cerevisiae)
chr9_+_110045551 141.032 RAD23B
RAD23 homolog B (S. cerevisiae)
chr12_+_131356557 131.599 NM_006325
RAN
RAN, member RAS oncogene family
chr2_+_264843 122.474 NM_001040649
NM_004300
NM_007099
ACP1


acid phosphatase 1, soluble


chr5_+_170814707 122.259 NM_001037738
NM_002520
NM_199185
NPM1


nucleophosmin (nucleolar phosphoprotein B23, numatrin)


chr12_+_131356617 118.029 RAN
RAN, member RAS oncogene family
chr9_+_110045565 116.429 RAD23B
RAD23 homolog B (S. cerevisiae)
chr19_-_50432952 112.614 NM_016553
NUP62
nucleoporin 62kDa
chr5_+_170814952 111.630 NPM1
nucleophosmin (nucleolar phosphoprotein B23, numatrin)
chr2_-_33824294 111.598 NM_015475
FAM98A
family with sequence similarity 98, member A
chr11_-_64545231 102.151 NM_001178031
SF1
splicing factor 1
chr8_-_117887045 101.282 NM_006265
RAD21
RAD21 homolog (S. pombe)
chr8_-_117886881 100.019 RAD21
RAD21 homolog (S. pombe)
chr19_-_50432734 96.429 NM_012346
NM_153718
NM_153719
NM_001193357
NM_172374
NUP62



IL4I1
nucleoporin 62kDa



interleukin 4 induced 1
chr17_+_49337909 94.581 UTP18
UTP18 small subunit (SSU) processome component homolog (yeast)
chr12_-_54070108 92.998 NM_005176
ATP5G2
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
chr17_+_49337892 92.058 NM_016001
UTP18
UTP18 small subunit (SSU) processome component homolog (yeast)
chr8_+_42249383 91.510 VDAC3
voltage-dependent anion channel 3
chr16_-_66864864 89.963 NM_001018159
NM_001018160
NM_003905
NAE1


NEDD8 activating enzyme E1 subunit 1


chr16_-_66864803 89.413 NAE1
NEDD8 activating enzyme E1 subunit 1
chr17_+_49337882 85.202 UTP18
UTP18 small subunit (SSU) processome component homolog (yeast)
chr1_-_156308099 83.169 NM_001008800
NM_005998
CCT3

chaperonin containing TCP1, subunit 3 (gamma)

chr8_+_42249278 82.983 NM_001135694
NM_005662
VDAC3

voltage-dependent anion channel 3

chr5_-_133561805 79.187 NM_002715
PPP2CA
protein phosphatase 2, catalytic subunit, alpha isozyme
chr19_-_55918980 78.940 UBE2S
ubiquitin-conjugating enzyme E2S
chr20_-_57617836 78.710 NM_016045
SLMO2
slowmo homolog 2 (Drosophila)
chr1_-_156308064 78.312 CCT3
chaperonin containing TCP1, subunit 3 (gamma)
chrX_-_16888462 76.339 NM_002893
RBBP7
retinoblastoma binding protein 7
chr1_-_156308047 75.760 CCT3
chaperonin containing TCP1, subunit 3 (gamma)
chr9_-_124922049 75.021 NM_014222
NDUFA8
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa
chrX_-_153707595 74.820 NM_006014
LAGE3
L antigen family, member 3
chr19_-_2427530 74.607 TIMM13
translocase of inner mitochondrial membrane 13 homolog (yeast)
chr12_-_54069856 73.721 ATP5G2
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
chr8_+_42249393 73.599 VDAC3
voltage-dependent anion channel 3
chr1_-_156307971 73.282 CCT3
chaperonin containing TCP1, subunit 3 (gamma)
chr14_-_23058062 73.213 DAD1
defender against cell death 1
chr4_-_120987890 72.571 NM_002358
MAD2L1
MAD2 mitotic arrest deficient-like 1 (yeast)
chr5_+_162887516 72.457 NM_001142556
NM_001142557
NM_012484
NM_012485
HMMR



hyaluronan-mediated motility receptor (RHAMM)



chr1_+_154947166 72.274 CKS1B
CDC28 protein kinase regulatory subunit 1B
chr19_-_2328566 72.062 NM_016199
LSM7
LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr2_+_216974006 71.318 NM_021141
XRCC5
X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
chr1_+_154947147 70.762 CKS1B
CDC28 protein kinase regulatory subunit 1B
chr19_+_47634133 70.295 SAE1
SUMO1 activating enzyme subunit 1
chr14_-_23058114 69.906 NM_001344
DAD1
defender against cell death 1
chr19_+_47634044 69.567 NM_001145713
NM_001145714
NM_005500
SAE1


SUMO1 activating enzyme subunit 1


chr3_+_150321065 69.519 NM_016275
SELT
selenoprotein T
chr10_-_16859408 69.468 NM_012425
NM_152724
RSU1

Ras suppressor protein 1

chr20_-_32699915 69.188 EIF2S2
eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
chr19_+_47634148 69.154 SAE1
SUMO1 activating enzyme subunit 1
chrX_-_16888175 66.288 RBBP7
retinoblastoma binding protein 7
chr19_-_2427874 66.148 NM_012458
TIMM13
translocase of inner mitochondrial membrane 13 homolog (yeast)
chr19_+_47634118 65.515 SAE1
SUMO1 activating enzyme subunit 1
chr1_+_154947116 65.483 NM_001826
CKS1B
CDC28 protein kinase regulatory subunit 1B
chr5_+_10250410 65.431 CCT5
chaperonin containing TCP1, subunit 5 (epsilon)
chr2_-_130939146 64.568 NM_001171083
NM_017751
NM_017951
SMPD4


sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3)


chr3_+_120315127 64.178 NM_001168331
NM_004547
NDUFB4

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa

chr14_+_67827087 63.785 EIF2S1
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
chr3_+_120315176 63.154 NDUFB4
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa
chrX_-_16888442 62.734 RBBP7
retinoblastoma binding protein 7
chr5_+_10250281 62.687 NM_012073
CCT5
chaperonin containing TCP1, subunit 5 (epsilon)
chr17_+_40761658 61.590 TUBG1
tubulin, gamma 1
chr12_+_131356640 61.401 RAN
RAN, member RAS oncogene family
chr5_+_10250440 60.829 CCT5
chaperonin containing TCP1, subunit 5 (epsilon)
chr4_-_1242742 59.960 CTBP1
C-terminal binding protein 1
chr5_-_133561745 59.305 PPP2CA
protein phosphatase 2, catalytic subunit, alpha isozyme
chr19_+_17416476 59.290 NM_023937
MRPL34
mitochondrial ribosomal protein L34
chr11_-_77850633 59.278 ALG8
asparagine-linked glycosylation 8, alpha-1,3-glucosyltransferase homolog (S. cerevisiae)
chr1_+_41445402 59.098 CTPS
CTP synthase
chr6_-_31774579 59.038 LSM2
LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr2_+_130939500 59.037 NM_025029
MZT2B
mitotic spindle organizing protein 2B
chr3_-_49066858 58.995 NM_000884
IMPDH2
IMP (inosine 5'-monophosphate) dehydrogenase 2
chr9_-_139378192 58.912 SEC16A
SEC16 homolog A (S. cerevisiae)
chr20_+_57556322 58.895 TH1L
TH1-like (Drosophila)
chrX_-_16887974 58.408 NM_001198719
RBBP7
retinoblastoma binding protein 7
chr2_+_190526124 58.398 NM_019048
ASNSD1
asparagine synthetase domain containing 1
chr17_+_40761357 58.397 NM_001070
TUBG1
tubulin, gamma 1
chr16_+_4475804 58.147 NM_001135110
NM_005147
DNAJA3

DnaJ (Hsp40) homolog, subfamily A, member 3

chr4_+_146019368 58.122 ABCE1
ATP-binding cassette, sub-family E (OABP), member 1
chr5_+_10250370 57.992 CCT5
chaperonin containing TCP1, subunit 5 (epsilon)
chr5_+_52095929 57.698 PELO
pelota homolog (Drosophila)
chr6_-_31774725 57.472 NM_021177
LSM2
LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr11_-_77850670 57.215 ALG8
asparagine-linked glycosylation 8, alpha-1,3-glucosyltransferase homolog (S. cerevisiae)
chr11_-_77850687 57.131 NM_001007027
NM_024079
ALG8

asparagine-linked glycosylation 8, alpha-1,3-glucosyltransferase homolog (S. cerevisiae)

chr14_-_102553344 57.108 HSP90AA1
heat shock protein 90kDa alpha (cytosolic), class A member 1
chr19_+_59056017 56.936 TRIM28
tripartite motif containing 28
chr1_+_35734558 56.767 NM_005095
ZMYM4
zinc finger, MYM-type 4
chr20_+_25176333 56.681 NM_001114089
NM_001247
ENTPD6

ectonucleoside triphosphate diphosphohydrolase 6 (putative)

chr1_+_100731696 56.272 NM_001130841
NM_003729
RTCD1

RNA terminal phosphate cyclase domain 1

chr11_+_108535773 56.113 NM_004398
DDX10
DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
chr3_+_100428361 55.853 NM_001195478
TFG
TRK-fused gene
chr9_+_131451519 55.623 SET
SET nuclear oncogene
chr1_-_8939150 55.489 NM_001428
ENO1
enolase 1, (alpha)
chr19_+_8509869 55.467 HNRNPM
heterogeneous nuclear ribonucleoprotein M
chr5_+_10250403 55.345 CCT5
chaperonin containing TCP1, subunit 5 (epsilon)
chr17_-_3627073 55.281 ITGAE
integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
chr20_+_57556295 54.942 NM_198976
TH1L
TH1-like (Drosophila)
chr2_-_150444236 54.856 MMADHC
methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria
chr19_-_55919324 54.540 NM_014501
UBE2S
ubiquitin-conjugating enzyme E2S
chr9_-_124921981 54.424 NDUFA8
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa
chr6_-_42981656 54.169 MEA1
male-enhanced antigen 1
chr10_-_71993070 54.148 NM_021129
PPA1
pyrophosphatase (inorganic) 1
chr19_+_8509802 54.131 NM_005968
NM_031203
HNRNPM

heterogeneous nuclear ribonucleoprotein M

chr3_-_150320949 53.920 SERP1
stress-associated endoplasmic reticulum protein 1
chr17_+_3572089 53.659 NM_001014764
NM_031298
TMEM93

transmembrane protein 93

chr13_+_76123885 53.495 NM_006002
UCHL3
ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
chr1_+_91966365 53.012 NM_001134419
NM_003503
CDC7

cell division cycle 7 homolog (S. cerevisiae)

chr19_+_984316 52.934 NM_024100
WDR18
WD repeat domain 18
chr1_+_41445359 52.622 CTPS
CTP synthase
chr4_+_146019486 52.601 ABCE1
ATP-binding cassette, sub-family E (OABP), member 1
chr7_+_100027404 52.591 MEPCE
methylphosphate capping enzyme
chr19_-_10305600 52.559 DNMT1
DNA (cytosine-5-)-methyltransferase 1
chr14_+_67827042 52.553 EIF2S1
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
chr6_+_24667262 52.549 NM_001160094
NM_018473
ACOT13

acyl-CoA thioesterase 13

chr19_+_36236460 52.442 NM_172341
PSENEN
presenilin enhancer 2 homolog (C. elegans)
chr2_-_150444219 52.323 MMADHC
methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria
chr21_-_33651324 52.148 NM_018944
MIS18A
MIS18 kinetochore protein homolog A (S. pombe)
chr16_+_67063035 52.039 NM_001755
NM_022845
CBFB

core-binding factor, beta subunit

chr19_+_531688 51.921 NM_004359
CDC34
cell division cycle 34 homolog (S. cerevisiae)
chr9_+_131451470 51.886 NM_003011
SET
SET nuclear oncogene
chr10_-_16859336 51.848 RSU1
Ras suppressor protein 1
chr4_-_1242882 51.736 NM_001012614
NM_001328
CTBP1

C-terminal binding protein 1

chr3_-_48647052 51.708 UQCRC1
ubiquinol-cytochrome c reductase core protein I
chr2_+_216974120 51.359 XRCC5
X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
chr3_-_48647085 50.851 NM_003365
UQCRC1
ubiquinol-cytochrome c reductase core protein I
chr7_-_102119307 50.830 NM_006234
POLR2J
polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa
chr3_-_112280764 50.749 ATG3
ATG3 autophagy related 3 homolog (S. cerevisiae)
chr10_+_99185977 50.738 PGAM1
phosphoglycerate mutase 1 (brain)
chr5_-_179050675 50.729 NM_005520
HNRNPH1
heterogeneous nuclear ribonucleoprotein H1 (H)
chr2_-_150444285 50.682 NM_015702
MMADHC
methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria
chr3_-_49066813 50.593 IMPDH2
IMP (inosine 5'-monophosphate) dehydrogenase 2
chr6_+_32936400 50.587 NM_005104
BRD2
bromodomain containing 2
chr3_-_49066760 50.571 IMPDH2
IMP (inosine 5'-monophosphate) dehydrogenase 2
chr15_-_65477645 50.525 CLPX
ClpX caseinolytic peptidase X homolog (E. coli)
chr19_+_59055866 50.494 TRIM28
tripartite motif containing 28
chr5_+_218428 50.419 SDHA
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
chr20_+_55926144 50.368 NM_003610
RAE1
RAE1 RNA export 1 homolog (S. pombe)
chr4_+_57845095 50.143 NM_000938
POLR2B
polymerase (RNA) II (DNA directed) polypeptide B, 140kDa
chr17_-_47755340 50.110 NM_001007226
NM_001007227
NM_001007228
NM_001007229
NM_001007230
NM_003563
SPOP





speckle-type POZ protein





chr20_+_55926299 49.892 RAE1
RAE1 RNA export 1 homolog (S. pombe)
chr8_-_109260930 49.621 EIF3E
eukaryotic translation initiation factor 3, subunit E
chr2_+_101179395 49.607 NM_024065
PDCL3
phosducin-like 3
chr5_+_10250377 49.534 CCT5
chaperonin containing TCP1, subunit 5 (epsilon)
chr19_-_1095380 49.496 NM_002695
POLR2E
polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
chr8_-_109260940 49.283 NM_001568
EIF3E
eukaryotic translation initiation factor 3, subunit E
chr19_-_14529853 49.100 DDX39A
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
chr4_+_57845057 48.978 POLR2B
polymerase (RNA) II (DNA directed) polypeptide B, 140kDa
chr19_+_8509594 48.852 HNRNPM
heterogeneous nuclear ribonucleoprotein M
chr5_-_179050635 48.401 HNRNPH1
heterogeneous nuclear ribonucleoprotein H1 (H)
chr19_-_1095316 48.395 POLR2E
polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
chrX_-_129299680 48.258 AIFM1
apoptosis-inducing factor, mitochondrion-associated, 1
chr1_+_100731797 48.059 RTCD1
RNA terminal phosphate cyclase domain 1
chr7_-_105752974 48.049 NM_006754
SYPL1
synaptophysin-like 1
chr14_-_102605974 47.683 NM_001017963
HSP90AA1
heat shock protein 90kDa alpha (cytosolic), class A member 1
chr4_+_57845018 47.610 POLR2B
polymerase (RNA) II (DNA directed) polypeptide B, 140kDa
chr1_-_19536741 47.574 NM_020765
UBR4
ubiquitin protein ligase E3 component n-recognin 4
chr5_-_133561551 47.456 PPP2CA
protein phosphatase 2, catalytic subunit, alpha isozyme
chr19_+_11071583 47.377 NM_001128844
NM_003072
SMARCA4

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4

chr20_+_55926585 47.169 NM_001015885
RAE1
RAE1 RNA export 1 homolog (S. pombe)
chr7_-_42971730 46.864 PSMA2
proteasome (prosome, macropain) subunit, alpha type, 2
chr2_+_216974101 46.853 XRCC5
X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
chr11_+_65101224 46.756 NM_006268
DPF2
D4, zinc and double PHD fingers family 2
chr7_+_100303673 46.328 NM_005837
POP7
processing of precursor 7, ribonuclease P/MRP subunit (S. cerevisiae)
chr19_-_1095373 46.212 POLR2E
polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
chr2_-_132250050 45.912 NM_001085365
MZT2A
mitotic spindle organizing protein 2A
chr17_+_7210317 45.827 NM_001143760
EIF5A
eukaryotic translation initiation factor 5A
chr19_+_39421347 45.684 NM_033362
MRPS12
mitochondrial ribosomal protein S12
chr6_-_159065739 45.240 NM_006519
DYNLT1
dynein, light chain, Tctex-type 1
chrX_-_129299629 45.206 AIFM1
apoptosis-inducing factor, mitochondrion-associated, 1
chr7_+_100027253 45.097 NM_019606
MEPCE
methylphosphate capping enzyme
chr17_+_35849997 44.742 DUSP14
dual specificity phosphatase 14
chr19_+_59055826 44.721 NM_005762
TRIM28
tripartite motif containing 28
chr8_+_145137496 44.535 GPAA1
glycosylphosphatidylinositol anchor attachment protein 1 homolog (yeast)
chr2_+_86333304 44.435 NM_017952
PTCD3
Pentatricopeptide repeat domain 3
chr12_+_110906203 44.361 NM_013300
C12orf24
chromosome 12 open reading frame 24
chr2_+_242255365 44.303 SEPT2
septin 2
chr12_-_27091207 44.111 NM_018164
ASUN
asunder, spermatogenesis regulator homolog (Drosphila)
chr1_-_155231941 44.048 SCAMP3
secretory carrier membrane protein 3
chr13_+_27998614 43.974 NM_002097
GTF3A
general transcription factor IIIA
chr9_+_131451823 43.887 SET
SET nuclear oncogene
chr3_+_133292404 43.838 NM_001134422
NM_017548
CDV3

CDV3 homolog (mouse)

chr17_-_56084611 43.766 SRSF1
serine/arginine-rich splicing factor 1
chr21_-_38445389 43.519 NM_153682
PIGP
phosphatidylinositol glycan anchor biosynthesis, class P
chr19_-_10305645 43.374 NM_001130823
NM_001379
DNMT1

DNA (cytosine-5-)-methyltransferase 1

chr1_+_91966653 43.352 NM_001134420
CDC7
cell division cycle 7 homolog (S. cerevisiae)
chr1_+_167189948 43.341 NM_001198786
NM_002697
POU2F1

POU class 2 homeobox 1

chr12_-_27090877 43.197 ASUN
asunder, spermatogenesis regulator homolog (Drosphila)
chr19_+_39109684 43.116 NM_013234
EIF3K
eukaryotic translation initiation factor 3, subunit K
chr17_+_35849950 42.807 NM_007026
DUSP14
dual specificity phosphatase 14
chr19_+_11071792 42.774 NM_001128849
SMARCA4
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
chr18_-_54305657 42.548 TXNL1
thioredoxin-like 1
chr3_-_107809754 42.524 NM_001777
NM_198793
CD47

CD47 molecule

chr10_+_60028885 42.389 NM_018464
CISD1
CDGSH iron sulfur domain 1
chr17_+_7155371 42.375 NM_203415
NM_015362
NM_203413
NM_203414
C17orf81



chromosome 17 open reading frame 81



chr15_-_90777191 42.366 NM_006384
CIB1
calcium and integrin binding 1 (calmyrin)
chr14_-_54908035 42.297 NM_005776
CNIH
cornichon homolog (Drosophila)
chr21_-_38444814 42.286 NM_153681
PIGP
phosphatidylinositol glycan anchor biosynthesis, class P
chr2_-_198364997 42.153 NM_199440
HSPD1
heat shock 60kDa protein 1 (chaperonin)
chr3_-_182698291 42.147 NM_020640
DCUN1D1
DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)
chr14_-_102553386 42.070 NM_005348
HSP90AA1
heat shock protein 90kDa alpha (cytosolic), class A member 1
chr17_+_7486964 41.998 NM_004870
MPDU1
mannose-P-dolichol utilization defect 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.77 5.24e-56 GO:0044260 cellular macromolecule metabolic process
1.58 1.03e-55 GO:0044237 cellular metabolic process
1.63 2.47e-44 GO:0043170 macromolecule metabolic process
1.46 2.23e-43 GO:0008152 metabolic process
2.08 4.01e-43 GO:0090304 nucleic acid metabolic process
1.93 3.36e-42 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.48 3.86e-39 GO:0044238 primary metabolic process
1.79 3.45e-37 GO:0034641 cellular nitrogen compound metabolic process
1.77 1.45e-36 GO:0006807 nitrogen compound metabolic process
1.24 3.20e-34 GO:0009987 cellular process
2.02 1.07e-30 GO:0010467 gene expression
2.02 7.52e-29 GO:0016070 RNA metabolic process
2.71 6.71e-25 GO:0006396 RNA processing
2.76 1.14e-21 GO:0016071 mRNA metabolic process
1.70 1.41e-21 GO:0044267 cellular protein metabolic process
1.66 2.54e-21 GO:0071841 cellular component organization or biogenesis at cellular level
3.34 3.20e-20 GO:0008380 RNA splicing
1.89 4.63e-20 GO:0006996 organelle organization
3.90 8.78e-20 GO:0000375 RNA splicing, via transesterification reactions
3.88 5.37e-19 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
3.88 5.37e-19 GO:0000398 nuclear mRNA splicing, via spliceosome
1.63 2.01e-18 GO:0071842 cellular component organization at cellular level
1.83 2.23e-18 GO:0034645 cellular macromolecule biosynthetic process
2.93 2.69e-18 GO:0006397 mRNA processing
1.82 5.25e-18 GO:0009059 macromolecule biosynthetic process
1.52 7.62e-18 GO:0071840 cellular component organization or biogenesis
2.50 3.19e-17 GO:0000278 mitotic cell cycle
2.35 4.12e-17 GO:0022403 cell cycle phase
2.21 3.93e-16 GO:0046907 intracellular transport
1.50 8.00e-16 GO:0016043 cellular component organization
2.03 8.19e-16 GO:0007049 cell cycle
2.17 1.67e-15 GO:0022402 cell cycle process
1.60 6.68e-15 GO:0044249 cellular biosynthetic process
1.52 1.08e-14 GO:0019538 protein metabolic process
1.55 3.17e-13 GO:0009058 biosynthetic process
1.83 4.36e-13 GO:0051641 cellular localization
2.28 7.27e-13 GO:0006259 DNA metabolic process
1.87 2.80e-12 GO:0051649 establishment of localization in cell
2.21 4.94e-12 GO:0051276 chromosome organization
3.93 5.97e-12 GO:0006403 RNA localization
2.46 6.73e-12 GO:0000279 M phase
3.97 8.90e-12 GO:0050657 nucleic acid transport
3.97 8.90e-12 GO:0050658 RNA transport
3.97 8.90e-12 GO:0051236 establishment of RNA localization
1.99 2.55e-11 GO:0033554 cellular response to stress
4.02 5.72e-11 GO:0051028 mRNA transport
2.66 1.62e-10 GO:0006412 translation
2.68 1.84e-10 GO:0000087 M phase of mitotic cell cycle
3.50 5.67e-10 GO:0015931 nucleobase, nucleoside, nucleotide and nucleic acid transport
4.84 6.84e-10 GO:0006405 RNA export from nucleus
2.63 7.22e-10 GO:0048285 organelle fission
2.21 9.86e-10 GO:0006974 response to DNA damage stimulus
2.34 2.03e-09 GO:0016032 viral reproduction
2.59 5.13e-09 GO:0000280 nuclear division
2.59 5.13e-09 GO:0007067 mitosis
4.18 9.77e-09 GO:0051168 nuclear export
1.67 1.55e-08 GO:0033036 macromolecule localization
2.16 1.87e-08 GO:0034621 cellular macromolecular complex subunit organization
2.52 1.93e-08 GO:0051329 interphase of mitotic cell cycle
3.46 2.18e-08 GO:0045333 cellular respiration
2.02 2.31e-08 GO:0009057 macromolecule catabolic process
2.40 2.53e-08 GO:0006281 DNA repair
2.10 2.74e-08 GO:0044265 cellular macromolecule catabolic process
2.99 3.73e-08 GO:0051169 nuclear transport
2.47 4.27e-08 GO:0051325 interphase
1.68 7.79e-08 GO:0044085 cellular component biogenesis
2.95 9.25e-08 GO:0006913 nucleocytoplasmic transport
1.82 9.58e-08 GO:0015031 protein transport
4.64 1.02e-07 GO:0006406 mRNA export from nucleus
1.80 1.54e-07 GO:0045184 establishment of protein localization
1.69 4.79e-07 GO:0008104 protein localization
2.27 7.05e-07 GO:0051301 cell division
1.65 7.90e-07 GO:0044248 cellular catabolic process
1.72 8.40e-07 GO:0032774 RNA biosynthetic process
1.78 9.82e-07 GO:0043933 macromolecular complex subunit organization
1.48 1.28e-06 GO:0043412 macromolecule modification
2.66 1.40e-06 GO:0071843 cellular component biogenesis at cellular level
3.60 1.40e-06 GO:0022904 respiratory electron transport chain
2.37 1.73e-06 GO:0006366 transcription from RNA polymerase II promoter
2.69 2.55e-06 GO:0022613 ribonucleoprotein complex biogenesis
2.17 6.66e-06 GO:0034622 cellular macromolecular complex assembly
1.47 8.14e-06 GO:0006464 protein modification process
4.85 3.28e-05 GO:0006413 translational initiation
2.11 3.29e-05 GO:0044419 interspecies interaction between organisms
1.74 4.60e-05 GO:0071844 cellular component assembly at cellular level
1.94 6.95e-05 GO:0006325 chromatin organization
1.50 7.84e-05 GO:0009056 catabolic process
3.69 9.87e-05 GO:0006200 ATP catabolic process
1.75 9.90e-05 GO:0065003 macromolecular complex assembly
1.79 1.11e-04 GO:0051726 regulation of cell cycle
2.24 1.28e-04 GO:0034660 ncRNA metabolic process
1.59 1.42e-04 GO:0022607 cellular component assembly
2.45 1.54e-04 GO:0006457 protein folding
1.65 1.65e-04 GO:0006351 transcription, DNA-dependent
1.86 1.83e-04 GO:0070727 cellular macromolecule localization
1.85 2.94e-04 GO:0034613 cellular protein localization
2.76 3.71e-04 GO:0022900 electron transport chain
3.62 5.80e-04 GO:0031124 mRNA 3'-end processing
1.95 6.14e-04 GO:0006886 intracellular protein transport
2.88 9.67e-04 GO:0000086 G2/M transition of mitotic cell cycle
2.02 1.02e-03 GO:0070647 protein modification by small protein conjugation or removal
3.96 1.12e-03 GO:0007051 spindle organization
3.26 1.16e-03 GO:0000956 nuclear-transcribed mRNA catabolic process
3.61 1.21e-03 GO:0006368 transcription elongation from RNA polymerase II promoter
2.16 1.26e-03 GO:0016567 protein ubiquitination
1.29 1.32e-03 GO:0051234 establishment of localization
1.91 1.65e-03 GO:0006091 generation of precursor metabolites and energy
2.10 1.73e-03 GO:0032446 protein modification by small protein conjugation
2.10 2.37e-03 GO:0015980 energy derivation by oxidation of organic compounds
1.94 2.56e-03 GO:0016568 chromatin modification
2.32 2.77e-03 GO:0034470 ncRNA processing
2.45 3.06e-03 GO:0022415 viral reproductive process
2.48 3.08e-03 GO:0000226 microtubule cytoskeleton organization
2.07 3.34e-03 GO:0010608 posttranscriptional regulation of gene expression
4.08 3.49e-03 GO:0006369 termination of RNA polymerase II transcription
1.94 3.51e-03 GO:0010564 regulation of cell cycle process
1.57 3.71e-03 GO:0008219 cell death
3.26 3.83e-03 GO:0006302 double-strand break repair
1.28 3.92e-03 GO:0006810 transport
3.03 4.70e-03 GO:0006402 mRNA catabolic process
1.56 4.72e-03 GO:0016265 death
4.50 4.91e-03 GO:0000245 spliceosome assembly
2.38 5.59e-03 GO:0006417 regulation of translation
3.73 6.15e-03 GO:0006119 oxidative phosphorylation
2.51 7.91e-03 GO:0007005 mitochondrion organization
2.51 7.91e-03 GO:0019058 viral infectious cycle
1.50 8.65e-03 GO:0032268 regulation of cellular protein metabolic process
1.68 8.72e-03 GO:0071822 protein complex subunit organization
2.16 9.11e-03 GO:0009203 ribonucleoside triphosphate catabolic process
2.16 9.11e-03 GO:0009207 purine ribonucleoside triphosphate catabolic process
1.92 9.65e-03 GO:0051603 proteolysis involved in cellular protein catabolic process
2.15 1.03e-02 GO:0009146 purine nucleoside triphosphate catabolic process
2.06 1.05e-02 GO:0051248 negative regulation of protein metabolic process
2.39 1.06e-02 GO:0071103 DNA conformation change
2.52 1.08e-02 GO:0046034 ATP metabolic process
1.53 1.10e-02 GO:0010605 negative regulation of macromolecule metabolic process
1.92 1.19e-02 GO:0043632 modification-dependent macromolecule catabolic process
1.60 1.23e-02 GO:0012501 programmed cell death
3.04 1.24e-02 GO:0031123 RNA 3'-end processing
2.55 1.26e-02 GO:0042254 ribosome biogenesis
1.86 1.32e-02 GO:0030163 protein catabolic process
2.85 1.34e-02 GO:0006364 rRNA processing
3.90 1.45e-02 GO:0000070 mitotic sister chromatid segregation
2.12 1.47e-02 GO:0009143 nucleoside triphosphate catabolic process
2.12 1.47e-02 GO:0009154 purine ribonucleotide catabolic process
1.88 1.70e-02 GO:0044257 cellular protein catabolic process
2.89 1.79e-02 GO:0000236 mitotic prometaphase
1.95 1.83e-02 GO:0009199 ribonucleoside triphosphate metabolic process
2.10 1.86e-02 GO:0009261 ribonucleotide catabolic process
2.66 1.90e-02 GO:0007059 chromosome segregation
2.96 1.92e-02 GO:0006839 mitochondrial transport
2.05 1.96e-02 GO:0032269 negative regulation of cellular protein metabolic process
2.01 2.02e-02 GO:0009166 nucleotide catabolic process
1.23 2.05e-02 GO:0051179 localization
1.90 2.14e-02 GO:0019941 modification-dependent protein catabolic process
1.31 2.28e-02 GO:0048523 negative regulation of cellular process
1.89 2.35e-02 GO:0033043 regulation of organelle organization
1.46 2.47e-02 GO:0051246 regulation of protein metabolic process
2.30 2.49e-02 GO:0010498 proteasomal protein catabolic process
2.30 2.49e-02 GO:0043161 proteasomal ubiquitin-dependent protein catabolic process
2.68 2.58e-02 GO:0006414 translational elongation
1.90 2.63e-02 GO:0006511 ubiquitin-dependent protein catabolic process
3.49 3.09e-02 GO:0050434 positive regulation of viral transcription
1.88 3.17e-02 GO:0009150 purine ribonucleotide metabolic process
4.15 3.24e-02 GO:0009060 aerobic respiration
2.01 3.37e-02 GO:0072523 purine-containing compound catabolic process
2.70 3.50e-02 GO:0016072 rRNA metabolic process
1.57 3.56e-02 GO:0006915 apoptosis
1.92 3.67e-02 GO:0009205 purine ribonucleoside triphosphate metabolic process
3.63 3.67e-02 GO:0000819 sister chromatid segregation
2.37 3.69e-02 GO:0006310 DNA recombination
2.56 3.79e-02 GO:0006401 RNA catabolic process
1.85 4.07e-02 GO:0009259 ribonucleotide metabolic process
2.01 4.14e-02 GO:0006195 purine nucleotide catabolic process
1.89 4.36e-02 GO:0009141 nucleoside triphosphate metabolic process
1.90 4.88e-02 GO:0009144 purine nucleoside triphosphate metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.33 4.35e-77 GO:0044424 intracellular part
1.31 1.02e-72 GO:0005622 intracellular
1.45 7.27e-71 GO:0043227 membrane-bounded organelle
1.45 9.47e-71 GO:0043231 intracellular membrane-bounded organelle
1.40 1.03e-70 GO:0043229 intracellular organelle
1.40 3.96e-70 GO:0043226 organelle
1.65 1.15e-59 GO:0044446 intracellular organelle part
1.64 1.04e-58 GO:0044422 organelle part
2.13 1.87e-48 GO:0044428 nuclear part
1.40 6.45e-47 GO:0005737 cytoplasm
1.57 1.93e-46 GO:0005634 nucleus
1.76 4.05e-42 GO:0032991 macromolecular complex
1.95 3.33e-38 GO:0031974 membrane-enclosed lumen
1.97 7.74e-38 GO:0070013 intracellular organelle lumen
1.94 3.01e-36 GO:0043233 organelle lumen
2.07 1.96e-35 GO:0031981 nuclear lumen
1.45 3.26e-32 GO:0044444 cytoplasmic part
2.19 3.47e-30 GO:0005654 nucleoplasm
1.79 3.44e-23 GO:0005829 cytosol
1.62 3.76e-22 GO:0043234 protein complex
2.73 9.55e-22 GO:0030529 ribonucleoprotein complex
1.57 2.45e-17 GO:0043228 non-membrane-bounded organelle
1.57 2.45e-17 GO:0043232 intracellular non-membrane-bounded organelle
1.82 7.84e-15 GO:0005739 mitochondrion
2.17 1.23e-14 GO:0031967 organelle envelope
2.47 3.33e-14 GO:0044427 chromosomal part
2.13 5.34e-14 GO:0031975 envelope
1.08 1.53e-13 GO:0044464 cell part
1.08 1.61e-13 GO:0005623 cell
2.29 2.11e-13 GO:0005694 chromosome
3.80 1.87e-11 GO:0044455 mitochondrial membrane part
2.03 1.00e-10 GO:0044429 mitochondrial part
1.89 1.58e-08 GO:0044451 nucleoplasm part
2.08 1.82e-08 GO:0005730 nucleolus
2.87 3.15e-08 GO:0005819 spindle
1.44 2.66e-07 GO:0031090 organelle membrane
2.25 2.85e-07 GO:0019866 organelle inner membrane
3.07 3.60e-07 GO:0005681 spliceosomal complex
2.30 4.02e-07 GO:0005743 mitochondrial inner membrane
2.06 4.78e-07 GO:0031966 mitochondrial membrane
1.83 6.71e-07 GO:0015630 microtubule cytoskeleton
2.02 6.82e-07 GO:0005740 mitochondrial envelope
2.43 1.51e-06 GO:0005635 nuclear envelope
3.80 1.05e-05 GO:0000922 spindle pole
3.80 1.05e-05 GO:0070469 respiratory chain
2.33 1.69e-05 GO:0000785 chromatin
2.73 2.50e-05 GO:0000775 chromosome, centromeric region
2.08 2.65e-05 GO:0005815 microtubule organizing center
3.30 5.37e-05 GO:0046930 pore complex
3.74 6.27e-05 GO:0005746 mitochondrial respiratory chain
2.48 9.16e-05 GO:0044454 nuclear chromosome part
3.47 1.28e-04 GO:0005643 nuclear pore
2.28 1.67e-04 GO:0000228 nuclear chromosome
3.11 1.80e-04 GO:0000776 kinetochore
3.18 3.71e-04 GO:0071013 catalytic step 2 spliceosome
2.19 5.39e-04 GO:0005813 centrosome
3.17 1.23e-03 GO:0000777 condensed chromosome kinetochore
2.14 1.37e-03 GO:0016604 nuclear body
2.46 1.56e-03 GO:0000793 condensed chromosome
2.96 3.78e-03 GO:0000779 condensed chromosome, centromeric region
2.19 3.90e-03 GO:0005840 ribosome
1.96 7.41e-03 GO:0005759 mitochondrial matrix
4.56 1.30e-02 GO:0044452 nucleolar part
3.23 1.73e-02 GO:0034708 methyltransferase complex
3.23 1.73e-02 GO:0035097 histone methyltransferase complex
1.34 1.81e-02 GO:0012505 endomembrane system
2.38 1.90e-02 GO:0016607 nuclear speck
6.14 2.18e-02 GO:0005665 DNA-directed RNA polymerase II, core complex
3.45 2.68e-02 GO:0016469 proton-transporting two-sector ATPase complex
2.22 3.45e-02 GO:0000151 ubiquitin ligase complex
6.85 3.59e-02 GO:0005868 cytoplasmic dynein complex
2.19 4.45e-02 GO:0031965 nuclear membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.49 2.94e-55 GO:0005515 protein binding
2.48 7.50e-27 GO:0003723 RNA binding
1.17 4.00e-22 GO:0005488 binding
1.43 1.35e-12 GO:0003676 nucleic acid binding
1.54 1.60e-12 GO:0000166 nucleotide binding
1.28 2.84e-10 GO:0003824 catalytic activity
1.49 8.98e-06 GO:0005524 ATP binding
1.48 9.73e-06 GO:0030554 adenyl nucleotide binding
1.71 9.82e-06 GO:0016462 pyrophosphatase activity
1.48 1.05e-05 GO:0032559 adenyl ribonucleotide binding
1.70 1.23e-05 GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
1.69 1.53e-05 GO:0016817 hydrolase activity, acting on acid anhydrides
3.03 1.65e-05 GO:0051082 unfolded protein binding
1.42 1.85e-05 GO:0035639 purine ribonucleoside triphosphate binding
1.41 2.88e-05 GO:0032553 ribonucleotide binding
1.41 2.88e-05 GO:0032555 purine ribonucleotide binding
1.41 2.91e-05 GO:0017076 purine nucleotide binding
1.66 1.19e-04 GO:0017111 nucleoside-triphosphatase activity
3.24 1.86e-04 GO:0008135 translation factor activity, nucleic acid binding
4.04 2.06e-04 GO:0003743 translation initiation factor activity
2.83 3.73e-04 GO:0016779 nucleotidyltransferase activity
1.94 6.64e-04 GO:0016887 ATPase activity
1.76 1.99e-03 GO:0016874 ligase activity
3.99 2.68e-03 GO:0003899 DNA-directed RNA polymerase activity
3.99 2.68e-03 GO:0034062 RNA polymerase activity
11.41 3.50e-03 GO:0017070 U6 snRNA binding
2.15 8.42e-03 GO:0003682 chromatin binding
1.92 1.30e-02 GO:0016881 acid-amino acid ligase activity
3.20 1.40e-02 GO:0003697 single-stranded DNA binding
2.10 1.86e-02 GO:0043566 structure-specific DNA binding
1.85 1.96e-02 GO:0016879 ligase activity, forming carbon-nitrogen bonds
2.00 2.00e-02 GO:0004842 ubiquitin-protein ligase activity
2.21 2.71e-02 GO:0004518 nuclease activity
1.94 3.32e-02 GO:0019787 small conjugating protein ligase activity
2.25 3.49e-02 GO:0004386 helicase activity