Motif ID: ONECUT1,2.p2

Z-value: 1.167


Transcription factors associated with ONECUT1,2.p2:

Gene SymbolEntrez IDGene Name
ONECUT1 3175 one cut homeobox 1
ONECUT2 9480 one cut homeobox 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ONECUT1chr15_-_530820870.243.7e-04Click!
ONECUT2chr18_+_551027770.018.5e-01Click!


Activity profile for motif ONECUT1,2.p2.

activity profile for motif ONECUT1,2.p2


Sorted Z-values histogram for motif ONECUT1,2.p2

Sorted Z-values for motif ONECUT1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ONECUT1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_-_149792370 23.356 NM_001025158
NM_001025159
NM_004355
CD74


CD74 molecule, major histocompatibility complex, class II invariant chain


chr5_-_149792276 22.253 CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chr22_+_23054862 21.123 IGLV3-21
IGLJ3
IGLC1
immunoglobulin lambda variable 3-21
immunoglobulin lambda joining 3
immunoglobulin lambda constant 1 (Mcg marker)
chr2_-_89165652 19.592


chr6_+_33043702 17.127 NM_002121
HLA-DPB1
major histocompatibility complex, class II, DP beta 1
chr12_-_91573264 12.204 NM_133503
DCN
decorin
chr1_+_198608136 10.708 NM_002838
NM_080921
NM_080923
PTPRC


protein tyrosine phosphatase, receptor type, C


chr7_+_23286420 10.501 GPNMB
glycoprotein (transmembrane) nmb
chr7_+_23286384 10.258 GPNMB
glycoprotein (transmembrane) nmb
chr1_-_151345156 10.167 NM_003944
SELENBP1
selenium binding protein 1
chr10_-_98031154 10.006 NM_001114094
NM_013314
BLNK

B-cell linker

chr4_-_100212085 9.978 NM_000667
ADH1A
alcohol dehydrogenase 1A (class I), alpha polypeptide
chr1_+_198608244 9.940 PTPRC
protein tyrosine phosphatase, receptor type, C
chr18_-_47814691 9.733 NM_001101654
NM_014593
CXXC1

CXXC finger protein 1

chr15_-_43513024 9.701 EPB42
erythrocyte membrane protein band 4.2
chr1_+_198608216 8.660 PTPRC
protein tyrosine phosphatase, receptor type, C
chr15_-_43513234 8.573 NM_000119
NM_001114134
EPB42

erythrocyte membrane protein band 4.2

chr7_-_14025826 8.369 NM_001163150
NM_001163151
NM_001163152
ETV1


ets variant 1


chr8_-_82395401 8.331 NM_001442
FABP4
fatty acid binding protein 4, adipocyte
chr3_-_141747434 8.277 NM_001178141
NM_001178142
NM_006286
TFDP2


transcription factor Dp-2 (E2F dimerization partner 2)


chr15_-_43513196 8.047 EPB42
erythrocyte membrane protein band 4.2
chr7_+_23286386 8.004 GPNMB
glycoprotein (transmembrane) nmb
chr6_-_32920812 7.996 NM_006120
HLA-DMA
major histocompatibility complex, class II, DM alpha
chr12_-_15038724 7.736 NM_000900
NM_001190839
MGP

matrix Gla protein

chr1_+_111413820 7.562 NM_001040033
CD53
CD53 molecule
chr12_-_91576579 7.127 DCN
decorin
chr7_+_23286277 6.981 NM_001005340
NM_002510
GPNMB

glycoprotein (transmembrane) nmb

chr14_-_23426356 6.768 HAUS4
HAUS augmin-like complex, subunit 4
chr1_+_192605267 6.732 NM_002927
NM_144766
RGS13

regulator of G-protein signaling 13

chr15_-_60919642 6.552 NM_002943
NM_134260
RORA

RAR-related orphan receptor A

chr6_+_31913852 6.389 CFB
complement factor B
chr8_-_86290333 6.077 NM_001128829
NM_001128830
NM_001128831
NM_001738
CA1



carbonic anhydrase I



chr4_-_155511838 5.853 NM_000508
NM_021871
FGA

fibrinogen alpha chain

chr4_-_144940439 5.815 NM_002100
GYPB
glycophorin B (MNS blood group)
chr13_-_46756295 5.753 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr12_-_91505215 5.729 LUM
lumican
chr7_+_23286390 5.533 GPNMB
glycoprotein (transmembrane) nmb
chr16_+_81812897 5.487 NM_002661
PLCG2
phospholipase C, gamma 2 (phosphatidylinositol-specific)
chr7_-_100239136 5.470 NM_003227
TFR2
transferrin receptor 2
chr9_-_95244634 5.306 ASPN
asporin
chr6_+_32407618 5.298 NM_019111
HLA-DRA
major histocompatibility complex, class II, DR alpha
chr7_-_112726143 5.259 NM_001146266
NM_001146267
GPR85

G protein-coupled receptor 85

chr11_+_17332454 5.208


chr7_+_129906702 5.035 NM_001869
CPA2
carboxypeptidase A2 (pancreatic)
chrX_-_131573638 5.030 NM_018388
NM_133486
MBNL3

muscleblind-like 3 (Drosophila)

chr17_+_28268622 4.946 NM_198529
EFCAB5
EF-hand calcium binding domain 5
chr9_-_95244750 4.925 NM_001193335
NM_017680
ASPN

asporin

chr19_-_39826676 4.905 NM_004877
GMFG
glia maturation factor, gamma
chr3_-_49459870 4.903 AMT
aminomethyltransferase
chr5_+_139876504 4.830 ANKHD1
ankyrin repeat and KH domain containing 1
chr15_+_93443418 4.780 NM_001042572
NM_001271
CHD2

chromodomain helicase DNA binding protein 2

chr16_+_81812899 4.755 PLCG2
phospholipase C, gamma 2 (phosphatidylinositol-specific)
chr14_-_23426265 4.605 NM_001166269
NM_001166270
NM_017815
HAUS4


HAUS augmin-like complex, subunit 4


chr10_+_7745341 4.551 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr10_+_7745354 4.537 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr3_-_49460110 4.533 NM_000481
NM_001164710
NM_001164711
NM_001164712
AMT



aminomethyltransferase



chr6_+_30227335 4.497 HLA-L
major histocompatibility complex, class I, L, pseudogene
chrX_-_15288172 4.398 NM_001031739
NM_001168530
NM_024087
ASB9


ankyrin repeat and SOCS box containing 9


chr12_-_91576805 4.395 NM_001920
DCN
decorin
chr5_+_115898218 4.375


chr10_+_7745229 4.346 NM_002216
ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr6_+_31895201 4.321 NM_000063
NM_001145903
C2

complement component 2

chr6_+_16143281 4.320 MYLIP
myosin regulatory light chain interacting protein
chr5_+_68667280 4.252 NM_133339
RAD17
RAD17 homolog (S. pombe)
chr10_+_7745325 4.206 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chrX_+_49832214 4.152 NM_000084
CLCN5
chloride channel 5
chr10_+_7745284 4.095 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr4_-_116034932 3.941 NM_022569
NDST4
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4
chr6_+_74171610 3.931 MTO1
mitochondrial translation optimization 1 homolog (S. cerevisiae)
chr6_+_56954985 3.873 ZNF451
zinc finger protein 451
chr6_+_56954978 3.858 ZNF451
zinc finger protein 451
chr11_+_113775517 3.813 NM_006028
HTR3B
5-hydroxytryptamine (serotonin) receptor 3B
chr19_+_9296269 3.762 NM_175883
OR7D2
olfactory receptor, family 7, subfamily D, member 2
chr13_-_46756326 3.753 NM_002298
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr22_+_40573879 3.741 NM_001162501
NM_015088
TNRC6B

trinucleotide repeat containing 6B

chr9_-_138853146 3.707 NM_016172
UBAC1
UBA domain containing 1
chr3_-_170744767 3.685 NM_000340
SLC2A2
solute carrier family 2 (facilitated glucose transporter), member 2
chr6_+_100054649 3.662 NM_021620
PRDM13
PR domain containing 13
chr1_+_159557615 3.659 NM_001639
APCS
amyloid P component, serum
chr1_+_150480486 3.642 NM_001202858
NM_004425
NM_022664
ECM1


extracellular matrix protein 1


chr6_+_56954889 3.618 ZNF451
zinc finger protein 451
chr9_-_14086901 3.615 NFIB
nuclear factor I/B
chr1_+_212788359 3.596 NM_001206486
ATF3
activating transcription factor 3
chr5_+_70944968 3.562 MCCC2
methylcrotonoyl-CoA carboxylase 2 (beta)
chr18_+_33234532 3.531 NM_020474
GALNT1
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1)
chr20_-_34241830 3.523 NM_003915
CPNE1
copine I
chr5_+_42548144 3.510 NM_001242402
GHR
growth hormone receptor
chr1_+_174843523 3.468 NM_001243763
RABGAP1L
RAB GTPase activating protein 1-like
chr10_-_116392099 3.455 ABLIM1
actin binding LIM protein 1
chr11_-_5255712 3.439 NM_000519
HBD
hemoglobin, delta
chr7_+_80267922 3.439 CD36
CD36 molecule (thrombospondin receptor)
chrX_+_46940235 3.324 RGN
regucalcin (senescence marker protein-30)
chr10_+_89267589 3.288 NM_001178118
MINPP1
multiple inositol-polyphosphate phosphatase 1
chr1_+_63063186 3.265 NM_014495
ANGPTL3
angiopoietin-like 3
chr12_+_54892567 3.257 NM_001184976
NCKAP1L
NCK-associated protein 1-like
chr5_-_98262217 3.247 NM_001270
CHD1
chromodomain helicase DNA binding protein 1
chr10_+_124320180 3.241 NM_004406
NM_007329
NM_017579
DMBT1


deleted in malignant brain tumors 1


chr18_+_72922725 3.198 NM_005786
TSHZ1
teashirt zinc finger homeobox 1
chr9_-_138853007 3.194 UBAC1
UBA domain containing 1
chr2_+_172821874 3.181 HAT1
histone acetyltransferase 1
chr6_+_56954801 3.146 NM_001031623
NM_015555
ZNF451

zinc finger protein 451

chr8_-_108510094 3.124 NM_001146
NM_001199859
ANGPT1

angiopoietin 1

chrX_-_15288588 3.114 NM_001168531
ASB9
ankyrin repeat and SOCS box containing 9
chr3_+_100238063 3.074 TMEM45A
transmembrane protein 45A
chr6_+_34204928 3.021 HMGA1
high mobility group AT-hook 1
chr1_+_15764934 2.990 NM_007272
CTRC
chymotrypsin C (caldecrin)
chr1_-_104238785 2.961 NM_004038
NM_001008218
NM_001008219
AMY1A
AMY1B
AMY1C
amylase, alpha 1A (salivary)
amylase, alpha 1B (salivary)
amylase, alpha 1C (salivary)
chr13_-_46756291 2.961 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr4_-_151770611 2.958 LRBA
LPS-responsive vesicle trafficking, beach and anchor containing
chr5_+_68666861 2.957 NM_133340
NM_133341
RAD17

RAD17 homolog (S. pombe)

chr5_-_160279045 2.938 NM_025153
ATP10B
ATPase, class V, type 10B
chr14_+_21457964 2.933 NM_001029991
NM_022734
METTL17

methyltransferase like 17

chr12_+_32654976 2.925 NM_139241
FGD4
FYVE, RhoGEF and PH domain containing 4
chr6_+_30130982 2.885 NM_033229
TRIM15
tripartite motif containing 15
chr8_-_93111915 2.867 NM_001198628
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr2_-_79386878 2.809 NM_138938
NM_002580
NM_138937
REG3A


regenerating islet-derived 3 alpha


chr22_-_37098620 2.794 NM_006078
CACNG2
calcium channel, voltage-dependent, gamma subunit 2
chr1_+_212209129 2.767 DTL
denticleless homolog (Drosophila)
chr1_-_158656487 2.759 NM_003126
SPTA1
spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
chr12_-_4488707 2.728 NM_020638
FGF23
fibroblast growth factor 23
chr12_+_41831484 2.704 NM_013377
PDZRN4
PDZ domain containing ring finger 4
chr17_-_49124128 2.675 NM_001251971
SPAG9
sperm associated antigen 9
chr1_+_104198140 2.652 NM_001008221
AMY1A
amylase, alpha 1A (salivary)
chr6_-_64029847 2.639 NM_001143940
NM_016571
LGSN

lengsin, lens protein with glutamine synthetase domain

chr1_-_217262946 2.629 NM_001243506
NM_206594
NM_206595
ESRRG


estrogen-related receptor gamma


chr1_+_104292439 2.619 NM_004038
NM_001008218
NM_001008219
AMY1A
AMY1B
AMY1C
amylase, alpha 1A (salivary)
amylase, alpha 1B (salivary)
amylase, alpha 1C (salivary)
chr1_+_104292278 2.606 NM_001008221
AMY1A
amylase, alpha 1A (salivary)
chr16_-_15833937 2.590 MYH11
myosin, heavy chain 11, smooth muscle
chr11_+_22696318 2.580 NM_005256
GAS2
growth arrest-specific 2
chr12_-_102512277 2.567 NM_024057
NUP37
nucleoporin 37kDa
chr4_-_69536314 2.556 NM_001076
UGT2B15
UDP glucuronosyltransferase 2 family, polypeptide B15
chr21_-_43735705 2.544 NM_003226
TFF3
trefoil factor 3 (intestinal)
chr1_-_104239071 2.529 NM_001008221
AMY1A
amylase, alpha 1A (salivary)
chr1_+_24018293 2.528 RPL11
ribosomal protein L11
chr13_-_46679143 2.486 NM_001872
NM_016413
CPB2

carboxypeptidase B2 (plasma)

chr14_+_37126772 2.478 NM_006194
PAX9
paired box 9
chr6_+_45296053 2.478 NM_001015051
NM_001024630
RUNX2

runt-related transcription factor 2

chr3_-_105421044 2.464 CBLB
Cas-Br-M (murine) ecotropic retroviral transforming sequence b
chr1_+_104198301 2.462 NM_004038
NM_001008218
NM_001008219
AMY1A
AMY1B
AMY1C
amylase, alpha 1A (salivary)
amylase, alpha 1B (salivary)
amylase, alpha 1C (salivary)
chr11_+_57529233 2.423 NM_001085458
NM_001085459
NM_001085460
NM_001085461
NM_001085462
NM_001085463
NM_001085464
NM_001085465
NM_001085466
NM_001085467
NM_001085468
NM_001085469
NM_001206883
NM_001206884
NM_001206885
NM_001206886
NM_001206887
NM_001206888
NM_001206889
NM_001206890
NM_001206891
NM_001331
CTNND1





















catenin (cadherin-associated protein), delta 1





















chr16_+_81812925 2.406 PLCG2
phospholipase C, gamma 2 (phosphatidylinositol-specific)
chr13_-_103719195 2.397 NM_000452
SLC10A2
solute carrier family 10 (sodium/bile acid cotransporter family), member 2
chr17_-_3599298 2.390 P2RX5
purinergic receptor P2X, ligand-gated ion channel, 5
chr7_+_80267782 2.382 NM_000072
NM_001001548
CD36

CD36 molecule (thrombospondin receptor)

chr3_+_152017193 2.310 NM_207293
NM_207294
NM_207295
NM_207296
NM_207297
MBNL1




muscleblind-like (Drosophila)




chr10_-_124605690 2.304 NM_022034
CUZD1
CUB and zona pellucida-like domains 1
chr16_-_18798077 2.288


chr7_+_45933096 2.286


chr14_-_24020766 2.277 NM_033400
ZFHX2
zinc finger homeobox 2
chr9_-_123812535 2.268 NM_001735
C5
complement component 5
chr19_-_14992166 2.266 NM_030901
OR7A17
olfactory receptor, family 7, subfamily A, member 17
chr17_-_38721701 2.218 NM_001838
CCR7
chemokine (C-C motif) receptor 7
chr4_+_8951476 2.190 NM_001040071
LOC650293
seven transmembrane helix receptor
chr12_+_21525801 2.185 NM_000415
IAPP
islet amyloid polypeptide
chr17_-_3599359 2.167 P2RX5
purinergic receptor P2X, ligand-gated ion channel, 5
chr22_+_22723972 2.165


chr12_-_91398757 2.163 NM_004950
EPYC
epiphycan
chr10_-_65028825 2.144 NM_004241
JMJD1C
jumonji domain containing 1C
chr15_-_80263460 2.144 NM_001114735
NM_004049
BCL2A1

BCL2-related protein A1

chr4_-_70080448 2.128 NM_001073
UGT2B11
UGT2B10
UDP glucuronosyltransferase 2 family, polypeptide B11
UDP glucuronosyltransferase 2 family, polypeptide B10
chr4_-_84035888 2.101 PLAC8
placenta-specific 8
chr15_+_74900712 2.099 NM_003992
CLK3
CDC-like kinase 3
chr3_+_148545587 2.092 NM_001871
CPB1
carboxypeptidase B1 (tissue)
chr2_+_79252825 2.091 NM_001008387
NM_198448
REG3G

regenerating islet-derived 3 gamma

chr2_+_143886969 2.079 ARHGAP15
Rho GTPase activating protein 15
chr19_-_5846465 2.070 FUT3
fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)
chrX_+_100474932 2.064 NM_001171184
NM_001939
DRP2

dystrophin related protein 2

chrX_-_64196268 2.041 NM_001178033
NM_018684
ZC4H2

zinc finger, C4H2 domain containing

chr6_-_79675672 2.027 PHIP
pleckstrin homology domain interacting protein
chr1_+_45477916 2.026 UROD
uroporphyrinogen decarboxylase
chr3_-_57234279 2.020 NM_003865
HESX1
HESX homeobox 1
chr1_-_116383323 2.002 NM_001111061
NHLH2
nescient helix loop helix 2
chr4_-_69886112 1.995 NM_001075
NM_001144767
UGT2B10

UDP glucuronosyltransferase 2 family, polypeptide B10

chr4_-_72649734 1.995 NM_000583
GC
group-specific component (vitamin D binding protein)
chr6_-_32634287 1.994 NM_001243961
NM_002123
HLA-DQB1

major histocompatibility complex, class II, DQ beta 1

chr1_+_117297056 1.991 NM_001767
CD2
CD2 molecule
chr10_+_71561687 1.989 COL13A1
collagen, type XIII, alpha 1
chr12_-_9268440 1.986 A2M
alpha-2-macroglobulin
chr1_+_24018268 1.985 NM_000975
NM_001199802
RPL11

ribosomal protein L11

chr16_+_69680959 1.981 NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr14_+_58894709 1.956 NM_014749
KIAA0586
KIAA0586
chr4_+_69681709 1.934 NM_001075
NM_001144767
UGT2B10

UDP glucuronosyltransferase 2 family, polypeptide B10

chr3_+_186383770 1.928 NM_000412
HRG
histidine-rich glycoprotein
chr11_-_128712340 1.926 NM_000220
KCNJ1
potassium inwardly-rectifying channel, subfamily J, member 1
chrX_-_24690740 1.909 NM_001163264
PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr11_+_94800055 1.864 NM_032102
SRSF8
serine/arginine-rich splicing factor 8
chr8_+_17396285 1.857 NM_001164771
NM_003046
SLC7A2

solute carrier family 7 (cationic amino acid transporter, y+ system), member 2

chr17_-_3337134 1.853 NM_003554
OR1E2
olfactory receptor, family 1, subfamily E, member 2
chr6_+_27925018 1.850 NM_012367
OR2B6
olfactory receptor, family 2, subfamily B, member 6
chr2_-_217540722 1.829 IGFBP5
insulin-like growth factor binding protein 5
chr8_+_123794043 1.816 ZHX2
zinc fingers and homeoboxes 2
chr4_+_70916158 1.815 NM_002159
HTN1
histatin 1
chr7_+_80267972 1.813 CD36
CD36 molecule (thrombospondin receptor)
chr10_-_29754478 1.811 SVIL
supervillin
chr8_-_87755880 1.804 NM_019098
CNGB3
cyclic nucleotide gated channel beta 3
chr20_+_32150139 1.799 NM_001039709
NM_005093
CBFA2T2

core-binding factor, runt domain, alpha subunit 2; translocated to, 2

chr2_-_179672056 1.795 NM_003319
NM_133378
NM_133379
NM_133432
NM_133437
TTN




titin




chr15_-_64673569 1.795 NM_001029989
NM_014736
KIAA0101

KIAA0101

chr7_+_129008044 1.794 AHCYL2
adenosylhomocysteinase-like 2
chr7_-_25268057 1.763 NM_022150
NPVF
neuropeptide VF precursor

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.35 1.32e-05 GO:0032501 multicellular organismal process
1.30 2.86e-05 GO:0050896 response to stimulus
2.14 3.44e-05 GO:0006955 immune response
1.79 2.74e-04 GO:0002376 immune system process
1.21 1.27e-03 GO:0065007 biological regulation
1.37 1.69e-03 GO:0032502 developmental process
1.57 1.95e-03 GO:0048513 organ development
1.22 1.97e-03 GO:0050789 regulation of biological process
1.35 3.96e-03 GO:0023052 signaling
2.10 6.81e-03 GO:0007186 G-protein coupled receptor protein signaling pathway
1.31 1.21e-02 GO:0051716 cellular response to stimulus
1.35 1.47e-02 GO:0007275 multicellular organismal development
1.35 1.83e-02 GO:0007165 signal transduction
2.12 3.13e-02 GO:0050776 regulation of immune response
1.50 3.24e-02 GO:0007166 cell surface receptor linked signaling pathway
1.35 4.89e-02 GO:0048856 anatomical structure development

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.59 1.46e-05 GO:0005576 extracellular region
1.83 8.44e-05 GO:0044421 extracellular region part
1.48 8.94e-04 GO:0044459 plasma membrane part
1.66 1.37e-03 GO:0005887 integral to plasma membrane
1.65 1.50e-03 GO:0031226 intrinsic to plasma membrane
1.83 2.42e-03 GO:0005615 extracellular space
1.27 1.32e-02 GO:0071944 cell periphery
1.27 1.59e-02 GO:0005886 plasma membrane
8.68 4.77e-02 GO:0042613 MHC class II protein complex
12.15 4.88e-02 GO:0042589 zymogen granule membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
4.97 2.74e-02 GO:0043498 cell surface binding