Motif ID: PAX5.p2

Z-value: 1.884


Transcription factors associated with PAX5.p2:

Gene SymbolEntrez IDGene Name
PAX5 5079 paired box 5

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
PAX5chr9_-_37034358-0.714.1e-35Click!


Activity profile for motif PAX5.p2.

activity profile for motif PAX5.p2


Sorted Z-values histogram for motif PAX5.p2

Sorted Z-values for motif PAX5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PAX5.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_-_2950593 35.367 NM_003311
PHLDA2
pleckstrin homology-like domain, family A, member 2
chr6_-_4135701 32.301 NM_001166010
NM_006117
NM_206836
ECI2


enoyl-CoA delta isomerase 2


chr2_+_235860616 31.114 NM_014521
SH3BP4
SH3-domain binding protein 4
chr16_+_1359653 30.440 UBE2I
ubiquitin-conjugating enzyme E2I
chrX_+_133594171 30.367 NM_000194
HPRT1
hypoxanthine phosphoribosyltransferase 1
chr16_+_1359636 30.227 UBE2I
ubiquitin-conjugating enzyme E2I
chr16_+_1359692 29.497 UBE2I
ubiquitin-conjugating enzyme E2I
chr20_+_388941 28.866 RBCK1
RanBP-type and C3HC4-type zinc finger containing 1
chrX_+_133594225 28.771 HPRT1
hypoxanthine phosphoribosyltransferase 1
chr16_+_1359673 28.224 UBE2I
ubiquitin-conjugating enzyme E2I
chr2_-_215674292 25.640 NM_000465
BARD1
BRCA1 associated RING domain 1
chr3_-_185542807 24.497 NM_001007225
NM_006548
IGF2BP2

insulin-like growth factor 2 mRNA binding protein 2

chr2_-_179315756 24.307 NM_003690
PRKRA
protein kinase, interferon-inducible double stranded RNA dependent activator
chr19_-_291168 24.239 NM_177543
PPAP2C
phosphatidic acid phosphatase type 2C
chr4_+_57302268 24.143 NM_001079524
NM_001079525
PAICS

phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase

chr7_+_26241281 23.174 NM_016587
CBX3
chromobox homolog 3
chrX_+_118602391 22.937 SLC25A5
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
chr20_+_62371218 22.762 SLC2A4RG
SLC2A4 regulator
chr7_-_105752650 22.615 SYPL1
synaptophysin-like 1
chr20_+_62371109 22.556 NM_020062
SLC2A4RG
SLC2A4 regulator
chrX_+_133594297 22.284 HPRT1
hypoxanthine phosphoribosyltransferase 1
chrX_+_118602362 22.147 NM_001152
SLC25A5
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
chr5_+_122110778 22.030 SNX2
sorting nexin 2
chr18_+_29671925 21.423 RNF138
ring finger protein 138
chr4_+_57301898 21.023 NM_006452
PAICS
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
chr7_-_105925329 20.994 NAMPT
nicotinamide phosphoribosyltransferase
chr12_-_109125254 20.978 CORO1C
coronin, actin binding protein, 1C
chr18_+_11981421 20.888 NM_014214
IMPA2
inositol(myo)-1(or 4)-monophosphatase 2
chr1_+_87170515 20.554 SH3GLB1
SH3-domain GRB2-like endophilin B1
chr21_+_45139169 20.548 PDXK
pyridoxal (pyridoxine, vitamin B6) kinase
chr9_+_131451823 20.508 SET
SET nuclear oncogene
chr18_+_657674 19.894 TYMS
thymidylate synthetase
chr14_+_56046796 19.871 NM_001079521
NM_001079522
NM_004986
NM_182926
KTN1



kinectin 1 (kinesin receptor)



chr2_-_174829108 19.651 SP3
Sp3 transcription factor
chr13_+_28196029 19.500 POLR1D
polymerase (RNA) I polypeptide D, 16kDa
chr20_+_57556322 19.237 TH1L
TH1-like (Drosophila)
chr3_+_128997713 19.157 NM_001006109
C3orf37
chromosome 3 open reading frame 37
chr13_+_28196024 18.936 POLR1D
polymerase (RNA) I polypeptide D, 16kDa
chrX_-_152989822 18.901 NM_005745
BCAP31
B-cell receptor-associated protein 31
chr18_+_29671817 18.160 NM_016271
RNF138
ring finger protein 138
chr15_+_57210852 18.128 TCF12
transcription factor 12
chr2_-_32236104 18.124 MEMO1
mediator of cell motility 1
chr6_-_18264638 17.998 NM_001134709
NM_003472
DEK

DEK oncogene

chr2_+_85198176 17.931 NM_020122
KCMF1
potassium channel modulatory factor 1
chr18_+_12308236 17.882 TUBB6
tubulin, beta 6 class V
chr2_+_238600780 17.751 NM_001137551
NM_001137552
NM_001137553
NM_004735
LRRFIP1



leucine rich repeat (in FLII) interacting protein 1



chr7_+_26241372 17.688 CBX3
chromobox homolog 3
chr2_+_238600878 17.636 LRRFIP1
leucine rich repeat (in FLII) interacting protein 1
chr12_-_109125289 17.608 NM_014325
CORO1C
coronin, actin binding protein, 1C
chr21_-_46293609 17.433 NM_004339
PTTG1IP
pituitary tumor-transforming 1 interacting protein
chr3_-_53289957 17.411 TKT
transketolase
chr11_-_64014264 17.318 PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr5_+_68462948 17.317 CCNB1
cyclin B1
chr5_+_68462836 17.288 NM_031966
CCNB1
cyclin B1
chr17_-_62658311 17.265 NM_022739
SMURF2
SMAD specific E3 ubiquitin protein ligase 2
chr9_+_131451847 17.169 SET
SET nuclear oncogene
chr5_+_68462985 16.986 CCNB1
cyclin B1
chr5_+_122110737 16.880 NM_003100
SNX2
sorting nexin 2
chr15_+_57210972 16.855 TCF12
transcription factor 12
chr12_+_3068442 16.819 NM_003213
NM_201441
NM_201443
TEAD4


TEA domain family member 4


chr20_+_388717 16.536 RBCK1
RanBP-type and C3HC4-type zinc finger containing 1
chr10_+_28822387 16.386 NM_016628
NM_100486
WAC

WW domain containing adaptor with coiled-coil

chr18_+_29078026 16.273 NM_001943
DSG2
desmoglein 2
chr18_+_34409058 16.240 NM_020776
KIAA1328
KIAA1328
chr12_-_109125275 16.237 CORO1C
coronin, actin binding protein, 1C
chr1_+_87170486 16.181 SH3GLB1
SH3-domain GRB2-like endophilin B1
chr2_+_10262853 16.145 NM_001034
RRM2
ribonucleotide reductase M2
chr2_+_10262694 15.982 NM_001165931
RRM2
ribonucleotide reductase M2
chr21_-_46293561 15.942 PTTG1IP
pituitary tumor-transforming 1 interacting protein
chr19_-_1567875 15.913 NM_001174118
NM_203304
MEX3D

mex-3 homolog D (C. elegans)

chr19_-_291335 15.818 NM_003712
NM_177526
PPAP2C

phosphatidic acid phosphatase type 2C

chr3_-_53290099 15.807 NM_001064
NM_001135055
TKT

transketolase

chr5_+_95998170 15.754 CAST
calpastatin
chr7_+_26241329 15.704 CBX3
chromobox homolog 3
chr13_+_28196004 15.476 POLR1D
polymerase (RNA) I polypeptide D, 16kDa
chr11_-_34937831 15.446 NM_015957
APIP
APAF1 interacting protein
chr18_+_12308242 15.419 NM_032525
TUBB6
tubulin, beta 6 class V
chr10_+_120863626 15.380 FAM45A
FAM45B
family with sequence similarity 45, member A
family with sequence similarity 45, member A pseudogene
chr12_-_13153047 15.296 HEBP1
heme binding protein 1
chr4_+_1723233 15.257 TACC3
transforming, acidic coiled-coil containing protein 3
chr18_+_11981552 15.257 IMPA2
inositol(myo)-1(or 4)-monophosphatase 2
chr7_+_26241044 15.231 CBX3
chromobox homolog 3
chr8_+_145149936 15.089 NM_001916
CYC1
cytochrome c-1
chr17_-_80606095 15.081 NM_019613
WDR45L
WDR45-like
chr4_+_1723212 15.043 NM_006342
TACC3
transforming, acidic coiled-coil containing protein 3
chr17_-_62658175 15.010 SMURF2
SMAD specific E3 ubiquitin protein ligase 2
chr2_+_181845368 14.896 UBE2E3
ubiquitin-conjugating enzyme E2E 3
chr17_-_62657997 14.848 SMURF2
SMAD specific E3 ubiquitin protein ligase 2
chrX_-_152989851 14.842 BCAP31
B-cell receptor-associated protein 31
chr9_+_110046333 14.840 NM_001244724
RAD23B
RAD23 homolog B (S. cerevisiae)
chr2_-_179315354 14.836 NM_001139518
NM_001139517
PRKRA

protein kinase, interferon-inducible double stranded RNA dependent activator

chr3_+_23847349 14.834 NM_003341
NM_182666
UBE2E1

ubiquitin-conjugating enzyme E2E 1

chr7_-_105752718 14.713 NM_182715
SYPL1
synaptophysin-like 1
chr18_-_812268 14.620 NM_005433
YES1
v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1
chr17_+_35849997 14.549 DUSP14
dual specificity phosphatase 14
chr1_+_955468 14.434 NM_198576
AGRN
agrin
chr8_+_145149978 14.410 CYC1
cytochrome c-1
chr21_-_46293532 14.325 PTTG1IP
pituitary tumor-transforming 1 interacting protein
chr1_+_87170286 14.279 SH3GLB1
SH3-domain GRB2-like endophilin B1
chr21_-_46293598 14.239 PTTG1IP
pituitary tumor-transforming 1 interacting protein
chr19_+_35645640 14.226 NM_144779
NM_001164605
FXYD5

FXYD domain containing ion transport regulator 5

chr10_+_120863610 14.139 NM_207009
FAM45A
family with sequence similarity 45, member A
chr18_+_12947972 14.139 NM_001013437
NM_031216
SEH1L

SEH1-like (S. cerevisiae)

chr13_+_28195913 14.063 NM_015972
NM_152705
POLR1D

polymerase (RNA) I polypeptide D, 16kDa

chr15_-_34331185 14.054 NM_020371
AVEN
apoptosis, caspase activation inhibitor
chr18_-_34408845 14.044 TPGS2
tubulin polyglutamylase complex subunit 2
chr7_-_105752974 14.042 NM_006754
SYPL1
synaptophysin-like 1
chr19_-_55918980 14.033 UBE2S
ubiquitin-conjugating enzyme E2S
chr12_-_13153200 13.914 NM_015987
HEBP1
heme binding protein 1
chr2_+_85198431 13.910 KCMF1
potassium channel modulatory factor 1
chr15_+_57210823 13.810 NM_003205
NM_207036
NM_207037
NM_207038
TCF12



transcription factor 12



chr10_+_88854900 13.810 NM_019054
FAM35A
family with sequence similarity 35, member A
chr20_+_57556295 13.714 NM_198976
TH1L
TH1-like (Drosophila)
chr15_-_60690115 13.679 NM_001002857
NM_001002858
NM_001136015
NM_004039
ANXA2



annexin A2



chr9_+_114423888 13.548 GNG10
guanine nucleotide binding protein (G protein), gamma 10
chr3_+_128997616 13.543 NM_020187
C3orf37
chromosome 3 open reading frame 37
chr10_+_124914279 13.313 BUB3
budding uninhibited by benzimidazoles 3 homolog (yeast)
chr12_-_76425207 13.302 PHLDA1
pleckstrin homology-like domain, family A, member 1
chr12_+_69004710 13.188 RAP1B
RAP1B, member of RAS oncogene family
chr15_-_59949536 13.058 NM_004492
GTF2A2
general transcription factor IIA, 2, 12kDa
chr1_+_43824598 12.950 NM_001255
CDC20
cell division cycle 20 homolog (S. cerevisiae)
chr3_-_182698291 12.915 NM_020640
DCUN1D1
DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)
chr2_+_109150807 12.897 NM_001193483
LIMS1
LIM and senescent cell antigen-like domains 1
chr1_-_1822501 12.826 GNB1
guanine nucleotide binding protein (G protein), beta polypeptide 1
chr12_+_131356640 12.755 RAN
RAN, member RAS oncogene family
chr10_+_82213892 12.715 NM_001128309
NM_030927
TSPAN14

tetraspanin 14

chr3_-_69129502 12.672 NM_003968
NM_198195
UBA3

ubiquitin-like modifier activating enzyme 3

chr21_+_42540054 12.655 BACE2
beta-site APP-cleaving enzyme 2
chr2_-_9770366 12.573 YWHAQ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
chr21_+_42540092 12.568 BACE2
beta-site APP-cleaving enzyme 2
chr17_-_15466772 12.554 NM_001204478
NM_001135036
NM_145301
FAM18B2-CDRT4
FAM18B2

FAM18B2-CDRT4 readthrough
family with sequence similarity 18, member B2

chr3_+_100428393 12.523 TFG
TRK-fused gene
chr8_+_97274106 12.489 PTDSS1
phosphatidylserine synthase 1
chr7_+_116139619 12.465 NM_001206747
NM_001233
NM_198212
CAV2


caveolin 2


chr3_-_185542744 12.419 IGF2BP2
insulin-like growth factor 2 mRNA binding protein 2
chr2_+_181845803 12.402 UBE2E3
ubiquitin-conjugating enzyme E2E 3
chr15_-_59225766 12.391 SLTM
SAFB-like, transcription modulator
chr5_+_95997871 12.373 NM_001042440
CAST
calpastatin
chr20_+_55926299 12.296 RAE1
RAE1 RNA export 1 homolog (S. pombe)
chr11_+_101980736 12.290 NM_001130145
NM_001195044
NM_006106
YAP1


Yes-associated protein 1


chr7_+_87505543 12.267 NM_006716
DBF4
DBF4 homolog (S. cerevisiae)
chr2_+_181845605 12.267 UBE2E3
ubiquitin-conjugating enzyme E2E 3
chrX_-_152989807 12.209


chr15_+_80352043 12.179 ZFAND6
zinc finger, AN1-type domain 6
chr9_+_131452253 12.177 NM_001248001
SET
SET nuclear oncogene
chr5_+_10353980 12.158


chr6_+_158589378 11.941 NM_207118
GTF2H5
general transcription factor IIH, polypeptide 5
chr3_+_100053544 11.909 NM_020202
NIT2
nitrilase family, member 2
chr1_-_152009406 11.908 S100A11
S100 calcium binding protein A11
chr11_+_1968499 11.879 NM_021134
MRPL23
mitochondrial ribosomal protein L23
chr2_-_234763145 11.854 HJURP
Holliday junction recognition protein
chr21_-_45196200 11.725 NM_000100
CSTB
cystatin B (stefin B)
chr20_+_32581553 11.631 RALY
RNA binding protein, autoantigenic (hnRNP-associated with lethal yellow homolog (mouse))
chr14_+_97263681 11.597 NM_003384
VRK1
vaccinia related kinase 1
chr1_+_162531229 11.563 NM_003115
UAP1
UDP-N-acteylglucosamine pyrophosphorylase 1
chr3_-_52567809 11.520 NT5DC2
5'-nucleotidase domain containing 2
chr20_+_60878024 11.507 NM_007002
NM_175573
ADRM1

adhesion regulating molecule 1

chr10_+_88516340 11.505 NM_004329
BMPR1A
bone morphogenetic protein receptor, type IA
chr13_+_98628712 11.486 IPO5
importin 5
chr18_-_34408948 11.422 TPGS2
tubulin polyglutamylase complex subunit 2
chr16_-_87903028 11.418 NM_003486
SLC7A5
solute carrier family 7 (amino acid transporter light chain, L system), member 5
chr9_+_131451470 11.414 NM_003011
SET
SET nuclear oncogene
chr11_-_64014407 11.357 NM_138689
PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr2_-_234763182 11.220 NM_018410
HJURP
Holliday junction recognition protein
chr18_-_9614555 11.198 NM_001042388
NM_005134
PPP4R1

protein phosphatase 4, regulatory subunit 1

chr20_+_61427804 11.097 NM_018270
C20orf20
chromosome 20 open reading frame 20
chr18_+_29672568 11.096 NM_001191324
NM_198128
RNF138

ring finger protein 138

chr1_+_955609 11.093 AGRN
agrin
chr18_-_9614454 10.915 PPP4R1
protein phosphatase 4, regulatory subunit 1
chr15_+_80352018 10.902 ZFAND6
zinc finger, AN1-type domain 6
chr16_+_81040120 10.875 CENPN
centromere protein N
chr17_+_37026309 10.866 LASP1
LIM and SH3 protein 1
chr1_-_8938745 10.862 ENO1
enolase 1, (alpha)
chr2_+_181845088 10.848 NM_182678
NM_006357
UBE2E3

ubiquitin-conjugating enzyme E2E 3

chr12_+_121837843 10.835 NM_025126
NM_194271
RNF34

ring finger protein 34

chr1_-_152009440 10.831 S100A11
S100 calcium binding protein A11
chr21_-_46238040 10.799 NM_006936
SUMO3
SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae)
chr22_+_43547558 10.786 TSPO
translocator protein (18kDa)
chr16_+_88923490 10.771 NM_016209
TRAPPC2L
trafficking protein particle complex 2-like
chr1_-_8939150 10.736 NM_001428
ENO1
enolase 1, (alpha)
chr2_-_9770999 10.679 YWHAQ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
chr3_+_171758289 10.679 NM_001135095
FNDC3B
fibronectin type III domain containing 3B
chr7_-_105925410 10.651 NM_005746
NAMPT
nicotinamide phosphoribosyltransferase
chr14_+_73603140 10.552 NM_000021
NM_007318
PSEN1

presenilin 1

chr16_-_50402685 10.529 NM_001173984
NM_013263
BRD7

bromodomain containing 7

chr20_-_33872571 10.513 NM_002212
NM_181466
EIF6

eukaryotic translation initiation factor 6

chr7_+_26240830 10.382 NM_007276
CBX3
chromobox homolog 3
chr10_+_81107219 10.373 NM_005729
PPIF
peptidylprolyl isomerase F
chr15_+_57210889 10.367 TCF12
transcription factor 12
chr15_+_80352257 10.350 NM_001242913
ZFAND6
zinc finger, AN1-type domain 6
chr11_+_34938112 10.335 PDHX
pyruvate dehydrogenase complex, component X
chr1_-_8938727 10.334 ENO1
enolase 1, (alpha)
chr14_+_100705101 10.324 NM_003403
YY1
YY1 transcription factor
chr14_-_102553344 10.322 HSP90AA1
heat shock protein 90kDa alpha (cytosolic), class A member 1
chr11_+_65686727 10.321 NM_006442
DRAP1
DR1-associated protein 1 (negative cofactor 2 alpha)
chr15_-_90777144 10.288 CIB1
calcium and integrin binding 1 (calmyrin)
chr16_-_81129882 10.233 NM_004483
GCSH
glycine cleavage system protein H (aminomethyl carrier)
chr17_+_35849950 10.232 NM_007026
DUSP14
dual specificity phosphatase 14
chr20_-_33872505 10.221 NM_181468
EIF6
eukaryotic translation initiation factor 6
chr10_+_95256348 10.215 NM_001127182
NM_018131
CEP55

centrosomal protein 55kDa


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.17 5.29e-58 GO:0009987 cellular process
1.31 6.56e-52 GO:0044237 cellular metabolic process
1.26 3.92e-46 GO:0008152 metabolic process
1.28 3.58e-42 GO:0044238 primary metabolic process
1.33 8.04e-34 GO:0044260 cellular macromolecule metabolic process
1.28 4.66e-30 GO:0043170 macromolecule metabolic process
1.19 5.12e-29 GO:0065007 biological regulation
1.20 1.08e-27 GO:0050789 regulation of biological process
1.35 1.41e-26 GO:0006807 nitrogen compound metabolic process
1.35 2.95e-25 GO:0034641 cellular nitrogen compound metabolic process
1.40 8.49e-24 GO:0048522 positive regulation of cellular process
1.20 9.80e-24 GO:0050794 regulation of cellular process
1.37 1.33e-23 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.37 2.04e-23 GO:0048518 positive regulation of biological process
1.32 1.90e-22 GO:0016043 cellular component organization
1.31 5.60e-22 GO:0071840 cellular component organization or biogenesis
1.36 9.60e-18 GO:0042221 response to chemical stimulus
1.32 3.47e-16 GO:0071842 cellular component organization at cellular level
1.31 3.54e-16 GO:0071841 cellular component organization or biogenesis at cellular level
1.35 4.67e-16 GO:0090304 nucleic acid metabolic process
1.48 6.56e-16 GO:0010033 response to organic substance
1.32 3.44e-15 GO:0044267 cellular protein metabolic process
1.49 7.28e-15 GO:0044248 cellular catabolic process
1.23 1.89e-14 GO:0051716 cellular response to stimulus
1.43 2.63e-14 GO:0009056 catabolic process
1.31 1.03e-13 GO:0044249 cellular biosynthetic process
1.27 5.13e-13 GO:0019538 protein metabolic process
1.32 1.24e-12 GO:0048523 negative regulation of cellular process
1.43 1.43e-12 GO:0051641 cellular localization
1.29 1.76e-12 GO:0009058 biosynthetic process
1.56 2.01e-12 GO:0046907 intracellular transport
1.22 4.63e-12 GO:0019222 regulation of metabolic process
1.45 5.09e-12 GO:0010604 positive regulation of macromolecule metabolic process
1.47 1.50e-11 GO:0007049 cell cycle
1.29 1.54e-11 GO:0048519 negative regulation of biological process
1.42 1.87e-11 GO:0009893 positive regulation of metabolic process
1.46 6.14e-11 GO:0042981 regulation of apoptosis
1.45 7.24e-11 GO:0043067 regulation of programmed cell death
1.44 7.73e-11 GO:0051649 establishment of localization in cell
1.34 1.19e-10 GO:0016070 RNA metabolic process
1.44 1.49e-10 GO:0010941 regulation of cell death
1.41 1.77e-10 GO:0031325 positive regulation of cellular metabolic process
1.43 2.55e-10 GO:0051246 regulation of protein metabolic process
1.23 2.63e-10 GO:0060255 regulation of macromolecule metabolic process
1.46 2.99e-10 GO:0042127 regulation of cell proliferation
1.22 5.83e-10 GO:0051179 localization
1.55 6.67e-10 GO:0009719 response to endogenous stimulus
1.27 7.96e-10 GO:0006950 response to stress
1.23 8.03e-10 GO:0048856 anatomical structure development
1.20 8.19e-10 GO:0032502 developmental process
1.21 9.63e-10 GO:0023052 signaling
1.22 1.11e-09 GO:0007165 signal transduction
1.34 1.13e-09 GO:0006996 organelle organization
1.21 1.95e-09 GO:0031323 regulation of cellular metabolic process
1.21 2.46e-09 GO:0080090 regulation of primary metabolic process
1.39 2.74e-09 GO:0044085 cellular component biogenesis
1.31 2.85e-09 GO:0006464 protein modification process
1.43 2.96e-09 GO:0032268 regulation of cellular protein metabolic process
1.28 3.54e-09 GO:0065008 regulation of biological quality
1.42 4.47e-09 GO:0022607 cellular component assembly
1.33 4.62e-09 GO:0023051 regulation of signaling
1.35 4.74e-09 GO:0009966 regulation of signal transduction
1.32 6.64e-09 GO:0009059 macromolecule biosynthetic process
1.32 7.00e-09 GO:0034645 cellular macromolecule biosynthetic process
1.50 8.75e-09 GO:0012501 programmed cell death
1.54 1.69e-08 GO:0009725 response to hormone stimulus
1.53 1.87e-08 GO:0051726 regulation of cell cycle
1.29 2.07e-08 GO:0043412 macromolecule modification
1.29 2.55e-08 GO:0010467 gene expression
1.46 3.15e-08 GO:0022402 cell cycle process
1.55 3.18e-08 GO:0000278 mitotic cell cycle
1.45 3.22e-08 GO:0033554 cellular response to stress
1.44 3.53e-08 GO:0008219 cell death
1.44 3.82e-08 GO:0016265 death
1.35 5.55e-08 GO:0033036 macromolecule localization
1.49 5.59e-08 GO:0006915 apoptosis
1.13 6.17e-08 GO:0050896 response to stimulus
1.51 6.21e-08 GO:0007167 enzyme linked receptor protein signaling pathway
1.33 6.31e-08 GO:0065009 regulation of molecular function
1.59 9.30e-08 GO:0070271 protein complex biogenesis
1.22 1.04e-07 GO:0048731 system development
1.49 1.10e-07 GO:0022403 cell cycle phase
1.32 1.37e-07 GO:0009653 anatomical structure morphogenesis
1.29 1.52e-07 GO:0044281 small molecule metabolic process
1.58 1.98e-07 GO:0006461 protein complex assembly
1.74 2.65e-07 GO:0006366 transcription from RNA polymerase II promoter
1.21 3.78e-07 GO:0051234 establishment of localization
1.27 3.90e-07 GO:0048583 regulation of response to stimulus
1.44 3.98e-07 GO:0031399 regulation of protein modification process
1.21 4.71e-07 GO:0006810 transport
1.47 5.55e-07 GO:0065003 macromolecular complex assembly
1.35 9.54e-07 GO:0050790 regulation of catalytic activity
1.42 1.04e-06 GO:0043933 macromolecular complex subunit organization
1.36 1.28e-06 GO:0010646 regulation of cell communication
1.47 1.28e-06 GO:0046483 heterocycle metabolic process
1.30 1.33e-06 GO:0007399 nervous system development
1.49 1.36e-06 GO:0009057 macromolecule catabolic process
1.53 2.09e-06 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.51 2.20e-06 GO:0055086 nucleobase, nucleoside and nucleotide metabolic process
1.66 2.23e-06 GO:0043434 response to peptide hormone stimulus
1.63 2.41e-06 GO:0044419 interspecies interaction between organisms
1.18 2.43e-06 GO:0007275 multicellular organismal development
1.49 2.94e-06 GO:0071822 protein complex subunit organization
1.68 4.47e-06 GO:0051325 interphase
1.52 4.52e-06 GO:0006753 nucleoside phosphate metabolic process
1.52 4.52e-06 GO:0009117 nucleotide metabolic process
1.49 4.95e-06 GO:0050878 regulation of body fluid levels
1.68 6.28e-06 GO:0051329 interphase of mitotic cell cycle
1.40 1.02e-05 GO:0051128 regulation of cellular component organization
1.34 1.11e-05 GO:0008104 protein localization
1.55 1.18e-05 GO:0072521 purine-containing compound metabolic process
1.57 1.18e-05 GO:0051247 positive regulation of protein metabolic process
1.38 1.37e-05 GO:0045184 establishment of protein localization
1.43 1.51e-05 GO:0019220 regulation of phosphate metabolic process
1.43 1.51e-05 GO:0051174 regulation of phosphorus metabolic process
1.38 1.55e-05 GO:0009891 positive regulation of biosynthetic process
1.49 2.02e-05 GO:0044265 cellular macromolecule catabolic process
1.41 2.05e-05 GO:0016192 vesicle-mediated transport
1.38 2.31e-05 GO:0015031 protein transport
1.36 3.11e-05 GO:0022008 neurogenesis
1.50 3.55e-05 GO:0007599 hemostasis
1.61 3.60e-05 GO:0071495 cellular response to endogenous stimulus
1.47 4.74e-05 GO:0016071 mRNA metabolic process
1.37 4.81e-05 GO:0031328 positive regulation of cellular biosynthetic process
1.63 5.44e-05 GO:0032870 cellular response to hormone stimulus
1.43 5.59e-05 GO:0030030 cell projection organization
1.41 6.83e-05 GO:0042325 regulation of phosphorylation
1.49 6.94e-05 GO:0007596 blood coagulation
1.49 6.94e-05 GO:0050817 coagulation
1.22 7.78e-05 GO:0048869 cellular developmental process
1.55 8.16e-05 GO:0032270 positive regulation of cellular protein metabolic process
1.72 8.25e-05 GO:0032868 response to insulin stimulus
1.34 8.31e-05 GO:0009892 negative regulation of metabolic process
1.36 9.39e-05 GO:0006351 transcription, DNA-dependent
1.91 9.74e-05 GO:0000082 G1/S transition of mitotic cell cycle
1.44 1.12e-04 GO:0042060 wound healing
1.47 1.22e-04 GO:0010942 positive regulation of cell death
1.80 1.29e-04 GO:0032869 cellular response to insulin stimulus
1.58 1.47e-04 GO:0009259 ribonucleotide metabolic process
1.42 1.49e-04 GO:0001932 regulation of protein phosphorylation
1.64 1.68e-04 GO:0007346 regulation of mitotic cell cycle
1.46 1.80e-04 GO:0043068 positive regulation of programmed cell death
1.46 1.83e-04 GO:0008284 positive regulation of cell proliferation
1.46 1.94e-04 GO:0043065 positive regulation of apoptosis
1.71 1.94e-04 GO:0071375 cellular response to peptide hormone stimulus
1.65 1.97e-04 GO:0009166 nucleotide catabolic process
1.43 2.22e-04 GO:0006259 DNA metabolic process
1.27 2.24e-04 GO:0035556 intracellular signal transduction
1.59 2.33e-04 GO:0009150 purine ribonucleotide metabolic process
1.22 2.49e-04 GO:0030154 cell differentiation
1.37 2.87e-04 GO:0051173 positive regulation of nitrogen compound metabolic process
1.35 3.00e-04 GO:0048699 generation of neurons
1.37 3.09e-04 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.45 3.19e-04 GO:0070727 cellular macromolecule localization
1.52 3.32e-04 GO:0006163 purine nucleotide metabolic process
1.45 3.44e-04 GO:0034613 cellular protein localization
1.89 3.57e-04 GO:0008286 insulin receptor signaling pathway
1.35 3.94e-04 GO:0044093 positive regulation of molecular function
1.46 4.23e-04 GO:0043549 regulation of kinase activity
1.40 4.36e-04 GO:0071310 cellular response to organic substance
1.37 4.43e-04 GO:0071844 cellular component assembly at cellular level
1.32 4.53e-04 GO:0032774 RNA biosynthetic process
1.54 4.56e-04 GO:0051301 cell division
1.58 4.85e-04 GO:0009141 nucleoside triphosphate metabolic process
1.40 6.40e-04 GO:0032989 cellular component morphogenesis
1.33 6.59e-04 GO:0048468 cell development
1.36 6.69e-04 GO:0010557 positive regulation of macromolecule biosynthetic process
1.33 6.83e-04 GO:0010605 negative regulation of macromolecule metabolic process
1.45 6.90e-04 GO:0048858 cell projection morphogenesis
1.44 7.49e-04 GO:0032990 cell part morphogenesis
1.31 7.88e-04 GO:0009605 response to external stimulus
1.46 7.90e-04 GO:0009628 response to abiotic stimulus
1.44 8.13e-04 GO:0006974 response to DNA damage stimulus
1.43 8.14e-04 GO:0044282 small molecule catabolic process
1.38 8.70e-04 GO:0045595 regulation of cell differentiation
1.44 1.01e-03 GO:0031175 neuron projection development
1.50 1.05e-03 GO:0006886 intracellular protein transport
1.30 1.12e-03 GO:0006793 phosphorus metabolic process
1.30 1.12e-03 GO:0006796 phosphate metabolic process
1.57 1.17e-03 GO:0009199 ribonucleoside triphosphate metabolic process
1.47 1.19e-03 GO:0043066 negative regulation of apoptosis
1.47 1.30e-03 GO:0043069 negative regulation of programmed cell death
1.52 1.45e-03 GO:0010564 regulation of cell cycle process
1.63 1.53e-03 GO:0006195 purine nucleotide catabolic process
1.37 1.54e-03 GO:0051254 positive regulation of RNA metabolic process
1.32 1.57e-03 GO:0050793 regulation of developmental process
1.40 1.59e-03 GO:0000902 cell morphogenesis
1.46 1.69e-03 GO:0060548 negative regulation of cell death
1.43 1.74e-03 GO:0051338 regulation of transferase activity
1.56 1.75e-03 GO:0009144 purine nucleoside triphosphate metabolic process
1.56 1.87e-03 GO:0009205 purine ribonucleoside triphosphate metabolic process
1.44 2.02e-03 GO:0045859 regulation of protein kinase activity
1.55 2.12e-03 GO:0044270 cellular nitrogen compound catabolic process
1.26 2.28e-03 GO:0051239 regulation of multicellular organismal process
1.43 2.36e-03 GO:0009967 positive regulation of signal transduction
1.57 2.43e-03 GO:0034655 nucleobase, nucleoside, nucleotide and nucleic acid catabolic process
1.57 2.43e-03 GO:0034656 nucleobase, nucleoside and nucleotide catabolic process
1.56 2.61e-03 GO:0051270 regulation of cellular component movement
1.46 2.63e-03 GO:0008285 negative regulation of cell proliferation
1.61 2.81e-03 GO:0072523 purine-containing compound catabolic process
1.45 2.92e-03 GO:0048812 neuron projection morphogenesis
1.17 3.09e-03 GO:0009889 regulation of biosynthetic process
1.45 3.17e-03 GO:0016044 cellular membrane organization
1.30 3.22e-03 GO:0070887 cellular response to chemical stimulus
1.63 3.38e-03 GO:0048011 nerve growth factor receptor signaling pathway
1.44 3.45e-03 GO:0048646 anatomical structure formation involved in morphogenesis
1.29 3.85e-03 GO:0032879 regulation of localization
1.46 3.87e-03 GO:0016032 viral reproduction
1.46 3.87e-03 GO:0016477 cell migration
1.44 4.33e-03 GO:0061024 membrane organization
1.49 4.39e-03 GO:0016568 chromatin modification
1.30 4.39e-03 GO:0031324 negative regulation of cellular metabolic process
1.55 4.71e-03 GO:0042493 response to drug
1.44 5.02e-03 GO:0048667 cell morphogenesis involved in neuron differentiation
1.74 5.02e-03 GO:0071496 cellular response to external stimulus
1.56 5.07e-03 GO:0010035 response to inorganic substance
1.62 5.61e-03 GO:0051259 protein oligomerization
1.39 5.68e-03 GO:0006928 cellular component movement
1.45 5.80e-03 GO:0043086 negative regulation of catalytic activity
1.51 5.93e-03 GO:0007411 axon guidance
1.91 6.38e-03 GO:0010720 positive regulation of cell development
1.36 6.64e-03 GO:0006396 RNA processing
1.49 6.99e-03 GO:0006917 induction of apoptosis
1.31 7.85e-03 GO:0048584 positive regulation of response to stimulus
1.30 8.04e-03 GO:0009611 response to wounding
1.38 8.21e-03 GO:0048666 neuron development
1.48 8.30e-03 GO:0012502 induction of programmed cell death
1.16 8.62e-03 GO:0031326 regulation of cellular biosynthetic process
1.56 8.62e-03 GO:2000145 regulation of cell motility
1.39 9.13e-03 GO:0044092 negative regulation of molecular function
1.41 9.14e-03 GO:0072358 cardiovascular system development
1.41 9.14e-03 GO:0072359 circulatory system development
1.56 9.21e-03 GO:0030334 regulation of cell migration
1.54 9.75e-03 GO:0051960 regulation of nervous system development
1.51 9.78e-03 GO:0031401 positive regulation of protein modification process
1.61 9.83e-03 GO:0045786 negative regulation of cell cycle
1.28 1.08e-02 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.71 1.11e-02 GO:0031400 negative regulation of protein modification process
2.10 1.14e-02 GO:0006921 cellular component disassembly involved in apoptosis
1.53 1.16e-02 GO:0030029 actin filament-based process
1.57 1.20e-02 GO:0050767 regulation of neurogenesis
1.50 1.21e-02 GO:0060284 regulation of cell development
1.59 1.26e-02 GO:0051129 negative regulation of cellular component organization
1.16 1.44e-02 GO:0010468 regulation of gene expression
1.52 1.50e-02 GO:0040012 regulation of locomotion
1.57 1.57e-02 GO:0032269 negative regulation of cellular protein metabolic process
1.55 1.57e-02 GO:0051248 negative regulation of protein metabolic process
1.29 1.57e-02 GO:0040011 locomotion
1.45 1.66e-02 GO:0044271 cellular nitrogen compound biosynthetic process
1.59 1.76e-02 GO:0071156 regulation of cell cycle arrest
1.16 1.83e-02 GO:0010556 regulation of macromolecule biosynthetic process
1.54 1.88e-02 GO:0001568 blood vessel development
1.35 1.91e-02 GO:0051276 chromosome organization
1.33 1.95e-02 GO:0010628 positive regulation of gene expression
1.99 2.08e-02 GO:0008629 induction of apoptosis by intracellular signals
1.78 2.13e-02 GO:0051789 response to protein stimulus
1.49 2.31e-02 GO:0046700 heterocycle catabolic process
1.42 2.48e-02 GO:0007409 axonogenesis
1.15 2.49e-02 GO:0051171 regulation of nitrogen compound metabolic process
1.51 2.49e-02 GO:0071900 regulation of protein serine/threonine kinase activity
1.16 2.49e-02 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.48 2.62e-02 GO:0006511 ubiquitin-dependent protein catabolic process
1.51 2.67e-02 GO:0032446 protein modification by small protein conjugation
1.37 2.88e-02 GO:0023056 positive regulation of signaling
1.37 3.11e-02 GO:0010647 positive regulation of cell communication
1.95 3.11e-02 GO:0051656 establishment of organelle localization
1.55 3.26e-02 GO:0018130 heterocycle biosynthetic process
1.51 3.44e-02 GO:0010608 posttranscriptional regulation of gene expression
1.57 3.48e-02 GO:0009261 ribonucleotide catabolic process
1.18 3.54e-02 GO:0048513 organ development
1.40 4.06e-02 GO:0000279 M phase
1.46 4.09e-02 GO:0045597 positive regulation of cell differentiation
1.48 4.17e-02 GO:0008380 RNA splicing
1.53 4.18e-02 GO:0030036 actin cytoskeleton organization
1.56 4.55e-02 GO:0009143 nucleoside triphosphate catabolic process
1.56 4.55e-02 GO:0009154 purine ribonucleotide catabolic process
1.46 4.75e-02 GO:0033043 regulation of organelle organization
1.33 4.76e-02 GO:0045893 positive regulation of transcription, DNA-dependent
1.46 4.81e-02 GO:0051603 proteolysis involved in cellular protein catabolic process
1.56 4.87e-02 GO:0009146 purine nucleoside triphosphate catabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.19 8.10e-73 GO:0044424 intracellular part
1.17 1.68e-68 GO:0005622 intracellular
1.26 7.91e-66 GO:0005737 cytoplasm
1.32 9.11e-54 GO:0044444 cytoplasmic part
1.19 3.11e-51 GO:0043229 intracellular organelle
1.19 4.63e-51 GO:0043226 organelle
1.21 3.59e-49 GO:0043227 membrane-bounded organelle
1.21 1.01e-48 GO:0043231 intracellular membrane-bounded organelle
1.60 1.02e-47 GO:0005829 cytosol
1.29 5.08e-39 GO:0044446 intracellular organelle part
1.28 9.06e-39 GO:0044422 organelle part
1.47 5.99e-31 GO:0044428 nuclear part
1.45 2.13e-30 GO:0031974 membrane-enclosed lumen
1.45 8.96e-30 GO:0070013 intracellular organelle lumen
1.45 1.47e-29 GO:0043233 organelle lumen
1.24 3.28e-26 GO:0005634 nucleus
1.48 6.57e-26 GO:0031981 nuclear lumen
1.51 4.18e-20 GO:0005654 nucleoplasm
1.28 2.91e-19 GO:0032991 macromolecular complex
1.05 3.30e-19 GO:0044464 cell part
1.05 3.69e-19 GO:0005623 cell
1.29 2.30e-17 GO:0043234 protein complex
1.29 1.27e-10 GO:0031090 organelle membrane
1.50 9.47e-10 GO:0031975 envelope
1.50 1.28e-09 GO:0031967 organelle envelope
1.70 4.21e-09 GO:0048471 perinuclear region of cytoplasm
1.47 1.29e-08 GO:0044451 nucleoplasm part
1.22 2.35e-08 GO:0043228 non-membrane-bounded organelle
1.22 2.35e-08 GO:0043232 intracellular non-membrane-bounded organelle
1.37 2.64e-08 GO:0000267 cell fraction
1.29 7.88e-08 GO:0012505 endomembrane system
1.67 1.07e-07 GO:0005625 soluble fraction
1.30 8.71e-07 GO:0005739 mitochondrion
1.74 1.42e-06 GO:0005635 nuclear envelope
2.22 2.31e-06 GO:0042470 melanosome
2.22 2.31e-06 GO:0048770 pigment granule
1.59 5.67e-05 GO:0015629 actin cytoskeleton
1.37 1.01e-04 GO:0044429 mitochondrial part
1.90 1.04e-04 GO:0019867 outer membrane
1.30 2.60e-04 GO:0005794 Golgi apparatus
1.79 4.79e-04 GO:0031965 nuclear membrane
1.86 5.27e-04 GO:0031968 organelle outer membrane
1.75 7.97e-04 GO:0005912 adherens junction
1.71 8.61e-04 GO:0070161 anchoring junction
2.67 9.44e-04 GO:0042641 actomyosin
1.34 9.86e-04 GO:0015630 microtubule cytoskeleton
1.37 1.52e-03 GO:0005694 chromosome
2.14 4.39e-03 GO:0030496 midbody
2.70 4.45e-03 GO:0001725 stress fiber
1.25 4.77e-03 GO:0005783 endoplasmic reticulum
1.39 4.98e-03 GO:0005740 mitochondrial envelope
1.89 5.03e-03 GO:0016585 chromatin remodeling complex
1.85 5.04e-03 GO:0005741 mitochondrial outer membrane
1.56 6.99e-03 GO:0000228 nuclear chromosome
1.20 7.61e-03 GO:0005856 cytoskeleton
1.79 8.98e-03 GO:0030055 cell-substrate junction
1.27 9.78e-03 GO:0005626 insoluble fraction
1.38 1.11e-02 GO:0031966 mitochondrial membrane
3.04 1.40e-02 GO:0030530 heterogeneous nuclear ribonucleoprotein complex
1.78 1.68e-02 GO:0005924 cell-substrate adherens junction
2.52 1.77e-02 GO:0032432 actin filament bundle
1.23 2.01e-02 GO:0044430 cytoskeletal part
1.26 2.23e-02 GO:0005624 membrane fraction
1.78 2.36e-02 GO:0005925 focal adhesion
1.34 2.53e-02 GO:0005730 nucleolus
1.33 2.56e-02 GO:0030529 ribonucleoprotein complex
2.20 2.99e-02 GO:0017053 transcriptional repressor complex
1.63 3.66e-02 GO:0000775 chromosome, centromeric region
2.97 4.29e-02 GO:0000307 cyclin-dependent protein kinase holoenzyme complex
1.34 4.36e-02 GO:0044427 chromosomal part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.32 5.43e-79 GO:0005515 protein binding
1.14 6.70e-47 GO:0005488 binding
1.17 3.30e-12 GO:0003824 catalytic activity
1.27 2.90e-10 GO:0000166 nucleotide binding
1.49 1.32e-09 GO:0042802 identical protein binding
1.45 3.29e-08 GO:0019899 enzyme binding
1.25 5.34e-07 GO:0032553 ribonucleotide binding
1.25 5.34e-07 GO:0032555 purine ribonucleotide binding
1.25 9.49e-07 GO:0017076 purine nucleotide binding
1.25 1.22e-06 GO:0035639 purine ribonucleoside triphosphate binding
1.54 1.96e-06 GO:0019904 protein domain specific binding
1.58 2.98e-06 GO:0000988 protein binding transcription factor activity
1.58 2.98e-06 GO:0000989 transcription factor binding transcription factor activity
1.57 4.78e-06 GO:0003712 transcription cofactor activity
1.25 3.72e-05 GO:0032559 adenyl ribonucleotide binding
1.40 4.68e-05 GO:0046983 protein dimerization activity
1.25 5.45e-05 GO:0030554 adenyl nucleotide binding
1.48 1.08e-04 GO:0042803 protein homodimerization activity
1.24 1.54e-04 GO:0005524 ATP binding
1.33 2.29e-04 GO:0003723 RNA binding
1.63 8.18e-04 GO:0003713 transcription coactivator activity
1.97 8.19e-03 GO:0031625 ubiquitin protein ligase binding
1.65 1.38e-02 GO:0004721 phosphoprotein phosphatase activity
1.26 1.41e-02 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.47 1.59e-02 GO:0008134 transcription factor binding
1.46 1.74e-02 GO:0016879 ligase activity, forming carbon-nitrogen bonds
1.27 3.57e-02 GO:0016817 hydrolase activity, acting on acid anhydrides
1.27 3.74e-02 GO:0016301 kinase activity
1.41 3.83e-02 GO:0042578 phosphoric ester hydrolase activity
1.27 3.83e-02 GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
1.27 4.11e-02 GO:0016462 pyrophosphatase activity
1.78 4.17e-02 GO:0051427 hormone receptor binding
1.28 4.22e-02 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.32 4.78e-02 GO:0008092 cytoskeletal protein binding