Motif ID: POU3F1..4.p2

Z-value: 0.849


Transcription factors associated with POU3F1..4.p2:

Gene SymbolEntrez IDGene Name
POU3F1 5453 POU class 3 homeobox 1
POU3F2 5454 POU class 3 homeobox 2
POU3F3 5455 POU class 3 homeobox 3
POU3F4 5456 POU class 3 homeobox 4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
POU3F3chr2_+_1054717450.384.3e-09Click!
POU3F4chrX_+_827632680.363.0e-08Click!
POU3F1chr1_-_385124460.291.1e-05Click!
POU3F2chr6_+_992825970.243.1e-04Click!


Activity profile for motif POU3F1..4.p2.

activity profile for motif POU3F1..4.p2


Sorted Z-values histogram for motif POU3F1..4.p2

Sorted Z-values for motif POU3F1..4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of POU3F1..4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_+_150399980 19.537 NM_002084
GPX3
glutathione peroxidase 3 (plasma)
chr5_+_40909617 17.330 C7
complement component 7
chr5_+_40909558 16.172 NM_000587
C7
complement component 7
chr2_+_189839113 15.427 COL3A1
collagen, type III, alpha 1
chr2_+_189839132 13.964 COL3A1
collagen, type III, alpha 1
chr6_+_121756744 12.725 NM_000165
GJA1
gap junction protein, alpha 1, 43kDa
chr12_-_91505215 11.909 LUM
lumican
chr4_+_74270832 11.857 ALB
albumin
chr4_+_88896868 11.697 SPP1
secreted phosphoprotein 1
chr2_+_189839078 10.990 NM_000090
COL3A1
collagen, type III, alpha 1
chr6_-_46889620 10.948 NM_001098518
GPR116
G protein-coupled receptor 116
chr4_+_88896838 10.228 SPP1
secreted phosphoprotein 1
chr3_-_123339178 10.149 MYLK
myosin light chain kinase
chr12_-_16759939 9.340 NM_001243613
LMO3
LIM domain only 3 (rhombotin-like 2)
chr12_-_16759733 8.949 NM_001243610
LMO3
LIM domain only 3 (rhombotin-like 2)
chrX_+_65384078 8.165 NM_001130860
NM_014799
HEPH

hephaestin

chr4_-_88450601 7.651 NM_001128310
NM_004684
SPARCL1

SPARC-like 1 (hevin)

chr4_+_74269971 7.288 NM_000477
ALB
albumin
chr12_-_9268513 6.867 A2M
alpha-2-macroglobulin
chr8_+_39771327 6.445 NM_002164
IDO1
indoleamine 2,3-dioxygenase 1
chr12_-_9268475 6.342 A2M
alpha-2-macroglobulin
chr4_+_88896801 6.191 NM_000582
NM_001040058
NM_001040060
NM_001251829
NM_001251830
SPP1




secreted phosphoprotein 1




chrX_+_100805415 6.092 NM_016608
ARMCX1
armadillo repeat containing, X-linked 1
chr4_+_169418167 5.986 NM_001166108
NM_016081
PALLD

palladin, cytoskeletal associated protein

chr5_+_140729723 5.898 NM_018922
NM_032095
PCDHGB1

protocadherin gamma subfamily B, 1

chr12_-_7245048 5.850 C1R
complement component 1, r subcomponent
chr15_-_56209305 5.607 NM_198400
NEDD4
neural precursor cell expressed, developmentally down-regulated 4
chr17_+_32582295 5.508 NM_002982
CCL2
chemokine (C-C motif) ligand 2
chr6_-_131291480 5.443 NM_001199389
EPB41L2
erythrocyte membrane protein band 4.1-like 2
chr5_-_41213513 5.429 NM_000065
C6
complement component 6
chr4_-_100242487 5.370 NM_000668
ADH1A
ADH1B
alcohol dehydrogenase 1A (class I), alpha polypeptide
alcohol dehydrogenase 1B (class I), beta polypeptide
chr1_+_171283372 5.356 NM_002022
FMO4
flavin containing monooxygenase 4
chr2_-_163008913 5.275 NM_002054
GCG
glucagon
chrX_+_102883891 5.250 NM_001006639
NM_004780
TCEAL1

transcription elongation factor A (SII)-like 1

chr3_-_123339423 5.237 NM_053031
NM_053032
MYLK

myosin light chain kinase

chr3_-_168865521 5.226 NM_001164000
MECOM
MDS1 and EVI1 complex locus
chr3_+_148447966 5.004 NM_032049
AGTR1
angiotensin II receptor, type 1
chr17_-_64225496 4.944 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr17_-_46682333 4.659 NM_018952
HOXB6
homeobox B6
chr18_+_61442611 4.625 NM_003784
SERPINB7
serpin peptidase inhibitor, clade B (ovalbumin), member 7
chr16_+_1728290 4.608 HN1L
hematological and neurological expressed 1-like
chr17_-_2996289 4.590 NM_002548
OR1D2
olfactory receptor, family 1, subfamily D, member 2
chr16_+_4845265 4.516 NM_001253793
NM_001253794
LOC440335

uncharacterized LOC440335

chr11_+_71903172 4.449 NM_016729
FOLR1
folate receptor 1 (adult)
chr7_-_137028433 4.405 PTN
pleiotrophin
chr12_-_71031174 4.358 NM_001109754
PTPRB
protein tyrosine phosphatase, receptor type, B
chr7_-_137028370 4.295 PTN
pleiotrophin
chr6_-_169654047 4.285 NM_003247
THBS2
thrombospondin 2
chr2_-_163099877 4.035 NM_004460
FAP
fibroblast activation protein, alpha
chr6_+_43738394 3.956 VEGFA
vascular endothelial growth factor A
chr7_-_83278478 3.824 NM_012431
SEMA3E
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
chr9_+_137967366 3.790 OLFM1
olfactomedin 1
chr13_-_45011389 3.787 NM_001243797
TSC22D1
TSC22 domain family, member 1
chr5_+_34684611 3.745 NM_001145521
NM_001145525
RAI14

retinoic acid induced 14

chr6_+_27925018 3.684 NM_012367
OR2B6
olfactory receptor, family 2, subfamily B, member 6
chr4_-_87028805 3.609 NM_138981
MAPK10
mitogen-activated protein kinase 10
chr4_+_123844210 3.558 NM_145207
SPATA5
spermatogenesis associated 5
chr9_-_75568232 3.548 NM_000689
ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr15_+_71184781 3.351 NM_001199017
NM_017691
NM_001199018
LRRC49


leucine rich repeat containing 49


chr1_-_156399183 3.333 NM_006365
C1orf61
chromosome 1 open reading frame 61
chr4_+_106631966 3.325 NM_001031720
GSTCD
glutathione S-transferase, C-terminal domain containing
chr1_-_173174611 3.322 TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr12_+_21168629 3.279 NM_001009562
SLCO1B7
solute carrier organic anion transporter family, member 1B7 (non-functional)
chr12_+_100897137 3.250 NM_001206992
NM_001206993
NR1H4

nuclear receptor subfamily 1, group H, member 4

chr5_-_141338626 3.203 NM_016580
PCDH12
protocadherin 12
chr12_-_91398744 3.164 EPYC
epiphycan
chr1_-_144997110 3.150 NM_001195260
PDE4DIP
phosphodiesterase 4D interacting protein
chr5_+_140810181 3.136 PCDHGA12
protocadherin gamma subfamily A, 12
chr13_-_78492906 3.114 NM_001122659
NM_003991
EDNRB

endothelin receptor type B

chr8_+_104831415 3.113 NM_014677
RIMS2
regulating synaptic membrane exocytosis 2
chr11_-_58499368 3.111 NM_005838
NM_201648
GLYAT

glycine-N-acyltransferase

chr9_+_137967267 3.103 OLFM1
olfactomedin 1
chr12_-_9268522 3.072 NM_000014
A2M
alpha-2-macroglobulin
chr1_+_196788860 3.070 NM_002113
CFHR1
complement factor H-related 1
chr10_+_102123420 3.064


chrX_-_15620191 2.960 NM_021804
ACE2
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
chr7_+_45933096 2.952


chrX_+_54834775 2.887 NM_014599
MAGED2
melanoma antigen family D, 2
chr1_-_182922504 2.856 NM_030933
SHCBP1L
SHC SH2-domain binding protein 1-like
chr13_-_38172862 2.809 NM_001135934
NM_001135935
NM_001135936
NM_006475
POSTN



periostin, osteoblast specific factor



chr8_-_66701175 2.807 NM_002603
PDE7A
phosphodiesterase 7A
chr12_-_371994 2.800 NM_001190997
NM_001243392
NM_016615
SLC6A13


solute carrier family 6 (neurotransmitter transporter, GABA), member 13


chrX_+_48114796 2.770 NM_005635
SSX1
synovial sarcoma, X breakpoint 1
chrX_+_114827818 2.696 NM_001136025
NM_001172335
PLS3

plastin 3

chr12_+_54422193 2.644 NM_004503
HOXC6
homeobox C6
chr12_-_16759430 2.634 LMO3
LIM domain only 3 (rhombotin-like 2)
chr21_-_36421461 2.630 RUNX1
runt-related transcription factor 1
chr1_+_203444955 2.601 PRELP
proline/arginine-rich end leucine-rich repeat protein
chr5_+_140792507 2.597 NM_018913
NM_032090
PCDHGA10

protocadherin gamma subfamily A, 10

chr5_+_140810126 2.596 NM_003735
NM_032094
PCDHGA12

protocadherin gamma subfamily A, 12

chr19_-_14939275 2.553 NM_017506
OR7A5
olfactory receptor, family 7, subfamily A, member 5
chr1_-_13452655 2.534 NM_001024661
NM_001099854
PRAMEF13
PRAMEF14
PRAME family member 13
PRAME family member 14
chr2_-_77749335 2.523 NM_001134745
NM_024993
LRRTM4

leucine rich repeat transmembrane neuronal 4

chr2_-_201936386 2.508 FAM126B
family with sequence similarity 126, member B
chr7_-_83270746 2.501 NM_001178129
SEMA3E
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
chr7_+_130126035 2.495 NM_177524
MEST
mesoderm specific transcript homolog (mouse)
chr3_+_49568370 2.491 DAG1
dystroglycan 1 (dystrophin-associated glycoprotein 1)
chrX_-_10535476 2.456 NM_001193278
NM_001193279
NM_001193280
NM_001193281
MID1



midline 1 (Opitz/BBB syndrome)



chrX_+_64708614 2.442 NM_001010888
ZC3H12B
zinc finger CCCH-type containing 12B
chr11_-_85469043 2.441 NM_001162951
NM_001162953
SYTL2

synaptotagmin-like 2

chr5_-_147211141 2.397 SPINK1
serine peptidase inhibitor, Kazal type 1
chr6_+_46761093 2.393 NM_005588
MEP1A
meprin A, alpha (PABA peptide hydrolase)
chr8_-_17579729 2.378 NM_001001931
MTUS1
microtubule associated tumor suppressor 1
chr4_-_88450243 2.362 SPARCL1
SPARC-like 1 (hevin)
chr18_+_61575203 2.280 SERPINB10
serpin peptidase inhibitor, clade B (ovalbumin), member 10
chrX_+_91089658 2.271 NM_014522
NM_032968
NM_032969
PCDH11X


protocadherin 11 X-linked


chr3_+_11267666 2.256 NM_001098211
HRH1
histamine receptor H1
chr17_-_66951381 2.241 NM_007168
ABCA8
ATP-binding cassette, sub-family A (ABC1), member 8
chr3_-_114343052 2.228 NM_001164347
ZBTB20
zinc finger and BTB domain containing 20
chr10_-_5060191 2.202 NM_001354
NM_205845
AKR1C2

aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)

chr7_-_126883568 2.198 NM_000845
GRM8
glutamate receptor, metabotropic 8
chr7_-_80141241 2.191 NM_001102386
GNAT3
guanine nucleotide binding protein, alpha transducing 3
chr1_-_163113938 2.176 RGS5
regulator of G-protein signaling 5
chr10_+_95848811 2.131 NM_001165979
PLCE1
phospholipase C, epsilon 1
chr5_+_140743755 2.114 NM_018918
NM_032054
PCDHGA5

protocadherin gamma subfamily A, 5

chr15_-_23932410 2.106 NM_002487
NDN
necdin homolog (mouse)
chr10_-_69425356 2.093 NM_001127384
CTNNA3
catenin (cadherin-associated protein), alpha 3
chr9_-_21187529 2.087 NM_021068
IFNA4
interferon, alpha 4
chr11_-_71781091 2.055 NUMA1
nuclear mitotic apparatus protein 1
chr13_-_36429798 2.042 NM_001195415
NM_001195416
NM_001195430
DCLK1


doublecortin-like kinase 1


chrX_+_67913479 2.032 NM_001142504
STARD8
StAR-related lipid transfer (START) domain containing 8
chr1_+_15986363 2.027 NM_006511
RSC1A1
regulatory solute carrier protein, family 1, member 1
chr5_-_58652671 2.026 NM_001197219
PDE4D
phosphodiesterase 4D, cAMP-specific
chr7_-_124405680 2.013 NM_005302
GPR37
G protein-coupled receptor 37 (endothelin receptor type B-like)
chr7_-_137028275 2.002 PTN
pleiotrophin
chr13_+_24844846 1.964 SPATA13
spermatogenesis associated 13
chr13_-_78493902 1.961 NM_001201397
EDNRB
endothelin receptor type B
chr12_+_57984992 1.936 PIP4K2C
phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
chr4_-_72649734 1.910 NM_000583
GC
group-specific component (vitamin D binding protein)
chr6_+_28234787 1.885 NM_001023560
NM_001111039
NM_152736
ZNF187


zinc finger protein 187


chr16_-_90039239 1.875 NM_145039
CENPBD1
CENPB DNA-binding domains containing 1
chr4_+_88720701 1.837 NM_004967
IBSP
integrin-binding sialoprotein
chr13_+_102104941 1.831 NM_004791
ITGBL1
integrin, beta-like 1 (with EGF-like repeat domains)
chr19_+_56186569 1.827 EPN1
epsin 1
chr3_-_99594915 1.824 NM_014890
FILIP1L
filamin A interacting protein 1-like
chr5_+_149340287 1.808 NM_000112
SLC26A2
solute carrier family 26 (sulfate transporter), member 2
chr16_+_6823809 1.802 NM_001142334
RBFOX1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr11_-_8954534 1.792 NM_020643
C11orf16
chromosome 11 open reading frame 16
chr1_-_93399531 1.786


chr20_+_9458460 1.759 PLCB4
phospholipase C, beta 4
chr17_+_42925278 1.759 NM_016438
HIGD1B
HIG1 hypoxia inducible domain family, member 1B
chr6_+_27107060 1.739 NM_003495
HIST2H4B
HIST1H4I
histone cluster 2, H4b
histone cluster 1, H4i
chr4_-_155533800 1.731 FGG
fibrinogen gamma chain
chr3_-_194991778 1.722 NM_152531
XXYLT1
xyloside xylosyltransferase 1
chr5_+_71502700 1.711 MAP1B
microtubule-associated protein 1B
chr5_-_157002705 1.699


chr18_-_53068755 1.695 TCF4
transcription factor 4
chr3_+_121613170 1.691 NM_001145998
NM_021082
SLC15A2

solute carrier family 15 (H+/peptide transporter), member 2

chr4_-_110723127 1.690 CFI
complement factor I
chr1_+_150230168 1.687 NM_012113
CA14
carbonic anhydrase XIV
chrX_-_137821514 1.684 NM_033642
FGF13
fibroblast growth factor 13
chr3_-_46718898 1.679 NM_182775
ALS2CL
ALS2 C-terminal like
chr5_-_75919051 1.672 NM_004101
F2RL2
coagulation factor II (thrombin) receptor-like 2
chr9_-_111618209 1.670 NM_006686
ACTL7B
actin-like 7B
chr15_+_42066690 1.639 MAPKBP1
mitogen-activated protein kinase binding protein 1
chr3_+_153838791 1.633 NM_001251962
ARHGEF26
Rho guanine nucleotide exchange factor (GEF) 26
chr7_-_137028533 1.630 NM_002825
PTN
pleiotrophin
chr12_+_12224401 1.628 NM_030766
NM_138722
BCL2L14

BCL2-like 14 (apoptosis facilitator)

chr15_+_59908908 1.610 GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr3_-_114102488 1.596 NM_001164342
ZBTB20
zinc finger and BTB domain containing 20
chr15_+_69307033 1.592 NM_001184779
NM_024505
NOX5

NADPH oxidase, EF-hand calcium binding domain 5

chr5_+_140771482 1.589 NM_014004
NM_032088
PCDHGA8

protocadherin gamma subfamily A, 8

chr4_+_71108304 1.589 NM_005212
CSN3
casein kappa
chrX_+_110366304 1.587 NM_001128168
NM_001128172
NM_001128173
PAK3


p21 protein (Cdc42/Rac)-activated kinase 3


chr11_-_118123001 1.556 NM_198275
MPZL3
myelin protein zero-like 3
chr22_+_18043147 1.550 NM_031481
SLC25A18
solute carrier family 25 (mitochondrial carrier), member 18
chr1_+_196912910 1.535 NM_005666
CFHR2
complement factor H-related 2
chr1_+_182419255 1.532 NM_001137669
RGSL1
regulator of G-protein signaling like 1
chr1_+_12916940 1.526 NM_023014
PRAMEF2
PRAME family member 2
chr4_-_100273831 1.505 NM_000669
ADH1C
alcohol dehydrogenase 1C (class I), gamma polypeptide
chr6_-_49834188 1.484 NM_001131
NM_170609
CRISP1

cysteine-rich secretory protein 1

chr21_-_39956823 1.484 NM_001243429
ERG
v-ets erythroblastosis virus E26 oncogene homolog (avian)
chr19_-_4400357 1.480 NM_001199944
SH3GL1
SH3-domain GRB2-like 1
chr7_+_102023016 1.475


chr10_+_102121371 1.465 SCD
stearoyl-CoA desaturase (delta-9-desaturase)
chr1_+_78470593 1.458 NM_007034
DNAJB4
DnaJ (Hsp40) homolog, subfamily B, member 4
chr10_+_15085894 1.457 NM_001039702
NM_018324
OLAH

oleoyl-ACP hydrolase

chr21_-_36421195 1.456 RUNX1
runt-related transcription factor 1
chr6_-_138820580 1.454


chr19_+_16830786 1.432 NM_001007525
NWD1
NACHT and WD repeat domain containing 1
chr4_-_110723334 1.427 NM_000204
CFI
complement factor I
chr7_-_87342569 1.419 NM_000927
ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr2_-_31352489 1.416 NM_001253827
GALNT14
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)
chr2_-_209010876 1.415 NM_005210
CRYGB
crystallin, gamma B
chr8_-_13372183 1.412 NM_024767
NM_182643
DLC1

deleted in liver cancer 1

chr8_-_146202727 1.409 ZNF252
zinc finger protein 252
chr12_-_58135853 1.386 NM_014770
AGAP2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chrX_+_105937067 1.385 NM_024539
RNF128
ring finger protein 128
chr17_+_28268622 1.380 NM_198529
EFCAB5
EF-hand calcium binding domain 5
chr9_+_131388167 1.369 SPTAN1
spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
chr6_-_136788012 1.367 NM_001198615
MAP7
microtubule-associated protein 7
chr16_+_81272293 1.364 NM_017429
BCMO1
beta-carotene 15,15'-monooxygenase 1
chrX_-_32430370 1.363 NM_004011
NM_004012
DMD

dystrophin

chr2_+_152214105 1.358 NM_007115
TNFAIP6
tumor necrosis factor, alpha-induced protein 6
chrX_+_144908927 1.355 NM_004709
CXorf1
chromosome X open reading frame 1
chr4_-_26491888 1.353 NM_000730
CCKAR
cholecystokinin A receptor
chr9_+_117904096 1.347 NM_017418
DEC1
deleted in esophageal cancer 1
chr1_+_12851545 1.329 NM_023013
PRAMEF1
PRAME family member 1
chr5_+_81267797 1.328 NM_001131028
NM_031482
ATG10

ATG10 autophagy related 10 homolog (S. cerevisiae)

chr4_+_156824846 1.322 NM_005651
TDO2
tryptophan 2,3-dioxygenase

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.37 1.13e-05 GO:0050896 response to stimulus
6.77 2.31e-04 GO:0072376 protein activation cascade
1.37 2.91e-04 GO:0032501 multicellular organismal process
1.17 3.24e-04 GO:0009987 cellular process
1.43 5.58e-04 GO:0051716 cellular response to stimulus
5.59 7.30e-04 GO:0006959 humoral immune response
4.14 2.41e-03 GO:0006805 xenobiotic metabolic process
4.14 2.41e-03 GO:0071466 cellular response to xenobiotic stimulus
4.11 2.67e-03 GO:0009410 response to xenobiotic stimulus
1.59 4.13e-03 GO:0042221 response to chemical stimulus
2.35 5.88e-03 GO:0007186 G-protein coupled receptor protein signaling pathway
7.86 8.72e-03 GO:0002455 humoral immune response mediated by circulating immunoglobulin
1.41 1.14e-02 GO:0023052 signaling
15.64 1.26e-02 GO:0006067 ethanol metabolic process
15.64 1.26e-02 GO:0006069 ethanol oxidation
15.64 1.26e-02 GO:0034308 primary alcohol metabolic process
7.44 1.36e-02 GO:0007205 activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway
2.06 1.43e-02 GO:0007155 cell adhesion
2.06 1.43e-02 GO:0022610 biological adhesion
1.41 2.51e-02 GO:0007165 signal transduction
2.71 3.53e-02 GO:0016337 cell-cell adhesion
6.55 3.66e-02 GO:0006956 complement activation
7.77 3.72e-02 GO:0006958 complement activation, classical pathway

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.63 4.65e-09 GO:0005615 extracellular space
1.79 2.24e-07 GO:0044459 plasma membrane part
2.24 3.07e-07 GO:0044421 extracellular region part
1.50 5.45e-07 GO:0071944 cell periphery
1.48 3.49e-06 GO:0005886 plasma membrane
1.71 1.76e-05 GO:0005576 extracellular region
1.89 5.72e-04 GO:0000267 cell fraction
1.81 9.67e-04 GO:0005887 integral to plasma membrane
2.00 1.33e-03 GO:0005626 insoluble fraction
1.78 1.75e-03 GO:0031226 intrinsic to plasma membrane
1.22 2.89e-03 GO:0016020 membrane
19.66 5.55e-03 GO:0005579 membrane attack complex
1.94 6.36e-03 GO:0005624 membrane fraction
1.23 2.08e-02 GO:0044425 membrane part

Gene overrepresentation in function category:

enrichment   p-value GO term description
19.11 8.92e-04 GO:0004022 alcohol dehydrogenase (NAD) activity
2.08 6.15e-03 GO:0005509 calcium ion binding
6.26 1.29e-02 GO:0043498 cell surface binding
4.30 1.80e-02 GO:0008081 phosphoric diester hydrolase activity
3.25 2.38e-02 GO:0001871 pattern binding
3.25 2.38e-02 GO:0030247 polysaccharide binding
10.75 2.61e-02 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity
3.28 3.75e-02 GO:0005539 glycosaminoglycan binding