Motif ID: REST.p3

Z-value: 3.279


Transcription factors associated with REST.p3:

Gene SymbolEntrez IDGene Name
REST 5978 RE1-silencing transcription factor

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
RESTchr4_+_57775064,
chr4_+_57774035
-0.671.2e-29Click!


Activity profile for motif REST.p3.

activity profile for motif REST.p3


Sorted Z-values histogram for motif REST.p3

Sorted Z-values for motif REST.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of REST.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr20_+_44657812 160.702 NM_020708
SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5
chr4_+_158141735 154.459 NM_000826
NM_001083619
NM_001083620
GRIA2


glutamate receptor, ionotropic, AMPA 2


chr20_+_44657858 151.763 SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5
chr20_+_5891973 140.293 NM_001819
CHGB
chromogranin B (secretogranin 1)
chr12_+_175872 135.359 NM_001170738
IQSEC3
IQ motif and Sec7 domain 3
chrX_-_47479229 134.497 NM_006950
NM_133499
SYN1

synapsin I

chr14_+_93389444 127.147 NM_001275
CHGA
chromogranin A (parathyroid secretory protein 1)
chr3_-_187388105 125.702 NM_001048
SST
somatostatin
chr1_+_33352071 121.804 NM_002143
HPCA
hippocalcin
chr14_+_93389491 118.937 CHGA
chromogranin A (parathyroid secretory protein 1)
chr17_+_42385780 110.196 NM_001144825
NM_001144826
NM_006695
RUNDC3A


RUN domain containing 3A


chr12_+_113229548 105.900 NM_001143854
NM_014954
RPH3A

rabphilin 3A homolog (mouse)

chr11_-_123524881 100.407 SCN3B
sodium channel, voltage-gated, type III, beta
chr1_-_241520467 96.953 NM_002924
RGS7
regulator of G-protein signaling 7
chr16_+_24267474 90.552 CACNG3
calcium channel, voltage-dependent, gamma subunit 3
chr8_-_57358511 88.354 NM_006211
PENK
proenkephalin
chr17_+_30813928 86.272 NM_003885
CDK5R1
cyclin-dependent kinase 5, regulatory subunit 1 (p35)
chrX_-_49056638 84.939 NM_003179
SYP
synaptophysin
chr11_-_66115016 83.534 NM_006876
B3GNT1
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
chr14_-_51561657 80.899 TRIM9
tripartite motif containing 9
chr15_-_83378488 75.115 NM_004644
AP3B2
adaptor-related protein complex 3, beta 2 subunit
chr16_+_24267672 74.936 CACNG3
calcium channel, voltage-dependent, gamma subunit 3
chr11_+_45907046 71.884 NM_005456
MAPK8IP1
mitogen-activated protein kinase 8 interacting protein 1
chr11_+_45907198 70.301 MAPK8IP1
mitogen-activated protein kinase 8 interacting protein 1
chr10_-_50970321 67.745 NM_001143996
NM_001143997
NM_018245
OGDHL


oxoglutarate dehydrogenase-like


chr10_-_102790850 66.807 PDZD7
PDZ domain containing 7
chr15_+_75287829 63.321 NM_001178111
NM_001178112
NM_138967
SCAMP5


secretory carrier membrane protein 5


chr11_-_75141015 61.216 KLHL35
kelch-like 35 (Drosophila)
chr10_+_26505593 57.618 GAD2
glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
chr10_-_102790877 57.369 NM_001195263
NM_024895
PDZD7

PDZ domain containing 7

chr19_-_55691468 56.445 NM_003180
SYT5
synaptotagmin V
chr8_-_91094924 54.120 NM_004929
CALB1
calbindin 1, 28kDa
chr16_+_5008317 50.248 NM_014692
SEC14L5
SEC14-like 5 (S. cerevisiae)
chr10_+_26505235 50.115 NM_000818
NM_001134366
GAD2

glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)

chr3_-_48700317 46.005 NM_001407
CELSR3
cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila)
chr17_-_3337134 41.298 NM_003554
OR1E2
olfactory receptor, family 1, subfamily E, member 2
chr3_+_62305395 41.255 NM_020685
C3orf14
chromosome 3 open reading frame 14
chr1_-_241520384 39.959 RGS7
regulator of G-protein signaling 7
chr6_+_154360442 39.803 NM_000914
NM_001008503
NM_001008504
NM_001008505
NM_001145282
NM_001145283
NM_001145284
NM_001145285
NM_001145286
OPRM1








opioid receptor, mu 1








chr3_+_62304667 38.894 C3orf14
chromosome 3 open reading frame 14
chrX_-_153141398 37.699 NM_000425
NM_001143963
NM_024003
L1CAM


L1 cell adhesion molecule


chr9_-_139096954 35.214 NM_178138
LHX3
LIM homeobox 3
chr6_+_25652373 33.501 NM_006998
SCGN
secretagogin, EF-hand calcium binding protein
chr2_+_46524448 30.937 NM_001430
EPAS1
endothelial PAS domain protein 1
chr9_+_140033588 30.738 NM_000832
NM_001185090
NM_001185091
NM_007327
NM_021569
GRIN1




glutamate receptor, ionotropic, N-methyl D-aspartate 1




chr4_-_175750377 30.011 NM_001042543
NM_006529
GLRA3

glycine receptor, alpha 3

chr6_+_44238479 28.192 NM_001137560
TMEM151B
transmembrane protein 151B
chr20_-_60795270 26.939 NM_007232
HRH3
histamine receptor H3
chr2_-_51259536 26.747 NM_001135659
NM_004801
NRXN1

neurexin 1

chr17_-_3301703 24.791 NM_003553
OR1E1
olfactory receptor, family 1, subfamily E, member 1
chr1_-_175712669 24.361 NM_003285
TNR
tenascin R (restrictin, janusin)
chr19_-_3971032 24.163 DAPK3
death-associated protein kinase 3
chr11_+_62380212 23.032 NM_000327
ROM1
retinal outer segment membrane protein 1
chr15_+_69222838 22.378 NM_145658
NM_001184780
SPESP1
NOX5
sperm equatorial segment protein 1
NADPH oxidase, EF-hand calcium binding domain 5
chr11_-_125773086 21.790 NM_031307
PUS3
pseudouridylate synthase 3
chr1_+_154540250 21.390 NM_000748
CHRNB2
cholinergic receptor, nicotinic, beta 2 (neuronal)
chr19_-_3971089 20.111 DAPK3
death-associated protein kinase 3
chr6_+_110300197 17.905 NM_005284
GPR6
G protein-coupled receptor 6
chr11_+_22359666 17.618 NM_020346
SLC17A6
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
chr16_+_3019341 17.282 NM_152341
PAQR4
progestin and adipoQ receptor family member IV
chr2_-_220083658 16.404 ABCB6
ATP-binding cassette, sub-family B (MDR/TAP), member 6
chr5_-_151304322 16.054 NM_000171
NM_001146040
GLRA1

glycine receptor, alpha 1

chr10_+_102790984 15.856 NM_030971
SFXN3
sideroflexin 3
chr2_-_27531113 15.072 NM_003353
UCN
urocortin
chr7_-_100808832 14.789 NM_003378
VGF
VGF nerve growth factor inducible
chr5_+_175298604 14.770 CPLX2
complexin 2
chr19_+_34175433 14.215 NM_022467
CHST8
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
chr14_-_94759594 14.165 NM_001100607
SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr2_-_220083394 14.150 ABCB6
ATP-binding cassette, sub-family B (MDR/TAP), member 6
chrX_+_153237990 14.002 NM_003492
TMEM187
transmembrane protein 187
chr20_+_13765645 13.675 NM_001039375
NM_024120
C20orf7

chromosome 20 open reading frame 7

chr15_-_27018917 13.356 NM_021912
GABRB3
gamma-aminobutyric acid (GABA) A receptor, beta 3
chr1_-_151689246 12.715 NM_007185
CELF3
CUGBP, Elav-like family member 3
chr3_+_120627026 9.751 NM_014980
STXBP5L
syntaxin binding protein 5-like
chr5_+_141303366 8.520 NM_001142603
NM_014773
KIAA0141

KIAA0141

chr9_+_138453599 8.422 NM_001018049
NM_002571
PAEP

progestagen-associated endometrial protein

chr5_+_71014989 8.181 NM_004291
CARTPT
CART prepropeptide
chr11_+_637268 7.451 NM_000797
DRD4
dopamine receptor D4
chr7_+_145813452 6.851 NM_014141
CNTNAP2
contactin associated protein-like 2
chr8_+_68864341 6.843 PREX2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chrX_-_153141284 6.802 L1CAM
L1 cell adhesion molecule
chr5_+_33936490 6.395 NM_016568
RXFP3
relaxin/insulin-like family peptide receptor 3
chr5_+_141303463 5.994 KIAA0141
KIAA0141
chr9_-_123812535 5.510 NM_001735
C5
complement component 5
chr1_-_20834609 4.821 NM_024544
MUL1
mitochondrial E3 ubiquitin protein ligase 1
chr21_-_35828038 4.746 NM_001127670
KCNE1
potassium voltage-gated channel, Isk-related family, member 1
chr1_+_212606194 3.973 NM_013349
NENF
neudesin neurotrophic factor
chr12_+_71833518 3.872 LGR5
leucine-rich repeat containing G protein-coupled receptor 5
chr6_+_153071931 3.749 NM_003381
NM_194435
VIP

vasoactive intestinal peptide

chr9_-_74061819 3.727 TRPM3
transient receptor potential cation channel, subfamily M, member 3
chr10_-_44880452 3.467 NM_000609
NM_001033886
NM_001178134
NM_199168
CXCL12



chemokine (C-X-C motif) ligand 12



chr5_+_69696805 3.256 SMA4
glucuronidase, beta pseudogene
chr1_-_20834516 2.983 MUL1
mitochondrial E3 ubiquitin protein ligase 1
chr22_+_20008633 2.760 C22orf25
chromosome 22 open reading frame 25
chr5_+_175298538 2.736 CPLX2
complexin 2
chr16_+_2510080 2.550 NM_025108
C16orf59
chromosome 16 open reading frame 59
chr6_+_43149905 2.186 NM_015089
CUL9
cullin 9
chr11_-_128807712 1.945 NM_001195194
TP53AIP1
tumor protein p53 regulated apoptosis inducing protein 1
chr5_-_69881965 1.370 SMA4
glucuronidase, beta pseudogene
chr7_+_134832765 1.222 NM_018295
TMEM140
transmembrane protein 140
chr20_+_57428035 1.059 NM_001077490
NM_080425
GNAS

GNAS complex locus

chr3_+_193853937 0.982 HES1
hairy and enhancer of split 1, (Drosophila)
chr1_+_171750829 0.839 METTL13
methyltransferase like 13
chr9_-_131038196 0.822 NM_004486
GOLGA2
golgin A2
chr11_-_6676851 0.816 NM_003737
DCHS1
dachsous 1 (Drosophila)
chr1_-_13184325 0.681 NM_001136561
LOC440563
heterogeneous nuclear ribonucleoprotein C-like
chr5_-_135701163 0.542 NM_001167576
NM_001167577
NM_020389
TRPC7


transient receptor potential cation channel, subfamily C, member 7


chr1_+_171750807 0.470 METTL13
methyltransferase like 13
chr11_+_32112607 0.414 RCN1
reticulocalbin 1, EF-hand calcium binding domain
chr1_+_25071906 0.042 CLIC4
chloride intracellular channel 4

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
8.99 1.97e-11 GO:0019226 transmission of nerve impulse
8.99 1.97e-11 GO:0035637 multicellular organismal signaling
9.59 2.97e-11 GO:0007268 synaptic transmission
4.72 2.22e-10 GO:0050877 neurological system process
4.04 1.61e-09 GO:0003008 system process
5.87 4.78e-08 GO:0007267 cell-cell signaling
6.86 1.44e-07 GO:0007186 G-protein coupled receptor protein signaling pathway
4.65 1.06e-06 GO:0007154 cell communication
2.41 3.78e-06 GO:0023052 signaling
13.22 1.24e-05 GO:0031644 regulation of neurological system process
6.50 4.27e-05 GO:0046903 secretion
6.40 5.07e-05 GO:0055082 cellular chemical homeostasis
7.69 8.61e-05 GO:0007610 behavior
12.98 8.90e-05 GO:0051969 regulation of transmission of nerve impulse
1.96 9.08e-05 GO:0032501 multicellular organismal process
6.12 2.67e-04 GO:0006873 cellular ion homeostasis
5.05 2.85e-04 GO:0048878 chemical homeostasis
5.30 4.36e-04 GO:0019725 cellular homeostasis
5.65 6.21e-04 GO:0050801 ion homeostasis
4.02 8.44e-04 GO:0006811 ion transport
2.35 8.51e-04 GO:0006810 transport
2.32 1.18e-03 GO:0051234 establishment of localization
2.18 1.21e-03 GO:0051179 localization
6.52 1.46e-03 GO:0044057 regulation of system process
2.61 2.06e-03 GO:0065008 regulation of biological quality
33.52 2.77e-03 GO:0060078 regulation of postsynaptic membrane potential
6.23 6.79e-03 GO:0032940 secretion by cell
11.39 7.09e-03 GO:0003001 generation of a signal involved in cell-cell signaling
11.39 7.09e-03 GO:0023061 signal release
10.78 9.71e-03 GO:0050804 regulation of synaptic transmission
46.40 1.63e-02 GO:0051954 positive regulation of amine transport
3.55 1.64e-02 GO:0042592 homeostatic process
21.75 1.64e-02 GO:0051952 regulation of amine transport
9.51 1.98e-02 GO:0042391 regulation of membrane potential
20.12 2.24e-02 GO:0051899 membrane depolarization
4.24 2.61e-02 GO:0006812 cation transport
11.84 3.19e-02 GO:0007218 neuropeptide signaling pathway
11.43 3.76e-02 GO:0001505 regulation of neurotransmitter levels
1.99 3.79e-02 GO:0007165 signal transduction
1.50 3.81e-02 GO:0065007 biological regulation
10.82 4.90e-02 GO:0007626 locomotory behavior

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
8.30 7.49e-09 GO:0045202 synapse
9.78 1.56e-08 GO:0044456 synapse part
10.14 4.88e-08 GO:0030659 cytoplasmic vesicle membrane
20.81 5.14e-08 GO:0008021 synaptic vesicle
9.80 7.43e-08 GO:0012506 vesicle membrane
5.60 8.22e-08 GO:0016023 cytoplasmic membrane-bounded vesicle
5.49 1.12e-07 GO:0031988 membrane-bounded vesicle
5.27 2.26e-07 GO:0031410 cytoplasmic vesicle
31.28 2.63e-07 GO:0030672 synaptic vesicle membrane
5.10 3.86e-07 GO:0031982 vesicle
8.42 4.74e-07 GO:0044433 cytoplasmic vesicle part
12.50 8.03e-07 GO:0030136 clathrin-coated vesicle
18.93 1.08e-06 GO:0030665 clathrin coated vesicle membrane
5.68 1.80e-06 GO:0030054 cell junction
10.22 5.52e-06 GO:0030135 coated vesicle
2.87 7.36e-06 GO:0044459 plasma membrane part
14.00 1.18e-05 GO:0030662 coated vesicle membrane
6.31 4.58e-05 GO:0043005 neuron projection
9.47 2.35e-04 GO:0043025 neuronal cell body
9.20 2.91e-04 GO:0044297 cell body
1.69 7.63e-04 GO:0044425 membrane part
7.74 1.04e-03 GO:0034702 ion channel complex
1.57 1.10e-03 GO:0016020 membrane
1.94 1.27e-03 GO:0005886 plasma membrane
1.92 1.80e-03 GO:0071944 cell periphery
7.50 4.83e-03 GO:0030425 dendrite
3.45 5.32e-03 GO:0042995 cell projection
35.49 9.07e-03 GO:0032589 neuron projection membrane
8.16 1.11e-02 GO:0045211 postsynaptic membrane
10.17 1.57e-02 GO:0019717 synaptosome
100.53 1.73e-02 GO:0032590 dendrite membrane
14.90 1.75e-02 GO:0034707 chloride channel complex
2.79 1.83e-02 GO:0005887 integral to plasma membrane
1.65 1.99e-02 GO:0031224 intrinsic to membrane
2.74 2.27e-02 GO:0031226 intrinsic to plasma membrane
1.64 2.93e-02 GO:0016021 integral to membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
4.08 5.07e-07 GO:0005215 transporter activity
6.34 4.90e-05 GO:0005216 ion channel activity
6.25 5.79e-05 GO:0022838 substrate-specific channel activity
6.06 8.01e-05 GO:0015267 channel activity
6.04 8.23e-05 GO:0022803 passive transmembrane transporter activity
16.76 2.00e-04 GO:0005230 extracellular ligand-gated ion channel activity
4.28 2.29e-04 GO:0015075 ion transmembrane transporter activity
6.69 3.11e-04 GO:0022836 gated channel activity
3.92 3.18e-04 GO:0022891 substrate-specific transmembrane transporter activity
38.30 4.26e-04 GO:0005184 neuropeptide hormone activity
21.40 4.66e-04 GO:0005231 excitatory extracellular ligand-gated ion channel activity
3.58 5.03e-04 GO:0022892 substrate-specific transporter activity
3.63 8.42e-04 GO:0022857 transmembrane transporter activity
12.20 1.29e-03 GO:0005179 hormone activity
46.40 4.39e-03 GO:0016594 glycine binding
9.66 4.88e-03 GO:0015276 ligand-gated ion channel activity
9.66 4.88e-03 GO:0022834 ligand-gated channel activity
100.53 1.96e-02 GO:0016933 extracellular-glycine-gated ion channel activity
100.53 1.96e-02 GO:0016934 extracellular-glycine-gated chloride channel activity
80.43 3.26e-02 GO:0022824 transmitter-gated ion channel activity
80.43 3.26e-02 GO:0022835 transmitter-gated channel activity
3.53 3.53e-02 GO:0005509 calcium ion binding
3.76 4.17e-02 GO:0008324 cation transmembrane transporter activity
5.34 4.51e-02 GO:0005261 cation channel activity
67.02 4.87e-02 GO:0005237 inhibitory extracellular ligand-gated ion channel activity
8.18 4.89e-02 GO:0043176 amine binding