Motif ID: RREB1.p2

Z-value: 3.267


Transcription factors associated with RREB1.p2:

Gene SymbolEntrez IDGene Name
RREB1 6239 ras responsive element binding protein 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
RREB1chr6_+_71088640.686.6e-31Click!


Activity profile for motif RREB1.p2.

activity profile for motif RREB1.p2


Sorted Z-values histogram for motif RREB1.p2

Sorted Z-values for motif RREB1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of RREB1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_-_54982271 66.310 NM_006741
PPP1R1A
protein phosphatase 1, regulatory (inhibitor) subunit 1A
chr1_-_204380903 63.945 NM_032833
PPP1R15B
protein phosphatase 1, regulatory subunit 15B
chr4_-_5890142 60.184 CRMP1
collapsin response mediator protein 1
chr21_+_47649066 52.879 MCM3AP-AS1
MCM3AP antisense RNA 1 (non-protein coding)
chr10_-_135150474 52.339 NM_015722
CALY
calcyon neuron-specific vesicular protein
chr4_-_5890266 50.813 NM_001313
CRMP1
collapsin response mediator protein 1
chr7_+_64498643 48.290 CCT6P3
chaperonin containing TCP1, subunit 6 (zeta) pseudogene 3
chr17_+_42385780 47.972 NM_001144825
NM_001144826
NM_006695
RUNDC3A


RUN domain containing 3A


chr11_-_125366048 47.721 NM_005103
NM_022549
FEZ1

fasciculation and elongation protein zeta 1 (zygin I)

chr19_+_3366589 47.184 NFIC
nuclear factor I/C (CCAAT-binding transcription factor)
chr19_+_35521591 45.128 NM_001037
NM_199037
SCN1B

sodium channel, voltage-gated, type I, beta

chr20_+_10199455 43.627 NM_003081
NM_130811
SNAP25

synaptosomal-associated protein, 25kDa

chrX_+_102632108 42.453 NM_014380
NGFRAP1
nerve growth factor receptor (TNFRSF16) associated protein 1
chr6_-_46459010 41.601 NM_001251974
RCAN2
regulator of calcineurin 2
chr11_-_134281725 41.469 NM_018644
NM_054025
B3GAT1

beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)

chr10_-_135150368 41.054 CALY
calcyon neuron-specific vesicular protein
chr16_+_28834407 40.199 NM_007245
NM_145714
NM_148414
NM_148415
NM_148416
ATXN2L




ataxin 2-like




chr15_+_74422920 39.916 ISLR2
immunoglobulin superfamily containing leucine-rich repeat 2
chr6_-_29595746 39.317 GABBR1
gamma-aminobutyric acid (GABA) B receptor, 1
chr16_+_28834372 38.371 ATXN2L
ataxin 2-like
chr16_+_28834565 37.745 ATXN2L
ataxin 2-like
chr21_-_47648685 37.111 LSS
lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
chr19_+_3366575 36.992 NFIC
nuclear factor I/C (CCAAT-binding transcription factor)
chr2_+_149633173 36.717


chr11_+_71791376 36.082 NM_001145307
NM_001145308
NM_001205138
NM_145309
LRTOMT



leucine rich transmembrane and 0-methyltransferase domain containing



chr12_+_79258517 36.044 SYT1
synaptotagmin I
chr1_-_156217717 35.922 NM_198406
NM_024897
PAQR6

progestin and adipoQ receptor family member VI

chr15_+_74422742 35.557 NM_020851
ISLR2
immunoglobulin superfamily containing leucine-rich repeat 2
chr16_+_28834360 35.264 ATXN2L
ataxin 2-like
chr11_-_72353435 33.337 NM_001143839
NM_001243784
PDE2A

phosphodiesterase 2A, cGMP-stimulated

chr1_+_46669005 33.018 NM_001013615
C1orf190
chromosome 1 open reading frame 190
chr14_-_21493858 33.017 NDRG2
NDRG family member 2
chr12_+_79258588 32.955 SYT1
synaptotagmin I
chr17_+_43971998 32.807 MAPT
microtubule-associated protein tau
chrX_+_102631408 32.546 NGFRAP1
nerve growth factor receptor (TNFRSF16) associated protein 1
chr6_-_29595934 30.697 NM_021903
GABBR1
gamma-aminobutyric acid (GABA) B receptor, 1
chrX_-_48693934 30.560 NM_013271
PCSK1N
proprotein convertase subtilisin/kexin type 1 inhibitor
chr14_-_21493910 30.021 NM_016250
NM_201535
NM_201536
NM_201537
NDRG2



NDRG family member 2



chr2_-_218843541 30.012 TNS1
tensin 1
chr12_-_48152860 29.582 NM_001098531
RAPGEF3
Rap guanine nucleotide exchange factor (GEF) 3
chr8_+_58906968 29.442 NM_147189
FAM110B
family with sequence similarity 110, member B
chr7_+_95401817 29.394 NM_001135556
NM_001135557
NM_004411
DYNC1I1


dynein, cytoplasmic 1, intermediate chain 1


chr19_-_47975244 29.212 NM_015063
SLC8A2
solute carrier family 8 (sodium/calcium exchanger), member 2
chrX_-_137793826 29.058 NM_004114
FGF13
fibroblast growth factor 13
chr7_-_767286 28.810 NM_001164758
NM_001164759
PRKAR1B

protein kinase, cAMP-dependent, regulatory, type I, beta

chr1_-_20812727 28.595 NM_018584
CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr19_-_47975074 28.346 SLC8A2
solute carrier family 8 (sodium/calcium exchanger), member 2
chr2_-_220173693 28.078 NM_001199764
PTPRN
protein tyrosine phosphatase, receptor type, N
chr19_+_56652689 27.995 ZNF444
zinc finger protein 444
chr19_-_49944613 27.834 NM_020309
SLC17A7
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7
chr7_-_766875 27.215 NM_001164760
PRKAR1B
protein kinase, cAMP-dependent, regulatory, type I, beta
chr15_+_64752778 27.176 ZNF609
zinc finger protein 609
chr13_-_37494370 26.911 NM_001127217
NM_005905
SMAD9

SMAD family member 9

chr17_-_1733083 26.368 NM_052928
SMYD4
SET and MYND domain containing 4
chr1_+_6845381 26.368 NM_001195563
NM_001242701
NM_015215
CAMTA1


calmodulin binding transcription activator 1


chr19_-_18314731 26.309 NM_002866
RAB3A
RAB3A, member RAS oncogene family
chr12_+_79258794 26.301 SYT1
synaptotagmin I
chr17_-_48207113 26.225 NM_174920
SAMD14
sterile alpha motif domain containing 14
chrX_+_103031433 26.017 NM_001128834
PLP1
proteolipid protein 1
chr1_+_1950745 25.831 NM_000815
GABRD
gamma-aminobutyric acid (GABA) A receptor, delta
chr12_-_16758312 25.785 NM_001243611
LMO3
LIM domain only 3 (rhombotin-like 2)
chr11_+_57365026 25.696 NM_000062
SERPING1
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
chr12_+_79258448 25.474 NM_005639
SYT1
synaptotagmin I
chr7_+_44144002 25.474 AEBP1
AE binding protein 1
chr7_+_44143945 25.275 NM_001129
AEBP1
AE binding protein 1
chrX_-_153881757 25.139 NM_020994
NM_172377
CTAG2

cancer/testis antigen 2

chr21_+_27011766 24.577 JAM2
junctional adhesion molecule 2
chr19_-_12721493 24.421 NM_020714
ZNF490
zinc finger protein 490
chrX_-_137793394 24.353 FGF13
fibroblast growth factor 13
chr11_-_73309090 24.187 NM_015159
FAM168A
family with sequence similarity 168, member A
chr16_+_56225301 24.044 GNAO1
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
chr21_+_27012067 23.991 JAM2
junctional adhesion molecule 2
chr20_+_48599511 23.982 NM_005985
SNAI1
snail homolog 1 (Drosophila)
chr19_+_35629727 23.815 NM_021902
FXYD1
FXYD domain containing ion transport regulator 1
chr20_+_34742656 23.745 NM_012156
EPB41L1
erythrocyte membrane protein band 4.1-like 1
chr14_-_60097531 23.711 NM_206852
RTN1
reticulon 1
chr3_-_106959476 23.695


chr15_-_23086290 23.596 NM_144599
NIPA1
non imprinted in Prader-Willi/Angelman syndrome 1
chr19_+_56652529 23.374 NM_001253792
NM_018337
ZNF444

zinc finger protein 444

chr1_+_163041694 23.303 NM_001113380
RGS4
regulator of G-protein signaling 4
chr7_+_97910978 23.267 NM_001159491
NM_015379
BRI3

brain protein I3

chr15_+_74421698 23.246 NM_001130136
ISLR2
immunoglobulin superfamily containing leucine-rich repeat 2
chr19_-_6502224 23.111 NM_006087
TUBB4A
tubulin, beta 4A class IVa
chr14_-_60097223 23.024 RTN1
reticulon 1
chr3_-_10547340 22.845 ATP2B2
ATPase, Ca++ transporting, plasma membrane 2
chrX_+_103031753 22.761 NM_000533
NM_199478
PLP1

proteolipid protein 1

chr1_-_149889362 22.526 NM_014849
SV2A
synaptic vesicle glycoprotein 2A
chr12_-_49392909 22.365 NM_015086
DDN
dendrin
chr14_+_65007163 22.314 NM_021979
HSPA2
heat shock 70kDa protein 2
chr17_+_77751929 22.310 NM_005189
NM_032647
CBX2

chromobox homolog 2

chrY_-_16098319 22.176 NM_181880
NM_004679
VCY1B
VCX3A
VCY
variable charge, Y-linked 1B
variable charge, X-linked 3A
variable charge, Y-linked
chr11_-_1016736 22.012 MUC6
mucin 6, oligomeric mucus/gel-forming
chrY_-_1281526 21.936 NM_001012288
NM_022148
CRLF2

cytokine receptor-like factor 2

chr7_-_143059144 21.935 NM_014690
FAM131B
family with sequence similarity 131, member B
chr3_+_238535 21.832 CHL1
cell adhesion molecule with homology to L1CAM (close homolog of L1)
chr12_+_70759974 21.784 NM_014505
KCNMB4
potassium large conductance calcium-activated channel, subfamily M, beta member 4
chr19_+_3366536 21.775 NM_001245002
NM_001245004
NM_005597
NFIC


nuclear factor I/C (CCAAT-binding transcription factor)


chr14_-_60097314 21.642 RTN1
reticulon 1
chr1_+_955536 21.488


chr8_+_94929082 21.435 NM_018444
NM_001161780
NM_001161779
NM_001161781
PDP1



pyruvate dehyrogenase phosphatase catalytic subunit 1



chr11_-_17498419 21.416 NM_000352
ABCC8
ATP-binding cassette, sub-family C (CFTR/MRP), member 8
chr6_+_7108864 21.353 RREB1
ras responsive element binding protein 1
chr17_+_43972014 21.316 MAPT
microtubule-associated protein tau
chr3_+_58223228 21.291 NM_020676
ABHD6
abhydrolase domain containing 6
chr22_-_44258210 21.226 NM_014351
SULT4A1
sulfotransferase family 4A, member 1
chrX_+_38420690 21.201 NM_004615
TSPAN7
tetraspanin 7
chr21_+_27012045 21.091 JAM2
junctional adhesion molecule 2
chr12_-_53448167 21.040 LOC283335
uncharacterized LOC283335
chr5_+_175792444 21.009 NM_173664
ARL10
ADP-ribosylation factor-like 10
chr19_+_708766 20.763 NM_001040134
NM_002579
PALM

paralemmin

chr14_+_29236171 20.678 NM_005249
FOXG1
forkhead box G1
chr19_-_55866063 20.656 NM_144613
COX6B2
cytochrome c oxidase subunit VIb polypeptide 2 (testis)
chr3_-_10547267 20.641 NM_001001331
NM_001683
ATP2B2

ATPase, Ca++ transporting, plasma membrane 2

chr9_-_101470836 20.541 NM_005458
GABBR2
gamma-aminobutyric acid (GABA) B receptor, 2
chr17_+_7554711 20.390 ATP1B2
ATPase, Na+/K+ transporting, beta 2 polypeptide
chr13_+_45915479 20.329 LOC100190939
uncharacterized LOC100190939
chr9_+_132427919 20.274 NM_016307
PRRX2
paired related homeobox 2
chr14_-_21493122 20.163 NM_201538
NM_201539
NM_201540
NM_201541
NDRG2



NDRG family member 2



chr5_-_132298973 20.156 AFF4
AF4/FMR2 family, member 4
chr11_+_57365577 20.133 NM_001032295
SERPING1
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
chr19_+_35634153 20.128 NM_022006
FXYD7
FXYD domain containing ion transport regulator 7
chr14_+_100438095 19.980 EVL
Enah/Vasp-like
chrX_-_135333519 19.902 NM_001173517
NM_024597
MAP7D3

MAP7 domain containing 3

chr22_+_51039178 19.879 MAPK8IP2
mitogen-activated protein kinase 8 interacting protein 2
chr1_+_21835915 19.791 ALPL
alkaline phosphatase, liver/bone/kidney
chr2_+_231729623 19.734 ITM2C
integral membrane protein 2C
chr11_-_119293848 19.660 THY1
Thy-1 cell surface antigen
chr8_+_41685789 19.600


chr16_+_50186809 19.581 NM_001040284
NM_001040285
PAPD5

PAP associated domain containing 5

chr19_-_5340700 19.446 NM_002850
NM_130853
NM_130854
NM_130855
PTPRS



protein tyrosine phosphatase, receptor type, S



chr18_-_29522988 19.361 TRAPPC8
trafficking protein particle complex 8
chrY_+_16168097 19.337 NM_181880
NM_004679
VCY1B
VCX3A
VCY
variable charge, Y-linked 1B
variable charge, X-linked 3A
variable charge, Y-linked
chr7_+_65338161 19.229 NM_173517
VKORC1L1
vitamin K epoxide reductase complex, subunit 1-like 1
chr12_-_48152180 19.213 NM_001098532
NM_006105
RAPGEF3

Rap guanine nucleotide exchange factor (GEF) 3

chr2_-_128432642 19.184 NM_001136037
NM_001161403
LIMS2

LIM and senescent cell antigen-like domains 2

chr15_-_88799961 19.086 NM_001007156
NM_001012338
NM_001243101
NM_002530
NTRK3



neurotrophic tyrosine kinase, receptor, type 3



chr17_-_79139871 18.890 NM_001080395
AATK
apoptosis-associated tyrosine kinase
chr11_-_113746205 18.832 NM_020886
USP28
ubiquitin specific peptidase 28
chr12_+_123717843 18.790 NM_152269
NM_001194995
C12orf65

chromosome 12 open reading frame 65

chrX_-_151306959 18.776 NM_001204811
NM_001011543
NM_001251828
NM_021048
MAGEA10-MAGEA5
MAGEA10


MAGEA10-MAGEA5 readthrough
melanoma antigen family A, 10


chr3_-_42003460 18.765 NM_017886
ULK4
unc-51-like kinase 4 (C. elegans)
chr2_+_231729501 18.709 NM_001012514
NM_001012516
NM_030926
ITM2C


integral membrane protein 2C


chr10_+_134145597 18.692 NM_001143758
NM_001143759
NM_030626
LRRC27


leucine rich repeat containing 27


chr17_-_27278324 18.648 PHF12
PHD finger protein 12
chr10_-_69835042 18.541 NM_015601
NM_022079
HERC4

hect domain and RLD 4

chr5_-_142065586 18.252 NM_000800
FGF1
fibroblast growth factor 1 (acidic)
chr16_+_67198678 18.066 HSF4
heat shock transcription factor 4
chr2_-_220174058 18.040 PTPRN
protein tyrosine phosphatase, receptor type, N
chr16_+_67198637 18.028 HSF4
heat shock transcription factor 4
chr21_-_47648672 18.008 LSS
lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
chr10_+_21823573 17.965 NM_001195626
MLLT10
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
chr8_+_104152876 17.858 NM_001024372
NM_024812
BAALC

brain and acute leukemia, cytoplasmic

chr7_-_158380360 17.847 NM_002847
NM_130842
NM_130843
PTPRN2


protein tyrosine phosphatase, receptor type, N polypeptide 2


chr16_-_4588379 17.716 NM_001199054
C16orf5
chromosome 16 open reading frame 5
chr22_+_51039100 17.662 NM_012324
MAPK8IP2
mitogen-activated protein kinase 8 interacting protein 2
chr14_+_96505566 17.652 NM_001252507
C14orf132
chromosome 14 open reading frame 132
chrX_+_101906293 17.631 NM_001099410
NM_001099411
NM_014710
NM_001184727
GPRASP1



G protein-coupled receptor associated sorting protein 1



chrX_-_1331526 17.533 NM_001012288
NM_022148
CRLF2

cytokine receptor-like factor 2

chr2_-_145274916 17.439 ZEB2
zinc finger E-box binding homeobox 2
chr9_+_130374466 17.391 NM_001032221
NM_003165
STXBP1

syntaxin binding protein 1

chrX_+_135229536 17.381 NM_001159702
NM_001159703
NM_001449
FHL1


four and a half LIM domains 1


chr12_+_6930689 17.325 NM_014449
NM_019858
GPR162

G protein-coupled receptor 162

chr16_+_2039945 17.300 NM_004209
SYNGR3
synaptogyrin 3
chrX_+_152224862 17.142 PNMA3
paraneoplastic antigen MA3
chr14_+_92789536 17.047 NM_153647
SLC24A4
solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
chr19_-_36246411 17.024 HSPB6
heat shock protein, alpha-crystallin-related, B6
chr9_+_139560243 16.967 EGFL7
EGF-like-domain, multiple 7
chr1_+_33352071 16.866 NM_002143
HPCA
hippocalcin
chr12_-_49504612 16.862 LMBR1L
limb region 1 homolog (mouse)-like
chr5_-_136834887 16.771 NM_004598
SPOCK1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
chr21_-_47648715 16.741 NM_001001438
NM_001145436
NM_001145437
NM_002340
LSS



lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)



chr16_-_3285069 16.737 NM_001145447
NM_003454
ZNF200

zinc finger protein 200

chr19_-_6720585 16.713 NM_000064
C3
complement component 3
chr2_+_48757063 16.624 NM_001198593
STON1-GTF2A1L
STON1-GTF2A1L readthrough
chr11_+_119077021 16.597 CBL
Cas-Br-M (murine) ecotropic retroviral transforming sequence
chr1_+_3388170 16.568 ARHGEF16
Rho guanine nucleotide exchange factor (GEF) 16
chr8_-_22550708 16.563 NM_004430
EGR3
early growth response 3
chr3_-_52001388 16.535 NM_020418
NM_001174100
NM_033008
PCBP4


poly(rC) binding protein 4


chr16_+_50099907 16.516 HEATR3
HEAT repeat containing 3
chr16_-_71842539 16.497 AP1G1
adaptor-related protein complex 1, gamma 1 subunit
chr2_+_26915390 16.314 NM_002246
KCNK3
potassium channel, subfamily K, member 3
chr14_+_94640648 16.195 NM_020958
NM_058237
PPP4R4

protein phosphatase 4, regulatory subunit 4

chr11_+_45907198 16.160 MAPK8IP1
mitogen-activated protein kinase 8 interacting protein 1
chr21_-_47648618 16.154 LSS
lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
chr22_+_24373107 16.101 NM_001144931
LOC391322
D-dopachrome tautomerase-like
chr10_-_104178569 16.075 PSD
pleckstrin and Sec7 domain containing
chr19_-_38800508 16.074 NM_033557
YIF1B
Yip1 interacting factor homolog B (S. cerevisiae)
chr16_-_28303366 16.005


chr10_-_69835012 15.906 HERC4
hect domain and RLD 4
chr3_+_49449753 15.869 TCTA
T-cell leukemia translocation altered gene
chr12_+_4918341 15.841 NM_002235
KCNA6
potassium voltage-gated channel, shaker-related subfamily, member 6
chr2_-_220174201 15.836 NM_001199763
NM_002846
PTPRN

protein tyrosine phosphatase, receptor type, N

chr17_+_29718777 15.797 RAB11FIP4
RAB11 family interacting protein 4 (class II)
chr13_-_41240607 15.741 NM_002015
FOXO1
forkhead box O1
chr5_-_77590466 15.695 AP3B1
adaptor-related protein complex 3, beta 1 subunit
chr15_+_68871285 15.630 NM_006091
CORO2B
coronin, actin binding protein, 2B
chr2_+_231729638 15.592 ITM2C
integral membrane protein 2C
chr6_-_167275997 15.486 RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr1_-_226111977 15.439 PYCR2
pyrroline-5-carboxylate reductase family, member 2
chr14_-_101034261 15.431 NM_001159531
BEGAIN
brain-enriched guanylate kinase-associated homolog (rat)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.51 3.50e-35 GO:0048856 anatomical structure development
1.45 2.15e-34 GO:0032502 developmental process
1.47 1.60e-33 GO:0007275 multicellular organismal development
1.25 3.15e-33 GO:0065007 biological regulation
1.53 3.54e-33 GO:0048731 system development
1.76 1.54e-31 GO:0007399 nervous system development
1.56 6.30e-26 GO:0048869 cellular developmental process
1.57 1.26e-25 GO:0030154 cell differentiation
1.23 5.50e-25 GO:0050789 regulation of biological process
1.24 2.51e-24 GO:0050794 regulation of cellular process
1.29 2.92e-23 GO:0032501 multicellular organismal process
1.55 7.74e-22 GO:0048513 organ development
1.62 4.98e-21 GO:0009653 anatomical structure morphogenesis
1.34 1.10e-19 GO:0023052 signaling
1.79 1.12e-19 GO:0048468 cell development
1.78 3.37e-19 GO:0022008 neurogenesis
1.90 6.75e-19 GO:0030182 neuron differentiation
1.80 7.21e-19 GO:0048699 generation of neurons
2.08 1.49e-18 GO:0019226 transmission of nerve impulse
2.08 1.49e-18 GO:0035637 multicellular organismal signaling
1.83 9.50e-18 GO:0007267 cell-cell signaling
1.71 1.26e-17 GO:0007154 cell communication
1.12 2.03e-17 GO:0009987 cellular process
2.01 1.15e-16 GO:0007417 central nervous system development
2.08 3.58e-16 GO:0007268 synaptic transmission
1.44 8.64e-16 GO:0048523 negative regulation of cellular process
1.58 1.66e-15 GO:0051239 regulation of multicellular organismal process
1.88 5.07e-15 GO:0009887 organ morphogenesis
1.40 7.01e-15 GO:0048519 negative regulation of biological process
1.69 1.61e-14 GO:0050793 regulation of developmental process
1.78 1.43e-13 GO:0045595 regulation of cell differentiation
1.28 3.90e-13 GO:0019222 regulation of metabolic process
1.82 2.91e-12 GO:0048666 neuron development
2.04 4.15e-12 GO:0007420 brain development
1.60 4.80e-12 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.34 5.79e-12 GO:0048518 positive regulation of biological process
1.34 8.42e-12 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.69 1.45e-11 GO:2000026 regulation of multicellular organismal development
1.73 1.59e-11 GO:0010628 positive regulation of gene expression
1.37 2.77e-11 GO:0065008 regulation of biological quality
1.27 7.85e-11 GO:0080090 regulation of primary metabolic process
1.27 9.31e-11 GO:0031323 regulation of cellular metabolic process
1.32 1.10e-10 GO:0031326 regulation of cellular biosynthetic process
1.28 1.14e-10 GO:0007165 signal transduction
1.36 1.22e-10 GO:0006355 regulation of transcription, DNA-dependent
1.32 1.25e-10 GO:0009889 regulation of biosynthetic process
1.57 1.36e-10 GO:0032879 regulation of localization
1.79 1.59e-10 GO:0045892 negative regulation of transcription, DNA-dependent
1.31 1.93e-10 GO:0051171 regulation of nitrogen compound metabolic process
1.78 2.12e-10 GO:0051253 negative regulation of RNA metabolic process
1.82 2.17e-10 GO:0000904 cell morphogenesis involved in differentiation
1.34 2.40e-10 GO:0048522 positive regulation of cellular process
1.32 3.64e-10 GO:0010468 regulation of gene expression
1.72 1.22e-09 GO:0000902 cell morphogenesis
1.34 1.85e-09 GO:0051252 regulation of RNA metabolic process
1.26 2.17e-09 GO:0060255 regulation of macromolecule metabolic process
1.69 2.25e-09 GO:0051172 negative regulation of nitrogen compound metabolic process
1.70 2.99e-09 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.40 4.08e-09 GO:0023051 regulation of signaling
1.68 4.09e-09 GO:0032989 cellular component morphogenesis
1.56 5.88e-09 GO:0006351 transcription, DNA-dependent
1.69 6.94e-09 GO:0010629 negative regulation of gene expression
1.76 1.02e-08 GO:0031175 neuron projection development
1.64 1.28e-08 GO:0031327 negative regulation of cellular biosynthetic process
1.67 1.30e-08 GO:0045893 positive regulation of transcription, DNA-dependent
1.81 1.40e-08 GO:0048667 cell morphogenesis involved in neuron differentiation
1.55 2.19e-08 GO:0009888 tissue development
1.79 2.40e-08 GO:0048812 neuron projection morphogenesis
1.81 2.40e-08 GO:0007409 axonogenesis
1.22 2.66e-08 GO:0051716 cellular response to stimulus
2.29 3.02e-08 GO:0030900 forebrain development
1.61 4.55e-08 GO:0009890 negative regulation of biosynthetic process
1.30 5.41e-08 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.31 5.43e-08 GO:0042221 response to chemical stimulus
1.58 5.92e-08 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.62 5.98e-08 GO:0051254 positive regulation of RNA metabolic process
1.91 7.84e-08 GO:0051093 negative regulation of developmental process
1.29 9.17e-08 GO:0010556 regulation of macromolecule biosynthetic process
2.63 9.49e-08 GO:0006836 neurotransmitter transport
1.74 1.03e-07 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.63 1.12e-07 GO:0030030 cell projection organization
1.56 1.60e-07 GO:0051173 positive regulation of nitrogen compound metabolic process
1.52 2.73e-07 GO:0009891 positive regulation of biosynthetic process
1.89 3.01e-07 GO:0060284 regulation of cell development
1.52 3.65e-07 GO:0040011 locomotion
1.56 4.70e-07 GO:0010557 positive regulation of macromolecule biosynthetic process
1.34 5.13e-07 GO:0007166 cell surface receptor linked signaling pathway
1.61 5.16e-07 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.85 5.27e-07 GO:0044057 regulation of system process
1.78 5.94e-07 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.41 6.87e-07 GO:0009893 positive regulation of metabolic process
1.68 7.82e-07 GO:0048858 cell projection morphogenesis
1.59 8.51e-07 GO:0010558 negative regulation of macromolecule biosynthetic process
1.51 9.59e-07 GO:0031328 positive regulation of cellular biosynthetic process
2.39 1.11e-06 GO:0010769 regulation of cell morphogenesis involved in differentiation
2.90 1.25e-06 GO:0050770 regulation of axonogenesis
2.99 1.34e-06 GO:0007269 neurotransmitter secretion
1.67 1.48e-06 GO:0032990 cell part morphogenesis
2.37 1.57e-06 GO:0022604 regulation of cell morphogenesis
1.32 1.87e-06 GO:0048583 regulation of response to stimulus
1.91 4.05e-06 GO:0045596 negative regulation of cell differentiation
1.41 4.18e-06 GO:0010604 positive regulation of macromolecule metabolic process
1.37 4.43e-06 GO:0009966 regulation of signal transduction
2.60 4.76e-06 GO:0001505 regulation of neurotransmitter levels
1.38 5.35e-06 GO:0035556 intracellular signal transduction
1.87 5.84e-06 GO:0007423 sensory organ development
1.88 5.97e-06 GO:0051960 regulation of nervous system development
1.58 6.10e-06 GO:0048878 chemical homeostasis
2.48 6.63e-06 GO:0021700 developmental maturation
1.44 7.33e-06 GO:0009892 negative regulation of metabolic process
1.44 7.50e-06 GO:0009605 response to external stimulus
1.83 7.68e-06 GO:0022603 regulation of anatomical structure morphogenesis
1.68 7.76e-06 GO:0051094 positive regulation of developmental process
1.43 8.08e-06 GO:0010646 regulation of cell communication
2.78 9.78e-06 GO:0048638 regulation of developmental growth
1.46 1.38e-05 GO:0031324 negative regulation of cellular metabolic process
1.65 1.55e-05 GO:0072358 cardiovascular system development
1.65 1.55e-05 GO:0072359 circulatory system development
2.10 2.61e-05 GO:0006936 muscle contraction
1.43 2.81e-05 GO:0032774 RNA biosynthetic process
1.14 3.35e-05 GO:0050896 response to stimulus
1.65 5.44e-05 GO:0006873 cellular ion homeostasis
1.64 6.08e-05 GO:0055082 cellular chemical homeostasis
1.99 6.45e-05 GO:0048732 gland development
1.37 7.04e-05 GO:0031325 positive regulation of cellular metabolic process
1.62 7.26e-05 GO:0050801 ion homeostasis
2.32 8.03e-05 GO:0003001 generation of a signal involved in cell-cell signaling
2.32 8.03e-05 GO:0023061 signal release
1.42 1.57e-04 GO:0010605 negative regulation of macromolecule metabolic process
2.18 1.67e-04 GO:0030799 regulation of cyclic nucleotide metabolic process
1.84 1.72e-04 GO:0050767 regulation of neurogenesis
1.71 2.00e-04 GO:0007411 axon guidance
2.19 2.07e-04 GO:0030802 regulation of cyclic nucleotide biosynthetic process
2.19 2.07e-04 GO:0030808 regulation of nucleotide biosynthetic process
1.71 2.37e-04 GO:0045597 positive regulation of cell differentiation
2.58 2.75e-04 GO:0048469 cell maturation
1.61 3.21e-04 GO:0032583 regulation of gene-specific transcription
1.93 3.28e-04 GO:0007517 muscle organ development
1.96 3.30e-04 GO:0003012 muscle system process
2.32 3.46e-04 GO:0045761 regulation of adenylate cyclase activity
1.29 4.19e-04 GO:0003008 system process
1.48 4.28e-04 GO:0009719 response to endogenous stimulus
1.74 4.72e-04 GO:0051270 regulation of cellular component movement
1.43 4.83e-04 GO:0051128 regulation of cellular component organization
1.50 5.47e-04 GO:0009725 response to hormone stimulus
1.18 5.89e-04 GO:0051179 localization
2.28 6.65e-04 GO:0031279 regulation of cyclase activity
1.31 7.54e-04 GO:0065009 regulation of molecular function
2.04 7.66e-04 GO:0001655 urogenital system development
1.74 7.77e-04 GO:0061061 muscle structure development
2.16 1.18e-03 GO:0030817 regulation of cAMP biosynthetic process
1.87 1.20e-03 GO:0045664 regulation of neuron differentiation
2.23 1.25e-03 GO:0051339 regulation of lyase activity
1.63 1.37e-03 GO:0048598 embryonic morphogenesis
1.44 1.55e-03 GO:0051049 regulation of transport
2.14 1.58e-03 GO:0030814 regulation of cAMP metabolic process
1.52 2.17e-03 GO:0006935 chemotaxis
1.52 2.17e-03 GO:0042330 taxis
1.78 2.19e-03 GO:0032101 regulation of response to external stimulus
1.62 2.43e-03 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
1.44 3.00e-03 GO:0009790 embryo development
1.61 3.03e-03 GO:0090066 regulation of anatomical structure size
1.18 3.14e-03 GO:0016043 cellular component organization
1.97 3.30e-03 GO:0045165 cell fate commitment
3.22 3.66e-03 GO:0030516 regulation of axon extension
1.56 3.67e-03 GO:0040008 regulation of growth
1.75 4.57e-03 GO:0003002 regionalization
1.51 4.78e-03 GO:0048585 negative regulation of response to stimulus
1.95 5.26e-03 GO:0031344 regulation of cell projection organization
1.63 5.56e-03 GO:0032535 regulation of cellular component size
3.91 5.60e-03 GO:0042551 neuron maturation
1.70 5.64e-03 GO:0001568 blood vessel development
1.71 6.29e-03 GO:0008361 regulation of cell size
1.61 6.51e-03 GO:0007389 pattern specification process
1.55 7.19e-03 GO:0016477 cell migration
1.53 7.28e-03 GO:0046903 secretion
1.70 7.44e-03 GO:0030334 regulation of cell migration
1.77 8.23e-03 GO:0048514 blood vessel morphogenesis
1.40 8.80e-03 GO:0007155 cell adhesion
1.40 8.80e-03 GO:0022610 biological adhesion
2.30 9.01e-03 GO:0021953 central nervous system neuron differentiation
1.47 9.89e-03 GO:0019725 cellular homeostasis
3.43 1.00e-02 GO:0071300 cellular response to retinoic acid
1.63 1.04e-02 GO:0007610 behavior
1.36 1.22e-02 GO:0042592 homeostatic process
1.68 1.22e-02 GO:2000145 regulation of cell motility
1.88 1.26e-02 GO:0006813 potassium ion transport
2.00 1.30e-02 GO:0010975 regulation of neuron projection development
2.34 1.35e-02 GO:0010721 negative regulation of cell development
1.64 1.44e-02 GO:0001944 vasculature development
1.64 1.44e-02 GO:0040012 regulation of locomotion
2.09 1.46e-02 GO:0010720 positive regulation of cell development
1.59 1.52e-02 GO:0003006 developmental process involved in reproduction
1.95 1.67e-02 GO:0060191 regulation of lipase activity
1.39 1.73e-02 GO:0006468 protein phosphorylation
1.71 1.81e-02 GO:0051129 negative regulation of cellular component organization
1.86 1.92e-02 GO:0009952 anterior/posterior pattern formation
2.05 1.97e-02 GO:0072001 renal system development
3.30 1.98e-02 GO:0071299 cellular response to vitamin A
1.49 2.10e-02 GO:0048646 anatomical structure formation involved in morphogenesis
3.15 2.11e-02 GO:0048639 positive regulation of developmental growth
1.41 2.12e-02 GO:0007167 enzyme linked receptor protein signaling pathway
1.64 2.22e-02 GO:0055065 metal ion homeostasis
1.48 2.26e-02 GO:0030001 metal ion transport
2.22 2.32e-02 GO:0008016 regulation of heart contraction
1.35 2.38e-02 GO:0006811 ion transport
2.49 2.39e-02 GO:0040014 regulation of multicellular organism growth
1.17 2.54e-02 GO:0051234 establishment of localization
2.27 2.60e-02 GO:0033189 response to vitamin A
1.59 2.86e-02 GO:0051046 regulation of secretion
1.60 3.27e-02 GO:0048729 tissue morphogenesis
1.59 3.28e-02 GO:0006140 regulation of nucleotide metabolic process
1.97 3.34e-02 GO:0033273 response to vitamin
2.36 3.42e-02 GO:0032526 response to retinoic acid
3.93 3.57e-02 GO:0021879 forebrain neuron differentiation
3.18 3.73e-02 GO:0050771 negative regulation of axonogenesis
1.84 3.74e-02 GO:0048562 embryonic organ morphogenesis
1.44 3.86e-02 GO:0006928 cellular component movement
1.75 4.03e-02 GO:0032582 negative regulation of gene-specific transcription
2.38 4.15e-02 GO:0008277 regulation of G-protein coupled receptor protein signaling pathway
1.99 4.17e-02 GO:0043583 ear development
1.92 4.19e-02 GO:0048705 skeletal system morphogenesis
1.63 4.23e-02 GO:0006875 cellular metal ion homeostasis
1.81 4.29e-02 GO:0001654 eye development
1.48 4.35e-02 GO:0048870 cell motility
1.48 4.35e-02 GO:0051674 localization of cell
1.73 4.59e-02 GO:0003013 circulatory system process
1.73 4.59e-02 GO:0008015 blood circulation
2.52 4.94e-02 GO:0001764 neuron migration

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.47 6.97e-21 GO:0044459 plasma membrane part
1.92 5.89e-12 GO:0045202 synapse
1.49 2.46e-11 GO:0005887 integral to plasma membrane
1.48 3.53e-11 GO:0031226 intrinsic to plasma membrane
1.21 6.02e-09 GO:0005886 plasma membrane
1.21 1.32e-08 GO:0071944 cell periphery
1.62 2.71e-08 GO:0030054 cell junction
1.44 3.27e-08 GO:0000267 cell fraction
1.89 6.00e-08 GO:0044456 synapse part
2.03 1.49e-07 GO:0034702 ion channel complex
1.72 4.79e-07 GO:0043005 neuron projection
2.24 9.53e-07 GO:0034703 cation channel complex
1.71 1.94e-06 GO:0031012 extracellular matrix
1.46 2.08e-06 GO:0005626 insoluble fraction
1.46 5.06e-06 GO:0005624 membrane fraction
2.62 1.30e-05 GO:0042383 sarcolemma
2.37 7.79e-05 GO:0008076 voltage-gated potassium channel complex
2.37 7.79e-05 GO:0034705 potassium channel complex
1.68 8.98e-05 GO:0005578 proteinaceous extracellular matrix
1.97 2.61e-04 GO:0045211 postsynaptic membrane
1.42 2.72e-04 GO:0016023 cytoplasmic membrane-bounded vesicle
1.38 3.69e-04 GO:0042995 cell projection
1.41 3.80e-04 GO:0031988 membrane-bounded vesicle
3.02 8.46e-04 GO:0005581 collagen
2.14 1.05e-03 GO:0019717 synaptosome
1.32 1.47e-03 GO:0044421 extracellular region part
1.37 1.55e-03 GO:0031982 vesicle
1.38 1.61e-03 GO:0031410 cytoplasmic vesicle
1.58 2.71e-03 GO:0044433 cytoplasmic vesicle part
1.81 4.28e-03 GO:0030136 clathrin-coated vesicle
1.97 5.29e-03 GO:0044420 extracellular matrix part
1.45 2.66e-02 GO:0044463 cell projection part
1.50 2.77e-02 GO:0005625 soluble fraction
2.02 3.34e-02 GO:0030665 clathrin coated vesicle membrane
1.05 4.06e-02 GO:0005622 intracellular

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.75 4.02e-21 GO:0001071 nucleic acid binding transcription factor activity
1.75 4.02e-21 GO:0003700 sequence-specific DNA binding transcription factor activity
1.89 3.04e-19 GO:0043565 sequence-specific DNA binding
1.18 1.26e-15 GO:0005515 protein binding
1.59 3.07e-13 GO:0030528 transcription regulator activity
1.09 1.27e-12 GO:0005488 binding
1.95 5.17e-08 GO:0005261 cation channel activity
2.30 1.70e-07 GO:0022843 voltage-gated cation channel activity
2.07 1.72e-07 GO:0000975 regulatory region DNA binding
2.07 1.72e-07 GO:0001067 regulatory region nucleic acid binding
2.07 1.72e-07 GO:0044212 transcription regulatory region DNA binding
1.74 2.03e-07 GO:0022838 substrate-specific channel activity
1.74 3.20e-07 GO:0005216 ion channel activity
1.84 3.23e-07 GO:0022836 gated channel activity
1.72 3.68e-07 GO:0015267 channel activity
1.72 4.37e-07 GO:0022803 passive transmembrane transporter activity
2.03 1.19e-06 GO:0010843 promoter binding
1.27 1.52e-06 GO:0003677 DNA binding
1.47 1.65e-05 GO:0019899 enzyme binding
2.14 1.87e-05 GO:0005516 calmodulin binding
1.93 6.52e-05 GO:0005244 voltage-gated ion channel activity
1.93 6.52e-05 GO:0022832 voltage-gated channel activity
1.44 1.03e-04 GO:0015075 ion transmembrane transporter activity
1.69 1.22e-04 GO:0016563 transcription activator activity
2.80 2.54e-04 GO:0003707 steroid hormone receptor activity
2.09 2.81e-04 GO:0005267 potassium channel activity
1.47 8.36e-04 GO:0008324 cation transmembrane transporter activity
2.65 9.99e-04 GO:0004879 ligand-dependent nuclear receptor activity
2.16 1.58e-03 GO:0005249 voltage-gated potassium channel activity
1.36 1.91e-03 GO:0022891 substrate-specific transmembrane transporter activity
1.34 2.06e-03 GO:0022857 transmembrane transporter activity
1.30 2.41e-03 GO:0005215 transporter activity
2.59 2.68e-03 GO:0016247 channel regulator activity
3.30 4.95e-03 GO:0005245 voltage-gated calcium channel activity
1.31 6.79e-03 GO:0022892 substrate-specific transporter activity
1.85 9.62e-03 GO:0003714 transcription corepressor activity
1.47 1.13e-02 GO:0019904 protein domain specific binding
1.30 1.42e-02 GO:0005102 receptor binding
3.06 1.68e-02 GO:0017046 peptide hormone binding
1.38 1.73e-02 GO:0046983 protein dimerization activity
1.46 1.84e-02 GO:0042803 protein homodimerization activity
1.35 1.85e-02 GO:0042802 identical protein binding
1.88 2.55e-02 GO:0015276 ligand-gated ion channel activity
1.88 2.55e-02 GO:0022834 ligand-gated channel activity
1.54 2.57e-02 GO:0016564 transcription repressor activity
1.43 3.05e-02 GO:0060589 nucleoside-triphosphatase regulator activity
1.43 3.86e-02 GO:0030695 GTPase regulator activity
1.54 4.48e-02 GO:0008134 transcription factor binding