Motif ID: RXRG_dimer.p3

Z-value: 1.520


Transcription factors associated with RXRG_dimer.p3:

Gene SymbolEntrez IDGene Name
NR1H2 7376 nuclear receptor subfamily 1, group H, member 2
PPARA 5465 peroxisome proliferator-activated receptor alpha
PPARG 5468 peroxisome proliferator-activated receptor gamma
RXRA 6256 retinoid X receptor, alpha
RXRB 6257 retinoid X receptor, beta
RXRG 6258 retinoid X receptor, gamma

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
RXRBchr6_-_33168448-0.631.7e-25Click!
PPARAchr22_+_46546498-0.412.0e-10Click!
RXRGchr1_-_165414499-0.202.5e-03Click!
RXRAchr9_+_137218324-0.195.6e-03Click!
PPARGchr3_+_12329332-0.054.4e-01Click!
NR1H2chr19_+_508796810.018.3e-01Click!


Activity profile for motif RXRG_dimer.p3.

activity profile for motif RXRG_dimer.p3


Sorted Z-values histogram for motif RXRG_dimer.p3

Sorted Z-values for motif RXRG_dimer.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of RXRG_dimer.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_+_96252770 50.645 SNRPF
small nuclear ribonucleoprotein polypeptide F
chr7_-_65447233 39.587 NM_000181
GUSB
glucuronidase, beta
chr7_-_65447187 38.968 GUSB
glucuronidase, beta
chr12_+_96252705 38.861 NM_003095
SNRPF
small nuclear ribonucleoprotein polypeptide F
chr7_-_65447206 37.729 GUSB
glucuronidase, beta
chr7_-_65447162 36.059 GUSB
glucuronidase, beta
chr7_-_139763520 35.402 NM_022750
PARP12
poly (ADP-ribose) polymerase family, member 12
chr2_+_109237679 35.294 NM_001193484
LIMS1
LIM and senescent cell antigen-like domains 1
chr8_-_80942488 34.893 NM_014018
MRPS28
mitochondrial ribosomal protein S28
chr3_-_150264134 33.262 SERP1
stress-associated endoplasmic reticulum protein 1
chr3_-_113465101 32.963 NM_025146
NAA50
N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr2_-_64246431 32.858 VPS54
vacuolar protein sorting 54 homolog (S. cerevisiae)
chr7_-_72936538 32.414 BAZ1B
bromodomain adjacent to zinc finger domain, 1B
chr1_-_40042461 31.331 PABPC4
poly(A) binding protein, cytoplasmic 4 (inducible form)
chr1_-_40042519 29.517 NM_001135653
NM_001135654
NM_003819
PABPC4


poly(A) binding protein, cytoplasmic 4 (inducible form)


chr12_+_67663364 29.234 CAND1
cullin-associated and neddylation-dissociated 1
chr2_+_178257371 28.991 NM_003659
AGPS
alkylglycerone phosphate synthase
chr19_-_2328566 27.498 NM_016199
LSM7
LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr2_+_207024317 25.387 NM_001037663
NM_001959
NM_021121
EEF1B2


eukaryotic translation elongation factor 1 beta 2


chr2_+_207024614 25.152 EEF1B2
eukaryotic translation elongation factor 1 beta 2
chr2_+_178257488 23.913 AGPS
alkylglycerone phosphate synthase
chr2_-_176046120 22.856 NM_001002258
NM_001190329
NM_001689
ATP5G3


ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)


chr3_-_113464991 22.400 NAA50
N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr2_+_120125141 22.321 NM_001079863
DBI
diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
chr3_-_150264234 21.896 SERP1
stress-associated endoplasmic reticulum protein 1
chr14_-_75643335 20.361 NM_006827
TMED10
transmembrane emp24-like trafficking protein 10 (yeast)
chr2_-_198364522 20.054 HSPD1
heat shock 60kDa protein 1 (chaperonin)
chr6_-_31926628 19.681 NM_002904
RDBP
RD RNA binding protein
chr20_-_32899607 19.680 NM_001161766
AHCY
adenosylhomocysteinase
chr2_-_207024103 19.090 NM_001199981
NM_001199982
NM_001199983
NM_005006
NDUFS1



NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)



chr4_-_7069755 18.741 NM_025196
GRPEL1
GrpE-like 1, mitochondrial (E. coli)
chr7_-_74489636 18.651 WBSCR16
Williams-Beuren syndrome chromosome region 16
chr2_-_198364560 18.210 HSPD1
heat shock 60kDa protein 1 (chaperonin)
chr14_-_75643309 17.997 TMED10
transmembrane emp24-like trafficking protein 10 (yeast)
chr2_+_207024330 17.465 EEF1B2
eukaryotic translation elongation factor 1 beta 2
chr14_-_75643286 17.107 TMED10
transmembrane emp24-like trafficking protein 10 (yeast)
chr12_+_67663147 16.841 CAND1
cullin-associated and neddylation-dissociated 1
chr16_-_47007567 16.728 NM_005880
DNAJA2
DnaJ (Hsp40) homolog, subfamily A, member 2
chrX_-_153191686 16.292 ARHGAP4
Rho GTPase activating protein 4
chr14_-_75643333 16.276 TMED10
transmembrane emp24-like trafficking protein 10 (yeast)
chr1_-_43855448 16.059 MED8
mediator complex subunit 8
chr16_-_47007483 15.695 DNAJA2
DnaJ (Hsp40) homolog, subfamily A, member 2
chr19_+_10362912 15.309 MRPL4
mitochondrial ribosomal protein L4
chr2_+_109065576 14.895 NM_181453
GCC2
GRIP and coiled-coil domain containing 2
chr2_-_198364997 14.208 NM_199440
HSPD1
heat shock 60kDa protein 1 (chaperonin)
chr2_+_198365113 13.651 HSPE1
heat shock 10kDa protein 1 (chaperonin 10)
chr14_-_95623665 13.505 NM_177438
DICER1
dicer 1, ribonuclease type III
chr4_-_7069801 13.493 GRPEL1
GrpE-like 1, mitochondrial (E. coli)
chr3_-_150264280 13.355 NM_014445
SERP1
stress-associated endoplasmic reticulum protein 1
chr17_+_41150465 13.025 RPL27
ribosomal protein L27
chr1_-_40042415 12.859 PABPC4
poly(A) binding protein, cytoplasmic 4 (inducible form)
chr12_-_7079616 12.854 PHB2
prohibitin 2
chr17_+_7123246 12.616 ACADVL
acyl-CoA dehydrogenase, very long chain
chr14_-_106174914 12.589 IGHA1
immunoglobulin heavy constant alpha 1
chr7_+_143079354 12.266 ZYX
zyxin
chr2_-_198364623 12.251 NM_002156
HSPD1
heat shock 60kDa protein 1 (chaperonin)
chr17_+_41150409 11.958 NM_000988
RPL27
ribosomal protein L27
chr5_+_1801493 11.709 NM_004553
NDUFS6
NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase)
chr2_+_120124828 11.537 NM_001178017
DBI
diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
chr12_+_14538232 11.510 ATF7IP
activating transcription factor 7 interacting protein
chr12_+_67663060 11.472 NM_018448
CAND1
cullin-associated and neddylation-dissociated 1
chr22_+_30163351 11.470 NM_001003684
NM_013387
UQCR10

ubiquinol-cytochrome c reductase, complex III subunit X

chr12_-_118810712 11.319 NM_016281
TAOK3
TAO kinase 3
chr2_+_198365012 11.154 HSPE1
heat shock 10kDa protein 1 (chaperonin 10)
chrX_-_153191710 11.104 NM_001164741
NM_001666
ARHGAP4

Rho GTPase activating protein 4

chr2_+_28113598 11.085 BRE
brain and reproductive organ-expressed (TNFRSF1A modulator)
chr4_+_109541721 11.049 NM_000995
NM_033625
RPL34

ribosomal protein L34

chr7_+_143079925 10.971 ZYX
zyxin
chr22_-_24059436 10.925


chr6_+_143999058 10.925 NM_001100164
NM_001100165
PHACTR2

phosphatase and actin regulator 2

chr11_+_118230348 10.920 UBE4A
ubiquitination factor E4A
chr3_-_150264264 10.874 SERP1
stress-associated endoplasmic reticulum protein 1
chr19_+_10362886 10.810 MRPL4
mitochondrial ribosomal protein L4
chr2_+_198364720 10.682 NM_001202485
NM_002157
HSPE1-MOB4
HSPE1
HSPE1-MOB4 readthrough
heat shock 10kDa protein 1 (chaperonin 10)
chr7_-_107204705 10.588 NM_001161520
NM_006348
NM_181733
COG5


component of oligomeric golgi complex 5


chr20_+_44509847 10.516 NM_080603
ZSWIM1
zinc finger, SWIM-type containing 1
chr1_-_155881163 10.230 NM_006912
RIT1
Ras-like without CAAX 1
chr4_+_140587086 10.189 MGST2
microsomal glutathione S-transferase 2
chr20_+_30945988 9.918 NM_001164603
NM_015338
ASXL1

additional sex combs like 1 (Drosophila)

chr12_+_69004684 9.172 RAP1B
RAP1B, member of RAS oncogene family
chr6_+_31623668 9.140 NM_019101
APOM
apolipoprotein M
chrX_-_122866881 9.113 THOC2
THO complex 2
chr12_+_69004710 9.091 RAP1B
RAP1B, member of RAS oncogene family
chr7_-_74489572 9.053 WBSCR16
Williams-Beuren syndrome chromosome region 16
chrX_-_153191644 8.865 ARHGAP4
Rho GTPase activating protein 4
chr6_-_2840683 8.606 SERPINB1
serpin peptidase inhibitor, clade B (ovalbumin), member 1
chr12_+_50135953 8.157 TMBIM6
transmembrane BAX inhibitor motif containing 6
chr11_+_118230292 8.128 NM_001204077
NM_004788
UBE4A

ubiquitination factor E4A

chr1_-_6761839 8.003 DNAJC11
DnaJ (Hsp40) homolog, subfamily C, member 11
chr12_+_132413776 7.982 NM_001002019
NM_025215
PUS1

pseudouridylate synthase 1

chr7_-_74489686 7.762 NM_030798
WBSCR16
Williams-Beuren syndrome chromosome region 16
chr16_+_4714709 7.679 MGRN1
mahogunin, ring finger 1
chr3_+_37284680 7.317 NM_001172713
NM_002078
GOLGA4

golgin A4

chr1_-_226374401 7.123 NM_022735
ACBD3
acyl-CoA binding domain containing 3
chr16_+_4475804 7.042 NM_001135110
NM_005147
DNAJA3

DnaJ (Hsp40) homolog, subfamily A, member 3

chr16_+_2255708 6.898 NM_001199174
MLST8
MTOR associated protein, LST8 homolog (S. cerevisiae)
chr1_-_155881063 6.809 RIT1
Ras-like without CAAX 1
chr2_+_109065665 6.764 GCC2
GRIP and coiled-coil domain containing 2
chr11_+_118443140 6.556 ARCN1
archain 1
chr12_+_69004614 6.278 NM_001010942
NM_001251917
NM_001251918
NM_001251921
NM_001251922
NM_015646
RAP1B





RAP1B, member of RAS oncogene family





chr12_-_51422012 6.263 NM_001174125
SLC11A2
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
chr11_-_66206260 6.154 NM_016050
NM_170738
NM_170739
MRPL11


mitochondrial ribosomal protein L11


chr15_+_57210823 5.974 NM_003205
NM_207036
NM_207037
NM_207038
TCF12



transcription factor 12



chr6_+_31623688 5.921 APOM
apolipoprotein M
chr19_+_45394642 5.897 TOMM40
translocase of outer mitochondrial membrane 40 homolog (yeast)
chr1_-_40042072 5.736 PABPC4
poly(A) binding protein, cytoplasmic 4 (inducible form)
chr10_-_103815868 5.699 NM_024541
C10orf76
chromosome 10 open reading frame 76
chr6_+_33172418 5.450 NM_014234
HSD17B8
hydroxysteroid (17-beta) dehydrogenase 8
chr1_-_6761878 5.450 DNAJC11
DnaJ (Hsp40) homolog, subfamily C, member 11
chr22_+_20105076 5.336 RANBP1
RAN binding protein 1
chr11_+_86013252 5.311 NM_016401
C11orf73
chromosome 11 open reading frame 73
chrY_-_1460901 5.304 NM_001636
SLC25A6
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
chr1_-_193075186 5.158 NM_001243399
NM_016066
GLRX2

glutaredoxin 2

chr2_+_86668270 5.125 NM_018433
KDM3A
lysine (K)-specific demethylase 3A
chr12_+_132413743 5.017 NM_001002020
PUS1
pseudouridylate synthase 1
chr11_-_14386051 4.996 NM_001177314
RRAS2
related RAS viral (r-ras) oncogene homolog 2
chr2_-_24307179 4.970 NM_001206802
TP53I3
tumor protein p53 inducible protein 3
chr15_+_57210852 4.965 TCF12
transcription factor 12
chr19_+_11546938 4.923 PRKCSH
protein kinase C substrate 80K-H
chr13_+_21714709 4.890 SAP18
Sin3A-associated protein, 18kDa
chr6_-_108395939 4.773 NM_014028
OSTM1
osteopetrosis associated transmembrane protein 1
chr6_+_143771779 4.733 NM_003630
PEX3
peroxisomal biogenesis factor 3
chr7_-_25164902 4.721 NM_018947
CYCS
cytochrome c, somatic
chr1_+_154947166 4.669 CKS1B
CDC28 protein kinase regulatory subunit 1B
chr3_-_49449525 4.556 NM_001664
RHOA
ras homolog gene family, member A
chr20_-_20033005 4.414 CRNKL1
crooked neck pre-mRNA splicing factor-like 1 (Drosophila)
chr11_+_118443091 4.399 NM_001142281
NM_001655
ARCN1

archain 1

chr5_+_42548314 4.398 NM_001242403
GHR
growth hormone receptor
chr8_+_22436641 4.336 PDLIM2
PDZ and LIM domain 2 (mystique)
chr17_-_2614926 4.302 NM_015229
KIAA0664
KIAA0664
chr4_-_72671236 4.155 NM_001204306
GC
group-specific component (vitamin D binding protein)
chrX_-_122866888 3.772 NM_001081550
THOC2
THO complex 2
chr1_-_6761897 3.718 NM_018198
DNAJC11
DnaJ (Hsp40) homolog, subfamily C, member 11
chr1_+_154947147 3.662 CKS1B
CDC28 protein kinase regulatory subunit 1B
chr22_+_20105068 3.655 RANBP1
RAN binding protein 1
chr7_+_129015483 3.531 NM_001130722
AHCYL2
adenosylhomocysteinase-like 2
chr1_+_151138497 3.525 NM_001204856
NM_024041
SCNM1

sodium channel modifier 1

chr18_-_47339854 3.483 ACAA2
acetyl-CoA acyltransferase 2
chr1_+_43148359 3.411 YBX1
Y box binding protein 1
chr1_+_154947116 3.389 NM_001826
CKS1B
CDC28 protein kinase regulatory subunit 1B
chr19_+_11546485 3.329 PRKCSH
protein kinase C substrate 80K-H
chr17_+_40440481 3.147 STAT5A
signal transducer and activator of transcription 5A
chr17_+_7123149 3.144 NM_000018
NM_001033859
ACADVL

acyl-CoA dehydrogenase, very long chain

chr17_+_7812703 3.117 CHD3
chromodomain helicase DNA binding protein 3
chr15_+_57210972 3.008 TCF12
transcription factor 12
chr3_-_12881948 2.995 NM_001007074
RPL32
ribosomal protein L32
chr2_-_74756824 2.977 AUP1
ancient ubiquitous protein 1
chr22_+_20105095 2.820 RANBP1
RAN binding protein 1
chr3_-_49449393 2.814 RHOA
ras homolog gene family, member A
chr7_-_25164869 2.777 CYCS
cytochrome c, somatic
chr22_-_24059502 2.772 GUSBP11
glucuronidase, beta pseudogene 11
chr1_-_19578030 2.688 KIAA0090
KIAA0090
chrX_-_1510901 2.684 NM_001636
SLC25A6
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
chr20_-_36661822 2.669 NM_014657
TTI1
TELO2 interacting protein 1
chr15_-_82554990 2.660 EFTUD1
elongation factor Tu GTP binding domain containing 1
chr3_-_194392913 2.650 LSG1
large subunit GTPase 1 homolog (S. cerevisiae)
chr2_+_28113612 2.575 BRE
brain and reproductive organ-expressed (TNFRSF1A modulator)
chr15_-_82555076 2.507 NM_001040610
NM_024580
EFTUD1

elongation factor Tu GTP binding domain containing 1

chr19_+_54606141 2.440 NM_004542
NDUFA3
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa
chr10_+_22605300 2.320 NM_001204062
NM_012071
COMMD3-BMI1
COMMD3
COMMD3-BMI1 readthrough
COMM domain containing 3
chr6_-_108395854 2.254 OSTM1
osteopetrosis associated transmembrane protein 1
chr11_+_86748870 2.239 NM_001168724
NM_022918
TMEM135

transmembrane protein 135

chr19_+_10197023 2.176 C19orf66
chromosome 19 open reading frame 66
chr6_-_108395923 1.965 OSTM1
osteopetrosis associated transmembrane protein 1
chr22_-_19166133 1.915 SLC25A1
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
chr19_+_50016435 1.834 NM_004107
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr6_-_108395918 1.791 OSTM1
osteopetrosis associated transmembrane protein 1
chr11_+_117049838 1.790 NM_001040455
SIDT2
SID1 transmembrane family, member 2
chr5_-_74807448 1.769 NM_005713
NM_031361
COL4A3BP

collagen, type IV, alpha 3 (Goodpasture antigen) binding protein

chr22_-_19166276 1.755 SLC25A1
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
chr1_-_19578015 1.686 KIAA0090
KIAA0090
chr1_-_6420719 1.683 NM_181865
ACOT7
acyl-CoA thioesterase 7
chr18_+_29598444 1.674 NM_017831
RNF125
ring finger protein 125
chr1_+_145727665 1.645 NM_001201325
NM_001201326
NM_002614
PDZK1


PDZ domain containing 1


chr4_-_4543747 1.621 NM_016930
STX18
syntaxin 18
chr1_+_145727712 1.592 PDZK1
PDZ domain containing 1
chr1_-_32860014 1.565 NM_001143888
NM_001143889
NM_001143890
NM_018045
BSDC1



BSD domain containing 1



chr7_+_99933734 1.553 PILRB
paired immunoglobin-like type 2 receptor beta
chr19_+_45394459 1.540 NM_001128916
NM_001128917
NM_006114
TOMM40


translocase of outer mitochondrial membrane 40 homolog (yeast)


chr7_-_134855383 1.485 C7orf49
chromosome 7 open reading frame 49
chr1_-_211848820 1.460 NM_001204182
NM_001204183
NM_002497
NEK2


NIMA (never in mitosis gene a)-related kinase 2


chr19_+_10196972 1.401 C19orf66
chromosome 19 open reading frame 66
chr6_+_7107799 1.395 NM_001168344
RREB1
ras responsive element binding protein 1
chr19_+_11546085 1.387 NM_001001329
NM_002743
PRKCSH

protein kinase C substrate 80K-H

chr7_-_134855237 1.372 NM_001243752
C7orf49
chromosome 7 open reading frame 49
chr20_-_34542205 1.314 SCAND1
SCAN domain containing 1
chr12_+_49716970 1.307 NM_001100620
NM_005480
TROAP

trophinin associated protein (tastin)

chr1_-_154946801 1.295 SHC1
SHC (Src homology 2 domain containing) transforming protein 1
chr10_-_119805673 1.280 NM_014904
RAB11FIP2
RAB11 family interacting protein 2 (class I)
chr2_-_20251788 1.241 NM_014713
LAPTM4A
lysosomal protein transmembrane 4 alpha
chr3_-_194393205 1.236 NM_018385
LSG1
large subunit GTPase 1 homolog (S. cerevisiae)
chr11_-_61658853 1.192 NM_021727
FADS3
fatty acid desaturase 3
chr22_-_24059524 1.191 GUSBP11
glucuronidase, beta pseudogene 11
chr1_-_203144910 1.185 NM_004997
MYBPH
myosin binding protein H
chr12_+_6309475 1.142 NM_001769
CD9
CD9 molecule
chr4_-_4543690 1.141 STX18
syntaxin 18
chr10_+_75504119 1.094 NM_004922
NM_198597
SEC24C

SEC24 family, member C (S. cerevisiae)

chr8_+_67624652 1.035 NM_001033578
SGK3
serum/glucocorticoid regulated kinase family, member 3
chr3_-_194392881 1.030 LSG1
large subunit GTPase 1 homolog (S. cerevisiae)
chr9_+_115142395 1.020 HSDL2
hydroxysteroid dehydrogenase like 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.64 3.60e-05 GO:0044237 cellular metabolic process
1.54 2.10e-04 GO:0008152 metabolic process
1.54 2.52e-03 GO:0044238 primary metabolic process
5.86 6.60e-03 GO:0006457 protein folding
1.94 2.17e-02 GO:0009058 biosynthetic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.83 9.01e-10 GO:0044444 cytoplasmic part
3.25 3.04e-08 GO:0005739 mitochondrion
1.54 1.10e-07 GO:0005737 cytoplasm
3.70 3.77e-05 GO:0044429 mitochondrial part
1.30 4.95e-05 GO:0044424 intracellular part
1.27 1.40e-04 GO:0005622 intracellular
4.07 3.35e-04 GO:0005740 mitochondrial envelope
4.89 4.48e-04 GO:0005743 mitochondrial inner membrane
3.99 9.09e-04 GO:0031966 mitochondrial membrane
1.57 9.61e-04 GO:0044446 intracellular organelle part
1.37 9.91e-04 GO:0043231 intracellular membrane-bounded organelle
1.37 1.05e-03 GO:0043227 membrane-bounded organelle
4.48 1.15e-03 GO:0019866 organelle inner membrane
2.11 1.22e-03 GO:0031090 organelle membrane
1.55 1.68e-03 GO:0044422 organelle part
1.29 8.63e-03 GO:0043229 intracellular organelle
1.29 9.49e-03 GO:0043226 organelle
4.48 1.36e-02 GO:0005759 mitochondrial matrix
2.85 1.61e-02 GO:0031967 organelle envelope
2.80 1.99e-02 GO:0031975 envelope
1.64 3.14e-02 GO:0032991 macromolecular complex
8.48 4.91e-02 GO:0070469 respiratory chain

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.48 2.04e-04 GO:0005515 protein binding
29.83 1.26e-03 GO:0000062 fatty-acyl-CoA binding
7.92 1.27e-03 GO:0051082 unfolded protein binding
15.12 3.00e-03 GO:0005504 fatty acid binding
9.99 2.30e-02 GO:0033293 monocarboxylic acid binding
74.56 3.84e-02 GO:0004013 adenosylhomocysteinase activity
74.56 3.84e-02 GO:0016802 trialkylsulfonium hydrolase activity