Motif ID: SMAD1..7,9.p2

Z-value: 2.997


Transcription factors associated with SMAD1..7,9.p2:

Gene SymbolEntrez IDGene Name
SMAD1 4086 SMAD family member 1
SMAD2 4087 SMAD family member 2
SMAD3 4088 SMAD family member 3
SMAD4 4089 SMAD family member 4
SMAD5 4090 SMAD family member 5
SMAD6 4091 SMAD family member 6
SMAD7 4092 SMAD family member 7
SMAD9 4093 SMAD family member 9

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SMAD9chr13_-_374943700.793.0e-47Click!
SMAD6chr15_+_669946690.681.7e-31Click!
SMAD2chr18_-_45457145-0.575.0e-20Click!
SMAD4chr18_+_48556600-0.472.1e-13Click!
SMAD1chr4_+_146403955-0.441.2e-11Click!
SMAD5chr5_+_1354685220.389.2e-09Click!
SMAD7chr18_-_464770800.252.3e-04Click!
SMAD3chr15_+_67430358-0.242.7e-04Click!


Activity profile for motif SMAD1..7,9.p2.

activity profile for motif SMAD1..7,9.p2


Sorted Z-values histogram for motif SMAD1..7,9.p2

Sorted Z-values for motif SMAD1..7,9.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SMAD1..7,9.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_+_139871954 70.687 NM_000954
PTGDS
prostaglandin D2 synthase 21kDa (brain)
chr1_+_55464605 67.312 NM_057176
BSND
Bartter syndrome, infantile, with sensorineural deafness (Barttin)
chr9_+_139872014 54.535 PTGDS
prostaglandin D2 synthase 21kDa (brain)
chrX_-_70288155 45.006 NM_013346
SNX12
sorting nexin 12
chrX_-_106960028 41.185 TSC22D3
TSC22 domain family, member 3
chr5_-_58334936 37.968 NM_001197221
NM_001197222
PDE4D

phosphodiesterase 4D, cAMP-specific

chr9_+_124086842 36.532 GSN
gelsolin
chr3_-_195306274 35.699 APOD
apolipoprotein D
chr11_-_125366048 34.400 NM_005103
NM_022549
FEZ1

fasciculation and elongation protein zeta 1 (zygin I)

chr20_+_58515408 33.704 NM_001190827
NM_022106
C20orf177

chromosome 20 open reading frame 177

chrX_+_110339374 33.680 NM_002578
PAK3
p21 protein (Cdc42/Rac)-activated kinase 3
chr2_+_17721806 33.146 NM_003385
VSNL1
visinin-like 1
chr20_+_10199455 33.125 NM_003081
NM_130811
SNAP25

synaptosomal-associated protein, 25kDa

chr12_+_53443834 32.590 NM_170754
TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr9_-_97402530 32.287 NM_001127628
FBP1
fructose-1,6-bisphosphatase 1
chr16_-_4466595 31.224 CORO7
coronin 7
chr21_+_41239346 29.187 NM_006198
PCP4
Purkinje cell protein 4
chr14_-_93651242 28.790 NM_022151
MOAP1
modulator of apoptosis 1
chr11_-_60719116 28.714 NM_016582
SLC15A3
solute carrier family 15, member 3
chr12_+_112451229 28.675


chr1_+_228645807 28.572 NM_175055
HIST3H2BB
histone cluster 3, H2bb
chr6_+_31949800 28.207 NM_001242823
NM_001252204
NM_007293
NM_001002029
LOC100293534
C4A

C4B
complement C4-B-like
complement component 4A (Rodgers blood group)

complement component 4B (Chido blood group)
chr3_+_133465250 28.058 TF
transferrin
chr19_+_39897457 27.786 NM_003407
ZFP36
zinc finger protein 36, C3H type, homolog (mouse)
chr9_+_123963728 27.658 GSN
gelsolin
chr16_-_46865039 27.045 NM_001001436
C16orf87
chromosome 16 open reading frame 87
chr11_+_124609775 26.813 NM_001126181
NM_006176
NRGN

neurogranin (protein kinase C substrate, RC3)

chr2_+_17721983 26.712 VSNL1
visinin-like 1
chr16_-_3306586 26.435 NM_000243
NM_001198536
MEFV

Mediterranean fever

chr6_-_32163890 26.420 NOTCH4
notch 4
chr22_+_24891114 26.243 NM_016327
UPB1
ureidopropionase, beta
chr3_+_133465098 26.228 TF
transferrin
chr3_+_133464883 26.172 NM_001063
TF
transferrin
chrX_-_106959597 25.991 NM_001015881
TSC22D3
TSC22 domain family, member 3
chr3_+_133465204 25.868 TF
transferrin
chr14_-_106092256 25.829 IGHG4
immunoglobulin heavy constant gamma 4 (G4m marker)
chr12_+_57610577 25.732 NM_007224
NXPH4
neurexophilin 4
chr9_-_110251754 25.427 KLF4
Kruppel-like factor 4 (gut)
chr9_-_97402556 25.265 FBP1
fructose-1,6-bisphosphatase 1
chr1_+_184356227 25.154 C1orf21
chromosome 1 open reading frame 21
chr5_+_40909617 25.060 C7
complement component 7
chr11_-_117747331 24.775 FXYD6
FXYD domain containing ion transport regulator 6
chr2_+_149632836 24.656 KIF5C
kinesin family member 5C
chr3_-_39322763 24.448 NM_001171171
CX3CR1
chemokine (C-X3-C motif) receptor 1
chr4_-_174320616 24.049 NM_007281
SCRG1
stimulator of chondrogenesis 1
chr1_-_36022938 23.738 KIAA0319L
KIAA0319-like
chr9_+_124048869 23.287 GSN
gelsolin
chr5_-_149535309 23.253 PDGFRB
platelet-derived growth factor receptor, beta polypeptide
chr19_-_58326280 22.998 NM_024762
ZNF552
zinc finger protein 552
chr14_-_93651182 22.957 MOAP1
modulator of apoptosis 1
chr12_-_112450914 22.837 NM_001193453
NM_001193531
NM_138341
LOC728543
TMEM116


uncharacterized LOC728543
transmembrane protein 116


chr5_+_87564840 22.604 LOC100505894
uncharacterized LOC100505894
chr11_+_124609841 22.444 NRGN
neurogranin (protein kinase C substrate, RC3)
chr11_+_113931228 22.399 NM_001018011
ZBTB16
zinc finger and BTB domain containing 16
chrX_-_13062720 22.072 NM_174901
FAM9C
family with sequence similarity 9, member C
chr5_+_40909558 21.794 NM_000587
C7
complement component 7
chr9_+_124043719 21.657 GSN
gelsolin
chr3_-_50349811 21.514 NM_153281
HYAL1
hyaluronoglucosaminidase 1
chr5_-_151066492 21.291 NM_003118
SPARC
secreted protein, acidic, cysteine-rich (osteonectin)
chr6_-_31514393 21.154 ATP6V1G2
ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
chr3_+_111717585 21.150 NM_001008272
NM_013259
TAGLN3

transgelin 3

chr4_+_187112936 21.118 CYP4V2
cytochrome P450, family 4, subfamily V, polypeptide 2
chr17_+_12692779 21.094 NM_014859
ARHGAP44
Rho GTPase activating protein 44
chr1_+_26644458 21.035 CD52
CD52 molecule
chr15_-_83953465 20.945 NM_001717
BNC1
basonuclin 1
chr9_-_97401746 20.815 FBP1
fructose-1,6-bisphosphatase 1
chr21_-_47878592 20.716


chr1_+_22351984 20.602 LINC00339
long intergenic non-protein coding RNA 339
chr6_+_41040713 20.256 NFYA
nuclear transcription factor Y, alpha
chr1_-_11714396 20.015 FBXO2
F-box protein 2
chr22_-_29711650 19.899 NM_001007279
NM_006477
RASL10A

RAS-like, family 10, member A

chrX_-_106960268 19.873 NM_004089
TSC22D3
TSC22 domain family, member 3
chr3_+_10068123 19.826 FANCD2
Fanconi anemia, complementation group D2
chr16_-_4466607 19.800 CORO7
coronin 7
chr2_+_149632772 19.744 NM_004522
KIF5C
kinesin family member 5C
chr1_+_26644380 19.733 NM_001803
CD52
CD52 molecule
chr8_-_134309448 19.651 NM_001135242
NM_006096
NDRG1

N-myc downstream regulated 1

chr8_+_21915371 19.615 NM_001114135
EPB49
erythrocyte membrane protein band 4.9 (dematin)
chr19_+_15783827 19.427 NM_023944
CYP4F12
cytochrome P450, family 4, subfamily F, polypeptide 12
chr6_+_44355250 19.404 NM_001253
CDC5L
CDC5 cell division cycle 5-like (S. pombe)
chr1_+_159173802 19.401 NM_002036
DARC
Duffy blood group, chemokine receptor
chrX_-_107019001 19.363 NM_198057
TSC22D3
TSC22 domain family, member 3
chr11_-_64512925 19.309 NM_153819
RASGRP2
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
chr16_+_22825481 19.285 HS3ST2
heparan sulfate (glucosamine) 3-O-sulfotransferase 2
chr1_-_155145732 19.130 NM_173852
KRTCAP2
keratinocyte associated protein 2
chr7_-_108166514 18.994 PNPLA8
patatin-like phospholipase domain containing 8
chr3_+_183967514 18.877 ECE2
endothelin converting enzyme 2
chr16_-_75498582 18.798 NM_145254
TMEM170A
transmembrane protein 170A
chr20_+_1246959 18.722 NM_014723
SNPH
syntaphilin
chr4_-_88450601 18.697 NM_001128310
NM_004684
SPARCL1

SPARC-like 1 (hevin)

chr1_-_36023005 18.393 NM_024874
KIAA0319L
KIAA0319-like
chr5_-_149535420 18.365 NM_002609
PDGFRB
platelet-derived growth factor receptor, beta polypeptide
chr3_+_183967414 18.333 NM_014693
NM_032331
ECE2

endothelin converting enzyme 2

chr2_-_211035913 18.271 NM_152519
C2orf67
chromosome 2 open reading frame 67
chr3_+_35681008 18.215 ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr7_-_44228880 18.195 NM_000162
GCK
glucokinase (hexokinase 4)
chr16_+_2198607 18.187 NM_014353
RAB26
RAB26, member RAS oncogene family
chr1_-_16345284 18.030 NM_014424
HSPB7
heat shock 27kDa protein family, member 7 (cardiovascular)
chr10_-_128077062 17.975 ADAM12
ADAM metallopeptidase domain 12
chr11_-_33890931 17.947 LMO2
LIM domain only 2 (rhombotin-like 1)
chr9_-_35111534 17.844 FAM214B
family with sequence similarity 214, member B
chr22_+_43808011 17.787 NM_001044370
MPPED1
metallophosphoesterase domain containing 1
chr1_-_11714471 17.730 FBXO2
F-box protein 2
chr8_+_142432006 17.611 NM_007079
NM_032611
PTP4A3

protein tyrosine phosphatase type IVA, member 3

chr22_-_46449972 17.458 NM_018280
C22orf26
chromosome 22 open reading frame 26
chrX_+_102000906 17.366 NM_001142529
NM_001142530
BHLHB9

basic helix-loop-helix domain containing, class B, 9

chr17_+_19437140 17.334 NM_018242
SLC47A1
solute carrier family 47, member 1
chr17_+_42385780 17.232 NM_001144825
NM_001144826
NM_006695
RUNDC3A


RUN domain containing 3A


chr22_-_17690778 17.096 NM_017424
CECR1
cat eye syndrome chromosome region, candidate 1
chr19_-_21512148 16.894 NM_021269
ZNF708
zinc finger protein 708
chr17_-_62009620 16.794 NM_000626
NM_001039933
NM_021602
CD79B


CD79b molecule, immunoglobulin-associated beta


chr21_+_44394691 16.791 PKNOX1
PBX/knotted 1 homeobox 1
chr9_-_97401833 16.694 NM_000507
FBP1
fructose-1,6-bisphosphatase 1
chr17_+_41857802 16.688 NM_001136483
C17orf105
chromosome 17 open reading frame 105
chr12_-_109458844 16.557 NM_018711
SVOP
SV2 related protein homolog (rat)
chr16_-_4466570 16.523 CORO7-PAM16
CORO7
CORO7-PAM16 readthrough
coronin 7
chrX_-_107018889 16.479 TSC22D3
TSC22 domain family, member 3
chr2_+_220283098 16.475 NM_001927
DES
desmin
chr11_-_66445318 16.387 RBM4B
RNA binding motif protein 4B
chr19_-_17414083 16.366 NM_024527
ABHD8
abhydrolase domain containing 8
chr5_+_113698304 16.332 KCNN2
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
chr6_+_41040687 16.147 NM_002505
NM_021705
NFYA

nuclear transcription factor Y, alpha

chr9_-_98079856 16.147 NM_000136
NM_001243744
FANCC

Fanconi anemia, complementation group C

chr10_+_74451838 16.135 NM_138357
MCU
mitochondrial calcium uniporter
chr16_-_4465876 16.089 CORO7
coronin 7
chr12_-_51717835 16.088 BIN2
bridging integrator 2
chr5_-_151066445 15.941 SPARC
secreted protein, acidic, cysteine-rich (osteonectin)
chr22_+_38453478 15.935 PICK1
protein interacting with PRKCA 1
chr8_-_110657745 15.917 NM_001099751
NM_001099752
SYBU

syntabulin (syntaxin-interacting)

chr14_-_24780626 15.899


chr16_-_31084822 15.877 NM_001172668
ZNF668
zinc finger protein 668
chr16_+_8806825 15.725 NM_000663
ABAT
4-aminobutyrate aminotransferase
chr19_-_47975244 15.501 NM_015063
SLC8A2
solute carrier family 8 (sodium/calcium exchanger), member 2
chr6_-_31514620 15.453 NM_001204078
NM_130463
NM_138282
ATP6V1G2


ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2


chr14_-_24780570 15.413 NM_014430
CIDEB
cell death-inducing DFFA-like effector b
chr12_-_51717941 15.402 BIN2
bridging integrator 2
chr1_-_59012379 15.346 NM_145243
OMA1
OMA1 zinc metallopeptidase homolog (S. cerevisiae)
chr14_-_107113943 15.335 IGHA1
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr11_-_124543598 15.315 NM_170601
SIAE
sialic acid acetylesterase
chr12_-_51717905 15.258 NM_016293
BIN2
bridging integrator 2
chr4_-_5828587 15.258 CRMP1
collapsin response mediator protein 1
chr17_+_18163836 15.165 NM_001144900
NM_139162
SMCR7

Smith-Magenis syndrome chromosome region, candidate 7

chr3_+_16926451 15.130 NM_001144382
PLCL2
phospholipase C-like 2
chr16_+_2198687 14.969 RAB26
RAB26, member RAS oncogene family
chr20_+_30102237 14.968 NM_030789
NM_178580
NM_178581
NM_178582
HM13



histocompatibility (minor) 13



chr9_-_130616592 14.946 ENG
endoglin
chr2_-_234475400 14.928 USP40
ubiquitin specific peptidase 40
chr20_+_30102261 14.910 HM13
histocompatibility (minor) 13
chr1_+_179712297 14.893 NM_173509
FAM163A
family with sequence similarity 163, member A
chr9_-_130616957 14.878 ENG
endoglin
chr12_+_54402795 14.870 NM_022658
HOXC8
homeobox C8
chr3_-_10067989 14.691 CIDECP
cell death-inducing DFFA-like effector c pseudogene
chr1_+_156589085 14.661 NM_021817
HAPLN2
hyaluronan and proteoglycan link protein 2
chr22_+_23229959 14.654 NM_001178126
IGLL5
IGLC1
immunoglobulin lambda-like polypeptide 5
immunoglobulin lambda constant 1 (Mcg marker)
chr11_-_33891258 14.612 LMO2
LIM domain only 2 (rhombotin-like 1)
chr15_-_77197743 14.583 SCAPER
S-phase cyclin A-associated protein in the ER
chr12_-_9360960 14.582 NM_002864
PZP
pregnancy-zone protein
chr1_+_16062808 14.530 NM_207348
SLC25A34
solute carrier family 25, member 34
chr14_-_24780641 14.502 CIDEB
cell death-inducing DFFA-like effector b
chr10_+_135480367 14.481 NM_033178
NM_012147
NM_001127387
NM_001127388
NM_001127389
NM_001164467
NM_001127386
DUX4
DUX2
DUX4L7
DUX4L6
DUX4L5
DUX4L3
DUX4L2
double homeobox 4
double homeobox 2
double homeobox 4 like 7
double homeobox 4 like 6
double homeobox 4 like 5
double homeobox 4 like 3
double homeobox 4 like 2
chrX_+_21392396 14.454 NM_001168647
NM_001168648
NM_001168649
NM_014927
CNKSR2



connector enhancer of kinase suppressor of Ras 2



chr14_+_75536298 14.438 NM_001042430
NM_024643
FAM164C

family with sequence similarity 164, member C

chr17_+_74733468 14.398 NM_001242532
NM_001242533
NM_001242535
NM_001242536
NM_001242537
NM_024311
MFSD11





major facilitator superfamily domain containing 11





chr12_+_56623819 14.384 NM_173596
SLC39A5
solute carrier family 39 (metal ion transporter), member 5
chr21_+_47878764 14.351 NM_001146114
NM_001146115
NM_001146116
NM_015151
NM_206889
NM_206890
NM_206891
DIP2A






DIP2 disco-interacting protein 2 homolog A (Drosophila)






chr1_+_205012427 14.350 CNTN2
contactin 2 (axonal)
chr11_+_313852 14.309 NM_003641
IFITM1
interferon induced transmembrane protein 1 (9-27)
chr8_-_27941387 14.268 NM_001010906
C8orf80
chromosome 8 open reading frame 80
chr19_-_51529869 14.230 NM_001136032
KLK11
kallikrein-related peptidase 11
chrX_+_128913897 14.128 SASH3
SAM and SH3 domain containing 3
chrX_-_43741593 14.123 NM_000898
MAOB
monoamine oxidase B
chr11_-_111782447 14.085 NM_001885
CRYAB
crystallin, alpha B
chr16_-_90038869 14.000 CENPBD1
CENPB DNA-binding domains containing 1
chr19_+_18942786 13.967 UPF1
UPF1 regulator of nonsense transcripts homolog (yeast)
chrX_+_128913881 13.923 NM_018990
SASH3
SAM and SH3 domain containing 3
chr19_-_58629762 13.921 NM_001145542
ZSCAN18
zinc finger and SCAN domain containing 18
chr14_-_23834417 13.883 EFS
embryonal Fyn-associated substrate
chr12_+_50355278 13.776 NM_001651
AQP5
aquaporin 5
chr22_+_38035718 13.773 SH3BP1
SH3-domain binding protein 1
chr3_-_171177851 13.769 NM_001161560
NM_001161561
NM_001161562
NM_001161563
NM_001161564
NM_001161565
NM_001161566
NM_015028
TNIK







TRAF2 and NCK interacting kinase







chr12_-_104443698 13.751 GLT8D2
glycosyltransferase 8 domain containing 2
chr9_+_126773851 13.661 NM_004789
LHX2
LIM homeobox 2
chr4_-_105412466 13.655 NM_025212
CXXC4
CXXC finger protein 4
chr22_-_29711474 13.633 RASL10A
RAS-like, family 10, member A
chr7_+_97910978 13.585 NM_001159491
NM_015379
BRI3

brain protein I3

chr12_+_53440809 13.489 NM_198316
TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr6_+_132129195 13.476 ENPP1
ectonucleotide pyrophosphatase/phosphodiesterase 1
chr16_-_325867 13.327 NM_003834
NM_183337
RGS11

regulator of G-protein signaling 11

chrX_-_50557019 13.324 NM_020717
SHROOM4
shroom family member 4
chr6_-_46922533 13.321 NM_015234
GPR116
G protein-coupled receptor 116
chr1_-_35325335 13.139 NM_001164825
NM_138428
C1orf212

chromosome 1 open reading frame 212

chr2_+_177053306 13.102 NM_024501
HOXD1
homeobox D1
chr14_+_21538339 13.090 NM_018071
ARHGEF40
Rho guanine nucleotide exchange factor (GEF) 40
chr11_-_117186918 13.076 NM_012104
NM_138971
NM_138972
NM_138973
BACE1



beta-site APP-cleaving enzyme 1



chr19_+_35773409 13.065 NM_021175
HAMP
hepcidin antimicrobial peptide
chr1_-_16563658 13.060 NM_030907
RSG1
REM2 and RAB-like small GTPase 1
chr11_+_57365577 13.058 NM_001032295
SERPING1
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
chr6_-_32551993 13.046 HLA-DRB1
HLA-DRB4
HLA-DRB5
major histocompatibility complex, class II, DR beta 1
major histocompatibility complex, class II, DR beta 4
major histocompatibility complex, class II, DR beta 5
chr3_-_39323183 12.993 NM_001171174
CX3CR1
chemokine (C-X3-C motif) receptor 1
chrX_+_54556726 12.992 GNL3L
guanine nucleotide binding protein-like 3 (nucleolar)-like

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.29 1.80e-28 GO:0065007 biological regulation
1.27 1.66e-22 GO:0050789 regulation of biological process
1.45 3.78e-22 GO:0023052 signaling
1.34 1.33e-20 GO:0032501 multicellular organismal process
1.16 2.15e-20 GO:0009987 cellular process
1.51 1.10e-19 GO:0048731 system development
1.47 4.20e-19 GO:0048856 anatomical structure development
1.44 4.41e-19 GO:0007275 multicellular organismal development
1.40 8.41e-18 GO:0032502 developmental process
1.26 8.70e-18 GO:0050794 regulation of cellular process
1.41 2.29e-15 GO:0007165 signal transduction
1.66 1.02e-14 GO:0007399 nervous system development
1.26 1.10e-14 GO:0050896 response to stimulus
1.51 1.00e-13 GO:0065008 regulation of biological quality
1.65 4.38e-12 GO:0051239 regulation of multicellular organismal process
1.31 1.01e-11 GO:0051716 cellular response to stimulus
1.47 5.67e-11 GO:0030154 cell differentiation
1.46 7.62e-11 GO:0048869 cellular developmental process
1.44 1.91e-10 GO:0042221 response to chemical stimulus
1.55 4.11e-10 GO:0009653 anatomical structure morphogenesis
1.49 8.29e-10 GO:0007166 cell surface receptor linked signaling pathway
1.73 1.25e-09 GO:0048699 generation of neurons
1.70 2.01e-09 GO:0022008 neurogenesis
1.77 3.53e-09 GO:0007267 cell-cell signaling
1.71 6.32e-09 GO:0040011 locomotion
1.45 1.25e-08 GO:0048513 organ development
1.65 6.01e-08 GO:0048468 cell development
1.62 6.13e-08 GO:0007154 cell communication
1.75 8.24e-08 GO:0030182 neuron differentiation
1.81 2.98e-07 GO:0048666 neuron development
1.86 3.32e-07 GO:0006935 chemotaxis
1.86 3.32e-07 GO:0042330 taxis
1.63 3.46e-07 GO:0009611 response to wounding
1.59 4.20e-07 GO:0009605 response to external stimulus
1.26 6.73e-07 GO:0019222 regulation of metabolic process
1.61 1.26e-06 GO:0050793 regulation of developmental process
1.35 1.98e-06 GO:0048519 negative regulation of biological process
1.89 2.00e-06 GO:0048667 cell morphogenesis involved in neuron differentiation
1.86 2.02e-06 GO:0050801 ion homeostasis
1.74 2.10e-06 GO:0048878 chemical homeostasis
1.88 2.38e-06 GO:0048812 neuron projection morphogenesis
1.34 2.44e-06 GO:0006950 response to stress
1.89 2.56e-06 GO:0006873 cellular ion homeostasis
1.83 2.80e-06 GO:0019226 transmission of nerve impulse
1.83 2.80e-06 GO:0031175 neuron projection development
1.83 2.80e-06 GO:0035637 multicellular organismal signaling
1.82 2.88e-06 GO:0032990 cell part morphogenesis
1.90 3.16e-06 GO:0007409 axonogenesis
1.82 3.67e-06 GO:0048858 cell projection morphogenesis
1.49 4.28e-06 GO:0002376 immune system process
1.71 5.86e-06 GO:0032989 cellular component morphogenesis
1.73 6.88e-06 GO:0000902 cell morphogenesis
1.85 7.84e-06 GO:0055082 cellular chemical homeostasis
1.38 1.06e-05 GO:0048583 regulation of response to stimulus
1.79 1.12e-05 GO:0000904 cell morphogenesis involved in differentiation
2.25 2.10e-05 GO:0072507 divalent inorganic cation homeostasis
1.96 2.12e-05 GO:0007411 axon guidance
1.61 3.33e-05 GO:2000026 regulation of multicellular organismal development
2.25 4.13e-05 GO:0055074 calcium ion homeostasis
2.25 4.13e-05 GO:0072503 cellular divalent inorganic cation homeostasis
1.25 4.59e-05 GO:0080090 regulation of primary metabolic process
1.52 4.69e-05 GO:0032879 regulation of localization
1.58 4.75e-05 GO:0006952 defense response
1.33 6.18e-05 GO:0048523 negative regulation of cellular process
1.68 7.21e-05 GO:0009887 organ morphogenesis
1.45 8.07e-05 GO:0010033 response to organic substance
1.79 9.52e-05 GO:0007268 synaptic transmission
1.65 9.81e-05 GO:0030030 cell projection organization
2.23 9.88e-05 GO:0006874 cellular calcium ion homeostasis
1.73 1.21e-04 GO:0001775 cell activation
2.08 1.63e-04 GO:0030168 platelet activation
1.80 1.71e-04 GO:0016477 cell migration
1.89 2.21e-04 GO:0055080 cation homeostasis
1.96 2.75e-04 GO:0055065 metal ion homeostasis
1.87 3.34e-04 GO:0044057 regulation of system process
2.48 3.47e-04 GO:0030802 regulation of cyclic nucleotide biosynthetic process
2.48 3.47e-04 GO:0030808 regulation of nucleotide biosynthetic process
1.23 3.84e-04 GO:0051179 localization
4.46 4.02e-04 GO:0048483 autonomic nervous system development
2.53 4.13e-04 GO:0030817 regulation of cAMP biosynthetic process
1.23 4.13e-04 GO:0031323 regulation of cellular metabolic process
2.74 4.81e-04 GO:0001505 regulation of neurotransmitter levels
1.72 4.94e-04 GO:0072358 cardiovascular system development
1.72 4.94e-04 GO:0072359 circulatory system development
1.66 5.16e-04 GO:0007186 G-protein coupled receptor protein signaling pathway
2.51 5.30e-04 GO:0030814 regulation of cAMP metabolic process
2.44 5.56e-04 GO:0001763 morphogenesis of a branching structure
2.57 6.20e-04 GO:0061138 morphogenesis of a branching epithelium
2.42 7.01e-04 GO:0030799 regulation of cyclic nucleotide metabolic process
1.65 7.01e-04 GO:0006928 cellular component movement
1.27 7.17e-04 GO:0009889 regulation of biosynthetic process
1.27 7.86e-04 GO:0031326 regulation of cellular biosynthetic process
3.06 8.13e-04 GO:0007269 neurotransmitter secretion
1.38 8.97e-04 GO:0065009 regulation of molecular function
1.94 9.03e-04 GO:0006875 cellular metal ion homeostasis
1.39 9.71e-04 GO:0035556 intracellular signal transduction
1.52 9.86e-04 GO:0048584 positive regulation of response to stimulus
1.57 1.00e-03 GO:0045595 regulation of cell differentiation
1.26 1.09e-03 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.64 1.10e-03 GO:0019725 cellular homeostasis
2.59 1.20e-03 GO:0045761 regulation of adenylate cyclase activity
2.50 1.32e-03 GO:0007204 elevation of cytosolic calcium ion concentration
1.87 1.40e-03 GO:0030003 cellular cation homeostasis
1.61 1.53e-03 GO:0042060 wound healing
1.69 1.73e-03 GO:0048870 cell motility
1.69 1.73e-03 GO:0051674 localization of cell
1.85 1.89e-03 GO:0006140 regulation of nucleotide metabolic process
2.54 2.00e-03 GO:0031279 regulation of cyclase activity
1.63 2.05e-03 GO:0051336 regulation of hydrolase activity
1.86 2.05e-03 GO:0019932 second-messenger-mediated signaling
1.34 2.14e-03 GO:0023051 regulation of signaling
3.39 2.30e-03 GO:0007422 peripheral nervous system development
1.83 2.50e-03 GO:0001501 skeletal system development
2.36 2.70e-03 GO:0051480 cytosolic calcium ion homeostasis
1.60 2.76e-03 GO:0050878 regulation of body fluid levels
1.54 2.86e-03 GO:0009790 embryo development
1.56 3.02e-03 GO:0007167 enzyme linked receptor protein signaling pathway
1.63 3.12e-03 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
2.49 3.27e-03 GO:0051339 regulation of lyase activity
1.45 3.89e-03 GO:0042127 regulation of cell proliferation
1.25 3.94e-03 GO:0051171 regulation of nitrogen compound metabolic process
1.25 4.26e-03 GO:0048518 positive regulation of biological process
1.64 4.52e-03 GO:0007599 hemostasis
1.81 4.61e-03 GO:0007610 behavior
1.46 5.10e-03 GO:0006811 ion transport
1.47 5.33e-03 GO:0009888 tissue development
5.36 5.63e-03 GO:0048484 enteric nervous system development
1.48 6.07e-03 GO:0055085 transmembrane transport
2.01 7.20e-03 GO:0003013 circulatory system process
2.01 7.20e-03 GO:0008015 blood circulation
1.65 8.99e-03 GO:0051094 positive regulation of developmental process
1.60 1.08e-02 GO:0007417 central nervous system development
1.61 1.15e-02 GO:0007596 blood coagulation
1.61 1.15e-02 GO:0050817 coagulation
1.21 1.43e-02 GO:0060255 regulation of macromolecule metabolic process
2.36 1.64e-02 GO:0006836 neurotransmitter transport
1.48 1.83e-02 GO:0006955 immune response
1.44 1.92e-02 GO:0042592 homeostatic process
1.64 1.95e-02 GO:0032583 regulation of gene-specific transcription
1.44 2.03e-02 GO:0009891 positive regulation of biosynthetic process
1.80 2.19e-02 GO:0051960 regulation of nervous system development
1.76 2.24e-02 GO:0034097 response to cytokine stimulus
1.47 2.29e-02 GO:0007155 cell adhesion
1.47 2.29e-02 GO:0022610 biological adhesion
1.37 2.48e-02 GO:0050790 regulation of catalytic activity
1.81 2.75e-02 GO:0001568 blood vessel development
1.84 2.97e-02 GO:0051241 negative regulation of multicellular organismal process
2.26 3.02e-02 GO:0060193 positive regulation of lipase activity
1.63 3.11e-02 GO:0040008 regulation of growth
1.77 3.19e-02 GO:0001944 vasculature development
1.44 3.33e-02 GO:0031328 positive regulation of cellular biosynthetic process
3.73 3.95e-02 GO:0021545 cranial nerve development
3.35 4.26e-02 GO:0021675 nerve development

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.64 5.16e-25 GO:0044459 plasma membrane part
1.78 1.05e-18 GO:0005887 integral to plasma membrane
1.76 1.67e-18 GO:0031226 intrinsic to plasma membrane
1.33 8.46e-15 GO:0005886 plasma membrane
1.33 1.17e-14 GO:0071944 cell periphery
1.70 1.32e-06 GO:0030054 cell junction
1.14 8.05e-06 GO:0016020 membrane
1.78 2.83e-05 GO:0045202 synapse
1.53 3.09e-05 GO:0005626 insoluble fraction
1.47 3.14e-05 GO:0044421 extracellular region part
1.43 1.50e-04 GO:0000267 cell fraction
1.81 5.92e-04 GO:0044456 synapse part
1.47 7.50e-04 GO:0005624 membrane fraction
1.47 1.22e-03 GO:0005615 extracellular space
1.13 1.52e-03 GO:0044425 membrane part
1.66 1.92e-03 GO:0043005 neuron projection
1.67 2.55e-03 GO:0031012 extracellular matrix
1.71 5.04e-03 GO:0005578 proteinaceous extracellular matrix
1.26 5.87e-03 GO:0005576 extracellular region
1.63 7.21e-03 GO:0009986 cell surface
2.01 1.10e-02 GO:0045211 postsynaptic membrane
1.82 1.63e-02 GO:0034702 ion channel complex
1.39 1.70e-02 GO:0042995 cell projection

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.65 6.53e-10 GO:0001071 nucleic acid binding transcription factor activity
1.65 6.53e-10 GO:0003700 sequence-specific DNA binding transcription factor activity
1.76 6.92e-09 GO:0043565 sequence-specific DNA binding
1.17 3.40e-08 GO:0005515 protein binding
1.46 2.83e-04 GO:0022857 transmembrane transporter activity
1.71 4.46e-04 GO:0022803 passive transmembrane transporter activity
1.69 7.81e-04 GO:0015267 channel activity
1.42 1.57e-03 GO:0005102 receptor binding
1.07 2.05e-03 GO:0005488 binding
1.66 2.97e-03 GO:0022838 substrate-specific channel activity
1.27 3.39e-03 GO:0004871 signal transducer activity
1.27 3.39e-03 GO:0060089 molecular transducer activity
1.36 4.57e-03 GO:0005215 transporter activity
1.39 5.12e-03 GO:0030528 transcription regulator activity
1.74 5.54e-03 GO:0022836 gated channel activity
1.65 5.72e-03 GO:0005216 ion channel activity
2.08 7.24e-03 GO:0005539 glycosaminoglycan binding
1.41 8.57e-03 GO:0022891 substrate-specific transmembrane transporter activity
3.21 1.01e-02 GO:0003823 antigen binding
1.45 1.06e-02 GO:0015075 ion transmembrane transporter activity
2.23 1.42e-02 GO:0019955 cytokine binding
2.07 1.80e-02 GO:0004713 protein tyrosine kinase activity
1.56 1.84e-02 GO:0030695 GTPase regulator activity
1.97 2.07e-02 GO:0001871 pattern binding
1.97 2.07e-02 GO:0030247 polysaccharide binding
1.36 2.66e-02 GO:0022892 substrate-specific transporter activity
1.36 4.48e-02 GO:0030234 enzyme regulator activity