Motif ID: SPIB.p2

Z-value: 2.637


Transcription factors associated with SPIB.p2:

Gene SymbolEntrez IDGene Name
SPIB 6689 Spi-B transcription factor (Spi-1/PU.1 related)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SPIBchr19_+_509221940.186.2e-03Click!


Activity profile for motif SPIB.p2.

activity profile for motif SPIB.p2


Sorted Z-values histogram for motif SPIB.p2

Sorted Z-values for motif SPIB.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SPIB.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_-_15114495 107.151 NM_001175
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chrX_+_48542159 60.204 NM_000377
WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr19_+_49838673 42.039 NM_001040031
NM_001774
CD37

CD37 molecule

chr19_+_49838700 41.913 CD37
CD37 molecule
chr19_-_41859253 41.857 TGFB1
transforming growth factor, beta 1
chr19_+_49838646 40.151 CD37
CD37 molecule
chr6_+_31553955 37.698 NM_205838
NM_205839
LST1

leukocyte specific transcript 1

chr6_-_32160289 35.723 GPSM3
G-protein signaling modulator 3
chr3_-_121379757 34.369 NM_005335
HCLS1
hematopoietic cell-specific Lyn substrate 1
chr16_+_30194925 33.401 CORO1A
coronin, actin binding protein, 1A
chr19_+_49838734 32.469 CD37
CD37 molecule
chr1_-_183560010 32.250 NM_001127651
NCF2
neutrophil cytosolic factor 2
chr3_-_121379701 31.390 HCLS1
hematopoietic cell-specific Lyn substrate 1
chr11_-_58343308 31.120 NM_004811
LPXN
leupaxin
chr1_-_183559669 29.665 NM_000433
NM_001190789
NM_001190794
NCF2


neutrophil cytosolic factor 2


chr19_-_41859519 29.264 TGFB1
transforming growth factor, beta 1
chr2_-_175499275 28.722 NM_003387
WIPF1
WAS/WASL interacting protein family, member 1
chr5_+_169064274 28.235 DOCK2
dedicator of cytokinesis 2
chr12_+_54891539 28.069 NCKAP1L
NCK-associated protein 1-like
chr19_-_41859332 27.978 TGFB1
transforming growth factor, beta 1
chr14_+_88471467 27.296 NM_003608
GPR65
G protein-coupled receptor 65
chr17_+_34431219 26.940 NM_002984
CCL4
chemokine (C-C motif) ligand 4
chr1_-_153518265 26.662 NM_002961
NM_019554
S100A4

S100 calcium binding protein A4

chr12_+_54891522 26.503 NCKAP1L
NCK-associated protein 1-like
chr12_+_6898605 26.441 NM_000616
NM_001195014
NM_001195015
NM_001195016
NM_001195017
CD4




CD4 molecule




chr5_-_169724782 26.148 LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr12_+_7060538 26.035 PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr12_+_54891491 25.861 NM_005337
NCKAP1L
NCK-associated protein 1-like
chr1_-_25256364 25.755 RUNX3
runt-related transcription factor 3
chr19_-_41859830 25.518 NM_000660
TGFB1
transforming growth factor, beta 1
chr12_+_25205180 25.391 NM_001204126
NM_001204127
NM_006152
LRMP


lymphoid-restricted membrane protein


chr12_+_7060517 25.385 PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr12_+_7060543 25.375 PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr12_+_7060531 25.137 PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr19_-_36233311 24.840 NM_024660
IGFLR1
IGF-like family receptor 1
chr12_+_7060554 24.459 PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr12_+_7060433 24.338 NM_002831
NM_080549
PTPN6

protein tyrosine phosphatase, non-receptor type 6

chr17_+_34640030 24.038 NM_207007
NM_001001435
CCL4L2
CCL4L1
chemokine (C-C motif) ligand 4-like 2
chemokine (C-C motif) ligand 4-like 1
chr5_-_169724817 23.822 NM_005565
LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr2_+_65454828 23.727 NM_001005386
NM_005722
ACTR2

ARP2 actin-related protein 2 homolog (yeast)

chr5_-_169724734 23.642 LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr19_+_35645614 22.610 NM_014164
FXYD5
FXYD domain containing ion transport regulator 5
chr10_+_70847857 22.480 SRGN
serglycin
chr8_-_101734290 20.965 PABPC1
poly(A) binding protein, cytoplasmic 1
chr1_-_183559463 20.691 NCF2
neutrophil cytosolic factor 2
chr14_-_35344852 20.626 NM_013448
NM_182648
BAZ1A

bromodomain adjacent to zinc finger domain, 1A

chr6_+_31554475 20.242 NM_205837
LST1
leukocyte specific transcript 1
chr10_+_70847817 20.141 NM_002727
SRGN
serglycin
chr12_+_6898705 19.485 CD4
CD4 molecule
chr14_+_100531764 19.473 EVL
Enah/Vasp-like
chr8_-_101734162 19.407 PABPC1
poly(A) binding protein, cytoplasmic 1
chr5_-_149466126 19.290 CSF1R
colony stimulating factor 1 receptor
chr8_-_101734313 18.775 NM_002568
PABPC1
poly(A) binding protein, cytoplasmic 1
chr17_+_40439564 18.534 NM_003152
STAT5A
signal transducer and activator of transcription 5A
chr17_+_34538464 18.337 NM_207007
NM_001001435
CCL4L2
CCL4L1
chemokine (C-C motif) ligand 4-like 2
chemokine (C-C motif) ligand 4-like 1
chrX_+_109246338 18.095 NM_032227
TMEM164
transmembrane protein 164
chr3_+_152017193 18.020 NM_207293
NM_207294
NM_207295
NM_207296
NM_207297
MBNL1




muscleblind-like (Drosophila)




chr8_-_134115309 17.941 NM_001045556
NM_001045557
SLA

Src-like-adaptor

chr7_+_139528951 17.869 NM_001061
NM_001166253
NM_030984
TBXAS1


thromboxane A synthase 1 (platelet)


chr5_-_169724614 17.778 LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr12_+_25205488 17.482 LRMP
lymphoid-restricted membrane protein
chr14_+_100531745 17.200 NM_016337
EVL
Enah/Vasp-like
chr17_-_29648631 16.912 NM_001003927
NM_014210
EVI2A

ecotropic viral integration site 2A

chr14_+_64971504 16.630 ZBTB1
zinc finger and BTB domain containing 1
chr17_-_29641094 16.395 NM_006495
EVI2B
ecotropic viral integration site 2B
chr15_+_77287738 16.332 PSTPIP1
proline-serine-threonine phosphatase interacting protein 1
chr1_+_209929378 16.235 NM_025228
TRAF3IP3
TRAF3 interacting protein 3
chr5_-_149466173 16.234 CSF1R
colony stimulating factor 1 receptor
chr12_-_89746238 16.127 DUSP6
dual specificity phosphatase 6
chr12_-_9760481 16.072 NM_002258
KLRB1
killer cell lectin-like receptor subfamily B, member 1
chrX_-_53449548 16.038 SMC1A
structural maintenance of chromosomes 1A
chr22_+_23222897 15.973 CYAT1
immunoglobulin lambda light chain-like
chrX_+_119737743 15.958 NM_014060
MCTS1
malignant T cell amplified sequence 1
chrX_+_48542193 15.877 WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr5_+_115898218 15.843


chr18_-_18691765 15.842 NM_005406
ROCK1
Rho-associated, coiled-coil containing protein kinase 1
chr17_+_42422665 15.802 GRN
granulin
chr2_-_96811138 15.785 NM_004418
DUSP2
dual specificity phosphatase 2
chr17_-_62084282 15.662 NM_000873
ICAM2
intercellular adhesion molecule 2
chr11_-_33890931 15.658 LMO2
LIM domain only 2 (rhombotin-like 1)
chr5_+_118691692 15.638 TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr4_+_103422822 15.599 NFKB1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
chr8_-_101733735 15.598 PABPC1
poly(A) binding protein, cytoplasmic 1
chr2_+_233925035 15.567 NM_001017915
NM_005541
INPP5D

inositol polyphosphate-5-phosphatase, 145kDa

chr15_+_77287688 15.490 PSTPIP1
proline-serine-threonine phosphatase interacting protein 1
chr6_-_24936177 15.267 FAM65B
family with sequence similarity 65, member B
chr15_+_75074714 15.154 CSK
c-src tyrosine kinase
chr17_-_29641087 15.070 EVI2B
ecotropic viral integration site 2B
chr1_-_153919140 15.009 NM_014856
DENND4B
DENN/MADD domain containing 4B
chr6_-_32634287 14.984 NM_001243961
NM_002123
HLA-DQB1

major histocompatibility complex, class II, DQ beta 1

chr19_+_39109831 14.979 EIF3K
eukaryotic translation initiation factor 3, subunit K
chr12_-_89745997 14.858 DUSP6
dual specificity phosphatase 6
chr16_+_30194730 14.846 NM_001193333
NM_007074
CORO1A

coronin, actin binding protein, 1A

chr10_-_27149892 14.826 ABI1
abl-interactor 1
chrX_-_135863104 14.744 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr6_+_31582978 14.677 NM_004847
NM_001623
AIF1

allograft inflammatory factor 1

chr1_-_25291474 14.630 NM_001031680
RUNX3
runt-related transcription factor 3
chr22_-_37640287 14.606 NM_002872
RAC2
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr8_+_98703361 14.566 MTDH
metadherin
chr19_-_51875790 14.511 NM_005601
NKG7
natural killer cell group 7 sequence
chr13_-_49110117 14.482 RCBTB2
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
chrX_-_70331297 14.468 NM_000206
IL2RG
interleukin 2 receptor, gamma
chr2_-_55496314 14.465 NM_001005369
MTIF2
mitochondrial translational initiation factor 2
chrX_-_135863033 14.427 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr3_-_150263899 14.330 SERP1
stress-associated endoplasmic reticulum protein 1
chr19_-_39826676 14.325 NM_004877
GMFG
glia maturation factor, gamma
chrX_+_119738542 14.252 NM_001137554
MCTS1
malignant T cell amplified sequence 1
chrX_+_123234462 14.252 STAG2
stromal antigen 2
chr15_+_75074417 14.214 NM_001127190
NM_004383
CSK

c-src tyrosine kinase

chr12_-_89746244 14.147 NM_001946
NM_022652
DUSP6

dual specificity phosphatase 6

chr19_+_39109807 14.129 EIF3K
eukaryotic translation initiation factor 3, subunit K
chr11_-_33891361 14.107 NM_001142316
LMO2
LIM domain only 2 (rhombotin-like 1)
chr15_+_77287428 14.049 NM_003978
PSTPIP1
proline-serine-threonine phosphatase interacting protein 1
chr19_-_39826625 13.949 GMFG
glia maturation factor, gamma
chrX_-_20285141 13.913 RPS6KA3
ribosomal protein S6 kinase, 90kDa, polypeptide 3
chrX_-_129244652 13.867 NM_001127197
ELF4
E74-like factor 4 (ets domain transcription factor)
chr1_-_59248287 13.759 JUN
jun proto-oncogene
chr3_+_158519925 13.679 MFSD1
major facilitator superfamily domain containing 1
chr16_+_28505920 13.572 NM_018690
APOBR
apolipoprotein B receptor
chr1_-_27226928 13.410 GPATCH3
G patch domain containing 3
chr4_-_185395616 13.358 NM_002199
IRF2
interferon regulatory factor 2
chr5_+_169064238 13.287 NM_004946
DOCK2
dedicator of cytokinesis 2
chr5_-_150466696 13.262 NM_001252391
NM_001252392
TNIP1

TNFAIP3 interacting protein 1

chr11_+_75110552 13.194 NM_001005
RPS3
ribosomal protein S3
chr8_+_22437983 13.144 NM_176871
NM_198042
PDLIM2

PDZ and LIM domain 2 (mystique)

chr11_+_121461070 13.010 SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr5_-_149466094 12.850 CSF1R
colony stimulating factor 1 receptor
chr11_-_67205151 12.847 NM_005608
PTPRCAP
protein tyrosine phosphatase, receptor type, C-associated protein
chr11_-_33891258 12.823 LMO2
LIM domain only 2 (rhombotin-like 1)
chr19_+_1067293 12.778 HMHA1
histocompatibility (minor) HA-1
chr11_-_16996559 12.777 RPL36A
ribosomal protein L36a
chr7_+_143079354 12.716 ZYX
zyxin
chr2_+_219081864 12.694 NM_152862
ARPC2
actin related protein 2/3 complex, subunit 2, 34kDa
chr1_-_207095198 12.650 NM_001193338
NM_001142473
NM_005449
FAIM3


Fas apoptotic inhibitory molecule 3


chr21_-_46340821 12.402 ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr21_-_46340776 12.386 ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr5_-_150467220 12.368 NM_001252390
TNIP1
TNFAIP3 interacting protein 1
chr19_+_1067536 12.357 HMHA1
histocompatibility (minor) HA-1
chr4_-_103748966 12.356 NM_003340
NM_181886
NM_181888
NM_181889
UBE2D3



ubiquitin-conjugating enzyme E2D 3



chr19_+_1067114 12.347 NM_012292
HMHA1
histocompatibility (minor) HA-1
chrX_+_37639246 12.332 NM_000397
CYBB
cytochrome b-245, beta polypeptide
chr11_+_308106 12.233 NM_006435
IFITM2
interferon induced transmembrane protein 2 (1-8D)
chr2_+_68592317 12.066 NM_002664
PLEK
pleckstrin
chr21_-_46340874 12.019 NM_000211
ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr2_-_55496347 11.968 NM_002453
MTIF2
mitochondrial translational initiation factor 2
chr2_+_233925104 11.895 INPP5D
inositol polyphosphate-5-phosphatase, 145kDa
chr6_-_32160637 11.880 GPSM3
G-protein signaling modulator 3
chrX_+_119737984 11.854 MCTS1
malignant T cell amplified sequence 1
chr10_+_104535887 11.742 NM_017787
C10orf26
chromosome 10 open reading frame 26
chr1_-_20987881 11.660 DDOST
dolichyl-diphosphooligosaccharide--protein glycosyltransferase
chr8_-_101964248 11.624 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr21_-_46348633 11.573 NM_001127491
ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chrX_+_24073060 11.520 NM_001415
EIF2S3
eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
chr13_-_46756295 11.508 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr1_+_26644458 11.498 CD52
CD52 molecule
chr3_-_129035069 11.483 NM_006026
H1FX
H1 histone family, member X
chr4_+_40198526 11.475 NM_004310
RHOH
ras homolog gene family, member H
chrX_-_47489703 11.395 NM_002621
CFP
complement factor properdin
chr4_+_103422730 11.394 NFKB1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
chr19_-_10450262 11.384 NM_002162
ICAM3
intercellular adhesion molecule 3
chr5_+_96211643 11.351 NM_001130140
NM_022350
ERAP2

endoplasmic reticulum aminopeptidase 2

chr6_+_26368405 11.347 NM_001197246
BTN3A2
butyrophilin, subfamily 3, member A2
chrX_+_24073071 11.344 EIF2S3
eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
chrX_-_73834460 11.337 NM_016120
NM_183353
RLIM

ring finger protein, LIM domain interacting

chr11_-_64645925 11.296 EHD1
EH-domain containing 1
chr4_-_103748254 11.287 NM_181892
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr4_-_25864430 11.279 NM_015187
SEL1L3
sel-1 suppressor of lin-12-like 3 (C. elegans)
chrX_-_47489243 11.268 NM_001145252
CFP
complement factor properdin
chr8_-_146017774 11.267 RPL8
ribosomal protein L8
chr17_-_7297826 11.267 PLSCR3
phospholipid scramblase 3
chr2_+_219082119 11.244 NM_005731
ARPC2
actin related protein 2/3 complex, subunit 2, 34kDa
chr14_-_69354900 11.173 ACTN1
actinin, alpha 1
chr10_+_70715883 11.161 NM_004728
DDX21
DEAD (Asp-Glu-Ala-Asp) box polypeptide 21
chr17_+_7462064 11.145 TNFSF13
tumor necrosis factor (ligand) superfamily, member 13
chr17_+_76164624 11.121 NM_004710
SYNGR2
synaptogyrin 2
chr11_+_65408387 11.119


chr1_-_25256767 11.104 NM_004350
RUNX3
runt-related transcription factor 3
chr13_-_46756326 11.083 NM_002298
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr10_+_106013951 11.055 NM_001191003
GSTO1
glutathione S-transferase omega 1
chr12_-_9102193 11.001 M6PR
mannose-6-phosphate receptor (cation dependent)
chr2_+_233415300 10.865 NM_004846
EIF4E2
eukaryotic translation initiation factor 4E family member 2
chr17_-_42275425 10.742 NM_001098833
NM_020218
ATXN7L3

ataxin 7-like 3

chr17_+_25958245 10.712 LGALS9
lectin, galactoside-binding, soluble, 9
chr10_-_27149989 10.690 NM_001012750
NM_001012751
NM_001012752
NM_001178116
NM_001178119
NM_001178120
NM_001178121
NM_001178122
NM_001178123
NM_001178124
NM_001178125
NM_005470
ABI1











abl-interactor 1











chr6_-_42714547 10.658 TBCC
tubulin folding cofactor C
chr5_+_75699003 10.539 NM_006633
IQGAP2
IQ motif containing GTPase activating protein 2
chr1_-_31230594 10.517 LAPTM5
lysosomal protein transmembrane 5
chr13_+_31287614 10.468 NM_001204406
ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr9_+_100745644 10.467 ANP32B
acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
chr13_+_31309690 10.428 ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr15_-_65281771 10.398 NM_001127889
SPG21
spastic paraplegia 21 (autosomal recessive, Mast syndrome)
chr1_-_150241409 10.397 NM_001077628
NM_001243771
NM_001243772
NM_016022
APH1A



anterior pharynx defective 1 homolog A (C. elegans)



chr17_+_25958257 10.350 LGALS9
lectin, galactoside-binding, soluble, 9
chr7_+_99971132 10.157 PILRA
paired immunoglobin-like type 2 receptor alpha
chr22_-_37640187 10.118 RAC2
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr12_-_9102262 10.117 NM_001207024
NM_002355
M6PR

mannose-6-phosphate receptor (cation dependent)

chr6_-_31324975 10.114 NM_005514
HLA-B
major histocompatibility complex, class I, B
chr9_+_100745456 10.108 NM_006401
ANP32B
acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
chr6_-_31550065 10.092 NM_002341
NM_009588
LTB

lymphotoxin beta (TNF superfamily, member 3)

chr22_+_37257004 10.043 NM_000631
NM_013416
NCF4

neutrophil cytosolic factor 4, 40kDa


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.21 2.72e-51 GO:0009987 cellular process
1.53 6.60e-51 GO:0044260 cellular macromolecule metabolic process
1.39 8.55e-47 GO:0044237 cellular metabolic process
1.44 1.92e-42 GO:0043170 macromolecule metabolic process
2.04 9.88e-41 GO:0002376 immune system process
1.81 3.27e-39 GO:0010467 gene expression
1.31 5.29e-37 GO:0008152 metabolic process
1.81 1.61e-36 GO:0016070 RNA metabolic process
1.33 3.35e-35 GO:0044238 primary metabolic process
1.59 3.05e-34 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.67 4.22e-33 GO:0090304 nucleic acid metabolic process
1.49 9.75e-28 GO:0034641 cellular nitrogen compound metabolic process
2.13 2.48e-27 GO:0006955 immune response
1.56 4.67e-27 GO:0044267 cellular protein metabolic process
1.47 7.98e-27 GO:0006807 nitrogen compound metabolic process
1.69 4.60e-26 GO:0009059 macromolecule biosynthetic process
1.69 1.36e-25 GO:0034645 cellular macromolecule biosynthetic process
2.69 3.11e-23 GO:0006412 translation
1.23 1.26e-20 GO:0050789 regulation of biological process
1.50 2.64e-20 GO:0044249 cellular biosynthetic process
2.01 4.74e-20 GO:0002682 regulation of immune system process
1.23 9.93e-20 GO:0050794 regulation of cellular process
2.27 1.07e-19 GO:0050776 regulation of immune response
2.04 1.37e-19 GO:0006396 RNA processing
1.21 2.65e-19 GO:0065007 biological regulation
1.47 6.50e-19 GO:0009058 biosynthetic process
3.78 1.03e-18 GO:0006414 translational elongation
1.41 2.40e-18 GO:0019538 protein metabolic process
1.80 4.61e-18 GO:0032774 RNA biosynthetic process
3.30 7.12e-18 GO:0019058 viral infectious cycle
1.37 1.14e-17 GO:0071840 cellular component organization or biogenesis
3.91 4.42e-17 GO:0019080 viral genome expression
3.91 4.42e-17 GO:0019083 viral transcription
2.18 8.14e-17 GO:0002684 positive regulation of immune system process
1.45 8.76e-17 GO:0006950 response to stress
3.04 1.03e-16 GO:0022415 viral reproductive process
2.05 3.11e-16 GO:0016071 mRNA metabolic process
2.89 3.91e-16 GO:0002757 immune response-activating signal transduction
3.78 3.92e-16 GO:0006415 translational termination
2.40 9.69e-16 GO:0008380 RNA splicing
1.36 1.27e-15 GO:0016043 cellular component organization
1.35 1.37e-15 GO:0007165 signal transduction
2.27 1.62e-15 GO:0044419 interspecies interaction between organisms
2.82 2.06e-15 GO:0002764 immune response-regulating signaling pathway
3.40 2.19e-15 GO:0032984 macromolecular complex disassembly
3.40 2.19e-15 GO:0034623 cellular macromolecular complex disassembly
1.80 4.51e-15 GO:0006952 defense response
1.40 7.00e-15 GO:0071841 cellular component organization or biogenesis at cellular level
2.74 1.50e-14 GO:0022411 cellular component disassembly
2.74 1.50e-14 GO:0071845 cellular component disassembly at cellular level
3.49 1.92e-14 GO:0043241 protein complex disassembly
3.49 1.92e-14 GO:0043624 cellular protein complex disassembly
2.18 2.31e-14 GO:0006397 mRNA processing
1.30 3.55e-14 GO:0051716 cellular response to stimulus
1.74 6.09e-14 GO:0051704 multi-organism process
2.65 6.69e-13 GO:0050867 positive regulation of cell activation
1.38 8.07e-13 GO:0071842 cellular component organization at cellular level
1.98 8.30e-13 GO:0034621 cellular macromolecular complex subunit organization
2.59 1.10e-12 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
2.59 1.10e-12 GO:0000398 nuclear mRNA splicing, via spliceosome
1.37 1.15e-12 GO:0048518 positive regulation of biological process
3.35 1.47e-12 GO:0050851 antigen receptor-mediated signaling pathway
2.56 1.64e-12 GO:0000375 RNA splicing, via transesterification reactions
2.69 2.64e-12 GO:0051251 positive regulation of lymphocyte activation
2.62 3.43e-12 GO:0002696 positive regulation of leukocyte activation
1.39 7.53e-12 GO:0048519 negative regulation of biological process
2.25 8.36e-12 GO:0050778 positive regulation of immune response
1.93 1.65e-11 GO:0001775 cell activation
1.38 1.74e-11 GO:0048522 positive regulation of cellular process
3.15 1.78e-11 GO:0002429 immune response-activating cell surface receptor signaling pathway
1.20 2.12e-11 GO:0050896 response to stimulus
1.44 2.17e-11 GO:0048583 regulation of response to stimulus
2.41 2.24e-11 GO:0002253 activation of immune response
2.02 2.60e-11 GO:0016032 viral reproduction
2.07 5.02e-11 GO:0045087 innate immune response
1.68 5.93e-11 GO:0043933 macromolecular complex subunit organization
1.28 8.65e-11 GO:0023052 signaling
2.32 9.05e-11 GO:0045321 leukocyte activation
3.03 1.22e-10 GO:0002768 immune response-regulating cell surface receptor signaling pathway
2.39 1.37e-10 GO:0051249 regulation of lymphocyte activation
2.76 1.54e-10 GO:0050870 positive regulation of T cell activation
2.91 1.55e-10 GO:0031018 endocrine pancreas development
1.39 1.96e-10 GO:0048523 negative regulation of cellular process
1.80 2.88e-10 GO:0071822 protein complex subunit organization
1.28 3.15e-10 GO:0031323 regulation of cellular metabolic process
1.68 4.81e-10 GO:0046907 intracellular transport
2.51 1.08e-09 GO:0050863 regulation of T cell activation
1.29 1.51e-09 GO:0060255 regulation of macromolecule metabolic process
2.25 1.53e-09 GO:0002694 regulation of leukocyte activation
1.26 1.55e-09 GO:0019222 regulation of metabolic process
2.22 1.79e-09 GO:0050865 regulation of cell activation
2.64 2.77e-09 GO:0031016 pancreas development
1.56 3.78e-09 GO:0042981 regulation of apoptosis
1.55 5.19e-09 GO:0043067 regulation of programmed cell death
2.79 5.83e-09 GO:0042110 T cell activation
4.22 6.39e-09 GO:0006413 translational initiation
1.54 8.63e-09 GO:0010941 regulation of cell death
1.27 1.16e-08 GO:0080090 regulation of primary metabolic process
1.39 1.73e-08 GO:0006464 protein modification process
3.46 1.95e-08 GO:0031294 lymphocyte costimulation
3.46 1.95e-08 GO:0031295 T cell costimulation
3.21 2.06e-08 GO:0050852 T cell receptor signaling pathway
2.32 2.94e-08 GO:0046649 lymphocyte activation
1.39 3.38e-08 GO:0007166 cell surface receptor linked signaling pathway
1.37 4.06e-08 GO:0043412 macromolecule modification
1.57 1.05e-07 GO:0006351 transcription, DNA-dependent
1.46 1.14e-07 GO:0051641 cellular localization
1.54 4.91e-07 GO:0009611 response to wounding
1.75 5.17e-07 GO:0007596 blood coagulation
1.75 5.17e-07 GO:0050817 coagulation
1.29 7.92e-07 GO:0010468 regulation of gene expression
1.74 8.15e-07 GO:0007599 hemostasis
2.37 8.81e-07 GO:0050900 leukocyte migration
2.99 8.81e-07 GO:0008063 Toll signaling pathway
1.46 1.06e-06 GO:0010604 positive regulation of macromolecule metabolic process
1.56 1.35e-06 GO:0048584 positive regulation of response to stimulus
2.19 1.36e-06 GO:0022613 ribonucleoprotein complex biogenesis
1.65 1.38e-06 GO:0009057 macromolecule catabolic process
1.47 1.58e-06 GO:0051649 establishment of localization in cell
2.24 1.70e-06 GO:0035270 endocrine system development
1.71 1.77e-06 GO:0070727 cellular macromolecule localization
1.43 1.84e-06 GO:0009893 positive regulation of metabolic process
1.70 2.07e-06 GO:0044265 cellular macromolecule catabolic process
1.45 2.30e-06 GO:0031325 positive regulation of cellular metabolic process
1.70 2.34e-06 GO:0034613 cellular protein localization
1.49 2.34e-06 GO:0009892 negative regulation of metabolic process
1.37 2.43e-06 GO:0006996 organelle organization
3.10 3.16e-06 GO:0002756 MyD88-independent toll-like receptor signaling pathway
1.41 3.73e-06 GO:0035556 intracellular signal transduction
2.91 4.13e-06 GO:0034142 toll-like receptor 4 signaling pathway
1.52 4.84e-06 GO:0015031 protein transport
1.96 4.93e-06 GO:0010608 posttranscriptional regulation of gene expression
2.11 5.33e-06 GO:0071843 cellular component biogenesis at cellular level
1.50 5.59e-06 GO:0010605 negative regulation of macromolecule metabolic process
1.44 5.87e-06 GO:0044085 cellular component biogenesis
1.50 6.60e-06 GO:0031324 negative regulation of cellular metabolic process
1.51 6.96e-06 GO:0045184 establishment of protein localization
2.10 9.16e-06 GO:0006605 protein targeting
1.78 1.08e-05 GO:0006886 intracellular protein transport
1.64 1.20e-05 GO:0050878 regulation of body fluid levels
1.28 1.24e-05 GO:0010556 regulation of macromolecule biosynthetic process
1.43 1.67e-05 GO:0044248 cellular catabolic process
3.04 1.95e-05 GO:0060333 interferon-gamma-mediated signaling pathway
2.92 1.96e-05 GO:0034130 toll-like receptor 1 signaling pathway
2.92 1.96e-05 GO:0034134 toll-like receptor 2 signaling pathway
2.61 2.83e-05 GO:0002758 innate immune response-activating signal transduction
2.99 3.08e-05 GO:0034138 toll-like receptor 3 signaling pathway
1.86 3.24e-05 GO:0034097 response to cytokine stimulus
1.39 3.44e-05 GO:0033036 macromolecule localization
1.68 3.62e-05 GO:0006325 chromatin organization
1.78 3.65e-05 GO:0016568 chromatin modification
1.43 3.84e-05 GO:0008104 protein localization
1.57 4.45e-05 GO:0071310 cellular response to organic substance
2.36 4.48e-05 GO:0045089 positive regulation of innate immune response
1.26 4.56e-05 GO:0031326 regulation of cellular biosynthetic process
1.25 5.51e-05 GO:0009889 regulation of biosynthetic process
2.56 5.63e-05 GO:0002218 activation of innate immune response
2.87 5.82e-05 GO:0071346 cellular response to interferon-gamma
1.59 6.75e-05 GO:0042060 wound healing
2.11 6.98e-05 GO:0045088 regulation of innate immune response
1.44 8.19e-05 GO:0032268 regulation of cellular protein metabolic process
1.54 8.76e-05 GO:0031327 negative regulation of cellular biosynthetic process
2.00 8.86e-05 GO:0033365 protein localization to organelle
1.57 8.95e-05 GO:0051276 chromosome organization
1.64 9.12e-05 GO:0009607 response to biotic stimulus
1.84 9.38e-05 GO:0006366 transcription from RNA polymerase II promoter
2.76 1.01e-04 GO:0002755 MyD88-dependent toll-like receptor signaling pathway
1.26 1.03e-04 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.42 1.09e-04 GO:0051246 regulation of protein metabolic process
2.14 1.11e-04 GO:0006417 regulation of translation
1.48 1.24e-04 GO:0031328 positive regulation of cellular biosynthetic process
2.60 1.34e-04 GO:0002224 toll-like receptor signaling pathway
1.79 1.36e-04 GO:0031347 regulation of defense response
2.56 1.41e-04 GO:0002221 pattern recognition receptor signaling pathway
1.35 1.42e-04 GO:0009056 catabolic process
2.31 1.43e-04 GO:0042254 ribosome biogenesis
1.47 1.55e-04 GO:0009891 positive regulation of biosynthetic process
2.21 1.55e-04 GO:0043122 regulation of I-kappaB kinase/NF-kappaB cascade
2.11 1.78e-04 GO:0031349 positive regulation of defense response
2.27 1.81e-04 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB cascade
1.52 2.02e-04 GO:0009890 negative regulation of biosynthetic process
2.32 2.65e-04 GO:0017038 protein import
1.53 3.12e-04 GO:0010558 negative regulation of macromolecule biosynthetic process
1.43 3.22e-04 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.26 3.35e-04 GO:0051252 regulation of RNA metabolic process
2.51 3.67e-04 GO:0006364 rRNA processing
1.74 3.73e-04 GO:0018193 peptidyl-amino acid modification
1.94 4.01e-04 GO:0071345 cellular response to cytokine stimulus
1.49 4.11e-04 GO:0010557 positive regulation of macromolecule biosynthetic process
1.36 4.89e-04 GO:0010033 response to organic substance
1.66 5.41e-04 GO:0051707 response to other organism
1.98 6.87e-04 GO:0019221 cytokine-mediated signaling pathway
3.05 6.89e-04 GO:0051403 stress-activated MAPK cascade
1.54 6.93e-04 GO:0010629 negative regulation of gene expression
1.86 9.18e-04 GO:0030097 hemopoiesis
1.80 1.02e-03 GO:0001817 regulation of cytokine production
2.52 1.23e-03 GO:0034341 response to interferon-gamma
1.99 1.56e-03 GO:0006913 nucleocytoplasmic transport
1.79 1.60e-03 GO:0048534 hemopoietic or lymphoid organ development
2.18 1.67e-03 GO:0045333 cellular respiration
1.51 1.70e-03 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
2.38 1.72e-03 GO:0016072 rRNA metabolic process
1.25 1.73e-03 GO:0042221 response to chemical stimulus
1.98 1.91e-03 GO:0016569 covalent chromatin modification
1.51 1.95e-03 GO:0051172 negative regulation of nitrogen compound metabolic process
1.22 2.14e-03 GO:0051171 regulation of nitrogen compound metabolic process
1.73 2.17e-03 GO:0048610 cellular process involved in reproduction
1.96 2.34e-03 GO:0051169 nuclear transport
1.97 2.60e-03 GO:0016570 histone modification
2.15 2.73e-03 GO:0002521 leukocyte differentiation
1.54 2.78e-03 GO:0051253 negative regulation of RNA metabolic process
1.48 3.46e-03 GO:0051254 positive regulation of RNA metabolic process
1.55 3.50e-03 GO:0080134 regulation of response to stress
1.41 3.67e-03 GO:0016265 death
1.73 3.74e-03 GO:0002520 immune system development
1.41 4.15e-03 GO:0008219 cell death
1.49 4.80e-03 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
2.00 4.84e-03 GO:0009615 response to virus
1.46 5.13e-03 GO:0065003 macromolecular complex assembly
1.53 5.14e-03 GO:0045892 negative regulation of transcription, DNA-dependent
2.17 5.47e-03 GO:0007265 Ras protein signal transduction
2.77 5.85e-03 GO:0006968 cellular defense response
2.45 5.85e-03 GO:0006839 mitochondrial transport
1.21 6.41e-03 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
3.09 6.42e-03 GO:0045582 positive regulation of T cell differentiation
1.44 6.87e-03 GO:0006915 apoptosis
1.41 7.11e-03 GO:0033554 cellular response to stress
2.95 8.18e-03 GO:0045621 positive regulation of lymphocyte differentiation
1.73 8.38e-03 GO:0034660 ncRNA metabolic process
4.47 8.80e-03 GO:0042274 ribosomal small subunit biogenesis
1.36 8.87e-03 GO:0006793 phosphorus metabolic process
1.36 8.87e-03 GO:0006796 phosphate metabolic process
2.26 9.48e-03 GO:0030098 lymphocyte differentiation
1.18 9.87e-03 GO:0051179 localization
1.43 1.03e-02 GO:0012501 programmed cell death
1.38 1.11e-02 GO:0070887 cellular response to chemical stimulus
1.58 1.15e-02 GO:0007243 intracellular protein kinase cascade
1.58 1.15e-02 GO:0023014 signal transduction via phosphorylation event
2.26 1.30e-02 GO:0022904 respiratory electron transport chain
1.59 1.38e-02 GO:0006091 generation of precursor metabolites and energy
1.35 1.41e-02 GO:0022607 cellular component assembly
1.86 1.52e-02 GO:0034470 ncRNA processing
1.64 1.54e-02 GO:0051603 proteolysis involved in cellular protein catabolic process
1.39 1.55e-02 GO:0016310 phosphorylation
1.44 1.65e-02 GO:0010628 positive regulation of gene expression
1.46 1.84e-02 GO:0051726 regulation of cell cycle
1.46 1.91e-02 GO:0045893 positive regulation of transcription, DNA-dependent
1.41 1.98e-02 GO:0016192 vesicle-mediated transport
1.63 2.00e-02 GO:0070647 protein modification by small protein conjugation or removal
1.50 2.13e-02 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.60 2.15e-02 GO:0034622 cellular macromolecular complex assembly
1.40 2.16e-02 GO:0051173 positive regulation of nitrogen compound metabolic process
1.58 2.28e-02 GO:0010627 regulation of intracellular protein kinase cascade
1.41 2.34e-02 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.63 2.61e-02 GO:0043632 modification-dependent macromolecule catabolic process
2.52 2.64e-02 GO:0030217 T cell differentiation
1.61 3.30e-02 GO:0044257 cellular protein catabolic process
2.38 3.64e-02 GO:0006606 protein import into nucleus
2.38 3.64e-02 GO:0071216 cellular response to biotic stimulus
2.48 3.64e-02 GO:0034340 response to type I interferon
1.49 3.74e-02 GO:0043065 positive regulation of apoptosis
1.62 3.85e-02 GO:0019941 modification-dependent protein catabolic process
1.48 3.87e-02 GO:0010942 positive regulation of cell death
1.68 3.97e-02 GO:0015980 energy derivation by oxidation of organic compounds
1.46 4.81e-02 GO:0006928 cellular component movement
1.22 4.92e-02 GO:0006355 regulation of transcription, DNA-dependent

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.20 3.73e-51 GO:0044424 intracellular part
1.19 1.37e-49 GO:0005622 intracellular
1.26 8.53e-37 GO:0005737 cytoplasm
1.21 3.39e-35 GO:0043226 organelle
1.24 3.55e-35 GO:0043227 membrane-bounded organelle
1.21 4.85e-35 GO:0043229 intracellular organelle
1.23 1.53e-34 GO:0043231 intracellular membrane-bounded organelle
1.35 1.85e-34 GO:0044446 intracellular organelle part
1.35 4.30e-34 GO:0044422 organelle part
1.47 2.78e-32 GO:0032991 macromolecular complex
1.32 4.31e-31 GO:0044444 cytoplasmic part
2.43 5.99e-31 GO:0030529 ribonucleoprotein complex
1.59 3.82e-30 GO:0031974 membrane-enclosed lumen
1.62 4.81e-30 GO:0044428 nuclear part
1.62 1.46e-28 GO:0005829 cytosol
1.58 5.91e-28 GO:0043233 organelle lumen
1.58 2.39e-27 GO:0070013 intracellular organelle lumen
1.65 8.14e-27 GO:0031981 nuclear lumen
1.72 9.71e-23 GO:0005654 nucleoplasm
1.28 5.42e-22 GO:0005634 nucleus
1.06 1.99e-16 GO:0044464 cell part
1.06 2.15e-16 GO:0005623 cell
2.68 1.94e-14 GO:0005840 ribosome
1.33 9.73e-13 GO:0043234 protein complex
3.60 1.21e-12 GO:0022626 cytosolic ribosome
2.72 9.56e-11 GO:0005681 spliceosomal complex
2.52 9.77e-10 GO:0044445 cytosolic part
1.31 1.80e-09 GO:0043228 non-membrane-bounded organelle
1.31 1.80e-09 GO:0043232 intracellular non-membrane-bounded organelle
1.65 2.56e-09 GO:0044451 nucleoplasm part
2.65 8.55e-09 GO:0044455 mitochondrial membrane part
1.62 1.23e-08 GO:0031975 envelope
2.17 1.47e-08 GO:0016604 nuclear body
1.62 1.87e-08 GO:0031967 organelle envelope
1.33 7.28e-08 GO:0031090 organelle membrane
3.86 6.17e-07 GO:0022625 cytosolic large ribosomal subunit
1.84 8.95e-07 GO:0019866 organelle inner membrane
2.80 2.15e-06 GO:0071013 catalytic step 2 spliceosome
1.93 3.69e-06 GO:0044440 endosomal part
1.65 4.72e-06 GO:0005730 nucleolus
1.83 5.66e-06 GO:0005743 mitochondrial inner membrane
1.92 6.04e-06 GO:0010008 endosome membrane
2.33 1.62e-05 GO:0016607 nuclear speck
2.88 4.19e-05 GO:0015934 large ribosomal subunit
1.62 4.54e-05 GO:0005740 mitochondrial envelope
1.64 5.31e-05 GO:0031966 mitochondrial membrane
1.49 1.19e-04 GO:0044429 mitochondrial part
1.60 1.64e-04 GO:0005768 endosome
2.77 1.82e-04 GO:0005746 mitochondrial respiratory chain
3.44 2.32e-04 GO:0022627 cytosolic small ribosomal subunit
2.66 2.95e-04 GO:0070469 respiratory chain
3.96 4.76e-04 GO:0005689 U12-type spliceosomal complex
2.09 5.57e-04 GO:0043235 receptor complex
4.33 7.37e-04 GO:0030530 heterogeneous nuclear ribonucleoprotein complex
5.00 7.67e-04 GO:0005852 eukaryotic translation initiation factor 3 complex
2.44 7.49e-03 GO:0031902 late endosome membrane
1.45 7.56e-03 GO:0005694 chromosome
2.57 9.65e-03 GO:0015935 small ribosomal subunit
1.70 1.01e-02 GO:0000785 chromatin
2.83 1.40e-02 GO:0005747 mitochondrial respiratory chain complex I
2.83 1.40e-02 GO:0030964 NADH dehydrogenase complex
2.83 1.40e-02 GO:0045271 respiratory chain complex I
1.88 1.98e-02 GO:0009897 external side of plasma membrane
5.05 3.13e-02 GO:0016281 eukaryotic translation initiation factor 4F complex
1.26 3.51e-02 GO:0005739 mitochondrion
5.57 4.59e-02 GO:0005885 Arp2/3 protein complex
4.33 4.92e-02 GO:0042101 T cell receptor complex

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.38 4.77e-62 GO:0005515 protein binding
1.16 4.53e-38 GO:0005488 binding
2.05 2.62e-28 GO:0003723 RNA binding
2.87 6.32e-14 GO:0003735 structural constituent of ribosome
1.31 8.01e-13 GO:0003676 nucleic acid binding
1.33 1.24e-08 GO:0000166 nucleotide binding
3.66 8.06e-08 GO:0003743 translation initiation factor activity
2.97 9.52e-08 GO:0008135 translation factor activity, nucleic acid binding
1.80 9.77e-07 GO:0000988 protein binding transcription factor activity
1.80 9.77e-07 GO:0000989 transcription factor binding transcription factor activity
1.79 1.80e-06 GO:0003712 transcription cofactor activity
3.41 5.28e-05 GO:0003823 antigen binding
1.64 6.23e-05 GO:0019904 protein domain specific binding
3.33 1.83e-04 GO:0004715 non-membrane spanning protein tyrosine kinase activity
1.27 6.50e-04 GO:0035639 purine ribonucleoside triphosphate binding
1.44 7.02e-04 GO:0019899 enzyme binding
1.25 2.12e-03 GO:0017076 purine nucleotide binding
1.25 2.34e-03 GO:0032553 ribonucleotide binding
1.25 2.34e-03 GO:0032555 purine ribonucleotide binding
1.68 2.70e-03 GO:0008134 transcription factor binding
1.28 3.15e-03 GO:0005524 ATP binding
2.36 5.13e-03 GO:0003729 mRNA binding
1.27 6.49e-03 GO:0030554 adenyl nucleotide binding
1.26 7.97e-03 GO:0032559 adenyl ribonucleotide binding
1.74 1.10e-02 GO:0003713 transcription coactivator activity
6.50 1.31e-02 GO:0001085 RNA polymerase II transcription factor binding
5.69 1.40e-02 GO:0019864 IgG binding
2.25 1.55e-02 GO:0016651 oxidoreductase activity, acting on NADH or NADPH
2.10 1.92e-02 GO:0051427 hormone receptor binding
4.06 2.39e-02 GO:0019865 immunoglobulin binding
2.17 2.43e-02 GO:0035257 nuclear hormone receptor binding
2.22 2.76e-02 GO:0031625 ubiquitin protein ligase binding
2.72 2.77e-02 GO:0016655 oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor
2.01 3.08e-02 GO:0017124 SH3 domain binding
1.32 3.70e-02 GO:0016772 transferase activity, transferring phosphorus-containing groups
2.81 4.76e-02 GO:0003954 NADH dehydrogenase activity
2.81 4.76e-02 GO:0008137 NADH dehydrogenase (ubiquinone) activity
2.81 4.76e-02 GO:0050136 NADH dehydrogenase (quinone) activity