Motif ID: SPZ1.p2

Z-value: 1.277


Transcription factors associated with SPZ1.p2:

Gene SymbolEntrez IDGene Name
SPZ1 84654 spermatogenic leucine zipper 1



Activity profile for motif SPZ1.p2.

activity profile for motif SPZ1.p2


Sorted Z-values histogram for motif SPZ1.p2

Sorted Z-values for motif SPZ1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SPZ1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr14_-_60337350 28.837 NM_021136
RTN1
reticulon 1
chrX_-_13956530 28.249 GPM6B
glycoprotein M6B
chrX_-_13956644 24.229 NM_001001994
GPM6B
glycoprotein M6B
chrX_-_13956445 22.940


chr20_+_44657858 13.145 SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5
chr6_-_70506843 13.047 NM_018368
LMBRD1
LMBR1 domain containing 1
chr6_-_70506524 12.990 LMBRD1
LMBR1 domain containing 1
chr1_-_182360400 12.942 NM_001033056
GLUL
glutamate-ammonia ligase
chr6_-_70506768 12.531 LMBRD1
LMBR1 domain containing 1
chr6_-_84418705 12.317 NM_001242792
SNAP91
synaptosomal-associated protein, 91kDa homolog (mouse)
chr12_+_79258448 12.052 NM_005639
SYT1
synaptotagmin I
chr17_-_37764165 11.737 NM_006160
NEUROD2
neurogenic differentiation 2
chr12_+_79258588 11.434 SYT1
synaptotagmin I
chr8_-_22089850 11.118 NM_001099335
NM_014759
PHYHIP

phytanoyl-CoA 2-hydroxylase interacting protein

chr19_-_36523770 11.054 NM_015526
CLIP3
CAP-GLY domain containing linker protein 3
chr16_+_2039945 10.983 NM_004209
SYNGR3
synaptogyrin 3
chr6_+_107811272 10.968 NM_018013
SOBP
sine oculis binding protein homolog (Drosophila)
chr13_+_42031525 10.658 NM_014059
C13orf15
chromosome 13 open reading frame 15
chr12_+_79258517 10.616 SYT1
synaptotagmin I
chr22_-_44258210 10.411 NM_014351
SULT4A1
sulfotransferase family 4A, member 1
chr10_+_121485638 10.354 INPP5F
inositol polyphosphate-5-phosphatase F
chr11_+_121322848 10.345 NM_003105
SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr19_-_38720312 10.294 NM_001135156
DPF1
D4, zinc and double PHD fingers family 1
chr16_+_222845 10.186 NM_000517
HBA1
HBA2
hemoglobin, alpha 1
hemoglobin, alpha 2
chrX_+_38420690 10.113 NM_004615
TSPAN7
tetraspanin 7
chr10_+_121485593 10.065 INPP5F
inositol polyphosphate-5-phosphatase F
chr16_+_58498182 9.717 NDRG4
NDRG family member 4
chr16_+_28834407 9.461 NM_007245
NM_145714
NM_148414
NM_148415
NM_148416
ATXN2L




ataxin 2-like




chr6_-_29600959 8.811 NM_001470
NM_021904
GABBR1

gamma-aminobutyric acid (GABA) B receptor, 1

chr12_-_6798419 8.736 ZNF384
zinc finger protein 384
chr3_-_195306274 8.708 APOD
apolipoprotein D
chr8_-_22089517 8.654 PHYHIP
phytanoyl-CoA 2-hydroxylase interacting protein
chr1_+_204797774 8.561 NM_001005388
NM_001005389
NM_001160332
NM_001160333
NM_015090
NFASC




neurofascin




chr6_+_39760772 8.462 NM_015345
DAAM2
dishevelled associated activator of morphogenesis 2
chr13_+_42031690 8.161 C13orf15
chromosome 13 open reading frame 15
chr5_+_137801178 8.120 NM_001964
EGR1
early growth response 1
chr9_+_130548358 8.002 CDK9
cyclin-dependent kinase 9
chr12_-_6798619 7.781 NM_001039920
NM_001135734
ZNF384

zinc finger protein 384

chr17_+_7554415 7.742 ATP1B2
ATPase, Na+/K+ transporting, beta 2 polypeptide
chr6_-_29600668 7.377 GABBR1
gamma-aminobutyric acid (GABA) B receptor, 1
chr1_-_182361311 7.361 NM_001033044
NM_002065
GLUL

glutamate-ammonia ligase

chr9_-_122131579 7.232 NM_014618
DBC1
deleted in bladder cancer 1
chr1_+_2005083 7.165 NM_001033581
PRKCZ
protein kinase C, zeta
chr16_+_28834372 7.139 ATXN2L
ataxin 2-like
chrX_+_117480416 7.080 WDR44
WD repeat domain 44
chr16_+_50099907 6.984 HEATR3
HEAT repeat containing 3
chr8_+_24771276 6.862 NEFM
neurofilament, medium polypeptide
chr16_+_58498725 6.854 NM_022910
NDRG4
NDRG family member 4
chr1_-_32229635 6.810 NM_001703
BAI2
brain-specific angiogenesis inhibitor 2
chr12_-_49392909 6.796 NM_015086
DDN
dendrin
chr1_-_40157067 6.671 NM_016257
HPCAL4
hippocalcin like 4
chr5_+_139493689 6.656 NM_005859
PURA
purine-rich element binding protein A
chr9_-_35115844 6.654 NM_025182
FAM214B
family with sequence similarity 214, member B
chrX_+_70315637 6.643 NM_001170931
NM_005938
FOXO4

forkhead box O4

chr17_-_36956145 6.609 NM_003559
PIP4K2B
phosphatidylinositol-5-phosphate 4-kinase, type II, beta
chr3_-_9834357 6.585 NM_006354
NM_133480
TADA3

transcriptional adaptor 3

chr12_+_112451229 6.546


chr17_-_4046298 6.534 ZZEF1
zinc finger, ZZ-type with EF-hand domain 1
chr16_+_58498216 6.468 NDRG4
NDRG family member 4
chr19_-_36523540 6.454 NM_001199570
CLIP3
CAP-GLY domain containing linker protein 3
chr3_-_187388105 6.413 NM_001048
SST
somatostatin
chr14_-_23821423 6.350 NM_020372
SLC22A17
solute carrier family 22, member 17
chr3_-_13114547 6.304 NM_001134382
IQSEC1
IQ motif and Sec7 domain 1
chr1_-_241520467 6.092 NM_002924
RGS7
regulator of G-protein signaling 7
chr10_+_121485487 6.012 NM_001243195
NM_014937
INPP5F

inositol polyphosphate-5-phosphatase F

chr22_+_50946654 6.009 NCAPH2
non-SMC condensin II complex, subunit H2
chr6_-_70506472 6.002 LMBRD1
LMBR1 domain containing 1
chr6_-_110500803 5.974 WASF1
WAS protein family, member 1
chr1_+_77747727 5.948 AK5
adenylate kinase 5
chr3_+_9834201 5.936 NM_001198793
NM_005718
ARPC4-TTLL3
ARPC4
ARPC4-TTLL3 readthrough
actin related protein 2/3 complex, subunit 4, 20kDa
chr16_+_29912146 5.932 NM_181718
ASPHD1
aspartate beta-hydroxylase domain containing 1
chr6_+_44238479 5.907 NM_001137560
TMEM151B
transmembrane protein 151B
chrX_+_153665468 5.862 GDI1
GDP dissociation inhibitor 1
chr8_+_24771268 5.725 NM_005382
NEFM
neurofilament, medium polypeptide
chr5_+_140346053 5.716 PCDHAC2
protocadherin alpha subfamily C, 2
chr10_+_64133915 5.668 NM_014951
NM_199450
NM_199451
ZNF365


zinc finger protein 365


chr14_-_23822025 5.667 NM_016609
SLC22A17
solute carrier family 22, member 17
chr16_+_28834360 5.613 ATXN2L
ataxin 2-like
chr8_-_80679897 5.598 NM_001040708
NM_012258
HEY1

hairy/enhancer-of-split related with YRPW motif 1

chr6_-_116575170 5.593 NM_021648
TSPYL4
TSPY-like 4
chr15_-_71146427 5.583 NM_018357
NM_197958
LARP6

La ribonucleoprotein domain family, member 6

chr5_+_67511578 5.573 NM_181523
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr19_-_38714781 5.571 NM_001135155
NM_004647
DPF1

D4, zinc and double PHD fingers family 1

chr3_-_18466759 5.550 NM_001195470
NM_002971
SATB1

SATB homeobox 1

chr17_-_40333190 5.519 NM_012285
KCNH4
potassium voltage-gated channel, subfamily H (eag-related), member 4
chr2_-_26205327 5.486 KIF3C
kinesin family member 3C
chr16_+_1386197 5.467 NM_001199096
BAIAP3
BAI1-associated protein 3
chr7_-_103629962 5.383 NM_005045
NM_173054
RELN

reelin

chr1_+_77747602 5.375 NM_174858
AK5
adenylate kinase 5
chr1_+_155853546 5.321 SYT11
synaptotagmin XI
chrX_-_51239426 5.304 NM_018159
NUDT11
nudix (nucleoside diphosphate linked moiety X)-type motif 11
chr5_+_140306301 5.258 NM_018898
NM_031882
PCDHAC1

protocadherin alpha subfamily C, 1

chr1_+_155829259 5.239 NM_152280
SYT11
synaptotagmin XI
chr19_+_51628136 5.194 NM_001198558
NM_014441
SIGLEC9

sialic acid binding Ig-like lectin 9

chr6_-_31514393 5.185 ATP6V1G2
ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
chr15_-_23378217 5.180 HERC2P2
hect domain and RLD 2 pseudogene 2
chr1_-_21995793 5.165 NM_001145657
NM_002885
RAP1GAP

RAP1 GTPase activating protein

chr11_-_46939908 5.088 NM_002334
LRP4
low density lipoprotein receptor-related protein 4
chr7_-_37488408 5.046 ELMO1
engulfment and cell motility 1
chr19_-_6502224 5.035 NM_006087
TUBB4A
tubulin, beta 4A class IVa
chr6_+_42531767 5.008 UBR2
ubiquitin protein ligase E3 component n-recognin 2
chr19_+_16222706 4.971 RAB8A
RAB8A, member RAS oncogene family
chr20_+_44657812 4.970 NM_020708
SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5
chr3_+_167453431 4.958 NM_001122752
NM_005025
SERPINI1

serpin peptidase inhibitor, clade I (neuroserpin), member 1

chr7_-_130080823 4.945 NM_018718
CEP41
centrosomal protein 41kDa
chr18_-_74691951 4.931 MBP
myelin basic protein
chr15_+_74421986 4.927 NM_001130137
ISLR2
immunoglobulin superfamily containing leucine-rich repeat 2
chr6_+_39760148 4.878 NM_001201427
DAAM2
dishevelled associated activator of morphogenesis 2
chr6_-_29600859 4.874 GABBR1
gamma-aminobutyric acid (GABA) B receptor, 1
chr11_-_45687135 4.832 NM_003654
CHST1
carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
chr17_-_40264687 4.830 NM_024119
DHX58
DEXH (Asp-Glu-X-His) box polypeptide 58
chr12_-_120554558 4.823 RAB35
RAB35, member RAS oncogene family
chr12_-_112450914 4.797 NM_001193453
NM_001193531
NM_138341
LOC728543
TMEM116


uncharacterized LOC728543
transmembrane protein 116


chr12_-_110434057 4.770 GIT2
G protein-coupled receptor kinase interacting ArfGAP 2
chr17_-_7517849 4.733 FXR2
fragile X mental retardation, autosomal homolog 2
chr20_+_34742656 4.723 NM_012156
EPB41L1
erythrocyte membrane protein band 4.1-like 1
chr6_+_42981955 4.718 KLHDC3
kelch domain containing 3
chr7_-_37488554 4.676 NM_014800
ELMO1
engulfment and cell motility 1
chr6_+_110012521 4.644 FIG4
FIG4 homolog, SAC1 lipid phosphatase domain containing (S. cerevisiae)
chrX_-_102319080 4.637 BEX1
brain expressed, X-linked 1
chr3_-_133614421 4.636 NM_016577
RAB6B
RAB6B, member RAS oncogene family
chr16_+_28834565 4.601 ATXN2L
ataxin 2-like
chr6_+_110012497 4.581 FIG4
FIG4 homolog, SAC1 lipid phosphatase domain containing (S. cerevisiae)
chr12_-_56101667 4.563 NM_001144996
NM_002206
ITGA7

integrin, alpha 7

chr14_-_74551073 4.551 ALDH6A1
aldehyde dehydrogenase 6 family, member A1
chr12_+_7282963 4.549 NM_014718
CLSTN3
calsyntenin 3
chr2_-_47797469 4.535 NM_022055
KCNK12
potassium channel, subfamily K, member 12
chr14_-_74551159 4.534 NM_005589
ALDH6A1
aldehyde dehydrogenase 6 family, member A1
chr16_+_58283819 4.522 NM_001142302
NM_014157
CCDC113

coiled-coil domain containing 113

chr1_+_65720091 4.508 LOC645195
DNAJC6
uncharacterized LOC645195
DnaJ (Hsp40) homolog, subfamily C, member 6
chr1_+_116915794 4.493 NM_000701
ATP1A1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
chr8_-_27472298 4.468 NM_001831
CLU
clusterin
chrX_-_54384436 4.457 NM_001002838
NM_020922
WNK3

WNK lysine deficient protein kinase 3

chr11_-_75236866 4.392 GDPD5
glycerophosphodiester phosphodiesterase domain containing 5
chr13_+_31191829 4.385 NM_005800
USPL1
ubiquitin specific peptidase like 1
chr10_+_105036783 4.384 NM_032727
INA
internexin neuronal intermediate filament protein, alpha
chr11_-_118661856 4.377 DDX6
DEAD (Asp-Glu-Ala-Asp) box polypeptide 6
chr12_-_6798528 4.357 NM_133476
ZNF384
zinc finger protein 384
chr19_+_47104389 4.350 CALM3
calmodulin 3 (phosphorylase kinase, delta)
chr12_+_120972155 4.349 RNF10
ring finger protein 10
chr11_-_35440514 4.343 SLC1A2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr12_+_113659287 4.212 TPCN1
two pore segment channel 1
chr9_-_94124149 4.212 AUH
AU RNA binding protein/enoyl-CoA hydratase
chr17_+_7554711 4.200 ATP1B2
ATPase, Na+/K+ transporting, beta 2 polypeptide
chr20_+_24449834 4.175 NM_024893
SYNDIG1
synapse differentiation inducing 1
chr7_-_45128492 4.163 NM_001146334
NACAD
NAC alpha domain containing
chr18_+_32558207 4.155 NM_001143827
MAPRE2
microtubule-associated protein, RP/EB family, member 2
chr15_-_73925555 4.132 NPTN
neuroplastin
chr5_+_173472692 4.129 NM_015980
HMP19
HMP19 protein
chr17_-_26903926 4.114 NM_005165
ALDOC
aldolase C, fructose-bisphosphate
chr6_+_42981986 4.101 KLHDC3
kelch domain containing 3
chr5_+_67511601 4.097 PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr20_+_44035203 4.086 NM_001048223
NM_001048224
DBNDD2

dysbindin (dystrobrevin binding protein 1) domain containing 2

chr16_+_6533758 4.077 RBFOX1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr17_+_44068828 4.069 MAPT
microtubule-associated protein tau
chr16_-_67427335 4.039 NM_015964
NM_016140
TPPP3

tubulin polymerization-promoting protein family member 3

chr14_+_71108373 4.036 NM_015351
TTC9
tetratricopeptide repeat domain 9
chr3_+_133465098 4.026 TF
transferrin
chr1_-_182360181 4.024 GLUL
glutamate-ammonia ligase
chr11_+_12132063 4.014 NM_014632
MICAL2
microtubule associated monoxygenase, calponin and LIM domain containing 2
chr6_-_32163890 4.008 NOTCH4
notch 4
chr5_+_156693051 4.001 NM_001037333
NM_001037332
CYFIP2

cytoplasmic FMR1 interacting protein 2

chr11_+_45868956 3.999 NM_021117
CRY2
cryptochrome 2 (photolyase-like)
chr19_+_47104559 3.951 CALM3
calmodulin 3 (phosphorylase kinase, delta)
chr16_-_4322695 3.947 TFAP4
transcription factor AP-4 (activating enhancer binding protein 4)
chr15_-_43029123 3.915 CDAN1
congenital dyserythropoietic anemia, type I
chr3_-_49907304 3.898 NM_024046
CAMKV
CaM kinase-like vesicle-associated
chr15_+_74421698 3.888 NM_001130136
ISLR2
immunoglobulin superfamily containing leucine-rich repeat 2
chr12_+_79258794 3.885 SYT1
synaptotagmin I
chr3_-_9290592 3.883 SRGAP3
SLIT-ROBO Rho GTPase activating protein 3
chr17_+_8339135 3.847 NM_001025579
NM_030808
NDEL1

nudE nuclear distribution gene E homolog (A. nidulans)-like 1

chr6_+_110012423 3.838 NM_014845
FIG4
FIG4 homolog, SAC1 lipid phosphatase domain containing (S. cerevisiae)
chr7_-_99774821 3.835 NM_152742
GPC2
glypican 2
chr12_-_51477299 3.833 NM_030809
CSRNP2
cysteine-serine-rich nuclear protein 2
chr19_+_12949258 3.830 NM_014975
MAST1
microtubule associated serine/threonine kinase 1
chr3_+_9834778 3.816 NM_001198780
ARPC4
actin related protein 2/3 complex, subunit 4, 20kDa
chr6_-_84419018 3.814 SNAP91
synaptosomal-associated protein, 91kDa homolog (mouse)
chr17_-_26903854 3.810 ALDOC
aldolase C, fructose-bisphosphate
chr11_+_73358593 3.806 NM_001130034
NM_001130035
PLEKHB1

pleckstrin homology domain containing, family B (evectins) member 1

chr8_+_85097099 3.796 NM_001100391
RALYL
RALY RNA binding protein-like
chr1_-_32801606 3.796 NM_023009
MARCKSL1
MARCKS-like 1
chr22_+_39745757 3.782 NM_004711
NM_145731
SYNGR1

synaptogyrin 1

chr16_+_29674564 3.779 SPN
sialophorin
chr3_-_122283077 3.774 NM_001146102
NM_001146105
NM_001146104
NM_001146106
PARP9



poly (ADP-ribose) polymerase family, member 9



chr11_+_17757494 3.771 NM_001112741
NM_004976
KCNC1

potassium voltage-gated channel, Shaw-related subfamily, member 1

chr12_+_66218879 3.745 HMGA2
high mobility group AT-hook 2
chr19_-_7934806 3.744 FLJ22184
putative uncharacterized protein FLJ22184
chr14_+_104029278 3.735 NM_032374
APOPT1
apoptogenic 1
chr14_-_60097531 3.731 NM_206852
RTN1
reticulon 1
chr10_+_111969988 3.724 NM_001008541
MXI1
MAX interactor 1
chr1_-_9884024 3.705 CLSTN1
calsyntenin 1
chr19_-_10679328 3.694 CDKN2D
cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
chr9_-_135230129 3.689 SETX
senataxin
chr11_-_62476976 3.686 BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr16_+_75600276 3.685 GABARAPL2
GABA(A) receptor-associated protein-like 2
chr22_+_50946627 3.681 NM_001185011
NM_014551
NM_152299
NCAPH2


non-SMC condensin II complex, subunit H2


chr13_-_80915041 3.668 NM_005842
SPRY2
sprouty homolog 2 (Drosophila)
chr2_-_26205437 3.656 NM_002254
KIF3C
kinesin family member 3C
chr20_+_19193364 3.651 SLC24A3
solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
chr20_+_3451615 3.651 NM_001207047
NM_139321
NM_139322
ATRN


attractin



Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.39 1.52e-27 GO:0023052 signaling
1.14 2.52e-26 GO:0009987 cellular process
1.66 2.67e-25 GO:0007399 nervous system development
1.21 6.94e-25 GO:0065007 biological regulation
1.22 7.59e-22 GO:0050794 regulation of cellular process
1.21 7.49e-21 GO:0050789 regulation of biological process
1.35 5.17e-19 GO:0007165 signal transduction
1.32 2.47e-18 GO:0032502 developmental process
1.45 1.50e-17 GO:0048869 cellular developmental process
1.33 3.66e-17 GO:0007275 multicellular organismal development
1.45 4.44e-17 GO:0030154 cell differentiation
1.70 3.02e-16 GO:0022008 neurogenesis
1.72 5.27e-16 GO:0048699 generation of neurons
1.28 6.12e-16 GO:0051716 cellular response to stimulus
1.36 7.41e-16 GO:0048731 system development
1.24 9.60e-16 GO:0032501 multicellular organismal process
1.33 1.48e-15 GO:0048856 anatomical structure development
1.78 8.36e-15 GO:0030182 neuron differentiation
1.84 9.67e-14 GO:0048666 neuron development
1.63 6.29e-13 GO:0048468 cell development
1.18 1.36e-11 GO:0050896 response to stimulus
1.45 3.19e-11 GO:0009653 anatomical structure morphogenesis
1.40 5.64e-11 GO:0007166 cell surface receptor linked signaling pathway
1.80 1.22e-10 GO:0000904 cell morphogenesis involved in differentiation
1.62 5.09e-10 GO:0007267 cell-cell signaling
1.71 5.87e-10 GO:0000902 cell morphogenesis
1.77 1.14e-09 GO:0019226 transmission of nerve impulse
1.77 1.14e-09 GO:0035637 multicellular organismal signaling
1.81 1.86e-09 GO:0048812 neuron projection morphogenesis
1.81 2.29e-09 GO:0048667 cell morphogenesis involved in neuron differentiation
1.66 4.84e-09 GO:0032989 cellular component morphogenesis
1.79 1.81e-08 GO:0007409 axonogenesis
1.35 2.15e-08 GO:0048583 regulation of response to stimulus
1.77 2.61e-08 GO:0007268 synaptic transmission
1.71 5.37e-08 GO:0031175 neuron projection development
1.52 6.12e-08 GO:0040011 locomotion
1.37 8.42e-08 GO:0023051 regulation of signaling
1.27 9.91e-08 GO:0048518 positive regulation of biological process
1.69 1.03e-07 GO:0032990 cell part morphogenesis
1.69 1.06e-07 GO:0048858 cell projection morphogenesis
1.69 1.23e-07 GO:0007417 central nervous system development
1.48 1.24e-07 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.47 1.75e-07 GO:0007154 cell communication
1.30 2.57e-07 GO:0065008 regulation of biological quality
1.82 7.65e-07 GO:0007411 axon guidance
1.37 1.11e-06 GO:0009966 regulation of signal transduction
1.56 2.35e-06 GO:0007167 enzyme linked receptor protein signaling pathway
1.37 2.66e-06 GO:0035556 intracellular signal transduction
1.56 3.16e-06 GO:0030030 cell projection organization
1.27 5.16e-06 GO:0048519 negative regulation of biological process
1.21 7.57e-06 GO:0051179 localization
1.27 1.14e-05 GO:0048523 negative regulation of cellular process
1.26 2.07e-05 GO:0042221 response to chemical stimulus
1.43 2.36e-05 GO:0050793 regulation of developmental process
1.41 2.76e-05 GO:0006793 phosphorus metabolic process
1.41 2.76e-05 GO:0006796 phosphate metabolic process
1.70 2.89e-05 GO:0007420 brain development
1.46 2.99e-05 GO:0051128 regulation of cellular component organization
1.25 3.37e-05 GO:0048522 positive regulation of cellular process
1.58 3.66e-05 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.43 4.37e-05 GO:0006351 transcription, DNA-dependent
1.35 5.29e-05 GO:0051239 regulation of multicellular organismal process
1.18 5.53e-05 GO:0019222 regulation of metabolic process
1.19 5.69e-05 GO:0031323 regulation of cellular metabolic process
1.49 7.57e-05 GO:0010628 positive regulation of gene expression
1.19 8.42e-05 GO:0080090 regulation of primary metabolic process
1.52 1.30e-04 GO:0009887 organ morphogenesis
1.22 1.95e-04 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.55 2.32e-04 GO:0006935 chemotaxis
1.55 2.32e-04 GO:0042330 taxis
1.27 2.33e-04 GO:0006464 protein modification process
1.27 2.47e-04 GO:0048513 organ development
1.64 2.70e-04 GO:0051056 regulation of small GTPase mediated signal transduction
1.47 3.02e-04 GO:0009719 response to endogenous stimulus
1.44 4.19e-04 GO:2000026 regulation of multicellular organismal development
1.44 5.63e-04 GO:0006468 protein phosphorylation
1.12 6.94e-04 GO:0044238 primary metabolic process
2.20 7.74e-04 GO:0006836 neurotransmitter transport
1.42 8.00e-04 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.79 8.47e-04 GO:0051129 negative regulation of cellular component organization
1.37 8.79e-04 GO:0042127 regulation of cell proliferation
1.67 1.27e-03 GO:0022603 regulation of anatomical structure morphogenesis
1.50 1.38e-03 GO:0045892 negative regulation of transcription, DNA-dependent
1.47 1.50e-03 GO:0009725 response to hormone stimulus
1.55 1.63e-03 GO:0032583 regulation of gene-specific transcription
1.41 1.69e-03 GO:0051173 positive regulation of nitrogen compound metabolic process
1.89 1.79e-03 GO:0030900 forebrain development
1.19 1.89e-03 GO:0051234 establishment of localization
1.34 1.93e-03 GO:0010646 regulation of cell communication
1.19 1.97e-03 GO:0006810 transport
1.10 2.02e-03 GO:0008152 metabolic process
1.18 2.07e-03 GO:0016043 cellular component organization
1.35 2.26e-03 GO:0032879 regulation of localization
1.45 2.50e-03 GO:0045893 positive regulation of transcription, DNA-dependent
1.38 2.65e-03 GO:0016310 phosphorylation
1.17 3.84e-03 GO:0060255 regulation of macromolecule metabolic process
1.19 3.85e-03 GO:0051171 regulation of nitrogen compound metabolic process
1.32 3.96e-03 GO:0010604 positive regulation of macromolecule metabolic process
1.38 4.14e-03 GO:0031328 positive regulation of cellular biosynthetic process
1.30 4.47e-03 GO:0009893 positive regulation of metabolic process
1.47 4.64e-03 GO:0051253 negative regulation of RNA metabolic process
1.62 5.48e-03 GO:0060284 regulation of cell development
1.19 5.98e-03 GO:0031326 regulation of cellular biosynthetic process
1.23 6.13e-03 GO:0043412 macromolecule modification
1.19 6.50e-03 GO:0009889 regulation of biosynthetic process
1.45 6.51e-03 GO:0050878 regulation of body fluid levels
1.42 6.65e-03 GO:0051254 positive regulation of RNA metabolic process
1.37 7.11e-03 GO:0048584 positive regulation of response to stimulus
1.72 7.13e-03 GO:0030168 platelet activation
1.41 7.22e-03 GO:0045595 regulation of cell differentiation
1.43 7.50e-03 GO:0001932 regulation of protein phosphorylation
1.11 8.54e-03 GO:0044237 cellular metabolic process
1.33 8.82e-03 GO:0009605 response to external stimulus
1.36 8.92e-03 GO:0009891 positive regulation of biosynthetic process
1.65 9.11e-03 GO:0051960 regulation of nervous system development
1.16 9.63e-03 GO:0071840 cellular component organization or biogenesis
1.78 1.00e-02 GO:0048732 gland development
1.39 1.01e-02 GO:0010557 positive regulation of macromolecule biosynthetic process
1.40 1.17e-02 GO:0019220 regulation of phosphate metabolic process
1.40 1.17e-02 GO:0051174 regulation of phosphorus metabolic process
1.40 1.23e-02 GO:0042325 regulation of phosphorylation
1.58 1.24e-02 GO:0071495 cellular response to endogenous stimulus
1.26 1.26e-02 GO:0065009 regulation of molecular function
1.39 1.29e-02 GO:0009890 negative regulation of biosynthetic process
1.33 1.69e-02 GO:0032774 RNA biosynthetic process
1.42 1.85e-02 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.40 1.86e-02 GO:0010558 negative regulation of macromolecule biosynthetic process
1.29 1.90e-02 GO:0031325 positive regulation of cellular metabolic process
1.49 2.14e-02 GO:0051094 positive regulation of developmental process
1.41 2.22e-02 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
2.35 2.23e-02 GO:0007269 neurotransmitter secretion
1.39 2.23e-02 GO:0031327 negative regulation of cellular biosynthetic process
1.41 2.36e-02 GO:0051172 negative regulation of nitrogen compound metabolic process
1.58 2.54e-02 GO:0032870 cellular response to hormone stimulus
1.73 2.59e-02 GO:0045664 regulation of neuron differentiation
1.69 2.73e-02 GO:0048011 nerve growth factor receptor signaling pathway
1.65 2.75e-02 GO:0046578 regulation of Ras protein signal transduction
1.50 3.55e-02 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.64 3.96e-02 GO:0050767 regulation of neurogenesis
1.54 4.03e-02 GO:0043434 response to peptide hormone stimulus
2.07 4.23e-02 GO:0021537 telencephalon development
1.59 4.31e-02 GO:0051270 regulation of cellular component movement
1.18 4.45e-02 GO:0071842 cellular component organization at cellular level
1.48 4.63e-02 GO:0040008 regulation of growth

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.40 9.42e-16 GO:0044459 plasma membrane part
1.45 1.37e-10 GO:0031226 intrinsic to plasma membrane
1.46 1.51e-10 GO:0005887 integral to plasma membrane
1.83 3.12e-10 GO:0043005 neuron projection
1.12 9.10e-09 GO:0005737 cytoplasm
1.51 1.07e-08 GO:0042995 cell projection
2.05 7.19e-07 GO:0030424 axon
1.17 4.29e-06 GO:0071944 cell periphery
1.44 7.56e-06 GO:0031982 vesicle
1.17 7.69e-06 GO:0005886 plasma membrane
1.06 1.30e-05 GO:0005622 intracellular
1.07 2.06e-05 GO:0044424 intracellular part
1.61 2.76e-05 GO:0045202 synapse
1.43 3.00e-05 GO:0031410 cytoplasmic vesicle
1.44 3.75e-05 GO:0031988 membrane-bounded vesicle
1.43 6.67e-05 GO:0016023 cytoplasmic membrane-bounded vesicle
1.03 1.79e-04 GO:0044464 cell part
1.03 1.88e-04 GO:0005623 cell
1.42 1.59e-03 GO:0030054 cell junction
1.77 3.81e-03 GO:0043025 neuronal cell body
1.30 5.37e-03 GO:0005794 Golgi apparatus
1.72 9.83e-03 GO:0044297 cell body
1.54 1.36e-02 GO:0044456 synapse part
2.07 1.38e-02 GO:0030139 endocytic vesicle
1.31 1.60e-02 GO:0005626 insoluble fraction
2.09 2.03e-02 GO:0033267 axon part
1.80 2.04e-02 GO:0043235 receptor complex
1.31 2.15e-02 GO:0005624 membrane fraction
1.66 2.22e-02 GO:0030425 dendrite
1.47 2.61e-02 GO:0048471 perinuclear region of cytoplasm
1.25 4.19e-02 GO:0000267 cell fraction
2.14 4.40e-02 GO:0030426 growth cone

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.19 2.54e-18 GO:0005515 protein binding
1.09 1.31e-13 GO:0005488 binding
1.47 1.70e-08 GO:0001071 nucleic acid binding transcription factor activity
1.47 1.70e-08 GO:0003700 sequence-specific DNA binding transcription factor activity
1.52 9.31e-07 GO:0043565 sequence-specific DNA binding
1.50 1.46e-06 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.46 5.13e-06 GO:0016301 kinase activity
1.39 1.83e-05 GO:0030528 transcription regulator activity
1.39 7.38e-05 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.67 1.12e-04 GO:0016563 transcription activator activity
1.47 1.49e-04 GO:0004672 protein kinase activity
1.97 5.82e-04 GO:0005516 calmodulin binding
1.39 1.21e-03 GO:0015075 ion transmembrane transporter activity
1.44 2.05e-03 GO:0008324 cation transmembrane transporter activity
1.44 4.12e-03 GO:0008092 cytoskeletal protein binding
1.36 5.46e-03 GO:0019899 enzyme binding
4.87 9.95e-03 GO:0070742 C2H2 zinc finger domain binding
1.21 1.02e-02 GO:0017076 purine nucleotide binding
1.21 1.02e-02 GO:0032553 ribonucleotide binding
1.21 1.02e-02 GO:0032555 purine ribonucleotide binding
1.46 1.06e-02 GO:0004674 protein serine/threonine kinase activity
3.76 1.41e-02 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity
1.56 1.70e-02 GO:0005083 small GTPase regulator activity
1.29 2.08e-02 GO:0005102 receptor binding
1.30 2.23e-02 GO:0030234 enzyme regulator activity
1.43 2.28e-02 GO:0030695 GTPase regulator activity
1.45 2.69e-02 GO:0022803 passive transmembrane transporter activity
1.42 3.07e-02 GO:0060589 nucleoside-triphosphatase regulator activity
1.22 3.11e-02 GO:0030554 adenyl nucleotide binding
1.22 3.48e-02 GO:0032559 adenyl ribonucleotide binding
1.56 3.50e-02 GO:0005261 cation channel activity
1.21 3.61e-02 GO:0016740 transferase activity
1.29 3.65e-02 GO:0022857 transmembrane transporter activity
1.44 4.00e-02 GO:0015267 channel activity
1.30 4.45e-02 GO:0022891 substrate-specific transmembrane transporter activity
1.51 4.46e-02 GO:0022836 gated channel activity