Motif ID: STAT1,3.p3

Z-value: 1.740


Transcription factors associated with STAT1,3.p3:

Gene SymbolEntrez IDGene Name
STAT1 6772 signal transducer and activator of transcription 1, 91kDa
STAT3 6774 signal transducer and activator of transcription 3 (acute-phase response factor)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
STAT1chr2_-_191878882-0.471.2e-13Click!
STAT3chr17_-_40540359-0.143.4e-02Click!


Activity profile for motif STAT1,3.p3.

activity profile for motif STAT1,3.p3


Sorted Z-values histogram for motif STAT1,3.p3

Sorted Z-values for motif STAT1,3.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of STAT1,3.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_-_90750955 81.422 NM_001141945
ACTA2
actin, alpha 2, smooth muscle, aorta
chr16_+_55515468 72.536 NM_001127891
MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
chr20_+_34556528 50.048 NM_001207076
NM_080834
C20orf152

chromosome 20 open reading frame 152

chr9_-_86571631 50.029 C9orf64
chromosome 9 open reading frame 64
chr9_-_86571533 44.395 C9orf64
chromosome 9 open reading frame 64
chr3_+_128598471 41.249 ACAD9
acyl-CoA dehydrogenase family, member 9
chr5_-_133706717 40.343 CDKL3
cyclin-dependent kinase-like 3
chr9_-_86571652 37.776 NM_032307
C9orf64
chromosome 9 open reading frame 64
chr9_-_130186491 36.773


chr2_+_17935379 33.605 NM_001130009
GEN1
Gen endonuclease homolog 1 (Drosophila)
chr11_+_62104882 30.414 ASRGL1
asparaginase like 1
chr3_-_170626381 29.598 EIF5A2
eukaryotic translation initiation factor 5A2
chr1_-_159046555 29.514 NM_004833
AIM2
absent in melanoma 2
chr16_-_3109335 28.116 LOC100507419
uncharacterized LOC100507419
chr19_+_44645708 27.855 NM_001144824
NM_006630
ZNF234

zinc finger protein 234

chr19_-_44809126 27.069 NM_004234
ZNF235
zinc finger protein 235
chr19_+_44529493 26.904 NM_001129996
NM_013360
ZNF284
ZNF222

zinc finger protein 284
zinc finger protein 222

chr19_+_44576266 25.047 NM_001037813
ZNF284
zinc finger protein 284
chr3_-_170626425 23.782 NM_020390
EIF5A2
eukaryotic translation initiation factor 5A2
chr22_-_31503484 23.217 NM_080430
SELM
selenoprotein M
chr1_-_203155827 22.561 CHI3L1
chitinase 3-like 1 (cartilage glycoprotein-39)
chr14_+_24836144 22.539 NM_001136022
NM_001198967
NFATC4

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4

chr1_+_54519259 21.468 NM_153035
TCEANC2
transcription elongation factor A (SII) N-terminal and central domain containing 2
chr1_-_203155910 21.394 NM_001276
CHI3L1
chitinase 3-like 1 (cartilage glycoprotein-39)
chr6_-_111136616 20.974 CDK19
cyclin-dependent kinase 19
chr11_+_62104773 20.616 NM_001083926
NM_025080
ASRGL1

asparaginase like 1

chr1_-_203155813 19.976 CHI3L1
chitinase 3-like 1 (cartilage glycoprotein-39)
chr5_-_39074478 19.574 RICTOR
RPTOR independent companion of MTOR, complex 2
chr1_-_144994839 19.566 PDE4DIP
phosphodiesterase 4D interacting protein
chr9_+_130186652 19.137 NM_007135
ZNF79
zinc finger protein 79
chr19_+_44617510 18.818 NM_013362
ZNF225
zinc finger protein 225
chr17_-_8079607 18.489 NM_032354
NM_183065
TMEM107

transmembrane protein 107

chr1_-_144994908 18.188 PDE4DIP
phosphodiesterase 4D interacting protein
chr9_+_130186714 17.692 ZNF79
zinc finger protein 79
chr19_+_44556163 17.540 NM_013361
ZNF223
zinc finger protein 223
chr2_+_166150340 17.499 NM_021007
SCN2A
sodium channel, voltage-gated, type II, alpha subunit
chr1_-_203155867 16.862 CHI3L1
chitinase 3-like 1 (cartilage glycoprotein-39)
chr3_+_115342302 16.432 GAP43
growth associated protein 43
chr19_+_10381763 16.040 ICAM1
intercellular adhesion molecule 1
chr11_+_114167168 15.986 NNMT
nicotinamide N-methyltransferase
chr19_+_48867650 15.754 NM_012451
SYNGR4
synaptogyrin 4
chr19_+_44488331 15.722 NM_003445
NM_198089
ZNF155

zinc finger protein 155

chr19_-_38720312 15.344 NM_001135156
DPF1
D4, zinc and double PHD fingers family 1
chr11_+_114167197 15.038 NNMT
nicotinamide N-methyltransferase
chr12_-_56211503 14.704 SARNP
SAP domain containing ribonucleoprotein
chr10_-_61469322 14.693 NM_194298
LOC100129721
SLC16A9
uncharacterized LOC100129721
solute carrier family 16, member 9 (monocarboxylic acid transporter 9)
chr4_-_176733901 14.510 GPM6A
glycoprotein M6A
chr19_+_40502942 13.901 NM_178544
ZNF546
zinc finger protein 546
chr17_+_5972425 13.478 WSCD1
WSC domain containing 1
chr3_+_115342150 13.335 NM_001130064
NM_002045
GAP43

growth associated protein 43

chr5_+_55062712 13.039 NM_001166534
DDX4
DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
chr3_+_46283871 12.949 NM_001164680
NM_001837
NM_178328
NM_178329
CCR3



chemokine (C-C motif) receptor 3



chr15_+_90808833 12.269 NM_001033088
NGRN
neugrin, neurite outgrowth associated
chr10_+_90751044 12.213 FAS
Fas (TNF receptor superfamily, member 6)
chr1_-_144994943 12.196 NM_001002812
NM_014644
NM_001002810
NM_001198834
NM_001195261
PDE4DIP




phosphodiesterase 4D interacting protein




chr19_+_44507076 12.108 NM_006300
ZNF230
zinc finger protein 230
chr10_+_86004808 11.992 NM_001012720
NM_001012722
NM_002921
RGR


retinal G protein coupled receptor


chr10_+_95848811 11.791 NM_001165979
PLCE1
phospholipase C, epsilon 1
chr1_+_176432306 11.594 NM_020318
NM_021936
PAPPA2

pappalysin 2

chr20_+_24449834 11.590 NM_024893
SYNDIG1
synapse differentiation inducing 1
chr19_+_44598479 11.081 NM_013398
ZNF224
zinc finger protein 224
chr3_+_185000714 11.013 NM_001242314
NM_001242317
MAP3K13

mitogen-activated protein kinase kinase kinase 13

chr22_-_31536339 10.062 NM_015715
PLA2G3
phospholipase A2, group III
chr8_-_102803196 10.059 NCALD
neurocalcin delta
chr8_-_57906143 9.889 IMPAD1
inositol monophosphatase domain containing 1
chr5_+_175875372 9.787 FAF2
Fas associated factor family member 2
chr11_+_36616039 9.454 NM_138787
C11orf74
chromosome 11 open reading frame 74
chr19_+_44716683 9.390 NM_182490
ZNF227
zinc finger protein 227
chr1_-_153521717 9.302 NM_002960
S100A3
S100 calcium binding protein A3
chr11_+_61197574 9.286 NM_017841
SDHAF2
succinate dehydrogenase complex assembly factor 2
chr3_+_133495925 9.263 TF
transferrin
chr1_-_42630386 9.225 NM_033553
GUCA2A
guanylate cyclase activator 2A (guanylin)
chr1_-_163113938 9.185 RGS5
regulator of G-protein signaling 5
chr16_+_90168671 9.011 FAM157C
family with sequence similarity 157, member C
chr5_+_133706869 8.876 NM_003337
UBE2B
ubiquitin-conjugating enzyme E2B
chr6_-_28304151 8.705 NM_001243241
NM_001243242
NM_001243244
NM_030899
ZNF323



zinc finger protein 323



chr2_+_218989997 8.686 NM_001168298
CXCR2
chemokine (C-X-C motif) receptor 2
chr5_+_161274196 8.590 NM_000806
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr5_+_31799030 8.581 NM_178140
PDZD2
PDZ domain containing 2
chr5_-_140013285 8.546 NM_001040021
NM_001174104
NM_001174105
CD14


CD14 molecule


chr22_-_50699687 8.501 MAPK12
mitogen-activated protein kinase 12
chrX_+_585078 8.365 NM_000451
NM_006883
SHOX

short stature homeobox

chrY_+_535078 8.346 NM_000451
NM_006883
SHOX

short stature homeobox

chr8_-_102803178 8.160 NCALD
neurocalcin delta
chr6_+_41303527 8.049 NM_001199509
NM_001199510
NM_004828
NCR2


natural cytotoxicity triggering receptor 2


chr19_-_49149252 7.868 NM_001217
CA11
carbonic anhydrase XI
chr11_-_129062092 7.713 NM_001142685
ARHGAP32
Rho GTPase activating protein 32
chr20_-_44880324 7.525 NM_021248
CDH22
cadherin 22, type 2
chr14_-_92414004 7.321 NM_006329
FBLN5
fibulin 5
chr11_-_64490654 7.262 NM_015080
NM_138732
NRXN2

neurexin 2

chr6_+_42531767 7.121 UBR2
ubiquitin protein ligase E3 component n-recognin 2
chr16_-_30798206 7.015 NM_001080417
ZNF629
zinc finger protein 629
chr15_+_27216428 6.980 NM_033223
GABRG3
gamma-aminobutyric acid (GABA) A receptor, gamma 3
chr14_-_105647520 6.915 NM_177533
NUDT14
nudix (nucleoside diphosphate linked moiety X)-type motif 14
chr3_+_23987514 6.677 NM_001145425
NR1D2
nuclear receptor subfamily 1, group D, member 2
chrX_-_100548044 6.613 NM_024885
TAF7L
TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa
chr6_-_27440459 6.510 NM_007149
ZNF184
zinc finger protein 184
chr1_-_161519526 6.488 FCGR3A
Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
chr3_+_132316080 6.327 NM_016557
CCRL1
chemokine (C-C motif) receptor-like 1
chr1_-_203155745 6.320 CHI3L1
chitinase 3-like 1 (cartilage glycoprotein-39)
chr12_+_122064448 6.222 NM_032790
ORAI1
ORAI calcium release-activated calcium modulator 1
chr5_+_140261792 6.162 NM_018904
NM_031865
PCDHA13

protocadherin alpha 13

chr19_-_7812396 5.931 NM_001144893
NM_001144894
NM_001144895
NM_001144896
NM_001144897
NM_001144899
NM_021155
CD209






CD209 molecule






chr1_+_111770280 5.894 NM_001025197
NM_004000
CHI3L2

chitinase 3-like 2

chr1_-_54518886 5.838 TMEM59
transmembrane protein 59
chr10_-_75415748 5.743 NM_001114133
SYNPO2L
synaptopodin 2-like
chr19_-_5839702 5.692 NM_000150
NM_001040701
FUT6

fucosyltransferase 6 (alpha (1,3) fucosyltransferase)

chr14_-_20881577 5.655 NM_007110
TEP1
telomerase-associated protein 1
chr19_+_58144510 5.647 NM_006385
NM_198855
ZNF211

zinc finger protein 211

chr7_-_108096693 5.635 NM_001193582
NM_001193583
NM_001193584
NM_005010
NRCAM



neuronal cell adhesion molecule



chr2_-_68384575 5.584 NM_138458
WDR92
WD repeat domain 92
chr19_-_45004482 5.583 NM_013256
ZNF180
zinc finger protein 180
chrX_+_134866213 5.578 NM_001017436
NM_152582
CT45A3
CT45A4
CT45A2
cancer/testis antigen family 45, member A3
cancer/testis antigen family 45, member A4
cancer/testis antigen family 45, member A2
chr12_-_10151689 5.570 NM_001099431
NM_016509
CLEC1B

C-type lectin domain family 1, member B

chr7_-_99573637 5.532 NM_001185
AZGP1
alpha-2-glycoprotein 1, zinc-binding
chr5_+_175875386 5.353 FAF2
Fas associated factor family member 2
chr5_-_139943829 5.329 APBB3
amyloid beta (A4) precursor protein-binding, family B, member 3
chr17_-_6983503 5.266 NM_006344
NM_182906
CLEC10A

C-type lectin domain family 10, member A

chr3_-_52864687 5.191 NM_001166449
NM_002218
ITIH4

inter-alpha-trypsin inhibitor heavy chain family, member 4

chr19_+_44455379 5.011 NM_013359
ZNF221
zinc finger protein 221
chr2_-_113594325 5.000 NM_000576
IL1B
interleukin 1, beta
chr1_-_161519817 4.964 NM_000569
NM_001127592
FCGR3A

Fc fragment of IgG, low affinity IIIa, receptor (CD16a)

chr6_-_28303910 4.927 NM_001135216
NM_001243243
ZNF323

zinc finger protein 323

chr20_-_23618382 4.925 NM_000099
CST3
cystatin C
chr9_-_23821477 4.907 NM_001171197
ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr1_-_54518790 4.870 TMEM59
transmembrane protein 59
chr1_+_36690038 4.808 THRAP3
thyroid hormone receptor associated protein 3
chr3_-_15900928 4.775 NM_015199
ANKRD28
ankyrin repeat domain 28
chr18_-_52626636 4.681 NM_025214
CCDC68
coiled-coil domain containing 68
chr4_+_126237566 4.403 NM_024582
FAT4
FAT tumor suppressor homolog 4 (Drosophila)
chrX_-_154563735 4.330 NM_001289
CLIC2
chloride intracellular channel 2
chr13_+_25946084 4.326 NM_016529
ATP8A2
ATPase, aminophospholipid transporter, class I, type 8A, member 2
chr5_+_73109342 4.321 NM_001244364
RGNEF
190 kDa guanine nucleotide exchange factor
chr1_+_120049825 4.303 NM_000862
HSD3B1
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
chr5_+_175875355 4.301 NM_014613
FAF2
Fas associated factor family member 2
chr2_-_215896809 4.266 NM_015657
ABCA12
ATP-binding cassette, sub-family A (ABC1), member 12
chr2_+_170366211 4.216 NM_006063
KBTBD10
kelch repeat and BTB (POZ) domain containing 10
chr22_-_50765405 4.163 NM_001001794
FAM116B
family with sequence similarity 116, member B
chr1_-_207119707 4.138 NM_002644
PIGR
polymeric immunoglobulin receptor
chr19_-_4831711 4.130 NM_182919
TICAM1
toll-like receptor adaptor molecule 1
chr19_+_42300521 4.100 NM_001815
CEACAM3
carcinoembryonic antigen-related cell adhesion molecule 3
chr19_-_893215 4.044 NM_005481
MED16
mediator complex subunit 16
chr22_+_36044412 3.950 NM_030641
APOL6
apolipoprotein L, 6
chr6_-_111136506 3.919 CDK19
cyclin-dependent kinase 19
chr19_+_10381516 3.876 NM_000201
ICAM1
intercellular adhesion molecule 1
chr1_-_54518915 3.860 TMEM59
transmembrane protein 59
chr4_-_683107 3.805 MFSD7
major facilitator superfamily domain containing 7
chr3_+_58223228 3.749 NM_020676
ABHD6
abhydrolase domain containing 6
chr1_+_156123321 3.606 NM_001193300
NM_022367
NM_001193302
SEMA4A


sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A


chr17_-_617948 3.514 NM_001128159
NM_018289
VPS53

vacuolar protein sorting 53 homolog (S. cerevisiae)

chr6_+_31540092 3.344 NM_000595
LTA
lymphotoxin alpha (TNF superfamily, member 1)
chr1_-_161601251 3.209 NM_001244753
FCGR3B
Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
chr6_+_36646489 3.205 CDKN1A
cyclin-dependent kinase inhibitor 1A (p21, Cip1)
chr8_+_22853360 3.170 NM_001160037
RHOBTB2
Rho-related BTB domain containing 2
chr9_-_35618300 3.166 NM_001782
CD72
CD72 molecule
chr19_-_36980336 3.125 NM_032838
NM_001145343
NM_001145344
NM_001145345
ZNF566



zinc finger protein 566



chr17_-_3030844 3.004 NM_003555
OR1G1
olfactory receptor, family 1, subfamily G, member 1
chr1_-_54519050 2.998 NM_004872
TMEM59
transmembrane protein 59
chr5_-_139944045 2.991 NM_006051
NM_133172
NM_133173
NM_133174
APBB3



amyloid beta (A4) precursor protein-binding, family B, member 3



chr11_-_102668822 2.920 MMP1
matrix metallopeptidase 1 (interstitial collagenase)
chr11_-_128807712 2.883 NM_001195194
TP53AIP1
tumor protein p53 regulated apoptosis inducing protein 1
chr6_-_35480635 2.852 NM_003322
TULP1
tubby like protein 1
chr4_-_87813546 2.832 NM_144645
C4orf36
chromosome 4 open reading frame 36
chr20_+_34203746 2.781 NM_003116
SPAG4
sperm associated antigen 4
chr8_-_18666295 2.772 NM_206909
PSD3
pleckstrin and Sec7 domain containing 3
chr6_+_31913852 2.769 CFB
complement factor B
chr2_+_103035148 2.756 NM_003853
IL18RAP
interleukin 18 receptor accessory protein
chr5_-_140012730 2.750 CD14
CD14 molecule
chr4_+_148402244 2.722 EDNRA
endothelin receptor type A
chr1_+_196621007 2.718 NM_000186
NM_001014975
CFH

complement factor H

chr16_+_72127614 2.691 NM_014003
DHX38
DEAH (Asp-Glu-Ala-His) box polypeptide 38
chr6_+_31913763 2.677 CFB
complement factor B
chr17_-_48546174 2.667 NM_001267
CHAD
chondroadherin
chr12_-_93964636 2.618


chr10_+_74870209 2.566 NM_015901
NUDT13
nudix (nucleoside diphosphate linked moiety X)-type motif 13
chr6_+_30130982 2.516 NM_033229
TRIM15
tripartite motif containing 15
chr1_+_241695433 2.498 NM_003679
KMO
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr7_-_135662194 2.478 NM_145808
NM_001128619
MTPN
LUZP6
myotrophin
leucine zipper protein 6
chr19_+_35168558 2.477 NM_001012320
NM_018443
ZNF302

zinc finger protein 302

chr16_-_29910340 2.462 NM_001114099
NM_001114100
NM_001243332
NM_001243333
NM_012410
NM_201575
SEZ6L2





seizure related 6 homolog (mouse)-like 2





chr19_+_49977817 2.427 NM_001204503
FLT3LG
fms-related tyrosine kinase 3 ligand
chr17_+_32683470 2.415 NM_005408
CCL13
chemokine (C-C motif) ligand 13
chr19_-_58067724 2.365 NM_001039654
ZNF550
zinc finger protein 550
chr22_-_33402648 2.328 NM_003490
NM_133633
SYN3

synapsin III

chr13_-_99738639 2.299 NM_001130049
NM_015296
DOCK9

dedicator of cytokinesis 9

chr16_-_66952729 2.252 NM_001204744
NM_001204745
NM_001204746
NM_004062
CDH16



cadherin 16, KSP-cadherin



chr12_-_69357019 2.163 NM_001874
CPM
carboxypeptidase M
chr1_-_20250051 2.152 NM_014589
PLA2G2E
phospholipase A2, group IIE
chr4_+_3443659 2.136 HGFAC
HGF activator
chr8_-_42623928 2.103 NM_001199279
NM_004198
CHRNA6

cholinergic receptor, nicotinic, alpha 6

chrX_+_14547419 2.079 NM_001118885
NM_001118886
NM_001171942
NM_002063
GLRA2



glycine receptor, alpha 2



chr19_+_11200146 2.037 LDLR
low density lipoprotein receptor
chr11_-_47470687 1.989 NM_005055
NM_032645
RAPSN

receptor-associated protein of the synapse

chr7_-_72972021 1.977 NM_001197244
NM_001707
BCL7B

B-cell CLL/lymphoma 7B

chr20_+_37101457 1.975 NM_020336
RALGAPB
Ral GTPase activating protein, beta subunit (non-catalytic)
chr17_+_32646058 1.940 NM_005623
CCL8
chemokine (C-C motif) ligand 8
chr3_-_146213721 1.935 NM_001199979
PLSCR2
phospholipid scramblase 2
chr1_-_71513259 1.925 NM_001126044
NM_198714
NM_198715
NM_198716
NM_198717
NM_198718
NM_198719
PTGER3






prostaglandin E receptor 3 (subtype EP3)






chr11_-_102668892 1.897 NM_001145938
NM_002421
MMP1

matrix metallopeptidase 1 (interstitial collagenase)

chr22_-_42526877 1.887 NM_000106
NM_001025161
CYP2D6

cytochrome P450, family 2, subfamily D, polypeptide 6


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.66 7.30e-03 GO:0006952 defense response
4.14 7.31e-03 GO:0006954 inflammatory response
5.07 2.67e-02 GO:0070482 response to oxygen levels

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.43 1.12e-02 GO:0005615 extracellular space
1.77 1.79e-02 GO:0005576 extracellular region

Nothing significant found in function category.