Motif ID: TBP.p2

Z-value: 4.086


Transcription factors associated with TBP.p2:

Gene SymbolEntrez IDGene Name
TBP 6908 TATA box binding protein

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TBPchr6_+_170863420-0.499.5e-15Click!


Activity profile for motif TBP.p2.

activity profile for motif TBP.p2


Sorted Z-values histogram for motif TBP.p2

Sorted Z-values for motif TBP.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TBP.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_-_5248180 114.995 NM_000518
HBB
hemoglobin, beta
chr5_-_42811959 91.322 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr11_+_61129831 86.796 TMEM138
transmembrane protein 138
chr12_-_15038724 82.440 NM_000900
NM_001190839
MGP

matrix Gla protein

chr1_-_59042827 81.505 TACSTD2
tumor-associated calcium signal transducer 2
chr2_-_216300770 76.550 NM_002026
NM_054034
NM_212474
NM_212476
NM_212478
NM_212482
FN1





fibronectin 1





chr7_+_142829169 74.579 NM_002652
PIP
prolactin-induced protein
chr8_-_27472188 71.693 CLU
clusterin
chr16_+_56659584 70.172 NM_175617
MT1E
metallothionein 1E
chr19_-_6720585 68.309 NM_000064
C3
complement component 3
chr16_+_56659679 67.856 MT1E
metallothionein 1E
chr7_+_94024201 60.703 COL1A2
collagen, type I, alpha 2
chr11_+_65190272 59.620


chr16_+_56685810 56.009 NM_005947
MT1B
metallothionein 1B
chr1_+_153330329 55.618 NM_002965
S100A9
S100 calcium binding protein A9
chr3_+_193853937 53.482 HES1
hairy and enhancer of split 1, (Drosophila)
chr3_+_193853930 52.832 NM_005524
HES1
hairy and enhancer of split 1, (Drosophila)
chr1_-_153029987 52.346 NM_005988
SPRR2A
small proline-rich protein 2A
chr1_-_230849863 51.828 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr1_-_153363544 50.830 NM_002964
S100A8
S100 calcium binding protein A8
chr12_-_11463353 50.306 NM_002723
PRB4
proline-rich protein BstNI subfamily 4
chr19_-_36247917 47.546 NM_144617
HSPB6
heat shock protein, alpha-crystallin-related, B6
chr1_-_230849847 45.408 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr21_-_28217272 44.729 ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr16_+_56716378 44.116 NM_005952
MT1X
metallothionein 1X
chr20_-_44540685 43.484 PLTP
phospholipid transfer protein
chr17_+_32582295 42.754 NM_002982
CCL2
chemokine (C-C motif) ligand 2
chr1_+_152647770 42.548 NM_178429
LCE2C
late cornified envelope 2C
chr11_-_5275904 41.223 NM_000184
HBG1
HBG2
hemoglobin, gamma A
hemoglobin, gamma G
chr19_-_33793429 40.958 NM_004364
CEBPA
CCAAT/enhancer binding protein (C/EBP), alpha
chr21_-_28217692 39.898 NM_006988
ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr6_+_31783314 39.415 HSPA1A
HSPA1B
heat shock 70kDa protein 1A
heat shock 70kDa protein 1B
chr8_-_48650703 39.272 NM_005195
CEBPD
CCAAT/enhancer binding protein (C/EBP), delta
chr8_-_27472298 39.127 NM_001831
CLU
clusterin
chr7_+_30951414 38.844 NM_198098
AQP1
aquaporin 1 (Colton blood group)
chr9_+_130911731 38.714 NM_005564
LCN2
lipocalin 2
chr13_-_45150391 38.044 TSC22D1
TSC22 domain family, member 1
chr18_+_29171729 37.506 NM_000371
TTR
transthyretin
chr6_+_31913852 37.205 CFB
complement factor B
chr1_-_153044083 36.347 NM_001017418
SPRR2B
small proline-rich protein 2B
chr21_+_47518012 36.189 NM_001849
NM_058174
NM_058175
COL6A2


collagen, type VI, alpha 2


chr14_+_75745480 36.179 NM_005252
FOS
FBJ murine osteosarcoma viral oncogene homolog
chr6_-_52860076 36.086 NM_001512
GSTA4
glutathione S-transferase alpha 4
chr19_+_859658 36.065 NM_001928
CFD
complement factor D (adipsin)
chr8_-_24814028 34.918 NM_006158
NEFL
neurofilament, light polypeptide
chr6_-_169653922 34.685 THBS2
thrombospondin 2
chr19_-_33793441 34.663 CEBPA
CCAAT/enhancer binding protein (C/EBP), alpha
chr11_-_2906960 34.413 NM_000076
NM_001122630
NM_001122631
CDKN1C


cyclin-dependent kinase inhibitor 1C (p57, Kip2)


chr1_-_149858114 34.176 NM_003528
HIST2H2BE
histone cluster 2, H2be
chr12_-_52886971 33.975 NM_005554
KRT6A
keratin 6A
chr17_-_48278874 33.843 COL1A1
collagen, type I, alpha 1
chr11_-_116708334 33.806 NM_000039
APOA1
apolipoprotein A-I
chr7_+_100770378 33.550 NM_000602
NM_001165413
SERPINE1

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

chr11_-_5255712 33.417 NM_000519
HBD
hemoglobin, delta
chr17_-_39780762 32.999 NM_000422
KRT17
keratin 17
chr5_-_153857782 32.818 HAND1
heart and neural crest derivatives expressed 1
chr16_+_72097124 31.970 NM_020995
HPR
haptoglobin-related protein
chr7_+_75931991 31.605 HSPB1
heat shock 27kDa protein 1
chr11_+_1718424 31.308 NM_001012416
KRTAP5-6
keratin associated protein 5-6
chr4_-_74964836 30.971 CXCL2
chemokine (C-X-C motif) ligand 2
chr12_+_52627007 30.616 KRT7
keratin 7
chr1_+_152635871 30.547 NM_178430
LCE2D
late cornified envelope 2D
chr1_-_203155827 30.261 CHI3L1
chitinase 3-like 1 (cartilage glycoprotein-39)
chr11_-_18270167 29.501 NM_001199744
NM_001127380
NM_030754
SAA2-SAA4
SAA2

SAA2-SAA4 readthrough
serum amyloid A2

chr9_+_124048396 29.464 GSN
gelsolin
chr12_-_53012332 29.419 NM_175068
KRT73
keratin 73
chr1_-_95007139 29.345 NM_001178096
NM_001993
F3

coagulation factor III (thromboplastin, tissue factor)

chr1_-_153013593 29.268 NM_006945
SPRR2D
small proline-rich protein 2D
chr16_+_56966025 28.854 HERPUD1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr16_+_56672577 28.678 NM_005946
MT1A
metallothionein 1A
chr3_-_195310770 28.650 APOD
apolipoprotein D
chr10_-_45474210 28.591 NM_007021
C10orf10
chromosome 10 open reading frame 10
chr9_-_33447527 28.587 NM_004925
AQP3
aquaporin 3 (Gill blood group)
chr11_-_111782447 28.528 NM_001885
CRYAB
crystallin, alpha B
chr11_-_76381787 28.525 NM_001128922
LRRC32
leucine rich repeat containing 32
chr19_+_33793743 28.497 LOC80054
uncharacterized LOC80054
chr12_+_101988746 27.822 NM_002465
NM_206819
NM_206820
NM_206821
MYBPC1



myosin binding protein C, slow type



chr7_+_24323806 27.739 NM_000905
NPY
neuropeptide Y
chr7_+_75931829 27.536 NM_001540
HSPB1
heat shock 27kDa protein 1
chr16_-_15950850 27.340 NM_001040113
NM_001040114
NM_002474
NM_022844
MYH11



myosin, heavy chain 11, smooth muscle



chr17_-_61950997 27.067 NM_020991
NM_022644
NM_022645
CSH2


chorionic somatomammotropin hormone 2


chr12_-_11548485 27.056 NM_006248
PRB1
PRB2
proline-rich protein BstNI subfamily 1
proline-rich protein BstNI subfamily 2
chr9_-_104198045 26.828 NM_000035
ALDOB
aldolase B, fructose-bisphosphate
chr20_+_30193083 26.801 NM_002165
NM_181353
ID1

inhibitor of DNA binding 1, dominant negative helix-loop-helix protein

chr17_-_48278987 26.644 NM_000088
COL1A1
collagen, type I, alpha 1
chr17_-_61996135 26.573 NM_000515
NM_022559
NM_022560
NM_022561
NM_022562
GH1




growth hormone 1




chr16_-_56701904 26.238 NM_005950
MT1G
metallothionein 1G
chr12_-_52867521 25.948 NM_173086
KRT6C
keratin 6C
chr11_+_18287807 25.770 NM_000331
NM_001178006
NM_199161
SAA1


serum amyloid A1


chr11_+_1151578 25.613 MUC5AC
mucin 5AC, oligomeric mucus/gel-forming
chr5_+_78407603 25.449 NM_001713
BHMT
betaine--homocysteine S-methyltransferase
chr17_-_79818406 25.391 P4HB
prolyl 4-hydroxylase, beta polypeptide
chr2_-_21266809 25.286 APOB
apolipoprotein B (including Ag(x) antigen)
chr20_-_39317875 25.196 NM_005461
MAFB
v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)
chr1_-_182360889 24.907 GLUL
glutamate-ammonia ligase
chr9_+_117085302 24.846 NM_000607
ORM1
orosomucoid 1
chr20_+_31823801 24.834 NM_001243193
NM_016583
NM_130852
BPIFA1


BPI fold containing family A, member 1


chr7_+_116593354 24.738 NM_018412
NM_021908
ST7

suppression of tumorigenicity 7

chr21_-_43735705 24.656 NM_003226
TFF3
trefoil factor 3 (intestinal)
chr17_+_38599651 24.542 NM_001552
IGFBP4
insulin-like growth factor binding protein 4
chr1_-_20306093 24.514 NM_001161729
PLA2G2A
phospholipase A2, group IIA (platelets, synovial fluid)
chrX_-_106960268 23.830 NM_004089
TSC22D3
TSC22 domain family, member 3
chr1_-_203155867 23.778 CHI3L1
chitinase 3-like 1 (cartilage glycoprotein-39)
chr15_-_63673918 23.762 CA12
carbonic anhydrase XII
chr17_+_56315786 23.463 NM_001160102
NM_006151
LPO

lactoperoxidase

chr3_+_148545587 23.350 NM_001871
CPB1
carboxypeptidase B1 (tissue)
chrX_-_106960028 23.126 TSC22D3
TSC22 domain family, member 3
chr7_+_72742154 23.109 NM_001135211
NM_003602
FKBP6

FK506 binding protein 6, 36kDa

chr6_+_27100784 23.040 NM_021064
HIST1H2AG
histone cluster 1, H2ag
chr10_+_17851342 23.026 NM_002438
MRC1
mannose receptor, C type 1
chr20_-_43977023 23.024 NM_002999
SDC4
syndecan 4
chr1_-_203155813 22.732 CHI3L1
chitinase 3-like 1 (cartilage glycoprotein-39)
chr12_+_11081833 22.626 NM_005042
NM_001110213
PRH2

proline-rich protein HaeIII subfamily 2

chr4_+_25657434 22.541 NM_001177998
NM_006424
SLC34A2

solute carrier family 34 (sodium phosphate), member 2

chr12_-_11036815 22.305 NM_006250
PRH1
proline-rich protein HaeIII subfamily 1
chr2_-_179672056 22.238 NM_003319
NM_133378
NM_133379
NM_133432
NM_133437
TTN




titin




chr3_+_49449638 22.190 NM_022171
TCTA
T-cell leukemia translocation altered gene
chr2_-_21266915 21.904 NM_000384
APOB
apolipoprotein B (including Ag(x) antigen)
chr7_+_45927958 21.762 NM_000596
IGFBP1
insulin-like growth factor binding protein 1
chr10_+_17271277 21.741 VIM
vimentin
chr17_-_61988614 21.547 NM_001318
NM_022579
NM_022580
NM_022581
CSHL1



chorionic somatomammotropin hormone-like 1



chr10_+_17271276 21.446 VIM
vimentin
chr17_-_48546174 21.424 NM_001267
CHAD
chondroadherin
chr16_+_71392615 21.382 NM_001740
NM_007088
CALB2

calbindin 2

chr17_+_32683470 21.151 NM_005408
CCL13
chemokine (C-C motif) ligand 13
chr15_-_45670624 21.137 GATM
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr18_+_21718930 20.886 NM_012189
NM_138643
NM_153768
NM_153769
NM_153770
CABYR




calcium binding tyrosine-(Y)-phosphorylation regulated




chr4_+_71296208 20.872 NM_001145006
MUC7
mucin 7, secreted
chr1_+_37940180 20.828 ZC3H12A
zinc finger CCCH-type containing 12A
chr16_-_4292052 20.653 NM_001098814
SRL
sarcalumenin
chr15_-_51630735 20.553 NM_000103
NM_031226
CYP19A1

cytochrome P450, family 19, subfamily A, polypeptide 1

chr18_+_21719025 20.492 CABYR
calcium binding tyrosine-(Y)-phosphorylation regulated
chr14_-_103989195 20.311 NM_001823
CKB
creatine kinase, brain
chr19_+_10381763 20.078 ICAM1
intercellular adhesion molecule 1
chrX_+_46940235 19.984 RGN
regucalcin (senescence marker protein-30)
chr17_-_61973870 19.938 NM_001317
CSH1
chorionic somatomammotropin hormone 1 (placental lactogen)
chr6_+_33239798 19.904 NM_022551
RPS18
ribosomal protein S18
chr19_+_49468587 19.805 FTL
ferritin, light polypeptide
chr16_+_71392637 19.748 CALB2
calbindin 2
chr8_-_82395401 19.744 NM_001442
FABP4
fatty acid binding protein 4, adipocyte
chr17_+_32597239 19.717 NM_006273
CCL7
chemokine (C-C motif) ligand 7
chr14_+_93389491 19.677 CHGA
chromogranin A (parathyroid secretory protein 1)
chr13_+_53602829 19.551 NM_006418
OLFM4
olfactomedin 4
chr6_+_131894343 19.535 NM_000045
NM_001244438
ARG1

arginase, liver

chr4_+_74735107 19.513 NM_001511
CXCL1
chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
chr1_+_153963237 19.408 NM_001030
RPS27
ribosomal protein S27
chr8_+_133879202 19.355 NM_003235
TG
thyroglobulin
chr19_+_49468656 19.027 FTL
ferritin, light polypeptide
chr1_+_159557615 18.821 NM_001639
APCS
amyloid P component, serum
chr1_+_12916940 18.817 NM_023014
PRAMEF2
PRAME family member 2
chr1_+_152881022 18.685 NM_005547
IVL
involucrin
chr5_-_115152322 18.667 NM_001801
CDO1
cysteine dioxygenase, type I
chr18_+_56887389 18.482 NM_001012512
NM_001012513
NM_002091
GRP


gastrin-releasing peptide


chr8_+_19796840 18.377 LPL
lipoprotein lipase
chr8_+_24771276 18.348 NEFM
neurofilament, medium polypeptide
chr5_-_53606387 18.279 NM_019087
ARL15
ADP-ribosylation factor-like 15
chr7_-_45960738 18.127 NM_000598
NM_001013398
IGFBP3

insulin-like growth factor binding protein 3

chr1_+_12851545 18.076 NM_023013
PRAMEF1
PRAME family member 1
chr9_+_117092068 17.733 NM_000608
ORM2
orosomucoid 2
chr3_+_149192479 17.602 TM4SF4
transmembrane 4 L six family member 4
chr1_-_201465700 17.582 NM_001193572
CSRP1
cysteine and glycine-rich protein 1
chr1_+_86046434 17.524 NM_001554
CYR61
cysteine-rich, angiogenic inducer, 61
chr11_+_1074869 17.367 NM_002457
MUC2
mucin 2, oligomeric mucus/gel-forming
chr1_-_228613025 17.339 NM_003493
HIST3H3
histone cluster 3, H3
chr11_+_75273245 17.093 SERPINH1
serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
chr6_+_33239855 17.071 RPS18
ribosomal protein S18
chr2_-_163008913 16.838 NM_002054
GCG
glucagon
chr3_+_101546833 16.726 NM_001005474
NFKBIZ
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
chr11_+_62186506 16.673 NM_003357
SCGB1A1
secretoglobin, family 1A, member 1 (uteroglobin)
chr19_+_35773409 16.648 NM_021175
HAMP
hepcidin antimicrobial peptide
chr21_-_43735462 16.402 TFF3
trefoil factor 3 (intestinal)
chr6_-_27806116 16.396 NM_003510
HIST1H2AK
histone cluster 1, H2ak
chr21_-_43786602 16.377 NM_003225
TFF1
trefoil factor 1
chr17_-_39661803 16.323 NM_002274
NM_153490
KRT13

keratin 13

chr20_+_42086533 16.098 SRSF6
serine/arginine-rich splicing factor 6
chr3_+_52529351 16.079 NM_015136
STAB1
stabilin 1
chr14_+_65007418 16.058 HSPA2
heat shock 70kDa protein 2
chr19_+_49468557 16.048 NM_000146
FTL
ferritin, light polypeptide
chr15_+_39873276 15.903 NM_003246
THBS1
thrombospondin 1
chr19_+_12902295 15.843 NM_002229
JUNB
jun B proto-oncogene
chr3_+_133464883 15.693 NM_001063
TF
transferrin
chr6_+_27775898 15.633 NM_003509
HIST1H2AI
HIST1H2AM
HIST1H3F
histone cluster 1, H2ai
histone cluster 1, H2am
histone cluster 1, H3f
chr8_-_6735438 15.540 NM_005218
DEFB1
defensin, beta 1
chrX_+_84498993 15.473 NM_021998
ZNF711
zinc finger protein 711
chr19_+_859673 15.447 CFD
complement factor D (adipsin)
chr11_-_6462129 15.424 NM_000613
HPX
hemopexin
chr9_-_37034358 15.089 NM_016734
PAX5
paired box 5
chr12_-_92539614 15.043 NM_001731
BTG1
B-cell translocation gene 1, anti-proliferative
chr6_-_26250832 14.771 NM_021018
HIST1H3J
HIST1H3F
histone cluster 1, H3j
histone cluster 1, H3f
chr20_+_3052265 14.599 NM_000915
OXT
oxytocin, prepropeptide
chr16_+_202853 14.589 NM_005332
HBZ
hemoglobin, zeta
chr4_-_140098236 14.523


chr8_+_24771268 14.326 NM_005382
NEFM
neurofilament, medium polypeptide
chr17_-_39041436 14.321 NM_019010
KRT20
keratin 20
chr1_-_11714471 13.952 FBXO2
F-box protein 2
chr6_+_12290528 13.810 NM_001168319
NM_001955
EDN1

endothelin 1

chr1_-_27481400 13.788 NM_003047
SLC9A1
solute carrier family 9 (sodium/hydrogen exchanger), member 1
chr17_+_79008945 13.756 NM_001144888
NM_006340
NM_017450
NM_017451
BAIAP2



BAI1-associated protein 2



chr16_+_56691854 13.754 NM_005949
MT1F
metallothionein 1F
chr17_-_61959160 13.649 NM_002059
NM_022556
NM_022557
NM_022558
GH2



growth hormone 2




Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.44 4.99e-26 GO:0042221 response to chemical stimulus
2.24 2.11e-21 GO:0006950 response to stress
3.24 4.86e-17 GO:0006952 defense response
2.58 5.88e-15 GO:0010033 response to organic substance
4.98 7.92e-15 GO:0006954 inflammatory response
1.57 2.32e-14 GO:0032501 multicellular organismal process
2.20 2.36e-14 GO:0048513 organ development
4.86 1.22e-13 GO:0010035 response to inorganic substance
2.86 1.59e-13 GO:0009611 response to wounding
1.47 3.27e-13 GO:0050896 response to stimulus
1.69 1.28e-12 GO:0032502 developmental process
2.83 2.18e-12 GO:0009888 tissue development
2.01 3.87e-12 GO:0065008 regulation of biological quality
2.71 4.15e-12 GO:0070887 cellular response to chemical stimulus
8.07 4.39e-12 GO:0006334 nucleosome assembly
1.77 6.02e-12 GO:0048856 anatomical structure development
7.66 1.53e-11 GO:0031497 chromatin assembly
7.28 4.92e-11 GO:0034728 nucleosome organization
7.01 1.19e-10 GO:0065004 protein-DNA complex assembly
1.78 1.64e-10 GO:0048731 system development
3.29 3.52e-10 GO:0009607 response to biotic stimulus
4.46 4.10e-10 GO:0009617 response to bacterium
6.63 4.15e-10 GO:0071824 protein-DNA complex subunit organization
1.66 5.96e-10 GO:0007275 multicellular organismal development
6.10 8.51e-10 GO:0006323 DNA packaging
2.56 1.74e-09 GO:0051704 multi-organism process
3.49 1.95e-09 GO:0051707 response to other organism
2.24 2.17e-09 GO:0051239 regulation of multicellular organismal process
7.26 2.63e-09 GO:0000302 response to reactive oxygen species
2.92 5.55e-09 GO:0009725 response to hormone stimulus
3.32 5.77e-09 GO:0051094 positive regulation of developmental process
2.48 1.01e-08 GO:0050793 regulation of developmental process
10.76 1.88e-08 GO:0034614 cellular response to reactive oxygen species
5.50 2.50e-08 GO:0006333 chromatin assembly or disassembly
5.24 2.65e-08 GO:0071103 DNA conformation change
2.83 2.86e-08 GO:0048878 chemical homeostasis
8.61 2.88e-08 GO:0034599 cellular response to oxidative stress
2.71 5.09e-08 GO:0009719 response to endogenous stimulus
4.64 6.26e-08 GO:0006979 response to oxidative stress
2.44 6.77e-08 GO:0042592 homeostatic process
7.95 1.09e-07 GO:0042542 response to hydrogen peroxide
2.56 1.15e-07 GO:0006955 immune response
4.42 1.89e-07 GO:0008544 epidermis development
2.61 2.07e-07 GO:0002682 regulation of immune system process
2.31 2.72e-07 GO:0042127 regulation of cell proliferation
3.80 3.10e-07 GO:0048545 response to steroid hormone stimulus
12.69 4.19e-07 GO:0070301 cellular response to hydrogen peroxide
1.66 4.99e-07 GO:0048518 positive regulation of biological process
2.09 7.79e-07 GO:0002376 immune system process
8.37 8.32e-07 GO:0002526 acute inflammatory response
2.25 8.95e-07 GO:0009605 response to external stimulus
5.59 3.34e-06 GO:0008217 regulation of blood pressure
2.62 3.77e-06 GO:0009887 organ morphogenesis
3.85 3.95e-06 GO:0032101 regulation of response to external stimulus
2.38 7.34e-06 GO:2000026 regulation of multicellular organismal development
2.25 1.28e-05 GO:0040011 locomotion
2.26 1.45e-05 GO:0043933 macromolecular complex subunit organization
3.07 1.71e-05 GO:0034622 cellular macromolecular complex assembly
4.55 1.72e-05 GO:0002237 response to molecule of bacterial origin
2.74 2.42e-05 GO:0009628 response to abiotic stimulus
12.11 3.15e-05 GO:0042743 hydrogen peroxide metabolic process
2.57 3.58e-05 GO:0006928 cellular component movement
4.14 4.10e-05 GO:0010038 response to metal ion
1.24 4.70e-05 GO:0065007 biological regulation
3.07 5.06e-05 GO:0051240 positive regulation of multicellular organismal process
2.66 5.25e-05 GO:0034621 cellular macromolecular complex subunit organization
1.61 6.39e-05 GO:0048522 positive regulation of cellular process
3.32 8.96e-05 GO:0006875 cellular metal ion homeostasis
3.04 1.04e-04 GO:0045597 positive regulation of cell differentiation
1.41 1.45e-04 GO:0051716 cellular response to stimulus
1.81 1.54e-04 GO:0009653 anatomical structure morphogenesis
2.62 1.81e-04 GO:0072358 cardiovascular system development
2.62 1.81e-04 GO:0072359 circulatory system development
3.21 1.82e-04 GO:0055065 metal ion homeostasis
4.46 3.00e-04 GO:0051789 response to protein stimulus
5.05 3.15e-04 GO:0009266 response to temperature stimulus
2.24 3.83e-04 GO:0065003 macromolecular complex assembly
8.07 3.99e-04 GO:0072593 reactive oxygen species metabolic process
3.61 4.43e-04 GO:0003013 circulatory system process
3.61 4.43e-04 GO:0008015 blood circulation
4.07 5.48e-04 GO:0042445 hormone metabolic process
4.26 6.04e-04 GO:0032496 response to lipopolysaccharide
3.01 6.30e-04 GO:0030003 cellular cation homeostasis
7.69 6.57e-04 GO:0031424 keratinization
7.69 6.57e-04 GO:0045639 positive regulation of myeloid cell differentiation
12.56 9.92e-04 GO:0042744 hydrogen peroxide catabolic process
2.21 1.04e-03 GO:0045595 regulation of cell differentiation
2.85 1.11e-03 GO:0055080 cation homeostasis
4.57 1.19e-03 GO:0050727 regulation of inflammatory response
3.25 1.45e-03 GO:0008202 steroid metabolic process
2.53 1.49e-03 GO:0055082 cellular chemical homeostasis
3.03 1.61e-03 GO:0001817 regulation of cytokine production
2.35 1.66e-03 GO:0019725 cellular homeostasis
3.46 1.73e-03 GO:0010817 regulation of hormone levels
5.12 1.79e-03 GO:0045637 regulation of myeloid cell differentiation
1.54 1.83e-03 GO:0048519 negative regulation of biological process
3.57 1.98e-03 GO:0003012 muscle system process
7.86 2.12e-03 GO:0030049 muscle filament sliding
7.86 2.12e-03 GO:0033275 actin-myosin filament sliding
3.68 2.44e-03 GO:0006936 muscle contraction
20.18 2.47e-03 GO:0042738 exogenous drug catabolic process
6.73 2.49e-03 GO:0045766 positive regulation of angiogenesis
1.80 2.56e-03 GO:0009893 positive regulation of metabolic process
3.51 2.58e-03 GO:0030855 epithelial cell differentiation
7.65 2.71e-03 GO:0070252 actin-mediated cell contraction
2.55 2.77e-03 GO:0016477 cell migration
2.85 2.86e-03 GO:0034097 response to cytokine stimulus
13.84 3.44e-03 GO:0071347 cellular response to interleukin-1
2.35 3.45e-03 GO:0006935 chemotaxis
2.35 3.45e-03 GO:0042330 taxis
2.89 3.66e-03 GO:0040012 regulation of locomotion
5.24 3.68e-03 GO:0009913 epidermal cell differentiation
3.06 3.84e-03 GO:0051241 negative regulation of multicellular organismal process
1.87 3.87e-03 GO:0022607 cellular component assembly
2.61 4.08e-03 GO:0060429 epithelium development
2.46 4.14e-03 GO:0002684 positive regulation of immune system process
3.71 4.29e-03 GO:0050900 leukocyte migration
2.33 4.38e-03 GO:0008284 positive regulation of cell proliferation
6.33 4.48e-03 GO:0030048 actin filament-based movement
1.57 4.54e-03 GO:0030154 cell differentiation
4.72 4.66e-03 GO:0001818 negative regulation of cytokine production
2.85 4.75e-03 GO:0042493 response to drug
2.69 5.26e-03 GO:0043434 response to peptide hormone stimulus
2.06 5.35e-03 GO:0071844 cellular component assembly at cellular level
5.55 5.49e-03 GO:0030216 keratinocyte differentiation
2.74 6.07e-03 GO:0009991 response to extracellular stimulus
2.45 6.11e-03 GO:0006873 cellular ion homeostasis
2.40 6.83e-03 GO:0048870 cell motility
2.40 6.83e-03 GO:0051674 localization of cell
2.00 6.87e-03 GO:0048584 positive regulation of response to stimulus
2.94 7.69e-03 GO:0030334 regulation of cell migration
1.55 7.71e-03 GO:0048869 cellular developmental process
5.98 7.75e-03 GO:0051591 response to cAMP
2.68 8.69e-03 GO:0031347 regulation of defense response
4.47 8.71e-03 GO:0007586 digestion
7.83 8.78e-03 GO:0070555 response to interleukin-1
3.91 8.93e-03 GO:0031960 response to corticosteroid stimulus
1.11 8.94e-03 GO:0009987 cellular process
2.90 9.40e-03 GO:2000145 regulation of cell motility
4.42 9.83e-03 GO:0045765 regulation of angiogenesis
2.17 1.04e-02 GO:0042060 wound healing
16.15 1.06e-02 GO:0001542 ovulation from ovarian follicle
16.15 1.06e-02 GO:0042737 drug catabolic process
16.15 1.06e-02 GO:0045672 positive regulation of osteoclast differentiation
4.37 1.11e-02 GO:0032103 positive regulation of response to external stimulus
2.34 1.11e-02 GO:0050801 ion homeostasis
9.04 1.25e-02 GO:0002763 positive regulation of myeloid leukocyte differentiation
1.75 1.53e-02 GO:0031325 positive regulation of cellular metabolic process
2.72 1.66e-02 GO:0031667 response to nutrient levels
3.93 1.72e-02 GO:0051384 response to glucocorticoid stimulus
3.90 1.91e-02 GO:0042742 defense response to bacterium
5.38 2.08e-02 GO:0033500 carbohydrate homeostasis
5.38 2.08e-02 GO:0042593 glucose homeostasis
8.37 2.19e-02 GO:0031032 actomyosin structure organization
6.98 2.20e-02 GO:0006953 acute-phase response
3.62 2.33e-02 GO:0009410 response to xenobiotic stimulus
5.93 2.55e-02 GO:0055002 striated muscle cell development
1.73 2.61e-02 GO:0044085 cellular component biogenesis
4.74 2.69e-02 GO:0002576 platelet degranulation
1.74 2.70e-02 GO:0010604 positive regulation of macromolecule metabolic process
8.07 2.85e-02 GO:0032963 collagen metabolic process
3.33 3.37e-02 GO:0070482 response to oxygen levels
9.69 3.81e-02 GO:0045103 intermediate filament-based process
2.73 4.02e-02 GO:0001568 blood vessel development
2.64 4.14e-02 GO:0051270 regulation of cellular component movement
4.97 4.32e-02 GO:0019748 secondary metabolic process
7.54 4.65e-02 GO:0044259 multicellular organismal macromolecule metabolic process
4.12 4.66e-02 GO:0030198 extracellular matrix organization
6.30 4.90e-02 GO:0006721 terpenoid metabolic process
3.59 4.94e-02 GO:0043627 response to estrogen stimulus

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.95 2.13e-42 GO:0005576 extracellular region
4.64 1.35e-41 GO:0005615 extracellular space
4.00 2.03e-40 GO:0044421 extracellular region part
12.38 1.02e-17 GO:0000786 nucleosome
7.82 1.08e-12 GO:0032993 protein-DNA complex
5.54 4.75e-12 GO:0005882 intermediate filament
4.80 2.10e-10 GO:0045111 intermediate filament cytoskeleton
3.79 3.14e-07 GO:0000785 chromatin
3.55 3.44e-05 GO:0030141 stored secretory granule
6.83 7.08e-05 GO:0031983 vesicle lumen
2.69 1.09e-04 GO:0031012 extracellular matrix
12.56 1.14e-04 GO:0032982 myosin filament
4.20 1.85e-04 GO:0043292 contractile fiber
4.18 4.41e-04 GO:0030016 myofibril
4.73 1.28e-03 GO:0045095 keratin filament
4.00 1.61e-03 GO:0044449 contractile fiber part
1.43 2.09e-03 GO:0043228 non-membrane-bounded organelle
1.43 2.09e-03 GO:0043232 intracellular non-membrane-bounded organelle
10.76 2.21e-03 GO:0005859 muscle myosin complex
6.06 2.45e-03 GO:0034774 secretory granule lumen
5.81 3.47e-03 GO:0060205 cytoplasmic membrane-bounded vesicle lumen
13.46 3.63e-03 GO:0005833 hemoglobin complex
1.75 3.91e-03 GO:0044430 cytoskeletal part
9.69 4.38e-03 GO:0016460 myosin II complex
9.23 5.98e-03 GO:0001533 cornified envelope
1.57 7.17e-03 GO:0005856 cytoskeleton
2.13 1.39e-02 GO:0044427 chromosomal part
5.50 1.58e-02 GO:0031093 platelet alpha granule lumen
4.54 2.64e-02 GO:0016459 myosin complex
2.32 3.25e-02 GO:0005578 proteinaceous extracellular matrix

Gene overrepresentation in function category:

enrichment   p-value GO term description
3.65 4.29e-18 GO:0005198 structural molecule activity
2.81 2.25e-16 GO:0005102 receptor binding
8.81 2.29e-16 GO:0005179 hormone activity
5.16 6.78e-12 GO:0005125 cytokine activity
1.17 1.28e-10 GO:0005488 binding
5.92 2.99e-10 GO:0046906 tetrapyrrole binding
6.04 5.75e-10 GO:0020037 heme binding
4.37 8.12e-09 GO:0005506 iron ion binding
9.83 1.32e-08 GO:0008009 chemokine activity
4.49 5.46e-08 GO:0005126 cytokine receptor binding
8.87 6.22e-08 GO:0042379 chemokine receptor binding
9.33 1.39e-07 GO:0019825 oxygen binding
1.28 3.20e-07 GO:0005515 protein binding
4.32 6.36e-07 GO:0001664 G-protein-coupled receptor binding
5.65 3.28e-05 GO:0004497 monooxygenase activity
5.91 5.43e-05 GO:0005200 structural constituent of cytoskeleton
13.30 1.08e-04 GO:0005212 structural constituent of eye lens
7.51 1.44e-04 GO:0008307 structural constituent of muscle
2.66 2.06e-04 GO:0030246 carbohydrate binding
4.01 2.49e-04 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
14.90 3.49e-04 GO:0005344 oxygen transporter activity
4.37 3.75e-04 GO:0008201 heparin binding
3.66 4.62e-04 GO:0001871 pattern binding
3.66 4.62e-04 GO:0030247 polysaccharide binding
25.83 1.35e-03 GO:0046870 cadmium ion binding
9.42 1.60e-03 GO:0070330 aromatase activity
3.45 1.99e-03 GO:0008083 growth factor activity
8.70 2.88e-03 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
3.52 2.97e-03 GO:0005539 glycosaminoglycan binding
4.44 8.69e-03 GO:0005201 extracellular matrix structural constituent
11.53 1.31e-02 GO:0004089 carbonate dehydratase activity
5.87 1.45e-02 GO:0043498 cell surface binding
3.04 1.82e-02 GO:0009055 electron carrier activity
6.65 1.91e-02 GO:0004601 peroxidase activity
6.65 1.91e-02 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor
10.09 2.73e-02 GO:0008395 steroid hydroxylase activity
24.22 3.65e-02 GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor
24.22 3.65e-02 GO:0034875 caffeine oxidase activity
5.07 4.34e-02 GO:0016209 antioxidant activity