Motif ID: TCF4_dimer.p2

Z-value: 2.275


Transcription factors associated with TCF4_dimer.p2:

Gene SymbolEntrez IDGene Name
TCF4 6925 transcription factor 4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TCF4chr18_-_532553610.488.7e-14Click!


Activity profile for motif TCF4_dimer.p2.

activity profile for motif TCF4_dimer.p2


Sorted Z-values histogram for motif TCF4_dimer.p2

Sorted Z-values for motif TCF4_dimer.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TCF4_dimer.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_-_13956530 53.798 GPM6B
glycoprotein M6B
chr12_-_49392909 51.755 NM_015086
DDN
dendrin
chr3_-_195310985 51.495 NM_001647
APOD
apolipoprotein D
chr18_-_74691951 51.429 MBP
myelin basic protein
chrX_-_13956644 49.023 NM_001001994
GPM6B
glycoprotein M6B
chr1_+_1981902 43.194 NM_002744
PRKCZ
protein kinase C, zeta
chrX_-_13956445 40.238


chr17_+_38119225 39.974 NM_178171
GSDMA
gasdermin A
chr11_+_73358593 39.937 NM_001130034
NM_001130035
PLEKHB1

pleckstrin homology domain containing, family B (evectins) member 1

chr3_-_195310770 39.812 APOD
apolipoprotein D
chr22_+_41777932 38.633 NM_003216
TEF
thyrotrophic embryonic factor
chr5_+_173472692 36.860 NM_015980
HMP19
HMP19 protein
chr1_+_150255228 35.380 NM_144697
C1orf51
chromosome 1 open reading frame 51
chr7_-_124405029 33.203 GPR37
G protein-coupled receptor 37 (endothelin receptor type B-like)
chr14_-_23821423 30.012 NM_020372
SLC22A17
solute carrier family 22, member 17
chr19_+_36359346 29.897 NM_001024807
NM_005166
APLP1

amyloid beta (A4) precursor-like protein 1

chr22_-_19511777 29.371 CLDN5
claudin 5
chr7_-_22396511 28.705 NM_012294
RAPGEF5
Rap guanine nucleotide exchange factor (GEF) 5
chr6_-_136871542 28.473 MAP7
microtubule-associated protein 7
chr10_+_124220990 28.338 NM_002775
HTRA1
HtrA serine peptidase 1
chr19_+_18794487 28.255 CRTC1
CREB regulated transcription coactivator 1
chr15_-_76030958 28.069 DNM1P35
DNM1 pseudogene 35
chrX_+_110339374 28.062 NM_002578
PAK3
p21 protein (Cdc42/Rac)-activated kinase 3
chr14_+_100150596 27.926 NM_006668
CYP46A1
cytochrome P450, family 46, subfamily A, polypeptide 1
chr11_-_66725790 27.680 NM_000920
NM_001040716
PC

pyruvate carboxylase

chr5_+_140864626 26.974 NM_018928
NM_032406
PCDHGC4

protocadherin gamma subfamily C, 4

chr3_+_111717585 26.803 NM_001008272
NM_013259
TAGLN3

transgelin 3

chr9_+_17578952 26.529 NM_003026
SH3GL2
SH3-domain GRB2-like 2
chr17_+_40811261 25.344 NM_016437
TUBG2
tubulin, gamma 2
chrX_+_110187468 25.123 NM_001128166
NM_001128167
PAK3

p21 protein (Cdc42/Rac)-activated kinase 3

chr3_+_167453431 24.693 NM_001122752
NM_005025
SERPINI1

serpin peptidase inhibitor, clade I (neuroserpin), member 1

chr2_+_173600519 24.314 NM_007023
RAPGEF4
Rap guanine nucleotide exchange factor (GEF) 4
chr2_+_220283098 24.032 NM_001927
DES
desmin
chr4_+_113970784 23.711 NM_001148
NM_020977
ANK2

ankyrin 2, neuronal

chr15_+_75118950 23.634 NM_001030005
CPLX3
complexin 3
chr3_-_42305438 23.465 NM_001174138
CCK
cholecystokinin
chr19_-_6502224 23.253 NM_006087
TUBB4A
tubulin, beta 4A class IVa
chr5_+_113698304 23.196 KCNN2
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
chr12_-_109458844 22.988 NM_018711
SVOP
SV2 related protein homolog (rat)
chr1_-_144931707 22.841 PDE4DIP
phosphodiesterase 4D interacting protein
chr1_+_60280462 22.760 NM_015888
HOOK1
hook homolog 1 (Drosophila)
chr21_-_42219038 22.610 NM_001389
DSCAM
Down syndrome cell adhesion molecule
chr15_+_44580954 22.378 CASC4
cancer susceptibility candidate 4
chr9_-_93405066 22.323 NM_017594
DIRAS2
DIRAS family, GTP-binding RAS-like 2
chr11_+_118401873 22.176 TMEM25
transmembrane protein 25
chrX_-_13835187 22.095 GPM6B
glycoprotein M6B
chr2_+_79740059 21.723 NM_001164883
NM_004389
CTNNA2

catenin (cadherin-associated protein), alpha 2

chr20_-_590909 21.632 NM_004609
TCF15
transcription factor 15 (basic helix-loop-helix)
chr8_-_110657025 21.421 NM_001099753
NM_001099754
NM_001099755
SYBU


syntabulin (syntaxin-interacting)


chr1_-_233431458 21.189 NM_014801
PCNXL2
pecanex-like 2 (Drosophila)
chr20_+_42839599 21.105 LOC100505783
uncharacterized LOC100505783
chr3_-_195306274 21.079 APOD
apolipoprotein D
chr1_+_2005424 20.786 NM_001242874
PRKCZ
protein kinase C, zeta
chr6_+_31783314 20.774 HSPA1A
HSPA1B
heat shock 70kDa protein 1A
heat shock 70kDa protein 1B
chr3_+_32148136 20.500 GPD1L
glycerol-3-phosphate dehydrogenase 1-like
chr10_-_135150368 20.333 CALY
calcyon neuron-specific vesicular protein
chr5_+_173472737 20.212 HMP19
HMP19 protein
chr4_-_176923533 20.140 GPM6A
glycoprotein M6A
chr5_+_113698015 19.637 NM_021614
KCNN2
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
chr1_+_65720091 19.632 LOC645195
DNAJC6
uncharacterized LOC645195
DnaJ (Hsp40) homolog, subfamily C, member 6
chr4_+_41258941 19.488 UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr12_-_16759430 19.457 LMO3
LIM domain only 3 (rhombotin-like 2)
chr4_-_176923480 19.362 GPM6A
glycoprotein M6A
chr3_+_35681008 19.215 ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr6_-_62995852 19.070 NM_152688
KHDRBS2
KH domain containing, RNA binding, signal transduction associated 2
chr2_+_173600634 19.043 RAPGEF4
Rap guanine nucleotide exchange factor (GEF) 4
chr5_-_1295022 19.013 NM_001193376
NM_198253
TERT

telomerase reverse transcriptase

chr1_-_17445865 18.921 NM_007365
PADI2
peptidyl arginine deiminase, type II
chr4_-_57976550 18.894 NM_001253835
NM_001553
IGFBP7

insulin-like growth factor binding protein 7

chr19_+_14017038 18.871 CC2D1A
coiled-coil and C2 domain containing 1A
chrX_+_70443055 18.845 NM_000166
GJB1
gap junction protein, beta 1, 32kDa
chr4_-_176923572 18.828 NM_005277
NM_201592
GPM6A

glycoprotein M6A

chr19_+_54058493 18.644 NM_001079907
ZNF331
zinc finger protein 331
chr11_+_62475165 18.624 GNG3
guanine nucleotide binding protein (G protein), gamma 3
chr4_-_57976516 18.602 IGFBP7
insulin-like growth factor binding protein 7
chr19_-_18632857 18.590 ELL
elongation factor RNA polymerase II
chr10_-_135150474 18.560 NM_015722
CALY
calcyon neuron-specific vesicular protein
chr12_-_16759531 18.444 NM_018640
LMO3
LIM domain only 3 (rhombotin-like 2)
chr11_+_113931228 18.434 NM_001018011
ZBTB16
zinc finger and BTB domain containing 16
chr13_+_35516390 18.405 NM_015678
NBEA
neurobeachin
chr2_+_46524448 18.394 NM_001430
EPAS1
endothelial PAS domain protein 1
chr16_+_330605 18.336 NM_001176
ARHGDIG
Rho GDP dissociation inhibitor (GDI) gamma
chr3_+_50712671 17.955 NM_004947
DOCK3
dedicator of cytokinesis 3
chr1_+_203097427 17.874 ADORA1
adenosine A1 receptor
chr17_+_1665233 17.752 NM_002615
SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr2_-_224702200 17.719 AP1S3
adaptor-related protein complex 1, sigma 3 subunit
chr19_+_5904842 17.671 NM_001017921
VMAC
vimentin-type intermediate filament associated coiled-coil protein
chr15_-_75660944 17.664 MAN2C1
mannosidase, alpha, class 2C, member 1
chr2_+_17721806 17.631 NM_003385
VSNL1
visinin-like 1
chr17_+_1665281 17.533 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr15_+_74833517 17.360 NM_006465
ARID3B
AT rich interactive domain 3B (BRIGHT-like)
chr6_+_72892371 17.329 RIMS1
regulating synaptic membrane exocytosis 1
chr2_-_68384575 17.282 NM_138458
WDR92
WD repeat domain 92
chr6_+_31783530 17.176 HSPA1A
HSPA1B
heat shock 70kDa protein 1A
heat shock 70kDa protein 1B
chr17_+_47653474 17.166 NXPH3
neurexophilin 3
chrX_-_13835012 17.154 GPM6B
glycoprotein M6B
chr17_+_42385780 17.091 NM_001144825
NM_001144826
NM_006695
RUNDC3A


RUN domain containing 3A


chr12_-_16758839 16.996 NM_001243612
LMO3
LIM domain only 3 (rhombotin-like 2)
chr4_-_140005344 16.885 ELF2
E74-like factor 2 (ets domain transcription factor)
chr22_-_31741565 16.772 PATZ1
POZ (BTB) and AT hook containing zinc finger 1
chr10_-_21462987 16.671 NEBL
nebulette
chr6_-_46459010 16.649 NM_001251974
RCAN2
regulator of calcineurin 2
chr20_-_3149070 16.633 NM_014731
ProSAPiP1
ProSAPiP1 protein
chr11_+_113930430 16.621 NM_006006
ZBTB16
zinc finger and BTB domain containing 16
chrX_-_50557019 16.601 NM_020717
SHROOM4
shroom family member 4
chr19_-_10341947 16.472 NM_004230
S1PR2
sphingosine-1-phosphate receptor 2
chr6_-_84418705 16.457 NM_001242792
SNAP91
synaptosomal-associated protein, 91kDa homolog (mouse)
chr20_+_44657812 16.396 NM_020708
SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5
chr6_+_111303240 16.386 NM_032194
RPF2
ribosome production factor 2 homolog (S. cerevisiae)
chr17_-_7123368 16.356 NM_001365
DLG4
discs, large homolog 4 (Drosophila)
chr20_+_44657858 16.334 SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5
chrX_-_13835213 16.328 GPM6B
glycoprotein M6B
chr2_+_17721983 16.192 VSNL1
visinin-like 1
chr6_-_136871956 16.135 NM_001198616
NM_001198617
NM_003980
MAP7


microtubule-associated protein 7


chr15_-_83316621 16.026 NM_030594
CPEB1
cytoplasmic polyadenylation element binding protein 1
chr8_+_136470108 15.980 KHDRBS3
KH domain containing, RNA binding, signal transduction associated 3
chr3_+_111718006 15.933 NM_001008273
TAGLN3
transgelin 3
chr11_+_6280903 15.779 NM_176875
CCKBR
cholecystokinin B receptor
chr22_+_22712091 15.777 IGLV1-44
IGL@
immunoglobulin lambda variable 1-44
immunoglobulin lambda locus
chr2_+_233562042 15.560 GIGYF2
GRB10 interacting GYF protein 2
chr9_-_91793375 15.557 SHC3
SHC (Src homology 2 domain containing) transforming protein 3
chr17_+_1665306 15.539 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr8_-_22089517 15.523 PHYHIP
phytanoyl-CoA 2-hydroxylase interacting protein
chr10_-_11653529 15.486 NM_014688
USP6NL
USP6 N-terminal like
chr9_+_6757636 15.455 NM_001146694
NM_001146695
NM_015061
KDM4C


lysine (K)-specific demethylase 4C


chr9_-_35689902 15.405 NM_003289
NM_213674
TPM2

tropomyosin 2 (beta)

chr1_+_206224282 15.369 NM_000707
AVPR1B
arginine vasopressin receptor 1B
chr2_+_173600595 15.317 RAPGEF4
Rap guanine nucleotide exchange factor (GEF) 4
chr16_-_4322695 15.316 TFAP4
transcription factor AP-4 (activating enhancer binding protein 4)
chr7_-_767286 15.220 NM_001164758
NM_001164759
PRKAR1B

protein kinase, cAMP-dependent, regulatory, type I, beta

chr1_-_182361311 15.191 NM_001033044
NM_002065
GLUL

glutamate-ammonia ligase

chr2_-_89292396 15.181 IGKC
immunoglobulin kappa constant
chr19_-_36523540 15.155 NM_001199570
CLIP3
CAP-GLY domain containing linker protein 3
chr19_-_12886263 15.145 HOOK2
hook homolog 2 (Drosophila)
chr1_-_52831817 15.135 NM_032449
CC2D1B
coiled-coil and C2 domain containing 1B
chr17_+_47653176 15.130 NM_007225
NXPH3
neurexophilin 3
chr4_-_57522469 15.121 NM_001145459
NM_139211
HOPX

HOP homeobox

chr17_+_53342356 15.117 HLF
hepatic leukemia factor
chr10_+_99258615 15.081 NM_024954
UBTD1
ubiquitin domain containing 1
chr12_+_79258517 15.078 SYT1
synaptotagmin I
chr12_+_122459791 15.067 NM_001024808
NM_020993
BCL7A

B-cell CLL/lymphoma 7A

chr6_-_39197225 15.054 NM_003740
KCNK5
potassium channel, subfamily K, member 5
chr19_+_35773409 15.022 NM_021175
HAMP
hepcidin antimicrobial peptide
chr14_-_64970319 15.021 NM_006977
ZBTB25
zinc finger and BTB domain containing 25
chrX_+_103031797 15.017 PLP1
proteolipid protein 1
chr19_+_54042041 14.923 NM_001253800
ZNF331
zinc finger protein 331
chr5_-_178772328 14.918 ADAMTS2
ADAM metallopeptidase with thrombospondin type 1 motif, 2
chr4_-_57976355 14.918 IGFBP7
insulin-like growth factor binding protein 7
chr22_-_38379868 14.908 SOX10
SRY (sex determining region Y)-box 10
chr7_-_79082870 14.893 NM_012301
MAGI2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr8_-_144241456 14.843 NM_002347
LY6H
lymphocyte antigen 6 complex, locus H
chr10_-_62149487 14.835 NM_020987
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr18_-_5630629 14.800 EPB41L3
erythrocyte membrane protein band 4.1-like 3
chr7_-_8301767 14.799 NM_001136020
ICA1
islet cell autoantigen 1, 69kDa
chr13_+_48877950 14.751 RB1
retinoblastoma 1
chr10_-_21463019 14.747 NM_001173484
NM_213569
NEBL

nebulette

chr5_+_156693051 14.736 NM_001037333
NM_001037332
CYFIP2

cytoplasmic FMR1 interacting protein 2

chr10_-_102988688 14.612 NM_006562
LBX1
ladybird homeobox 1
chr11_-_125366048 14.586 NM_005103
NM_022549
FEZ1

fasciculation and elongation protein zeta 1 (zygin I)

chr17_-_29624249 14.583 NM_002544
OMG
oligodendrocyte myelin glycoprotein
chr19_-_49658645 14.577 NM_002152
HRC
histidine rich calcium binding protein
chr5_+_55033844 14.569 NM_001142549
NM_001166533
NM_024415
DDX4


DEAD (Asp-Glu-Ala-Asp) box polypeptide 4


chr13_-_28674646 14.550 NM_004119
FLT3
fms-related tyrosine kinase 3
chr11_-_695010 14.532 DEAF1
deformed epidermal autoregulatory factor 1 (Drosophila)
chr19_-_18632886 14.517 NM_006532
ELL
elongation factor RNA polymerase II
chr8_+_38034066 14.495 NM_001204878
NM_004874
BAG4

BCL2-associated athanogene 4

chr17_-_7197811 14.478 YBX2
Y box binding protein 2
chr21_-_42218587 14.458 DSCAM
Down syndrome cell adhesion molecule
chr19_-_46974663 14.451 PNMAL1
PNMA-like 1
chr14_+_69865380 14.439 NM_001252148
NM_001252150
NM_018375
SLC39A9


solute carrier family 39 (zinc transporter), member 9


chr20_+_1246959 14.409 NM_014723
SNPH
syntaphilin
chr2_+_46524901 14.354 EPAS1
endothelial PAS domain protein 1
chr16_-_57318574 14.335 NM_015993
PLLP
plasmolipin
chr11_+_125774271 14.204 NM_013264
DDX25
DEAD (Asp-Glu-Ala-Asp) box polypeptide 25
chr8_-_127570465 14.201 FAM84B
family with sequence similarity 84, member B
chr2_+_203499819 14.152 NM_173511
FAM117B
family with sequence similarity 117, member B
chr19_+_35782988 14.127 NM_001199216
NM_002361
NM_080600
MAG


myelin associated glycoprotein


chr10_+_105037441 14.055 INA
internexin neuronal intermediate filament protein, alpha
chr3_+_52444673 13.990 PHF7
PHD finger protein 7
chr7_+_94023872 13.913 NM_000089
COL1A2
collagen, type I, alpha 2
chr22_+_22735207 13.899 IGLJ3
immunoglobulin lambda joining 3
chr11_-_33890931 13.887 LMO2
LIM domain only 2 (rhombotin-like 1)
chr11_+_12132063 13.878 NM_014632
MICAL2
microtubule associated monoxygenase, calponin and LIM domain containing 2
chr17_-_79139871 13.877 NM_001080395
AATK
apoptosis-associated tyrosine kinase
chr17_-_7197896 13.853 YBX2
Y box binding protein 2
chr19_+_19322763 13.840 NM_004386
NCAN
neurocan
chr7_-_3083346 13.781 NM_032415
CARD11
caspase recruitment domain family, member 11
chr6_+_89855745 13.763 NM_001010853
PM20D2
peptidase M20 domain containing 2
chr7_-_143059144 13.753 NM_014690
FAM131B
family with sequence similarity 131, member B
chr6_-_46293404 13.746 RCAN2
regulator of calcineurin 2
chr1_-_182360889 13.692 GLUL
glutamate-ammonia ligase
chr6_+_87865261 13.664 NM_015021
ZNF292
zinc finger protein 292
chr11_+_62475113 13.575 NM_012202
GNG3
guanine nucleotide binding protein (G protein), gamma 3
chr12_+_79258588 13.564 SYT1
synaptotagmin I
chr16_+_69796237 13.531 NM_007014
NM_199423
WWP2

WW domain containing E3 ubiquitin protein ligase 2

chr19_+_41107220 13.523 NM_001042545
LTBP4
latent transforming growth factor beta binding protein 4
chr19_+_40973049 13.512 NM_020971
SPTBN4
spectrin, beta, non-erythrocytic 4
chr11_-_45307617 13.508 NM_001247987
NM_020826
SYT13

synaptotagmin XIII

chr14_+_69865095 13.478 NM_001252151
NM_001252152
SLC39A9

solute carrier family 39 (zinc transporter), member 9

chr17_+_5972425 13.431 WSCD1
WSC domain containing 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.42 1.82e-38 GO:0048856 anatomical structure development
1.44 2.71e-36 GO:0048731 system development
1.35 3.89e-33 GO:0032502 developmental process
1.37 1.08e-32 GO:0007275 multicellular organismal development
1.27 1.89e-31 GO:0032501 multicellular organismal process
1.20 3.97e-31 GO:0065007 biological regulation
1.33 4.40e-29 GO:0023052 signaling
1.54 3.11e-25 GO:0007399 nervous system development
1.11 1.29e-24 GO:0009987 cellular process
1.18 8.40e-24 GO:0050789 regulation of biological process
1.44 2.94e-22 GO:0048513 organ development
1.18 7.59e-22 GO:0050794 regulation of cellular process
1.71 7.11e-21 GO:0007267 cell-cell signaling
1.41 1.39e-20 GO:0030154 cell differentiation
1.39 5.59e-20 GO:0048869 cellular developmental process
1.52 1.19e-19 GO:0051239 regulation of multicellular organismal process
1.29 8.03e-19 GO:0007165 signal transduction
1.47 8.19e-19 GO:0009653 anatomical structure morphogenesis
1.37 1.51e-17 GO:0065008 regulation of biological quality
1.56 1.82e-17 GO:0007154 cell communication
1.24 3.25e-17 GO:0051716 cellular response to stimulus
1.80 2.40e-16 GO:0019226 transmission of nerve impulse
1.80 2.40e-16 GO:0035637 multicellular organismal signaling
1.57 2.66e-16 GO:0048468 cell development
1.34 2.71e-16 GO:0042221 response to chemical stimulus
1.17 8.81e-16 GO:0050896 response to stimulus
1.38 2.81e-15 GO:0007166 cell surface receptor linked signaling pathway
1.80 1.67e-14 GO:0007268 synaptic transmission
1.52 2.05e-13 GO:0022008 neurogenesis
1.54 3.35e-13 GO:0048699 generation of neurons
1.65 3.39e-13 GO:0009887 organ morphogenesis
1.60 3.53e-13 GO:0030182 neuron differentiation
1.51 1.40e-12 GO:0050793 regulation of developmental process
1.56 3.97e-12 GO:2000026 regulation of multicellular organismal development
1.63 1.24e-11 GO:0048666 neuron development
2.14 1.41e-11 GO:0003012 muscle system process
2.17 3.54e-11 GO:0006936 muscle contraction
1.80 1.41e-10 GO:0044057 regulation of system process
1.34 2.64e-10 GO:0023051 regulation of signaling
1.25 4.20e-10 GO:0048518 positive regulation of biological process
1.47 8.72e-10 GO:0040011 locomotion
1.21 1.66e-09 GO:0051179 localization
1.43 2.56e-09 GO:0032879 regulation of localization
1.77 5.18e-09 GO:0007610 behavior
1.60 7.84e-09 GO:0007417 central nervous system development
1.28 3.95e-08 GO:0048583 regulation of response to stimulus
1.32 5.10e-08 GO:0065009 regulation of molecular function
1.24 1.64e-07 GO:0048522 positive regulation of cellular process
1.56 1.81e-07 GO:0000904 cell morphogenesis involved in differentiation
1.50 2.13e-07 GO:0048878 chemical homeostasis
1.41 2.13e-07 GO:0006811 ion transport
1.60 2.16e-07 GO:0048667 cell morphogenesis involved in neuron differentiation
1.59 2.35e-07 GO:0051094 positive regulation of developmental process
1.52 3.66e-07 GO:0007186 G-protein coupled receptor protein signaling pathway
1.48 5.95e-07 GO:0032989 cellular component morphogenesis
1.59 6.88e-07 GO:0007409 axonogenesis
1.46 7.49e-07 GO:0045595 regulation of cell differentiation
1.36 7.97e-07 GO:0010646 regulation of cell communication
1.34 8.53e-07 GO:0050790 regulation of catalytic activity
1.70 9.15e-07 GO:0019932 second-messenger-mediated signaling
1.57 9.88e-07 GO:0048812 neuron projection morphogenesis
1.17 1.07e-06 GO:0019222 regulation of metabolic process
1.23 1.12e-06 GO:0048519 negative regulation of biological process
1.47 1.34e-06 GO:0030030 cell projection organization
1.24 1.60e-06 GO:0048523 negative regulation of cellular process
1.55 1.66e-06 GO:0050801 ion homeostasis
1.51 2.94e-06 GO:0006935 chemotaxis
1.51 2.94e-06 GO:0042330 taxis
1.39 3.48e-06 GO:0009888 tissue development
1.66 4.17e-06 GO:0022603 regulation of anatomical structure morphogenesis
1.65 4.84e-06 GO:0001501 skeletal system development
1.36 5.35e-06 GO:0009605 response to external stimulus
1.55 5.76e-06 GO:0006873 cellular ion homeostasis
1.53 5.79e-06 GO:0072358 cardiovascular system development
1.53 5.79e-06 GO:0072359 circulatory system development
1.51 6.42e-06 GO:0031175 neuron projection development
2.17 6.96e-06 GO:0045761 regulation of adenylate cyclase activity
1.54 6.98e-06 GO:0055082 cellular chemical homeostasis
1.36 7.09e-06 GO:0042127 regulation of cell proliferation
1.29 7.45e-06 GO:0009966 regulation of signal transduction
1.98 8.59e-06 GO:0007187 G-protein signaling, coupled to cyclic nucleotide second messenger
1.68 8.73e-06 GO:0007423 sensory organ development
1.62 8.86e-06 GO:0007411 axon guidance
1.40 1.02e-05 GO:0007155 cell adhesion
1.40 1.02e-05 GO:0022610 biological adhesion
1.26 1.15e-05 GO:0003008 system process
1.64 1.46e-05 GO:0006140 regulation of nucleotide metabolic process
1.92 1.59e-05 GO:0019935 cyclic-nucleotide-mediated signaling
2.13 1.78e-05 GO:0031279 regulation of cyclase activity
2.01 1.88e-05 GO:0030802 regulation of cyclic nucleotide biosynthetic process
2.01 1.88e-05 GO:0030808 regulation of nucleotide biosynthetic process
1.99 2.04e-05 GO:0030799 regulation of cyclic nucleotide metabolic process
1.45 2.36e-05 GO:0000902 cell morphogenesis
1.78 2.97e-05 GO:0003013 circulatory system process
1.78 2.97e-05 GO:0008015 blood circulation
1.29 3.09e-05 GO:0035556 intracellular signal transduction
1.96 3.23e-05 GO:0042391 regulation of membrane potential
1.46 3.45e-05 GO:0051336 regulation of hydrolase activity
1.18 3.55e-05 GO:0006810 transport
2.04 3.99e-05 GO:0019933 cAMP-mediated signaling
1.18 4.05e-05 GO:0051234 establishment of localization
1.34 4.28e-05 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.42 4.29e-05 GO:0007167 enzyme linked receptor protein signaling pathway
2.09 4.37e-05 GO:0051339 regulation of lyase activity
2.03 4.41e-05 GO:0030817 regulation of cAMP biosynthetic process
2.09 5.99e-05 GO:0007188 G-protein signaling, coupled to cAMP nucleotide second messenger
2.01 6.61e-05 GO:0030814 regulation of cAMP metabolic process
2.01 6.61e-05 GO:0050804 regulation of synaptic transmission
1.37 6.66e-05 GO:0055085 transmembrane transport
1.39 6.71e-05 GO:0051049 regulation of transport
1.47 9.16e-05 GO:0048858 cell projection morphogenesis
1.58 9.49e-05 GO:0045597 positive regulation of cell differentiation
1.47 1.02e-04 GO:0032990 cell part morphogenesis
1.40 1.47e-04 GO:0010628 positive regulation of gene expression
2.76 1.82e-04 GO:0006941 striated muscle contraction
1.15 1.84e-04 GO:0080090 regulation of primary metabolic process
1.90 1.91e-04 GO:0060191 regulation of lipase activity
2.04 1.93e-04 GO:0007202 activation of phospholipase C activity
1.48 2.41e-04 GO:0048870 cell motility
1.48 2.41e-04 GO:0051674 localization of cell
1.91 2.49e-04 GO:0051969 regulation of transmission of nerve impulse
1.97 2.71e-04 GO:0060193 positive regulation of lipase activity
2.02 2.92e-04 GO:0010863 positive regulation of phospholipase C activity
2.15 3.00e-04 GO:0008016 regulation of heart contraction
1.61 3.16e-04 GO:0061061 muscle structure development
1.53 3.60e-04 GO:0007420 brain development
1.33 3.85e-04 GO:0042592 homeostatic process
1.46 4.00e-04 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.33 4.47e-04 GO:0009611 response to wounding
1.18 4.73e-04 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.98 4.74e-04 GO:0010518 positive regulation of phospholipase activity
1.38 4.87e-04 GO:0009719 response to endogenous stimulus
1.48 6.31e-04 GO:0016477 cell migration
1.71 7.10e-04 GO:0007517 muscle organ development
1.54 1.02e-03 GO:0051093 negative regulation of developmental process
1.82 1.04e-03 GO:0031644 regulation of neurological system process
1.93 1.07e-03 GO:0010517 regulation of phospholipase activity
1.26 1.08e-03 GO:0010033 response to organic substance
1.43 1.26e-03 GO:0001775 cell activation
1.14 1.37e-03 GO:0031323 regulation of cellular metabolic process
1.30 1.52e-03 GO:0070887 cellular response to chemical stimulus
1.41 1.55e-03 GO:0019725 cellular homeostasis
1.40 1.83e-03 GO:0006928 cellular component movement
1.34 1.90e-03 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
2.45 2.01e-03 GO:0007422 peripheral nervous system development
2.07 2.18e-03 GO:0048706 embryonic skeletal system development
2.58 2.31e-03 GO:0070252 actin-mediated cell contraction
1.76 2.58e-03 GO:0048562 embryonic organ morphogenesis
1.32 2.65e-03 GO:0044093 positive regulation of molecular function
1.41 2.79e-03 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.26 3.01e-03 GO:0002376 immune system process
2.26 3.45e-03 GO:0007194 negative regulation of adenylate cyclase activity
2.26 3.45e-03 GO:0031280 negative regulation of cyclase activity
2.26 3.45e-03 GO:0051350 negative regulation of lyase activity
1.16 3.78e-03 GO:0051171 regulation of nitrogen compound metabolic process
1.37 4.18e-03 GO:0009725 response to hormone stimulus
1.34 4.30e-03 GO:0043085 positive regulation of catalytic activity
1.32 4.34e-03 GO:0051173 positive regulation of nitrogen compound metabolic process
1.80 4.71e-03 GO:0001503 ossification
1.36 5.46e-03 GO:0045893 positive regulation of transcription, DNA-dependent
1.87 5.76e-03 GO:0007611 learning or memory
2.54 6.03e-03 GO:0030049 muscle filament sliding
2.54 6.03e-03 GO:0033275 actin-myosin filament sliding
1.80 6.37e-03 GO:0048705 skeletal system morphogenesis
1.44 6.86e-03 GO:0040008 regulation of growth
1.43 7.55e-03 GO:0008285 negative regulation of cell proliferation
1.88 7.60e-03 GO:0006836 neurotransmitter transport
1.37 8.10e-03 GO:0006812 cation transport
1.14 8.38e-03 GO:0016043 cellular component organization
1.82 8.48e-03 GO:0050890 cognition
1.53 8.66e-03 GO:0051345 positive regulation of hydrolase activity
1.50 9.17e-03 GO:0051046 regulation of secretion
1.58 9.17e-03 GO:0007507 heart development
1.58 9.61e-03 GO:0030168 platelet activation
1.16 1.00e-02 GO:0031326 regulation of cellular biosynthetic process
1.47 1.10e-02 GO:0051240 positive regulation of multicellular organismal process
2.38 1.22e-02 GO:0007193 inhibition of adenylate cyclase activity by G-protein signaling pathway
2.24 1.47e-02 GO:0030048 actin filament-based movement
1.57 1.55e-02 GO:0048568 embryonic organ development
1.15 1.61e-02 GO:0009889 regulation of biosynthetic process
1.41 1.64e-02 GO:0060341 regulation of cellular localization
1.63 1.69e-02 GO:0048732 gland development
1.50 1.86e-02 GO:0051270 regulation of cellular component movement
1.47 1.98e-02 GO:0032535 regulation of cellular component size
1.41 2.08e-02 GO:0032583 regulation of gene-specific transcription
2.15 2.11e-02 GO:0034339 regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor
1.53 2.55e-02 GO:0008361 regulation of cell size
1.32 2.68e-02 GO:0051254 positive regulation of RNA metabolic process
2.08 2.76e-02 GO:0001508 regulation of action potential
1.50 2.85e-02 GO:0040012 regulation of locomotion
1.43 2.87e-02 GO:0090066 regulation of anatomical structure size
1.40 3.18e-02 GO:0071702 organic substance transport
1.60 3.21e-02 GO:0010817 regulation of hormone levels
1.81 3.83e-02 GO:0008217 regulation of blood pressure
1.16 3.90e-02 GO:0006950 response to stress
3.01 4.21e-02 GO:0042551 neuron maturation
1.37 4.23e-02 GO:0048585 negative regulation of response to stimulus
1.22 4.37e-02 GO:0009893 positive regulation of metabolic process
1.46 4.50e-02 GO:0060284 regulation of cell development
1.37 4.51e-02 GO:0030001 metal ion transport
1.32 4.59e-02 GO:0001932 regulation of protein phosphorylation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.44 4.63e-29 GO:0044459 plasma membrane part
1.53 3.46e-22 GO:0031226 intrinsic to plasma membrane
1.53 8.65e-22 GO:0005887 integral to plasma membrane
1.20 5.91e-13 GO:0005886 plasma membrane
1.20 2.72e-12 GO:0071944 cell periphery
1.48 1.03e-10 GO:0005615 extracellular space
1.46 2.29e-10 GO:0005626 insoluble fraction
1.41 2.39e-10 GO:0044421 extracellular region part
1.45 1.02e-09 GO:0005624 membrane fraction
1.34 1.20e-07 GO:0000267 cell fraction
1.48 1.22e-07 GO:0030054 cell junction
1.58 1.78e-07 GO:0045202 synapse
1.56 9.54e-07 GO:0043005 neuron projection
1.22 4.36e-06 GO:0005576 extracellular region
1.80 7.22e-06 GO:0044297 cell body
1.80 9.69e-06 GO:0043025 neuronal cell body
1.34 1.11e-05 GO:0042995 cell projection
1.08 1.60e-05 GO:0005737 cytoplasm
1.64 6.27e-05 GO:0016323 basolateral plasma membrane
1.89 6.52e-05 GO:0043292 contractile fiber
1.48 1.85e-04 GO:0031012 extracellular matrix
1.32 2.44e-04 GO:0031982 vesicle
1.87 3.17e-04 GO:0030016 myofibril
1.33 3.44e-04 GO:0031988 membrane-bounded vesicle
1.63 3.64e-04 GO:0034702 ion channel complex
1.65 5.93e-04 GO:0030425 dendrite
1.32 6.29e-04 GO:0031410 cytoplasmic vesicle
1.67 6.72e-04 GO:0030424 axon
1.32 9.29e-04 GO:0016023 cytoplasmic membrane-bounded vesicle
1.07 1.75e-03 GO:0016020 membrane
1.47 1.99e-03 GO:0044433 cytoplasmic vesicle part
1.48 3.84e-03 GO:0044456 synapse part
1.77 5.21e-03 GO:0044449 contractile fiber part
2.38 9.76e-03 GO:0005581 collagen
1.54 1.47e-02 GO:0005911 cell-cell junction
1.45 1.87e-02 GO:0012506 vesicle membrane
1.75 3.14e-02 GO:0030017 sarcomere
2.37 4.35e-02 GO:0043204 perikaryon
1.35 4.40e-02 GO:0044463 cell projection part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.14 1.21e-13 GO:0005515 protein binding
1.07 1.21e-11 GO:0005488 binding
1.42 2.67e-10 GO:0005102 receptor binding
1.46 1.05e-07 GO:0043565 sequence-specific DNA binding
1.37 1.08e-07 GO:0001071 nucleic acid binding transcription factor activity
1.37 1.08e-07 GO:0003700 sequence-specific DNA binding transcription factor activity
1.38 1.41e-07 GO:0022857 transmembrane transporter activity
1.32 8.03e-07 GO:0005215 transporter activity
1.35 8.96e-07 GO:0022892 substrate-specific transporter activity
1.37 1.18e-06 GO:0022891 substrate-specific transmembrane transporter activity
1.40 3.24e-06 GO:0015075 ion transmembrane transporter activity
1.50 2.75e-05 GO:0022803 passive transmembrane transporter activity
2.33 2.87e-05 GO:0005496 steroid binding
1.50 4.21e-05 GO:0015267 channel activity
2.49 4.82e-05 GO:0003707 steroid hormone receptor activity
1.31 6.64e-05 GO:0030528 transcription regulator activity
2.42 6.88e-05 GO:0004879 ligand-dependent nuclear receptor activity
1.40 2.72e-04 GO:0008324 cation transmembrane transporter activity
1.47 3.17e-04 GO:0022838 substrate-specific channel activity
1.53 3.30e-04 GO:0022836 gated channel activity
1.34 3.55e-04 GO:0042802 identical protein binding
1.46 6.36e-04 GO:0005216 ion channel activity
1.42 6.63e-04 GO:0060589 nucleoside-triphosphatase regulator activity
1.42 8.59e-04 GO:0030695 GTPase regulator activity
1.43 9.01e-04 GO:0008289 lipid binding
1.35 1.02e-03 GO:0046983 protein dimerization activity
1.42 1.79e-03 GO:0042803 protein homodimerization activity
1.27 2.49e-03 GO:0030234 enzyme regulator activity
3.32 3.70e-03 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity
1.67 4.45e-03 GO:0005085 guanyl-nucleotide exchange factor activity
1.50 6.65e-03 GO:0005261 cation channel activity
1.48 8.02e-03 GO:0005083 small GTPase regulator activity
1.43 9.50e-03 GO:0022804 active transmembrane transporter activity
1.67 1.10e-02 GO:0008509 anion transmembrane transporter activity
2.73 1.91e-02 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
1.33 2.77e-02 GO:0008092 cytoskeletal protein binding
1.65 3.38e-02 GO:0005516 calmodulin binding
1.42 3.83e-02 GO:0016563 transcription activator activity
2.62 4.09e-02 GO:0004112 cyclic-nucleotide phosphodiesterase activity