Motif ID: TFAP2B.p2

Z-value: 1.884


Transcription factors associated with TFAP2B.p2:

Gene SymbolEntrez IDGene Name
TFAP2B 7021 transcription factor AP-2 beta (activating enhancer binding protein 2 beta)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TFAP2Bchr6_+_50786438-0.562.7e-19Click!


Activity profile for motif TFAP2B.p2.

activity profile for motif TFAP2B.p2


Sorted Z-values histogram for motif TFAP2B.p2

Sorted Z-values for motif TFAP2B.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TFAP2B.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr14_-_105261850 35.939 AKT1
v-akt murine thymoma viral oncogene homolog 1
chr12_-_123756164 29.580 NM_004642
CDK2AP1
cyclin-dependent kinase 2 associated protein 1
chr1_-_1822501 27.322 GNB1
guanine nucleotide binding protein (G protein), beta polypeptide 1
chr13_-_99229037 26.631 STK24
serine/threonine kinase 24
chrX_-_153602998 26.138 NM_001110556
NM_001456
FLNA

filamin A, alpha

chr4_-_1242882 24.689 NM_001012614
NM_001328
CTBP1

C-terminal binding protein 1

chr11_-_535532 24.559 NM_001130442
NM_005343
NM_176795
HRAS


v-Ha-ras Harvey rat sarcoma viral oncogene homolog


chr10_+_99185977 23.961 PGAM1
phosphoglycerate mutase 1 (brain)
chr11_-_64014407 23.687 NM_138689
PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr4_-_1242742 23.682 CTBP1
C-terminal binding protein 1
chr11_-_64014264 23.619 PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr8_+_146277789 23.156 NM_023080
C8orf33
chromosome 8 open reading frame 33
chr9_+_131451519 22.942 SET
SET nuclear oncogene
chr14_-_105262078 22.934 NM_001014431
NM_001014432
AKT1

v-akt murine thymoma viral oncogene homolog 1

chr8_+_146277830 22.817 C8orf33
chromosome 8 open reading frame 33
chr9_+_131451847 22.778 SET
SET nuclear oncogene
chr20_+_57466248 21.890 NM_000516
NM_001077488
NM_001077489
NM_080426
GNAS



GNAS complex locus



chr2_+_181845605 21.445 UBE2E3
ubiquitin-conjugating enzyme E2E 3
chr12_-_118498893 21.397 NM_018639
WSB2
WD repeat and SOCS box containing 2
chr2_+_102314162 21.386 NM_001242560
NM_004834
NM_145686
NM_001242559
NM_145687
MAP4K4




mitogen-activated protein kinase kinase kinase kinase 4




chr9_+_131451823 20.897 SET
SET nuclear oncogene
chr2_-_10588273 20.890 ODC1
ornithine decarboxylase 1
chr1_+_87794576 20.770 LMO4
LIM domain only 4
chr2_+_10262694 20.308 NM_001165931
RRM2
ribonucleotide reductase M2
chr1_-_1822493 20.213 GNB1
guanine nucleotide binding protein (G protein), beta polypeptide 1
chr1_-_150947202 19.840 CERS2
ceramide synthase 2
chr1_-_1822432 19.734 GNB1
CDK11B
guanine nucleotide binding protein (G protein), beta polypeptide 1
cyclin-dependent kinase 11B
chr10_+_99186012 19.709 PGAM1
phosphoglycerate mutase 1 (brain)
chr11_-_64014381 19.553 PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr14_-_105262015 19.493 AKT1
v-akt murine thymoma viral oncogene homolog 1
chr13_-_99229117 18.811 STK24
serine/threonine kinase 24
chr3_-_52567708 18.597 NM_001134231
NT5DC2
5'-nucleotidase domain containing 2
chrX_-_153285334 18.534 NM_001025242
NM_001025243
NM_001569
IRAK1


interleukin-1 receptor-associated kinase 1


chr2_+_10262853 18.369 NM_001034
RRM2
ribonucleotide reductase M2
chr15_-_101792125 18.276 NM_014918
CHSY1
chondroitin sulfate synthase 1
chr16_+_1359636 18.058 UBE2I
ubiquitin-conjugating enzyme E2I
chr18_-_9614454 17.660 PPP4R1
protein phosphatase 4, regulatory subunit 1
chr19_-_1567875 17.642 NM_001174118
NM_203304
MEX3D

mex-3 homolog D (C. elegans)

chr3_-_185542807 17.512 NM_001007225
NM_006548
IGF2BP2

insulin-like growth factor 2 mRNA binding protein 2

chr10_+_82213892 17.466 NM_001128309
NM_030927
TSPAN14

tetraspanin 14

chr16_+_1359673 17.342 UBE2I
ubiquitin-conjugating enzyme E2I
chr1_-_150947127 17.236 CERS2
ceramide synthase 2
chr2_+_216176818 17.230 ATIC
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
chr11_-_64014140 17.159 PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr13_+_33160651 16.797 PDS5B
PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)
chr16_+_89989686 16.710 NM_006086
TUBB3
tubulin, beta 3 class III
chrX_+_154611748 16.659 NM_001007523
NM_001007524
NM_012151
F8A2
F8A3
F8A1
coagulation factor VIII-associated 2
coagulation factor VIII-associated 3
coagulation factor VIII-associated 1
chr2_-_10588451 16.580 NM_002539
ODC1
ornithine decarboxylase 1
chr9_+_131452253 16.545 NM_001248001
SET
SET nuclear oncogene
chr1_-_94374986 16.516 NM_002061
GCLM
glutamate-cysteine ligase, modifier subunit
chr1_-_150947456 16.478 NM_022075
NM_181746
CERS2

ceramide synthase 2

chr20_+_62371109 16.260 NM_020062
SLC2A4RG
SLC2A4 regulator
chr1_-_150947292 16.189 CERS2
ceramide synthase 2
chr10_+_99186040 16.174 PGAM1
phosphoglycerate mutase 1 (brain)
chr1_-_156721501 16.106 NM_004494
HDGF
hepatoma-derived growth factor
chr20_+_62371730 16.102 SLC2A4RG
SLC2A4 regulator
chr5_+_6714717 16.080 NM_001171805
NM_006999
PAPD7

PAP associated domain containing 7

chr17_-_62658311 16.053 NM_022739
SMURF2
SMAD specific E3 ubiquitin protein ligase 2
chr20_+_62371218 15.882 SLC2A4RG
SLC2A4 regulator
chrX_-_15872905 15.856


chr10_+_99186042 15.845 PGAM1
phosphoglycerate mutase 1 (brain)
chr11_-_14380591 15.694 NM_012250
RRAS2
related RAS viral (r-ras) oncogene homolog 2
chr16_-_87903028 15.645 NM_003486
SLC7A5
solute carrier family 7 (amino acid transporter light chain, L system), member 5
chr20_+_62371619 15.496 SLC2A4RG
SLC2A4 regulator
chrX_-_153285262 15.381 IRAK1
interleukin-1 receptor-associated kinase 1
chr20_+_388941 15.224 RBCK1
RanBP-type and C3HC4-type zinc finger containing 1
chr1_-_94374949 15.216 GCLM
glutamate-cysteine ligase, modifier subunit
chr20_-_60718358 15.097 PSMA7
proteasome (prosome, macropain) subunit, alpha type, 7
chr20_+_57466509 14.908 GNAS
GNAS complex locus
chr1_-_150947154 14.903 CERS2
ceramide synthase 2
chr3_-_195808934 14.801 TFRC
transferrin receptor (p90, CD71)
chr13_-_99229226 14.760 NM_001032296
STK24
serine/threonine kinase 24
chr1_+_230202928 14.666 NM_004481
GALNT2
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2)
chr12_-_109125289 14.551 NM_014325
CORO1C
coronin, actin binding protein, 1C
chr2_-_225449721 14.499 CUL3
cullin 3
chr16_+_1359653 14.425 UBE2I
ubiquitin-conjugating enzyme E2I
chr12_-_109125275 14.409 CORO1C
coronin, actin binding protein, 1C
chr1_-_150947305 14.393 CERS2
ceramide synthase 2
chr16_-_85832900 14.380 NM_001142288
NM_006067
COX4NB

COX4 neighbor

chr2_+_216176678 14.346 NM_004044
ATIC
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
chrX_+_150151757 14.281 NM_005342
HMGB3
high mobility group box 3
chr1_-_1284297 14.268 NM_004421
DVL1
dishevelled, dsh homolog 1 (Drosophila)
chr14_+_56046796 14.212 NM_001079521
NM_001079522
NM_004986
NM_182926
KTN1



kinectin 1 (kinesin receptor)



chr18_-_9614555 14.022 NM_001042388
NM_005134
PPP4R1

protein phosphatase 4, regulatory subunit 1

chr3_-_52567809 14.001 NT5DC2
5'-nucleotidase domain containing 2
chr3_-_33481862 13.978 NM_001128160
NM_014517
UBP1

upstream binding protein 1 (LBP-1a)

chr16_+_1359692 13.949 UBE2I
ubiquitin-conjugating enzyme E2I
chrX_+_154114609 13.655 NM_001007523
NM_001007524
NM_012151
F8A2
F8A3
F8A1
coagulation factor VIII-associated 2
coagulation factor VIII-associated 3
coagulation factor VIII-associated 1
chr22_+_21922020 13.640 UBE2L3
ubiquitin-conjugating enzyme E2L 3
chr2_-_161349874 13.598 RBMS1
RNA binding motif, single stranded interacting protein 1
chr19_-_41859519 13.570 TGFB1
transforming growth factor, beta 1
chr18_-_51750934 13.558 MBD2
methyl-CpG binding domain protein 2
chr20_-_60718407 13.501 PSMA7
proteasome (prosome, macropain) subunit, alpha type, 7
chr12_-_106641675 13.494 NM_006825
CKAP4
cytoskeleton-associated protein 4
chr2_-_174829108 13.468 SP3
Sp3 transcription factor
chr9_+_131451470 13.461 NM_003011
SET
SET nuclear oncogene
chr2_+_216176808 13.368 ATIC
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
chr20_-_60718440 13.326 NM_002792
PSMA7
proteasome (prosome, macropain) subunit, alpha type, 7
chr3_-_182698291 13.260 NM_020640
DCUN1D1
DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)
chr3_-_185542744 13.247 IGF2BP2
insulin-like growth factor 2 mRNA binding protein 2
chr3_-_195808958 13.223 NM_003234
TFRC
transferrin receptor (p90, CD71)
chr3_-_129035069 13.220 NM_006026
H1FX
H1 histone family, member X
chr3_-_149688638 13.140 NM_002628
NM_053024
PFN2

profilin 2

chr10_+_99186017 13.040 NM_002629
PGAM1
phosphoglycerate mutase 1 (brain)
chr10_+_99186004 13.024 PGAM1
phosphoglycerate mutase 1 (brain)
chr5_+_138089073 13.015 NM_001903
CTNNA1
catenin (cadherin-associated protein), alpha 1, 102kDa
chr5_+_138089118 12.953 CTNNA1
catenin (cadherin-associated protein), alpha 1, 102kDa
chrX_-_15872882 12.947 AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr15_+_63796793 12.890 NM_006537
USP3
ubiquitin specific peptidase 3
chr22_+_21922026 12.780 UBE2L3
ubiquitin-conjugating enzyme E2L 3
chr1_-_224622000 12.779 NM_001115113
NM_025160
WDR26

WD repeat domain 26

chr19_-_41859830 12.763 NM_000660
TGFB1
transforming growth factor, beta 1
chr11_-_14380030 12.578 NM_001177315
NM_001102669
RRAS2

related RAS viral (r-ras) oncogene homolog 2

chr5_-_1524022 12.490 NM_024830
LPCAT1
lysophosphatidylcholine acyltransferase 1
chr20_+_388717 12.464 RBCK1
RanBP-type and C3HC4-type zinc finger containing 1
chr17_-_56065596 12.440 NM_007146
VEZF1
vascular endothelial zinc finger 1
chr9_+_114659023 12.414 NM_003358
UGCG
UDP-glucose ceramide glucosyltransferase
chr6_-_7910716 12.395 NM_030810
TXNDC5
thioredoxin domain containing 5 (endoplasmic reticulum)
chr22_+_21922004 12.240 UBE2L3
ubiquitin-conjugating enzyme E2L 3
chr1_-_156721280 12.230 HDGF
hepatoma-derived growth factor
chrX_-_154688260 12.207 NM_001007523
NM_001007524
NM_012151
F8A2
F8A3
F8A1
coagulation factor VIII-associated 2
coagulation factor VIII-associated 3
coagulation factor VIII-associated 1
chr17_-_76921076 12.082 TIMP2
TIMP metallopeptidase inhibitor 2
chr19_-_41859332 11.947 TGFB1
transforming growth factor, beta 1
chr12_-_109125254 11.911 CORO1C
coronin, actin binding protein, 1C
chr3_-_63849456 11.791 THOC7
THO complex 7 homolog (Drosophila)
chr3_+_141595368 11.737 NM_001679
ATP1B3
ATPase, Na+/K+ transporting, beta 3 polypeptide
chr9_+_133710746 11.708 NM_005157
ABL1
c-abl oncogene 1, non-receptor tyrosine kinase
chr11_-_64545864 11.686 SF1
splicing factor 1
chr6_-_13814546 11.682 NM_001031713
CCDC90A
coiled-coil domain containing 90A
chr9_+_114659439 11.618 UGCG
UDP-glucose ceramide glucosyltransferase
chr12_-_111180730 11.533 NM_001244974
NM_002710
PPP1CC

protein phosphatase 1, catalytic subunit, gamma isozyme

chr7_+_56119377 11.525 NM_001009186
NM_001762
CCT6A

chaperonin containing TCP1, subunit 6A (zeta 1)

chr15_+_80351909 11.499 NM_001242911
NM_001242912
NM_001242917
NM_001242918
NM_019006
ZFAND6




zinc finger, AN1-type domain 6




chr11_+_67033929 11.491 ADRBK1
adrenergic, beta, receptor kinase 1
chr13_+_33160630 11.410 PDS5B
PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)
chr6_-_53213586 11.383 ELOVL5
ELOVL fatty acid elongase 5
chr12_-_47473424 11.358 NM_001143668
NM_181847
AMIGO2

adhesion molecule with Ig-like domain 2

chr11_+_67033889 11.356 NM_001619
ADRBK1
adrenergic, beta, receptor kinase 1
chr9_+_110045551 11.241 RAD23B
RAD23 homolog B (S. cerevisiae)
chr1_-_94375028 11.191 GCLM
glutamate-cysteine ligase, modifier subunit
chr16_-_9057250 11.180 NM_003470
USP7
ubiquitin specific peptidase 7 (herpes virus-associated)
chr9_+_110045516 11.115 NM_002874
RAD23B
RAD23 homolog B (S. cerevisiae)
chr6_+_163835668 11.018 NM_006775
NM_206853
NM_206854
NM_206855
QKI



QKI, KH domain containing, RNA binding



chr4_+_174089889 10.986 NM_017423
GALNT7
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7 (GalNAc-T7)
chr6_-_52441815 10.952 NM_012288
TRAM2
translocation associated membrane protein 2
chr7_-_121036355 10.931 NM_001040020
NM_014888
FAM3C

family with sequence similarity 3, member C

chr17_-_62658175 10.795 SMURF2
SMAD specific E3 ubiquitin protein ligase 2
chr17_-_4851797 10.778 NM_005022
PFN1
profilin 1
chrX_-_15872938 10.772 AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr2_+_85198176 10.737 NM_020122
KCMF1
potassium channel modulatory factor 1
chr9_+_96338671 10.700 NM_005392
PHF2
PHD finger protein 2
chr16_-_88851371 10.667 NM_001142864
PIEZO1
piezo-type mechanosensitive ion channel component 1
chrX_-_15872921 10.633 AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr5_+_892950 10.600 NM_001166260
NM_004237
TRIP13

thyroid hormone receptor interactor 13

chr17_+_30771520 10.581 PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr9_+_128509616 10.569 NM_006195
PBX3
pre-B-cell leukemia homeobox 3
chr14_+_100705101 10.563 NM_003403
YY1
YY1 transcription factor
chr17_-_4269610 10.499 UBE2G1
ubiquitin-conjugating enzyme E2G 1
chr3_+_141595512 10.489 ATP1B3
ATPase, Na+/K+ transporting, beta 3 polypeptide
chr17_-_4851688 10.386 PFN1
profilin 1
chr12_+_2904289 10.323 FKBP4
FK506 binding protein 4, 59kDa
chr5_-_57755787 10.250 NM_001252226
NM_006622
PLK2

polo-like kinase 2

chr20_+_57556322 10.163 TH1L
TH1-like (Drosophila)
chr1_-_11120001 10.133 SRM
spermidine synthase
chr15_+_63334753 10.111 NM_000366
NM_001018004
NM_001018005
NM_001018006
NM_001018007
NM_001018020
TPM1





tropomyosin 1 (alpha)





chr3_-_195808997 10.062 NM_001128148
TFRC
transferrin receptor (p90, CD71)
chr1_-_1284755 10.029 DVL1
dishevelled, dsh homolog 1 (Drosophila)
chr16_+_730114 10.016 NM_005861
STUB1
STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
chr9_-_139378192 9.981 SEC16A
SEC16 homolog A (S. cerevisiae)
chrX_+_118602362 9.941 NM_001152
SLC25A5
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
chrX_+_133594225 9.895 HPRT1
hypoxanthine phosphoribosyltransferase 1
chr16_+_2564000 9.891 ATP6V0C
ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
chr1_-_95392501 9.887 NM_001839
CNN3
calponin 3, acidic
chr1_+_29063443 9.880 NM_001172828
YTHDF2
YTH domain family, member 2
chrX_+_118602391 9.842 SLC25A5
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
chr1_-_1822516 9.791 NM_002074
GNB1
guanine nucleotide binding protein (G protein), beta polypeptide 1
chr5_-_112257877 9.781 NM_005669
REEP5
receptor accessory protein 5
chr14_+_105941061 9.769 NM_001312
CRIP2
cysteine-rich protein 2
chr14_-_89883306 9.763 NM_005197
FOXN3
forkhead box N3
chr9_+_110046333 9.757 NM_001244724
RAD23B
RAD23 homolog B (S. cerevisiae)
chr1_+_214454276 9.747 NM_020197
SMYD2
SET and MYND domain containing 2
chr20_+_31407696 9.679 NM_012325
MAPRE1
microtubule-associated protein, RP/EB family, member 1
chr17_-_56065474 9.643 VEZF1
vascular endothelial zinc finger 1
chr19_+_1941157 9.561 NM_001319
CSNK1G2
casein kinase 1, gamma 2
chr1_+_955468 9.513 NM_198576
AGRN
agrin
chr4_+_1723212 9.478 NM_006342
TACC3
transforming, acidic coiled-coil containing protein 3
chr7_-_121036320 9.465 FAM3C
family with sequence similarity 3, member C
chr2_+_231921595 9.369 PSMD1
proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
chr16_+_29817810 9.278 NM_001042539
NM_002383
MAZ

MYC-associated zinc finger protein (purine-binding transcription factor)

chr6_-_160114318 9.257 NM_000636
NM_001024465
NM_001024466
SOD2


superoxide dismutase 2, mitochondrial


chr16_-_47177902 9.170 NM_001201477
NM_018092
NETO2

neuropilin (NRP) and tolloid (TLL)-like 2

chr2_-_61764661 9.163 XPO1
exportin 1 (CRM1 homolog, yeast)
chr16_-_47177832 9.151 NETO2
neuropilin (NRP) and tolloid (TLL)-like 2
chr16_+_67562704 9.136 NM_024519
NM_001193522
FAM65A

family with sequence similarity 65, member A

chr14_+_100705279 9.087 YY1
YY1 transcription factor
chr4_+_62066945 9.021 LPHN3
latrophilin 3
chr4_-_1713914 8.918 NM_006527
SLBP
stem-loop binding protein
chr8_+_98656494 8.909 MTDH
metadherin
chr8_-_30669934 8.896 PPP2CB
protein phosphatase 2, catalytic subunit, beta isozyme
chr15_+_80352257 8.892 NM_001242913
ZFAND6
zinc finger, AN1-type domain 6

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.17 4.21e-58 GO:0009987 cellular process
1.30 1.09e-50 GO:0044237 cellular metabolic process
1.25 2.31e-44 GO:0008152 metabolic process
1.26 1.49e-39 GO:0044238 primary metabolic process
1.31 8.68e-33 GO:0044260 cellular macromolecule metabolic process
1.27 4.69e-29 GO:0043170 macromolecule metabolic process
1.19 1.16e-26 GO:0050789 regulation of biological process
1.20 2.14e-26 GO:0050794 regulation of cellular process
1.18 4.53e-26 GO:0065007 biological regulation
1.32 3.66e-24 GO:0016043 cellular component organization
1.30 3.80e-22 GO:0071840 cellular component organization or biogenesis
1.37 7.10e-19 GO:0048523 negative regulation of cellular process
1.34 1.13e-18 GO:0044267 cellular protein metabolic process
1.29 1.47e-18 GO:0006807 nitrogen compound metabolic process
1.35 1.80e-18 GO:0048519 negative regulation of biological process
1.29 2.16e-18 GO:0034641 cellular nitrogen compound metabolic process
1.25 5.64e-18 GO:0019222 regulation of metabolic process
1.32 2.66e-17 GO:0071842 cellular component organization at cellular level
1.26 3.93e-17 GO:0031323 regulation of cellular metabolic process
1.39 6.20e-17 GO:0006464 protein modification process
1.33 1.39e-16 GO:0044249 cellular biosynthetic process
1.30 7.22e-16 GO:0071841 cellular component organization or biogenesis at cellular level
1.28 7.87e-16 GO:0019538 protein metabolic process
1.37 8.11e-16 GO:0043412 macromolecule modification
1.25 9.33e-16 GO:0080090 regulation of primary metabolic process
1.32 1.14e-15 GO:0048522 positive regulation of cellular process
1.30 1.55e-15 GO:0048518 positive regulation of biological process
1.31 2.50e-15 GO:0009058 biosynthetic process
1.29 1.64e-14 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.25 3.63e-14 GO:0060255 regulation of macromolecule metabolic process
1.23 1.19e-13 GO:0032502 developmental process
1.37 9.61e-13 GO:0023051 regulation of signaling
1.43 3.92e-12 GO:0010604 positive regulation of macromolecule metabolic process
1.24 2.30e-11 GO:0048856 anatomical structure development
1.22 2.33e-11 GO:0007275 multicellular organismal development
1.40 2.99e-11 GO:0009893 positive regulation of metabolic process
1.20 4.04e-11 GO:0051716 cellular response to stimulus
1.37 6.03e-11 GO:0009966 regulation of signal transduction
1.34 6.07e-11 GO:0006996 organelle organization
1.20 3.08e-10 GO:0023052 signaling
1.38 4.60e-10 GO:0051641 cellular localization
1.24 7.45e-10 GO:0048731 system development
1.24 1.31e-09 GO:0031326 regulation of cellular biosynthetic process
1.24 1.54e-09 GO:0009889 regulation of biosynthetic process
1.40 1.61e-09 GO:0051246 regulation of protein metabolic process
1.26 1.87e-09 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.38 2.13e-09 GO:0031325 positive regulation of cellular metabolic process
1.21 2.87e-09 GO:0007165 signal transduction
1.41 3.95e-09 GO:0032268 regulation of cellular protein metabolic process
1.24 5.03e-09 GO:0010468 regulation of gene expression
1.27 5.24e-09 GO:0048869 cellular developmental process
1.26 6.13e-09 GO:0042221 response to chemical stimulus
1.30 6.17e-09 GO:0044281 small molecule metabolic process
1.26 7.42e-09 GO:0090304 nucleic acid metabolic process
1.25 8.40e-09 GO:0010556 regulation of macromolecule biosynthetic process
1.33 1.01e-08 GO:0007399 nervous system development
1.31 1.10e-08 GO:0034645 cellular macromolecule biosynthetic process
1.43 1.36e-08 GO:0006351 transcription, DNA-dependent
1.41 1.36e-08 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.50 2.38e-08 GO:0007167 enzyme linked receptor protein signaling pathway
1.30 2.67e-08 GO:0009059 macromolecule biosynthetic process
1.34 2.72e-08 GO:0033036 macromolecule localization
1.45 2.95e-08 GO:0046907 intracellular transport
1.26 6.63e-08 GO:0030154 cell differentiation
1.43 7.96e-08 GO:0051128 regulation of cellular component organization
1.36 1.47e-07 GO:0051649 establishment of localization in cell
1.22 1.60e-07 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.25 1.81e-07 GO:0065008 regulation of biological quality
1.40 2.25e-07 GO:0050793 regulation of developmental process
1.50 3.05e-07 GO:0000902 cell morphogenesis
1.21 3.06e-07 GO:0051171 regulation of nitrogen compound metabolic process
1.53 4.33e-07 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.37 7.05e-07 GO:0032774 RNA biosynthetic process
1.37 7.07e-07 GO:0006793 phosphorus metabolic process
1.37 7.07e-07 GO:0006796 phosphate metabolic process
1.37 8.86e-07 GO:0032879 regulation of localization
1.27 1.04e-06 GO:0016070 RNA metabolic process
1.29 1.32e-06 GO:0065009 regulation of molecular function
1.29 1.38e-06 GO:0009653 anatomical structure morphogenesis
1.38 1.73e-06 GO:0048468 cell development
1.39 2.19e-06 GO:0033554 cellular response to stress
1.17 2.49e-06 GO:0051179 localization
1.34 3.07e-06 GO:0010646 regulation of cell communication
1.45 3.08e-06 GO:0032989 cellular component morphogenesis
1.36 3.28e-06 GO:0009892 negative regulation of metabolic process
1.41 3.88e-06 GO:0016192 vesicle-mediated transport
1.34 4.60e-06 GO:0008104 protein localization
1.41 5.06e-06 GO:0006468 protein phosphorylation
1.22 5.12e-06 GO:0051252 regulation of RNA metabolic process
1.56 6.24e-06 GO:0051247 positive regulation of protein metabolic process
1.43 7.62e-06 GO:0045595 regulation of cell differentiation
1.50 8.13e-06 GO:0000904 cell morphogenesis involved in differentiation
1.61 8.81e-06 GO:0071495 cellular response to endogenous stimulus
1.24 1.11e-05 GO:0010467 gene expression
1.30 1.27e-05 GO:0010033 response to organic substance
1.49 1.43e-05 GO:0048858 cell projection morphogenesis
1.49 1.65e-05 GO:0032990 cell part morphogenesis
1.24 1.75e-05 GO:0048583 regulation of response to stimulus
1.33 1.75e-05 GO:0043067 regulation of programmed cell death
1.35 1.80e-05 GO:0010605 negative regulation of macromolecule metabolic process
1.36 2.13e-05 GO:0031324 negative regulation of cellular metabolic process
1.22 2.59e-05 GO:0006355 regulation of transcription, DNA-dependent
1.35 2.85e-05 GO:0022008 neurogenesis
1.34 3.01e-05 GO:0042127 regulation of cell proliferation
1.36 3.08e-05 GO:0008219 cell death
1.32 3.11e-05 GO:0010941 regulation of cell death
1.36 3.18e-05 GO:0048699 generation of neurons
1.36 3.34e-05 GO:0016265 death
1.42 3.51e-05 GO:0030030 cell projection organization
1.18 3.58e-05 GO:0051234 establishment of localization
1.54 3.61e-05 GO:0032270 positive regulation of cellular protein metabolic process
1.32 3.63e-05 GO:0042981 regulation of apoptosis
1.35 4.04e-05 GO:0045184 establishment of protein localization
1.36 4.44e-05 GO:0016310 phosphorylation
1.29 5.19e-05 GO:0051239 regulation of multicellular organismal process
1.18 6.55e-05 GO:0006810 transport
1.59 9.06e-05 GO:0032870 cellular response to hormone stimulus
1.32 1.06e-04 GO:0007049 cell cycle
1.39 1.14e-04 GO:0009719 response to endogenous stimulus
1.41 1.17e-04 GO:0051726 regulation of cell cycle
1.36 1.20e-04 GO:0031399 regulation of protein modification process
1.49 1.22e-04 GO:0048812 neuron projection morphogenesis
1.39 1.29e-04 GO:0009890 negative regulation of biosynthetic process
1.54 1.35e-04 GO:0016568 chromatin modification
1.27 1.36e-04 GO:0035556 intracellular signal transduction
1.39 1.38e-04 GO:0031327 negative regulation of cellular biosynthetic process
1.61 1.41e-04 GO:0032446 protein modification by small protein conjugation
1.56 1.44e-04 GO:0070647 protein modification by small protein conjugation or removal
1.95 1.50e-04 GO:0007265 Ras protein signal transduction
1.39 1.54e-04 GO:0010628 positive regulation of gene expression
1.10 1.73e-04 GO:0050896 response to stimulus
1.48 2.01e-04 GO:0048667 cell morphogenesis involved in neuron differentiation
1.68 2.27e-04 GO:0048011 nerve growth factor receptor signaling pathway
1.29 2.30e-04 GO:0044248 cellular catabolic process
1.34 2.36e-04 GO:0015031 protein transport
1.34 2.75e-04 GO:0031328 positive regulation of cellular biosynthetic process
1.38 2.81e-04 GO:0051254 positive regulation of RNA metabolic process
1.36 2.99e-04 GO:2000026 regulation of multicellular organismal development
1.49 3.02e-04 GO:0007409 axonogenesis
1.55 3.12e-04 GO:0051098 regulation of binding
1.25 3.69e-04 GO:0009056 catabolic process
1.33 3.87e-04 GO:0009891 positive regulation of biosynthetic process
1.52 4.01e-04 GO:0044419 interspecies interaction between organisms
1.37 4.77e-04 GO:0019220 regulation of phosphate metabolic process
1.37 4.77e-04 GO:0051174 regulation of phosphorus metabolic process
1.38 4.92e-04 GO:0010558 negative regulation of macromolecule biosynthetic process
1.39 5.65e-04 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.44 6.27e-04 GO:0031175 neuron projection development
1.44 7.13e-04 GO:0006325 chromatin organization
1.58 7.62e-04 GO:0010608 posttranscriptional regulation of gene expression
1.35 8.35e-04 GO:0010557 positive regulation of macromolecule biosynthetic process
1.34 1.05e-03 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
2.16 1.22e-03 GO:0006921 cellular component disassembly involved in apoptosis
1.38 1.32e-03 GO:0009725 response to hormone stimulus
1.59 1.41e-03 GO:0016567 protein ubiquitination
1.73 1.48e-03 GO:0006417 regulation of translation
1.51 1.66e-03 GO:0007411 axon guidance
1.37 1.67e-03 GO:0051276 chromosome organization
1.36 1.69e-03 GO:0042325 regulation of phosphorylation
1.33 1.70e-03 GO:0051173 positive regulation of nitrogen compound metabolic process
1.38 1.80e-03 GO:0010629 negative regulation of gene expression
1.42 1.84e-03 GO:0070271 protein complex biogenesis
1.40 1.92e-03 GO:0051253 negative regulation of RNA metabolic process
1.34 1.96e-03 GO:0012501 programmed cell death
1.34 2.04e-03 GO:0006915 apoptosis
1.26 2.31e-03 GO:0050790 regulation of catalytic activity
1.46 2.66e-03 GO:0007264 small GTPase mediated signal transduction
1.32 2.74e-03 GO:0044093 positive regulation of molecular function
1.36 2.84e-03 GO:0001932 regulation of protein phosphorylation
1.62 3.02e-03 GO:0045786 negative regulation of cell cycle
1.32 3.24e-03 GO:0022402 cell cycle process
1.41 3.27e-03 GO:0006461 protein complex assembly
1.33 3.40e-03 GO:0051049 regulation of transport
1.36 3.44e-03 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
2.24 4.04e-03 GO:0007163 establishment or maintenance of cell polarity
1.76 4.26e-03 GO:0051099 positive regulation of binding
1.43 4.62e-03 GO:0010648 negative regulation of cell communication
1.36 4.65e-03 GO:0045893 positive regulation of transcription, DNA-dependent
2.19 5.16e-03 GO:0001889 liver development
1.38 5.26e-03 GO:0045892 negative regulation of transcription, DNA-dependent
1.35 5.62e-03 GO:0051172 negative regulation of nitrogen compound metabolic process
1.39 5.62e-03 GO:0070727 cellular macromolecule localization
1.52 6.34e-03 GO:0051270 regulation of cellular component movement
1.41 6.74e-03 GO:0060548 negative regulation of cell death
1.39 7.33e-03 GO:0044283 small molecule biosynthetic process
1.19 7.65e-03 GO:0048513 organ development
1.47 8.25e-03 GO:0018193 peptidyl-amino acid modification
1.40 8.27e-03 GO:0072358 cardiovascular system development
1.40 8.27e-03 GO:0072359 circulatory system development
2.15 8.55e-03 GO:0061008 hepaticobiliary system development
1.48 8.63e-03 GO:0032535 regulation of cellular component size
1.36 8.71e-03 GO:0048666 neuron development
1.54 8.81e-03 GO:0030334 regulation of cell migration
1.62 9.05e-03 GO:0044087 regulation of cellular component biogenesis
1.57 9.17e-03 GO:0051129 negative regulation of cellular component organization
1.16 9.65e-03 GO:0006950 response to stress
1.38 9.69e-03 GO:0034613 cellular protein localization
1.41 1.13e-02 GO:0023057 negative regulation of signaling
1.57 1.21e-02 GO:0071375 cellular response to peptide hormone stimulus
1.44 1.25e-02 GO:0044271 cellular nitrogen compound biosynthetic process
2.75 1.42e-02 GO:0030010 establishment of cell polarity
1.44 1.55e-02 GO:0090066 regulation of anatomical structure size
1.52 1.63e-02 GO:2000145 regulation of cell motility
1.64 1.67e-02 GO:0006913 nucleocytoplasmic transport
1.76 1.68e-02 GO:0006403 RNA localization
1.32 1.70e-02 GO:0065003 macromolecular complex assembly
1.33 1.87e-02 GO:0071310 cellular response to organic substance
1.32 1.90e-02 GO:0030182 neuron differentiation
1.29 1.90e-02 GO:0043933 macromolecular complex subunit organization
1.49 2.02e-02 GO:0006366 transcription from RNA polymerase II promoter
1.32 2.06e-02 GO:0046483 heterocycle metabolic process
1.63 2.13e-02 GO:0016569 covalent chromatin modification
1.41 2.21e-02 GO:0009968 negative regulation of signal transduction
1.72 2.32e-02 GO:0006112 energy reserve metabolic process
1.25 2.35e-02 GO:0022607 cellular component assembly
1.47 2.56e-02 GO:0031401 positive regulation of protein modification process
1.61 2.60e-02 GO:0010562 positive regulation of phosphorus metabolic process
1.61 2.60e-02 GO:0045937 positive regulation of phosphate metabolic process
1.39 2.67e-02 GO:0008283 cell proliferation
1.62 2.71e-02 GO:0051169 nuclear transport
1.75 2.95e-02 GO:0050657 nucleic acid transport
1.75 2.95e-02 GO:0050658 RNA transport
1.75 2.95e-02 GO:0051236 establishment of RNA localization
1.46 3.03e-02 GO:0051093 negative regulation of developmental process
1.33 3.30e-02 GO:0009057 macromolecule catabolic process
1.47 3.67e-02 GO:0009199 ribonucleoside triphosphate metabolic process
1.96 3.70e-02 GO:0007173 epidermal growth factor receptor signaling pathway
1.33 3.78e-02 GO:0071822 protein complex subunit organization
1.61 4.56e-02 GO:0016570 histone modification
1.34 4.81e-02 GO:0055086 nucleobase, nucleoside and nucleotide metabolic process
1.77 4.99e-02 GO:0051028 mRNA transport

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.17 4.29e-65 GO:0044424 intracellular part
1.16 1.43e-64 GO:0005622 intracellular
1.23 3.84e-54 GO:0005737 cytoplasm
1.18 6.42e-45 GO:0043226 organelle
1.18 1.13e-44 GO:0043229 intracellular organelle
1.19 1.36e-41 GO:0043227 membrane-bounded organelle
1.19 5.34e-41 GO:0043231 intracellular membrane-bounded organelle
1.24 2.58e-34 GO:0044444 cytoplasmic part
1.23 4.83e-26 GO:0044422 organelle part
1.23 1.12e-25 GO:0044446 intracellular organelle part
1.41 9.95e-24 GO:0005829 cytosol
1.21 2.07e-21 GO:0005634 nucleus
1.36 1.24e-19 GO:0044428 nuclear part
1.33 1.58e-17 GO:0031974 membrane-enclosed lumen
1.33 1.02e-16 GO:0043233 organelle lumen
1.33 2.56e-16 GO:0070013 intracellular organelle lumen
1.36 5.54e-16 GO:0031981 nuclear lumen
1.41 2.46e-14 GO:0005654 nucleoplasm
1.05 4.80e-14 GO:0044464 cell part
1.05 5.32e-14 GO:0005623 cell
1.21 2.45e-09 GO:0043234 protein complex
1.19 6.26e-09 GO:0032991 macromolecular complex
1.29 1.36e-08 GO:0012505 endomembrane system
1.31 2.29e-06 GO:0000267 cell fraction
1.33 3.04e-06 GO:0005794 Golgi apparatus
1.18 5.54e-06 GO:0043228 non-membrane-bounded organelle
1.18 5.54e-06 GO:0043232 intracellular non-membrane-bounded organelle
1.37 1.72e-05 GO:0044451 nucleoplasm part
1.20 7.37e-05 GO:0031090 organelle membrane
1.61 1.38e-04 GO:0005635 nuclear envelope
1.69 2.27e-04 GO:0031252 cell leading edge
1.39 2.37e-04 GO:0005694 chromosome
1.49 4.68e-04 GO:0005625 soluble fraction
1.30 7.05e-04 GO:0005626 insoluble fraction
1.32 8.12e-04 GO:0031975 envelope
2.11 1.14e-03 GO:0031256 leading edge membrane
1.71 1.16e-03 GO:0005912 adherens junction
2.47 1.55e-03 GO:0032587 ruffle membrane
1.31 2.32e-03 GO:0031967 organelle envelope
1.28 3.13e-03 GO:0005624 membrane fraction
1.33 3.54e-03 GO:0044431 Golgi apparatus part
1.43 3.95e-03 GO:0048471 perinuclear region of cytoplasm
1.52 5.54e-03 GO:0000785 chromatin
1.61 6.88e-03 GO:0070161 anchoring junction
1.26 9.33e-03 GO:0042995 cell projection
1.44 1.19e-02 GO:0015629 actin cytoskeleton
1.26 1.37e-02 GO:0031982 vesicle
1.49 1.59e-02 GO:0016323 basolateral plasma membrane
1.18 2.47e-02 GO:0005856 cytoskeleton
1.26 3.61e-02 GO:0031988 membrane-bounded vesicle
1.33 3.88e-02 GO:0044427 chromosomal part
1.99 3.99e-02 GO:0016605 PML body
1.26 4.05e-02 GO:0016023 cytoplasmic membrane-bounded vesicle
1.25 4.22e-02 GO:0031410 cytoplasmic vesicle
3.97 4.53e-02 GO:0005606 laminin-1 complex
3.97 4.53e-02 GO:0005885 Arp2/3 protein complex
1.47 4.99e-02 GO:0016604 nuclear body

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.29 1.10e-65 GO:0005515 protein binding
1.14 1.50e-47 GO:0005488 binding
1.27 4.44e-11 GO:0000166 nucleotide binding
1.15 1.34e-10 GO:0003824 catalytic activity
1.48 7.10e-10 GO:0019899 enzyme binding
1.41 9.48e-09 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.59 1.64e-08 GO:0019904 protein domain specific binding
1.42 7.75e-08 GO:0016301 kinase activity
1.43 9.01e-08 GO:0042802 identical protein binding
1.25 3.70e-07 GO:0017076 purine nucleotide binding
1.24 8.02e-07 GO:0032553 ribonucleotide binding
1.24 8.02e-07 GO:0032555 purine ribonucleotide binding
1.26 8.33e-07 GO:0016740 transferase activity
1.41 9.29e-07 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.24 1.56e-06 GO:0035639 purine ribonucleoside triphosphate binding
1.56 2.39e-06 GO:0003712 transcription cofactor activity
1.56 2.97e-06 GO:0000988 protein binding transcription factor activity
1.56 2.97e-06 GO:0000989 transcription factor binding transcription factor activity
1.42 3.29e-06 GO:0046983 protein dimerization activity
1.26 3.65e-06 GO:0030554 adenyl nucleotide binding
1.25 9.79e-06 GO:0032559 adenyl ribonucleotide binding
1.86 1.66e-05 GO:0003714 transcription corepressor activity
1.60 2.02e-05 GO:0008134 transcription factor binding
1.41 2.17e-05 GO:0004672 protein kinase activity
1.32 2.23e-05 GO:0001071 nucleic acid binding transcription factor activity
1.32 2.23e-05 GO:0003700 sequence-specific DNA binding transcription factor activity
1.25 2.65e-05 GO:0005524 ATP binding
1.45 1.95e-04 GO:0004674 protein serine/threonine kinase activity
1.66 4.20e-04 GO:0010843 promoter binding
1.63 6.78e-04 GO:0000975 regulatory region DNA binding
1.63 6.78e-04 GO:0001067 regulatory region nucleic acid binding
1.63 6.78e-04 GO:0044212 transcription regulatory region DNA binding
2.38 1.06e-03 GO:0046332 SMAD binding
1.33 1.74e-03 GO:0043565 sequence-specific DNA binding
1.16 3.10e-03 GO:0003677 DNA binding
1.13 4.91e-03 GO:0003676 nucleic acid binding
1.91 1.24e-02 GO:0031625 ubiquitin protein ligase binding
1.33 1.38e-02 GO:0008092 cytoskeletal protein binding
1.48 1.55e-02 GO:0032403 protein complex binding
3.36 1.61e-02 GO:0070412 R-SMAD binding
1.43 1.89e-02 GO:0016563 transcription activator activity
1.50 2.60e-02 GO:0046982 protein heterodimerization activity
1.90 3.02e-02 GO:0047485 protein N-terminus binding
1.47 3.83e-02 GO:0016791 phosphatase activity