Motif ID: TLX2.p2

Z-value: 1.383


Transcription factors associated with TLX2.p2:

Gene SymbolEntrez IDGene Name
TLX2 3196 T-cell leukemia homeobox 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TLX2chr2_+_747415650.464.7e-13Click!


Activity profile for motif TLX2.p2.

activity profile for motif TLX2.p2


Sorted Z-values histogram for motif TLX2.p2

Sorted Z-values for motif TLX2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TLX2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_+_111303240 22.063 NM_032194
RPF2
ribosome production factor 2 homolog (S. cerevisiae)
chr12_-_91572328 18.513 NM_133504
NM_133505
NM_133506
NM_133507
DCN



decorin



chr1_-_153363544 17.530 NM_002964
S100A8
S100 calcium binding protein A8
chr19_-_37019169 17.038 NM_001012756
NM_001166036
NM_001166037
NM_001166038
ZNF260



zinc finger protein 260



chr20_+_47895168 16.058 ZNFX1-AS1
ZNFX1 antisense RNA 1 (non-protein coding)
chr16_+_84853585 15.223 NM_031476
CRISPLD2
cysteine-rich secretory protein LCCL domain containing 2
chr15_+_74422920 14.654 ISLR2
immunoglobulin superfamily containing leucine-rich repeat 2
chr20_-_39766522 13.431


chr19_+_58095507 12.979 NM_001010879
ZIK1
zinc finger protein interacting with K protein 1 homolog (mouse)
chr11_+_57365577 12.927 NM_001032295
SERPING1
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
chr19_+_37407230 12.452 NM_001204835
NM_001204836
NM_001204837
NM_001204838
NM_001204839
NM_198539
ZNF568





zinc finger protein 568





chr15_+_74422742 12.147 NM_020851
ISLR2
immunoglobulin superfamily containing leucine-rich repeat 2
chr2_+_189839132 11.784 COL3A1
collagen, type III, alpha 1
chr11_+_117070039 11.771 NM_001001522
NM_003186
TAGLN

transgelin

chr16_+_58283819 11.751 NM_001142302
NM_014157
CCDC113

coiled-coil domain containing 113

chr1_+_153330329 11.138 NM_002965
S100A9
S100 calcium binding protein A9
chr19_+_57752051 11.107 NM_001023563
NM_001145078
ZNF805

zinc finger protein 805

chrX_+_117480416 9.887 WDR44
WD repeat domain 44
chr4_-_88450243 9.708 SPARCL1
SPARC-like 1 (hevin)
chr8_-_27941387 9.665 NM_001010906
C8orf80
chromosome 8 open reading frame 80
chr1_+_196788860 9.538 NM_002113
CFHR1
complement factor H-related 1
chr11_-_124543598 9.357 NM_170601
SIAE
sialic acid acetylesterase
chr2_+_189839113 9.319 COL3A1
collagen, type III, alpha 1
chr1_-_203320249 9.319


chr12_-_15038724 8.967 NM_000900
NM_001190839
MGP

matrix Gla protein

chr2_-_79315118 8.951 NM_006507
REG1B
regenerating islet-derived 1 beta
chr14_+_23299102 8.915 MRPL52
mitochondrial ribosomal protein L52
chr10_-_44880452 8.695 NM_000609
NM_001033886
NM_001178134
NM_199168
CXCL12



chemokine (C-X-C motif) ligand 12



chr5_+_79783799 8.684 NM_205548
FAM151B
family with sequence similarity 151, member B
chr2_+_189839078 8.591 NM_000090
COL3A1
collagen, type III, alpha 1
chr19_+_859658 8.574 NM_001928
CFD
complement factor D (adipsin)
chr14_+_23299083 8.497 NM_178336
NM_180982
NM_181304
NM_181305
NM_181306
NM_181307
MRPL52





mitochondrial ribosomal protein L52





chr15_-_90347534 8.477 ANPEP
alanyl (membrane) aminopeptidase
chr10_-_90712510 8.460 NM_001613
ACTA2
actin, alpha 2, smooth muscle, aorta
chr14_+_101292483 8.201


chr11_+_113930430 8.102 NM_006006
ZBTB16
zinc finger and BTB domain containing 16
chr15_+_74422589 8.088 NM_001130138
ISLR2
immunoglobulin superfamily containing leucine-rich repeat 2
chr14_+_101292451 7.906 MEG3
maternally expressed 3 (non-protein coding)
chr1_-_203320185 7.883 FMOD
fibromodulin
chr19_+_41509825 7.831 CYP2B6
cytochrome P450, family 2, subfamily B, polypeptide 6
chr12_-_99038401 7.774 NM_153687
NM_201612
NM_201613
IKBIP


IKBKB interacting protein


chr20_-_43883183 7.715 NM_003064
SLPI
secretory leukocyte peptidase inhibitor
chr3_-_49158171 7.603 USP19
ubiquitin specific peptidase 19
chr17_+_41857802 7.586 NM_001136483
C17orf105
chromosome 17 open reading frame 105
chr14_+_55034633 7.418 SAMD4A
sterile alpha motif domain containing 4A
chr16_+_69166538 7.382 CIRH1A
cirrhosis, autosomal recessive 1A (cirhin)
chr3_-_49158256 7.325 USP19
ubiquitin specific peptidase 19
chr7_-_99573637 7.259 NM_001185
AZGP1
alpha-2-glycoprotein 1, zinc-binding
chr12_+_54332575 7.199 NM_017410
HOXC13
homeobox C13
chr3_-_49158357 7.131 NM_001199160
NM_001199161
NM_001199162
NM_006677
USP19



ubiquitin specific peptidase 19



chr9_-_79520878 7.123 NM_015225
PRUNE2
prune homolog 2 (Drosophila)
chr1_-_220445747 7.115 RAB3GAP2
RAB3 GTPase activating protein subunit 2 (non-catalytic)
chr1_-_161279724 7.113 NM_000530
MPZ
myelin protein zero
chr1_+_15764934 7.079 NM_007272
CTRC
chymotrypsin C (caldecrin)
chr4_-_25032306 7.074 NM_018176
LGI2
leucine-rich repeat LGI family, member 2
chr4_-_46911223 7.055 NM_130902
COX7B2
cytochrome c oxidase subunit VIIb2
chr1_-_154193044 7.042 C1orf43
chromosome 1 open reading frame 43
chr2_+_10183630 6.947 NM_003597
NM_001177716
KLF11

Kruppel-like factor 11

chr19_-_6720585 6.918 NM_000064
C3
complement component 3
chr19_+_859673 6.771 CFD
complement factor D (adipsin)
chr6_-_32557431 6.757 NM_001243965
NM_002124
HLA-DRB1

HLA-DRB4
HLA-DRB5
major histocompatibility complex, class II, DR beta 1

major histocompatibility complex, class II, DR beta 4
major histocompatibility complex, class II, DR beta 5
chr12_-_91505215 6.700 LUM
lumican
chr16_+_55512801 6.693 NM_004530
MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
chr2_-_234475400 6.665 USP40
ubiquitin specific peptidase 40
chr14_+_76618289 6.604 C14orf118
chromosome 14 open reading frame 118
chr3_+_10068123 6.520 FANCD2
Fanconi anemia, complementation group D2
chr1_-_79472360 6.410 NM_022159
ELTD1
EGF, latrophilin and seven transmembrane domain containing 1
chr16_-_72206023 6.351 NM_031293
PMFBP1
polyamine modulated factor 1 binding protein 1
chr8_+_133879202 6.309 NM_003235
TG
thyroglobulin
chr16_+_30386097 6.295 NM_013292
MYLPF
myosin light chain, phosphorylatable, fast skeletal muscle
chr2_+_79347487 6.247 NM_002909
REG1A
regenerating islet-derived 1 alpha
chr8_+_80523376 6.188 STMN2
stathmin-like 2
chr8_+_80523339 6.182 STMN2
stathmin-like 2
chr2_-_160568837 6.133 BAZ2B
bromodomain adjacent to zinc finger domain, 2B
chr8_+_80523304 6.098 STMN2
stathmin-like 2
chr19_+_52264452 6.090 NM_001005738
FPR2
formyl peptide receptor 2
chr8_+_80523351 6.062 STMN2
stathmin-like 2
chr14_-_25078818 6.024 NM_033423
GZMH
granzyme H (cathepsin G-like 2, protein h-CCPX)
chr10_-_99205742 5.966 NM_016046
EXOSC1
exosome component 1
chr6_+_33043702 5.908 NM_002121
HLA-DPB1
major histocompatibility complex, class II, DP beta 1
chr3_+_10068097 5.866 NM_001018115
NM_033084
FANCD2

Fanconi anemia, complementation group D2

chr21_+_35736322 5.849 NM_172201
KCNE2
potassium voltage-gated channel, Isk-related family, member 2
chr12_+_32112286 5.779 NM_018169
C12orf35
chromosome 12 open reading frame 35
chr7_-_97881436 5.755 NM_015395
TECPR1
tectonin beta-propeller repeat containing 1
chr1_-_153029987 5.733 NM_005988
SPRR2A
small proline-rich protein 2A
chr3_-_46506342 5.712 NM_002343
LTF
lactotransferrin
chr1_+_1370902 5.684 NM_022834
NM_199121
VWA1

von Willebrand factor A domain containing 1

chr16_+_75252882 5.682 NM_001906
CTRB1
chymotrypsinogen B1
chr18_+_21572736 5.666 NM_153211
TTC39C
tetratricopeptide repeat domain 39C
chr10_-_47173917 5.657 NM_001040084
NM_001098845
ANXA8L2
ANXA8
ANXA8L1
annexin A8-like 2
annexin A8
annexin A8-like 1
chr14_+_76618244 5.652 NM_017926
NM_017972
C14orf118

chromosome 14 open reading frame 118

chr6_-_31125960 5.626 NM_019052
CCHCR1
coiled-coil alpha-helical rod protein 1
chr10_-_75401492 5.578 NM_021245
MYOZ1
myozenin 1
chr9_-_115480363 5.544 NM_021218
C9orf80
chromosome 9 open reading frame 80
chr6_+_32407618 5.523 NM_019111
HLA-DRA
major histocompatibility complex, class II, DR alpha
chr1_-_203055088 5.445 MYOG
myogenin (myogenic factor 4)
chr6_-_99873129 5.411 NM_015491
NM_032870
PNISR

PNN-interacting serine/arginine-rich protein

chr9_-_130477918 5.401 NM_001002913
PTRH1
peptidyl-tRNA hydrolase 1 homolog (S. cerevisiae)
chr5_+_134240820 5.386 PCBD2
pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2
chr4_+_74270832 5.386 ALB
albumin
chr19_+_17186569 5.375 NM_001130065
NM_004145
MYO9B

myosin IXB

chr21_-_46340776 5.361 ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr12_-_48551269 5.352 NM_024095
ASB8
ankyrin repeat and SOCS box containing 8
chr5_-_140012730 5.340 CD14
CD14 molecule
chr3_+_186330844 5.328 NM_001622
AHSG
alpha-2-HS-glycoprotein
chr19_-_36236291 5.269 NM_001040425
NM_144987
U2AF1L4

U2 small nuclear RNA auxiliary factor 1-like 4

chr10_-_74114655 5.265 DNAJB12
DnaJ (Hsp40) homolog, subfamily B, member 12
chr1_+_160765927 5.263 NM_001033667
NM_002348
LY9

lymphocyte antigen 9

chr1_-_120935893 5.260 FCGR1B
Fc fragment of IgG, high affinity Ib, receptor (CD64)
chr7_-_43909072 5.256 NM_032014
MRPS24
mitochondrial ribosomal protein S24
chr3_+_186330711 5.252 AHSG
alpha-2-HS-glycoprotein
chr11_-_64510461 5.217 RASGRP2
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
chr3_+_186330859 5.207 AHSG
alpha-2-HS-glycoprotein
chr1_-_114429996 5.189 BCL2L15
BCL2-like 15
chr14_+_76618272 5.164 C14orf118
chromosome 14 open reading frame 118
chr6_-_32497925 5.144 NM_002125
HLA-DRB5
major histocompatibility complex, class II, DR beta 5
chr21_-_46340821 5.144 ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr19_+_33685489 5.124 NM_002333
LRP3
low density lipoprotein receptor-related protein 3
chr1_-_1709863 5.116 NM_023018
NADK
NAD kinase
chr19_+_12721731 5.098 NM_153358
ZNF791
zinc finger protein 791
chr1_-_203320287 5.085 NM_002023
FMOD
fibromodulin
chr17_-_43568081 5.064 PLEKHM1
pleckstrin homology domain containing, family M (with RUN domain) member 1
chr20_+_42839599 5.051 LOC100505783
uncharacterized LOC100505783
chr1_+_145438437 5.037 NM_006472
TXNIP
thioredoxin interacting protein
chr17_-_43138311 4.999 NM_024819
DCAKD
dephospho-CoA kinase domain containing
chr19_+_16999871 4.992 F2RL3
coagulation factor II (thrombin) receptor-like 3
chr6_+_99872769 4.966


chr7_+_80267972 4.962 CD36
CD36 molecule (thrombospondin receptor)
chr11_-_64510339 4.939 RASGRP2
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
chrX_+_11311532 4.938 NM_001142
NM_182680
NM_182681
AMELX


amelogenin, X-linked


chr20_-_35274557 4.924 NM_032214
NM_175077
SLA2

Src-like-adaptor 2

chr14_-_21271002 4.914 NM_002933
NM_198234
NM_198235
RNASE1


ribonuclease, RNase A family, 1 (pancreatic)


chr10_-_115933884 4.912 C10orf118
chromosome 10 open reading frame 118
chr1_-_151762905 4.869 NM_001083963
NM_001083964
NM_001083965
NM_006862
TDRKH



tudor and KH domain containing



chr9_+_132427919 4.821 NM_016307
PRRX2
paired related homeobox 2
chr10_+_49609641 4.802 NM_002750
NM_139046
NM_139047
NM_139049
MAPK8



mitogen-activated protein kinase 8



chr10_-_75401199 4.800 MYOZ1
myozenin 1
chr1_-_161519526 4.798 FCGR3A
Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
chr1_+_33004771 4.794 NM_001040441
ZBTB8A
zinc finger and BTB domain containing 8A
chr2_+_79347610 4.755 REG1A
regenerating islet-derived 1 alpha
chr9_-_88969323 4.728 NM_001185059
NM_001185074
NM_024617
ZCCHC6


zinc finger, CCHC domain containing 6


chr16_+_29674564 4.724 SPN
sialophorin
chr5_-_157002705 4.714


chr10_-_33623299 4.709 NRP1
neuropilin 1
chr1_-_32169555 4.709 COL16A1
collagen, type XVI, alpha 1
chr11_+_2323356 4.692 TSPAN32
tetraspanin 32
chr1_+_36689996 4.692 NM_005119
THRAP3
thyroid hormone receptor associated protein 3
chr5_-_39270708 4.675 NM_001243093
FYB
FYN binding protein
chr2_-_218843541 4.660 TNS1
tensin 1
chr12_+_32654976 4.654 NM_139241
FGD4
FYVE, RhoGEF and PH domain containing 4
chr1_-_31230594 4.651 LAPTM5
lysosomal protein transmembrane 5
chr8_+_17434700 4.644 PDGFRL
platelet-derived growth factor receptor-like
chr6_+_37137882 4.641 NM_001243186
NM_002648
PIM1

pim-1 oncogene

chr9_-_129870311 4.629 ANGPTL2
angiopoietin-like 2
chr1_+_16174358 4.621 NM_015001
SPEN
spen homolog, transcriptional regulator (Drosophila)
chr18_+_49867069 4.607 DCC
deleted in colorectal carcinoma
chr19_+_11457160 4.562 NM_001080503
CCDC159
coiled-coil domain containing 159
chr7_-_38389424 4.561


chr17_+_47653474 4.559 NXPH3
neurexophilin 3
chr14_-_106110894 4.535 IGHG2
immunoglobulin heavy constant gamma 2 (G2m marker)
chr16_-_72206348 4.535 NM_001160213
PMFBP1
polyamine modulated factor 1 binding protein 1
chr7_-_108166514 4.534 PNPLA8
patatin-like phospholipase domain containing 8
chrX_-_65858882 4.477 NM_021783
EDA2R
ectodysplasin A2 receptor
chr4_-_155533757 4.477 FGG
fibrinogen gamma chain
chr1_-_1590403 4.467 CDK11A
CDK11B
cyclin-dependent kinase 11A
cyclin-dependent kinase 11B
chr14_+_35515347 4.467 NM_173607
FAM177A1
family with sequence similarity 177, member A1
chr6_-_116422408 4.464


chr8_+_22210311 4.453 PIWIL2
piwi-like 2 (Drosophila)
chr17_+_74734106 4.448 MFSD11
major facilitator superfamily domain containing 11
chr3_-_114343791 4.444 NM_001164346
ZBTB20
zinc finger and BTB domain containing 20
chr17_-_46667596 4.444 HOXB3
homeobox B3
chr3_+_9404706 4.394 NM_001114092
NM_015453
THUMPD3

THUMP domain containing 3

chr7_-_44105162 4.385 NM_000290
PGAM2
phosphoglycerate mutase 2 (muscle)
chr15_-_77197743 4.363 SCAPER
S-phase cyclin A-associated protein in the ER
chrX_+_67867510 4.354 NM_001142503
NM_014725
STARD8

StAR-related lipid transfer (START) domain containing 8

chrX_+_15518899 4.352 NM_203281
BMX
BMX non-receptor tyrosine kinase
chr4_-_155533800 4.341 FGG
fibrinogen gamma chain
chr9_-_129884885 4.333 ANGPTL2
angiopoietin-like 2
chr9_+_88897112 4.331


chr21_-_46340874 4.326 NM_000211
ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr9_+_100395704 4.294 NM_002486
NCBP1
nuclear cap binding protein subunit 1, 80kDa
chr3_-_114343052 4.291 NM_001164347
ZBTB20
zinc finger and BTB domain containing 20
chr17_-_43568124 4.289 NM_014798
PLEKHM1
pleckstrin homology domain containing, family M (with RUN domain) member 1
chr2_+_149633173 4.282


chr14_-_53417272 4.271 FERMT2
fermitin family member 2
chr7_+_135347211 4.261 NM_001130929
SLC13A4
C7orf73
solute carrier family 13 (sodium/sulfate symporters), member 4
chromosome 7 open reading frame 73
chr19_-_52133589 4.253 NM_003830
SIGLEC5
sialic acid binding Ig-like lectin 5
chr14_+_70233880 4.240 SRSF5
serine/arginine-rich splicing factor 5
chr6_+_36410800 4.239 KCTD20
potassium channel tetramerisation domain containing 20
chr12_+_120105656 4.238 NM_006253
PRKAB1
protein kinase, AMP-activated, beta 1 non-catalytic subunit
chr19_+_34112854 4.237 NM_001127895
NM_001127896
CHST8

carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8

chr21_+_43639202 4.230 NM_004915
NM_016818
ABCG1

ATP-binding cassette, sub-family G (WHITE), member 1

chr19_-_38806546 4.214 NM_001039672
NM_001039673
NM_001145463
YIF1B


Yip1 interacting factor homolog B (S. cerevisiae)


chr1_-_157522151 4.200 NM_001195388
NM_031281
FCRL5

Fc receptor-like 5

chr8_+_21915371 4.195 NM_001114135
EPB49
erythrocyte membrane protein band 4.9 (dematin)
chr10_+_48255223 4.189 NM_001040084
NM_001098845
ANXA8L2
ANXA8
ANXA8L1
annexin A8-like 2
annexin A8
annexin A8-like 1
chr4_+_88754120 4.165 NM_001184695
NM_001184696
NM_001184697
NM_020203
MEPE



matrix extracellular phosphoglycoprotein



chr22_-_41032623 4.157 MKL1
megakaryoblastic leukemia (translocation) 1
chr12_-_110271182 4.151 TRPV4
transient receptor potential cation channel, subfamily V, member 4
chr19_+_12305869 4.133



Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.27 2.28e-17 GO:0065007 biological regulation
1.47 1.13e-12 GO:0048856 anatomical structure development
1.25 1.14e-12 GO:0050789 regulation of biological process
1.44 2.77e-12 GO:0007275 multicellular organismal development
1.40 6.52e-12 GO:0032502 developmental process
1.49 6.61e-12 GO:0048731 system development
1.77 3.82e-11 GO:0002376 immune system process
1.48 6.45e-11 GO:0048518 positive regulation of biological process
1.30 1.96e-10 GO:0032501 multicellular organismal process
1.94 2.67e-09 GO:0006955 immune response
1.23 7.43e-09 GO:0050794 regulation of cellular process
1.52 7.31e-08 GO:0048583 regulation of response to stimulus
1.51 1.32e-07 GO:0048513 organ development
1.23 4.89e-07 GO:0050896 response to stimulus
1.46 8.06e-07 GO:0048869 cellular developmental process
1.12 8.59e-07 GO:0009987 cellular process
1.46 1.69e-06 GO:0030154 cell differentiation
1.31 2.02e-06 GO:0023052 signaling
1.82 4.81e-06 GO:0002682 regulation of immune system process
1.52 8.43e-06 GO:0009653 anatomical structure morphogenesis
2.00 2.02e-05 GO:0002684 positive regulation of immune system process
1.38 2.47e-05 GO:0048522 positive regulation of cellular process
1.40 2.64e-05 GO:0042221 response to chemical stimulus
1.74 3.20e-05 GO:2000026 regulation of multicellular organismal development
1.55 3.62e-05 GO:0051239 regulation of multicellular organismal process
1.40 6.75e-05 GO:0065008 regulation of biological quality
1.95 7.04e-05 GO:0050776 regulation of immune response
1.81 8.98e-05 GO:0009887 organ morphogenesis
1.30 1.04e-04 GO:0007165 signal transduction
1.64 1.18e-04 GO:0009611 response to wounding
1.68 1.23e-04 GO:0048584 positive regulation of response to stimulus
1.26 1.37e-04 GO:0051716 cellular response to stimulus
2.33 2.16e-04 GO:0002253 activation of immune response
2.16 2.33e-04 GO:0050778 positive regulation of immune response
1.47 2.39e-04 GO:0007399 nervous system development
1.60 6.15e-04 GO:0050793 regulation of developmental process
1.61 1.53e-03 GO:0006952 defense response
1.55 1.92e-03 GO:0009605 response to external stimulus
1.93 1.96e-03 GO:0045087 innate immune response
5.51 2.98e-03 GO:0003156 regulation of organ formation
1.48 4.02e-03 GO:0010604 positive regulation of macromolecule metabolic process
2.18 4.83e-03 GO:0051249 regulation of lymphocyte activation
2.09 5.15e-03 GO:0050865 regulation of cell activation
1.61 5.77e-03 GO:0010557 positive regulation of macromolecule biosynthetic process
1.59 8.16e-03 GO:0007267 cell-cell signaling
1.72 1.04e-02 GO:0006935 chemotaxis
1.72 1.04e-02 GO:0042330 taxis
2.08 1.04e-02 GO:0002694 regulation of leukocyte activation
3.11 1.05e-02 GO:2000027 regulation of organ morphogenesis
1.44 1.10e-02 GO:0009893 positive regulation of metabolic process
1.30 1.15e-02 GO:0006950 response to stress
1.43 1.55e-02 GO:0010033 response to organic substance
1.52 1.60e-02 GO:0022008 neurogenesis
1.53 1.76e-02 GO:0009891 positive regulation of biosynthetic process
1.60 1.76e-02 GO:0030182 neuron differentiation
3.35 1.85e-02 GO:0019724 B cell mediated immunity
2.21 2.19e-02 GO:0002764 immune response-regulating signaling pathway
1.22 2.42e-02 GO:0019222 regulation of metabolic process
1.52 2.63e-02 GO:0040011 locomotion
2.16 2.74e-02 GO:0007517 muscle organ development
1.34 2.82e-02 GO:0007166 cell surface receptor linked signaling pathway
1.90 3.32e-02 GO:0022603 regulation of anatomical structure morphogenesis
2.19 3.36e-02 GO:0002757 immune response-activating signal transduction
2.22 3.47e-02 GO:0010038 response to metal ion
2.23 4.07e-02 GO:0001654 eye development
1.68 4.64e-02 GO:0000904 cell morphogenesis involved in differentiation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.63 2.47e-16 GO:0044459 plasma membrane part
1.78 6.99e-13 GO:0005887 integral to plasma membrane
1.77 1.11e-12 GO:0031226 intrinsic to plasma membrane
1.86 1.33e-12 GO:0044421 extracellular region part
1.54 3.33e-11 GO:0005576 extracellular region
1.86 1.73e-09 GO:0005615 extracellular space
1.31 5.72e-09 GO:0005886 plasma membrane
1.31 7.30e-09 GO:0071944 cell periphery
2.26 8.08e-09 GO:0031012 extracellular matrix
2.16 3.79e-06 GO:0005578 proteinaceous extracellular matrix
1.97 9.68e-04 GO:0015629 actin cytoskeleton
3.27 9.95e-04 GO:0016459 myosin complex
2.15 1.65e-03 GO:0030141 stored secretory granule
3.29 3.11e-03 GO:0031091 platelet alpha granule
6.30 3.42e-03 GO:0042613 MHC class II protein complex
3.39 3.68e-03 GO:0031983 vesicle lumen
5.51 3.87e-03 GO:0032982 myosin filament
2.32 6.32e-03 GO:0009897 external side of plasma membrane
2.54 6.58e-03 GO:0005924 cell-substrate adherens junction
2.56 8.73e-03 GO:0005925 focal adhesion
3.31 9.78e-03 GO:0060205 cytoplasmic membrane-bounded vesicle lumen
2.45 1.28e-02 GO:0030055 cell-substrate junction
2.14 1.31e-02 GO:0070161 anchoring junction
3.28 1.98e-02 GO:0031093 platelet alpha granule lumen
1.56 2.12e-02 GO:0030054 cell junction
3.22 2.57e-02 GO:0034774 secretory granule lumen
1.45 3.09e-02 GO:0005626 insoluble fraction
4.90 3.57e-02 GO:0005859 muscle myosin complex

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.58 2.81e-05 GO:0005102 receptor binding
1.09 1.79e-04 GO:0005488 binding
1.15 4.29e-04 GO:0005515 protein binding
1.83 1.22e-02 GO:0003779 actin binding
5.51 2.20e-02 GO:0000146 microfilament motor activity
5.51 2.20e-02 GO:0019865 immunoglobulin binding