Motif ID: XBP1.p3

Z-value: 3.726


Transcription factors associated with XBP1.p3:

Gene SymbolEntrez IDGene Name
XBP1 7494 X-box binding protein 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
XBP1chr22_-_291965370.497.2e-15Click!


Activity profile for motif XBP1.p3.

activity profile for motif XBP1.p3


Sorted Z-values histogram for motif XBP1.p3

Sorted Z-values for motif XBP1.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of XBP1.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_+_171758289 148.665 NM_001135095
FNDC3B
fibronectin type III domain containing 3B
chr3_-_57583080 129.257 ARF4
ADP-ribosylation factor 4
chr7_-_6523689 108.154 NM_001100603
NM_006854
KDELR2

KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2

chr3_-_57582866 103.965 ARF4
ADP-ribosylation factor 4
chr3_-_57583090 101.055 ARF4
ADP-ribosylation factor 4
chr2_-_69614321 99.375 NM_001244710
NM_002056
GFPT1

glutamine--fructose-6-phosphate transaminase 1

chr6_-_7910716 96.791 NM_030810
TXNDC5
thioredoxin domain containing 5 (endoplasmic reticulum)
chr1_-_43736600 95.112 EBNA1BP2
EBNA1 binding protein 2
chr6_-_7910278 94.470 NM_001145549
TXNDC5
thioredoxin domain containing 5 (endoplasmic reticulum)
chr3_-_57583153 90.534 NM_001660
ARF4
ADP-ribosylation factor 4
chr7_+_128379345 88.452 NM_001130674
NM_001199671
NM_001199672
NM_001199673
NM_001199674
NM_001219
CALU





calumenin





chr15_+_79603427 87.183 NM_007364
TMED3
transmembrane emp24 protein transport domain containing 3
chr15_+_79603497 86.420 TMED3
transmembrane emp24 protein transport domain containing 3
chr3_+_133524671 80.540 SRPRB
signal recognition particle receptor, B subunit
chr15_-_60690115 79.251 NM_001002857
NM_001002858
NM_001136015
NM_004039
ANXA2



annexin A2



chr3_+_133524636 76.326 SRPRB
signal recognition particle receptor, B subunit
chr12_-_106641675 74.922 NM_006825
CKAP4
cytoskeleton-associated protein 4
chr3_+_127771287 73.237 SEC61A1
Sec61 alpha 1 subunit (S. cerevisiae)
chr7_+_128379400 69.663 CALU
calumenin
chr7_-_54826864 68.085 SEC61G
Sec61 gamma subunit
chr7_+_128379428 67.323 CALU
calumenin
chr7_+_128379452 67.220 CALU
calumenin
chr7_+_128379395 66.641 CALU
calumenin
chr1_-_24126031 66.119 NM_001127621
GALE
UDP-galactose-4-epimerase
chr2_+_171785624 60.017 GORASP2
golgi reassembly stacking protein 2, 55kDa
chr5_-_10761344 57.758 NM_004394
DAP
death-associated protein
chr11_-_66056607 56.783 NM_020470
YIF1A
Yip1 interacting factor homolog A (S. cerevisiae)
chr5_-_131563481 55.116 NM_001017974
NM_001142598
NM_001142599
P4HA2


prolyl 4-hydroxylase, alpha polypeptide II


chr2_+_171785780 54.987 GORASP2
golgi reassembly stacking protein 2, 55kDa
chr3_+_100428393 54.896 TFG
TRK-fused gene
chr5_-_10761341 54.534 DAP
death-associated protein
chr7_+_94023872 54.170 NM_000089
COL1A2
collagen, type I, alpha 2
chr11_+_17298278 53.836 NM_005013
NUCB2
nucleobindin 2
chr11_-_66056455 51.684 YIF1A
Yip1 interacting factor homolog A (S. cerevisiae)
chr3_-_128369525 51.045 RPN1
ribophorin I
chr5_-_10761179 50.924 DAP
death-associated protein
chr2_-_20251788 50.507 NM_014713
LAPTM4A
lysosomal protein transmembrane 4 alpha
chr12_+_124069053 50.468 NM_006815
TMED2
transmembrane emp24 domain trafficking protein 2
chr5_-_121414011 49.159 NM_002317
LOX
lysyl oxidase
chr5_+_115177616 48.136 NM_001284
AP3S1
adaptor-related protein complex 3, sigma 1 subunit
chr2_-_33824294 48.100 NM_015475
FAM98A
family with sequence similarity 98, member A
chr11_+_61560352 47.833 FEN1
flap structure-specific endonuclease 1
chr14_-_24664758 47.398 NM_001014842
NM_006405
TM9SF1

transmembrane 9 superfamily member 1

chr14_-_24664606 47.046 TM9SF1
transmembrane 9 superfamily member 1
chr6_-_108279307 45.959 SEC63
SEC63 homolog (S. cerevisiae)
chr6_-_108279320 45.513 SEC63
SEC63 homolog (S. cerevisiae)
chr3_+_100428133 44.716 NM_001007565
NM_001195479
NM_006070
TFG


TRK-fused gene


chr16_-_75529278 44.353


chr10_+_89419352 43.972 NM_001015880
NM_004670
PAPSS2

3'-phosphoadenosine 5'-phosphosulfate synthase 2

chr11_+_61560108 43.808 NM_004111
FEN1
flap structure-specific endonuclease 1
chr14_-_39572414 43.324 NM_006364
SEC23A
Sec23 homolog A (S. cerevisiae)
chr12_+_124069099 42.806 TMED2
transmembrane emp24 domain trafficking protein 2
chr11_+_32112414 42.097 NM_002901
RCN1
reticulocalbin 1, EF-hand calcium binding domain
chr5_-_137088952 41.537 HNRNPA0
heterogeneous nuclear ribonucleoprotein A0
chr9_+_100818941 41.425 NM_018946
NANS
N-acetylneuraminic acid synthase
chr2_-_242212244 41.203 NM_001243900
NM_203346
HDLBP

high density lipoprotein binding protein

chr1_+_161123755 41.143 UFC1
ubiquitin-fold modifier conjugating enzyme 1
chr21_-_18985104 40.952 BTG3
BTG family, member 3
chr7_-_54826899 40.823 NM_001012456
NM_014302
SEC61G

Sec61 gamma subunit

chr11_-_118927872 40.808 NM_006389
NM_001130991
HYOU1

hypoxia up-regulated 1

chr6_-_109703553 40.056 CD164
CD164 molecule, sialomucin
chrX_+_153060073 39.754 SSR4
signal sequence receptor, delta
chr11_+_69455938 39.225 CCND1
cyclin D1
chr11_-_61560052 38.876 NM_014206
C11orf10
chromosome 11 open reading frame 10
chr4_+_38869346 38.531 NM_138389
FAM114A1
family with sequence similarity 114, member A1
chr12_+_124069080 38.426 TMED2
transmembrane emp24 domain trafficking protein 2
chr8_-_124054491 38.368 DERL1
Der1-like domain family, member 1
chr14_+_52456322 38.270 C14orf166
chromosome 14 open reading frame 166
chr11_-_118927851 37.234 HYOU1
hypoxia up-regulated 1
chr1_-_11120001 37.109 SRM
spermidine synthase
chr17_-_40575117 36.992 NM_012232
PTRF
polymerase I and transcript release factor
chr17_+_15848230 36.751 NM_000676
ADORA2B
adenosine A2b receptor
chr20_+_44044706 36.133 NM_001184728
NM_001184729
NM_001184730
NM_015937
PIGT



phosphatidylinositol glycan anchor biosynthesis, class T



chr21_-_18985224 36.116 NM_001130914
NM_006806
BTG3

BTG family, member 3

chr14_+_52456192 35.738 NM_016039
C14orf166
chromosome 14 open reading frame 166
chr18_+_34409058 35.221 NM_020776
KIAA1328
KIAA1328
chr14_-_50087326 35.165 NM_001001
RPL36AL
ribosomal protein L36a-like
chr1_-_87379784 34.254 SEP15
15 kDa selenoprotein
chr1_-_87379808 33.901 SEP15
15 kDa selenoprotein
chr11_+_32605337 33.575 EIF3M
eukaryotic translation initiation factor 3, subunit M
chrX_+_153059903 33.249 NM_001204526
NM_006280
SSR4

signal sequence receptor, delta

chr2_+_85132762 32.984 NM_021103
TMSB10
thymosin beta 10
chr10_-_120840296 32.963 EIF3A
eukaryotic translation initiation factor 3, subunit A
chr21_-_18985189 32.482 BTG3
BTG family, member 3
chr3_+_33155447 32.131 NM_006371
CRTAP
cartilage associated protein
chr3_+_100428361 32.077 NM_001195478
TFG
TRK-fused gene
chrX_+_153059629 32.058 NM_001204527
SSR4
signal sequence receptor, delta
chr1_-_11120076 31.833 SRM
spermidine synthase
chr11_+_32112607 31.697 RCN1
reticulocalbin 1, EF-hand calcium binding domain
chr6_+_33168602 31.608 NM_001077516
NM_006979
SLC39A7

solute carrier family 39 (zinc transporter), member 7

chr20_+_31407696 31.579 NM_012325
MAPRE1
microtubule-associated protein, RP/EB family, member 1
chr3_+_122785855 31.549 NM_006810
PDIA5
protein disulfide isomerase family A, member 5
chr11_-_118927815 31.413 HYOU1
hypoxia up-regulated 1
chr7_-_30066124 31.262 NM_017946
FKBP14
FK506 binding protein 14, 22 kDa
chr1_-_11120081 31.045 NM_003132
SRM
spermidine synthase
chr1_-_45988561 30.839 NM_001202431
PRDX1
peroxiredoxin 1
chr10_-_71930185 30.418 NM_001142648
NM_020150
SAR1A

SAR1 homolog A (S. cerevisiae)

chr8_-_124054540 29.533 DERL1
Der1-like domain family, member 1
chr1_-_11120047 29.478 SRM
spermidine synthase
chr13_-_31040035 29.050 NM_002128
HMGB1
high mobility group box 1
chr11_+_118443140 28.967 ARCN1
archain 1
chr1_+_228270429 28.788 ARF1
ADP-ribosylation factor 1
chr4_-_119757183 28.722 SEC24D
SEC24 family, member D (S. cerevisiae)
chr9_-_35732226 28.449 TLN1
talin 1
chr2_+_85132999 28.414 TMSB10
thymosin beta 10
chr2_+_242254722 28.109 NM_001008491
NM_006155
SEPT2

septin 2

chr11_+_61560401 28.024 FEN1
flap structure-specific endonuclease 1
chr19_-_29704021 27.619 UQCRFS1
ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
chr2_-_20251400 27.538 LAPTM4A
lysosomal protein transmembrane 4 alpha
chr1_+_110527327 27.465 NM_001242673
NM_006621
AHCYL1

adenosylhomocysteinase-like 1

chr8_-_124054591 27.228 NM_001134671
NM_024295
DERL1

Der1-like domain family, member 1

chrX_+_67718868 26.888 YIPF6
Yip1 domain family, member 6
chr10_-_98346594 26.812 TM9SF3
transmembrane 9 superfamily member 3
chr9_+_114393543 26.513 NM_001015882
NM_004125
DNAJC25
DNAJC25-GNG10
DnaJ (Hsp40) homolog, subfamily C , member 25
DNAJC25-GNG10 readthrough
chr11_-_62414086 26.485 GANAB
glucosidase, alpha; neutral AB
chr18_-_47018842 26.353 NM_001199356
NM_000985
NM_001035006
NM_001199340
NM_001199345
RPL17-C18ORF32
RPL17



RPL17-C18orf32 readthrough
ribosomal protein L17



chr2_-_242254984 26.215 HDLBP
high density lipoprotein binding protein
chr6_-_90062349 26.141 UBE2J1
ubiquitin-conjugating enzyme E2, J1, U
chr6_+_30294224 26.040


chr18_-_47018777 25.954 RPL17
ribosomal protein L17
chr6_+_116692098 25.824 NM_013352
DSE
dermatan sulfate epimerase
chr18_-_47018822 25.752 NM_001199341
NM_001199342
NM_001199343
NM_001199344
RPL17



ribosomal protein L17



chr1_+_87170486 25.604 SH3GLB1
SH3-domain GRB2-like endophilin B1
chr17_+_15848422 25.558 ADORA2B
adenosine A2b receptor
chr21_+_42539727 25.497 NM_012105
NM_138991
NM_138992
BACE2


beta-site APP-cleaving enzyme 2


chr13_-_31039966 25.044 HMGB1
high mobility group box 1
chr11_-_118972529 24.975 DPAGT1
dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase)
chr11_+_118443091 24.768 NM_001142281
NM_001655
ARCN1

archain 1

chr4_-_119757288 24.651 NM_014822
SEC24D
SEC24 family, member D (S. cerevisiae)
chr19_-_29704107 24.352 NM_006003
UQCRFS1
ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
chr15_+_44038483 24.217 NM_005313
PDIA3
protein disulfide isomerase family A, member 3
chr11_-_62414063 24.001 GANAB
glucosidase, alpha; neutral AB
chr15_+_44038649 23.607 PDIA3
protein disulfide isomerase family A, member 3
chr11_-_62414096 23.456 NM_198334
NM_198335
GANAB

glucosidase, alpha; neutral AB

chr17_+_37026309 23.408 LASP1
LIM and SH3 protein 1
chrX_+_77359665 23.127 NM_000291
PGK1
phosphoglycerate kinase 1
chr2_-_20251280 23.010 LAPTM4A
lysosomal protein transmembrane 4 alpha
chr2_+_216176808 22.803 ATIC
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
chr10_-_98346793 22.797 NM_020123
TM9SF3
transmembrane 9 superfamily member 3
chr1_-_87380008 22.706 NM_004261
NM_203341
SEP15

15 kDa selenoprotein

chr5_-_121413906 22.411 LOX
lysyl oxidase
chrX_+_77359768 22.012 PGK1
phosphoglycerate kinase 1
chrX_+_77359754 21.931 PGK1
phosphoglycerate kinase 1
chr12_+_58120029 21.656 LOC100130776
uncharacterized LOC100130776
chr22_-_43253186 21.632 ARFGAP3
ADP-ribosylation factor GTPase activating protein 3
chr12_-_101801499 21.528 NM_001177
ARL1
ADP-ribosylation factor-like 1
chr1_+_110527432 21.338 AHCYL1
adenosylhomocysteinase-like 1
chr2_-_99952779 20.887 NM_005783
TXNDC9
thioredoxin domain containing 9
chr3_-_49395751 20.532 NM_000581
NM_201397
GPX1

glutathione peroxidase 1

chr9_-_35732175 20.422 TLN1
talin 1
chr15_-_90645621 19.989 IDH2
isocitrate dehydrogenase 2 (NADP+), mitochondrial
chr17_+_37026351 19.519 LASP1
LIM and SH3 protein 1
chr9_+_91926109 19.502 NM_001827
CKS2
CDC28 protein kinase regulatory subunit 2
chrX_+_77359712 19.405 PGK1
phosphoglycerate kinase 1
chr12_-_109125289 19.393 NM_014325
CORO1C
coronin, actin binding protein, 1C
chr9_-_35072545 19.367 VCP
valosin containing protein
chr9_+_35732629 19.281 CREB3
cAMP responsive element binding protein 3
chr7_+_94024201 19.084 COL1A2
collagen, type I, alpha 2
chr6_-_90062439 19.034 UBE2J1
ubiquitin-conjugating enzyme E2, J1, U
chr2_+_198365113 18.969 HSPE1
heat shock 10kDa protein 1 (chaperonin 10)
chr19_-_2038937 18.852 MKNK2
MAP kinase interacting serine/threonine kinase 2
chr8_-_81083660 18.522 NM_001025253
NM_005079
TPD52

tumor protein D52

chr11_+_125462751 18.503 STT3A
STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae)
chr9_+_35732498 18.421 CREB3
cAMP responsive element binding protein 3
chr4_-_47916498 18.205 NM_152995
NFXL1
nuclear transcription factor, X-box binding-like 1
chr15_+_44038659 18.026 PDIA3
protein disulfide isomerase family A, member 3
chrX_+_47050208 18.000 UBA1
ubiquitin-like modifier activating enzyme 1
chr1_+_110527307 17.468 AHCYL1
adenosylhomocysteinase-like 1
chr12_+_54718927 17.233 COPZ1
coatomer protein complex, subunit zeta 1
chr6_-_109702902 17.217 CD164
CD164 molecule, sialomucin
chr9_-_35732115 17.132 TLN1
talin 1
chr1_+_87170515 17.097 SH3GLB1
SH3-domain GRB2-like endophilin B1
chr22_-_43253304 17.038 NM_001142293
NM_014570
ARFGAP3

ADP-ribosylation factor GTPase activating protein 3

chr6_+_34204663 17.004 HMGA1
high mobility group AT-hook 1
chr3_-_10362724 16.951 NM_001136232
SEC13
SEC13 homolog (S. cerevisiae)
chr2_+_200819928 16.757 NM_024520
C2orf47
chromosome 2 open reading frame 47
chr12_+_54718910 16.433 NM_016057
COPZ1
coatomer protein complex, subunit zeta 1
chr12_-_92539614 16.350 NM_001731
BTG1
B-cell translocation gene 1, anti-proliferative
chr12_+_54718925 16.279 COPZ1
coatomer protein complex, subunit zeta 1
chr2_+_27255745 16.244 NM_001083590
NM_017727
TMEM214

transmembrane protein 214

chr2_+_27255837 16.230 TMEM214
transmembrane protein 214
chr6_+_7107986 16.132 NM_001003698
NM_001003699
NM_001003700
RREB1


ras responsive element binding protein 1


chr12_-_82752154 15.727 NM_014167
CCDC59
coiled-coil domain containing 59
chr2_-_242212198 15.705 HDLBP
high density lipoprotein binding protein
chr5_+_34656367 15.524 NM_001145522
NM_015577
RAI14

retinoic acid induced 14

chr7_-_128045995 15.345 NM_001142573
NM_001142574
NM_001142575
IMPDH1


IMP (inosine 5'-monophosphate) dehydrogenase 1


chr14_-_39572278 15.250 SEC23A
Sec23 homolog A (S. cerevisiae)
chr11_+_65819803 15.229 NM_006842
SF3B2
splicing factor 3b, subunit 2, 145kDa
chr10_-_16859336 15.040 RSU1
Ras suppressor protein 1
chr9_+_35732207 15.016 NM_006368
CREB3
cAMP responsive element binding protein 3
chr16_-_22385596 14.980 NM_001802
CDR2
cerebellar degeneration-related protein 2, 62kDa
chr6_+_34204690 14.745 HMGA1
high mobility group AT-hook 1
chr20_-_17662828 14.633 NM_001042576
NM_004587
RRBP1

ribosome binding protein 1 homolog 180kDa (dog)

chr15_-_90645709 14.586 IDH2
isocitrate dehydrogenase 2 (NADP+), mitochondrial
chr12_+_57623827 14.394 NM_001166358
NM_001166359
NM_001166357
SHMT2


serine hydroxymethyltransferase 2 (mitochondrial)


chr5_+_149340287 14.379 NM_000112
SLC26A2
solute carrier family 26 (sulfate transporter), member 2
chr5_-_9546157 14.368 NM_003966
SEMA5A
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
chr16_+_66586479 14.057 CKLF
chemokine-like factor
chr19_+_54618789 14.028 NM_015629
PRPF31
PRP31 pre-mRNA processing factor 31 homolog (S. cerevisiae)
chr3_+_127771126 13.921 NM_013336
SEC61A1
Sec61 alpha 1 subunit (S. cerevisiae)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
11.07 6.32e-12 GO:0006487 protein N-linked glycosylation
3.48 1.19e-11 GO:0015031 protein transport
3.41 2.40e-11 GO:0045184 establishment of protein localization
11.22 2.60e-11 GO:0018196 peptidyl-asparagine modification
11.22 2.60e-11 GO:0018279 protein N-linked glycosylation via asparagine
8.53 5.57e-11 GO:0048193 Golgi vesicle transport
3.47 1.74e-10 GO:0046907 intracellular transport
4.74 3.26e-10 GO:0006886 intracellular protein transport
3.00 3.59e-10 GO:0008104 protein localization
2.95 4.37e-10 GO:0051649 establishment of localization in cell
2.78 6.98e-10 GO:0051641 cellular localization
26.81 8.05e-10 GO:0048199 vesicle targeting, to, from or within Golgi
2.13 1.46e-09 GO:0044267 cellular protein metabolic process
1.57 1.65e-09 GO:0044237 cellular metabolic process
1.29 2.07e-09 GO:0009987 cellular process
4.00 3.31e-09 GO:0034613 cellular protein localization
3.98 3.97e-09 GO:0070727 cellular macromolecule localization
6.79 5.54e-09 GO:0043687 post-translational protein modification
22.34 8.00e-09 GO:0006901 vesicle coating
4.20 8.74e-09 GO:0044262 cellular carbohydrate metabolic process
2.63 1.05e-08 GO:0033036 macromolecule localization
3.30 1.06e-08 GO:0016192 vesicle-mediated transport
21.45 1.31e-08 GO:0006900 membrane budding
6.66 2.54e-08 GO:0006486 protein glycosylation
6.66 2.54e-08 GO:0043413 macromolecule glycosylation
6.62 2.85e-08 GO:0070085 glycosylation
1.47 6.50e-08 GO:0008152 metabolic process
5.87 9.15e-08 GO:0009101 glycoprotein biosynthetic process
17.87 1.11e-07 GO:0006903 vesicle targeting
1.88 3.21e-07 GO:0019538 protein metabolic process
1.49 8.53e-07 GO:0044238 primary metabolic process
1.65 9.77e-07 GO:0044260 cellular macromolecule metabolic process
3.23 2.17e-06 GO:0005975 carbohydrate metabolic process
4.17 2.23e-06 GO:0018193 peptidyl-amino acid modification
9.90 2.78e-06 GO:0016050 vesicle organization
5.34 3.72e-06 GO:0006457 protein folding
4.79 3.83e-06 GO:0009100 glycoprotein metabolic process
12.77 4.46e-06 GO:0051650 establishment of vesicle localization
1.81 5.52e-06 GO:0051234 establishment of localization
1.81 5.76e-06 GO:0006810 transport
1.72 7.89e-06 GO:0051179 localization
22.08 1.41e-05 GO:0070972 protein localization in endoplasmic reticulum
1.53 3.59e-05 GO:0043170 macromolecule metabolic process
8.94 4.00e-05 GO:0045454 cell redox homeostasis
10.12 4.92e-05 GO:0051648 vesicle localization
1.82 2.57e-04 GO:0044249 cellular biosynthetic process
29.79 3.01e-04 GO:0048194 Golgi vesicle budding
29.79 3.01e-04 GO:0048200 Golgi transport vesicle coating
29.79 3.01e-04 GO:0048205 COPI coating of Golgi vesicle
29.79 3.01e-04 GO:0048207 vesicle targeting, rough ER to cis-Golgi
29.79 3.01e-04 GO:0048208 COPII vesicle coating
29.79 3.01e-04 GO:0090114 COPII-coated vesicle budding
1.79 3.22e-04 GO:0009058 biosynthetic process
1.95 3.59e-04 GO:0006464 protein modification process
7.19 4.00e-04 GO:0051656 establishment of organelle localization
1.99 5.49e-04 GO:0009059 macromolecule biosynthetic process
1.98 8.58e-04 GO:0034645 cellular macromolecule biosynthetic process
1.89 9.60e-04 GO:0043412 macromolecule modification
24.37 1.07e-03 GO:0006613 cotranslational protein targeting to membrane
5.70 1.54e-03 GO:0051640 organelle localization
15.32 2.00e-03 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER
3.01 3.37e-03 GO:0016044 cellular membrane organization
3.00 3.65e-03 GO:0061024 membrane organization
9.63 7.86e-03 GO:0006888 ER to Golgi vesicle-mediated transport
26.81 9.08e-03 GO:0045047 protein targeting to ER
26.81 9.08e-03 GO:0072599 establishment of protein localization in endoplasmic reticulum
10.73 1.90e-02 GO:0006984 ER-nucleus signaling pathway
14.11 2.38e-02 GO:0030968 endoplasmic reticulum unfolded protein response
14.11 2.38e-02 GO:0034620 cellular response to unfolded protein
6.70 2.78e-02 GO:0006986 response to unfolded protein
9.75 3.37e-02 GO:0034976 response to endoplasmic reticulum stress
4.44 4.64e-02 GO:0060627 regulation of vesicle-mediated transport

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.95 3.38e-28 GO:0044444 cytoplasmic part
1.64 6.28e-25 GO:0005737 cytoplasm
3.95 4.03e-23 GO:0005783 endoplasmic reticulum
4.36 2.39e-19 GO:0044432 endoplasmic reticulum part
1.81 3.90e-18 GO:0044422 organelle part
1.36 4.97e-18 GO:0044424 intracellular part
1.82 6.13e-18 GO:0044446 intracellular organelle part
2.62 3.02e-17 GO:0031090 organelle membrane
1.32 8.54e-16 GO:0005622 intracellular
2.80 9.14e-15 GO:0012505 endomembrane system
1.39 4.30e-13 GO:0043229 intracellular organelle
1.45 4.53e-13 GO:0043231 intracellular membrane-bounded organelle
1.44 5.27e-13 GO:0043227 membrane-bounded organelle
1.39 5.60e-13 GO:0043226 organelle
3.72 5.41e-12 GO:0042175 nuclear membrane-endoplasmic reticulum network
3.72 1.05e-11 GO:0005789 endoplasmic reticulum membrane
2.84 7.62e-09 GO:0005794 Golgi apparatus
8.67 9.69e-09 GO:0005788 endoplasmic reticulum lumen
3.43 1.97e-06 GO:0000139 Golgi membrane
10.12 9.97e-06 GO:0005793 ER-Golgi intermediate compartment
2.75 1.54e-05 GO:0016023 cytoplasmic membrane-bounded vesicle
2.66 2.23e-05 GO:0031410 cytoplasmic vesicle
2.70 2.43e-05 GO:0031988 membrane-bounded vesicle
22.98 2.50e-05 GO:0030663 COPI coated vesicle membrane
2.91 4.28e-05 GO:0044431 Golgi apparatus part
2.57 4.95e-05 GO:0031982 vesicle
8.13 8.70e-05 GO:0030117 membrane coat
8.13 8.70e-05 GO:0048475 coated membrane
18.92 9.81e-05 GO:0030137 COPI-coated vesicle
11.00 1.17e-04 GO:0030120 vesicle coat
1.81 3.15e-04 GO:0005829 cytosol
1.09 1.28e-03 GO:0044464 cell part
1.09 1.30e-03 GO:0005623 cell
17.87 1.32e-03 GO:0030867 rough endoplasmic reticulum membrane
7.80 1.79e-03 GO:0030176 integral to endoplasmic reticulum membrane
26.81 1.84e-03 GO:0030127 COPII vesicle coat
16.76 1.89e-03 GO:0012507 ER to Golgi transport vesicle membrane
1.71 2.06e-03 GO:0070013 intracellular organelle lumen
5.13 2.38e-03 GO:0030662 coated vesicle membrane
1.67 3.94e-03 GO:0043233 organelle lumen
2.63 3.95e-03 GO:0030529 ribonucleoprotein complex
1.51 3.96e-03 GO:0032991 macromolecular complex
14.11 4.81e-03 GO:0030134 ER to Golgi transport vesicle
10.05 5.67e-03 GO:0030660 Golgi-associated vesicle membrane
1.64 6.64e-03 GO:0031974 membrane-enclosed lumen
3.33 6.80e-03 GO:0030659 cytoplasmic vesicle membrane
5.42 9.84e-03 GO:0042470 melanosome
5.42 9.84e-03 GO:0048770 pigment granule
3.22 1.03e-02 GO:0012506 vesicle membrane
17.87 1.23e-02 GO:0030126 COPI vesicle coat
5.96 1.34e-02 GO:0031227 intrinsic to endoplasmic reticulum membrane
6.95 1.44e-02 GO:0005798 Golgi-associated vesicle
32.17 1.47e-02 GO:0005797 Golgi medial cisterna
8.47 1.57e-02 GO:0005791 rough endoplasmic reticulum
3.54 2.04e-02 GO:0030135 coated vesicle

Gene overrepresentation in function category:

enrichment   p-value GO term description
5.87 3.31e-05 GO:0016853 isomerase activity
1.36 5.10e-05 GO:0005515 protein binding
13.41 1.72e-04 GO:0015035 protein disulfide oxidoreductase activity
12.11 3.64e-04 GO:0015036 disulfide oxidoreductase activity
6.31 1.11e-03 GO:0008565 protein transporter activity
8.41 1.18e-03 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors
2.41 2.41e-03 GO:0016491 oxidoreductase activity
23.83 3.85e-03 GO:0003756 protein disulfide isomerase activity
23.83 3.85e-03 GO:0016862 intramolecular oxidoreductase activity, interconverting keto- and enol-groups
23.83 3.85e-03 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds
1.35 1.24e-02 GO:0003824 catalytic activity