Motif ID: ZFP161.p2

Z-value: 1.990


Transcription factors associated with ZFP161.p2:

Gene SymbolEntrez IDGene Name
ZFP161 7541 zinc finger protein 161 homolog (mouse)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ZFP161chr18_-_5295606,
chr18_-_5297051
0.063.4e-01Click!


Activity profile for motif ZFP161.p2.

activity profile for motif ZFP161.p2


Sorted Z-values histogram for motif ZFP161.p2

Sorted Z-values for motif ZFP161.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ZFP161.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr14_+_100438095 35.954 EVL
Enah/Vasp-like
chr16_+_2039945 30.075 NM_004209
SYNGR3
synaptogyrin 3
chr16_+_58497993 28.676 NM_001130487
NDRG4
NDRG family member 4
chr11_-_33890931 27.614 LMO2
LIM domain only 2 (rhombotin-like 1)
chr16_+_58497628 27.611 NDRG4
NDRG family member 4
chr16_+_56225301 26.788 GNAO1
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
chr17_+_44668034 26.134 NM_006178
NSF
N-ethylmaleimide-sensitive factor
chr8_+_26435339 25.922 NM_001386
DPYSL2
dihydropyrimidinase-like 2
chr16_+_56623266 25.097 NM_005954
MT3
metallothionein 3
chr16_+_58497548 23.678 NM_020465
NDRG4
NDRG family member 4
chr1_-_9884024 23.225 CLSTN1
calsyntenin 1
chr1_-_9884549 23.200 NM_001009566
NM_014944
CLSTN1

calsyntenin 1

chr17_+_43971868 22.633 MAPT
microtubule-associated protein tau
chr17_+_43971998 22.003 MAPT
microtubule-associated protein tau
chr22_-_39548448 21.910 NM_175709
CBX7
chromobox homolog 7
chr10_+_105037441 21.760 INA
internexin neuronal intermediate filament protein, alpha
chr20_+_17207669 21.167 PCSK2
proprotein convertase subtilisin/kexin type 2
chr19_-_19006868 20.962 NM_021267
NM_198207
NM_001492
CERS1

GDF1
ceramide synthase 1

growth differentiation factor 1
chr9_-_136024522 20.559 NM_001042368
RALGDS
ral guanine nucleotide dissociation stimulator
chrX_+_153665468 20.363 GDI1
GDP dissociation inhibitor 1
chr5_-_88179278 20.325 NM_001193350
NM_002397
MEF2C

myocyte enhancer factor 2C

chr11_-_33891258 20.019 LMO2
LIM domain only 2 (rhombotin-like 1)
chr11_-_6440631 19.723 NM_145689
APBB1
amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
chr16_+_58498182 19.651 NDRG4
NDRG family member 4
chr8_+_26435466 19.350 DPYSL2
dihydropyrimidinase-like 2
chr16_+_58498216 19.259 NDRG4
NDRG family member 4
chr10_+_124220990 19.004 NM_002775
HTRA1
HtrA serine peptidase 1
chr5_-_11904127 18.811 CTNND2
catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)
chr15_+_75287829 18.264 NM_001178111
NM_001178112
NM_138967
SCAMP5


secretory carrier membrane protein 5


chr17_+_43972014 18.085 MAPT
microtubule-associated protein tau
chr20_+_44657858 17.888 SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5
chr4_-_102268333 17.809 PPP3CA
protein phosphatase 3, catalytic subunit, alpha isozyme
chr17_+_43971655 17.729 NM_001123066
NM_001123067
NM_001203251
NM_001203252
NM_005910
NM_016834
NM_016835
NM_016841
MAPT







microtubule-associated protein tau







chr11_-_134281725 17.725 NM_018644
NM_054025
B3GAT1

beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)

chr1_+_228675042 17.329 NM_001010858
RNF187
ring finger protein 187
chr11_-_6440288 17.302 NM_001164
APBB1
amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
chr4_-_1242742 17.281 CTBP1
C-terminal binding protein 1
chrX_+_38420690 16.982 NM_004615
TSPAN7
tetraspanin 7
chr3_+_142838596 16.924 NM_004267
CHST2
carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
chr10_+_111985628 16.766 NM_005962
MXI1
MAX interactor 1
chr5_-_11903964 16.686 NM_001332
CTNND2
catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)
chr6_-_6007632 16.000 NM_016588
NRN1
neuritin 1
chr17_+_40118696 15.884 NM_033133
CNP
2',3'-cyclic nucleotide 3' phosphodiesterase
chr4_+_158141735 15.598 NM_000826
NM_001083619
NM_001083620
GRIA2


glutamate receptor, ionotropic, AMPA 2


chr1_-_20812727 15.549 NM_018584
CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr7_+_45614081 15.364 NM_021116
ADCY1
adenylate cyclase 1 (brain)
chr13_-_36705432 15.350 DCLK1
doublecortin-like kinase 1
chr5_-_88178964 15.272 MEF2C
myocyte enhancer factor 2C
chr20_+_17207680 15.239 PCSK2
proprotein convertase subtilisin/kexin type 2
chr20_+_44657812 14.570 NM_020708
SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5
chr19_+_47104559 14.456 CALM3
calmodulin 3 (phosphorylase kinase, delta)
chr3_-_127541975 14.365 NM_001003794
MGLL
monoglyceride lipase
chr7_+_153584383 14.302 NM_001039350
DPP6
dipeptidyl-peptidase 6
chr16_+_30194730 14.263 NM_001193333
NM_007074
CORO1A

coronin, actin binding protein, 1A

chrX_+_153665258 14.223 NM_001493
GDI1
GDP dissociation inhibitor 1
chr9_+_34958320 14.198 KIAA1045
KIAA1045
chr16_+_30194925 14.176 CORO1A
coronin, actin binding protein, 1A
chr12_-_124457099 14.051 NM_025140
CCDC92
coiled-coil domain containing 92
chr11_+_121322848 14.014 NM_003105
SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr12_-_121734543 14.007 NM_172226
CAMKK2
calcium/calmodulin-dependent protein kinase kinase 2, beta
chr22_-_39152008 13.912 NM_001199579
NM_015374
SUN2

Sad1 and UNC84 domain containing 2

chr7_-_44365019 13.781 NM_001220
NM_172078
NM_172079
NM_172080
NM_172081
NM_172082
NM_172083
NM_172084
CAMK2B







calcium/calmodulin-dependent protein kinase II beta







chr16_+_56225250 13.762 NM_020988
NM_138736
GNAO1

guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O

chr22_-_39268214 13.706 CBX6
chromobox homolog 6
chr9_+_137967401 13.585 OLFM1
olfactomedin 1
chr13_+_113622758 13.428 MCF2L
MCF.2 cell line derived transforming sequence-like
chr10_-_73611005 13.368 PSAP
prosaposin
chr4_-_176923480 13.189 GPM6A
glycoprotein M6A
chr15_+_91643429 13.148 NM_014848
SV2B
synaptic vesicle glycoprotein 2B
chr11_-_125366048 13.069 NM_005103
NM_022549
FEZ1

fasciculation and elongation protein zeta 1 (zygin I)

chr11_+_46368881 13.030 NM_001199266
NM_001199267
NM_001199268
NM_003646
DGKZ



diacylglycerol kinase, zeta



chr11_-_1593149 12.983 NM_004420
DUSP8
dual specificity phosphatase 8
chr9_+_130374466 12.821 NM_001032221
NM_003165
STXBP1

syntaxin binding protein 1

chr20_+_57464156 12.788 GNAS
GNAS complex locus
chr8_-_125740650 12.758 NM_014751
MTSS1
metastasis suppressor 1
chr10_+_11060105 12.649 CELF2
CUGBP, Elav-like family member 2
chr20_+_17207596 12.610 NM_001201529
NM_002594
PCSK2

proprotein convertase subtilisin/kexin type 2

chr12_+_13197284 12.560 NM_020853
KIAA1467
KIAA1467
chr8_+_1922030 12.540 NM_014867
KBTBD11
kelch repeat and BTB (POZ) domain containing 11
chr12_-_121734474 12.290 CAMKK2
calcium/calmodulin-dependent protein kinase kinase 2, beta
chr22_-_39268169 12.287 CBX6
chromobox homolog 6
chr11_-_33891361 12.248 NM_001142316
LMO2
LIM domain only 2 (rhombotin-like 1)
chr22_-_45636760 12.239 KIAA0930
KIAA0930
chr3_-_133614421 12.237 NM_016577
RAB6B
RAB6B, member RAS oncogene family
chr9_-_139922705 12.188 NM_001606
ABCA2
ATP-binding cassette, sub-family A (ABC1), member 2
chr19_+_47104490 12.088 NM_005184
CALM3
calmodulin 3 (phosphorylase kinase, delta)
chr18_-_74844762 12.060 NM_001025100
NM_001025101
MBP

myelin basic protein

chr8_-_144241918 11.986 NM_001130478
LY6H
lymphocyte antigen 6 complex, locus H
chr3_+_50712671 11.818 NM_004947
DOCK3
dedicator of cytokinesis 3
chr22_-_39151979 11.775 SUN2
Sad1 and UNC84 domain containing 2
chr9_+_137967088 11.697 NM_014279
NM_006334
OLFM1

olfactomedin 1

chr9_-_132805456 11.690 NM_015033
FNBP1
formin binding protein 1
chr1_+_204797774 11.681 NM_001005388
NM_001005389
NM_001160332
NM_001160333
NM_015090
NFASC




neurofascin




chr17_+_79651052 11.611


chr4_-_5894695 11.516 NM_001014809
CRMP1
collapsin response mediator protein 1
chr19_-_42498320 11.503 NM_152296
ATP1A3
ATPase, Na+/K+ transporting, alpha 3 polypeptide
chr22_-_39268230 11.460 NM_014292
CBX6
chromobox homolog 6
chr10_-_104179468 11.451 PSD
pleckstrin and Sec7 domain containing
chr6_-_13486382 11.432 NM_001242628
GFOD1
glucose-fructose oxidoreductase domain containing 1
chr14_+_105780903 11.273 PACS2
phosphofurin acidic cluster sorting protein 2
chr4_-_1242882 11.269 NM_001012614
NM_001328
CTBP1

C-terminal binding protein 1

chr22_-_20104695 11.179 TRMT2A
TRM2 tRNA methyltransferase 2 homolog A (S. cerevisiae)
chr9_+_137967366 11.160 OLFM1
olfactomedin 1
chr19_-_5340700 11.113 NM_002850
NM_130853
NM_130854
NM_130855
PTPRS



protein tyrosine phosphatase, receptor type, S



chr14_-_93651242 11.076 NM_022151
MOAP1
modulator of apoptosis 1
chr17_+_40118792 11.028 CNP
2',3'-cyclic nucleotide 3' phosphodiesterase
chr10_+_11059854 10.872 NM_006561
CELF2
CUGBP, Elav-like family member 2
chr11_-_64410785 10.847 NM_138734
NRXN2
neurexin 2
chr14_-_93651182 10.813 MOAP1
modulator of apoptosis 1
chr19_-_42498221 10.643 ATP1A3
ATPase, Na+/K+ transporting, alpha 3 polypeptide
chrX_-_107018889 10.616 TSC22D3
TSC22 domain family, member 3
chr9_+_131314669 10.455 NM_001130438
NM_001195532
NM_003127
SPTAN1


spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)


chr19_+_35634153 10.360 NM_022006
FXYD7
FXYD domain containing ion transport regulator 7
chr4_-_102268626 10.324 NM_000944
NM_001130691
NM_001130692
PPP3CA


protein phosphatase 3, catalytic subunit, alpha isozyme


chr8_-_144241678 10.298 LY6H
lymphocyte antigen 6 complex, locus H
chr10_+_11060069 10.154 CELF2
CUGBP, Elav-like family member 2
chrX_-_107019001 10.153 NM_198057
TSC22D3
TSC22 domain family, member 3
chr20_+_11871364 10.152 NM_181443
BTBD3
BTB (POZ) domain containing 3
chr22_+_32340592 10.146 YWHAH
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide
chr17_+_73043319 10.125 KCTD2
potassium channel tetramerisation domain containing 2
chr13_+_113623496 10.079 NM_001112732
MCF2L
MCF.2 cell line derived transforming sequence-like
chr9_-_139922595 10.043 ABCA2
ATP-binding cassette, sub-family A (ABC1), member 2
chr4_+_6784453 9.876 NM_001100590
NM_014743
KIAA0232

KIAA0232

chr20_+_57466721 9.803 GNAS
GNAS complex locus
chrX_-_153362979 9.777 MECP2
LOC728653
methyl CpG binding protein 2 (Rett syndrome)
uncharacterized LOC728653
chrX_-_137793394 9.769 FGF13
fibroblast growth factor 13
chr9_+_103235634 9.752 TMEFF1
transmembrane protein with EGF-like and two follistatin-like domains 1
chr1_+_84543629 9.566 NM_002731
NM_207578
PRKACB

protein kinase, cAMP-dependent, catalytic, beta

chr2_+_207308280 9.555 NM_003812
ADAM23
ADAM metallopeptidase domain 23
chr4_-_109684053 9.546 NM_001146590
NM_001146627
NM_031279
AGXT2L1


alanine-glyoxylate aminotransferase 2-like 1


chr1_-_32229635 9.519 NM_001703
BAI2
brain-specific angiogenesis inhibitor 2
chr15_-_38856830 9.486 NM_001128602
NM_005739
RASGRP1

RAS guanyl releasing protein 1 (calcium and DAG-regulated)

chr19_-_1885431 9.475 FAM108A1
family with sequence similarity 108, member A1
chr17_-_78450247 9.380 NM_002522
NPTX1
neuronal pentraxin I
chr12_+_121078421 9.295 NM_001033677
CABP1
calcium binding protein 1
chr17_-_57184034 9.176 TRIM37
tripartite motif containing 37
chr17_-_57184174 9.171 NM_001005207
NM_015294
TRIM37

tripartite motif containing 37

chr19_-_1885375 9.053 FAM108A1
family with sequence similarity 108, member A1
chr11_+_63448868 9.023 NM_006054
NM_201428
NM_201429
NM_201430
RTN3



reticulon 3



chr10_-_73611041 9.020 PSAP
prosaposin
chr4_+_6784487 8.916 KIAA0232
KIAA0232
chr19_-_1885485 8.851 NM_001130111
NM_031213
FAM108A1

family with sequence similarity 108, member A1

chr19_-_1885462 8.790 FAM108A1
family with sequence similarity 108, member A1
chr4_+_6784462 8.700 KIAA0232
KIAA0232
chr3_-_127541160 8.583 NM_007283
MGLL
monoglyceride lipase
chr12_-_99038401 8.576 NM_153687
NM_201612
NM_201613
IKBIP


IKBKB interacting protein


chr20_+_57466509 8.525 GNAS
GNAS complex locus
chr13_-_77460432 8.512 NM_138444
KCTD12
potassium channel tetramerisation domain containing 12
chr19_+_35521591 8.464 NM_001037
NM_199037
SCN1B

sodium channel, voltage-gated, type I, beta

chr2_+_79740059 8.460 NM_001164883
NM_004389
CTNNA2

catenin (cadherin-associated protein), alpha 2

chr16_+_6533758 8.418 RBFOX1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr5_+_76506705 8.391 NM_001029851
NM_001029852
NM_001029853
NM_001029854
NM_003719
PDE8B




phosphodiesterase 8B




chr1_-_200992824 8.383 NM_001252100
NM_001252102
NM_001252103
NM_017596
KIF21B



kinesin family member 21B



chr7_-_55640070 8.350 VOPP1
vesicular, overexpressed in cancer, prosurvival protein 1
chr14_+_105781180 8.321 PACS2
phosphofurin acidic cluster sorting protein 2
chr4_+_166128823 8.266 KLHL2
kelch-like 2, Mayven (Drosophila)
chr17_+_73043154 8.260 NM_015353
KCTD2
potassium channel tetramerisation domain containing 2
chr11_-_695069 8.235 DEAF1
deformed epidermal autoregulatory factor 1 (Drosophila)
chr22_-_20104745 8.208 NM_022727
NM_182984
TRMT2A

TRM2 tRNA methyltransferase 2 homolog A (S. cerevisiae)

chr9_+_34958171 8.194 NM_015297
KIAA1045
KIAA1045
chr2_+_11052062 8.188 NM_002236
KCNF1
potassium voltage-gated channel, subfamily F, member 1
chr1_-_241520384 8.175 RGS7
regulator of G-protein signaling 7
chr12_+_112451229 8.172


chr16_-_1832576 8.113 NM_080861
SPSB3
splA/ryanodine receptor domain and SOCS box containing 3
chr4_+_71859391 8.034 DCK
deoxycytidine kinase
chr10_+_104179570 8.034 NM_024326
FBXL15
F-box and leucine-rich repeat protein 15
chr13_-_77901176 8.032 NM_015057
MYCBP2
MYC binding protein 2
chr18_-_74844710 7.985 MBP
myelin basic protein
chr16_-_1832304 7.982 SPSB3
splA/ryanodine receptor domain and SOCS box containing 3
chr14_-_60097314 7.949 RTN1
reticulon 1
chr13_-_36705513 7.935 NM_004734
DCLK1
doublecortin-like kinase 1
chr12_+_108956293 7.895 NM_014301
NM_213595
ISCU

iron-sulfur cluster scaffold homolog (E. coli)

chr7_-_150974179 7.881 NM_003078
SMARCD3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
chr20_+_20348744 7.874 NM_002196
INSM1
insulinoma-associated 1
chr9_-_135996287 7.827 NM_006266
RALGDS
ral guanine nucleotide dissociation stimulator
chr1_+_226736500 7.801 NM_001003665
C1orf95
chromosome 1 open reading frame 95
chr3_+_23987514 7.768 NM_001145425
NR1D2
nuclear receptor subfamily 1, group D, member 2
chr16_-_4852571 7.740 NM_024589
ROGDI
rogdi homolog (Drosophila)
chr4_-_15656944 7.719 FBXL5
F-box and leucine-rich repeat protein 5
chr4_+_41362750 7.715 NM_001112717
NM_001112718
NM_014988
LIMCH1


LIM and calponin homology domains 1


chr7_-_55640104 7.698 VOPP1
vesicular, overexpressed in cancer, prosurvival protein 1
chr10_-_88854686 7.668 NM_005271
GLUD1
glutamate dehydrogenase 1
chr17_+_2240795 7.660 NM_014853
NM_001098509
SGSM2

small G protein signaling modulator 2

chr4_-_83351294 7.603 NM_001207000
NM_031372
HNRPDL

heterogeneous nuclear ribonucleoprotein D-like

chrX_+_51927918 7.592 NM_001098800
NM_001242362
NM_030801
NM_177535
NM_177537
MAGED4
MAGED4B



melanoma antigen family D, 4
melanoma antigen family D, 4B



chr14_-_60097223 7.578 RTN1
reticulon 1
chr11_-_64511550 7.563 NM_001098671
RASGRP2
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
chr2_+_234263141 7.529 NM_152879
DGKD
diacylglycerol kinase, delta 130kDa
chr3_-_56502364 7.477 NM_015576
ERC2
ELKS/RAB6-interacting/CAST family member 2
chr1_-_29508263 7.461 SRSF4
serine/arginine-rich splicing factor 4
chr12_-_112450914 7.436 NM_001193453
NM_001193531
NM_138341
LOC728543
TMEM116


uncharacterized LOC728543
transmembrane protein 116


chr7_-_55640131 7.392 VOPP1
vesicular, overexpressed in cancer, prosurvival protein 1
chr9_+_77703412 7.368 OSTF1
osteoclast stimulating factor 1
chr8_-_144241725 7.345 NM_001135655
LY6H
lymphocyte antigen 6 complex, locus H
chr19_+_47104389 7.337 CALM3
calmodulin 3 (phosphorylase kinase, delta)
chr1_-_241520467 7.280 NM_002924
RGS7
regulator of G-protein signaling 7
chr1_+_6845381 7.258 NM_001195563
NM_001242701
NM_015215
CAMTA1


calmodulin binding transcription activator 1


chr9_-_92112887 7.220 SEMA4D
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
chr3_+_40351193 7.198 EIF1B
eukaryotic translation initiation factor 1B
chr16_-_5083933 7.183 NM_016256
NAGPA
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.27 2.35e-25 GO:0050794 regulation of cellular process
1.25 4.23e-24 GO:0050789 regulation of biological process
1.75 6.18e-24 GO:0007399 nervous system development
1.24 5.01e-23 GO:0065007 biological regulation
1.39 3.14e-20 GO:0023052 signaling
1.14 6.86e-20 GO:0009987 cellular process
1.62 3.43e-18 GO:0023051 regulation of signaling
1.79 1.72e-17 GO:0006793 phosphorus metabolic process
1.79 1.72e-17 GO:0006796 phosphate metabolic process
1.54 6.31e-16 GO:0006464 protein modification process
1.78 5.69e-15 GO:0022008 neurogenesis
1.36 9.35e-15 GO:0007165 signal transduction
1.80 9.87e-15 GO:0048699 generation of neurons
1.50 3.42e-14 GO:0043412 macromolecule modification
1.60 1.33e-13 GO:0035556 intracellular signal transduction
1.57 3.51e-13 GO:0009966 regulation of signal transduction
1.76 6.53e-13 GO:0016310 phosphorylation
1.22 3.04e-12 GO:0044237 cellular metabolic process
1.45 3.36e-12 GO:0030154 cell differentiation
1.32 6.24e-12 GO:0051179 localization
1.30 6.78e-12 GO:0032502 developmental process
1.44 8.72e-12 GO:0048869 cellular developmental process
1.78 9.09e-12 GO:0006468 protein phosphorylation
1.32 2.51e-11 GO:0007275 multicellular organismal development
1.35 8.37e-11 GO:0048731 system development
1.32 1.80e-10 GO:0048856 anatomical structure development
1.80 2.18e-10 GO:0007167 enzyme linked receptor protein signaling pathway
1.75 4.99e-10 GO:0030182 neuron differentiation
1.29 5.36e-10 GO:0031323 regulation of cellular metabolic process
1.29 7.44e-10 GO:0080090 regulation of primary metabolic process
1.27 8.06e-10 GO:0019222 regulation of metabolic process
1.37 1.05e-09 GO:0048519 negative regulation of biological process
1.63 1.30e-09 GO:0048468 cell development
1.82 1.43e-09 GO:0048666 neuron development
1.26 1.45e-09 GO:0051716 cellular response to stimulus
1.42 1.61e-09 GO:0048583 regulation of response to stimulus
1.57 3.60e-09 GO:0010646 regulation of cell communication
1.38 4.93e-09 GO:0048523 negative regulation of cellular process
1.62 7.29e-09 GO:0050793 regulation of developmental process
1.84 1.07e-08 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.85 1.21e-08 GO:0019226 transmission of nerve impulse
1.85 1.21e-08 GO:0035637 multicellular organismal signaling
1.29 1.39e-08 GO:0060255 regulation of macromolecule metabolic process
1.41 2.34e-08 GO:0007166 cell surface receptor linked signaling pathway
1.49 4.34e-08 GO:0051239 regulation of multicellular organismal process
1.82 5.97e-08 GO:0031175 neuron projection development
1.86 1.43e-07 GO:0007268 synaptic transmission
1.86 1.43e-07 GO:0048667 cell morphogenesis involved in neuron differentiation
1.68 1.55e-07 GO:0045595 regulation of cell differentiation
1.29 1.98e-07 GO:0051234 establishment of localization
1.32 2.67e-07 GO:0048522 positive regulation of cellular process
1.84 2.74e-07 GO:0023057 negative regulation of signaling
1.69 2.86e-07 GO:0030030 cell projection organization
1.84 3.22e-07 GO:0010648 negative regulation of cell communication
1.31 3.37e-07 GO:0010468 regulation of gene expression
1.77 4.35e-07 GO:0007417 central nervous system development
1.83 4.43e-07 GO:0048812 neuron projection morphogenesis
1.28 7.06e-07 GO:0006810 transport
1.84 8.11e-07 GO:0007409 axonogenesis
1.76 9.23e-07 GO:0048858 cell projection morphogenesis
1.31 1.03e-06 GO:0044267 cellular protein metabolic process
1.15 1.25e-06 GO:0008152 metabolic process
1.76 1.25e-06 GO:0000904 cell morphogenesis involved in differentiation
1.61 1.30e-06 GO:2000026 regulation of multicellular organismal development
1.29 1.49e-06 GO:0048518 positive regulation of biological process
1.84 1.50e-06 GO:0009968 negative regulation of signal transduction
1.75 1.64e-06 GO:0032990 cell part morphogenesis
1.31 1.77e-06 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.21 1.98e-06 GO:0044260 cellular macromolecule metabolic process
1.84 2.76e-06 GO:0007264 small GTPase mediated signal transduction
2.13 2.89e-06 GO:0048011 nerve growth factor receptor signaling pathway
1.25 3.21e-06 GO:0016043 cellular component organization
1.29 3.51e-06 GO:0009889 regulation of biosynthetic process
1.63 3.74e-06 GO:0009719 response to endogenous stimulus
1.51 4.20e-06 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.30 4.69e-06 GO:0010556 regulation of macromolecule biosynthetic process
1.16 5.90e-06 GO:0044238 primary metabolic process
1.28 6.20e-06 GO:0031326 regulation of cellular biosynthetic process
1.43 8.09e-06 GO:0051641 cellular localization
1.28 8.85e-06 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.88 1.20e-05 GO:0045597 positive regulation of cell differentiation
1.49 1.34e-05 GO:0032879 regulation of localization
1.70 1.41e-05 GO:0048585 negative regulation of response to stimulus
1.47 2.01e-05 GO:0032268 regulation of cellular protein metabolic process
1.58 2.03e-05 GO:0019220 regulation of phosphate metabolic process
1.58 2.03e-05 GO:0051174 regulation of phosphorus metabolic process
1.63 2.83e-05 GO:0000902 cell morphogenesis
1.60 3.75e-05 GO:0032989 cellular component morphogenesis
1.45 3.81e-05 GO:0051246 regulation of protein metabolic process
1.30 5.32e-05 GO:0065008 regulation of biological quality
1.58 5.48e-05 GO:0042325 regulation of phosphorylation
1.61 5.75e-05 GO:0010629 negative regulation of gene expression
1.92 5.87e-05 GO:0051960 regulation of nervous system development
1.26 6.69e-05 GO:0051171 regulation of nitrogen compound metabolic process
1.60 7.81e-05 GO:0009725 response to hormone stimulus
1.29 9.08e-05 GO:0006355 regulation of transcription, DNA-dependent
1.22 1.01e-04 GO:0071840 cellular component organization or biogenesis
1.51 1.02e-04 GO:0051128 regulation of cellular component organization
1.46 1.07e-04 GO:0009892 negative regulation of metabolic process
1.58 1.08e-04 GO:0001932 regulation of protein phosphorylation
1.29 1.09e-04 GO:0042221 response to chemical stimulus
1.26 1.10e-04 GO:0071842 cellular component organization at cellular level
1.95 1.33e-04 GO:0050767 regulation of neurogenesis
1.62 1.57e-04 GO:0051253 negative regulation of RNA metabolic process
1.99 1.60e-04 GO:0071375 cellular response to peptide hormone stimulus
1.63 1.68e-04 GO:0045892 negative regulation of transcription, DNA-dependent
1.94 1.92e-04 GO:0000165 MAPKKK cascade
1.28 2.20e-04 GO:0051252 regulation of RNA metabolic process
1.68 2.38e-04 GO:0051094 positive regulation of developmental process
1.35 2.65e-04 GO:0009653 anatomical structure morphogenesis
1.49 3.02e-04 GO:0031399 regulation of protein modification process
1.47 3.36e-04 GO:0040011 locomotion
1.37 3.62e-04 GO:0033036 macromolecule localization
1.45 5.49e-04 GO:0010605 negative regulation of macromolecule metabolic process
1.40 6.89e-04 GO:0051649 establishment of localization in cell
1.46 7.06e-04 GO:0006351 transcription, DNA-dependent
1.53 7.32e-04 GO:0010558 negative regulation of macromolecule biosynthetic process
1.55 8.31e-04 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.54 8.39e-04 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.66 8.39e-04 GO:0032583 regulation of gene-specific transcription
2.62 8.93e-04 GO:0030178 negative regulation of Wnt receptor signaling pathway
2.35 9.19e-04 GO:0031098 stress-activated protein kinase signaling cascade
2.04 1.03e-03 GO:0032869 cellular response to insulin stimulus
1.74 1.07e-03 GO:0043434 response to peptide hormone stimulus
1.75 1.08e-03 GO:0007411 axon guidance
1.34 1.19e-03 GO:0065009 regulation of molecular function
1.51 1.20e-03 GO:0009890 negative regulation of biosynthetic process
1.38 1.47e-03 GO:0010604 positive regulation of macromolecule metabolic process
1.79 1.53e-03 GO:0009205 purine ribonucleoside triphosphate metabolic process
2.18 1.59e-03 GO:0008286 insulin receptor signaling pathway
1.53 1.71e-03 GO:0051172 negative regulation of nitrogen compound metabolic process
2.60 1.72e-03 GO:0034142 toll-like receptor 4 signaling pathway
1.70 1.74e-03 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
1.65 1.77e-03 GO:0007243 intracellular protein kinase cascade
1.65 1.77e-03 GO:0023014 signal transduction via phosphorylation event
1.78 1.78e-03 GO:0009199 ribonucleoside triphosphate metabolic process
1.36 2.15e-03 GO:0009893 positive regulation of metabolic process
2.45 2.16e-03 GO:0002221 pattern recognition receptor signaling pathway
2.48 2.25e-03 GO:0002224 toll-like receptor signaling pathway
1.66 2.26e-03 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.75 2.35e-03 GO:0032870 cellular response to hormone stimulus
1.77 2.39e-03 GO:0009144 purine nucleoside triphosphate metabolic process
1.72 2.56e-03 GO:0071495 cellular response to endogenous stimulus
1.49 2.87e-03 GO:0031327 negative regulation of cellular biosynthetic process
1.74 3.09e-03 GO:0060284 regulation of cell development
1.93 3.15e-03 GO:0045664 regulation of neuron differentiation
1.75 3.17e-03 GO:0009141 nucleoside triphosphate metabolic process
1.77 3.25e-03 GO:0051270 regulation of cellular component movement
1.23 3.35e-03 GO:0071841 cellular component organization or biogenesis at cellular level
1.45 3.36e-03 GO:0046907 intracellular transport
1.87 3.61e-03 GO:0032868 response to insulin stimulus
2.70 4.48e-03 GO:0034138 toll-like receptor 3 signaling pathway
2.37 5.04e-03 GO:0002758 innate immune response-activating signal transduction
1.70 5.15e-03 GO:0009259 ribonucleotide metabolic process
1.67 5.20e-03 GO:0007420 brain development
1.61 5.24e-03 GO:0072521 purine-containing compound metabolic process
2.21 5.43e-03 GO:0007265 Ras protein signal transduction
1.49 5.49e-03 GO:0071310 cellular response to organic substance
1.37 5.49e-03 GO:0008104 protein localization
1.70 5.89e-03 GO:0044057 regulation of system process
2.51 6.17e-03 GO:0008063 Toll signaling pathway
3.64 6.80e-03 GO:0021954 central nervous system neuron development
1.41 6.96e-03 GO:0031324 negative regulation of cellular metabolic process
2.92 7.23e-03 GO:0051403 stress-activated MAPK cascade
1.55 8.56e-03 GO:0006753 nucleoside phosphate metabolic process
1.55 8.56e-03 GO:0009117 nucleotide metabolic process
2.32 8.61e-03 GO:0002218 activation of innate immune response
2.56 8.80e-03 GO:0034130 toll-like receptor 1 signaling pathway
2.56 8.80e-03 GO:0034134 toll-like receptor 2 signaling pathway
1.69 9.38e-03 GO:0009150 purine ribonucleotide metabolic process
1.33 1.12e-02 GO:0010033 response to organic substance
1.34 1.19e-02 GO:0031325 positive regulation of cellular metabolic process
2.02 1.20e-02 GO:0001666 response to hypoxia
1.63 1.40e-02 GO:0090066 regulation of anatomical structure size
1.76 1.48e-02 GO:0009166 nucleotide catabolic process
1.63 1.58e-02 GO:0051056 regulation of small GTPase mediated signal transduction
1.61 1.60e-02 GO:0006163 purine nucleotide metabolic process
1.37 1.60e-02 GO:0007154 cell communication
1.28 1.65e-02 GO:0006996 organelle organization
2.02 1.92e-02 GO:0006184 GTP catabolic process
1.71 2.17e-02 GO:0034655 nucleobase, nucleoside, nucleotide and nucleic acid catabolic process
1.71 2.17e-02 GO:0034656 nucleobase, nucleoside and nucleotide catabolic process
1.68 2.22e-02 GO:0007610 behavior
1.77 2.38e-02 GO:0006195 purine nucleotide catabolic process
1.80 2.40e-02 GO:0009261 ribonucleotide catabolic process
1.66 2.70e-02 GO:0051093 negative regulation of developmental process
1.75 2.73e-02 GO:0072523 purine-containing compound catabolic process
1.58 2.79e-02 GO:0016477 cell migration
2.05 2.84e-02 GO:0030111 regulation of Wnt receptor signaling pathway
2.42 2.94e-02 GO:0002755 MyD88-dependent toll-like receptor signaling pathway
2.51 3.21e-02 GO:0002756 MyD88-independent toll-like receptor signaling pathway
1.84 3.21e-02 GO:0044087 regulation of cellular component biogenesis
1.14 3.41e-02 GO:0043170 macromolecule metabolic process
1.88 3.56e-02 GO:0006913 nucleocytoplasmic transport
1.78 3.79e-02 GO:0009154 purine ribonucleotide catabolic process
1.41 4.28e-02 GO:0007267 cell-cell signaling
1.94 4.34e-02 GO:0046039 GTP metabolic process
1.13 4.67e-02 GO:0032501 multicellular organismal process
1.71 4.72e-02 GO:0030334 regulation of cell migration
1.53 4.93e-02 GO:0048870 cell motility
1.53 4.93e-02 GO:0051674 localization of cell
1.86 4.98e-02 GO:0051169 nuclear transport

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.13 4.10e-19 GO:0044424 intracellular part
1.13 1.76e-18 GO:0005622 intracellular
1.18 1.01e-15 GO:0005737 cytoplasm
1.14 8.44e-14 GO:0043226 organelle
1.14 3.23e-13 GO:0043229 intracellular organelle
1.15 2.16e-12 GO:0043227 membrane-bounded organelle
1.15 5.40e-12 GO:0043231 intracellular membrane-bounded organelle
1.19 2.57e-08 GO:0005634 nucleus
1.17 1.79e-07 GO:0044444 cytoplasmic part
1.54 1.42e-06 GO:0031982 vesicle
1.48 1.73e-06 GO:0005794 Golgi apparatus
1.77 1.80e-06 GO:0045202 synapse
1.53 6.16e-06 GO:0031410 cytoplasmic vesicle
1.74 7.90e-06 GO:0043005 neuron projection
1.30 1.36e-05 GO:0005829 cytosol
1.04 1.71e-05 GO:0044464 cell part
1.04 1.79e-05 GO:0005623 cell
1.51 3.55e-05 GO:0016023 cytoplasmic membrane-bounded vesicle
1.50 4.27e-05 GO:0031988 membrane-bounded vesicle
1.56 7.21e-05 GO:0044431 Golgi apparatus part
2.05 7.34e-05 GO:0030424 axon
1.57 5.62e-04 GO:0000139 Golgi membrane
2.51 8.55e-04 GO:0033267 axon part
1.70 1.55e-03 GO:0044456 synapse part
1.44 2.60e-03 GO:0015630 microtubule cytoskeleton
1.13 2.77e-03 GO:0044446 intracellular organelle part
2.20 4.16e-03 GO:0019717 synaptosome
1.13 4.63e-03 GO:0044422 organelle part
1.38 5.99e-03 GO:0005626 insoluble fraction
1.30 6.08e-03 GO:0005654 nucleoplasm
1.66 7.18e-03 GO:0005874 microtubule
2.09 1.80e-02 GO:0019898 extrinsic to membrane
1.35 2.74e-02 GO:0005624 membrane fraction
1.34 2.76e-02 GO:0042995 cell projection

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.23 9.24e-21 GO:0005515 protein binding
1.12 3.22e-19 GO:0005488 binding
1.76 4.05e-12 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.72 8.13e-12 GO:0016301 kinase activity
1.37 1.34e-10 GO:0000166 nucleotide binding
1.78 2.22e-10 GO:0004672 protein kinase activity
1.93 2.60e-10 GO:0004674 protein serine/threonine kinase activity
1.39 3.05e-09 GO:0017076 purine nucleotide binding
1.59 3.65e-09 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.39 5.49e-09 GO:0032553 ribonucleotide binding
1.39 5.49e-09 GO:0032555 purine ribonucleotide binding
1.38 1.38e-08 GO:0035639 purine ribonucleoside triphosphate binding
1.60 1.40e-07 GO:0019899 enzyme binding
1.75 1.49e-06 GO:0019904 protein domain specific binding
1.16 1.55e-05 GO:0003824 catalytic activity
1.34 3.45e-05 GO:0030554 adenyl nucleotide binding
1.44 5.43e-05 GO:0001071 nucleic acid binding transcription factor activity
1.44 5.43e-05 GO:0003700 sequence-specific DNA binding transcription factor activity
1.34 6.63e-05 GO:0032559 adenyl ribonucleotide binding
1.42 8.81e-05 GO:0030528 transcription regulator activity
1.33 1.10e-04 GO:0005524 ATP binding
1.81 1.15e-04 GO:0008134 transcription factor binding
1.31 1.41e-04 GO:0016740 transferase activity
1.60 3.91e-04 GO:0060589 nucleoside-triphosphatase regulator activity
1.69 7.91e-04 GO:0042578 phosphoric ester hydrolase activity
1.58 1.13e-03 GO:0030695 GTPase regulator activity
1.85 2.38e-03 GO:0003924 GTPase activity
1.98 2.49e-03 GO:0004721 phosphoprotein phosphatase activity
1.76 4.43e-03 GO:0016791 phosphatase activity
2.18 9.70e-03 GO:0005057 receptor signaling protein activity
1.58 1.05e-02 GO:0019001 guanyl nucleotide binding
1.58 1.05e-02 GO:0032561 guanyl ribonucleotide binding
1.96 1.06e-02 GO:0022843 voltage-gated cation channel activity
1.57 1.85e-02 GO:0005525 GTP binding
1.40 3.33e-02 GO:0043565 sequence-specific DNA binding
1.20 3.99e-02 GO:0003677 DNA binding