Motif ID: ZIC1..3.p2

Z-value: 2.303


Transcription factors associated with ZIC1..3.p2:

Gene SymbolEntrez IDGene Name
ZIC1 7545 Zic family member 1 (odd-paired homolog, Drosophila)
ZIC2 7546 Zic family member 2 (odd-paired homolog, Drosophila)
ZIC3 7547 Zic family member 3 (odd-paired homolog, Drosophila)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ZIC1chr3_+_1471271510.485.4e-14Click!
ZIC3chrX_+_1366483130.452.3e-12Click!


Activity profile for motif ZIC1..3.p2.

activity profile for motif ZIC1..3.p2


Sorted Z-values histogram for motif ZIC1..3.p2

Sorted Z-values for motif ZIC1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ZIC1..3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_-_6798419 65.491 ZNF384
zinc finger protein 384
chr11_-_111782447 65.049 NM_001885
CRYAB
crystallin, alpha B
chr12_-_45270071 52.149 NELL2
NEL-like 2 (chicken)
chr2_-_26205327 52.145 KIF3C
kinesin family member 3C
chr12_-_45269953 48.473 NELL2
NEL-like 2 (chicken)
chr6_-_29595934 48.184 NM_021903
GABBR1
gamma-aminobutyric acid (GABA) B receptor, 1
chr14_-_103988829 45.955 CKB
creatine kinase, brain
chr12_-_45270157 42.183 NM_001145108
NM_006159
NELL2

NEL-like 2 (chicken)

chr11_-_12030539 41.786 DKK3
dickkopf 3 homolog (Xenopus laevis)
chr14_+_29236882 36.194 FOXG1
forkhead box G1
chr12_+_79258588 35.682 SYT1
synaptotagmin I
chr5_+_175792444 35.381 NM_173664
ARL10
ADP-ribosylation factor-like 10
chrX_-_48858617 35.009 NM_020137
NM_207672
GRIPAP1

GRIP1 associated protein 1

chr14_-_103989195 34.950 NM_001823
CKB
creatine kinase, brain
chr14_+_101292483 33.021


chr12_+_79258517 32.851 SYT1
synaptotagmin I
chrX_-_13956445 32.266


chr11_-_12030622 31.941 NM_015881
DKK3
dickkopf 3 homolog (Xenopus laevis)
chr14_-_103989112 31.736 CKB
creatine kinase, brain
chr9_-_113800243 31.145 NM_001401
NM_057159
LPAR1

lysophosphatidic acid receptor 1

chr11_-_12030128 30.384 NM_001018057
DKK3
dickkopf 3 homolog (Xenopus laevis)
chr14_+_101292451 30.349 MEG3
maternally expressed 3 (non-protein coding)
chr1_-_38512446 30.092 NM_002699
POU3F1
POU class 3 homeobox 1
chr13_-_30881141 28.652 NM_001014380
KATNAL1
katanin p60 subunit A-like 1
chr12_-_49392909 27.765 NM_015086
DDN
dendrin
chr12_-_6798528 27.708 NM_133476
ZNF384
zinc finger protein 384
chr13_-_30881556 26.329 NM_032116
KATNAL1
katanin p60 subunit A-like 1
chr11_+_62439134 25.806 C11orf83
chromosome 11 open reading frame 83
chr6_-_29595746 25.805 GABBR1
gamma-aminobutyric acid (GABA) B receptor, 1
chr22_-_44258210 25.784 NM_014351
SULT4A1
sulfotransferase family 4A, member 1
chr7_-_150946031 25.638 SMARCD3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
chr11_+_62439120 25.373 NM_001085372
C11orf83
chromosome 11 open reading frame 83
chr5_+_71403040 25.142 NM_005909
MAP1B
microtubule-associated protein 1B
chr21_-_34100210 25.003 SYNJ1
synaptojanin 1
chr3_-_73673978 24.347 NM_015009
PDZRN3
PDZ domain containing ring finger 3
chr2_-_26205437 23.792 NM_002254
KIF3C
kinesin family member 3C
chr15_+_84115979 23.601 NM_003027
SH3GL3
SH3-domain GRB2-like 3
chr1_-_156217717 23.458 NM_198406
NM_024897
PAQR6

progestin and adipoQ receptor family member VI

chr6_-_6007632 23.203 NM_016588
NRN1
neuritin 1
chr12_-_6798619 23.177 NM_001039920
NM_001135734
ZNF384

zinc finger protein 384

chr12_+_79258794 22.967 SYT1
synaptotagmin I
chr12_-_45270632 22.857 NM_001145107
NELL2
NEL-like 2 (chicken)
chr15_+_74421698 22.196 NM_001130136
ISLR2
immunoglobulin superfamily containing leucine-rich repeat 2
chr15_+_74421986 21.859 NM_001130137
ISLR2
immunoglobulin superfamily containing leucine-rich repeat 2
chrX_-_107979606 21.762 NM_003604
IRS4
insulin receptor substrate 4
chr12_-_45269340 21.600 NM_001145109
NELL2
NEL-like 2 (chicken)
chr2_-_201936386 21.587 FAM126B
family with sequence similarity 126, member B
chr20_+_36149606 21.209 NM_005386
NM_181689
NNAT

neuronatin

chrX_-_51812249 21.181 NM_001098800
NM_001242362
NM_030801
NM_177535
NM_177537
MAGED4
MAGED4B



melanoma antigen family D, 4
melanoma antigen family D, 4B



chr17_+_40834571 20.989 NM_003632
CNTNAP1
contactin associated protein 1
chr6_-_29600959 20.828 NM_001470
NM_021904
GABBR1

gamma-aminobutyric acid (GABA) B receptor, 1

chr11_-_123525300 20.764 NM_001040151
NM_018400
SCN3B

sodium channel, voltage-gated, type III, beta

chrX_+_101906293 20.763 NM_001099410
NM_001099411
NM_014710
NM_001184727
GPRASP1



G protein-coupled receptor associated sorting protein 1



chr2_+_149633173 20.538


chr6_-_29600859 20.483 GABBR1
gamma-aminobutyric acid (GABA) B receptor, 1
chr6_-_29600668 20.331 GABBR1
gamma-aminobutyric acid (GABA) B receptor, 1
chrX_-_13956530 20.238 GPM6B
glycoprotein M6B
chr11_+_111783476 19.759 HSPB2-C11orf52
HSPB2
HSPB2-C11orf52 readthrough (non-protein coding)
heat shock 27kDa protein 2
chr5_+_161275541 19.486 NM_001127645
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr17_-_27278324 19.375 PHF12
PHD finger protein 12
chrX_+_134166318 19.372 NM_001078171
FAM127A
family with sequence similarity 127, member A
chr11_+_111783459 19.348 NM_001541
HSPB2-C11orf52
HSPB2
HSPB2-C11orf52 readthrough (non-protein coding)
heat shock 27kDa protein 2
chr12_-_53448167 19.303 LOC283335
uncharacterized LOC283335
chr14_-_21270537 19.055 NM_198232
RNASE1
ribonuclease, RNase A family, 1 (pancreatic)
chr9_+_130965666 18.736 DNM1
dynamin 1
chr14_+_65007418 18.401 HSPA2
heat shock 70kDa protein 2
chr12_-_122018858 18.142 NM_032590
KDM2B
lysine (K)-specific demethylase 2B
chr11_-_123524881 17.310 SCN3B
sodium channel, voltage-gated, type III, beta
chr11_-_117186918 17.154 NM_012104
NM_138971
NM_138972
NM_138973
BACE1



beta-site APP-cleaving enzyme 1



chr3_+_10028579 17.040 LOC442075
uncharacterized LOC442075
chr9_-_122131579 17.017 NM_014618
DBC1
deleted in bladder cancer 1
chr11_+_124609775 17.004 NM_001126181
NM_006176
NRGN

neurogranin (protein kinase C substrate, RC3)

chrX_+_103031797 16.791 PLP1
proteolipid protein 1
chr8_+_21916858 16.681 EPB49
erythrocyte membrane protein band 4.9 (dematin)
chrX_-_13956644 16.649 NM_001001994
GPM6B
glycoprotein M6B
chr7_-_108096693 16.622 NM_001193582
NM_001193583
NM_001193584
NM_005010
NRCAM



neuronal cell adhesion molecule



chr10_-_95360959 16.576 NM_006744
RBP4
retinol binding protein 4, plasma
chr11_+_124609841 16.569 NRGN
neurogranin (protein kinase C substrate, RC3)
chr7_-_99680358 16.499 ZNF3
zinc finger protein 3
chr9_+_130965608 16.411 NM_001005336
NM_004408
DNM1

dynamin 1

chr11_-_66115016 16.325 NM_006876
B3GNT1
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
chr3_+_10068123 16.162 FANCD2
Fanconi anemia, complementation group D2
chr20_+_44650260 16.015 NM_001134771
SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5
chrX_+_51927918 15.950 NM_001098800
NM_001242362
NM_030801
NM_177535
NM_177537
MAGED4
MAGED4B



melanoma antigen family D, 4
melanoma antigen family D, 4B



chr21_-_34100316 15.949 NM_003895
NM_203446
SYNJ1

synaptojanin 1

chr16_+_6533758 15.867 RBFOX1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr17_-_7197896 15.778 YBX2
Y box binding protein 2
chrX_+_70443055 15.571 NM_000166
GJB1
gap junction protein, beta 1, 32kDa
chrX_+_13671224 15.546 NM_152634
TCEANC
transcription elongation factor A (SII) N-terminal and central domain containing
chr9_+_130965668 15.541 DNM1
dynamin 1
chr3_-_10067989 15.508 CIDECP
cell death-inducing DFFA-like effector c pseudogene
chr17_-_5404304 15.503 NM_001162371
LOC728392
uncharacterized LOC728392
chr17_-_7197811 15.499 YBX2
Y box binding protein 2
chr9_-_123476578 15.418 NM_001080497
MEGF9
multiple EGF-like-domains 9
chr3_+_10068097 15.375 NM_001018115
NM_033084
FANCD2

Fanconi anemia, complementation group D2

chr19_-_46295647 15.260 DMWD
dystrophia myotonica, WD repeat containing
chrX_+_70364707 15.241 NLGN3
neuroligin 3
chr8_+_21916685 15.237 NM_001114138
NM_001978
EPB49

erythrocyte membrane protein band 4.9 (dematin)

chr4_-_176733901 15.229 GPM6A
glycoprotein M6A
chr14_+_101193313 15.216 DLK1
delta-like 1 homolog (Drosophila)
chr10_-_90712510 14.985 NM_001613
ACTA2
actin, alpha 2, smooth muscle, aorta
chr21_-_34100228 14.967 NM_001160302
NM_001160306
SYNJ1

synaptojanin 1

chr12_+_13197284 14.710 NM_020853
KIAA1467
KIAA1467
chr3_-_195306274 14.659 APOD
apolipoprotein D
chr14_-_24584125 14.650 NRL
neural retina leucine zipper
chr19_+_58790306 14.549 NM_021089
ZNF8
zinc finger protein 8
chr14_-_51561657 14.480 TRIM9
tripartite motif containing 9
chr14_+_29236171 14.421 NM_005249
FOXG1
forkhead box G1
chr1_-_150602047 14.412 ENSA
endosulfine alpha
chr12_+_48499655 14.396 NM_001166686
PFKM
phosphofructokinase, muscle
chr17_-_7197866 14.303 NM_015982
YBX2
Y box binding protein 2
chr3_-_149688638 14.156 NM_002628
NM_053024
PFN2

profilin 2

chr14_+_65007163 14.110 NM_021979
HSPA2
heat shock 70kDa protein 2
chr16_+_69796237 14.073 NM_007014
NM_199423
WWP2

WW domain containing E3 ubiquitin protein ligase 2

chr15_-_83316621 13.973 NM_030594
CPEB1
cytoplasmic polyadenylation element binding protein 1
chr2_+_17935124 13.949 NM_182625
GEN1
Gen endonuclease homolog 1 (Drosophila)
chr2_+_25016174 13.816 NM_001199803
NM_024322
CENPO

centromere protein O

chr19_-_47164289 13.805 NM_145056
DACT3
dapper, antagonist of beta-catenin, homolog 3 (Xenopus laevis)
chr3_+_184053682 13.790 NM_001171093
FAM131A
family with sequence similarity 131, member A
chrX_+_70364728 13.736 NLGN3
neuroligin 3
chr1_+_99730067 13.700 LPPR4
lipid phosphate phosphatase-related protein type 4
chr15_+_84116172 13.576 SH3GL3
SH3-domain GRB2-like 3
chr15_+_41851153 13.496 NM_006293
TYRO3
TYRO3 protein tyrosine kinase
chr1_-_27930360 13.472 AHDC1
AT hook, DNA binding motif, containing 1
chr2_-_241500459 13.468 ANKMY1
ankyrin repeat and MYND domain containing 1
chr19_+_35521591 13.424 NM_001037
NM_199037
SCN1B

sodium channel, voltage-gated, type I, beta

chr22_-_18484183 13.419 MICAL3
microtubule associated monoxygenase, calponin and LIM domain containing 3
chr5_+_140346053 13.388 PCDHAC2
protocadherin alpha subfamily C, 2
chr3_-_149688886 13.384 PFN2
profilin 2
chr5_-_11904127 13.375 CTNND2
catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)
chr1_-_85930610 13.351 DDAH1
dimethylarginine dimethylaminohydrolase 1
chr7_-_150945731 13.280 NM_001003801
SMARCD3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
chr17_-_80656461 13.227 NM_006822
RAB40B
RAB40B, member RAS oncogene family
chr1_+_155829259 13.223 NM_152280
SYT11
synaptotagmin XI
chr16_+_55542909 13.223 NM_017839
LPCAT2
lysophosphatidylcholine acyltransferase 2
chr5_+_140346289 13.146 NM_031883
PCDHAC2
protocadherin alpha subfamily C, 2
chr1_-_241520384 13.120 RGS7
regulator of G-protein signaling 7
chr17_-_8066254 13.109 NM_014232
VAMP2
vesicle-associated membrane protein 2 (synaptobrevin 2)
chr1_-_241520467 13.095 NM_002924
RGS7
regulator of G-protein signaling 7
chr3_+_50306305 13.086 SEMA3B
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
chrX_+_70364680 13.059 NM_001166660
NM_018977
NM_181303
NLGN3


neuroligin 3


chr2_-_237172987 13.020 NM_212556
ASB18
ankyrin repeat and SOCS box containing 18
chr8_+_19796730 13.012 LPL
lipoprotein lipase
chr12_+_112451229 12.937


chr3_+_49591897 12.852 NM_003458
BSN
bassoon (presynaptic cytomatrix protein)
chr16_-_31483425 12.825


chrX_-_138287180 12.807 NM_001139498
NM_001139500
NM_001139501
FGF13


fibroblast growth factor 13


chr7_+_64498643 12.766 CCT6P3
chaperonin containing TCP1, subunit 6 (zeta) pseudogene 3
chr17_-_37557851 12.743 NM_001184906
NM_032875
FBXL20

F-box and leucine-rich repeat protein 20

chrX_-_15872871 12.652 AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr14_+_101193190 12.591 NM_003836
DLK1
delta-like 1 homolog (Drosophila)
chr17_+_7554415 12.586 ATP1B2
ATPase, Na+/K+ transporting, beta 2 polypeptide
chr1_+_2005083 12.577 NM_001033581
PRKCZ
protein kinase C, zeta
chr19_+_35634153 12.534 NM_022006
FXYD7
FXYD domain containing ion transport regulator 7
chr12_+_117176085 12.511 NM_001109903
NM_032814
RNFT2

ring finger protein, transmembrane 2

chr19_+_45417576 12.479 APOC1
apolipoprotein C-I
chrX_+_102000906 12.413 NM_001142529
NM_001142530
BHLHB9

basic helix-loop-helix domain containing, class B, 9

chrX_-_140271275 12.371 LDOC1
leucine zipper, down-regulated in cancer 1
chr11_+_65554504 12.310 NM_004561
OVOL1
ovo-like 1(Drosophila)
chr6_-_110500803 12.307 WASF1
WAS protein family, member 1
chr20_+_24450269 12.306 SYNDIG1
synapse differentiation inducing 1
chr19_+_7694658 12.260 NM_001171155
C19orf79
chromosome 19 open reading frame 79
chr8_+_19796581 12.170 NM_000237
LPL
lipoprotein lipase
chr5_-_168727715 12.153 NM_003062
SLIT3
slit homolog 3 (Drosophila)
chr4_-_176734181 12.080 NM_201591
GPM6A
glycoprotein M6A
chrX_-_48931645 12.057 NM_007213
PRAF2
PRA1 domain family, member 2
chr4_+_72052354 11.999 NM_001098484
NM_001134742
SLC4A4

solute carrier family 4, sodium bicarbonate cotransporter, member 4

chr4_-_174450529 11.938 HAND2
heart and neural crest derivatives expressed 2
chr7_+_65338161 11.936 NM_173517
VKORC1L1
vitamin K epoxide reductase complex, subunit 1-like 1
chr21_-_33104210 11.934 SCAF4
SR-related CTD-associated factor 4
chr20_+_42143045 11.930 NM_015478
L3MBTL1
l(3)mbt-like 1 (Drosophila)
chr4_-_5890266 11.870 NM_001313
CRMP1
collapsin response mediator protein 1
chr4_-_102267952 11.789 PPP3CA
protein phosphatase 3, catalytic subunit, alpha isozyme
chr16_-_74401991 11.772 LOC283922
pyruvate dehydrogenase phosphatase regulatory subunit pseudogene
chr10_+_52751114 11.763 PRKG1
protein kinase, cGMP-dependent, type I
chr1_+_2005424 11.685 NM_001242874
PRKCZ
protein kinase C, zeta
chr7_-_123388711 11.652 NM_003941
WASL
Wiskott-Aldrich syndrome-like
chr5_-_851100 11.643 NM_024786
ZDHHC11
zinc finger, DHHC-type containing 11
chr9_+_124061880 11.608 NM_000177
GSN
gelsolin
chr3_-_9885695 11.544 NM_001142547
NM_173659
RPUSD3

RNA pseudouridylate synthase domain containing 3

chr1_+_36690038 11.539 THRAP3
thyroid hormone receptor associated protein 3
chr17_+_7554711 11.401 ATP1B2
ATPase, Na+/K+ transporting, beta 2 polypeptide
chr17_+_7608413 11.397 NM_001406
EFNB3
ephrin-B3
chr11_+_64851731 11.370 ZFPL1
zinc finger protein-like 1
chr3_+_101568325 11.292 NM_031419
NFKBIZ
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
chr8_+_1922030 11.275 NM_014867
KBTBD11
kelch repeat and BTB (POZ) domain containing 11
chr22_-_19511777 11.239 CLDN5
claudin 5
chr19_-_46295785 11.231 NM_004943
DMWD
dystrophia myotonica, WD repeat containing
chr11_-_65640199 11.193 NM_016938
EFEMP2
EGF containing fibulin-like extracellular matrix protein 2
chr14_+_101193275 11.102 DLK1
delta-like 1 homolog (Drosophila)
chr1_-_150602089 11.100 NM_004436
NM_207042
NM_207043
NM_207044
NM_207168
ENSA




endosulfine alpha




chr12_+_79257772 11.056 NM_001135805
SYT1
synaptotagmin I
chr11_+_63606598 11.038 MARK2
MAP/microtubule affinity-regulating kinase 2
chr15_+_45879575 11.037 PLDN
pallidin homolog (mouse)
chr7_-_129251465 10.964


chr2_+_17935379 10.949 NM_001130009
GEN1
Gen endonuclease homolog 1 (Drosophila)
chr6_+_151561508 10.948 AKAP12
A kinase (PRKA) anchor protein 12
chr19_-_49149252 10.920 NM_001217
CA11
carbonic anhydrase XI
chr6_+_41040713 10.865 NFYA
nuclear transcription factor Y, alpha
chr1_+_36689996 10.855 NM_005119
THRAP3
thyroid hormone receptor associated protein 3

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.49 1.32e-23 GO:0032502 developmental process
1.49 1.88e-22 GO:0023052 signaling
1.27 1.31e-21 GO:0065007 biological regulation
1.53 6.00e-21 GO:0048856 anatomical structure development
1.49 1.48e-20 GO:0007275 multicellular organismal development
1.36 3.00e-20 GO:0032501 multicellular organismal process
1.29 5.80e-20 GO:0050794 regulation of cellular process
1.54 2.26e-19 GO:0048731 system development
1.63 3.38e-18 GO:0048869 cellular developmental process
1.64 7.09e-18 GO:0030154 cell differentiation
1.26 9.83e-18 GO:0050789 regulation of biological process
1.74 5.26e-16 GO:0007399 nervous system development
1.73 9.56e-16 GO:0009653 anatomical structure morphogenesis
1.14 1.92e-14 GO:0009987 cellular process
1.41 9.02e-14 GO:0007165 signal transduction
2.27 1.82e-13 GO:0019226 transmission of nerve impulse
2.27 1.82e-13 GO:0035637 multicellular organismal signaling
1.58 6.01e-11 GO:0023051 regulation of signaling
1.90 6.67e-11 GO:0007267 cell-cell signaling
1.78 2.86e-10 GO:0048468 cell development
2.18 5.27e-10 GO:0007268 synaptic transmission
1.78 1.97e-09 GO:0009888 tissue development
1.30 2.55e-09 GO:0051716 cellular response to stimulus
1.78 2.98e-09 GO:0048699 generation of neurons
1.87 4.73e-09 GO:0030182 neuron differentiation
1.49 4.79e-09 GO:0048513 organ development
1.74 5.09e-09 GO:0022008 neurogenesis
1.39 5.18e-09 GO:0048518 positive regulation of biological process
1.69 7.70e-09 GO:0007154 cell communication
1.41 1.40e-08 GO:0048522 positive regulation of cellular process
1.47 3.33e-08 GO:0048583 regulation of response to stimulus
1.92 3.93e-08 GO:0048666 neuron development
1.55 5.38e-08 GO:0009966 regulation of signal transduction
1.73 6.24e-08 GO:0009891 positive regulation of biosynthetic process
2.65 7.42e-08 GO:0048732 gland development
1.70 7.99e-08 GO:0050793 regulation of developmental process
1.67 1.04e-07 GO:0032879 regulation of localization
1.77 1.35e-07 GO:0010557 positive regulation of macromolecule biosynthetic process
1.72 1.38e-07 GO:0031328 positive regulation of cellular biosynthetic process
2.04 1.42e-07 GO:0048667 cell morphogenesis involved in neuron differentiation
1.57 1.47e-07 GO:0051239 regulation of multicellular organismal process
1.96 1.97e-07 GO:0000904 cell morphogenesis involved in differentiation
1.30 2.70e-07 GO:0031323 regulation of cellular metabolic process
1.86 2.77e-07 GO:0009887 organ morphogenesis
2.04 2.90e-07 GO:0007409 axonogenesis
1.65 3.44e-07 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.36 3.60e-07 GO:0009889 regulation of biosynthetic process
1.41 3.82e-07 GO:0065008 regulation of biological quality
1.62 4.20e-07 GO:0010646 regulation of cell communication
2.17 4.75e-07 GO:0007411 axon guidance
1.36 4.81e-07 GO:0031326 regulation of cellular biosynthetic process
1.55 7.79e-07 GO:0009893 positive regulation of metabolic process
1.27 8.44e-07 GO:0019222 regulation of metabolic process
1.72 9.09e-07 GO:0051173 positive regulation of nitrogen compound metabolic process
1.73 9.18e-07 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.52 9.18e-07 GO:0035556 intracellular signal transduction
1.20 9.64e-07 GO:0050896 response to stimulus
1.77 1.08e-06 GO:0010628 positive regulation of gene expression
2.16 1.30e-06 GO:0001501 skeletal system development
1.76 1.35e-06 GO:0009790 embryo development
1.35 1.70e-06 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.55 1.89e-06 GO:0031325 positive regulation of cellular metabolic process
1.78 1.94e-06 GO:0007167 enzyme linked receptor protein signaling pathway
1.96 2.04e-06 GO:0048812 neuron projection morphogenesis
1.29 2.42e-06 GO:0080090 regulation of primary metabolic process
1.88 2.49e-06 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.55 3.30e-06 GO:0010604 positive regulation of macromolecule metabolic process
1.70 3.94e-06 GO:2000026 regulation of multicellular organismal development
1.80 4.06e-06 GO:0000902 cell morphogenesis
1.89 4.32e-06 GO:0030001 metal ion transport
1.77 5.22e-06 GO:0045893 positive regulation of transcription, DNA-dependent
1.63 5.28e-06 GO:0006811 ion transport
1.38 7.09e-06 GO:0048523 negative regulation of cellular process
2.00 1.08e-05 GO:0048598 embryonic morphogenesis
1.86 1.34e-05 GO:0031175 neuron projection development
1.32 1.82e-05 GO:0051171 regulation of nitrogen compound metabolic process
1.41 2.33e-05 GO:0007166 cell surface receptor linked signaling pathway
1.77 2.80e-05 GO:0006812 cation transport
2.02 2.81e-05 GO:0007389 pattern specification process
2.07 3.12e-05 GO:0022603 regulation of anatomical structure morphogenesis
1.33 3.27e-05 GO:0010556 regulation of macromolecule biosynthetic process
1.82 3.30e-05 GO:0048858 cell projection morphogenesis
1.72 3.86e-05 GO:0032989 cellular component morphogenesis
1.69 4.97e-05 GO:0045595 regulation of cell differentiation
1.81 5.11e-05 GO:0032990 cell part morphogenesis
1.34 5.69e-05 GO:0048519 negative regulation of biological process
1.80 5.69e-05 GO:0007417 central nervous system development
1.26 6.05e-05 GO:0051179 localization
2.10 6.80e-05 GO:0035295 tube development
1.33 6.91e-05 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.68 7.32e-05 GO:0051254 positive regulation of RNA metabolic process
1.35 9.14e-05 GO:0006355 regulation of transcription, DNA-dependent
1.26 1.11e-04 GO:0016043 cellular component organization
1.26 1.13e-04 GO:0060255 regulation of macromolecule metabolic process
1.80 1.85e-04 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.57 2.13e-04 GO:0006351 transcription, DNA-dependent
1.76 2.19e-04 GO:0006935 chemotaxis
1.76 2.19e-04 GO:0042330 taxis
1.57 2.26e-04 GO:0040011 locomotion
1.54 2.39e-04 GO:0042127 regulation of cell proliferation
2.04 2.99e-04 GO:0007423 sensory organ development
1.81 3.27e-04 GO:0051094 positive regulation of developmental process
2.73 4.05e-04 GO:0048736 appendage development
2.73 4.05e-04 GO:0060173 limb development
2.44 4.34e-04 GO:0031344 regulation of cell projection organization
2.13 5.53e-04 GO:0051129 negative regulation of cellular component organization
2.74 5.56e-04 GO:0035107 appendage morphogenesis
2.74 5.56e-04 GO:0035108 limb morphogenesis
1.94 5.62e-04 GO:0051093 negative regulation of developmental process
1.99 6.78e-04 GO:0051270 regulation of cellular component movement
1.76 7.77e-04 GO:0072358 cardiovascular system development
1.76 7.77e-04 GO:0072359 circulatory system development
2.69 8.96e-04 GO:0061138 morphogenesis of a branching epithelium
2.11 8.97e-04 GO:0002009 morphogenesis of an epithelium
1.79 9.03e-04 GO:0032583 regulation of gene-specific transcription
1.85 9.33e-04 GO:0009792 embryo development ending in birth or egg hatching
1.31 1.05e-03 GO:0051252 regulation of RNA metabolic process
2.89 1.16e-03 GO:0030879 mammary gland development
2.08 1.16e-03 GO:0003002 regionalization
1.85 1.27e-03 GO:0043009 chordate embryonic development
2.37 1.31e-03 GO:0043062 extracellular structure organization
1.84 1.31e-03 GO:0060429 epithelium development
1.31 1.37e-03 GO:0042221 response to chemical stimulus
1.96 1.39e-03 GO:0001944 vasculature development
1.28 1.42e-03 GO:0010468 regulation of gene expression
2.50 1.55e-03 GO:0001763 morphogenesis of a branching structure
1.62 1.97e-03 GO:0030030 cell projection organization
2.00 2.02e-03 GO:0045596 negative regulation of cell differentiation
1.93 2.16e-03 GO:0048729 tissue morphogenesis
1.96 2.33e-03 GO:0051960 regulation of nervous system development
1.53 2.45e-03 GO:0051128 regulation of cellular component organization
1.23 2.55e-03 GO:0071840 cellular component organization or biogenesis
2.28 2.75e-03 GO:0009952 anterior/posterior pattern formation
1.74 2.78e-03 GO:0055082 cellular chemical homeostasis
1.62 2.93e-03 GO:0048878 chemical homeostasis
1.74 3.05e-03 GO:0023057 negative regulation of signaling
1.93 3.19e-03 GO:0040012 regulation of locomotion
1.74 3.37e-03 GO:0010648 negative regulation of cell communication
1.25 3.89e-03 GO:0051234 establishment of localization
1.56 4.36e-03 GO:0051049 regulation of transport
1.70 4.50e-03 GO:0050801 ion homeostasis
2.70 5.19e-03 GO:0030326 embryonic limb morphogenesis
2.70 5.19e-03 GO:0035113 embryonic appendage morphogenesis
1.73 5.48e-03 GO:0006873 cellular ion homeostasis
2.36 6.09e-03 GO:0060191 regulation of lipase activity
1.80 6.17e-03 GO:0007420 brain development
1.95 6.51e-03 GO:0008361 regulation of cell size
2.94 6.55e-03 GO:0050770 regulation of axonogenesis
1.85 6.60e-03 GO:0060284 regulation of cell development
4.04 7.03e-03 GO:0030516 regulation of axon extension
1.93 7.84e-03 GO:0001568 blood vessel development
2.36 8.54e-03 GO:0048705 skeletal system morphogenesis
2.01 8.78e-03 GO:0048011 nerve growth factor receptor signaling pathway
1.33 9.20e-03 GO:0003008 system process
1.82 1.06e-02 GO:0015672 monovalent inorganic cation transport
1.24 1.08e-02 GO:0006810 transport
1.73 1.08e-02 GO:0009968 negative regulation of signal transduction
1.36 1.28e-02 GO:0065009 regulation of molecular function
3.34 1.39e-02 GO:0010594 regulation of endothelial cell migration
2.82 1.45e-02 GO:0022612 gland morphogenesis
1.80 1.47e-02 GO:0045597 positive regulation of cell differentiation
2.04 1.63e-02 GO:0045664 regulation of neuron differentiation
1.91 1.68e-02 GO:0030334 regulation of cell migration
1.61 1.82e-02 GO:0019725 cellular homeostasis
1.99 1.93e-02 GO:0048514 blood vessel morphogenesis
1.93 1.93e-02 GO:0050767 regulation of neurogenesis
1.25 2.38e-02 GO:0071842 cellular component organization at cellular level
1.88 2.41e-02 GO:2000145 regulation of cell motility
2.17 2.43e-02 GO:0048562 embryonic organ morphogenesis
2.07 2.49e-02 GO:0035239 tube morphogenesis
1.94 2.51e-02 GO:0048568 embryonic organ development
1.62 2.64e-02 GO:0048585 negative regulation of response to stimulus
2.31 2.91e-02 GO:0010975 regulation of neuron projection development
3.46 3.06e-02 GO:0051149 positive regulation of muscle cell differentiation
1.73 3.11e-02 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
4.10 3.13e-02 GO:0043535 regulation of blood vessel endothelial cell migration
1.92 3.23e-02 GO:0006897 endocytosis
1.92 3.23e-02 GO:0010324 membrane invagination
1.45 3.27e-02 GO:0042592 homeostatic process
2.77 3.27e-02 GO:0048638 regulation of developmental growth
1.67 3.30e-02 GO:0060341 regulation of cellular localization
2.25 3.50e-02 GO:0001503 ossification
5.19 3.85e-02 GO:0043536 positive regulation of blood vessel endothelial cell migration
1.42 4.05e-02 GO:0032774 RNA biosynthetic process
1.49 4.15e-02 GO:0007155 cell adhesion
1.49 4.15e-02 GO:0022610 biological adhesion
2.73 4.18e-02 GO:0010721 negative regulation of cell development
2.19 4.84e-02 GO:0050678 regulation of epithelial cell proliferation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.55 4.70e-16 GO:0044459 plasma membrane part
1.60 2.13e-09 GO:0005887 integral to plasma membrane
1.28 2.15e-09 GO:0071944 cell periphery
1.28 2.51e-09 GO:0005886 plasma membrane
1.58 3.81e-09 GO:0031226 intrinsic to plasma membrane
2.74 7.26e-07 GO:0034703 cation channel complex
2.35 7.79e-07 GO:0034702 ion channel complex
1.63 2.23e-04 GO:0030054 cell junction
1.51 4.24e-04 GO:0005626 insoluble fraction
1.71 1.42e-03 GO:0045202 synapse
1.41 1.82e-03 GO:0000267 cell fraction
1.47 2.76e-03 GO:0005624 membrane fraction
1.69 3.33e-03 GO:0043005 neuron projection
1.45 4.26e-03 GO:0042995 cell projection
2.44 1.61e-02 GO:0008076 voltage-gated potassium channel complex
2.44 1.61e-02 GO:0034705 potassium channel complex
1.42 3.00e-02 GO:0031410 cytoplasmic vesicle
1.70 3.41e-02 GO:0044456 synapse part
1.91 3.55e-02 GO:0031252 cell leading edge
1.43 3.69e-02 GO:0016023 cytoplasmic membrane-bounded vesicle
2.60 4.68e-02 GO:0031256 leading edge membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.68 2.92e-09 GO:0001071 nucleic acid binding transcription factor activity
1.68 2.92e-09 GO:0003700 sequence-specific DNA binding transcription factor activity
1.82 6.39e-09 GO:0043565 sequence-specific DNA binding
1.10 7.22e-09 GO:0005488 binding
2.31 3.69e-08 GO:0005261 cation channel activity
1.86 7.35e-08 GO:0008324 cation transmembrane transporter activity
2.73 5.64e-07 GO:0022843 voltage-gated cation channel activity
1.56 2.78e-06 GO:0030528 transcription regulator activity
1.66 3.41e-06 GO:0015075 ion transmembrane transporter activity
1.91 6.89e-06 GO:0005216 ion channel activity
1.15 1.13e-05 GO:0005515 protein binding
1.87 1.21e-05 GO:0015267 channel activity
2.03 1.22e-05 GO:0022836 gated channel activity
1.87 1.36e-05 GO:0022803 passive transmembrane transporter activity
1.89 1.42e-05 GO:0022838 substrate-specific channel activity
2.32 1.90e-05 GO:0005244 voltage-gated ion channel activity
2.32 1.90e-05 GO:0022832 voltage-gated channel activity
1.49 4.86e-04 GO:0022857 transmembrane transporter activity
1.50 6.08e-04 GO:0022891 substrate-specific transmembrane transporter activity
2.88 8.78e-04 GO:0005262 calcium channel activity
2.06 1.48e-03 GO:0000975 regulatory region DNA binding
2.06 1.48e-03 GO:0001067 regulatory region nucleic acid binding
2.06 1.48e-03 GO:0044212 transcription regulatory region DNA binding
3.25 1.51e-03 GO:0004879 ligand-dependent nuclear receptor activity
3.26 2.67e-03 GO:0003707 steroid hormone receptor activity
2.05 2.87e-03 GO:0010843 promoter binding
1.80 3.60e-03 GO:0016563 transcription activator activity
1.60 1.57e-02 GO:0030695 GTPase regulator activity
4.89 1.81e-02 GO:0005212 structural constituent of eye lens
5.28 2.56e-02 GO:0005248 voltage-gated sodium channel activity
2.31 3.90e-02 GO:0005057 receptor signaling protein activity
1.56 4.01e-02 GO:0060589 nucleoside-triphosphatase regulator activity
1.37 4.50e-02 GO:0022892 substrate-specific transporter activity
1.72 4.77e-02 GO:0005083 small GTPase regulator activity