Motif ID: ZNF148.p2

Z-value: 1.768


Transcription factors associated with ZNF148.p2:

Gene SymbolEntrez IDGene Name
ZNF148 7707 zinc finger protein 148

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ZNF148chr3_-_1250940030.171.2e-02Click!


Activity profile for motif ZNF148.p2.

activity profile for motif ZNF148.p2


Sorted Z-values histogram for motif ZNF148.p2

Sorted Z-values for motif ZNF148.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ZNF148.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_31704070 27.174 CLIC1
chloride intracellular channel 1
chr2_-_10588273 25.521 ODC1
ornithine decarboxylase 1
chr6_-_31704093 25.509 CLIC1
chloride intracellular channel 1
chr20_+_3776905 24.544 CDC25B
cell division cycle 25 homolog B (S. pombe)
chr1_+_26606443 24.487 SH3BGRL3
SH3 domain binding glutamic acid-rich protein like 3
chr4_-_2936458 23.200 MFSD10
major facilitator superfamily domain containing 10
chr1_+_26606586 22.622 SH3BGRL3
SH3 domain binding glutamic acid-rich protein like 3
chr1_+_26606580 21.793 SH3BGRL3
SH3 domain binding glutamic acid-rich protein like 3
chrX_-_153599719 21.648 FLNA
filamin A, alpha
chr2_-_10588451 21.288 NM_002539
ODC1
ornithine decarboxylase 1
chr1_+_26606621 21.152 SH3BGRL3
SH3 domain binding glutamic acid-rich protein like 3
chr19_+_35645640 20.789 NM_144779
NM_001164605
FXYD5

FXYD domain containing ion transport regulator 5

chr19_+_35645614 20.311 NM_014164
FXYD5
FXYD domain containing ion transport regulator 5
chr4_-_2935851 19.916 NM_001120
MFSD10
major facilitator superfamily domain containing 10
chr4_-_2936563 19.894 NM_001146069
MFSD10
major facilitator superfamily domain containing 10
chr11_-_64014407 19.743 NM_138689
PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr11_-_64014381 19.604 PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chrX_-_153599581 19.601 FLNA
filamin A, alpha
chr11_-_64014264 18.834 PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr6_+_32821924 18.456 NM_002800
PSMB9
proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)
chr19_+_35646006 17.996 FXYD5
FXYD domain containing ion transport regulator 5
chrX_-_152989822 17.046 NM_005745
BCAP31
B-cell receptor-associated protein 31
chr22_-_36925212 16.630 EIF3D
eukaryotic translation initiation factor 3, subunit D
chr22_-_36783851 16.598 MYH9
myosin, heavy chain 9, non-muscle
chrX_-_153602998 16.503 NM_001110556
NM_001456
FLNA

filamin A, alpha

chr19_-_2038937 16.258 MKNK2
MAP kinase interacting serine/threonine kinase 2
chr4_-_2935650 16.096 MFSD10
major facilitator superfamily domain containing 10
chrX_-_152989851 16.024 BCAP31
B-cell receptor-associated protein 31
chr3_-_185542807 15.864 NM_001007225
NM_006548
IGF2BP2

insulin-like growth factor 2 mRNA binding protein 2

chr22_-_36925270 15.697 NM_003753
EIF3D
eukaryotic translation initiation factor 3, subunit D
chr19_-_41859830 15.696 NM_000660
TGFB1
transforming growth factor, beta 1
chr6_-_32821592 15.692 TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr22_-_36925138 15.273 EIF3D
eukaryotic translation initiation factor 3, subunit D
chr19_-_2046229 15.150 MKNK2
MAP kinase interacting serine/threonine kinase 2
chr18_+_12308236 14.683 TUBB6
tubulin, beta 6 class V
chr22_-_36783977 14.635 MYH9
myosin, heavy chain 9, non-muscle
chr2_+_85132762 14.623 NM_021103
TMSB10
thymosin beta 10
chr2_+_181845605 14.434 UBE2E3
ubiquitin-conjugating enzyme E2E 3
chr6_-_31704281 14.417 CLIC1
chloride intracellular channel 1
chr6_-_32821743 14.256 NM_000593
TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr6_-_31704318 14.168 NM_001288
CLIC1
chloride intracellular channel 1
chr6_-_31704287 14.066 CLIC1
chloride intracellular channel 1
chr7_+_98972351 14.012 ARPC1B
actin related protein 2/3 complex, subunit 1B, 41kDa
chr6_-_31704272 13.913 CLIC1
chloride intracellular channel 1
chr19_+_50180408 13.864 NM_001207042
NM_001536
NM_198318
PRMT1


protein arginine methyltransferase 1


chr11_+_844062 13.766 NM_001025234
TSPAN4
tetraspanin 4
chr12_-_122231554 13.529 NM_019034
RHOF
ras homolog gene family, member F (in filopodia)
chr2_-_85637473 13.505 CAPG
capping protein (actin filament), gelsolin-like
chr22_-_36925175 13.313 EIF3D
eukaryotic translation initiation factor 3, subunit D
chr13_+_28196029 13.312 POLR1D
polymerase (RNA) I polypeptide D, 16kDa
chr13_+_28196004 13.291 POLR1D
polymerase (RNA) I polypeptide D, 16kDa
chr3_+_49711434 13.063 NM_001640
APEH
N-acylaminoacyl-peptide hydrolase
chr13_+_28196024 13.004 POLR1D
polymerase (RNA) I polypeptide D, 16kDa
chrX_-_152989807 12.980


chr3_-_185542744 12.880 IGF2BP2
insulin-like growth factor 2 mRNA binding protein 2
chr22_-_36784001 12.767 MYH9
myosin, heavy chain 9, non-muscle
chr22_-_36784055 12.576 NM_002473
MYH9
myosin, heavy chain 9, non-muscle
chr11_-_46142955 12.563 NM_001101802
NM_016621
PHF21A

PHD finger protein 21A

chr19_+_50180492 12.526 PRMT1
protein arginine methyltransferase 1
chr11_+_64948685 12.494 NM_001198868
CAPN1
calpain 1, (mu/I) large subunit
chr19_+_48828820 12.477 EMP3
epithelial membrane protein 3
chr12_+_53342842 12.410 NM_000224
KRT18
keratin 18
chr18_+_12308242 12.342 NM_032525
TUBB6
tubulin, beta 6 class V
chr3_-_32544358 12.303 NM_017801
CMTM6
CKLF-like MARVEL transmembrane domain containing 6
chr6_-_4135701 12.036 NM_001166010
NM_006117
NM_206836
ECI2


enoyl-CoA delta isomerase 2


chr2_-_20424627 11.980 NM_002997
SDC1
syndecan 1
chr19_-_41859519 11.914 TGFB1
transforming growth factor, beta 1
chr17_-_62657997 11.828 SMURF2
SMAD specific E3 ubiquitin protein ligase 2
chr12_-_46662779 11.813 SLC38A1
solute carrier family 38, member 1
chr17_-_62658311 11.719 NM_022739
SMURF2
SMAD specific E3 ubiquitin protein ligase 2
chr13_+_28195913 11.612 NM_015972
NM_152705
POLR1D

polymerase (RNA) I polypeptide D, 16kDa

chrX_+_154114609 11.559 NM_001007523
NM_001007524
NM_012151
F8A2
F8A3
F8A1
coagulation factor VIII-associated 2
coagulation factor VIII-associated 3
coagulation factor VIII-associated 1
chr12_-_46662709 11.401 SLC38A1
solute carrier family 38, member 1
chr6_+_34204690 11.373 HMGA1
high mobility group AT-hook 1
chr7_+_98972326 11.331 ARPC1B
actin related protein 2/3 complex, subunit 1B, 41kDa
chr19_-_41859332 11.283 TGFB1
transforming growth factor, beta 1
chr12_-_109125289 11.160 NM_014325
CORO1C
coronin, actin binding protein, 1C
chr3_+_50273745 11.157 GNAI2
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
chr13_-_99229037 11.066 STK24
serine/threonine kinase 24
chr7_-_65447233 10.927 NM_000181
GUSB
glucuronidase, beta
chr12_-_109125275 10.823 CORO1C
coronin, actin binding protein, 1C
chr9_-_113018802 10.816 TXN
thioredoxin
chr1_+_32757707 10.544 NM_004964
HDAC1
histone deacetylase 1
chr15_+_90931470 10.452 NM_003870
IQGAP1
IQ motif containing GTPase activating protein 1
chr1_-_33283632 10.362 NM_003680
YARS
tyrosyl-tRNA synthetase
chr5_-_176900653 10.226 NM_004395
DBN1
drebrin 1
chr5_+_122110778 10.172 SNX2
sorting nexin 2
chr12_-_2986299 10.135 NM_001243088
NM_001243089
NM_021953
NM_202002
NM_202003
FOXM1




forkhead box M1




chr14_-_106092256 10.087 IGHG4
immunoglobulin heavy constant gamma 4 (G4m marker)
chr9_-_113018711 10.061 TXN
thioredoxin
chr1_+_948846 10.004 NM_005101
ISG15
ISG15 ubiquitin-like modifier
chr15_-_60690115 9.962 NM_001002857
NM_001002858
NM_001136015
NM_004039
ANXA2



annexin A2



chrX_-_153602928 9.960 FLNA
filamin A, alpha
chr1_-_8939150 9.918 NM_001428
ENO1
enolase 1, (alpha)
chr16_+_30194730 9.891 NM_001193333
NM_007074
CORO1A

coronin, actin binding protein, 1A

chr3_+_49711751 9.890 APEH
N-acylaminoacyl-peptide hydrolase
chr16_+_30194925 9.880 CORO1A
coronin, actin binding protein, 1A
chr12_-_46662533 9.878 SLC38A1
solute carrier family 38, member 1
chr21_-_40721010 9.774 NM_004965
HMGN1
high mobility group nucleosome binding domain 1
chr2_+_85132999 9.735 TMSB10
thymosin beta 10
chr2_+_181845088 9.709 NM_182678
NM_006357
UBE2E3

ubiquitin-conjugating enzyme E2E 3

chr7_+_26240830 9.699 NM_007276
CBX3
chromobox homolog 3
chr7_-_65447206 9.688 GUSB
glucuronidase, beta
chr2_-_32235603 9.565 NM_001137602
NM_015955
MEMO1

mediator of cell motility 1

chr19_-_50143350 9.438 NM_006270
RRAS
related RAS viral (r-ras) oncogene homolog
chr1_-_94374949 9.391 GCLM
glutamate-cysteine ligase, modifier subunit
chr19_-_14529853 9.380 DDX39A
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
chr1_+_32757702 9.370 HDAC1
histone deacetylase 1
chr12_+_53342654 9.341 NM_199187
KRT18
keratin 18
chr3_+_49711816 9.317 APEH
N-acylaminoacyl-peptide hydrolase
chr19_-_14530129 9.268 DDX39A
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
chr2_+_181845368 9.263 UBE2E3
ubiquitin-conjugating enzyme E2E 3
chr8_-_101734313 9.250 NM_002568
PABPC1
poly(A) binding protein, cytoplasmic 1
chr19_-_14530155 9.158 NM_005804
DDX39A
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
chr6_-_86352982 9.149 NM_001159677
NM_006372
SYNCRIP

synaptotagmin binding, cytoplasmic RNA interacting protein

chr16_-_88878316 9.071 NM_000485
NM_001030018
APRT

adenine phosphoribosyltransferase

chr7_+_26241329 9.069 CBX3
chromobox homolog 3
chr6_+_41754419 9.060 TOMM6
translocase of outer mitochondrial membrane 6 homolog (yeast)
chr17_-_47492215 9.052 PHB
prohibitin
chr11_-_64014140 9.038 PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr12_-_109125254 8.986 CORO1C
coronin, actin binding protein, 1C
chr16_+_29817810 8.972 NM_001042539
NM_002383
MAZ

MYC-associated zinc finger protein (purine-binding transcription factor)

chr3_+_184032849 8.935 NM_182917
EIF4G1
eukaryotic translation initiation factor 4 gamma, 1
chr17_+_76164624 8.925 NM_004710
SYNGR2
synaptogyrin 2
chr15_-_91537724 8.923 NM_003981
NM_199413
NM_199414
PRC1


protein regulator of cytokinesis 1


chr1_-_94374986 8.919 NM_002061
GCLM
glutamate-cysteine ligase, modifier subunit
chr6_-_36515245 8.896 NM_007271
STK38
serine/threonine kinase 38
chr14_-_74959976 8.873 NPC2
Niemann-Pick disease, type C2
chr20_+_62371109 8.846 NM_020062
SLC2A4RG
SLC2A4 regulator
chr9_+_110046333 8.791 NM_001244724
RAD23B
RAD23 homolog B (S. cerevisiae)
chr8_-_101734290 8.791 PABPC1
poly(A) binding protein, cytoplasmic 1
chr2_-_61765345 8.746 XPO1
exportin 1 (CRM1 homolog, yeast)
chr14_-_100841926 8.738 NM_004184
NM_213646
WARS

tryptophanyl-tRNA synthetase

chr3_-_52567708 8.636 NM_001134231
NT5DC2
5'-nucleotidase domain containing 2
chr19_-_47217576 8.625 NM_001079882
PRKD2
protein kinase D2
chr5_-_176900591 8.619 DBN1
drebrin 1
chr2_-_61765394 8.595 NM_003400
XPO1
exportin 1 (CRM1 homolog, yeast)
chr5_+_95998678 8.593 CAST
calpastatin
chr7_+_143058794 8.591 ZYX
zyxin
chr8_-_101963353 8.526 NM_001135700
NM_001135701
YWHAZ

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide

chr1_-_1822501 8.515 GNB1
guanine nucleotide binding protein (G protein), beta polypeptide 1
chr20_+_62371218 8.504 SLC2A4RG
SLC2A4 regulator
chr1_-_43637788 8.485 EBNA1BP2
EBNA1 binding protein 2
chr1_-_23670743 8.446 NM_001102397
NM_001102398
NM_001102399
NM_005826
HNRNPR



heterogeneous nuclear ribonucleoprotein R



chr1_-_153538305 8.386 NM_005978
S100A2
S100 calcium binding protein A2
chr3_-_52567809 8.314 NT5DC2
5'-nucleotidase domain containing 2
chr7_-_65447162 8.301 GUSB
glucuronidase, beta
chr1_+_32757711 8.254 HDAC1
histone deacetylase 1
chr18_+_12948010 8.253 SEH1L
SEH1-like (S. cerevisiae)
chr6_+_34205369 8.169 HMGA1
high mobility group AT-hook 1
chr2_+_85198176 8.164 NM_020122
KCMF1
potassium channel modulatory factor 1
chr14_+_23340955 8.106 NM_014045
LRP10
low density lipoprotein receptor-related protein 10
chr19_+_54695103 8.093 NM_001077446
TSEN34
tRNA splicing endonuclease 34 homolog (S. cerevisiae)
chr7_+_17338182 8.092 NM_001621
AHR
aryl hydrocarbon receptor
chr1_+_87170515 8.090 SH3GLB1
SH3-domain GRB2-like endophilin B1
chr9_+_110045516 8.073 NM_002874
RAD23B
RAD23 homolog B (S. cerevisiae)
chr19_-_50432952 8.061 NM_016553
NUP62
nucleoporin 62kDa
chr3_-_184870727 8.061 NM_001025266
C3orf70
chromosome 3 open reading frame 70
chr3_+_128997713 7.993 NM_001006109
C3orf37
chromosome 3 open reading frame 37
chr1_+_10459084 7.984 NM_002631
PGD
phosphogluconate dehydrogenase
chr6_-_31704304 7.982 CLIC1
chloride intracellular channel 1
chr6_+_30689414 7.905 TUBB
tubulin, beta class I
chr1_-_33282844 7.835 YARS
tyrosyl-tRNA synthetase
chr1_-_1822493 7.799 GNB1
guanine nucleotide binding protein (G protein), beta polypeptide 1
chr11_-_67169252 7.649 PPP1CA
protein phosphatase 1, catalytic subunit, alpha isozyme
chr18_+_29078026 7.642 NM_001943
DSG2
desmoglein 2
chrX_+_64887534 7.642 MSN
moesin
chr19_+_10982244 7.638 NM_199141
CARM1
coactivator-associated arginine methyltransferase 1
chr12_+_56522202 7.632 ESYT1
extended synaptotagmin-like protein 1
chr1_+_44440642 7.608 ATP6V0B
ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
chr6_-_159065739 7.580 NM_006519
DYNLT1
dynein, light chain, Tctex-type 1
chr11_-_64545864 7.552 SF1
splicing factor 1
chr17_-_5342380 7.546 C1QBP
complement component 1, q subcomponent binding protein
chr8_+_26149080 7.507 PPP2R2A
protein phosphatase 2, regulatory subunit B, alpha
chr7_-_65447187 7.452 GUSB
glucuronidase, beta
chr17_-_5342424 7.435 NM_001212
C1QBP
complement component 1, q subcomponent binding protein
chr10_+_70883856 7.426 NM_001035260
NM_004896
VPS26A

vacuolar protein sorting 26 homolog A (S. pombe)

chr18_+_11981421 7.420 NM_014214
IMPA2
inositol(myo)-1(or 4)-monophosphatase 2
chr20_+_32581553 7.343 RALY
RNA binding protein, autoantigenic (hnRNP-associated with lethal yellow homolog (mouse))
chr9_+_110045551 7.333 RAD23B
RAD23 homolog B (S. cerevisiae)
chr12_-_2986095 7.330 FOXM1
forkhead box M1
chr19_+_797452 7.272 PTBP1
polypyrimidine tract binding protein 1
chr3_-_12705626 7.263 NM_002880
RAF1
v-raf-1 murine leukemia viral oncogene homolog 1
chr7_-_55640198 7.258 NM_030796
VOPP1
vesicular, overexpressed in cancer, prosurvival protein 1
chr9_+_140149768 7.235 COBRA1
cofactor of BRCA1
chr1_-_1822432 7.206 GNB1
CDK11B
guanine nucleotide binding protein (G protein), beta polypeptide 1
cyclin-dependent kinase 11B
chr10_-_126849066 7.130 NM_001329
CTBP2
C-terminal binding protein 2
chr16_+_29831755 7.117 MVP
major vault protein
chr19_+_16187306 7.104 TPM4
tropomyosin 4
chr16_+_128233 7.084 MPG
N-methylpurine-DNA glycosylase
chr3_+_128997616 7.072 NM_020187
C3orf37
chromosome 3 open reading frame 37
chr10_-_126849010 7.059 CTBP2
C-terminal binding protein 2
chr2_-_61765367 7.039 XPO1
exportin 1 (CRM1 homolog, yeast)
chr7_+_26241281 6.960 NM_016587
CBX3
chromobox homolog 3
chr12_+_64798050 6.908 NM_007235
XPOT
exportin, tRNA (nuclear export receptor for tRNAs)
chr8_-_101734162 6.883 PABPC1
poly(A) binding protein, cytoplasmic 1
chr21_+_34775189 6.883 NM_005534
IFNGR2
interferon gamma receptor 2 (interferon gamma transducer 1)
chr9_+_140149756 6.875 NM_015456
COBRA1
cofactor of BRCA1
chr12_+_104324214 6.839 HSP90B1
heat shock protein 90kDa beta (Grp94), member 1
chr1_-_94375028 6.832 GCLM
glutamate-cysteine ligase, modifier subunit

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.22 2.76e-55 GO:0009987 cellular process
1.38 1.25e-43 GO:0044237 cellular metabolic process
1.32 2.12e-38 GO:0008152 metabolic process
1.35 3.73e-37 GO:0044238 primary metabolic process
1.44 2.06e-34 GO:0044260 cellular macromolecule metabolic process
1.39 5.95e-32 GO:0043170 macromolecule metabolic process
1.26 3.39e-26 GO:0050789 regulation of biological process
1.24 4.12e-25 GO:0065007 biological regulation
1.26 5.39e-24 GO:0050794 regulation of cellular process
1.53 1.90e-23 GO:0044267 cellular protein metabolic process
1.43 4.04e-23 GO:0071840 cellular component organization or biogenesis
1.44 6.07e-23 GO:0016043 cellular component organization
1.47 4.72e-21 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.52 1.18e-20 GO:0048519 negative regulation of biological process
1.47 2.80e-20 GO:0071841 cellular component organization or biogenesis at cellular level
1.36 3.10e-20 GO:0051716 cellular response to stimulus
1.48 7.08e-20 GO:0071842 cellular component organization at cellular level
1.54 7.29e-20 GO:0048523 negative regulation of cellular process
1.41 1.95e-19 GO:0006807 nitrogen compound metabolic process
1.46 2.10e-19 GO:0048518 positive regulation of biological process
1.43 5.01e-19 GO:0019538 protein metabolic process
1.48 2.11e-18 GO:0006950 response to stress
1.48 2.31e-18 GO:0048522 positive regulation of cellular process
1.40 2.18e-17 GO:0034641 cellular nitrogen compound metabolic process
1.59 7.72e-17 GO:0006996 organelle organization
1.37 1.42e-16 GO:0007165 signal transduction
1.65 2.97e-15 GO:0002376 immune system process
1.51 2.20e-14 GO:0006464 protein modification process
2.23 4.37e-14 GO:0044419 interspecies interaction between organisms
1.48 7.55e-14 GO:0043412 macromolecule modification
1.31 8.29e-14 GO:0019222 regulation of metabolic process
1.41 8.47e-14 GO:0009058 biosynthetic process
1.42 8.83e-14 GO:0044249 cellular biosynthetic process
1.22 1.05e-13 GO:0050896 response to stimulus
1.31 5.63e-13 GO:0023052 signaling
1.43 7.11e-13 GO:0090304 nucleic acid metabolic process
1.33 7.33e-13 GO:0060255 regulation of macromolecule metabolic process
1.42 1.48e-12 GO:0042221 response to chemical stimulus
1.77 1.48e-12 GO:0046907 intracellular transport
1.66 1.52e-12 GO:0032268 regulation of cellular protein metabolic process
1.64 1.81e-12 GO:0051246 regulation of protein metabolic process
1.31 1.29e-11 GO:0031323 regulation of cellular metabolic process
1.31 2.50e-11 GO:0080090 regulation of primary metabolic process
1.47 5.09e-11 GO:0009059 macromolecule biosynthetic process
1.55 7.65e-11 GO:0010033 response to organic substance
1.54 8.67e-11 GO:0033036 macromolecule localization
1.54 1.54e-10 GO:0051641 cellular localization
1.46 2.16e-10 GO:0034645 cellular macromolecule biosynthetic process
1.43 2.30e-10 GO:0048583 regulation of response to stimulus
1.55 4.22e-10 GO:0031325 positive regulation of cellular metabolic process
1.53 6.59e-10 GO:0009893 positive regulation of metabolic process
1.55 7.35e-10 GO:0044248 cellular catabolic process
1.59 1.31e-09 GO:0007049 cell cycle
1.55 1.71e-09 GO:0010604 positive regulation of macromolecule metabolic process
1.54 2.27e-09 GO:0044085 cellular component biogenesis
1.48 2.32e-09 GO:0009056 catabolic process
1.65 3.15e-09 GO:0051128 regulation of cellular component organization
1.55 4.61e-09 GO:0051649 establishment of localization in cell
1.75 4.62e-09 GO:0051726 regulation of cell cycle
1.61 6.65e-09 GO:0051704 multi-organism process
1.64 6.67e-09 GO:0033554 cellular response to stress
1.55 1.07e-08 GO:0022607 cellular component assembly
1.57 1.14e-08 GO:0009892 negative regulation of metabolic process
1.46 1.88e-08 GO:0009966 regulation of signal transduction
1.40 2.39e-08 GO:0010467 gene expression
1.59 2.78e-08 GO:0010605 negative regulation of macromolecule metabolic process
1.54 3.05e-08 GO:0008104 protein localization
1.59 3.31e-08 GO:0031324 negative regulation of cellular metabolic process
1.74 4.06e-08 GO:0071822 protein complex subunit organization
1.73 6.28e-08 GO:0042060 wound healing
1.55 1.01e-07 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.52 1.14e-07 GO:0010941 regulation of cell death
1.53 1.28e-07 GO:0043067 regulation of programmed cell death
1.25 1.42e-07 GO:0032502 developmental process
1.52 1.70e-07 GO:0042981 regulation of apoptosis
1.67 3.17e-07 GO:0007167 enzyme linked receptor protein signaling pathway
1.74 4.01e-07 GO:0044265 cellular macromolecule catabolic process
1.61 4.27e-07 GO:0016192 vesicle-mediated transport
1.64 4.68e-07 GO:0002682 regulation of immune system process
1.68 5.05e-07 GO:0009057 macromolecule catabolic process
1.58 5.40e-07 GO:0022402 cell cycle process
1.38 5.81e-07 GO:0016070 RNA metabolic process
1.70 6.12e-07 GO:0000278 mitotic cell cycle
2.02 1.02e-06 GO:0010608 posttranscriptional regulation of gene expression
1.74 1.26e-06 GO:0006753 nucleoside phosphate metabolic process
1.74 1.26e-06 GO:0009117 nucleotide metabolic process
1.39 1.40e-06 GO:0023051 regulation of signaling
1.75 1.43e-06 GO:0007010 cytoskeleton organization
1.74 1.66e-06 GO:0070271 protein complex biogenesis
1.33 1.67e-06 GO:0065008 regulation of biological quality
1.56 1.70e-06 GO:0043933 macromolecular complex subunit organization
1.74 1.92e-06 GO:0007596 blood coagulation
1.74 1.92e-06 GO:0050817 coagulation
1.53 2.54e-06 GO:0009611 response to wounding
1.56 2.75e-06 GO:0031399 regulation of protein modification process
1.73 2.98e-06 GO:0007599 hemostasis
1.29 3.97e-06 GO:0010468 regulation of gene expression
1.58 4.54e-06 GO:0071844 cellular component assembly at cellular level
1.72 4.56e-06 GO:0006461 protein complex assembly
1.67 4.84e-06 GO:0050878 regulation of body fluid levels
1.80 5.29e-06 GO:0051247 positive regulation of protein metabolic process
1.67 6.45e-06 GO:0055086 nucleobase, nucleoside and nucleotide metabolic process
1.75 6.86e-06 GO:0060548 negative regulation of cell death
1.56 7.99e-06 GO:0006955 immune response
1.48 1.12e-05 GO:0006793 phosphorus metabolic process
1.48 1.12e-05 GO:0006796 phosphate metabolic process
1.25 1.21e-05 GO:0048856 anatomical structure development
1.49 1.26e-05 GO:0070887 cellular response to chemical stimulus
1.79 1.69e-05 GO:0032270 positive regulation of cellular protein metabolic process
1.51 2.05e-05 GO:0045184 establishment of protein localization
1.99 2.14e-05 GO:0030036 actin cytoskeleton organization
1.37 2.46e-05 GO:0009653 anatomical structure morphogenesis
1.50 2.88e-05 GO:0008219 cell death
1.47 3.04e-05 GO:0042127 regulation of cell proliferation
1.49 4.28e-05 GO:0016265 death
1.50 4.38e-05 GO:0015031 protein transport
1.83 4.69e-05 GO:0009259 ribonucleotide metabolic process
1.37 4.90e-05 GO:0065009 regulation of molecular function
1.44 5.53e-05 GO:0010646 regulation of cell communication
1.28 6.66e-05 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.56 6.74e-05 GO:0022403 cell cycle phase
1.33 6.91e-05 GO:0007166 cell surface receptor linked signaling pathway
2.19 7.63e-05 GO:0022415 viral reproductive process
1.22 7.82e-05 GO:0051179 localization
1.38 8.50e-05 GO:0035556 intracellular signal transduction
2.12 8.61e-05 GO:0051169 nuclear transport
1.22 8.69e-05 GO:0007275 multicellular organismal development
1.70 8.92e-05 GO:0043069 negative regulation of programmed cell death
1.69 1.01e-04 GO:0008283 cell proliferation
1.70 1.03e-04 GO:0043066 negative regulation of apoptosis
1.70 1.03e-04 GO:0072521 purine-containing compound metabolic process
1.57 1.08e-04 GO:0071310 cellular response to organic substance
1.86 1.11e-04 GO:0030029 actin filament-based process
1.49 1.29e-04 GO:0031328 positive regulation of cellular biosynthetic process
1.50 1.30e-04 GO:0048584 positive regulation of response to stimulus
1.73 1.36e-04 GO:0006163 purine nucleotide metabolic process
2.10 1.49e-04 GO:0006913 nucleocytoplasmic transport
1.57 1.56e-04 GO:0051172 negative regulation of nitrogen compound metabolic process
1.32 1.72e-04 GO:0044281 small molecule metabolic process
1.80 1.81e-04 GO:0009150 purine ribonucleotide metabolic process
1.76 2.01e-04 GO:0051301 cell division
1.58 2.02e-04 GO:0006259 DNA metabolic process
1.52 2.02e-04 GO:0012501 programmed cell death
2.21 2.17e-04 GO:0034330 cell junction organization
1.48 2.24e-04 GO:0044093 positive regulation of molecular function
1.53 2.27e-04 GO:0019220 regulation of phosphate metabolic process
1.53 2.27e-04 GO:0051174 regulation of phosphorus metabolic process
1.82 2.32e-04 GO:0009141 nucleoside triphosphate metabolic process
1.57 2.32e-04 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.49 2.98e-04 GO:0051173 positive regulation of nitrogen compound metabolic process
1.61 3.13e-04 GO:0070727 cellular macromolecule localization
1.69 3.15e-04 GO:0016032 viral reproduction
1.62 3.20e-04 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.26 3.26e-04 GO:0010556 regulation of macromolecule biosynthetic process
1.24 3.55e-04 GO:0051171 regulation of nitrogen compound metabolic process
1.96 3.60e-04 GO:0045786 negative regulation of cell cycle
1.73 3.66e-04 GO:0016568 chromatin modification
1.94 3.86e-04 GO:0048011 nerve growth factor receptor signaling pathway
1.65 3.88e-04 GO:0050776 regulation of immune response
1.77 3.97e-04 GO:0033043 regulation of organelle organization
1.77 3.97e-04 GO:0051098 regulation of binding
1.61 4.08e-04 GO:0034613 cellular protein localization
1.75 4.16e-04 GO:0018193 peptidyl-amino acid modification
1.46 4.40e-04 GO:0009891 positive regulation of biosynthetic process
1.24 4.69e-04 GO:0031326 regulation of cellular biosynthetic process
2.24 4.76e-04 GO:0034329 cell junction assembly
2.02 4.85e-04 GO:0022411 cellular component disassembly
2.02 4.85e-04 GO:0071845 cellular component disassembly at cellular level
1.79 5.04e-04 GO:0008380 RNA splicing
1.24 5.45e-04 GO:0009889 regulation of biosynthetic process
1.80 5.65e-04 GO:0009199 ribonucleoside triphosphate metabolic process
1.50 6.45e-04 GO:0006915 apoptosis
1.54 7.16e-04 GO:0051276 chromosome organization
1.74 7.33e-04 GO:0070647 protein modification by small protein conjugation or removal
1.58 7.43e-04 GO:0051253 negative regulation of RNA metabolic process
1.51 7.52e-04 GO:0009890 negative regulation of biosynthetic process
1.79 7.76e-04 GO:0009144 purine nucleoside triphosphate metabolic process
1.49 8.12e-04 GO:0010557 positive regulation of macromolecule biosynthetic process
2.16 8.51e-04 GO:0051052 regulation of DNA metabolic process
1.26 9.28e-04 GO:0051252 regulation of RNA metabolic process
1.51 9.68e-04 GO:0042325 regulation of phosphorylation
1.72 9.89e-04 GO:0010564 regulation of cell cycle process
1.51 1.03e-03 GO:0031327 negative regulation of cellular biosynthetic process
1.79 1.04e-03 GO:0009205 purine ribonucleoside triphosphate metabolic process
2.21 1.09e-03 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB cascade
2.22 1.17e-03 GO:0006403 RNA localization
2.63 1.20e-03 GO:0007173 epidermal growth factor receptor signaling pathway
1.51 1.24e-03 GO:0010558 negative regulation of macromolecule biosynthetic process
2.01 1.25e-03 GO:0002757 immune response-activating signal transduction
2.24 1.25e-03 GO:0050657 nucleic acid transport
2.24 1.25e-03 GO:0050658 RNA transport
2.24 1.25e-03 GO:0051236 establishment of RNA localization
1.53 1.35e-03 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.41 1.36e-03 GO:0032774 RNA biosynthetic process
1.49 1.36e-03 GO:0065003 macromolecular complex assembly
1.77 1.44e-03 GO:0051329 interphase of mitotic cell cycle
1.76 1.46e-03 GO:0051325 interphase
1.47 1.51e-03 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.44 1.61e-03 GO:0016310 phosphorylation
2.16 1.62e-03 GO:0019058 viral infectious cycle
1.62 1.63e-03 GO:0002684 positive regulation of immune system process
1.53 1.72e-03 GO:0010629 negative regulation of gene expression
2.05 1.94e-03 GO:0043623 cellular protein complex assembly
1.22 2.00e-03 GO:0048731 system development
1.58 2.11e-03 GO:0009967 positive regulation of signal transduction
1.23 2.17e-03 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.50 2.18e-03 GO:0046483 heterocycle metabolic process
1.71 2.31e-03 GO:0051603 proteolysis involved in cellular protein catabolic process
1.97 2.78e-03 GO:0002764 immune response-regulating signaling pathway
2.06 2.97e-03 GO:0050900 leukocyte migration
1.97 3.13e-03 GO:0016569 covalent chromatin modification
1.55 3.27e-03 GO:0023056 positive regulation of signaling
1.67 3.39e-03 GO:0030163 protein catabolic process
1.81 3.56e-03 GO:0051248 negative regulation of protein metabolic process
1.56 3.70e-03 GO:0043065 positive regulation of apoptosis
1.78 3.79e-03 GO:0007346 regulation of mitotic cell cycle
1.60 3.86e-03 GO:0016044 cellular membrane organization
1.48 3.89e-03 GO:0009719 response to endogenous stimulus
1.35 3.90e-03 GO:0050790 regulation of catalytic activity
1.55 4.19e-03 GO:0010647 positive regulation of cell communication
1.77 4.42e-03 GO:0010740 positive regulation of intracellular protein kinase cascade
2.17 4.64e-03 GO:0043388 positive regulation of DNA binding
1.59 4.87e-03 GO:0061024 membrane organization
2.08 5.03e-03 GO:0015931 nucleobase, nucleoside, nucleotide and nucleic acid transport
1.56 5.05e-03 GO:0034621 cellular macromolecular complex subunit organization
1.55 5.14e-03 GO:0043068 positive regulation of programmed cell death
1.49 5.15e-03 GO:0001932 regulation of protein phosphorylation
1.68 5.27e-03 GO:0044257 cellular protein catabolic process
1.98 5.42e-03 GO:0030155 regulation of cell adhesion
2.67 5.61e-03 GO:0060333 interferon-gamma-mediated signaling pathway
1.84 5.76e-03 GO:0009261 ribonucleotide catabolic process
1.60 5.90e-03 GO:0032583 regulation of gene-specific transcription
1.69 6.14e-03 GO:0019941 modification-dependent protein catabolic process
1.71 6.18e-03 GO:0031401 positive regulation of protein modification process
1.53 6.21e-03 GO:0016071 mRNA metabolic process
2.06 6.25e-03 GO:0043122 regulation of I-kappaB kinase/NF-kappaB cascade
2.06 6.25e-03 GO:0051099 positive regulation of binding
2.17 6.41e-03 GO:0043254 regulation of protein complex assembly
3.01 6.75e-03 GO:0045767 regulation of anti-apoptosis
1.83 6.81e-03 GO:0002253 activation of immune response
1.54 6.87e-03 GO:0010942 positive regulation of cell death
1.63 6.99e-03 GO:0010627 regulation of intracellular protein kinase cascade
1.80 7.38e-03 GO:0032269 negative regulation of cellular protein metabolic process
1.53 7.92e-03 GO:0045892 negative regulation of transcription, DNA-dependent
1.68 8.06e-03 GO:0043632 modification-dependent macromolecule catabolic process
2.57 8.25e-03 GO:0044403 symbiosis, encompassing mutualism through parasitism
1.52 8.75e-03 GO:0006928 cellular component movement
1.97 9.03e-03 GO:0006417 regulation of translation
1.83 9.18e-03 GO:0009154 purine ribonucleotide catabolic process
1.71 9.43e-03 GO:0051130 positive regulation of cellular component organization
2.03 9.55e-03 GO:0007568 aging
1.53 9.75e-03 GO:0006974 response to DNA damage stimulus
1.53 9.75e-03 GO:0080134 regulation of response to stress
1.93 1.04e-02 GO:0016570 histone modification
1.83 1.05e-02 GO:0009203 ribonucleoside triphosphate catabolic process
1.83 1.05e-02 GO:0009207 purine ribonucleoside triphosphate catabolic process
1.48 1.12e-02 GO:0009725 response to hormone stimulus
1.46 1.12e-02 GO:0045595 regulation of cell differentiation
1.59 1.14e-02 GO:0008285 negative regulation of cell proliferation
1.61 1.14e-02 GO:0006886 intracellular protein transport
1.46 1.23e-02 GO:0051254 positive regulation of RNA metabolic process
1.82 1.24e-02 GO:0009146 purine nucleoside triphosphate catabolic process
1.72 1.25e-02 GO:0032446 protein modification by small protein conjugation
1.59 1.38e-02 GO:0009968 negative regulation of signal transduction
1.68 1.42e-02 GO:0006412 translation
1.86 1.51e-02 GO:0044087 regulation of cellular component biogenesis
1.98 1.57e-02 GO:0046039 GTP metabolic process
1.43 1.66e-02 GO:0006468 protein phosphorylation
1.44 1.68e-02 GO:0043085 positive regulation of catalytic activity
1.36 1.72e-02 GO:0009605 response to external stimulus
1.54 1.81e-02 GO:0006325 chromatin organization
3.42 1.84e-02 GO:0043488 regulation of mRNA stability
1.74 1.89e-02 GO:0009166 nucleotide catabolic process
1.56 1.89e-02 GO:0023057 negative regulation of signaling
2.34 1.97e-02 GO:0051168 nuclear export
1.80 2.01e-02 GO:0009143 nucleoside triphosphate catabolic process
1.66 2.10e-02 GO:0006511 ubiquitin-dependent protein catabolic process
2.14 2.14e-02 GO:0016197 endosome transport
1.71 2.53e-02 GO:0051101 regulation of DNA binding
1.46 2.59e-02 GO:0045893 positive regulation of transcription, DNA-dependent
2.72 2.61e-02 GO:0051701 interaction with host
2.21 2.75e-02 GO:0051235 maintenance of location
1.75 2.86e-02 GO:0006195 purine nucleotide catabolic process
1.83 2.86e-02 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
1.83 2.86e-02 GO:0000398 nuclear mRNA splicing, via spliceosome
1.68 2.86e-02 GO:0042493 response to drug
1.82 2.95e-02 GO:0000375 RNA splicing, via transesterification reactions
1.92 2.98e-02 GO:0031400 negative regulation of protein modification process
2.09 3.07e-02 GO:0007265 Ras protein signal transduction
1.19 3.08e-02 GO:0051234 establishment of localization
3.31 3.16e-02 GO:0043487 regulation of RNA stability
1.37 3.19e-02 GO:0050793 regulation of developmental process
2.16 3.23e-02 GO:0002429 immune response-activating cell surface receptor signaling pathway
1.73 3.33e-02 GO:0072523 purine-containing compound catabolic process
1.67 3.74e-02 GO:0002520 immune system development
1.54 3.74e-02 GO:0010648 negative regulation of cell communication
2.21 3.81e-02 GO:0050851 antigen receptor-mediated signaling pathway
1.87 3.95e-02 GO:0043687 post-translational protein modification
1.23 3.98e-02 GO:0048869 cellular developmental process
1.37 3.98e-02 GO:0006351 transcription, DNA-dependent
2.43 3.99e-02 GO:0071346 cellular response to interferon-gamma
2.54 4.02e-02 GO:0009411 response to UV
2.90 4.06e-02 GO:0007569 cell aging
1.19 4.52e-02 GO:0006810 transport
1.66 4.91e-02 GO:0050778 positive regulation of immune response

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.33 3.47e-58 GO:0005737 cytoplasm
1.22 9.10e-58 GO:0044424 intracellular part
1.20 5.53e-51 GO:0005622 intracellular
1.23 1.67e-42 GO:0043229 intracellular organelle
1.23 3.83e-42 GO:0043226 organelle
1.37 4.42e-40 GO:0044444 cytoplasmic part
1.39 6.41e-40 GO:0044446 intracellular organelle part
1.38 1.48e-39 GO:0044422 organelle part
1.25 1.28e-37 GO:0043231 intracellular membrane-bounded organelle
1.25 1.57e-37 GO:0043227 membrane-bounded organelle
1.70 5.23e-37 GO:0044428 nuclear part
1.71 9.58e-36 GO:0005829 cytosol
1.61 5.20e-31 GO:0031974 membrane-enclosed lumen
1.62 7.11e-31 GO:0043233 organelle lumen
1.62 6.41e-30 GO:0070013 intracellular organelle lumen
1.68 1.32e-28 GO:0031981 nuclear lumen
1.45 1.67e-28 GO:0032991 macromolecular complex
1.30 4.97e-24 GO:0005634 nucleus
1.45 9.99e-23 GO:0043234 protein complex
1.72 3.25e-22 GO:0005654 nucleoplasm
1.40 6.24e-16 GO:0043228 non-membrane-bounded organelle
1.40 6.24e-16 GO:0043232 intracellular non-membrane-bounded organelle
1.06 2.63e-11 GO:0044464 cell part
1.06 2.81e-11 GO:0005623 cell
1.64 1.15e-08 GO:0031967 organelle envelope
1.63 1.42e-08 GO:0031975 envelope
2.14 1.55e-08 GO:0005635 nuclear envelope
1.73 1.26e-07 GO:0005730 nucleolus
1.94 3.43e-07 GO:0015629 actin cytoskeleton
1.56 1.58e-06 GO:0044451 nucleoplasm part
1.30 2.56e-06 GO:0031090 organelle membrane
1.36 2.65e-06 GO:0012505 endomembrane system
1.65 4.48e-06 GO:0030529 ribonucleoprotein complex
2.13 2.00e-05 GO:0070161 anchoring junction
1.33 7.70e-05 GO:0005856 cytoskeleton
2.16 9.44e-05 GO:0031965 nuclear membrane
2.41 1.03e-04 GO:0005925 focal adhesion
2.33 1.27e-04 GO:0030055 cell-substrate junction
2.35 1.32e-04 GO:0005924 cell-substrate adherens junction
2.09 2.14e-04 GO:0005912 adherens junction
4.41 6.67e-04 GO:0030530 heterogeneous nuclear ribonucleoprotein complex
1.38 6.94e-04 GO:0005794 Golgi apparatus
1.36 8.76e-04 GO:0005783 endoplasmic reticulum
1.63 1.89e-03 GO:0048471 perinuclear region of cytoplasm
1.88 2.12e-03 GO:0031252 cell leading edge
1.49 2.39e-03 GO:0005694 chromosome
1.52 4.52e-03 GO:0044427 chromosomal part
1.75 5.78e-03 GO:0016604 nuclear body
2.23 6.29e-03 GO:0042470 melanosome
2.23 6.29e-03 GO:0048770 pigment granule
1.32 6.49e-03 GO:0000267 cell fraction
2.40 8.21e-03 GO:0005643 nuclear pore
1.59 1.05e-02 GO:0005625 soluble fraction
2.23 1.21e-02 GO:0046930 pore complex
1.36 2.51e-02 GO:0044432 endoplasmic reticulum part
1.83 3.75e-02 GO:0045121 membrane raft
1.37 4.48e-02 GO:0015630 microtubule cytoskeleton
1.34 4.88e-02 GO:0031982 vesicle
1.74 4.89e-02 GO:0005819 spindle

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.43 2.18e-79 GO:0005515 protein binding
1.17 2.54e-40 GO:0005488 binding
1.66 1.20e-09 GO:0019899 enzyme binding
1.34 4.61e-09 GO:0000166 nucleotide binding
1.63 8.61e-09 GO:0042802 identical protein binding
1.56 1.51e-07 GO:0003723 RNA binding
1.31 1.03e-05 GO:0017076 purine nucleotide binding
1.31 1.70e-05 GO:0035639 purine ribonucleoside triphosphate binding
1.31 2.44e-05 GO:0032553 ribonucleotide binding
1.31 2.44e-05 GO:0032555 purine ribonucleotide binding
1.55 2.54e-05 GO:0046983 protein dimerization activity
1.67 2.99e-05 GO:0019904 protein domain specific binding
2.03 6.75e-05 GO:0003682 chromatin binding
1.15 9.13e-05 GO:0003824 catalytic activity
1.67 3.29e-04 GO:0000988 protein binding transcription factor activity
1.67 3.29e-04 GO:0000989 transcription factor binding transcription factor activity
1.89 5.35e-04 GO:0003924 GTPase activity
1.65 5.62e-04 GO:0003712 transcription cofactor activity
1.30 6.89e-04 GO:0030554 adenyl nucleotide binding
2.05 1.07e-03 GO:0003714 transcription corepressor activity
2.50 1.61e-03 GO:0042393 histone binding
1.71 1.62e-03 GO:0008134 transcription factor binding
1.29 1.76e-03 GO:0032559 adenyl ribonucleotide binding
1.29 1.92e-03 GO:0005524 ATP binding
1.48 1.99e-03 GO:0005198 structural molecule activity
1.57 2.54e-03 GO:0042803 protein homodimerization activity
2.01 2.76e-03 GO:0008022 protein C-terminus binding
1.77 3.62e-03 GO:0019900 kinase binding
1.36 1.11e-02 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.40 1.25e-02 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.38 1.29e-02 GO:0016301 kinase activity
1.77 1.71e-02 GO:0019901 protein kinase binding
1.84 1.99e-02 GO:0000287 magnesium ion binding
2.26 2.22e-02 GO:0031625 ubiquitin protein ligase binding
1.59 2.74e-02 GO:0016563 transcription activator activity
2.81 3.15e-02 GO:0003823 antigen binding
1.24 3.29e-02 GO:0016740 transferase activity
1.44 3.63e-02 GO:0008092 cytoskeletal protein binding
2.65 4.93e-02 GO:0046332 SMAD binding