Motif ID: bHLH_family.p2

Z-value: 3.186


Transcription factors associated with bHLH_family.p2:

Gene SymbolEntrez IDGene Name
ARNTL 406 aryl hydrocarbon receptor nuclear translocator-like
ARNTL2 56938 aryl hydrocarbon receptor nuclear translocator-like 2
CLOCK 9575 clock homolog (mouse)
HES6 55502 hairy and enhancer of split 6 (Drosophila)
HEY1 23462 hairy/enhancer-of-split related with YRPW motif 1
HEY2 23493 hairy/enhancer-of-split related with YRPW motif 2
HEYL 26508 hairy/enhancer-of-split related with YRPW motif-like
ID1 3397 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
MITF 4286 microphthalmia-associated transcription factor
MLXIPL 51085 MLX interacting protein-like
MNT 4335 MAX binding protein
MXD3 83463 MAX dimerization protein 3
MXD4 10608 MAX dimerization protein 4
MXI1 4601 MAX interactor 1
NPAS2 4862 neuronal PAS domain protein 2
OLIG1 116448 oligodendrocyte transcription factor 1
OLIG2 10215 oligodendrocyte lineage transcription factor 2
TFE3 7030 transcription factor binding to IGHM enhancer 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HEYLchr1_-_40105341,
chr1_-_40098639
-0.686.5e-31Click!
HEY2chr6_+_126070724,
chr6_+_126070813
-0.659.8e-28Click!
OLIG2chr21_+_34398210-0.614.8e-24Click!
MLXIPLchr7_-_73038814-0.605.1e-23Click!
ARNTLchr11_+_13299260-0.547.8e-18Click!
MXD4chr4_-_2263808-0.492.4e-14Click!
ID1chr20_+_301930830.452.7e-12Click!
MXI1chr10_+_111967302-0.384.3e-09Click!
HEY1chr8_-_80679897-0.366.8e-08Click!
ARNTL2chr12_+_274857670.357.3e-08Click!
NPAS2chr2_+_101436491-0.321.7e-06Click!
TFE3chrX_-_48900932-0.244.6e-04Click!
MXD3chr5_-_176738831-0.161.5e-02Click!
CLOCKchr4_-_56412968-0.144.5e-02Click!
MITFchr3_+_698129610.111.1e-01Click!
MNTchr17_-_23042170.063.5e-01Click!


Activity profile for motif bHLH_family.p2.

activity profile for motif bHLH_family.p2


Sorted Z-values histogram for motif bHLH_family.p2

Sorted Z-values for motif bHLH_family.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of bHLH_family.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_-_58146108 283.386 CDK4
cyclin-dependent kinase 4
chr12_-_58146110 280.453 CDK4
cyclin-dependent kinase 4
chr12_-_58146025 280.326 CDK4
cyclin-dependent kinase 4
chr12_-_58146118 264.246 NM_000075
CDK4
cyclin-dependent kinase 4
chr2_+_216176818 89.213 ATIC
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
chr2_+_216176808 86.379 ATIC
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
chr17_+_76164624 83.300 NM_004710
SYNGR2
synaptogyrin 2
chr8_+_97274106 80.650 PTDSS1
phosphatidylserine synthase 1
chr2_+_216176678 76.734 NM_004044
ATIC
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
chr2_-_10588451 74.329 NM_002539
ODC1
ornithine decarboxylase 1
chr4_-_100871482 71.323 NM_002106
H2AFZ
H2A histone family, member Z
chr20_+_44519924 71.206 CTSA
cathepsin A
chr20_+_44519965 69.443 CTSA
cathepsin A
chr11_-_64014381 67.786 PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr14_+_20923705 66.832 APEX1
APEX nuclease (multifunctional DNA repair enzyme) 1
chr8_+_55047780 64.741 NM_014175
MRPL15
mitochondrial ribosomal protein L15
chr20_+_44519590 63.488 NM_000308
NM_001127695
NM_001167594
CTSA


cathepsin A


chr11_-_64014264 62.374 PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr14_+_20923364 61.603 APEX1
APEX nuclease (multifunctional DNA repair enzyme) 1
chr11_+_61560352 58.401 FEN1
flap structure-specific endonuclease 1
chr2_-_198364560 58.026 HSPD1
heat shock 60kDa protein 1 (chaperonin)
chr14_+_20923341 57.854 APEX1
APEX nuclease (multifunctional DNA repair enzyme) 1
chr20_+_44520203 57.251 CTSA
cathepsin A
chr2_-_10588273 57.102 ODC1
ornithine decarboxylase 1
chr3_+_52719935 56.826 NM_014366
NM_206825
NM_206826
GNL3


guanine nucleotide binding protein-like 3 (nucleolar)


chr1_-_26233367 55.789 NM_203399
STMN1
stathmin 1
chr8_+_98656428 55.632 MTDH
metadherin
chr20_+_44520021 55.465 CTSA
cathepsin A
chr5_+_34656482 55.197 RAI14
retinoic acid induced 14
chr19_+_50180492 54.945 PRMT1
protein arginine methyltransferase 1
chr14_+_20923289 54.389 NM_001244249
NM_001641
NM_080648
NM_080649
APEX1



APEX nuclease (multifunctional DNA repair enzyme) 1



chr8_+_98656329 53.063 NM_178812
MTDH
metadherin
chr19_+_50180408 51.657 NM_001207042
NM_001536
NM_198318
PRMT1


protein arginine methyltransferase 1


chr19_+_10765106 51.572 ILF3
interleukin enhancer binding factor 3, 90kDa
chr7_-_99698993 51.156 MCM7
minichromosome maintenance complex component 7
chr11_-_64014140 51.097 PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr1_-_155231941 50.905 SCAMP3
secretory carrier membrane protein 3
chr7_-_99699030 50.514 MCM7
minichromosome maintenance complex component 7
chr1_-_78148326 50.229 NM_015534
ZZZ3
zinc finger, ZZ-type containing 3
chr4_-_100871431 49.853 H2AFZ
H2A histone family, member Z
chr6_-_43197178 49.727 NM_006443
NM_199184
C6orf108

chromosome 6 open reading frame 108

chr8_+_98656494 47.553 MTDH
metadherin
chr7_+_100464949 47.159 NM_003302
TRIP6
thyroid hormone receptor interactor 6
chr19_-_42806928 46.987 NM_001145939
NM_001145940
PAFAH1B3

platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)

chr1_-_159895258 46.704 TAGLN2
transgelin 2
chr5_-_61699598 46.572 DIMT1
DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae)
chr17_+_49230938 45.916 NME1
NME1-NME2
non-metastatic cells 1, protein (NM23A) expressed in
NME1-NME2 readthrough
chr4_+_57301898 45.347 NM_006452
PAICS
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
chr8_+_22224997 45.132 NM_001135153
SLC39A14
solute carrier family 39 (zinc transporter), member 14
chr11_+_61560108 44.637 NM_004111
FEN1
flap structure-specific endonuclease 1
chr7_-_99698916 44.219 MCM7
minichromosome maintenance complex component 7
chr8_+_98788014 44.051 LAPTM4B
lysosomal protein transmembrane 4 beta
chr4_+_140222668 44.001 NM_057175
NAA15
N(alpha)-acetyltransferase 15, NatA auxiliary subunit
chr1_-_155232091 43.890 NM_005698
NM_052837
SCAMP3

secretory carrier membrane protein 3

chr1_+_44440623 43.584 ATP6V0B
ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
chr12_-_49318663 43.530 NM_001143781
FKBP11
FK506 binding protein 11, 19 kDa
chr1_-_26232890 43.473 NM_001145454
NM_005563
STMN1

stathmin 1

chr19_+_41256758 43.348 NM_004596
SNRPA
small nuclear ribonucleoprotein polypeptide A
chr17_+_49230954 43.184 NME1
NME1-NME2
non-metastatic cells 1, protein (NM23A) expressed in
NME1-NME2 readthrough
chr2_+_113403433 43.059 NM_005415
SLC20A1
solute carrier family 20 (phosphate transporter), member 1
chr11_-_64014407 42.807 NM_138689
PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr17_+_49230929 42.764 NME1
non-metastatic cells 1, protein (NM23A) expressed in
chr1_-_159895279 42.313 NM_003564
TAGLN2
transgelin 2
chr8_+_22224758 41.764 NM_001128431
NM_001135154
NM_015359
SLC39A14


solute carrier family 39 (zinc transporter), member 14


chr11_+_61560401 40.579 FEN1
flap structure-specific endonuclease 1
chr5_+_34656595 40.552 NM_001145520
RAI14
retinoic acid induced 14
chrX_+_118602391 40.508 SLC25A5
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
chr1_-_155231994 40.110 SCAMP3
secretory carrier membrane protein 3
chr1_+_44440595 39.952 NM_001039457
NM_004047
ATP6V0B

ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b

chr3_+_49059046 39.354 NM_199069
NM_199070
NDUFAF3

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 3

chr16_-_103557 39.296 NM_016310
POLR3K
polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
chr13_+_76123885 39.292 NM_006002
UCHL3
ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
chr1_-_8938745 39.205 ENO1
enolase 1, (alpha)
chr12_+_6833425 38.432 NM_001164093
COPS7A
COP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis)
chr11_+_69455837 38.136 NM_053056
CCND1
cyclin D1
chr1_+_182992694 38.116


chr12_+_53645369 38.096 NM_001170790
MFSD5
major facilitator superfamily domain containing 5
chr17_+_49230896 37.570 NM_000269
NM_198175
NM_001018136
NME1

NME1-NME2
non-metastatic cells 1, protein (NM23A) expressed in

NME1-NME2 readthrough
chr16_+_103009 37.306 SNRNP25
small nuclear ribonucleoprotein 25kDa (U11/U12)
chr1_-_78149093 37.288 ZZZ3
zinc finger, ZZ-type containing 3
chr6_-_33386064 37.212 NM_001014433
NM_001014837
NM_001014838
NM_001014840
NM_015921
CUTA




cutA divalent cation tolerance homolog (E. coli)




chr6_+_44191504 37.111 SLC29A1
solute carrier family 29 (nucleoside transporters), member 1
chr16_+_23690234 37.065 PLK1
polo-like kinase 1
chr11_+_118958696 37.012 NM_001024382
HMBS
hydroxymethylbilane synthase
chr9_-_34048887 37.005 NM_018449
UBAP2
ubiquitin associated protein 2
chr3_+_49059490 36.736 NDUFAF3
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 3
chr16_+_23690160 36.732 PLK1
polo-like kinase 1
chr5_+_34656367 36.082 NM_001145522
NM_015577
RAI14

retinoic acid induced 14

chr1_-_8938727 36.055 ENO1
enolase 1, (alpha)
chr6_+_44191276 35.930 NM_001078175
NM_001078176
NM_001078177
SLC29A1


solute carrier family 29 (nucleoside transporters), member 1


chr2_-_198364522 35.672 HSPD1
heat shock 60kDa protein 1 (chaperonin)
chr20_+_48552902 35.626 NM_018683
RNF114
ring finger protein 114
chr4_-_100871418 35.506 H2AFZ
H2A histone family, member Z
chr17_-_5342424 35.452 NM_001212
C1QBP
complement component 1, q subcomponent binding protein
chr1_+_44440673 35.248 ATP6V0B
ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
chrX_+_131157635 35.087 NM_001042452
MST4
serine/threonine protein kinase MST4
chr9_+_131452253 34.844 NM_001248001
SET
SET nuclear oncogene
chr2_-_198364623 34.681 NM_002156
HSPD1
heat shock 60kDa protein 1 (chaperonin)
chr6_-_97345747 34.650 NDUFAF4
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 4
chrX_+_118602362 34.479 NM_001152
SLC25A5
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
chr1_-_40042072 34.313 PABPC4
poly(A) binding protein, cytoplasmic 4 (inducible form)
chr6_-_17706617 34.142 NM_005124
NUP153
nucleoporin 153kDa
chr1_+_44440642 34.032 ATP6V0B
ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
chr5_-_150466696 33.949 NM_001252391
NM_001252392
TNIP1

TNFAIP3 interacting protein 1

chr6_-_33385662 33.722 CUTA
cutA divalent cation tolerance homolog (E. coli)
chr4_-_47465646 33.560 NM_017845
COMMD8
COMM domain containing 8
chr1_-_8938691 33.508 ENO1
enolase 1, (alpha)
chr19_+_47634044 33.507 NM_001145713
NM_001145714
NM_005500
SAE1


SUMO1 activating enzyme subunit 1


chrX_+_23685613 33.292 PRDX4
peroxiredoxin 4
chr11_-_118972529 33.155 DPAGT1
dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase)
chr3_-_49066760 33.148 IMPDH2
IMP (inosine 5'-monophosphate) dehydrogenase 2
chr16_+_103827 33.103 NM_024571
SNRNP25
small nuclear ribonucleoprotein 25kDa (U11/U12)
chr16_+_23690191 33.086 NM_005030
PLK1
polo-like kinase 1
chr7_-_23509972 33.053 NM_006547
IGF2BP3
insulin-like growth factor 2 mRNA binding protein 3
chr11_-_64084980 32.914 NM_016404
TRMT112
tRNA methyltransferase 11-2 homolog (S. cerevisiae)
chr11_-_36310974 32.831 NM_001101653
NM_014186
COMMD9

COMM domain containing 9

chr12_+_49658862 32.631 NM_032704
TUBA1C
tubulin, alpha 1c
chr1_+_43148359 32.583 YBX1
Y box binding protein 1
chr17_+_7476023 32.395 NM_001204510
NM_001416
EIF4A1

eukaryotic translation initiation factor 4A1

chr11_-_118972784 32.141 NM_001382
DPAGT1
dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase)
chr7_-_105162551 32.076 NM_019042
PUS7
pseudouridylate synthase 7 homolog (S. cerevisiae)
chr4_-_99850280 31.990 EIF4E
eukaryotic translation initiation factor 4E
chr16_+_103859 31.897 SNRNP25
small nuclear ribonucleoprotein 25kDa (U11/U12)
chr4_-_47465719 31.863 COMMD8
COMM domain containing 8
chr2_-_61764661 31.860 XPO1
exportin 1 (CRM1 homolog, yeast)
chr16_+_103892 31.811 SNRNP25
small nuclear ribonucleoprotein 25kDa (U11/U12)
chr16_+_23690190 31.671 PLK1
polo-like kinase 1
chr6_-_109703661 31.639 CD164
CD164 molecule, sialomucin
chr17_+_49244082 31.521 NM_001018138
NME2
non-metastatic cells 2, protein (NM23B) expressed in
chrX_+_23685658 31.313 PRDX4
peroxiredoxin 4
chr1_-_26232643 31.307 NM_203401
STMN1
stathmin 1
chr6_-_33385814 31.305


chr19_+_54695103 31.267 NM_001077446
TSEN34
tRNA splicing endonuclease 34 homolog (S. cerevisiae)
chr3_-_50360109 31.243 NM_003773
NM_033158
HYAL2

hyaluronoglucosaminidase 2

chrX_+_23685637 31.241 NM_006406
PRDX4
peroxiredoxin 4
chr15_+_44084517 31.077 NM_001199878
SERF2-C15ORF63
SERF2
SERF2-C15orf63 readthrough
small EDRK-rich factor 2
chr1_-_11120001 31.029 SRM
spermidine synthase
chr16_+_23690212 31.021 PLK1
polo-like kinase 1
chr12_-_123380608 30.983


chr8_+_22224786 30.747 SLC39A14
solute carrier family 39 (zinc transporter), member 14
chr17_-_46688362 30.426 NM_004502
HOXB7
homeobox B7
chr5_+_179126009 30.323 CANX
calnexin
chr12_-_46662779 30.266 SLC38A1
solute carrier family 38, member 1
chr6_-_8102753 30.167 NM_001135650
NM_004280
EEF1E1

eukaryotic translation elongation factor 1 epsilon 1

chr6_-_97345760 30.014 NM_014165
NDUFAF4
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 4
chr1_-_110950241 29.999 HBXIP
hepatitis B virus x interacting protein
chr8_+_97274137 29.880 PTDSS1
phosphatidylserine synthase 1
chr8_+_22436253 29.564 NM_021630
PDLIM2
PDZ and LIM domain 2 (mystique)
chr11_+_18344113 29.557 GTF2H1
general transcription factor IIH, polypeptide 1, 62kDa
chr17_+_49243632 29.333 NM_001198682
NM_002512
NME2

non-metastatic cells 2, protein (NM23B) expressed in

chr11_-_47664014 29.234 NM_014342
MTCH2
mitochondrial carrier 2
chr1_+_166808721 29.151 NM_017542
POGK
pogo transposable element with KRAB domain
chr5_+_110074708 29.030 SLC25A46
solute carrier family 25, member 46
chr2_+_198365012 28.996 HSPE1
heat shock 10kDa protein 1 (chaperonin 10)
chr6_-_28891409 28.965 TRIM27
tripartite motif containing 27
chr1_+_218458646 28.941 RRP15
ribosomal RNA processing 15 homolog (S. cerevisiae)
chr1_+_154193757 28.787 UBAP2L
ubiquitin associated protein 2-like
chr19_-_8386245 28.698 NDUFA7
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa
chr19_+_797390 28.667 NM_002819
NM_031990
NM_031991
NM_175847
PTBP1



polypyrimidine tract binding protein 1



chr12_-_65153189 28.514 NM_002076
GNS
glucosamine (N-acetyl)-6-sulfatase
chr1_-_150669499 28.337 NM_018178
GOLPH3L
golgi phosphoprotein 3-like
chr5_+_110074740 28.170 NM_138773
SLC25A46
solute carrier family 25, member 46
chr8_+_145582208 28.113 NM_001253816
NM_001253815
GPR172A

G protein-coupled receptor 172A

chr4_+_57302448 28.111 PAICS
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
chr10_+_75910908 28.045 NM_001202450
NM_006721
ADK

adenosine kinase

chr12_-_102512277 27.952 NM_024057
NUP37
nucleoporin 37kDa
chr17_+_49243770 27.763 NM_001018139
NME2
non-metastatic cells 2, protein (NM23B) expressed in
chr9_-_34637623 27.640 SIGMAR1
sigma non-opioid intracellular receptor 1
chr14_-_58894217 27.558 NM_012460
TIMM9
translocase of inner mitochondrial membrane 9 homolog (yeast)
chr20_+_48552935 27.522 RNF114
ring finger protein 114
chr22_-_42343079 27.445 NM_001002876
NM_024053
CENPM

centromere protein M

chr9_-_34637752 27.285 NM_005866
NM_147157
SIGMAR1

sigma non-opioid intracellular receptor 1

chr3_+_158519888 27.209 MFSD1
major facilitator superfamily domain containing 1
chr8_-_103667882 27.024 NM_005655
KLF10
Kruppel-like factor 10
chr3_+_184032849 26.927 NM_182917
EIF4G1
eukaryotic translation initiation factor 4 gamma, 1
chr19_+_47634133 26.920 SAE1
SUMO1 activating enzyme subunit 1
chr4_-_157892545 26.836 NM_016205
PDGFC
platelet derived growth factor C
chr3_-_49066813 26.795 IMPDH2
IMP (inosine 5'-monophosphate) dehydrogenase 2
chr3_+_158519877 26.794 MFSD1
major facilitator superfamily domain containing 1
chr12_+_131356557 26.554 NM_006325
RAN
RAN, member RAS oncogene family
chrX_+_131157231 26.517 NM_001042453
NM_016542
MST4

serine/threonine protein kinase MST4

chr3_+_158519714 26.330 NM_001167903
NM_022736
MFSD1

major facilitator superfamily domain containing 1

chr20_+_17550598 26.163 NM_001011546
NM_006870
DSTN

destrin (actin depolymerizing factor)

chr19_+_49458151 26.141 BAX
BCL2-associated X protein
chr1_-_183604850 26.110 ARPC5
actin related protein 2/3 complex, subunit 5, 16kDa
chr2_+_198364720 26.094 NM_001202485
NM_002157
HSPE1-MOB4
HSPE1
HSPE1-MOB4 readthrough
heat shock 10kDa protein 1 (chaperonin 10)
chr19_-_8386273 25.928 NM_005001
NDUFA7
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa
chr17_+_55163077 25.909 NM_001242903
NM_001242902
AKAP1

A kinase (PRKA) anchor protein 1

chr10_-_120840241 25.819 EIF3A
eukaryotic translation initiation factor 3, subunit A
chr1_-_183604885 25.778 NM_005717
ARPC5
actin related protein 2/3 complex, subunit 5, 16kDa
chr2_+_198365113 25.590 HSPE1
heat shock 10kDa protein 1 (chaperonin 10)
chr1_+_214776494 25.531 NM_016343
CENPF
centromere protein F, 350/400kDa (mitosin)
chr8_+_97274158 25.295 NM_014754
PTDSS1
phosphatidylserine synthase 1
chr9_+_117350097 25.257 ATP6V1G1
ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1
chr12_+_53342842 25.219 NM_000224
KRT18
keratin 18
chr16_-_81129882 25.113 NM_004483
GCSH
glycine cleavage system protein H (aminomethyl carrier)
chr15_-_72523713 25.050 NM_001206796
NM_001206797
NM_001206798
NM_002654
NM_182470
NM_182471
PKM2





pyruvate kinase, muscle





chr2_+_29117503 24.996 NM_015131
WDR43
WD repeat domain 43
chr20_+_48552928 24.985 RNF114
ring finger protein 114
chr7_+_16685757 24.963 NM_001159767
NM_014038
BZW2

basic leucine zipper and W2 domains 2


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.25 3.85e-51 GO:0009987 cellular process
1.46 1.71e-48 GO:0044237 cellular metabolic process
1.38 6.40e-41 GO:0008152 metabolic process
1.40 2.65e-36 GO:0044238 primary metabolic process
1.63 1.12e-34 GO:0006807 nitrogen compound metabolic process
1.64 4.99e-34 GO:0034641 cellular nitrogen compound metabolic process
1.50 2.11e-33 GO:0044260 cellular macromolecule metabolic process
1.66 7.04e-31 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.42 1.12e-27 GO:0043170 macromolecule metabolic process
1.68 1.03e-24 GO:0090304 nucleic acid metabolic process
1.68 1.13e-19 GO:0010467 gene expression
1.70 3.51e-19 GO:0016070 RNA metabolic process
1.55 1.14e-17 GO:0044249 cellular biosynthetic process
1.52 1.04e-16 GO:0009058 biosynthetic process
1.41 1.22e-15 GO:0071840 cellular component organization or biogenesis
1.47 7.00e-15 GO:0071841 cellular component organization or biogenesis at cellular level
2.08 1.13e-14 GO:0006396 RNA processing
1.73 1.75e-13 GO:0044085 cellular component biogenesis
1.37 4.32e-12 GO:0016043 cellular component organization
1.45 5.56e-12 GO:0044267 cellular protein metabolic process
1.54 6.60e-12 GO:0044281 small molecule metabolic process
1.41 1.32e-10 GO:0071842 cellular component organization at cellular level
1.54 1.98e-10 GO:0034645 cellular macromolecule biosynthetic process
1.52 4.87e-10 GO:0009059 macromolecule biosynthetic process
1.98 1.33e-09 GO:0016071 mRNA metabolic process
1.61 1.23e-08 GO:0044248 cellular catabolic process
1.53 1.71e-08 GO:0009056 catabolic process
2.58 2.25e-08 GO:0022613 ribonucleoprotein complex biogenesis
3.01 3.28e-08 GO:0042254 ribosome biogenesis
2.49 7.10e-08 GO:0071843 cellular component biogenesis at cellular level
1.48 8.33e-08 GO:0006996 organelle organization
1.40 1.21e-07 GO:0048523 negative regulation of cellular process
1.33 1.21e-07 GO:0019538 protein metabolic process
1.60 2.79e-07 GO:0022607 cellular component assembly
2.22 5.40e-07 GO:0034660 ncRNA metabolic process
2.05 6.06e-07 GO:0044419 interspecies interaction between organisms
2.47 8.07e-07 GO:0034470 ncRNA processing
1.68 1.04e-06 GO:0046907 intracellular transport
2.12 1.09e-06 GO:0006412 translation
1.77 1.33e-06 GO:0009057 macromolecule catabolic process
1.35 1.73e-06 GO:0048522 positive regulation of cellular process
1.28 1.74e-06 GO:0051179 localization
1.36 1.95e-06 GO:0048519 negative regulation of biological process
1.15 3.36e-06 GO:0065007 biological regulation
1.63 3.38e-06 GO:0043933 macromolecular complex subunit organization
1.63 3.93e-06 GO:0033554 cellular response to stress
1.81 4.77e-06 GO:0044265 cellular macromolecule catabolic process
1.94 7.52e-06 GO:0006397 mRNA processing
1.55 7.70e-06 GO:0007049 cell cycle
1.65 9.97e-06 GO:0071844 cellular component assembly at cellular level
1.48 1.20e-05 GO:0051641 cellular localization
1.73 1.45e-05 GO:0071822 protein complex subunit organization
1.31 1.79e-05 GO:0048518 positive regulation of biological process
1.15 2.28e-05 GO:0050789 regulation of biological process
1.72 2.59e-05 GO:0006259 DNA metabolic process
1.16 3.05e-05 GO:0050794 regulation of cellular process
1.51 3.22e-05 GO:0051649 establishment of localization in cell
1.73 3.98e-05 GO:0055086 nucleobase, nucleoside and nucleotide metabolic process
1.54 4.13e-05 GO:0009892 negative regulation of metabolic process
1.28 4.23e-05 GO:0006810 transport
1.56 4.95e-05 GO:0010605 negative regulation of macromolecule metabolic process
2.00 6.46e-05 GO:0008380 RNA splicing
1.28 6.53e-05 GO:0051234 establishment of localization
1.65 9.65e-05 GO:0046483 heterocycle metabolic process
1.56 1.19e-04 GO:0008219 cell death
2.50 1.20e-04 GO:0007005 mitochondrion organization
2.57 1.25e-04 GO:0006403 RNA localization
2.89 1.30e-04 GO:0006364 rRNA processing
1.75 1.33e-04 GO:0034621 cellular macromolecular complex subunit organization
2.58 1.61e-04 GO:0050657 nucleic acid transport
2.58 1.61e-04 GO:0050658 RNA transport
2.58 1.61e-04 GO:0051236 establishment of RNA localization
1.55 1.65e-04 GO:0016265 death
2.19 1.82e-04 GO:0000375 RNA splicing, via transesterification reactions
1.43 2.33e-04 GO:0033036 macromolecule localization
1.79 2.64e-04 GO:0072521 purine-containing compound metabolic process
2.41 3.63e-04 GO:0015931 nucleobase, nucleoside, nucleotide and nucleic acid transport
1.52 3.74e-04 GO:0031324 negative regulation of cellular metabolic process
2.73 5.32e-04 GO:0016072 rRNA metabolic process
1.59 5.85e-04 GO:0065003 macromolecular complex assembly
1.82 6.90e-04 GO:0044271 cellular nitrogen compound biosynthetic process
1.43 9.32e-04 GO:0031325 positive regulation of cellular metabolic process
2.16 9.42e-04 GO:0022411 cellular component disassembly
2.16 9.42e-04 GO:0071845 cellular component disassembly at cellular level
1.30 1.12e-03 GO:0042221 response to chemical stimulus
2.04 1.26e-03 GO:0051186 cofactor metabolic process
2.12 1.41e-03 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
2.12 1.41e-03 GO:0000398 nuclear mRNA splicing, via spliceosome
1.45 1.63e-03 GO:0008104 protein localization
1.60 1.88e-03 GO:0051726 regulation of cell cycle
1.87 2.32e-03 GO:0051325 interphase
1.71 2.40e-03 GO:0008283 cell proliferation
1.87 2.67e-03 GO:0051329 interphase of mitotic cell cycle
1.65 3.42e-03 GO:0006753 nucleoside phosphate metabolic process
1.65 3.42e-03 GO:0009117 nucleotide metabolic process
1.81 3.58e-03 GO:0009259 ribonucleotide metabolic process
1.69 3.80e-03 GO:0016044 cellular membrane organization
1.69 4.66e-03 GO:0061024 membrane organization
1.72 4.77e-03 GO:0016032 viral reproduction
4.09 4.78e-03 GO:0043488 regulation of mRNA stability
1.27 4.88e-03 GO:0006950 response to stress
2.75 4.93e-03 GO:0006839 mitochondrial transport
1.39 5.00e-03 GO:0009893 positive regulation of metabolic process
1.48 5.56e-03 GO:0045184 establishment of protein localization
1.49 5.84e-03 GO:0022402 cell cycle process
1.19 7.14e-03 GO:0051716 cellular response to stimulus
1.93 7.25e-03 GO:0032269 negative regulation of cellular protein metabolic process
1.86 7.99e-03 GO:0010608 posttranscriptional regulation of gene expression
3.95 7.99e-03 GO:0043487 regulation of RNA stability
1.44 8.14e-03 GO:0032774 RNA biosynthetic process
1.42 8.24e-03 GO:0042981 regulation of apoptosis
1.47 9.08e-03 GO:0015031 protein transport
1.53 1.00e-02 GO:0022403 cell cycle phase
1.44 1.07e-02 GO:0042127 regulation of cell proliferation
1.92 1.09e-02 GO:0018130 heterocycle biosynthetic process
1.89 1.24e-02 GO:0051248 negative regulation of protein metabolic process
1.41 1.36e-02 GO:0043067 regulation of programmed cell death
1.41 1.42e-02 GO:0010941 regulation of cell death
2.07 1.45e-02 GO:0006732 coenzyme metabolic process
1.62 1.67e-02 GO:0006461 protein complex assembly
1.59 1.68e-02 GO:0044282 small molecule catabolic process
1.77 1.84e-02 GO:0009150 purine ribonucleotide metabolic process
1.74 1.85e-02 GO:0006520 cellular amino acid metabolic process
3.39 1.86e-02 GO:0006413 translational initiation
2.92 1.94e-02 GO:0009119 ribonucleoside metabolic process
1.29 1.95e-02 GO:0043412 macromolecule modification
2.42 2.02e-02 GO:0006414 translational elongation
1.61 2.20e-02 GO:0070271 protein complex biogenesis
1.23 2.32e-02 GO:0048731 system development
1.66 2.40e-02 GO:0044106 cellular amine metabolic process
1.59 2.70e-02 GO:0044283 small molecule biosynthetic process
1.58 2.85e-02 GO:0006974 response to DNA damage stimulus
1.67 2.93e-02 GO:0006163 purine nucleotide metabolic process
1.59 2.95e-02 GO:0009308 amine metabolic process
1.21 3.01e-02 GO:0048856 anatomical structure development
1.55 3.09e-02 GO:0000278 mitotic cell cycle
5.64 4.15e-02 GO:0042451 purine nucleoside biosynthetic process
5.64 4.15e-02 GO:0042455 ribonucleoside biosynthetic process
5.64 4.15e-02 GO:0046129 purine ribonucleoside biosynthetic process
1.47 4.19e-02 GO:0016192 vesicle-mediated transport
2.29 4.30e-02 GO:0032984 macromolecular complex disassembly
2.29 4.30e-02 GO:0034623 cellular macromolecular complex disassembly
1.61 4.31e-02 GO:0044262 cellular carbohydrate metabolic process
3.91 4.91e-02 GO:0009156 ribonucleoside monophosphate biosynthetic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.23 9.17e-49 GO:0044424 intracellular part
1.34 4.89e-47 GO:0005737 cytoplasm
1.21 4.86e-45 GO:0005622 intracellular
1.45 8.90e-40 GO:0044446 intracellular organelle part
1.44 2.86e-39 GO:0044422 organelle part
1.41 5.30e-37 GO:0044444 cytoplasmic part
1.23 6.87e-30 GO:0043229 intracellular organelle
1.23 1.11e-29 GO:0043226 organelle
1.73 2.71e-29 GO:0044428 nuclear part
1.68 7.08e-28 GO:0031974 membrane-enclosed lumen
1.24 1.54e-26 GO:0043231 intracellular membrane-bounded organelle
1.24 1.58e-26 GO:0043227 membrane-bounded organelle
1.70 9.22e-26 GO:0005829 cytosol
1.65 1.94e-25 GO:0043233 organelle lumen
1.66 3.39e-25 GO:0070013 intracellular organelle lumen
1.72 9.19e-24 GO:0031981 nuclear lumen
1.47 8.46e-23 GO:0032991 macromolecular complex
2.23 4.69e-16 GO:0005730 nucleolus
1.44 3.31e-14 GO:0043228 non-membrane-bounded organelle
1.44 3.31e-14 GO:0043232 intracellular non-membrane-bounded organelle
1.94 1.04e-13 GO:0031967 organelle envelope
1.41 1.15e-13 GO:0043234 protein complex
1.26 1.92e-13 GO:0005634 nucleus
1.65 2.24e-13 GO:0005654 nucleoplasm
1.92 2.38e-13 GO:0031975 envelope
2.08 1.13e-12 GO:0030529 ribonucleoprotein complex
1.43 8.41e-10 GO:0031090 organelle membrane
1.51 3.72e-08 GO:0005739 mitochondrion
1.05 2.53e-07 GO:0044464 cell part
1.05 2.65e-07 GO:0005623 cell
1.85 7.96e-07 GO:0005740 mitochondrial envelope
6.11 2.27e-06 GO:0030530 heterogeneous nuclear ribonucleoprotein complex
1.65 5.31e-06 GO:0044429 mitochondrial part
2.13 6.59e-06 GO:0005635 nuclear envelope
1.81 7.35e-06 GO:0031966 mitochondrial membrane
1.90 2.13e-05 GO:0019866 organelle inner membrane
1.37 1.04e-04 GO:0012505 endomembrane system
1.54 3.79e-04 GO:0044451 nucleoplasm part
1.82 7.59e-04 GO:0005743 mitochondrial inner membrane
1.40 1.06e-03 GO:0000267 cell fraction
2.57 1.33e-03 GO:0042470 melanosome
2.57 1.33e-03 GO:0048770 pigment granule
1.66 1.13e-02 GO:0048471 perinuclear region of cytoplasm
1.41 1.20e-02 GO:0005626 insoluble fraction
5.21 1.53e-02 GO:0005852 eukaryotic translation initiation factor 3 complex
1.41 2.31e-02 GO:0005624 membrane fraction
3.72 3.08e-02 GO:0044452 nucleolar part
1.34 3.42e-02 GO:0005783 endoplasmic reticulum
2.35 3.58e-02 GO:0046930 pore complex
5.39 3.74e-02 GO:0005732 small nucleolar ribonucleoprotein complex
3.24 3.91e-02 GO:0042645 mitochondrial nucleoid

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.44 1.24e-61 GO:0005515 protein binding
1.16 9.99e-27 GO:0005488 binding
1.86 2.08e-13 GO:0003723 RNA binding
1.20 5.39e-07 GO:0003824 catalytic activity
1.35 7.87e-07 GO:0000166 nucleotide binding
2.16 3.79e-03 GO:0003714 transcription corepressor activity
1.29 8.25e-03 GO:0016740 transferase activity
1.28 8.95e-03 GO:0032553 ribonucleotide binding
1.28 8.95e-03 GO:0032555 purine ribonucleotide binding
1.28 9.48e-03 GO:0035639 purine ribonucleoside triphosphate binding
1.51 9.99e-03 GO:0005198 structural molecule activity
2.51 1.28e-02 GO:0008135 translation factor activity, nucleic acid binding
1.65 1.31e-02 GO:0003712 transcription cofactor activity
1.27 1.37e-02 GO:0017076 purine nucleotide binding
1.45 1.40e-02 GO:0042802 identical protein binding
1.65 1.44e-02 GO:0000988 protein binding transcription factor activity
1.65 1.44e-02 GO:0000989 transcription factor binding transcription factor activity
3.29 2.86e-02 GO:0004536 deoxyribonuclease activity
1.42 4.01e-02 GO:0019899 enzyme binding