Project
averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for AAUGCCC
Z-value: 0.35
Motif logo
miRNA associated with seed AAUGCCC
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_-_153574480 Show fit | 1.62 |
ENST00000410080.1
|
PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) |
|
| chr3_+_23986748 Show fit | 1.61 |
ENST00000312521.4
|
nuclear receptor subfamily 1, group D, member 2 |
|
| chr21_-_28217721 Show fit | 1.46 |
ENST00000284984.3
|
ADAM metallopeptidase with thrombospondin type 1 motif, 1 |
|
| chr3_-_55523966 Show fit | 1.37 |
ENST00000474267.1
|
wingless-type MMTV integration site family, member 5A |
|
| chr3_-_33481835 Show fit | 1.34 |
ENST00000283629.3
|
upstream binding protein 1 (LBP-1a) |
|
| chr3_+_113775576 Show fit | 1.15 |
ENST00000485050.1
ENST00000281273.4 |
queuine tRNA-ribosyltransferase domain containing 1 |
|
| chr12_-_15942309 Show fit | 1.08 |
ENST00000544064.1
ENST00000543523.1 ENST00000536793.1 |
epidermal growth factor receptor pathway substrate 8 |
|
| chr12_+_72666407 Show fit | 0.99 |
ENST00000261180.4
|
thyrotropin-releasing hormone degrading enzyme |
|
| chr17_-_78009647 Show fit | 0.94 |
ENST00000310924.2
|
TBC1 domain family, member 16 |
|
| chr12_+_66217911 Show fit | 0.91 |
ENST00000403681.2
|
high mobility group AT-hook 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of AAUGCCC
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.6 | GO:2000505 | regulation of energy homeostasis(GO:2000505) regulation of skeletal muscle cell differentiation(GO:2001014) |
| 0.0 | 1.6 | GO:0032465 | regulation of cytokinesis(GO:0032465) |
| 0.1 | 1.5 | GO:0001542 | ovulation from ovarian follicle(GO:0001542) |
| 0.5 | 1.4 | GO:1904933 | cardiac right atrium morphogenesis(GO:0003213) negative regulation of melanin biosynthetic process(GO:0048022) positive regulation of anagen(GO:0051885) mediolateral intercalation(GO:0060031) cervix development(GO:0060067) lateral sprouting involved in mammary gland duct morphogenesis(GO:0060599) planar cell polarity pathway involved in gastrula mediolateral intercalation(GO:0060775) negative regulation of secondary metabolite biosynthetic process(GO:1900377) regulation of cell proliferation in midbrain(GO:1904933) |
| 0.3 | 1.1 | GO:0070358 | actin polymerization-dependent cell motility(GO:0070358) |
| 0.0 | 1.0 | GO:0043171 | peptide catabolic process(GO:0043171) |
| 0.3 | 0.9 | GO:2000685 | mesodermal-endodermal cell signaling(GO:0003131) programmed DNA elimination(GO:0031049) chromosome breakage(GO:0031052) histone H2A-S139 phosphorylation(GO:0035978) positive regulation of cellular response to X-ray(GO:2000685) |
| 0.1 | 0.9 | GO:2000324 | positive regulation of glucocorticoid receptor signaling pathway(GO:2000324) |
| 0.1 | 0.9 | GO:0000290 | deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290) |
| 0.0 | 0.9 | GO:0006337 | nucleosome disassembly(GO:0006337) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.9 | GO:0030669 | clathrin-coated endocytic vesicle membrane(GO:0030669) |
| 0.1 | 1.6 | GO:0071004 | U2-type prespliceosome(GO:0071004) |
| 0.0 | 1.5 | GO:0005604 | basement membrane(GO:0005604) |
| 0.1 | 1.1 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
| 0.1 | 1.1 | GO:0016442 | RISC complex(GO:0016442) RNAi effector complex(GO:0031332) |
| 0.1 | 0.9 | GO:1990635 | proximal dendrite(GO:1990635) |
| 0.1 | 0.9 | GO:0035985 | senescence-associated heterochromatin focus(GO:0035985) |
| 0.1 | 0.8 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.0 | 0.8 | GO:0016580 | Sin3 complex(GO:0016580) |
| 0.1 | 0.7 | GO:0005614 | interstitial matrix(GO:0005614) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.6 | GO:0001206 | transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206) |
| 0.0 | 1.6 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.1 | 1.4 | GO:0048018 | receptor agonist activity(GO:0048018) |
| 0.0 | 1.4 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 1.2 | GO:0048365 | Rac GTPase binding(GO:0048365) |
| 0.0 | 1.0 | GO:0070006 | metalloaminopeptidase activity(GO:0070006) |
| 0.3 | 0.9 | GO:0035501 | MH1 domain binding(GO:0035501) |
| 0.1 | 0.9 | GO:0050072 | m7G(5')pppN diphosphatase activity(GO:0050072) |
| 0.0 | 0.9 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
| 0.0 | 0.9 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.2 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.1 | 1.9 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.0 | 1.7 | PID CDC42 PATHWAY | CDC42 signaling events |
| 0.0 | 1.2 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 1.1 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.0 | 0.8 | PID BMP PATHWAY | BMP receptor signaling |
| 0.0 | 0.7 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.0 | 0.7 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.0 | 0.6 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.0 | 0.6 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.3 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 1.9 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.0 | 1.0 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.0 | 1.0 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.1 | 0.9 | REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |
| 0.0 | 0.8 | REACTOME RNA POL III TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 0.0 | 0.8 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.0 | 0.6 | REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP | Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
| 0.0 | 0.6 | REACTOME ACTIVATION OF RAC | Genes involved in Activation of Rac |
| 0.0 | 0.6 | REACTOME SIGNALLING TO P38 VIA RIT AND RIN | Genes involved in Signalling to p38 via RIT and RIN |