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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for CUACAGU

Z-value: 0.17

Motif logo

miRNA associated with seed CUACAGU

NamemiRBASE accession
MIMAT0000250

Activity profile of CUACAGU motif

Sorted Z-values of CUACAGU motif

Promoter Log-likelihood Transcript Gene Gene Info
chr5_-_136834982 1.54 ENST00000510689.1
ENST00000394945.1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
chr16_+_58497567 1.24 ENST00000258187.5
NDRG family member 4
chr3_-_114790179 0.83 ENST00000462705.1
zinc finger and BTB domain containing 20
chr3_-_123603137 0.78 ENST00000360304.3
ENST00000359169.1
ENST00000346322.5
ENST00000360772.3
myosin light chain kinase
chr3_+_158991025 0.68 ENST00000337808.6
IQCJ-SCHIP1 readthrough
chr3_+_159557637 0.63 ENST00000445224.2
schwannomin interacting protein 1
chr1_-_225840747 0.55 ENST00000366843.2
ENST00000366844.3
enabled homolog (Drosophila)
chr15_+_39873268 0.48 ENST00000397591.2
ENST00000260356.5
thrombospondin 1
chr19_+_10527449 0.45 ENST00000592685.1
ENST00000380702.2
phosphodiesterase 4A, cAMP-specific
chr9_-_14314066 0.39 ENST00000397575.3
nuclear factor I/B
chr2_+_113033164 0.39 ENST00000409871.1
ENST00000343936.4
zinc finger CCCH-type containing 6
chr9_-_101471479 0.38 ENST00000259455.2
gamma-aminobutyric acid (GABA) B receptor, 2
chr11_-_95657231 0.33 ENST00000409459.1
ENST00000352297.7
ENST00000393223.3
ENST00000346299.5
myotubularin related protein 2
chr17_-_78450398 0.33 ENST00000306773.4
neuronal pentraxin I
chr10_-_735553 0.29 ENST00000280886.6
ENST00000423550.1
DIP2 disco-interacting protein 2 homolog C (Drosophila)
chr3_-_124774802 0.29 ENST00000311127.4
heart development protein with EGF-like domains 1
chrX_-_33146477 0.28 ENST00000378677.2
dystrophin
chr2_-_38604398 0.27 ENST00000443098.1
ENST00000449130.1
ENST00000378954.4
ENST00000539122.1
ENST00000419554.2
ENST00000451483.1
ENST00000406122.1
atlastin GTPase 2
chr15_-_77363513 0.25 ENST00000267970.4
tetraspanin 3
chr4_+_113970772 0.25 ENST00000504454.1
ENST00000394537.3
ENST00000357077.4
ENST00000264366.6
ankyrin 2, neuronal
chr3_-_98620500 0.25 ENST00000326840.6
discoidin, CUB and LCCL domain containing 2
chr8_-_67525473 0.23 ENST00000522677.3
v-myb avian myeloblastosis viral oncogene homolog-like 1
chr16_-_10674528 0.22 ENST00000359543.3
epithelial membrane protein 2
chr2_-_11484710 0.22 ENST00000315872.6
Rho-associated, coiled-coil containing protein kinase 2
chr1_+_29563011 0.21 ENST00000345512.3
ENST00000373779.3
ENST00000356870.3
ENST00000323874.8
ENST00000428026.2
ENST00000460170.2
protein tyrosine phosphatase, receptor type, U
chr1_-_175712829 0.20 ENST00000367674.2
tenascin R
chr20_-_48099182 0.19 ENST00000371741.4
potassium voltage-gated channel, Shab-related subfamily, member 1
chr10_-_99393242 0.17 ENST00000370635.3
ENST00000478953.1
ENST00000335628.3
MORN repeat containing 4
chr15_-_37390482 0.15 ENST00000559085.1
ENST00000397624.3
Meis homeobox 2
chr5_+_149109825 0.14 ENST00000360453.4
ENST00000394320.3
ENST00000309241.5
peroxisome proliferator-activated receptor gamma, coactivator 1 beta
chr1_+_87794150 0.14 ENST00000370544.5
LIM domain only 4
chr17_+_64298944 0.13 ENST00000413366.3
protein kinase C, alpha
chr11_+_92085262 0.13 ENST00000298047.6
ENST00000409404.2
ENST00000541502.1
FAT atypical cadherin 3
chr3_-_129407535 0.13 ENST00000432054.2
transmembrane and coiled-coil domain family 1
chrX_+_146993449 0.13 ENST00000218200.8
ENST00000370471.3
ENST00000370477.1
fragile X mental retardation 1
chr10_-_11653753 0.12 ENST00000609104.1
USP6 N-terminal like
chr5_-_132073210 0.12 ENST00000378735.1
ENST00000378746.4
kinesin family member 3A
chr18_+_3451646 0.11 ENST00000345133.5
ENST00000330513.5
ENST00000549546.1
TGFB-induced factor homeobox 1
chr10_-_70287231 0.11 ENST00000609923.1
solute carrier family 25 (mitochondrial carrier; Graves disease autoantigen), member 16
chr5_+_15500280 0.11 ENST00000504595.1
F-box and leucine-rich repeat protein 7
chr5_-_114598548 0.11 ENST00000379615.3
ENST00000419445.1
protein geranylgeranyltransferase type I, beta subunit
chr6_+_37787262 0.10 ENST00000287218.4
zinc finger, AN1-type domain 3
chr1_-_72748417 0.10 ENST00000357731.5
neuronal growth regulator 1
chr7_+_77325738 0.08 ENST00000334955.8
round spermatid basic protein 1-like
chr2_-_166930131 0.08 ENST00000303395.4
ENST00000409050.1
ENST00000423058.2
ENST00000375405.3
sodium channel, voltage-gated, type I, alpha subunit
chr7_-_56119238 0.08 ENST00000275605.3
ENST00000395471.3
phosphoserine phosphatase
chr15_-_79383102 0.08 ENST00000558480.2
ENST00000419573.3
Ras protein-specific guanine nucleotide-releasing factor 1
chr18_+_55018044 0.08 ENST00000324000.3
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
chrX_+_16804544 0.07 ENST00000380122.5
ENST00000398155.4
taxilin gamma
chr8_+_61591337 0.07 ENST00000423902.2
chromodomain helicase DNA binding protein 7
chr5_-_59189545 0.07 ENST00000340635.6
phosphodiesterase 4D, cAMP-specific
chr1_-_85156216 0.06 ENST00000342203.3
ENST00000370612.4
synovial sarcoma, X breakpoint 2 interacting protein
chr5_-_114961858 0.06 ENST00000282382.4
ENST00000456936.3
ENST00000408996.4
TMED7-TICAM2 readthrough
transmembrane emp24 protein transport domain containing 7
toll-like receptor adaptor molecule 2
chr1_-_21671968 0.06 ENST00000415912.2
endothelin converting enzyme 1
chr2_-_69870835 0.06 ENST00000409085.4
ENST00000406297.3
AP2 associated kinase 1
chr4_+_77870856 0.05 ENST00000264893.6
ENST00000502584.1
ENST00000510641.1
septin 11
chr11_+_86748863 0.05 ENST00000340353.7
transmembrane protein 135
chr12_+_26348429 0.05 ENST00000242729.2
sarcospan
chr2_+_27070964 0.05 ENST00000288699.6
dihydropyrimidinase-like 5
chr3_-_160283348 0.05 ENST00000334256.4
karyopherin alpha 4 (importin alpha 3)
chr6_-_8064567 0.04 ENST00000543936.1
ENST00000397457.2
biogenesis of lysosomal organelles complex-1, subunit 5, muted
chr21_-_36260980 0.04 ENST00000344691.4
ENST00000358356.5
runt-related transcription factor 1
chr1_-_155532484 0.04 ENST00000368346.3
ENST00000548830.1
ash1 (absent, small, or homeotic)-like (Drosophila)
chr8_-_105601134 0.04 ENST00000276654.5
ENST00000424843.2
low density lipoprotein receptor-related protein 12
chr10_+_31608054 0.03 ENST00000320985.10
ENST00000361642.5
ENST00000560721.2
ENST00000558440.1
ENST00000424869.1
ENST00000542815.3
zinc finger E-box binding homeobox 1
chr7_-_138666053 0.03 ENST00000440172.1
ENST00000422774.1
KIAA1549
chr4_-_99579733 0.03 ENST00000305798.3
tetraspanin 5
chr11_+_129939779 0.03 ENST00000533195.1
ENST00000533713.1
ENST00000528499.1
ENST00000539648.1
ENST00000263574.5
amyloid beta (A4) precursor-like protein 2
chr9_+_77112244 0.02 ENST00000376896.3
RAR-related orphan receptor B
chr1_+_37940153 0.02 ENST00000373087.6
zinc finger CCCH-type containing 12A
chr18_-_53255766 0.02 ENST00000566286.1
ENST00000564999.1
ENST00000566279.1
ENST00000354452.3
ENST00000356073.4
transcription factor 4
chr20_-_4982132 0.01 ENST00000338244.1
ENST00000424750.2
solute carrier family 23 (ascorbic acid transporter), member 2
chr6_-_16761678 0.01 ENST00000244769.4
ENST00000436367.1
ataxin 1
chr13_-_21476900 0.01 ENST00000400602.2
ENST00000255305.6
exportin 4
chr12_+_123868320 0.01 ENST00000402868.3
ENST00000330479.4
SET domain containing (lysine methyltransferase) 8
chr3_-_116164306 0.01 ENST00000490035.2
limbic system-associated membrane protein
chr12_+_57998595 0.01 ENST00000337737.3
ENST00000548198.1
ENST00000551632.1
deltex homolog 3 (Drosophila)
chr18_+_49866496 0.00 ENST00000442544.2
deleted in colorectal carcinoma
chr5_-_133561752 0.00 ENST00000519718.1
ENST00000481195.1
S-phase kinase-associated protein 1
protein phosphatase 2, catalytic subunit, alpha isozyme

Network of associatons between targets according to the STRING database.

First level regulatory network of CUACAGU

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0002605 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581) negative regulation of dendritic cell antigen processing and presentation(GO:0002605)
0.1 0.8 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.1 1.2 GO:2001135 regulation of endocytic recycling(GO:2001135)
0.1 0.3 GO:2000645 negative regulation of receptor catabolic process(GO:2000645)
0.1 0.2 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.1 0.4 GO:0021730 trigeminal sensory nucleus development(GO:0021730) principal sensory nucleus of trigeminal nerve development(GO:0021740) negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.0 0.2 GO:0010701 positive regulation of norepinephrine secretion(GO:0010701)
0.0 0.1 GO:2000705 histone H3-T6 phosphorylation(GO:0035408) dense core granule biogenesis(GO:0061110) regulation of dense core granule biogenesis(GO:2000705)
0.0 0.3 GO:0090270 fibroblast growth factor production(GO:0090269) regulation of fibroblast growth factor production(GO:0090270)
0.0 0.2 GO:0048690 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.0 0.2 GO:0010825 positive regulation of centrosome duplication(GO:0010825)
0.0 0.2 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0 0.1 GO:0021553 olfactory nerve development(GO:0021553)
0.0 0.3 GO:0060385 axonogenesis involved in innervation(GO:0060385)
0.0 0.1 GO:0051771 negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771)
0.0 0.3 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.0 0.1 GO:2000301 regulation of intracellular transport of viral material(GO:1901252) negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.0 0.2 GO:0070836 caveola assembly(GO:0070836)
0.0 0.1 GO:0071651 positive regulation of chemokine (C-C motif) ligand 5 production(GO:0071651)
0.0 1.5 GO:0010812 negative regulation of cell-substrate adhesion(GO:0010812)
0.0 0.1 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.0 0.1 GO:0042659 regulation of cell fate specification(GO:0042659)
0.0 0.1 GO:0010814 substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959)
0.0 0.5 GO:0043949 regulation of cAMP-mediated signaling(GO:0043949)
0.0 0.1 GO:0072383 plus-end-directed vesicle transport along microtubule(GO:0072383)
0.0 0.6 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.0 0.0 GO:0044828 negative regulation by host of viral genome replication(GO:0044828)
0.0 0.1 GO:0010265 SCF complex assembly(GO:0010265)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.1 0.2 GO:0072534 perineuronal net(GO:0072534)
0.1 1.6 GO:0033268 node of Ranvier(GO:0033268)
0.0 0.1 GO:0019034 viral replication complex(GO:0019034)
0.0 0.5 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.1 GO:0005953 CAAX-protein geranylgeranyltransferase complex(GO:0005953)
0.0 0.4 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 0.3 GO:0016013 syntrophin complex(GO:0016013)
0.0 0.1 GO:0016939 kinesin II complex(GO:0016939)
0.0 0.1 GO:0031302 intrinsic component of endosome membrane(GO:0031302)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0070052 collagen V binding(GO:0070052)
0.2 0.8 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.1 0.4 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.1 1.5 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.1 GO:0035403 histone kinase activity (H3-T6 specific)(GO:0035403)
0.0 0.1 GO:0004662 CAAX-protein geranylgeranyltransferase activity(GO:0004662)
0.0 0.1 GO:0034046 poly(G) binding(GO:0034046)
0.0 0.3 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.0 0.2 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.0 0.1 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.0 0.1 GO:0050682 AF-2 domain binding(GO:0050682)
0.0 0.5 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.6 GO:0050699 WW domain binding(GO:0050699)
0.0 0.3 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.0 0.1 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.5 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.2 ST JAK STAT PATHWAY Jak-STAT Pathway
0.0 0.7 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.0 0.4 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.4 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.0 0.8 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.1 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.6 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor