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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for POU6F1
Z-value: 0.74
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Transcription factors associated with POU6F1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| POU6F1 | hg19_v2_chr12_-_51611477_51611612 | -0.43 | 2.4e-11 | Click! |
Top targets:  
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr13_+_98612446 Show fit | 14.14 |
ENST00000496368.1
ENST00000421861.2 ENST00000357602.3 |
importin 5 |
|
| chrX_-_122756660 Show fit | 10.90 |
ENST00000441692.1
|
THO complex 2 |
|
| chr2_+_242289502 Show fit | 8.73 |
ENST00000451310.1
|
septin 2 |
|
| chr1_-_197115818 Show fit | 8.49 |
ENST00000367409.4
ENST00000294732.7 |
asp (abnormal spindle) homolog, microcephaly associated (Drosophila) |
|
| chr15_-_85259294 Show fit | 8.47 |
ENST00000558217.1
ENST00000558196.1 ENST00000558134.1 |
SEC11 homolog A (S. cerevisiae) |
|
| chr15_-_85259330 Show fit | 7.76 |
ENST00000560266.1
|
SEC11 homolog A (S. cerevisiae) |
|
| chr15_-_85259384 Show fit | 7.70 |
ENST00000455959.3
|
SEC11 homolog A (S. cerevisiae) |
|
| chr6_-_74231444 Show fit | 7.62 |
ENST00000331523.2
ENST00000356303.2 |
eukaryotic translation elongation factor 1 alpha 1 |
|
| chrX_+_119737806 Show fit | 7.53 |
ENST00000371317.5
|
malignant T cell amplified sequence 1 |
|
| chr5_+_115177178 Show fit | 7.47 |
ENST00000316788.7
|
adaptor-related protein complex 3, sigma 1 subunit |
Network of associatons between targets according to the STRING database.
First level regulatory network of POU6F1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 30.1 | GO:0006465 | signal peptide processing(GO:0006465) |
| 0.9 | 14.1 | GO:0006610 | ribosomal protein import into nucleus(GO:0006610) |
| 0.5 | 13.3 | GO:0072662 | protein targeting to peroxisome(GO:0006625) protein localization to peroxisome(GO:0072662) establishment of protein localization to peroxisome(GO:0072663) |
| 1.1 | 10.9 | GO:0046784 | viral mRNA export from host cell nucleus(GO:0046784) |
| 0.7 | 9.2 | GO:0051382 | kinetochore assembly(GO:0051382) |
| 1.4 | 8.5 | GO:0051661 | maintenance of centrosome location(GO:0051661) |
| 0.1 | 7.9 | GO:0007224 | smoothened signaling pathway(GO:0007224) |
| 0.4 | 7.6 | GO:1904714 | regulation of chaperone-mediated autophagy(GO:1904714) |
| 2.5 | 7.5 | GO:0002188 | translation reinitiation(GO:0002188) |
| 0.5 | 7.5 | GO:0099514 | anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.3 | 30.1 | GO:0005787 | signal peptidase complex(GO:0005787) |
| 0.1 | 14.1 | GO:0005643 | nuclear pore(GO:0005643) |
| 1.6 | 10.9 | GO:0000347 | THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445) |
| 0.6 | 8.7 | GO:0097227 | sperm annulus(GO:0097227) |
| 1.2 | 8.5 | GO:0036449 | microtubule minus-end(GO:0036449) |
| 0.0 | 8.2 | GO:0005813 | centrosome(GO:0005813) |
| 0.0 | 8.0 | GO:0000790 | nuclear chromatin(GO:0000790) |
| 0.8 | 7.6 | GO:0005853 | eukaryotic translation elongation factor 1 complex(GO:0005853) |
| 0.7 | 7.5 | GO:0030123 | AP-3 adaptor complex(GO:0030123) |
| 0.1 | 7.5 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 30.1 | GO:0008236 | serine-type peptidase activity(GO:0008236) |
| 0.6 | 14.1 | GO:0005095 | GTPase inhibitor activity(GO:0005095) |
| 0.3 | 13.3 | GO:0031593 | polyubiquitin binding(GO:0031593) |
| 0.1 | 9.6 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.0 | 9.4 | GO:0003729 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 0.0 | 9.1 | GO:0005516 | calmodulin binding(GO:0005516) |
| 0.0 | 8.7 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.3 | 7.6 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.1 | 7.5 | GO:0008565 | protein transporter activity(GO:0008565) |
| 0.4 | 6.0 | GO:0008179 | adenylate cyclase binding(GO:0008179) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.0 | PID CDC42 PATHWAY | CDC42 signaling events |
| 0.1 | 6.8 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.1 | 6.6 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.1 | 2.8 | PID IL5 PATHWAY | IL5-mediated signaling events |
| 0.0 | 2.3 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 1.4 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.0 | 1.2 | PID IL1 PATHWAY | IL1-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 30.1 | REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
| 0.1 | 14.1 | REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION | Genes involved in Influenza Viral RNA Transcription and Replication |
| 1.3 | 7.6 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.1 | 7.5 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.0 | 5.3 | REACTOME DNA REPAIR | Genes involved in DNA Repair |
| 0.0 | 4.6 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.0 | 3.6 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.1 | 2.8 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.1 | 2.5 | REACTOME EICOSANOID LIGAND BINDING RECEPTORS | Genes involved in Eicosanoid ligand-binding receptors |
| 0.1 | 2.4 | REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |