ISMARA results: UBP1

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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for UBP1

Z-value: 0.57

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Transcription factors associated with UBP1

Gene Symbol	Gene ID	Gene Info
UBP1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000153560.7	upstream binding protein 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
UBP1	hg19_v2_chr3_-_33481835_33481905	0.02	8.0e-01	Click!

Activity profile of UBP1 motif

Sorted Z-values of UBP1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr17_-_5138099 Show fit	10.69	ENST00000571800.1 ENST00000574081.1 ENST00000399600.4 ENST00000574297.1	SCIMP Ensembl NCBI GeneCards UniProt NextProt Show fit	SLP adaptor and CSK interacting membrane protein
chr7_+_142498725 Show fit	9.70	ENST00000466254.1	TRBC2 Ensembl NCBI GeneCards UniProt NextProt Show fit	T cell receptor beta constant 2
chr22_+_22707260 Show fit	7.12	ENST00000390293.1	IGLV5-48 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin lambda variable 5-48 (non-functional)
chr6_+_32709119 Show fit	6.00	ENST00000374940.3	HLA-DQA2 Ensembl NCBI GeneCards UniProt NextProt Show fit	major histocompatibility complex, class II, DQ alpha 2
chr2_-_89442621 Show fit	5.11	ENST00000492167.1	IGKV3-20 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin kappa variable 3-20
chr1_-_150208320 Show fit	4.16	ENST00000534220.1	ANP32E Ensembl NCBI GeneCards UniProt NextProt Show fit	acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr6_+_31555045 Show fit	3.59	ENST00000396101.3 ENST00000490742.1	LST1 Ensembl NCBI GeneCards UniProt NextProt Show fit	leukocyte specific transcript 1
chr22_+_22676808 Show fit	3.45	ENST00000390290.2	IGLV1-51 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin lambda variable 1-51
chr2_+_113033164 Show fit	3.07	ENST00000409871.1 ENST00000343936.4	ZC3H6 Ensembl NCBI GeneCards UniProt NextProt Show fit	zinc finger CCCH-type containing 6
chr19_-_51875523 Show fit	2.73	ENST00000593572.1 ENST00000595157.1	NKG7 Ensembl NCBI GeneCards UniProt NextProt Show fit	natural killer cell group 7 sequence

Showing 1 to 10 of 88 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of UBP1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	10.7	GO:0007127	meiosis I(GO:0007127)
0.1	9.7	GO:0006910	phagocytosis, recognition(GO:0006910)
0.1	8.4	GO:0002377	immunoglobulin production(GO:0002377)
0.1	6.0	GO:0031295	T cell costimulation(GO:0031295)
0.1	5.6	GO:0043486	histone exchange(GO:0043486)
0.0	5.2	GO:0035335	peptidyl-tyrosine dephosphorylation(GO:0035335)
0.2	5.1	GO:0003094	glomerular filtration(GO:0003094)
0.1	3.6	GO:0060216	definitive hemopoiesis(GO:0060216)
0.0	3.6	GO:0032945	negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of lymphocyte proliferation(GO:0050672)
1.2	3.5	GO:0002370	natural killer cell cytokine production(GO:0002370) regulation of natural killer cell cytokine production(GO:0002727)

Showing 1 to 10 of 43 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.1	10.7	GO:0097197	tetraspanin-enriched microdomain(GO:0097197)
0.2	9.7	GO:0042571	immunoglobulin complex, circulating(GO:0042571)
0.3	6.0	GO:0042613	MHC class II protein complex(GO:0042613)
0.3	5.6	GO:0000812	Swr1 complex(GO:0000812)
0.0	5.3	GO:0009898	cytoplasmic side of plasma membrane(GO:0009898)
1.7	5.1	GO:0071748	IgA immunoglobulin complex(GO:0071745) IgA immunoglobulin complex, circulating(GO:0071746) monomeric IgA immunoglobulin complex(GO:0071748) polymeric IgA immunoglobulin complex(GO:0071749) secretory IgA immunoglobulin complex(GO:0071751)
0.0	4.8	GO:0005578	proteinaceous extracellular matrix(GO:0005578)
0.2	3.6	GO:0043205	microfibril(GO:0001527) fibril(GO:0043205)
0.1	2.8	GO:0008074	guanylate cyclase complex, soluble(GO:0008074)
0.2	2.0	GO:0032039	integrator complex(GO:0032039)

Showing 1 to 10 of 19 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	10.0	GO:0003823	antigen binding(GO:0003823)
0.2	9.7	GO:0034987	immunoglobulin receptor binding(GO:0034987)
0.4	6.0	GO:0032395	MHC class II receptor activity(GO:0032395)
0.1	5.6	GO:0019212	phosphatase inhibitor activity(GO:0019212)
0.0	5.2	GO:0004725	protein tyrosine phosphatase activity(GO:0004725)
0.0	3.6	GO:0005201	extracellular matrix structural constituent(GO:0005201)
0.1	2.8	GO:0004383	guanylate cyclase activity(GO:0004383)
0.1	2.1	GO:0042609	CD4 receptor binding(GO:0042609)
0.0	1.7	GO:0008307	structural constituent of muscle(GO:0008307)
0.0	1.7	GO:0005178	integrin binding(GO:0005178)

Showing 1 to 10 of 26 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	5.3	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.0	3.6	PID NOTCH PATHWAY	Notch signaling pathway
0.0	1.5	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.0	1.2	PID RAS PATHWAY	Regulation of Ras family activation
0.0	1.2	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.0	1.0	ST G ALPHA I PATHWAY	G alpha i Pathway
0.0	0.5	PID ENDOTHELIN PATHWAY	Endothelins
0.0	0.4	ST ADRENERGIC	Adrenergic Pathway
0.0	0.3	PID S1P META PATHWAY	Sphingosine 1-phosphate (S1P) pathway

Showing 1 to 9 of 9 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	6.0	REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE	Genes involved in Translocation of ZAP-70 to Immunological synapse
0.1	4.9	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1	2.8	REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE	Genes involved in Nitric oxide stimulates guanylate cyclase
0.0	2.4	REACTOME TOLL RECEPTOR CASCADES	Genes involved in Toll Receptor Cascades
0.0	1.7	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.0	1.2	REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS	Genes involved in Class B/2 (Secretin family receptors)
0.0	1.0	REACTOME SIGNALING BY FGFR1 FUSION MUTANTS	Genes involved in Signaling by FGFR1 fusion mutants
0.0	0.9	REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6	Genes involved in CDK-mediated phosphorylation and removal of Cdc6
0.0	0.7	REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS	Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0	0.5	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)

Showing 1 to 10 of 12 entries

Results for UBP1

Z-value: 0.57

Motif logo

Transcription factors associated with UBP1

Activity-expression correlation:

Activity profile of UBP1 motif

Sorted Z-values of UBP1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of UBP1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: